Development of Metabolomics Technology and Its Application to the Prediction of Novel Metabolic Pathways

• Project/Area Number: 18016028
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Keio University
• Principal Investigator: TOMITA Masaru Keio University, 環境情報学部, 教授 (60227626)
• Co-Investigator(Kenkyū-buntansha): NISHIOKA Takaaki 慶應義塾大学, 政策・メディア研究科, 教授 (80026559) ; SOGA Tomoyoshi 慶應義塾大学, 環境情報学部, 教授 (60338217) ; KANAI Akio 慶應義塾大学, 環境情報学部, 教授 (60260329)
• Project Period (FY): 2006 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥47,700,000 (Direct Cost: ¥47,700,000); Fiscal Year 2009: ¥12,100,000 (Direct Cost: ¥12,100,000); Fiscal Year 2008: ¥12,000,000 (Direct Cost: ¥12,000,000); Fiscal Year 2007: ¥11,900,000 (Direct Cost: ¥11,900,000); Fiscal Year 2006: ¥11,700,000 (Direct Cost: ¥11,700,000)
• Keywords: メタボローム解析 / バイオインフォマティクス / 質量分析 / 代謝流束解析 / ケモインフォマティクス / MassBank / pH制御合成法 / プロテオーム解析 / emPAI法 / システムバイオロジー / メタボローム / 質量分析計 / キャピラリー電気泳動-質量分析計 / E-Cell / 赤血球 / 解糖系 / 大腸菌 / エネルギー代謝 / 頑強性

Research Abstract

We have attained highly reliable identification and highly sensitive quantification in metabolomics based on capillary electrophoresis-mass spectrometry (CE-MS) by developing bioinformatics tools for high-throughput data analysis, flux analysis, modeling metabolism, and finding metabolic pathways. Usefulness of the tools developed were confirmed by their successful applications to the studies on integrative omics analysis of Escherichia coli mutant cells, metabolic pathway analyses using metabolic perturbations by photoperiod in Oryza sativa leaves, and molecular mechanism of non-oxidative phosphorylation energy production in cancer cells.

Research Products

• [Journal Article] Metabolite profiling reveals YihU as a novel hydroxybutyrate dehydrogenase for alternative succinic semialdehyde mtabolism in Eschericha coli (2009)
  • Author(s): Saito, その他6名
  • Journal Title: J. Biol. Chem. 284 Pages: 16442-51
  • Peer Reviewed
• [Journal Article] Quantitative metabolome profiling of colon and stomach cancer microenvironment by capillary electrophoresis time-of-flight mass spectrometry (2009)
  • Author(s): Hirayama, A., その他10名
  • Journal Title: Cancer Res 69 Pages: 4918-25
  • Peer Reviewed
• [Journal Article] Metabolomic Profiling of Anionic Metabolites by Capillary Electrophoresis Mass Spectrometry (2009)
  • Author(s): Soga, T., その他5名
  • Journal Title: Anal. Chem 81 Pages: 6165-74
  • Peer Reviewed
• [Journal Article] In silico modeling and metabolome analysis of long-stored erythrocytes to improve blood storage methods (2009)
  • Author(s): Nishino, T., Yachie, A.K., Hirayama. A., Soga, T., Suematsu, T., Tomita, M.
  • Journal Title: J. Biotech 144 Pages: 212-223
  • Peer Reviewed
• [Journal Article] Capillary electrophoresis mass spectrometry-based saliva metabolomics identified oral, breast and pancreatic cancer-specific profiles (2009)
  • Author(s): Sugimoto, M., Wong, D.T., Hirayama, A., Soga, T., Tomita, M.
  • Journal Title: Metabolomics 6 Pages: 78-95
  • Peer Reviewed
• [Journal Article] Differential Metabolomics Software for Capillary Electrophoresis-Mass Spectrometry Data Analysis (2009)
  • Author(s): Sugimoto, M., Hirayama, A., Ishikawa, T., Baran, R., Robert, M., Uehara, K., Soga, T., Tomita, M.
  • Journal Title: Metabolomics 6 Pages: 27-41
  • Peer Reviewed
• [Journal Article] Correlation between Sensory Evaluation Scores of Japanese Sakeand MetabolomeProfiles (2009)
  • Author(s): Sugimoto, M., Koseki, T., Hirayama, A., Abe, S., Sano, T., Tomita, M., Soga, T.
  • Journal Title: J. Agric. Food Chem 58 Pages: 374-383
  • Peer Reviewed
• [Journal Article] Tri-split tRNA: A transfer RNA made from three transcripts provides insight into the evolution of fragmented tRNAs in archaea" (2009)
  • Author(s): Fujishima, K.
