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International promotion program for toxinological research on venomous animals

Research Project

Project/Area Number 17KK0179
Research Category

Fund for the Promotion of Joint International Research (Fostering Joint International Research)

Allocation TypeMulti-year Fund
Research Field Biological pharmacy
Research InstitutionFukuoka University

Principal Investigator

Aoki-Shioi Narumi  福岡大学, 理学部, 助教 (50510187)

Project Period (FY) 2018 – 2022
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
Keywords蛇毒液 / 阻害剤 / 毒ヘビ / 蛇毒咬傷 / 毒ヘビ咬傷被害 / 抗毒素治療 / 出血毒 / ヘビ毒毒素 / 酵素阻害タンパク質 / 酵素阻害ペプチド / 出血毒金属プロテアーゼ / toxinology / anti-venom antibody / inhibitor / venomous snake / toxin, inhibitor / Toxinology / toxin inhibitor / self-defense system
Outline of Final Research Achievements

The aim of this study was to address the social and academic research issues in the field of snakebite, which claims a significant number of lives globally and necessitates more international collaboration. Additionally, the study aimed to establish a platform for the advancement of snakebite treatment drugs. I had the privilege of attending the International Society on Toxicology (IST) world congress, the most esteemed academic conference in this field. I presented my recent research findings in a positive manner. As a result, I was honored to be chosen as one of the organizing committee members for the upcoming international conference to be held in Singapore. These collaborations have facilitated the development of research initiatives to establish comprehensive databases encompassing the genomes of various snake species worldwide. Furthermore, being a part of the IST community has provided valuable access to the latest and most accurate information.

Academic Significance and Societal Importance of the Research Achievements

本研究は有毒生物研究に関わる研究グループとの国際的な共同研究を通して、信頼関係のある人的ネットワークを築くことに成功した。これは、各地域固有の有毒生物についての情報やデータの共有や共同研究への展開につながっている。有毒生物の研究では、サンプル入手が困難な点が研究の律速となる。本研究では、円滑に自然科学の研究を推進していくため、豊かなアジアの資源を各国の関係者と一緒に保護すると同時に、次世代研究者の育成を考慮した持続可能なプラットフォームの構築を目指してきた。本研究では、有毒生物資源を利用できる環境を整備した。これは、世界の科学者の協力し、最先端の毒ヘビ研究をここ日本国で展開することができる。

Report

(6 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (53 results)

All 2023 2022 2021 2020 2019 2018 Other

All Int'l Joint Research (1 results) Journal Article (13 results) (of which Int'l Joint Research: 8 results,  Peer Reviewed: 13 results,  Open Access: 10 results) Presentation (33 results) (of which Int'l Joint Research: 9 results,  Invited: 3 results) Book (3 results) Remarks (2 results) Funded Workshop (1 results)

  • [Int'l Joint Research] National University of Singapore(Singapore)2019

    • Related Report
      2022 Annual Research Report
  • [Journal Article] Precursor genes of Bowman-Birk-type serine proteinase inhibitors comprise multiple inhibitory domains to promote diversity2023

    • Author(s)
      Aoki-Shioi Narumi、Nagai Yuki、Deshimaru Masanobu、Terada Shigeyuki
    • Journal Title

      Biochimica et Biophysica Acta (BBA) - General Subjects

      Volume: 1867 Issue: 1 Pages: 130248-130248

    • DOI

      10.1016/j.bbagen.2022.130248

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Arabidopsis thaliana endonuclease v is a ribonuclease specific for inosine-containing single-stranded RNA2021

    • Author(s)
      Endo M, Kim JI, Shioi NA, Iwai S, Kuraoka I.
    • Journal Title

      Open Biol.

