| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2019: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2018: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2017: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Outline of Final Research Achievements |
Recent studies have shown that the frequency of tumorigenesis is increased by multiple gene mutations, but the gene sets have not been fully identified. In this study, we aimed to comprehensively find a novel set of cancer driver genes by multiple gene knocking down by using CRISPR-Cas9 and Xenopus as a model animal. We also aimed to analyze the gene expression profile in tumor tissues. As a result, the assay system using Xenopus was established, and a novel gene set showing a tumor-specific decrease was found.
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