  • Journal Title: Proc Natl Acad Sci USA. 106 Pages: 2683-2687
  • Peer Reviewed
• [Journal Article] Genome Projector: zoomable genome map with multiple views (2009)
  • Author(s): Arakawa, K.
  • Journal Title: BMC Bioinformatics 10 Pages: 31-31
  • Peer Reviewed
• [Journal Article] Correlation between Sensory Evaluation Scores of Japanese Sakeand Metabolome Profiles (2009)
  • Author(s): Sugimoto, M.
  • Journal Title: J.Agric.FoodChem 58 Pages: 374-383
  • Peer Reviewed
• [Journal Article] Differential Metabolomics Software for Capillary Electrophoresis-Mass Spectrometry Data Analysis (2009)
  • Author(s): Sugimoto, M.
  • Journal Title: Metabolomics [Epub ahead of print] 6 Pages: 27-41
  • Peer Reviewed
• [Journal Article] Capillaryelectrophoresis mass spectrometry-based saliva metabolomics identified oral, breast and pancreatic cancer-specific profiles (2009)
  • Author(s): Sugimoto, M.
  • Journal Title: Metabolomlcs [Epub ahead of print] 6 Pages: 78-95
  • Peer Reviewed
• [Journal Article] In silico modeling and metabolome analysis of long-stored erythrocytes to improve blood storage methods (2009)
  • Author(s): Nishino, T.
  • Journal Title: Journal of Biotechnology 144 Pages: 212-223
  • Peer Reviewed
• [Journal Article] Metabolomic Profiling of Anionic Metabolites by Capillary Electrophoresis Mass Spectrometry (2009)
  • Author(s): Soga, T.
  • Journal Title: Analytical Chemistry 81 Pages: 6165-6174
  • Peer Reviewed
• [Journal Article] Quantitative metabolome profiling of colon and stomach cancer microenvironment by capillary electrophoresis time-of-flight mass spectrometry (2009)
  • Author(s): Hirayama, A.
  • Journal Title: Cancer Res 69 Pages: 4918-4925
  • Peer Reviewed
• [Journal Article] Metabolite profiling reveals YihU as a novel hydroxybutyrate dehydrogenase for alternative succinic semialdehyde mtabolism in Eschericha coli (2009)
  • Author(s): Saito, N.
  • Journal Title: J.Biol.Chem. 284 Pages: 16442-16451
  • Peer Reviewed
• [Journal Article] Genome ProJector zoomable genome map with multiple views (2009)
  • Author(s): Arakawa, K
  • Journal Title: BMC Bioinformatics 10 Pages: 31-31
  • Peer Reviewed
• [Journal Article] Tri-split tRNA A transfer RNA made from three transcripts provides insight into the evolution of fragmented tRNAs in archaea (2009)
  • Author(s): FuJishima, K
  • Journal Title: Proc Natl Acad Sci USA 106 Pages: 2683-2687
  • Peer Reviewed
• [Journal Article] Automated Phosphoproteome Analysis for Cultured Cancer Cells by Two-Dimensional NanoLC-MS Using a Calcined Titania/C18 Biphasic Column (2008)
  • Author(s): Imami, K.
  • Journal Title: Innovations in Analytical Sciences 24 Pages: 161-161
  • Peer Reviewed
• [Journal Article] Depiction of metabolome changesin histidine-starved Escherichia coli by CE-TOFMS (2008)
  • Author(s): Ohashi, Y.
  • Journal Title: Mol. BioSyst 4 Pages: 135-147
  • Peer Reviewed
• [Journal Article] Large-scale phosphorylation mapping reveals the extent of tyrosine phosphorylation in Arabidopsis (2008)
  • Author(s): Sugiyama, N.
  • Journal Title: Mol Syst Biol. 4 Pages: 193-193
  • Peer Reviewed
• [Journal Article] Time-resolved metabolomics reveals metabolic modulation in rice foliage (2008)
  • Author(s): Sato, S.
  • Journal Title: BMC Systems Biology 2 Pages: 51-51
  • Peer Reviewed
• [Journal Article] Successive and Selective Release of Phosphorylated Peptides Captured by hydroxy Acid-Modified Metal Oxide Chromatography (2008)
  • Author(s): Kyono, Y.
  • Journal Title: J. Proteome Res Pages: 4585-4593
  • Peer Reviewed
• [Journal Article] Visualizing Complex Omics Information-Scientific Visualization for Genomics and Systems Biology (2008)
  • Author(s): Arakawa, K.
