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癌転移・骨髄依存薬物耐性の動的超分子機構解明のケミカルプローブ創出と創薬展開

Research Project

Project/Area Number 18015027
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionKyoto University

Principal Investigator

藤井 信孝  Kyoto University, 薬学研究科, 教授 (60109014)

Co-Investigator(Kenkyū-buntansha) 大野 浩章  京都大学, 薬学研究科, 准教授 (30322192)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥10,300,000 (Direct Cost: ¥10,300,000)
Fiscal Year 2007: ¥5,300,000 (Direct Cost: ¥5,300,000)
Fiscal Year 2006: ¥5,000,000 (Direct Cost: ¥5,000,000)
Keywords構造活性相関 / GPR54 / ケモカイン / 癌 / CXCR4 / SDF-1 / Eg5 / 薬剤耐性 / Kisspeptin
Research Abstract

平成18年度に引き続き、選択的CXCR4アンタゴニストT140を基本骨格とする蛍光標識プローブの開発を行った。TZ14011のD-Lys8をFluorescein、AlexaFluro488で蛍光標識した誘導体は、親化合物の受容体に対する結合親和性を維持しているとともに、CXCR4受容体を発現する細胞株の細胞表面を有意に蛍光標識することが可能であることを明らかにした。また、本蛍光プローブは、共焦点レーザー顕微鏡での染色実験、フローサイトメーターでの細胞の分析・分画に利用可能であることが示唆された。
環状ペンタペプチドFC131をリードとしたCXCR4アンタゴニストの低分子化・非ペプチド化研究を行い、FC131のファルマコフォアを含むペプチドミメティクスが中程度の受容体結合阻害活性を示すことを明らかにした。また、環状ペプチドの中心骨格をいわゆる「ドラッグライク」な化学構造に置き換えた各種誘導体を合成・評価し、インドールを中心骨格とする新規低分子CXCR4アンタゴニストを見出した。いずれの誘導体もμMレベルでの活性値であることから、抗がん剤や腫瘍転移抑制剤としての応用のためにはさらなる高活性化が望まれるものの、構造展開を行う上でのリード化合物として適当な分子骨格の化合物を見出すことができた。
多因子疾患である癌および白血病に対する治療薬の開発、および、白血球細胞等の細胞分裂を解析するためのケミカルプローブの開発を目的として、細胞分裂のG2/M期において染色体の均等分配に関わるキネシンEg5に対して阻害活性を示す保護システイン誘導体の構造活性相関研究を行った。その結果、4-メトキシトリチルシステインが従来知られていたSTLCに比べて約10倍強力なEg5阻害活性を示すことを明らかにした。

Report

(2 results)
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (74 results)

All 2008 2007 2006 Other

All Journal Article (40 results) (of which Peer Reviewed: 22 results) Presentation (28 results) Book (1 results) Remarks (1 results) Patent(Industrial Property Rights) (4 results)

  • [Journal Article] Modulation of network-driven. GABA-mediated giant depolarizing potentials by SDF-lalpha in the developing hippocampus.2008

    • Author(s)
      Kasiyanov A., et. al.
    • Journal Title

      Dev. Neurosci. (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis and application of fluorescein-and botin-labeled molecular probes for chemokine receptor CXCR4.2008

    • Author(s)
      Oishi S., et. al.
    • Journal Title

      ChemBioChem. (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Facile synthesis of 3- (aminomethyl) isoquinolines by copper-catalysed domino four-component coupling and cyclisation.2008

    • Author(s)
      Ohta Y., et. al.
    • Journal Title

      Chem. Commun. 7

      Pages: 835-837

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of peptide-targeted lipoplexes to CXCR4-expressing rat glioma cells and rat proliferating endothelial cells.2008

    • Author(s)
      Driessen W. H., et. al.
    • Journal Title

      Mol. Ther. 16

      Pages: 516-524

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure-activity relationship study and NMR analysis of fluorobenzoyl pentapeptide GPR54 agonists.2008

    • Author(s)
      Tomita K., et. al.
    • Journal Title

      Biopolymers (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Direct construction of bicyclic heterocycles by palladium-catalyzed domino cyclization of propargyl bromides.2008

