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Development and scientific creation of structured gene carriers based on controlled higher-order structures of pDNA

Research Project

Project/Area Number 17KK0102
Research Category

Fund for the Promotion of Joint International Research (Fostering Joint International Research)

Allocation TypeMulti-year Fund
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionNational Institutes for Quantum Science and Technology (2018-2023)
The University of Tokyo (2017)

Principal Investigator

Osada Kensuke  国立研究開発法人量子科学技術研究開発機構, 量子医科学研究所 分子イメージング診断治療研究部, グループリーダー (10396947)

Project Period (FY) 2018 – 2023
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
Keywords薬物送達システム / 非ウイルス性遺伝子デリバリーシステム / ポリイオンコンプレックス / DNA凝縮 / 核酸医薬 / 高分子ミセル / 核酸治療 / 非ウイルス性遺伝子ベクター / 高分子集合体
Outline of Final Research Achievements

This study aims to develop the basic research on the control of higher-order structure of complexes consisting of DNA and positively charged polymers and their medical application as gene vectors toward clinical application, deepening the basic science of higher-order structure formation, and further development of a new nucleic acid therapy system, through international joint research. The study has led to international joint research on preclinical gene therapy for cardiovascular diseases, development of nucleic acid therapy system for cancer, nano MRI contrast agents to diagnose diseases, and nano quantum sensor systems to measure in vivo local environment.

Academic Significance and Societal Importance of the Research Achievements

生体の恒常性は遺伝子発現の精密な調節によって保たれており、恒常性の乱れが疾患に関与している。核酸治療は、遺伝子発現を制御することで疾患治療を試みるもので、難治性疾患に対する革新的治療法として期待が寄せられている。この実現には、確実な核酸デリバリーシステムが開発されること、そして研究段階から前臨床開発、臨床応用に至るまでの医薬品開発プロセスを迅速に進めるためのトランスレーション研究と体制の整備が必要である。これら各問題を国際共同研究によって突破しようとする本研究の成果は、核酸治療の開発プロセスをより確実なものとし、社会実装に向けた研究開発を加速するという意義がある。

Report

(7 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (100 results)

All 2024 2023 2022 2021 2020 2019 2018 Other

All Int'l Joint Research (7 results) Journal Article (19 results) (of which Int'l Joint Research: 12 results,  Peer Reviewed: 19 results,  Open Access: 9 results) Presentation (63 results) (of which Int'l Joint Research: 23 results,  Invited: 41 results) Book (6 results) Remarks (1 results) Patent(Industrial Property Rights) (4 results) (of which Overseas: 1 results)

  • [Int'l Joint Research] ライデン大学(オランダ)2024

    • Year and Date
      2024-02-19
    • Related Report
      2023 Annual Research Report
  • [Int'l Joint Research] Dalian University of Technology(中国)2019

    • Year and Date
      2019-12-06
    • Related Report
      2023 Annual Research Report
  • [Int'l Joint Research] ミュンヘン大学(ドイツ)2019

    • Year and Date
      2019-08-23
    • Related Report
      2023 Annual Research Report
  • [Int'l Joint Research] Kent State University, Ohio(米国)2019

    • Year and Date
      2019-07-10
    • Related Report
      2023 Annual Research Report
  • [Int'l Joint Research] VISTECH(タイ)2019

    • Year and Date
      2019-04-03
    • Related Report
      2023 Annual Research Report
  • [Int'l Joint Research] マインツ大学(ドイツ)2019

    • Related Report
      2023 Annual Research Report
  • [Int'l Joint Research] ドレスデン工科大学(ドイツ)2018

    • Related Report
      2023 Annual Research Report
  • [Journal Article] Block copolymer-stabilized MOF hybrids loading Pd nanoparticles enable tumor remission through near-infrared photothermal therapy2024

    • Author(s)
      Shang-Wei Li, Ming-Feng Hsieh, Taehun Hong, Pengwen Chen, Kensuke Osada, Xueying Liu, Ichio Aoki, Jiashing Yu, Kevin C.-W. Wu, Horacio Cabral
    • Journal Title

      Advanced NanoBiomed Research

      Volume: - Issue: 1

    • DOI

      10.1002/anbr.202470011

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Quantification of poly(ethylene glycol) crowding on nanodiamonds toward quantum biosensor for improved prevention effects on protein adsorption and lung accumulation2024