      Volume: 11 Issue: 10 Pages: 210148-210148

    • DOI

      10.1098/rsob.210148

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] An arrhythmic mutation E7K facilitates TRPM4 channel activation via enhanced PIP2 interaction2021

    • Author(s)
      Hu Yaopeng、Li Qin、Kurahara Lin-Hai、Shioi Narumi、Hiraishi Keizo、Fujita Takayuki、Zhu Xin、Inoue Ryuji
    • Journal Title

      Cells

      Volume: 10 Issue: 5 Pages: 983-983

    • DOI

      10.3390/cells10050983

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Isolation and functional diversity of Bowman–Birk type serine proteinase inhibitors from Hyacinthus orientalis2021

    • Author(s)
      Aoki-Shioi Narumi、Terada Shigeyuki、Hellinger Roland、Furuta Yoshitaka、Gruber Christian W.
    • Journal Title

      Biochemical Journal

      Volume: 478 Issue: 6 Pages: 1287

    • DOI

      10.1042/bcj20201005

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Unusual quaternary structure of a homodimeric synergistic-type toxin from mamba snake venom defines its molecular evolution2020

    • Author(s)
      Aoki-Shioi Narumi、Jobichen Chacko、Sivaraman J.、Kini R. Manjunatha
    • Journal Title

      Biochemical Journal

      Volume: 477 Issue: 20 Pages: 3951

    • DOI

      10.1042/bcj20200529

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Eicosapentaenoic acid ameliorates pulmonary hypertension via inhibition of tyrosine kinase Fyn2020

    • Author(s)
      Kurahara Lin Hai、Hiraishi Keizo、Yamamura Aya、Zhang Ying、Abe Kohtaro、Yahiro Eiji、Aoki Mikiko、Koga Kaori、Yokomise Hiroyasu、Go Tetsuhiko、Ishikawa Kaori、Bo Zhang、Kishi Hiroko、Kobayashi Sei、Aoki-Shoi Narumi、Toru Satoh、Inoue Ryuji、Hirano Katsuya
    • Journal Title

      Journal of Molecular and Cellular Cardiology

      Volume: 148 Pages: 50

    • DOI

      10.1016/j.yjmcc.2020.08.013

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cysteine-Rich Secretory Proteins (CRISPs) From Venomous Snakes: An Overview of the Functional Diversity in A Large and Underappreciated Superfamily2020

    • Author(s)
      Takashi Tadokoro, Cassandra M. Modahl, Katsumi Maenaka, Narumi Aoki-Shioi
    • Journal Title

      Toxins

      Volume: 12 Issue: 3 Pages: 175-175

    • DOI

      10.3390/toxins12030175

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Natural inhibitors of snake venom metalloproteinases2020

    • Author(s)
      Narumi Aoki-Shioi, Cho Yeow Koh and R. Manjunatha Kini
    • Journal Title

      Australian Journal of Chemistry

      Volume: 73 Issue: 4 Pages: 277

    • DOI

      10.1071/ch19414

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Omics Technologies for Profiling Toxin Diversity and Evolution in Snake Venom: Impacts on the Discovery of Therapeutic and Diagnostic Agents2020

    • Author(s)
      Cassandra M. Modahl, Rajeev Brahma, Cho Yeow Koh, Narumi Shioi and R. Manjunatha Kini
    • Journal Title

      Annual Review of Animal Biosciences

      Volume: 8 Issue: 1 Pages: 91

    • DOI

      10.1146/annurev-animal-021419-083626

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effects of acetaldehyde-induced DNA lesions on DNA metabolism2020

    • Author(s)
      Haruka Tsuruta, Yuina Sonohara, Kosuke Tohashi, Narumi Aoki Shioi, Shigenori Iwai and Isao Kuraoka
    • Journal Title

      Genes and Environment

      Volume: 42 Issue: 1 Pages: 1-1

    • DOI

      10.1186/s41021-019-0142-7

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Adaptation and diversification of venomous snake proteins2019

    • Author(s)
      Narumi Aoki-Shioi
    • Journal Title

      The Nucleus

      Volume: 62 Issue: 2 Pages: 165

    • DOI

      10.1007/s13237-019-00270-7

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Crystal structure of the complex between venom toxin and serum inhibitor from Viperidae snake2018

    • Author(s)
      Shioi Narumi、Tadokoro Takashi、Shioi Seijiro、Okabe Yuki、Matsubara Haruki、Kita Shunsuke、Ose Toyoyuki、Kuroki Kimiko、Terada Shigeyuki、Maenaka Katsumi
    • Journal Title

