Multi-physics and multi-scale simulation of vascular network in biosystem
| Project/Area Number |
17KK0128
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| Research Category |
Fund for the Promotion of Joint International Research (Fostering Joint International Research)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Fluid engineering
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2018 – 2020
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥14,170,000 (Direct Cost: ¥10,900,000、Indirect Cost: ¥3,270,000)
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| Keywords | 血管網リモデリング / 血流シミュレーション / マルチスケール・マルチフィジックス解析 / ゼブラフィッシュ / 血管リモデリング / マルチ・フェデリティ・シミュレーション |
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| Outline of Final Research Achievements |
We developed image processing techniques for reconstructing a complex three-dimensional vascular network structure from a series of confocal microscope images obtained from young zebrafish for blood flow simulation. Based on the obtained structures, we applied three different approaches for blood flow simulation, i.e., dissipative particle dynamics, three-dimensional continuum model and one-dimensional models under the same blood flow condition. In addition, by introducing the idea of parallelizing in time, we propose and validate a new simulation strategy, in which the entire time domain is decomposed into small sub-domains so that expensive DPD simulations can be conducted separately, and these results are integrated through cheap 1D model simulation.
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| Academic Significance and Societal Importance of the Research Achievements |
生体内において血管が形成される過程、血管構造が異常化する過程を理解することは、血管発生学、医学、再生医療の分野において極めて重要な課題である。血管形成においては、血管内壁を構成する血管内皮細胞に対する血流による力学刺激が特に重要な因子であることが指摘されているものの、生体内において上記の血行力学因子を計測することは困難であるため、血管形成の機構については十分に理解が進んでいない。本研究では、ゼブラフィッシュのライブイメージングを通じて、脳内部の複雑３次元血管構造の再構築に成功すると共に、血流シミュレーションによって、血管内部の局所のせん断応力、圧力などの血行力学因子の予測ツールを開発した。
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Report
(4 results)
Research Products
(38 results)
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[Journal Article] Multiscale parareal algorithm for long-time mesoscopic simulations of microvascular blood flow in Zebrafish2021
Author(s)
Blumers, A., Yin, M., Nakajima, H., Hasegawa, Y., Li, Z., Karniadakis, G.E.
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Journal Title
arXiv
Volume: 2101.08414
Pages: 1-23
Related Report
Open Access / Int'l Joint Research
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[Presentation] Comparison of Multi-scale Models for Blood Flow in Zebrafish Brain2019
Author(s)
Yin, M., Zheng, X., Blumers, A., Nakakura, M., Nakajima, H., Hasegawa, Y., Karniadakis, G.
Organizer
72nd Annual Meeting of the APS Division of Fluid Dynamics
Related Report
Int'l Joint Research
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[Presentation] Numerical study on Hemodynamics of brain vasculature in eartly ebrafish life2019
Author(s)
Yin, M., Zheng, X., Blumers, A., Nakakura, M., Nakajima, H., Hasegawa, Y., Karniadakis, G.
Organizer
Biomedical Engineering Society 2019 (BMES2019)
Related Report
Int'l Joint Research
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[Presentation] Adjoint-based optimization of heat transfer surface in latent heat thermal storage system2019
Author(s)
Kametani, Y., Yuasa, T., Matsumoto, K., Shoda, T., Ishii, M., and Hasegawa, Y.
Organizer
The 2nd Pacific Rim Thermal Engineering Conference (PRTEC2019)
Related Report
Int'l Joint Research
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