| Outline of Final Research Achievements |
DEL-1 is constitutively produced by osteoclasts and vascular endothelial cells, and has been found to have a variety of functions, including inhibition of osteoclasts, effects on bone metabolism and mesenchymal stem cells, and induction of regulatory T cells. It is highly possible that DEL-1 is related to the aging process, as it decreases with inflammation and aging. Studies on two mucosal diseases, periodontitis and pneumonia, have revealed the mechanism of action of DEL-1 on osteoclasts and osteoblasts and the regulation of DEL-1 expression. Collaborative research with overseas researchers who have various disease models for DEL-1 has led to a dramatic development of our research.
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