| Project/Area Number |
17KT0013
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Multi-year Fund |
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| Section | 特設分野 |
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| Research Field |
Constructive Systems Biology
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| Research Institution | Tohoku University |
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Principal Investigator |
Sugimoto Asako 東北大学, 生命科学研究科, 教授 (80281715)
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| Co-Investigator(Kenkyū-buntansha) |
菊地 泰生 宮崎大学, 医学部, 准教授 (20353659)
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| Project Period (FY) |
2017-07-18 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2019: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2018: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2017: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Keywords | 遺伝子回路 / ゲノム進化 / 線虫 / 細胞極性 / 生殖顆粒 / C.elegans / 遺伝子 / rewiring / C. elegans |
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| Outline of Final Research Achievements |
In this study, we characterized the rewiring of gene circuits using three nematode species (C. elegans, C. inopinata, and P. pacificus), by comparative genomics and gene function analysis. We focused on the gene circuit rewiring of the establishment of cell polarity and germ granule formation in zygotes. We found that the loss or acquisition of key genes led to the rewiring of gene circuits at a high frequency, even in closely related species. In particular, we found a new phenomenon in the process of cell polarity establishment in P. pacificus zygotes; an actin aggregate is involved in the reorientation of the mitotic spindle, which is not observed in C. elegans.
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| Academic Significance and Societal Importance of the Research Achievements |
生物が進化する過程では、生命現象を制御する遺伝子回路の変化が重要だと考えられているが、そのプロセスについては十分な理解が進んでいない。本研究では、３種の近縁の線虫種のゲノム比較と遺伝子操作により、遺伝子の喪失や獲得により個体発生の素過程が予想以上に急激に変化し得ることを明らかにした。これは生物進化プロセスの遺伝子レベルでの理解に貢献する成果である。
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