    • Author(s)
      K. Rikiyama, N. Maehara, H. Abe, Y. Nishimura, H. Yukawa, K. Kaminaga, R. Igarashi, K. Osada
    • Journal Title

      Langmuir

      Volume: - Issue: 18 Pages: 9471-9480

    • DOI

      10.1021/acs.langmuir.3c03988

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Self-Folding Macromolecular Drug Carrier for Cancer Imaging and Therapy2023

    • Author(s)
      S. Gao, Y. Miura, A. Sumiyoshi, S. Ohno, K. Ogata, T. Nomoto, M. Matsui, Y. Honda, M. Suzuki, M. Iiyama, K. Osada, I. Aoki, N. Nishiyama
    • Journal Title

      Advanced Science

      Volume: 11 Issue: 7 Pages: 2304171-2304171

    • DOI

      10.1002/advs.202304171

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Size-tunable PEG-grafted copolymers as a polymeric nanoruler for passive targeting muscle tissues.2022

    • Author(s)
      M. Naito, Y. Watanuki, K. Toh, J. Yum, B. S. Kim, K. Taniwaki, S. Ogura, H. Ishida, M. Cho, H. Chaya, K. Miyajima, K. Osada, K. Minegishi, Y. Aoki, Y. Yamasaki, K. Miyata,
    • Journal Title

      Journal of Controlled Release

      Volume: 347 Pages: 607-614

    • DOI

      10.1016/j.jconrel.2022.05.030

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Delivery of aPD-L1 antibody to i.p. tumors via direct penetration by i.p. route: beyond EPR effect.2022

    • Author(s)
      M. Yamamoto, T. Kurino, R. Matsuda, H. S. Jones, Y. Nakamura, T. Kanamori, A. B. Tsuji, A. Sugyo, R. Tsuda, Y. Matsumoto, Y. Sakurai, H. Suzuki, M. Sano, K. Osada, T. Uehara, Y. Ishii, H. Akita, Y. Arano, A. Hisaka, H. Hatakeyama,
    • Journal Title

      Journal of Controlled Release

      Volume: 352 Pages: 328-337

    • DOI

      10.1016/j.jconrel.2022.10.032

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Size-controlled bimodal in vivo nanoprobes as near-infrared phosphors and positive contrast agents for magnetic resonance imaging2021

    • Author(s)
      K. Okubo, R. Takeda, S. Murayama, M. Umezawa, M. Kamimura, K. Osada, I. Aoki, K. Soga,
    • Journal Title

      Science and Technology of Advanced Materials

      Volume: 22 Issue: 6 Pages: 160-172

    • DOI

      10.3390/pharmaceutics13060800

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Bridging mRNA and polycation using RNA oligonucleotide derivatives improves the robustness of polyplex micelle for efficient mRNA delivery.2021

    • Author(s)
      N. Yoshinaga, S. Uchida, A. Dirisala, M. Naito, K. Koji, K. Osada, H. Cabral, K. Kataoka,
    • Journal Title

      Advanced Healthcare Materials,

      Volume: - Issue: 9 Pages: 2102016-2102016

    • DOI

      10.1002/adhm.202102016

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] mRNA loading into ATP-responsive polyplex micelles with optimal density of phenylboronate ester crosslinking to balance robustness in the biological milieu and intracellular translational efficiency2021

    • Author(s)
      Yoshinaga Naoto、Uchida Satoshi、Dirisala Anjaneyulu、Naito Mitsuru、Osada Kensuke、Cabral Horacio、Kataoka Kazunori
    • Journal Title

      Journal of Controlled Release

      Volume: 330 Pages: 317-328

    • DOI

      10.1016/j.jconrel.2020.12.033

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Transient stealth coating of liver sinusoidal wall by anchoring two-armed PEG for retargeting nanomedicines2020

    • Author(s)
      Dirisala Anjaneyulu、Uchida Satoshi、Toh Kazuko、Li Junjie、Osawa Shigehito、Tockary Theofilus A.、Liu Xueying、Abbasi Saed、Hayashi Kotaro、Mochida Yuki、Fukushima Shigeto、Kinoh Hiroaki、Osada Kensuke、Kataoka Kazunori
    • Journal Title

      Science Advances

      Volume: 6 Issue: 26

    • DOI

      10.1126/sciadv.abb8133

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Bundling of mRNA strands inside polyion complexes improves mRNA delivery efficiency in vitro and in vivo2020

