| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
To elucidate the mechanisms of mechano-response (force reception and response) for the regulation of the morphology in multicellular tissues, we studied the developmental processes of various fetal murine organs using imaging techniques and mathematical models. Using the epididymis, we have revealed the mechanism by which the diameter of the epithelial tube is maintained by the active rearrangement of surrounding cells in response to cell division along the circumferential direction of the epithelial tube. We also focused on the force-responsive MAP kinase/ERK, and performed FRET (fluorescence resonance energy transfer) imaging measurements to evaluate ERK activity, revealing a mechanism by which dynamic behaviors of ERK-activated cells contribute to morphogenesis during lung and inner ear development.
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