      Journal of Biological Chemistry

      Volume: 294 Issue: 4 Pages: 1250

    • DOI

      10.1074/jbc.ra118.006840

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Oligo swapping method for in vitro DNA repair substrate containing a single DNA lesion at a specific site 06 Biological Sciences 0601 Biochemistry and Cell Biology 06 Biological Sciences 0604 Genetics2018

    • Author(s)
      Yukutake Mika、Hayashida Mika、Shioi Aoki Narumi、Kuraoka Isao
    • Journal Title

      Genes and Environment

      Volume: 40 Issue: 1 Pages: 23-31

    • DOI

      10.1186/s41021-018-0112-5

    • URL

      https://pure.teikyo.jp/en/publications/a2329533-f893-48fa-944c-fcb60492928a

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] ハブ血清タンパク質Small serum proteins-4の標的毒素の同定2022

    • Author(s)
      大瀬良碧、倉岡功、塩井(青木)成留実
    • Organizer
      令和4年度日本生化学会 九州支部例会
    • Related Report
      2022 Annual Research Report
  • [Presentation] マンバスネーク毒の相乗効果を担う毒素の同定と構造解析2022

    • Author(s)
      塩井(青木)成留実、Sivaraman,J, R.Manjunatha,KINI
    • Organizer
      第68回トキシンシンポジウム
    • Related Report
      2022 Annual Research Report
  • [Presentation] ヘビ毒Phosphodiesteraseの環状DNA基質における作用メカニズム解析2022

    • Author(s)
      塩井(青木)成留実、四ケ所亮輔、三原大輝、倉岡功
    • Organizer
      日本環境変異原ゲノム学会第51回大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 抗出血因子HSFの細胞発現系構築およびヘビ毒素の結合ドメインの同定2022

    • Author(s)
      三原 大輝, 倉岡 功, 塩井 (青木) 成留実
    • Organizer
      第95回日本生化学会大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] ヘビ血清由来Fetuin family proteinの新規結合タンパク質の同定2022

    • Author(s)
      塩井(青木)成留実、堤 陸、三原 大輝、倉岡 功
    • Organizer
      第95回日本生化学会大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Synergistictoxins from mamba snake venom; structural insight into evolution of three finger toxin family2022

    • Author(s)
      Narumi Aoki-Shioi, Chacko Jobichen, J. Sivaraman and R. Manjunatha Kini
    • Organizer
      2022 Venom Evolution, Function and Biomedical Applications Gordon Research Conferences
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Crystal structure of synergistic-type toxin from Dendroaspis(mamba) venom shows a unique quaternary structure of three finger toxin family2022

    • Author(s)
      Narumi Aoki-Shioi,Chacko Jobichen, J. Sivaraman and R. Manjunatha Kini
    • Organizer
      21st World Congress of the International Society on Toxinology (IST)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Identification of inhibitory regions of Small serum protein-4 (SSP-4) against vascular apoptosis-inducing snake venom metalloprotease2021

    • Author(s)
      Aoi Osera,Risa Mutoh, Isaokuraoka, NarumiAoki-Shioi
    • Organizer
      11th Asia-Pacific Congress of the International Society on Toxinology
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] ヘビ出血毒を阻害するラクダ科H鎖抗体可変部の発現系構築とその活性評価2021

    • Author(s)
      大瀬良碧、小倉彩香、塩井(青木)成留実、香田悠樹、橋口周平、村上明一
    • Organizer
      第94回日本生化学会大会
    • Related Report
      2021 Research-status Report
  • [Presentation] 環状DNAに対するヘビ毒Phosphodiesteraseの特異的切断活性2021

    • Author(s)
      四ヶ所亮輔、財津佳史、倉岡功、塩井(青木)成留実
    • Organizer
      第94回日本生化学会大会
    • Related Report
      2021 Research-status Report
  • [Presentation] コブラ科毒由来synergistic toxinのユニークな立体構造2021

    • Author(s)
      塩井(青木)成留実、倉岡功、キニ・マンジュナタ
    • Organizer
      第94回日本生化学会大会
    • Related Report
      2021 Research-status Report
  • [Presentation] コブラ科(Najaatra) Phosphodiesteraseのエンドヌクレアーゼとしての性質と発現系構築2021