    • Author(s)
      Ohno H., et. al.
    • Journal Title

      Ore. Lett. (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Palladium-catalyzed sp3 C-H activation of simple alkyl groups: direct preparation of indoline derivatives from N-alkyl-2-bromoanilines.2008

    • Author(s)
      Watanabe T., et. al.
    • Journal Title

      Org. Lett. (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Design and synthesis of all diastereomers of cyclic pseudo-dipeptides as mimics of cyclic CXCR4 pentapeptide antagonists.2007

    • Author(s)
      Cluzeau J., et. al.
    • Journal Title

      Org. Biomol. Chem. 5

      Pages: 1915-1923

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis and biological evaluation of L-cysteine derivatives as mitotic kinesin Eg5 inhibitors.2007

    • Author(s)
      Ogo N., et. al.
    • Journal Title

      Bioorg. Med. Chem. Lett. 17

      Pages: 3921-3924

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A highly regio- and stereoselective formation of bicyclo [4.2.0] oct-5-ene derivatives through thermal intramolecular [2+2] cycloaddition of allenes.2007

    • Author(s)
      Ohno H., et. al.
    • Journal Title

      J. Org. Chem. 72

      Pages: 4378-4389

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] SAR and QSAR studies on the N-terminally acylated pentapeptide agonists for GPR54.2007

    • Author(s)
      Tomita K., et. al.
    • Journal Title

      J. Med. Chem. 50

      Pages: 3222-3228

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CXCL12-CXCR4 engagement is required for migration of cutaneous dendritic cells.2007

    • Author(s)
      Kabashima K., et. al.
    • Journal Title

      Am. J. Pathol. 171

      Pages: 1249-1257

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heck-type cyclization of oxime ethers: stereoselective carbon-carbonbond formation with aryl halides to produce heterocyclic oximes.2007

    • Author(s)
      Ohno H., et. al.
    • Journal Title

      Angew. Chem. Int. Ed. 46

      Pages: 6325-6328

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CXCR4 engagement promotes dendritic cell survival and maturation.2007

    • Author(s)
      Kabashima K., et. al.
    • Journal Title

      Biochem. Biophys. Res. Commun. 361

      Pages: 1012-1016

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of nucleophosmin negatively regulates CXCR4-mediated Gprotein activation and chemotaxis.2007

    • Author(s)
      Zhang W., et. al.
    • Journal Title

      Mol. Pharmacol. 72

      Pages: 1310-1321

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] One-pot synthesis of carbazoles by palladium-catalyzed N-arylation and oxidative coupling.2007

    • Author(s)
      Watanabe T, et. al.
    • Journal Title

      Chem. Commun. 43

      Pages: 4516-4518

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of plasmacytoid dendritic cells in bone marrow stromal cell niches requires CXCL12-CXCR4 chemokine signaling.2007

    • Author(s)
      Kohara H., et. al.
    • Journal Title

      Blood 110

      Pages: 4153-4160

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gold-catalyzed hydroarylation of allenes: a highly regioselective carbon-carbon bond formation producing six-membered rings.2007

    • Author(s)
      Watanabe T., et. al.
    • Journal Title

      Ore. Lett. 9

      Pages: 4821-4824

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Zipper-mode double C-H activation: palladium-catalyzed direct construction of highly-fused heterocyclic systems.2007

    • Author(s)
      Ohno H., et. al.
    • Journal Title

      Org. Lett. 9

      Pages: 4813-4815

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibitors of the chemokine receptor CXCR4: chemotherapy of AIDS, metastatic cancer, leukemia and rheumatoid arthritis.2007

    • Author(s)
      Tsutsumi H., et. al.
    • Journal Title

      Lett. Drug Design Discov. 4

      Pages: 20-26

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ペプチドをリードとした創薬2007

    • Author(s)
      大石真也, et. al.
    • Journal Title

      蛋白質 核酸 酵素 増刊 ケミカルバイオロジー長野哲雄・長田裕之・菊地和也・上杉志成編集 52

      Pages: 1696-1701

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ケミカルバイオロジーを基盤とするペプチド創薬2007

    • Author(s)
      大石真也, et. al.
    • Journal Title

      遺伝子医学M00K8 ペプチドと創薬 寒川賢治・南野直人編集

      Pages: 87-91

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of low molecular weignt CXCR4 antagonists by exploratory structural tuning of cyclic tetra- and pentapeptide-scaffolds towards the treatment of HIV infection, cancer metastasis and rheumatoid arthritis2007