  • Journal Title: BIOforum Europe 6 Pages: 27-29
  • Peer Reviewed
• [Journal Article] Aligning LC Peaks by Converting Gradient Retention Times to Retention Index of Peptides in Proteomic Experiments (2008)
  • Author(s): Shinoda, K.
  • Journal Title: Bioinformatics 24 Pages: 1590-1595
  • Peer Reviewed
• [Journal Article] Depiction of metabolome changes in histidine-starved Esche richia coli by CE-TOFMS (2008)
  • Author(s): Ohashi Y, Hirayama A, Ishikawa T, Nakamura S, Shimizu K, Ueno Y, Tomita M and Soga T
  • Journal Title: Mol. BioSist 4 Pages: 135-147
  • Peer Reviewed
• [Journal Article] Aligning LC Peaks by Converting Gradient Retention Times to Retention Index of Peptides in Proteomic Experiments (2008)
  • Author(s): Shinoda K, Tomita M, Ishihama. Y.
  • Journal Title: Bioinformatics 24 Pages: 1590-1595
  • Peer Reviewed
• [Journal Article] Aligning LC Peaks by Converting Gradient Retention Times t o Retention Index of Peptides in Proteomic Experiments (2008)
  • Author(s): Shinoda, K
  • Journal Title: Bioinformatics 24 Pages: 1590-1595
  • Peer Reviewed
• [Journal Article] Visualizing Complex Omics Information-Scientific Visualiza tion for Genomics and Systems Biology (2008)
  • Author(s): Arakawa, K
  • Journal Title: BlOforum Europe 6 Pages: 27-29
  • Peer Reviewed
• [Journal Article] Successive and Selective Release of Phosphorylated Peptide s Captured by hydroxy Acid-Modified Metal Oxide Chromatography (2008)
  • Author(s): Kyono, Y
  • Journal Title: Journal of Proteome Research 7 Pages: 4585-4593
  • Peer Reviewed
• [Journal Article] Time-resolved metabolomics reveals metabolic modulation in rice foliage (2008)
  • Author(s): Sato, S
  • Journal Title: BMC Systems Biology 2 Pages: 51-51
  • Peer Reviewed
• [Journal Article] Large-scale phosphorylation mapping reveals the extent of tyrosine phosphorylation in Arabidopsis (2008)
  • Author(s): Sugiyama, N
  • Journal Title: Mol Syst Biol 4 Pages: 193-193
  • Peer Reviewed
• [Journal Article] Depiction of metabolome changes in histidine-starved Esche richia coli by CE-TOFMS (2008)
  • Author(s): Ohashi, Y
  • Journal Title: Mol BioSyst 4 Pages: 135-147
  • Peer Reviewed
• [Journal Article] Automated Phosphoproteome Analysis for Cultured Cancer Cel Is by Two-Dimensional NanoLC-MS Using a Calcined Titania/C18 Biphasic Column (2008)
  • Author(s): Imami, K
  • Journal Title: Innovations in Analytical. Sciences 24 Pages: 161-161
  • Peer Reviewed
• [Journal Article] トランスクリプトーム,プロテオーム,メタボローム,フラクソームの統合による大腸菌の代謝解明 (2008)
  • Author(s): 石井伸佳
  • Journal Title: 実験医学 26 Pages: 24-29
• [Journal Article] Multiple High- Throughput Analyses Monitor the Response of E. coli to Perturbations (2007)
  • Author(s): 石井伸佳, ほか28名
  • Journal Title: Science 316 Pages: 593-597
  • Peer Reviewed
• [Journal Article] Multiple High-Throughput Analyses Monitor the Response of E.coli to Perturbations. (2007)
  • Author(s): Ishii N, Nakahigashi K, Baba T, Robert M, Soga T, Kanai A, Hirasawa T, Naba M, Hirai K, Hoque A, Ho PY, Kakazu Y, Sugawara K, Igarashi S, Harada S, Masuda T, Sugiyama N, Togashi T, Hasegawa M, Takai Y, Yugi K, Arakawa K, Iwata N, Toya Y, Nakayama Y, Nishioka T, Shimizu K, Mori H, Tomita M
  • Journal Title: Science 10.112(DOI:10.1126/science.1132067)
  • Peer Reviewed
• [Journal Article] CheA-CheYpの親和性と大腸菌化学走性における順応誤差の解析 (2007)
  • Author(s): 松崎由理
  • Journal Title: 情報処理学会論文誌:数理モデル化と応用 48 Pages: 91-97
  • Peer Reviewed
• [Journal Article] システムバイオロジーのためのモデリング・シミュレーション環境 (2007)
  • Author(s): 櫻田剛史
  • Journal Title: 情報処理 48 Pages: 1089-1095
• [Journal Article] Multiple High-Throughput Analyses Monitor the Response of E. coli to Perturbations. (2007)