    • Author(s)
      四ヶ所亮輔、財津佳史、倉岡功、塩井(青木)成留実
    • Organizer
      日本環境変異原ゲノム学会第50回記念大会
    • Related Report
      2021 Research-status Report
  • [Presentation] 毒液中と血液中の Cysrich-secretory proteins (CRISP)の構造と機能について2021

    • Author(s)
      塩井(青木)成留実、胡耀鵬、平石敬三、倉原琳、中山明日香、倉岡功
    • Organizer
      第67回トキシンシンポジウム
    • Related Report
      2021 Research-status Report
  • [Presentation] 毒ヘビ血清由来抗出血因子のコブラ毒に対する特異的結合2020

    • Author(s)
      四ヶ所 亮輔、堤 陸、倉岡 功、塩井(青木)成留実
    • Organizer
      第93回日本生化学会大会
    • Related Report
      2020 Research-status Report
  • [Presentation] 松原 一樹、倉岡 功、竹立 新人、塩井 成留実2020

    • Author(s)
      DNA修復経路のためのT7endonuclase1の新たな機能
    • Organizer
      第93回日本生化学会大会
    • Related Report
      2020 Research-status Report
  • [Presentation] 毒ヘビ中のCysteine-Rich Secretory Proteins (CRISPs) toxinとnon-venom CRIPSの構造と機能の共通性と相違について2020

    • Author(s)
      塩井(青木)成留実、堤陸、中山明日香、重松毅、倉岡功
    • Organizer
      第93回日本生化学会大会
    • Related Report
      2020 Research-status Report
  • [Presentation] クサリヘビ科およびコブラ科のヘビ毒由来のエンドヌクレアーゼ活性の性質比較2020

    • Author(s)
      四ヶ所 亮輔、堤 陸、 松原 一樹、 倉岡 功、 塩井(青木) 成留実
    • Organizer
      日本環境変異原学会第49回大会
    • Related Report
      2020 Research-status Report
  • [Presentation] Regulation system of snake toxin proteins2019

    • Author(s)
      Narumi Aoki-shioi
    • Organizer
      The 1st NUS-FU-KU Joint Symposium on Biochemistry in FUKUOKA
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Developing towards anti-venom drugs by endogenous inhibitor against the metalloproteinase induced hemorrhage; Rational design of drug and therapeutic potential for snakebite2019

    • Author(s)
      Ayaka Ogura, Yoshifumi Zaitsu, Riku Tsutsumi, Isao Kuraoka, R Manjunatha Kini, Narumi Aoki-Shioi
    • Organizer
      The 20th World Congress of the International Society on Toxinology Congress
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Accelerated evolution of snake toxin genes; accumulated gene mutation in exons2019

    • Author(s)
      Narumi Aoki-Shioi and Isao Kuraoka
    • Organizer
      he 19th All India Congress of Genetics and Genomics at IICB
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 有毒生物が備える自己の毒耐性システムの解明2019

    • Author(s)
      塩井(青木)成留実
    • Organizer
      2019年度日本生化学会九州支部例会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 毒ヘビがもつ毒素阻害分子の同定とその応用2019

    • Author(s)
      堤陸、塩井成留実、倉岡功
    • Organizer
      2019年度日本生化学会九州支部例会
    • Related Report
      2019 Research-status Report
  • [Presentation] ヘビ毒核酸分解酵素の基質特異性2019

    • Author(s)
      財津佳史、塩井成留実、倉岡功
    • Organizer
      2019年度日本生化学会九州支部例会
    • Related Report
      2019 Research-status Report
  • [Presentation] ヘビ毒ホスホジエステラーゼの基質DNA配列の優先性2019

    • Author(s)
      財津 佳史、塩井 成留実、倉岡 功
    • Organizer
      第6回アジア環境変異原学会・日本環境変異原学会第48回大会合同大会
    • Related Report
      2019 Research-status Report
  • [Presentation] アセトアルデヒドによるヒストンテールへの影響2019

    • Author(s)
      堤陸、 四ケ所亮輔、小倉彩香、倉岡 功、塩井 成留実
    • Organizer
      第6回アジア環境変異原学会・日本環境変異原学会第48回大会合同大会
    • Related Report
      2019 Research-status Report
  • [Presentation] Structure-function relationship on snake toxin and its endogenous inhibitor2019