    • Author(s)
      Tamamura, H., Fujii, N.et al.
    • Journal Title

      Curr Med Chem 14・1

      Pages: 93-102

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Fmoc-based solid-phase synthesis of GPR54-agonistic pentapeptide derivatives containing alkene- and fluoroalkene-dipeptide isosteres.2007

    • Author(s)
      Tomita, K., Ohno, H., Fujii, N.et al.
    • Journal Title

      Biopolymers 88・2

      Pages: 272-278

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Direct Synthesis of 2-(Aminomethyl)indoles through Copper(I)-Catalyzed Domino Three-Component Coupling and Cyclization Reactions.2007

    • Author(s)
      Ohno, H., Fujii, N.et al.
    • Journal Title

      Angew.Chem.Int.Ed.Engl. 46・13

      Pages: 2295-2298

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Structure-activity relationships of cyclic Peptide-based chemokine receptor CXCR4 antagonists : disclosing the importance of side-chain and backbone functionalities.2007

    • Author(s)
      Ueda, S., Ohno, H., Fujii, N.et al.
    • Journal Title

      J.Med.Chem. 50・2

      Pages: 192-198

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Development of copper-mediated allylation of γ-activated-α,β-unsaturated lactam toward peptide mimetic synthesis.2007

    • Author(s)
      Sasaki, T., Fujii, N., Otaka, A.et al.
    • Journal Title

      Tetrahedron Lett. 48・18

      Pages: 3221-3224

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Synthesis of (Z)-alkene-containing cis-proline dipeptide mimetics using samarium(II) diiodide (SmI_2)-mediated reduactive alkylation2007

    • Author(s)
      Sasaki, T., Fujii, N., Otaka, A.et al.
    • Journal Title

      Tetrahedron 63・9

      Pages: 2000-2008

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Direct assessment of CXCR4 mutant conformations reveals complex link between receptor structure and G(alpha)(i) activation.2007

    • Author(s)
      Berchiche, Y.A., Fujii, N., Heveker, N.et al.
    • Journal Title

      J.Biol.Chem. 282・8

      Pages: 5111-5115

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Bromoallenes as allyl dication equivalents in the presence or absence of palladium(O) : direct construction of bicyclic sulfamides containing five- to eight-membered rings by tandem cyclization of bromoallenes.2007

    • Author(s)
      Hamaguchu, H., Ohno, H., Fujii, N., Tanaka, T.et al.
    • Journal Title

      Chem.Eur.J. 13・6

      Pages: 1692-1708

    • Related Report
      2006 Annual Research Report
  • [Journal Article] CXCR4 antagonists mobilize childhood acute lymphoblastic leukemia cells into the peripheral blood and inhibit engraftment.2007

    • Author(s)
      Juarez, J., Fujii, N., Bendall, L.J.et al.
    • Journal Title

      Leukemia (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A Highly Regio- and Stereoselective Formation of Bicyclo[4.2.0]oct-5-ene Derivatives through Thermal Intramolecular [2+2] Cycloaddition2007

    • Author(s)
      Ohno, H., Fujii, N., Tanaka, T.
    • Journal Title

      J.Ore.Chem. (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Identification of a new class of low molecular weight antagonists against the chemokine receptor CXCR4 having the dipicolylamine-zinc(II) complex structure.2006

    • Author(s)
      Tamamura, H., Fujii, N.et al.
    • Journal Title

      J.Med.Chem. 49・11

      Pages: 3412-3415

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Development of a linear type of low molecular weight CXCR4 antagonists based on T140 analogs.2006

    • Author(s)
      Tamamura, H., Fujii, N.et al.
    • Journal Title

      Org.Biomol.Chem. 4・12

      Pages: 2354-2357

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Stereoselective synthesis of (Z)-alkene-containing proline dipeptide mimetics2006

