| Outline of Final Research Achievements |
To elucidate the function of long non-coding RNAs that regulate innate immune responses and their nuclear metabolic control in mammalian cells, we conducted international collaborative research with Dr. Torben in Denmark, an expert in nuclear RNA degradation mechanisms, and Dr. Atasoy in the United States, an expert in immune responses. As a result, we discovered that the nuclear degradation of NEAT1, a long non-coding RNA that regulates innate immune responses, is controlled by hnRNPH, a nucler RNA binding protein. We have published our findings in a scientific journal. Furthermore, we also discovered a new mechanism related to the nuclear degradation of messenger RNA and are currently continuing our collaborative research.
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