    • Author(s)
      Koji Kyoko、Yoshinaga Naoto、Mochida Yuki、Hong Taehun、Miyazaki Takuya、Kataoka Kazunori、Osada Kensuke、Cabral Horacio、Uchida Satoshi
    • Journal Title

      Biomaterials

      Volume: 261 Pages: 120332-120332

    • DOI

      10.1016/j.biomaterials.2020.120332

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Structural Polymorphism of Single pDNA Condensates Elicited by Cationic Block Polyelectrolytes2020

    • Author(s)
      Osada Kensuke
    • Journal Title

      Polymers

      Volume: 12 Issue: 7 Pages: 1603-1603

    • DOI

      10.3390/polym12071603

    • NAID

      120006882399

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 膵臓がんの間質を越える一本鎖DNA内包高分子ベクター2020

    • Author(s)
      長田健介
    • Journal Title

      バイオマテリアル

      Volume: 38 Pages: 196-197

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Single-stranded DNA-packaged polyplex micelle as adeno-associated-virus-inspired compact vector to systemically target stroma-rich pancreatic cancer.2019

    • Author(s)
      T. A. Tockary, W. Foo, A. Dirisala, Q. Chen, S. Uchida, S. Osawa, Y. Mochida, X. Liu, H. Kinoh, H. Cabral, K. Osada, K. Kataoka
    • Journal Title

      ACS Nano

      Volume: 13 Issue: 11 Pages: 12732-12742

    • DOI

      10.1021/acsnano.9b04676

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] In vivo rendezvous of small nucleic acid drugs with charge-matched block catiomers to target cancers2019

    • Author(s)
      Watanabe Sumiyo、Hayashi Kotaro、Toh Kazuko、Kim Hyun Jin、Liu Xueying、Chaya Hiroyuki、Fukushima Shigeto、Katsushima Keisuke、Kondo Yutaka、Uchida Satoshi、Ogura Satomi、Nomoto Takahiro、et al.
    • Journal Title

      Nature Communications

      Volume: 10 Issue: 1 Pages: 1894-1894

    • DOI

      10.1038/s41467-019-09856-w

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Bundling mRNA strands to prepare nano-assemblies with enhanced stability towards RNase for in vivo delivery.2019

    • Author(s)
      N. Yoshinaga, E. Cho, K. Koji, Y. Mochida, M. Naito, K. Osada, K. Kataoka, H. Cabral, S. Uchida
    • Journal Title

      Angew. Chem. Int. Ed.

      Volume: 58 Issue: 33 Pages: 11360-11363

    • DOI

      10.1002/anie.201905203

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Precise tuning of disulfide crosslinking in mRNA polyplex micelles for optimizing extracellular and intracellular nuclease tolerability.2019

    • Author(s)
      A. Dirisala, S. Uchida, T. A. Tockary, N. Yoshinaga, J. Li, S. Osawa, L. Gorantla, S. Fukushima, K. Osada, K. Kataoka
    • Journal Title

      J. Drug Target.

      Volume: 印刷中 Issue: 5-6 Pages: 670-680

    • DOI

      10.1080/1061186x.2018.1550646

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Induced packaging of mRNA into polyplex micelles by regulated hybridization with a small number of cholesteryl RNA oligonucleotides directed enhanced in vivo transfection.2019

    • Author(s)
      N. Yoshinaga, S. Uchida, M. Naito, K. Osada, H. Cabral, K. Kataoka
    • Journal Title

      Biomaterials

      Volume: 197 Pages: 255-267

    • DOI

      10.1016/j.biomaterials.2019.01.023

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Versatile DNA folding structures organized by cationic block copolymers2019

    • Author(s)
      Osada Kensuke
    • Journal Title

      Polymer Journal

      Volume: 51 Issue: 4 Pages: 381-387

    • DOI

      10.1038/s41428-018-0157-0

    • NAID

      40021935767

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Block Copolymer Micelles in Nanomedicine Applications2018

    • Author(s)
      Cabral Horacio、Miyata Kanjiro、Osada Kensuke、Kataoka Kazunori
    • Journal Title

      Chemical Reviews

      Volume: 118 Issue: 14 Pages: 6844-6892

    • DOI

      10.1021/acs.chemrev.8b00199

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Liver sinusoidal wall coating polymer to promote the efficacy of gene therapy drugs, The 40th International Conference of Photopolymer Science and Technology2023

