| Outline of Final Research Achievements |
We developed image processing techniques for reconstructing a complex three-dimensional vascular network structure from a series of confocal microscope images obtained from young zebrafish for blood flow simulation. Based on the obtained structures, we applied three different approaches for blood flow simulation, i.e., dissipative particle dynamics, three-dimensional continuum model and one-dimensional models under the same blood flow condition. In addition, by introducing the idea of parallelizing in time, we propose and validate a new simulation strategy, in which the entire time domain is decomposed into small sub-domains so that expensive DPD simulations can be conducted separately, and these results are integrated through cheap 1D model simulation.
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