    • Author(s)
      Sasaki, T., Fujii, N., Otaka, A.et al.
    • Journal Title

      J.Org.Chem. 71・13

      Pages: 4969-4979

    • Related Report
      2006 Annual Research Report
  • [Journal Article] The chemokine receptor CXCR4 as a therapeutic target for several disease.2006

    • Author(s)
      Tamamura, H., Tsutsumi, H., Fujii, N.
    • Journal Title

      Mini.Rev.Med.Chem. 6・9

      Pages: 989-995

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Therapeutic potential of the chemokine receptor CXCR4 antagonists as multifunctional agents.2006

    • Author(s)
      Tsutsumi H, Fujii N. et al.
    • Journal Title

      Biopolymers 88・2

      Pages: 279-289

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Structure-activity relationship study on small peptidic GPR54 agonists.2006

    • Author(s)
      Tomita, K., Ohno, H., Fujii, N.et al.
    • Journal Title

      Bioorg.Med.Chem. 45・22

      Pages: 7595-7603

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Synthesis of (Z)-alkene and (E)- fluoroalkene-containing diketopiperazine mimetics utili-zing organocopper-mediated reduction-alkylation and diastereoselectivity examination using DFT calculations2006

    • Author(s)
      Niida, A., Ohno, H., Fujii, N.et al.
    • Journal Title

      J.Org.Chem. 71・11

      Pages: 4118-4129

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A novel one-pot reaction involving organocopper-mediated reduction/transmetalation/asymmetric alkylation, leading to the diastereoselective synthesis of functionalized (Z)-fluoroalkene dipeptide isosteres2006

    • Author(s)
      Narumi, T., Ohno, H., Fujii, N.et al.
    • Journal Title

      Chem.Commun. 45

      Pages: 4720-2722

    • Related Report
      2006 Annual Research Report
  • [Presentation] CXCR4受容体アンタゴニストの蛍光標識体の合成と応用2008

    • Author(s)
      増田亮
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] パラジウム触媒を用いたアレンの連続環化反応によるErgot Alkaloid骨格の一挙構築2008

    • Author(s)
      井貫晋輔
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] シス型アミド結合等価体としてのZ型アルケンおよびE型フルオロアルケンジペプチドイソスターの合成と応用2008

    • Author(s)
      富田健嗣
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] Synthesis of Nitrogen Heterocycles by Palladium-Catalyzed sp3 C-H Activation.2008

    • Author(s)
      Toshiaki Watanabe
    • Organizer
      The 9th Youngnam-Kinki Joint Symposium on Organometallic Chemistry
    • Place of Presentation
      Kyoto
    • Year and Date
      2008-01-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] 新規非ペプチド性ケモカイン受容体CXCR4アンタゴニストの創製研究2007

    • Author(s)
      加藤学
    • Organizer
      第26回メディシナルケミストリーシンポジウム
    • Place of Presentation
      相模原
    • Year and Date
      2007-11-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] シス型アミド結合等価体としてのZ型アルケンおよびE型フルオロアルケンジペプチドイソスターの合成と応用2007

    • Author(s)
      富田健嗣
    • Organizer
      第26回メディシナルケミストリーシンポジウム
    • Place of Presentation
      相模原
    • Year and Date
      2007-11-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] パラジウム触媒を用いたアレンの連続環化反応によるErgot Alkaloid骨格の一挙構築2007

    • Author(s)
      井貫晋輔
    • Organizer
      第27回有機合成若手セミナー
    • Place of Presentation
      京都
    • Year and Date
      2007-11-15
    • Related Report
      2007 Annual Research Report
  • [Presentation] パラジウム触媒カルボニル化反応を用いたトリフルオロメチルアルケンジペプチドイソスター及び類縁体の新規合成法の開発2007

    • Author(s)
      井ノ口恵利子
    • Organizer
      第27回有機合成若手セミナー
    • Place of Presentation
      京都
    • Year and Date
      2007-11-15
    • Related Report
      2007 Annual Research Report
  • [Presentation] CXCR4受容体アンタゴニストの蛍光標識体の合成と応用2007