    • Author(s)
      K. Osada
    • Organizer
      The 40th International Conference of Photopolymer Science and Technology
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Polymeric Architectures to Perform Virus Functions and its Challenge to Pancreatic Cancer2023

    • Author(s)
      K. Osada
    • Organizer
      International Conference on Precision Nanomedicine in Theranostics & The 2023 Annual Meeting of Taiwan Nanomedicine Society
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ナノダイヤモンドの定量的PEG化2023

    • Author(s)
      長田健介
    • Organizer
      量子生命科学先端フォーラム2023夏の研究会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 生体量子センシングのためのナノダイヤモンドの定量的PEG化2023

    • Author(s)
      長田健介, 力山和晃
    • Organizer
      第72回高分子討論会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 日本学術振興会特別研究員応募書類作成で気をつけたいこと2023

    • Author(s)
      長田健介
    • Organizer
      NITech PGCプログラム日本学術振興会特別研究員申請支援セミナー
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 高分子で挑む膵臓がんの遺伝子/核酸治療2023

    • Author(s)
      長田健介
    • Organizer
      増殖制御遺伝子TOB研究会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Quantification of PEG crowding grafted onto nanodiamonds2023

    • Author(s)
      K. Osada
    • Organizer
      The 11th Conference on Exploring Next-Generation Materials Science and Nanoscience (11thCENG-MSN) and Workshop on Soft and Nano Materials Orchestrated with Wisdom from Japan 2024 (SNOWJ2024)
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Nano-Ruler MRI contrast agent to detect inflammatory vasculature2023

    • Author(s)
      K. Osada, N. Maehara, A. Sumiyoshi, M. Naito, K. Miyata, I. Aoki,
    • Organizer
      The 11th Takeda Science Foundation Symposium on Pharmasciences, Congres Convention Center
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Nano-Ruler MRI contrast agent to detect inflammatory vasculature2023

    • Author(s)
      K. Osada
    • Organizer
      MRI Symposium Osaka
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Transient stealth coating of liver sinusoidal wall by PEG for retargeting nanomedicines2023

    • Author(s)
      K. Osada
    • Organizer
      1st Workshop on Soft and Nano Materials Orchestrated with Wisdom from Japan and Korea 2024
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 生体量子センシングのためのナノダイヤモンドの定量的PEG化2023

    • Author(s)
      長田健介
    • Organizer
      第13回ナノバイオ若手ネットワーキングシンポジウム
    • Related Report
      2023 Annual Research Report
  • [Presentation] Polymers for cancer therapy and diagnosis2023

    • Author(s)
      K. Osada
    • Organizer
      Seminar in Division of BioTherapeutics, Leiden Univeristy
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Artificial viruses to target cancers by polymer nanoassembly technology2023

    • Author(s)
      長田健介
    • Organizer
      OIST Seminar
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 化学で生命に迫る ~高分子化学でがんに挑む2022

    • Author(s)
      長田健介
    • Organizer
      東進ハイスクール未来発見講座
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] ナノダイヤモンドの定量的PEG化の試み2022

    • Author(s)
      長田健介
    • Organizer
      量子計測技術による細胞生物物理学の進展と生命のパラメトリク生理機能の解明への展開
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] がん微小環境を診る高分子造影剤の開発とPDXモデルへの適用2022

    • Author(s)
      長田健介, 力山和晃, 綿貫裕介, 内藤瑞, 宮田完二郎, 住吉晃, 青木伊知男
    • Organizer
      第38回日本DDS学会
    • Related Report
      2022 Research-status Report
  • [Presentation] がん微小環境を診る高分子造影剤の開発とPDXモデルへの適用2022

    • Author(s)
      長田健介
    • Organizer
      第71回高分子討論会
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] 高分子化学を道具にがんに挑戦する試みとナノダイヤモンド量子計測への展開2022

    • Author(s)
      長田健介
    • Organizer
      大阪大学蛋白研セミナー
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] 高分子化学を道具にがんに挑戦する研究2022

    • Author(s)
      長田健介
    • Organizer
      茨城県立水戸第一高等学校大学模擬講義
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] がん微小環境を診る高分子造影剤の開発とPDXモデルへの適用2022

    • Author(s)
      長田健介, 力山和晃, 綿貫裕介, 内藤瑞, 宮田完二郎, 住吉晃, 青木伊知男
    • Organizer
      第44回バイオマテリアル学会大会
    • Related Report
      2022 Research-status Report
  • [Presentation] A safe liver sinusoidal wall coating agent to promote the efficacy of gene therapy drugs2022

