DDS treatment strategy by elucidation and control of Nano Eruption
| Project/Area Number |
17KT0048
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Multi-year Fund |
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| Section | 特設分野 |
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| Research Field |
Complex Systems Disease Theory
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Matsumoto Yu 東京大学, 医学部附属病院, 講師 (80548553)
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| Project Period (FY) |
2017-07-18 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2020: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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| Keywords | 生体イメージング / ナノテクノロジー |
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| Outline of Final Research Achievements |
We have recently discovered that the extravasation and permeation of polymeric micelles occur in a dynamic manner characterized by vascular bursts followed by a brief and vigorous outward flow of fluid (called "nano-eruptions"). By using compounds that affect the intratumoral environment, i.e. a TGF-beta inhibitor and chloroquine, the possibility of manipulating nano-eruptions to improve delivery efficiency was investigated. The results indicate that TGF-beta inhibition and chloroquine refashion the intratumoral distribution of DDSs by different mechanisms.
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| Academic Significance and Societal Importance of the Research Achievements |
Nano eruptionを促進あるいは抑制する薬剤を組み合わせることにより、新しいDDS治療戦略の構築が可能となる。
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Report
(5 results)
Research Products
(49 results)
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[Journal Article] Polyplex micelle installing intracellular self-processing functionalities without free catiomers for safe and efficient systemic gene therapy through tumor vasculature targeting2016
Author(s)
Q. Chen, K. Osada, Z. Ge, S. Uchida, T. A. Tockary, A. Dirisala, A. Matsui, K. Toh, K. M. Takeda, X. Liu, T. Nomoto, T. Ishii, M. Oba, Y. Matsumoto, K. Kataoka
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Journal Title
Biomaterials
Volume: 113
Pages: 253-265
DOI
Related Report
Peer Reviewed
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[Presentation] Manipulation of Tumor Vascular Bursts2017
Author(s)
Matsumoto Y, Inoue Y, Toh K, Miyano K, Cabral H, Igarashi K, Iwasaki S, Yamasoba T, Kataoka K
Organizer
14th Taiwan-Japan Conference on Otolaryngology-Head and Neck Surgery
Related Report
Int'l Joint Research / Invited
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