Diversity of macrophages in noncommunicable disease
| Project/Area Number |
17KT0047
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Multi-year Fund |
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| Section | 特設分野 |
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| Research Field |
Complex Systems Disease Theory
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| Research Institution | Chiba University |
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Principal Investigator |
Manabe Ichiro 千葉大学, 大学院医学研究院, 教授 (70359628)
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| Project Period (FY) |
2017-07-18 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2019: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2018: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2017: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
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| Keywords | マクロファージ / 生活習慣病 / エピジェネティクス / 慢性炎症 / 心不全 / 肥満 |
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| Outline of Final Research Achievements |
Macrophages exhibit diverse phenotypes and functions. For instance, macrophages play pivotal roles from the beginning of chronic inflammation to the phase of tissue remodeling and dysfunction in noncommunicable diseases, including cardiovascular disease and cancer. It is likely that dysfunction in macrophages would lead to tissue dysfunction in aging and various diseases. In this study, we aimed to elucidate as to how macrophage diversity is regulated by intracellular and extracellular cues. We mainly focused on the changes in the epigenome and at the single-cell level. We found that aging-associated changes in tissue macrophages may alter tissue homeostasis in the heart.
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| Academic Significance and Societal Importance of the Research Achievements |
現在問題となっている心不全や糖尿病を始めとする生活習慣病全般に慢性炎症が寄与していることが明らかとなっている。また、加齢関連疾患も慢性炎症が推進することが示唆されている。本研究の成果は、マクロファージには多様性があること、その多様性は組織、疾患によって異なること、また老化も多様性を変化させることを明らかにした。多様性の変化は組織の機能を損なうと考えられる。多様性を制御するメカニズムの理解は、新たな加齢関連疾患の治療法開発へと結びつくと期待できる。
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Report
(4 results)
Research Products
(19 results)