    • Author(s)
      長田健介
    • Organizer
      International Symposium on Chemistry 2022 and the 2nd Kyutech-KKU International Symposium
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] A safe liver sinusoidal wall coating agent to promote the efficacy of gene therapy drugs2022

    • Author(s)
      長田健介
    • Organizer
      The 5th International Conference on Nanospace Materials 2022
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Through the stromal barrier to pancreatic cancer cell nests: Single-stranded DNA-packaged polyplex micelle as AAV-inspired compact gene vector2022

    • Author(s)
      長田健介
    • Organizer
      The 5th International Workshop by the 174th Committee on Coexistence of Biology and Nanodevices
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] A safe liver sinusoidal wall coating agent to promote the efficacy of gene therapy drugs2022

    • Author(s)
      長田健介
    • Organizer
      The 4th International Conference on Materials Research and Innovation
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 化学で生命を作る挑戦2022

    • Author(s)
      長田健介
    • Organizer
      MRI Collaborator’s Workshop 2022
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] ナノメディシンの送達効率を高める肝類洞内皮壁高分子コーティング剤2021

    • Author(s)
      長田健介, Anjaneyulu Dirisala, 内田智士, 片岡一則
    • Organizer
      第15回日本分子イメージング学会
    • Related Report
      2021 Research-status Report
  • [Presentation] 膵臓がんの間質を超える一本鎖DNA内包ポリプレックスミセル2021

    • Author(s)
      長田健介, Theofilus A. Tockary, 片岡一則
    • Organizer
      第37回日本DDS学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 高分子で作る人工ウイルスと遺伝子治療への展開2021

    • Author(s)
      長田健介
    • Organizer
      CSJ化学フェスタ
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] DNAをたたむ、遺伝子を発現させる、病気を治す2021

    • Author(s)
      長田健介
    • Organizer
      茨城県立水戸第一高等学校大学模擬講義
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 非ウイルス性遺伝子治療 ~新しい遺伝子ベクターの設計と医療への応用~2021

    • Author(s)
      長田健介
    • Organizer
      BioJapan
    • Related Report
      2021 Research-status Report
  • [Presentation] 核酸デリバリーシステムにおける核酸とポリアミノ酸との相互作用解析2021

    • Author(s)
      長田健介
    • Organizer
      BINDS NMR報告会
    • Related Report
      2021 Research-status Report
  • [Presentation] 生体計測を目指したナノダイヤモンド量子センサーの開発2021

    • Author(s)
      長田健介
    • Organizer
      スイゼンジノリ・サクラン研究会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] ナノダイヤモンドを用いた生体ナノ量子センサーの開発2021

    • Author(s)
      長田健介
    • Organizer
      福岡工業大学総合研究機構エレクトロニクス研究所講演会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] Single-stranded DNA-packaged Polyplex Micelle as AAV-inspired Compact Gene Vector to Systemically Target Stroma-rich Pancreatic Cancer2021

    • Author(s)
      長田健介
    • Organizer
      ICMARI2021
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] DDSの基礎と応用2020

    • Author(s)
      長田健介
    • Organizer
      量子生命科学先端フォーラム2020夏の勉強会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] Strategic design of polyplex micelles toward systemic gene delivery2020

    • Author(s)
      Kensuke Osada
    • Organizer
      Seminar, University of Michigan
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] DNAをたたむ、遺伝子を発現させる、病気を治す2020

    • Author(s)
      長田健介
    • Organizer
      茨城県立水戸第一高等学校大学模擬講義
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 一本鎖DNA内包ポリプレックスミセルによる膵臓がんの間質通過戦略2020

    • Author(s)
      長田健介, Theofilus A. Tockary, 片岡一則
    • Organizer
      第69回高分子学会年次大会
    • Related Report
      2020 Research-status Report
  • [Presentation] Control of versatile higher-ordered structures of pDNA-block copolymer complexes and their application as gene delivery system2019

    • Author(s)
      Kensuke Osada
    • Organizer
      Seminar at VISTEC
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Compartmentalization of single-stranded DNA from pDNA by polyplex micelles2019

    • Author(s)
      Kensuke Osada, Theofilus A. Tockary, Kazunori Kataoka
    • Organizer
      第67回高分子学会年次大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 高分子ミセルによる一本鎖DNAの隔離化2019

