| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2019: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2018: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2017: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
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| Outline of Final Research Achievements |
Macrophages exhibit diverse phenotypes and functions. For instance, macrophages play pivotal roles from the beginning of chronic inflammation to the phase of tissue remodeling and dysfunction in noncommunicable diseases, including cardiovascular disease and cancer. It is likely that dysfunction in macrophages would lead to tissue dysfunction in aging and various diseases. In this study, we aimed to elucidate as to how macrophage diversity is regulated by intracellular and extracellular cues. We mainly focused on the changes in the epigenome and at the single-cell level. We found that aging-associated changes in tissue macrophages may alter tissue homeostasis in the heart.
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