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Development of a taxis model of cells: application for medicine and evolutionary biology

Research Project

Project/Area Number 17KK0080
Research Category

Fund for the Promotion of Joint International Research (Fostering Joint International Research)

Allocation TypeMulti-year Fund
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionTohoku University

Principal Investigator

Ishikawa Takuji  東北大学, 医工学研究科, 教授 (20313728)

Project Period (FY) 2018 – 2021
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
Keywords微生物 / バイオメカニクス / 数理モデル / シミュレーション / バイオテクノロジー / モデル化
Outline of Final Research Achievements

The research methodology of the parent project includes the step of "innovating theoretical and analytical methods" for microbial biomechanics. In this study, therefore, the mathematical model of phototaxis of microalgae (Gonium) was developed by combining the experimental and mathematical results of the Goldstein Laboratory at the University of Cambridge with the applicant's simulation technology. We have also conducted swimming and feeding analyses of groups of collar flagellates, the origin of multicellular animals, and has expanded microbial biomechanics into evolutionary biology. Besides, we collaborated with Professors Pedley and Lauga of the same department to analyze the stability of microbial swimming and mathematical modeling of microbial suspensions. These results were published in a total of six refereed journal papers, including two in J Fluid Mech, one in Phys Rev E, and one in J Comp Phys.

Academic Significance and Societal Importance of the Research Achievements

微細藻ゴニウムの走光性を数理モデル化した成果は、光環境下の微細藻集団の振る舞いを予測する際の核となる技術である。将来的に有害赤潮藻の行動予測などにもつながる重要な知見である。2体干渉の数値解析で用いた繊毛遊泳モデルは、細胞表面の速度の付着条件と繊毛打による推力を表す新しいものであり、流体力学的に有用な成果である。微生物懸濁液のレオロジー特性を解明した成果は、マクロな連続体スケールの数理モデル化に貢献する成果である。ケンブリッジ大学のGoldstein教授、Pedley教授、Lauga教授と国際共同研究を推進して共著論文を執筆できたことは、日本の微生物バイオメカニクスの国際化に役立つ成果である。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (17 results)

All 2022 2021 2020 2019 Other

All Int'l Joint Research (1 results) Journal Article (6 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 6 results,  Open Access: 3 results) Presentation (8 results) (of which Int'l Joint Research: 7 results,  Invited: 4 results) Remarks (2 results)

  • [Int'l Joint Research] ケンブリッジ大学(英国)2019

    • Related Report
      2021 Annual Research Report
  • [Journal Article] Pairwise scattering and bound states of spherical microorganisms2022

    • Author(s)
      Darveniza C.、Ishikawa T.、Pedley T. J.、Brumley D. R.
    • Journal Title

      Physical Review Fluids

      Volume: 7 Issue: 1 Pages: 013104-013104

    • DOI

      10.1103/physrevfluids.7.013104

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Lubrication theory and boundary element hybrid method for calculating hydrodynamic forces between particles in near contact2022

    • Author(s)
      Ishikawa Takuji
    • Journal Title

      Journal of Computational Physics

      Volume: 452 Pages: 110913-110913

    • DOI

      10.1016/j.jcp.2021.110913

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Zigzag instability of biased pusher swimmers2021

    • Author(s)
      Lauga Eric、Nghi Dang Thanh、Ishikawa Takuji
    • Journal Title

      Europhysics Letters

      Volume: 133 Issue: 4 Pages: 44002-44002

    • DOI

      10.1209/0295-5075/133/44002

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Rheology of a concentrated suspension of spherical squirmers: monolayer in simple shear flow2021

    • Author(s)
      Ishikawa T.、Brumley D.R.、Pedley T.J.
    • Journal Title

      Journal of Fluid Mechanics

      Volume: 914

    • DOI

      10.1017/jfm.2020.885

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Stability of dancing Volvox2020

    • Author(s)
      Ishikawa Takuji、Pedley T. J.、Drescher Knut、Goldstein Raymond E.
    • Journal Title

      Journal of Fluid Mechanics

      Volume: 903

    • DOI

      10.1017/jfm.2020.613

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Motility and Phototaxis of Gonium, the Simplest Differentiated Colonial Alga2020

    • Author(s)
      Helene de Maleprade, Frederic Moisy, Takuji Ishikawa, Raymond E. Goldstein
    • Journal Title

      Physical Review E

      Volume: 101 Pages: 22416-22416

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Presentation] Hydrodynamics of ciliary swimming2021

    • Author(s)
      Takuji Ishikawa
    • Organizer
      Biofluid Symposium
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] RHEOLOGY OF A CONCENTRATED MONOLAYER OF SPHERICAL SQUIRMERS2021

    • Author(s)
      T. J. Pedley, Takuji Ishikawa, D. R. Brumley
    • Organizer
      ICTAM 2020+1 conference
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Dynamic structures in concentrated suspensions of spherical squirmers2021

    • Author(s)
      D. R. Brumley, T. Ishikawa, T. J. Pedley
    • Organizer
      APS March meeting, J05.00010
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Biomechanics can provide a new perspective on microbiology2020

    • Author(s)
      Takuji Ishikawa
    • Organizer
      Webinar in Sharif University of Technology
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 遊泳微生物の動的機能形態学2020

    • Author(s)
      石川拓司
    • Organizer
      幾何学・連続体力学・情報科学の交差領域の探索
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] Functions and Efficiency of Ciliary Swimming2020

    • Author(s)
      Takuji Ishikawa
    • Organizer
      21st RIES-Hokudai International Symposium
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] How do colonial micro-algae swim towards light?2019

    • Author(s)
      Helene De Maleprade, Frederic Moisy, Takuji Ishikawa, Raymond E. Goldstein
    • Organizer
      72nd Annual Meeting of the APS Division of Fluid Dynamics
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Towards the rheology of a concentrated array of spherical squirmers2019

    • Author(s)
      Tim Pedley, Takuji Ishikawa, Douglas Brumley
    • Organizer
      72nd Annual Meeting of the APS Division of Fluid Dynamics
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Remarks] Biological Flow Studies Laboratory

    • URL

      http://www.bfsl.mech.tohoku.ac.jp/index_jp.html

    • Related Report
      2021 Annual Research Report
  • [Remarks] Biological Flow Studies Laboratory

    • URL

      http://www.bfsl.mech.tohoku.ac.jp/

    • Related Report
      2020 Research-status Report 2019 Research-status Report

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Published: 2018-01-25   Modified: 2023-12-25  

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