    • Author(s)
      長田健介
    • Organizer
      NanoBio第12回若手ネットワーキングシンポジウム
    • Related Report
      2019 Research-status Report
  • [Presentation] Control of versatile higher-ordered structures of pDNA by block copolymers and their application as gene delivery system2019

    • Author(s)
      Kensuke Osada
    • Organizer
      Seminar at Institute of Polymers, Bulgaria Academy of Science, Sofia, Bulgaria,
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Control of versatile higher-ordered structures of pDNA by block copolymers and their application as gene delivery system2019

    • Author(s)
      Kensuke Osada
    • Organizer
      Seminar at Institute of Macromolecular Chemistry, Freiburg University, Germany
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Control of versatile higher-ordered structures of pDNA by block copolymers and their application as gene delivery system2019

    • Author(s)
      Kensuke Osada
    • Organizer
      Workshop on Nano-Bio interfaces
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 一本鎖DNA内包ポリプレックスミセルの遺伝子発現活性2019

    • Author(s)
      長田健介, Theofilus Tockary, 片岡一則
    • Organizer
      第68回高分子学会討論会
    • Related Report
      2019 Research-status Report
  • [Presentation] DNA一本鎖は遺伝子発現するか2019

    • Author(s)
      長田健介
    • Organizer
      第一回量子生命科学会若手の会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 膵臓がんの間質を超える一本鎖DNA内包ポリプレックスミセル2019

    • Author(s)
      長田健介, Theofilus A. Tockary, 片岡一則
    • Organizer
      第41回バイオマテリアル学会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Compartmentalization of single-stranded DNA from pDNA by polyplex micelles2019

    • Author(s)
      Kensuke Osada, Theofilus A. Tockary, Kazunori Kataoka
    • Organizer
      2nd GLowing Polymer Symposium in KANTO (GPS-K 2019)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Control of versatile higher-ordered structures of pDNA by block copolymers and their application as gene delivery system2019

    • Author(s)
      Kensuke Osada
    • Organizer
      Seminar at Ningbo Institute of Material Technology and Engineering, Chinese Academy of Sciences
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Control of versatile higher-ordered structures of pDNA by block copolymers and their application as gene delivery system2019

    • Author(s)
      Kensuke Osada
    • Organizer
      ICMARI 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Control of higher ordered structures of pDNA-block copolymer complexes and their application for systemic gene therapy2019

    • Author(s)
      Kensuke Osada
    • Organizer
      VISTEC special lectures 2019
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Control of versatile higher-ordered structures of pDNA-block copolymer complexes and their application as gene delivery system2019

    • Author(s)
      Kensuke Osada
    • Organizer
      Lecture series by Collaborative Research Center 1066
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Control of versatile higher-ordered structures of pDNA-block copolymer complexes and their application as gene delivery system2019

    • Author(s)
      Kensuke Osada
    • Organizer
      Seminar at Department of Chemistry, University of Strasbourg
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] DNA-高分子複合体が創る多様な高次構造と医療への展開2018

    • Author(s)
      長田健介
    • Organizer
      QST未来ラボセミナー
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] DNA-高分子複合体が創る多様な高次構造と医療への展開2018

    • Author(s)
      長田健介
    • Organizer
      量子生命科学研究会第二回学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] せん断応力に対するポリプレックスミセルの構造安定性2018

    • Author(s)
      長田健介、武田香織、山崎裕一、片岡一則
    • Organizer
      67回高分子学会年次大会
    • Related Report
      2018 Research-status Report
  • [Presentation] ポリプレックスミセル対する血流せん断応力の影響2018

    • Author(s)
      長田健介、武田香織、山崎裕一、片岡一則
    • Organizer
      第 34回 DDS学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 高分子ミセルによる一本鎖DNAの隔離化2018

    • Author(s)
      長田健介, Theofilus Tockary, 片岡一則
    • Organizer
      第67回高分子学会討論会
    • Related Report
      2018 Research-status Report
  • [Presentation] DNAをたたむ、遺伝子を発現させる2018

    • Author(s)
      長田健介
    • Organizer
      茨城県立水戸第一高等学校大学模擬講義
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] ウイルスの構造・機能に学ぶ高分子ミセル型遺伝子キャリアの開発2018

    • Author(s)
      長田健介
    • Organizer
      積水化学フォーラム
    • Related Report
      2018 Research-status Report
  • [Presentation] DNAの折りたたみ制御と膵臓がんの遺伝子治療への展開2018

