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Clarifying of relationship between hand movement and phase of beta oscillation by optogenetic stimulation in awake monkey

Research Project

Project/Area Number 17KK0140
Research Category

Fund for the Promotion of Joint International Research (Fostering Joint International Research)

Allocation TypeMulti-year Fund
Research Field Brain biometrics
Research InstitutionTohoku University

Principal Investigator

Watanabe Hidenori  東北大学, 医学系研究科, 助教 (00407686)

Project Period (FY) 2018 – 2021
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Keywords運動制御 / オプトジェネティクス(光遺伝学) / 脳波 / ベータ波 / 一次運動野 / 位相ロック / 感覚応答 / サル / 認知行動 / 上肢到達運動 / 上肢運動 / 神経科学 / 光操作
Outline of Final Research Achievements

It has been reported that phase of the β oscillations in the motor cortex are locked by visual stimuli instructed task condition in resting periods during the behavioral tasks. To clarify the relationship between motor control and the phase-locking (PL) of beta oscillation, neural activities in the motor cortex were modulated at the timing of visual stimuli by optogenetic stimuli in awake monkey. That work collaborated with Dr. Hatsopoulos at the University of Chicago, who focused on beta oscillations in motor control. Optical stimulation induced evoked potentials in a wide area of the primary motor cortex during a reaching task. Across most recording sites, the PLs with the stimulation under motor threshold enhanced significantly in according to ones in the task trials without the stimulation. These results suggest the involvement of intrinsic neuronal activity in the primary motor cortex in the generation of PL in response to sensory stimulation.

Academic Significance and Societal Importance of the Research Achievements

脳波に代表される神経活動の振動現象の機能解明は睡眠・記憶を介した免疫系強化や注意欠陥障害児の治療など社会的な期待を受けてる.また神経刺激による行動制御は社会性,パーキンソン病,意識覚醒等に深く関与する事実から神経科学における重要な基盤研究の1つである.行動に直接関係する大脳皮質運動野において周期的神経活動の操作可能性を示した本研究の社会・神経科学的意義は大である.

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (14 results)

All 2022 2021 2020 2019 2018 Other

All Int'l Joint Research (1 results) Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 3 results) Presentation (8 results) (of which Int'l Joint Research: 8 results,  Invited: 2 results) Remarks (2 results)

  • [Int'l Joint Research] The University of Chicago(米国)2019

    • Year and Date
      2019-03-15
    • Related Report
      2021 Annual Research Report
  • [Journal Article] Theta Dynamics Contribute to Retrieving Motor Plans after Interruptions in the Primate Premotor Area2021

    • Author(s)
      Hosaka Ryosuke、Watanabe Hidenori、Nakajima Toshi、Mushiake Hajime
    • Journal Title

      Cerebral Cortex Communications

      Volume: 2 Issue: 4

    • DOI

      10.1093/texcom/tgab059

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Forelimb movements evoked by optogenetic stimulation of the macaque motor cortex2020

    • Author(s)
      Watanabe H, Sano H, Chiken S, Kobayashi K, Fukata Y, Fukata M, Mushiake H, Nambu A
    • Journal Title

      Nat Commun

      Volume: 11 Issue: 1 Pages: 3253-3253

    • DOI

      10.1038/s41467-020-16883-5

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Forelimb movements evoked by optogenetic stimulation of the macaque motor cortex2019

    • Author(s)
      Hidenori Watanabe, Hiromi Sano, Satomi Chiken, Kenta Kobayashi, Yuko Fukata, Masaki Fukata, Hajime Mushiake, Atsushi Nambu
    • Journal Title

      bioRxiv

      Volume: -

    • DOI

      10.1101/2019.12.13.876219

    • Related Report
      2019 Research-status Report
    • Open Access
  • [Presentation] 3D microelectrode array with optical stimulation for modulating neural network dynamics in the monkey motor cortex during a reaching task2022

    • Author(s)
      Hidenori Watanabe, Kazutaka Takahashi, Kenta Kobayashi, Nicholas G. Hatsopoulos, Hajime Mushiake
    • Organizer
      The 99th Annual Meeting of the Physiological Society of Japan
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Spatiotemporal dynamics of beta oscillation phase in the monkey motor cortex.2019

    • Author(s)
      Hidenori Watanabe, Kazutaka Takahashi, Hajime Mushiake.
    • Organizer
      Neural Oscillation Conference 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Sensorimotor integration for cued reaching movements through multiple bands of cortical oscillations from the motor and somatosensory cortices2019

    • Author(s)
      Kazutaka Takahashi, Hidenori Watanabe, Masaki Makitani, Hajime Mushiake.
    • Organizer
      Society for Neuroscience Annual Meeting
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 3D recordings using the Matrix Array2019

    • Author(s)
      Hidenori Watanabe, Kazutaka Takahashi, Hajime Mushiake
    • Organizer
      Society for Neuroscience Annual Meeting
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Three dimensional dynamics of β oscillation phase in the monkey motor cortex during a reaching task2019

    • Author(s)
      Hidenori Watanabe, Kazutaka Takahashi, Hajime Mushiake
    • Organizer
      Society for Neuroscience Annual Meeting
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Phase Locking of β Oscillation in the Monkey Motor Cortical Areas2018

    • Author(s)
      Hidenori Watanabe, Hajime Mushiake, Kazutaka Takahashi
    • Organizer
      The 41st Annual Meeting of the Japan Neuroscience Society
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Increasing LFP theta power reflects protecting motor plans from an interruption in primate motor areas2018

    • Author(s)
      Ryosuke Hosaka, Hidenori Watanabe, Toshi Nakajima, Hajime Mushiake
    • Organizer
      The 41st Annual Meeting of the Japan Neuroscience Society
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Increasing LFP theta power reflects protecting motor plans from an interruption in primate motor areas2018

    • Author(s)
      Ryosuke Hosaka, Hidenori Watanabe, Toshi Nakajima, Hajime Mushiake
    • Organizer
      11th Federation of European Neuroscience Societies forum
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Remarks] 2021年 生体システム生理学研究実績

    • URL

      http://www.neurophysiology.med.tohoku.ac.jp/work/work03/work03_2021.html

    • Related Report
      2021 Annual Research Report
  • [Remarks] 神経細胞を光によって操作し、サルの手を動かすことに成功

    • URL

      https://www.tohoku.ac.jp/japanese/2020/06/press20200626-01-hand.html

    • Related Report
      2021 Annual Research Report

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Published: 2018-01-25   Modified: 2023-01-30  

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