    • Author(s)
      増田亮
    • Organizer
      第44回ペプチド討論会
    • Place of Presentation
      富山
    • Year and Date
      2007-11-08
    • Related Report
      2007 Annual Research Report
  • [Presentation] パラジウム触媒を用いたプロパルギルブロミドの連続的閉環反応による二環性複素環の一挙構築2007

    • Author(s)
      岡野晃典
    • Organizer
      第33回反応と合成の進歩シンポジウム
    • Place of Presentation
      長崎
    • Year and Date
      2007-11-07
    • Related Report
      2007 Annual Research Report
  • [Presentation] 連続結合形成反応による縮環型芳香族化合物の一挙合成法の開発2007

    • Author(s)
      大野浩章
    • Organizer
      第33回反応と合成の進歩シンポジウム
    • Place of Presentation
      長崎
    • Year and Date
      2007-11-06
    • Related Report
      2007 Annual Research Report
  • [Presentation] パラジウム触媒カルボニル化反応を用いたトリフルオロメチルアルケンジペプチドイソスター及び類縁体の新規合成法の開発2007

    • Author(s)
      井ノ口恵利子
    • Organizer
      第33回反応と合成の進歩シンポジウム
    • Place of Presentation
      長崎
    • Year and Date
      2007-11-05
    • Related Report
      2007 Annual Research Report
  • [Presentation] パラジウム触媒を用いたアレンの連続環化反応によるErgot Alkaloid骨格の一挙構築2007

    • Author(s)
      井貫晋輔
    • Organizer
      第57回日本薬学会近畿支部大会
    • Place of Presentation
      大阪
    • Year and Date
      2007-10-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] インドールを母核とした新規ケモカインレセプターCXCR4アンタゴニストの創製研究2007

    • Author(s)
      加藤学
    • Organizer
      第57回日本薬学会近畿支部大会
    • Place of Presentation
      大阪
    • Year and Date
      2007-10-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] 情報から制御へ:ゲノム情報収斂型創薬科学2007

    • Author(s)
      藤井信孝
    • Organizer
      21COE公開シンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2007-09-20
    • Related Report
      2007 Annual Research Report
  • [Presentation] From Amino Acids to Peptide Isosteres: Implication to Genome-lead drug discovery.2007

    • Author(s)
      Fujii N
    • Organizer
      2. World Congress of Pharmacy and Pharmaceutical Sciences
    • Place of Presentation
      Beijing
    • Year and Date
      2007-09-06
    • Related Report
      2007 Annual Research Report
  • [Presentation] Development of GPR54 agonists as anti-metastasis agents.2007

    • Author(s)
      富田健嗣
    • Organizer
      第八回文部科学省特定領域研究「がん」5領域若手研究者ワークショップ
    • Place of Presentation
      蓼科
    • Year and Date
      2007-08-30
    • Related Report
      2007 Annual Research Report
  • [Presentation] Construction of 2-(Aminomethyl) indole Motif by Cu-catalyzed Multi-component Reaction.2007

    • Author(s)
      Y. Ohta
    • Organizer
      234th ACS meeting & exposition
    • Place of Presentation
      Boston
    • Year and Date
      2007-08-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] Diastereoselective Synthesis of Functionalized (Z)-Fluoroalkene Dipeptide Isosteres: Lys-Lys and Glu-Glu type FADIs.2007

    • Author(s)
      Tetsuo Narumi
    • Organizer
      234th ACS meeting & exposition
    • Place of Presentation
      Boston
    • Year and Date
      2007-08-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] Construction of 2-(Aminomethyl) indole Motif by Cu-catalyzed Multi-component Reaction.2007

    • Author(s)
      Yusuke Ohta
    • Organizer
      14th IUPAC Symposium on Organometallic Chemistry Directed Towards Organic Synthesis
    • Place of Presentation
      Nara
    • Year and Date
      2007-08-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] Synthesis and application of carbazoles by palladium-catalyzed tandem N-arylation and oxidative C-H activation.2007

