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Challenges for constitutive analysis of the mechanism of spiculous skeleton construction

Research Project

Project/Area Number 17KT0019
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeMulti-year Fund
Section特設分野
Research Field Constructive Systems Biology
Research InstitutionKyoto University

Principal Investigator

Funayama Noriko  京都大学, 理学研究科, 准教授 (30276175)

Project Period (FY) 2017-07-18 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2019: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Keywords形態形成 / 骨格形成 / 骨片骨格形成 / 骨片運搬 / カワカイメン / 骨片 / 芽球形成 / 芽球骨片 / カイメン動物 / 細胞移動 / 自己組織化 / カイメン / 多様性
Outline of Final Research Achievements

This research proposal consists of three very challenging projects, all of which aim to "further elucidate the mechanism of spiculous skeleton formation" of non-model organisms, sponges. This is our laboratory's original research that has no similar studies in Japan or abroad. The project aimed at elucidating the cellular and molecular mechanisms of "gemmosclere" transport during gemmule formation, we have succeeded in obtaining a set of candidate genes might involve in this process by RNAseq. Other projects could not be carried out as planned due to unexpected technical and biological difficulties, but we were able to obtain many important findings for future research development in the course of our efforts.

Academic Significance and Societal Importance of the Research Achievements

申請者らは非常に独創性の高いカイメン骨片骨格形成機構の研究から、「形作りの要素は細胞」という動物胚の研究によるこれまでの知見とは全く異なる、「細胞は作業員として働き、産生した物体(骨片など)を操作する形作り」という新規コンセプトの形態形成機構を発見した。近年、硬骨魚のヒレ形成でも、同様の機構が働くことが他のグループの研究から明らかになり、この形態形成機構は、動物の形作りの理解を拡張する、発生生物学の教科書に新しい章を開くような研究であると評価いただいている。本研究の成果は、カイメン骨片骨格形成機構のさらなる理解に留まらず、「作業員細胞による形作り機構」の理解に繋がる学術的に重要な知見である。

Report

(6 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (8 results)

All 2020 2019 2018 Other

All Int'l Joint Research (1 results) Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (4 results) (of which Int'l Joint Research: 1 results)

  • [Int'l Joint Research] Australian national University(オーストラリア)

    • Related Report
      2018 Research-status Report
  • [Journal Article] Skeleton construction upon local regression of the sponge body2019

    • Author(s)
      Kishimoto Kouji、Sugano‐Yasunaga Wakana、Taniguchi Atsushi、Agata Kiyokazu、Nonaka Shigenori、Funayama Noriko
    • Journal Title

      Development, Growth & Differentiation

      Volume: 61 Issue: 9 Pages: 485-500

    • DOI

      10.1111/dgd.12636

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Produce, carry/position, and connect: morphogenesis using rigid materials2019

    • Author(s)
      Funayama Noriko
    • Journal Title

      Current Opinion in Genetics & Development

      Volume: 57 Pages: 91-97

    • DOI

      10.1016/j.gde.2019.08.001

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Meeting Report on “At the Roots of Bilaterian Complexity: Insights from Early Emerging Metazoans,” Tutzing (Germany) September 16, 19, 20192019

    • Author(s)
      Funayama Noriko、Frank Uri
    • Journal Title

      BioEssays

      Volume: 42 Issue: 2 Pages: 1900236-1900236

    • DOI

      10.1002/bies.201900236

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Distinct from the morphogenesis based on the reconfiguration of a mass of cells: Morphogenesis in which cells manipulate rigid materials2020

    • Author(s)
      Nakagawa K., Okawa M., Nakazawa J., Kinjyo K., Kondo T*. and ○Funayama, N.
    • Organizer
      第53回 日本発生生物学会
    • Related Report
      2020 Research-status Report
  • [Presentation] Morphogenesis in which cells act as builders to manipulate rigid materials:skeleton construction of sponges2020

    • Author(s)
      Noriko Funayama
    • Organizer
      第43回日本分子生物学会年会
    • Related Report
      2020 Research-status Report
  • [Presentation] Produce, carry/position, and connect:morphogeneisis using rigid materials2019

    • Author(s)
      N. Funayama, K. Nakagawa, K. Kinjyo
    • Organizer
      International Workshop "At the roots of bilaterian complexity:insights from early emerging metazoans"
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Attempt to make a breakthrough for live imaging of cells or proteins, and for gene functional analysis, in sponges by establishing a method for gene introduction2018

    • Author(s)
      Tomonori Mukai, Noriko Funayama
    • Organizer
      第51回 日本発生生物学会
    • Related Report
      2018 Research-status Report

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Published: 2017-07-21   Modified: 2024-12-25  

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