| Outline of Final Research Achievements |
The purpose of this study was to clarify the mechanisms by which social factors lead to the development of atherosclerosis via stress responses in Japan and the UK, which have different cultural and social backgrounds. The study used a Japanese-UK cohort study that followed a wide range of lifestyle habits, biological indicators, and arteriosclerosis indices for more than 10 years. The results showed that α-amylase, a stress-responsive biomarker, has a different response to stress than stress hormones such as cortisol and testosterone, and may differ in its mechanism of involvement in arterial stiffness between Japan and UK. In addition, its effect on atherosclerosis was more pronounced in women, indicating the possibility of a sex-dependent interaction.
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