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The evolution of discontinuity as a result of chromosome evolution

Research Project

Project/Area Number 17KT0028
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeMulti-year Fund
Section特設分野
Research Field Constructive Systems Biology
Research InstitutionNational Institute of Genetics

Principal Investigator

Kitano Jun  国立遺伝学研究所, ゲノム・進化研究系, 教授 (80346105)

Project Period (FY) 2017-07-18 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2019: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2018: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2017: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Keywords種分化 / 多様性 / 染色体 / 適応進化 / 魚類 / ゲノム / 適応 / 魚
Outline of Final Research Achievements

We have determined whole genome sequences of over 20 stickleback populations (about 10 fish per population). The coverage for each individual was about x10. Calculation of gene flow rates showed that gene flow rates between different ecotypes varied among systems, suggesting that we have established a system suitable for studying the speciation continuum. We also found a strong positive correlation between the recombination rates and the gene flow rates, suggesting the importance of recombination suppression for reproductive isolation. We also found that the genomic region responsible for adaptive phenotypic divergence showed higher genetic differentiation than other regions. We also identified several chromosomal structural changes.

Academic Significance and Societal Importance of the Research Achievements

生物に見られる重要な特徴の一つは種分化である。種分化とは一つの共通祖先から、枝分かれによって分化した集団が生じ、生殖隔離によって違いが維持されるに至る連続的な過程である。換言すると、生物が多様化しつつ、均一なものへとマージしてしまわない仕組みの解明が、生命の理解に必須である。研究代表者らはこのような連続的な種分化過程を研究するのに最適な系を確立した。また、種分化を促進する要因として組換え抑制の進化が重要であることを示した。これら組換え抑制の進化に染色体構造変化が関与していそうである。本成果は、種分化を促進する要因に、重要な洞察を与える。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (6 results)

All 2020 2019 2017

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (3 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results)

  • [Journal Article] Genome-wide patterns of divergence and introgression after secondary contact between Pungitius sticklebacks.2020

    • Author(s)
      Yamasaki, Y.Y., Kakioka, R., Takahashi, H., Toyoda, A., Nagano, A. J., Machida, Y., Moller, P.R., and Kitano, J.
    • Journal Title

      Philosophical Transactions of the Royal Society B: Biological Sciences

      Volume: in press

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differences in the contributions of sex-linkage and androgen regulation to sex-biased gene expression in juvenile and adult sticklebacks.2020

    • Author(s)
      Kitano, J., Kakioka, R., Ishikawa, A., Toyoda, A., and Kusakabe, M.
    • Journal Title

      Journal of Evolutionary Biology

      Volume: in press

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Armor plate diversity in Japanese freshwater threespine sticklebacks2019

    • Author(s)
      Yamasaki, Y.Y., Mori, S., Kokita, T., and Kitano, J.
    • Journal Title

      Evolutionary Ecology Research

      Volume: 20 Pages: 51-67

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed
  • [Presentation] トゲウオにおける適応放散の遺伝機構2019

    • Author(s)
      北野潤
    • Organizer
      日本遺伝学会分科会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Genomic signatures of introgression at the late stage of stickleback speciation2017

    • Author(s)
      Jun Kitano, Mark Ravinet, Asano Ishikawa, Kohta Yoshida, Ryo Kakioka
    • Organizer
      European Society of Evolutionary Biology 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] A key role for an omega-3 fatty acid desaturase in stickleback freshwater colonization2017

    • Author(s)
      Jun Kitano, Asano Ishikawa
    • Organizer
      Society for Molecular Biology and Evolution 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research

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Published: 2017-07-21   Modified: 2021-02-19  

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