| Outline of Final Research Achievements |
Loss or mutation of YggS/PROSC protein, a pyridoxal phosphate (PLP)-binding protein, disrupts a wide variety of metabolic systems, especially amino acid and vitamin B6 metabolism. This study has demonstrated that the YggS/PPROSC protein plays an important role in the homeostasis of vitamin B6, especially pyridoxine phosphate (PNP), in various organisms. In E. coli, the abnormal accumulation of PNP inhibits the glycine cleavage system and various metabolic pathways, including amino acid metabolism. The present study suggests that the YggS/PROSC protein may be involved in the conversion process between PLP and pyridoxamine phosphate (PMP).
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