Research Project
Fund for the Promotion of Joint International Research (Fostering Joint International Research)
This study aims to develop the basic research on the control of higher-order structure of complexes consisting of DNA and positively charged polymers and their medical application as gene vectors toward clinical application, deepening the basic science of higher-order structure formation, and further development of a new nucleic acid therapy system, through international joint research. The study has led to international joint research on preclinical gene therapy for cardiovascular diseases, development of nucleic acid therapy system for cancer, nano MRI contrast agents to diagnose diseases, and nano quantum sensor systems to measure in vivo local environment.
生体の恒常性は遺伝子発現の精密な調節によって保たれており、恒常性の乱れが疾患に関与している。核酸治療は、遺伝子発現を制御することで疾患治療を試みるもので、難治性疾患に対する革新的治療法として期待が寄せられている。この実現には、確実な核酸デリバリーシステムが開発されること、そして研究段階から前臨床開発、臨床応用に至るまでの医薬品開発プロセスを迅速に進めるためのトランスレーション研究と体制の整備が必要である。これら各問題を国際共同研究によって突破しようとする本研究の成果は、核酸治療の開発プロセスをより確実なものとし、社会実装に向けた研究開発を加速するという意義がある。
All 2024 2023 2022 2021 2020 2019 2018 Other
All Int'l Joint Research (7 results) Journal Article (19 results) (of which Int'l Joint Research: 12 results, Peer Reviewed: 19 results, Open Access: 9 results) Presentation (63 results) (of which Int'l Joint Research: 23 results, Invited: 41 results) Book (6 results) Remarks (1 results) Patent(Industrial Property Rights) (4 results) (of which Overseas: 1 results)
Advanced NanoBiomed Research
Volume: - Issue: 1
10.1002/anbr.202470011
Langmuir
Volume: - Issue: 18 Pages: 9471-9480
10.1021/acs.langmuir.3c03988
Advanced Science
Volume: 11 Issue: 7 Pages: 2304171-2304171
10.1002/advs.202304171
Journal of Controlled Release
Volume: 347 Pages: 607-614
10.1016/j.jconrel.2022.05.030
Volume: 352 Pages: 328-337
10.1016/j.jconrel.2022.10.032
Science and Technology of Advanced Materials
Volume: 22 Issue: 6 Pages: 160-172
10.3390/pharmaceutics13060800
Advanced Healthcare Materials,
Volume: - Issue: 9 Pages: 2102016-2102016
10.1002/adhm.202102016
Volume: 330 Pages: 317-328
10.1016/j.jconrel.2020.12.033
Science Advances
Volume: 6 Issue: 26
10.1126/sciadv.abb8133
Biomaterials
Volume: 261 Pages: 120332-120332
10.1016/j.biomaterials.2020.120332
Polymers
Volume: 12 Issue: 7 Pages: 1603-1603
10.3390/polym12071603
120006882399
バイオマテリアル
Volume: 38 Pages: 196-197
ACS Nano
Volume: 13 Issue: 11 Pages: 12732-12742
10.1021/acsnano.9b04676
Nature Communications
Volume: 10 Issue: 1 Pages: 1894-1894
10.1038/s41467-019-09856-w
Angew. Chem. Int. Ed.
Volume: 58 Issue: 33 Pages: 11360-11363
10.1002/anie.201905203
J. Drug Target.
Volume: 印刷中 Issue: 5-6 Pages: 670-680
10.1080/1061186x.2018.1550646
Volume: 197 Pages: 255-267
10.1016/j.biomaterials.2019.01.023
Polymer Journal
Volume: 51 Issue: 4 Pages: 381-387
10.1038/s41428-018-0157-0
40021935767
Chemical Reviews
Volume: 118 Issue: 14 Pages: 6844-6892
10.1021/acs.chemrev.8b00199
https://www.qst.go.jp/site/press/41886.html