    • Author(s)
      Toshiaki Watanabe
    • Organizer
      14th IUPAC Symposium on Organometallic Chemistry Directed Towards Organic Synthesis
    • Place of Presentation
      Nara
    • Year and Date
      2007-08-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] One-pot Synthesis of Carbazoles by Palladium-catalyzed N-Arylation and Oxidative Coupling.2007

    • Author(s)
      Shinsuke Inuki
    • Organizer
      6th AFMC International Medicinal Chemistry Symposium
    • Place of Presentation
      Istanbul
    • Year and Date
      2007-07-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] CXCR4 Antagonists; Relevance to Cancer Chemotherapy.2007

    • Author(s)
      Nobutaka Fujii
    • Organizer
      6th AFMC International Medicinal Chemistry Symposium
    • Place of Presentation
      Istanbul
    • Year and Date
      2007-07-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] Synthesis and Application of (Z)-Alkene-and (E)-Fluoroalkene-Dipeptide Isosteres as cis-Amide Equivalents.2007

    • Author(s)
      Tomita K.
    • Organizer
      20th American Peptide Symposium
    • Place of Presentation
      Montreal
    • Year and Date
      2007-06-29
    • Related Report
      2007 Annual Research Report
  • [Presentation] Synthesis and application of carbazoles by palladium-catalyzed tandem N-arylation and oxidative C-H activation.2007

    • Author(s)
      Toshiaki Watanabe
    • Organizer
      Eighth Tetrahedron Symposium
    • Place of Presentation
      Berlin
    • Year and Date
      2007-06-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] Pd触媒を用いたタンデム型N-アリール化-C-H活性化によるカルバゾールの合成と反応機構の考察2007

    • Author(s)
      渡部敏明
    • Organizer
      第5回次世代を担う有機化学シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2007-05-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] 膵臓癌患者における血漿中metastin濃度2007

    • Author(s)
      片桐文彦
    • Organizer
      日本ケミカルバイオロジー研究会第2回年会
    • Place of Presentation
      京都
    • Year and Date
      2007-05-09
    • Related Report
      2007 Annual Research Report
  • [Presentation] シスアミド等価体としての(Z)-アルケンおよび(E)-フルオロアルケンジペプチドイソスターの合成とその応用2007

    • Author(s)
      富田健嗣
    • Organizer
      日本ケミカルバイオロジー研究会第2回年会
    • Place of Presentation
      京都
    • Year and Date
      2007-05-09
    • Related Report
      2007 Annual Research Report
  • [Book] Synthesis by substitution, linear allene, in science of synthesis.2007

    • Author(s)
      Ohno H.
    • Publisher
      Thieme
    • Related Report
      2007 Annual Research Report
  • [Remarks]

    • URL

      http://www.pharm.kyoto-u.ac.jp/seizo/publication.htm

    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] GPR54アゴニスト活性を有する化合物2006

    • Inventor(s)
      藤井 信孝 他
    • Industrial Property Rights Holder
      京都大学
    • Industrial Property Number
      2006-122305
    • Filing Date
      2006-04-26
    • Related Report
      2006 Annual Research Report
  • [Patent(Industrial Property Rights)] 抗FIV剤2006

    • Inventor(s)
      藤井 信孝 他
    • Industrial Property Rights Holder
      京都大学, 東京大学
    • Industrial Property Number
      2006-242428
    • Filing Date
      2006-09-07
    • Related Report
      2006 Annual Research Report
  • [Patent(Industrial Property Rights)] 抗HIV剤2006

    • Inventor(s)
      藤井 信孝 他
    • Industrial Property Rights Holder
      京都大学
    • Industrial Property Number
      2006-290241
    • Filing Date
      2006-10-25
    • Related Report
      2006 Annual Research Report
  • [Patent(Industrial Property Rights)] N36結合ペプチドの製造方法2006

    • Inventor(s)
      藤井 信孝 他
    • Industrial Property Rights Holder
      月桂冠株式会社
    • Industrial Property Number
      2006-204827
    • Filing Date
      2006-07-27
    • Related Report
      2006 Annual Research Report

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Published: 2006-04-01   Modified: 2018-03-28  

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