    • Author(s)
      Narumi Aoki-Shioi, Takashi Tadokoro, Yaopeng Hu, Lin Kurahara, Katsumi Maenaka
    • Organizer
      JSCB_PSSJ2019
    • Related Report
      2019 Research-status Report
  • [Presentation] Why are venomous snakes not killed with by their own venom?2018

    • Author(s)
      Narumi Aoki-Shioi, Yasuyoshi Tanaka, Masanobu Deshimal, Isao Kuraoka, R Manjunatha KINI
    • Organizer
      Gordon Research Conference- Venom Evolution, Function and Biomedical Applications-
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Therapeutic potential of an endogenous inhibitor of hemorrhage induced by snake venom metalloproteinase2018

    • Author(s)
      Ayaka Ogura, Yoshifumi Zaitsu, Makoto Kato, Toru Hirano, Isao Kuraoka, R Manjunatha Kini, Narumi Aoki-Shioi
    • Organizer
      Nextgen Genomics Biology Bioinformatics and Technologiyes Conference
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Rational design and development of anti-venom drugs for snakebites based on the endogenous inhibitors from Japanese Viper2018

    • Author(s)
      Ayaka Ogura, Yoshifumi Zaitsu, Keizo Hiraishi, Isao Kuraoka, R Manjunatha KINI, Narumi Shioi_Aoki
    • Organizer
      International Society of toxicology in 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] コブラ科毒液中の成分分析とその阻害因子の探索2018

    • Author(s)
      小倉 彩香、堤 陸、塩井 成留実、倉岡 功
    • Organizer
      平成30年度日本生化学会九州支部例会
    • Related Report
      2018 Research-status Report
  • [Presentation] ヘビ毒核酸分解酵素の精製と基質特異性2018

    • Author(s)
      財津佳史、塩井成留実、倉岡功
    • Organizer
      平成30年度日本生化学会九州支部例会
    • Related Report
      2018 Research-status Report
  • [Presentation] 毒ヘビ由来Ca2+チャネル阻害型神経毒と毒ヘビ血清蛋白質の複合体構造2018

    • Author(s)
      田所 高志、塩井(青木)成留実、岡部 由紀、松原 永季、喜多 俊介
    • Organizer
      第18回日本蛋白質科学会年次大会
    • Related Report
      2018 Research-status Report
  • [Presentation] ヘビ毒ADAMであるVAP1の新たな標的の探索2018

    • Author(s)
      新井悠太、塩井成留実、瀬尾忠彦、澤田均、荒木聡彦
    • Organizer
      第65回トキシンシンポジウム
    • Related Report
      2018 Research-status Report
  • [Book] クサリヘビ科毒中の主成分プロテアーゼ毒素について2020

    • Author(s)
      福岡大学理学集報
    • Publisher
      福岡大学研究推進部
    • Related Report
      2020 Research-status Report
  • [Book] Medical Toxicology chapter: Therapeutics Based on Endogenous Inhibitors from Vipers2019

    • Author(s)
      Narumi Aoki-Shioi and Cassandra M. Modahl
    • Publisher
      IntechOpen
    • ISBN
      9781838808273
    • Related Report
      2019 Research-status Report
  • [Book] 実験医学 魅惑的な毒をもつ生物研究へのお誘い2018

    • Author(s)
      塩井(青木)成留実
    • Publisher
      羊土社
    • Related Report
      2018 Research-status Report
  • [Remarks] 福岡大学研究者情報

    • URL

      https://resweb2.jhk.adm.fukuoka-u.ac.jp/FukuokaUnivHtml/info/4944/R108J.html

    • Related Report
      2021 Research-status Report
  • [Remarks] Reserchmap

    • URL

      https://researchmap.jp/Narumi50510187

    • Related Report
      2021 Research-status Report
  • [Funded Workshop] The 1st NUS-FU-KU Joint Symposium on Biochemistry in FUKUOKA2019

    • Related Report
      2019 Research-status Report

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Published: 2018-01-25   Modified: 2025-01-30  

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