    • Author(s)
      長田健介
    • Organizer
      第35回医用高分子研究会講座
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Versatile higher ordered structures of pDNA-block copolymer complexes and their application as gene delivery system2018

    • Author(s)
      Kensuke Osada
    • Organizer
      DNA-Mitteldeutschland Winter Meeting 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Versatile higher ordered structures of pDNA-block copolymer complexes and their application as gene delivery system2018

    • Author(s)
      Kensuke Osada
    • Organizer
      1st GLowing Polymer Symposium in KANTO
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Book] Drug Delivery System2022

    • Author(s)
      長田健介
    • Total Pages
      10
    • Publisher
      日本DDS学会
    • Related Report
      2021 Research-status Report
  • [Book] 高分子2021

    • Author(s)
      長田健介
    • Total Pages
      2
    • Publisher
      高分子学会
    • Related Report
      2021 Research-status Report
  • [Book] Drug Delivery System2021

    • Author(s)
      青木伊知男, 長田健介, 住吉晃, Bakalova Rumiana
    • Total Pages
      17
    • Publisher
      日本DDS学会
    • Related Report
      2021 Research-status Report
  • [Book] 核酸科学ハンドブック2020

    • Author(s)
      長田健介
    • Total Pages
      576
    • Publisher
      講談社
    • ISBN
      9784065207864
    • Related Report
      2020 Research-status Report
  • [Book] ドラッグキャリア設計入門2019

    • Author(s)
      片岡 一則、原島 秀吉
    • Total Pages
      240
    • Publisher
      丸善出版
    • ISBN
      9784621303658
    • Related Report
      2018 Research-status Report
  • [Book] Molecular Technology Vol. 2 Life Innovation2018

    • Author(s)
      Molecular technology for control of DNA folding within polyplex micelles by block catiomers toward systemic gene therapy
    • Total Pages
      400
    • Publisher
      Wiley-VCH
    • Related Report
      2018 Research-status Report
  • [Remarks] 遺伝子治療の効率を安全かつ大幅に高める 肝内毛細血管コーティング剤の開発

    • URL

      https://www.qst.go.jp/site/press/41886.html

    • Related Report
      2020 Research-status Report
  • [Patent(Industrial Property Rights)] 単一高分子からなる自己凝集型ミセル2023

    • Inventor(s)
      三浦裕,西山伸宏,ガ オシャン,青木伊知 男,長田健介,住吉晃,
    • Industrial Property Rights Holder
      東京工業大学、量子科学技術研究開発機構
    • Industrial Property Rights Type
      特許
    • Filing Date
      2023
    • Related Report
      2023 Annual Research Report
  • [Patent(Industrial Property Rights)] 修飾済基材,修飾済基材の製造方法,及び,修飾済基材における重なり合い密度の評価方法2023

    • Inventor(s)
      長田健介, 力山和晃
    • Industrial Property Rights Holder
      量子科学技術研究開発機構
    • Industrial Property Rights Type
      特許
    • Filing Date
      2023
    • Related Report
      2023 Annual Research Report
  • [Patent(Industrial Property Rights)] 単一高分子粒子、活性分子複合体、単一高分子粒子の製造方法、腫瘍サイズの計測方法、腫瘍内の微細構造の計測方法、生体組織のイメージング方法、ドラッグデリバリーシステム、造影剤キット2023

    • Inventor(s)
      長田健介, 力山和晃, 住吉晃, 青木伊知男, 内藤瑞, 等
    • Industrial Property Rights Holder
      長田健介, 力山和晃, 住吉晃, 青木伊知男, 内藤瑞, 等
    • Industrial Property Rights Type
      特許
    • Filing Date
      2023
    • Related Report
      2022 Research-status Report
    • Overseas
  • [Patent(Industrial Property Rights)] 単一高分子粒子、活性分子複合体、単一高分子粒子の製造方法、腫瘍サイズの計測方法、腫瘍内の微細構造の計測方法、生体組織のイメージング方法、ドラッグデリバリーシステム、造影剤キット2022

    • Inventor(s)
      長田健介, 力山和晃, 住吉晃, 青木伊知男, 内藤瑞, 等
    • Industrial Property Rights Holder
      長田健介, 力山和晃, 住吉晃, 青木伊知男, 内藤瑞, 等
    • Industrial Property Rights Type
      特許
    • Filing Date
      2022
    • Related Report
      2022 Research-status Report

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Published: 2018-01-25   Modified: 2025-01-30  

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