  • Author(s): 石井 伸佳
  • Journal Title: Science 10. 1126
• [Journal Article] Differential metabolomics reveals ophthalmic acid as an oxidative stress biomarker indicating hepatic glutathione consumption (2006)
  • Author(s): 曽我朋義, ほか10名
  • Journal Title: J. Biol. Chem 281(24) Pages: 16768-16776
  • Peer Reviewed
• [Journal Article] A metabolomics approach for enzyme discovery (2006)
  • Author(s): 斎藤菜摘, ほか7名
  • Journal Title: J Proteome Research 5(8) Pages: 1979-1987
  • Peer Reviewed
• [Journal Article] MathDAMP: a package for differential analysis of metabolite profiles (2006)
  • Author(s): Richard Baran, ほか7名
  • Journal Title: BMC Bioinformatics 7 Pages: 530-538
  • Peer Reviewed
• [Journal Article] Prediction of liquid chromatographic retention times of peptides generated by protease digestion of the Escherichia coli proteome using artificial neural networks (2006)
  • Author(s): 篠田幸作, ほか7名
  • Journal Title: J. Proteome Research 5(12) Pages: 3312-3317
  • Peer Reviewed
• [Journal Article] HybGFS: hybrid method for genome-fingerprint scanning. (2006)
  • Author(s): 篠田幸作, ほか6名
  • Journal Title: BMC Bioinformatics 7 Pages: 479-486
  • Peer Reviewed
• [Journal Article] Differential metabolomics reveals ophthalmic acid as an oxidative stress biomarker indicating hepatic glutathione consumption. (2006)
  • Author(s): Soga T, Baran R, Suematsu M, Ueno Y, Ikeda S, Sakurakawa T, Kakazu Y,Ishikawa T, Robert M, Nishioka T, Tomita M
  • Journal Title: The Journalofbiologicalchemistry 281(24) Pages: 16768-16776
  • Peer Reviewed
• [Journal Article] HybGFS : a hybrid method for genome-fingerprint scanning. (2006)
  • Author(s): 篠田 幸作
  • Journal Title: BMC Bioinformatics 7・479
• [Journal Article] Prediction of liquid chromatographic retention times of peptides generated by protease digestion of the Escherichia coli proteome using artificial neural networks (2006)
  • Author(s): 篠田 幸作
  • Journal Title: Journal of proteome research 15 (12) Pages: 3312-3317
• [Journal Article] MathDAMP : a package for differential analysis of metabolite profiles. (2006)
  • Author(s): Richard Baran
  • Journal Title: BMC Bioinformatics 7・530
• [Journal Article] A metabolomics approach for enzyme discovery (2006)
  • Author(s): 斎藤 菜摘
  • Journal Title: Journal of proteome research 5 (8) Pages: 1979-1987
• [Journal Article] Differential metabolomics reveals ophthalmic acid as an oxidative stress biomarker indicating hepatic glutathione consumption. (2006)
  • Author(s): 曽我 朋義
  • Journal Title: The Journal of biological chemistry 281 (24) Pages: 16768-16776
• [Presentation] Metabolomes and data-driven systems biology (2009)
  • Author(s): Tomita, M.
  • Organizer: The 10th International Conference on Systems Biology
  • Place of Presentation: San Francisco, USA.
  • Year and Date: 2009-09-03
• [Presentation] Metabolomes and data-driven systems biology (2009)
  • Author(s): Masaru Tomita
  • Organizer: The 10th International Conference on Systems Biology
  • Place of Presentation: San Francisco, U.S.A.
  • Year and Date: 2009-09-03
• [Presentation] Metabolomics and Systems Biology (2009)
  • Author(s): Tomita, M.
  • Organizer: Foundations OF Systems Biology In Engineering
  • Place of Presentation: Denver, USA.
  • Year and Date: 2009-08-10
• [Presentation] Metabolomics and Systems Biology (2009)
  • Author(s): Masaru Tomita
  • Organizer: Foundations OF Systems Biology In Engineering
  • Place of Presentation: Denver, U.S.A.
  • Year and Date: 2009-08-10
• [Presentation] E-Cell 3D: 3-dimensional visulization of cellular simulation results (2009)
  • Author(s): Nozomu Yachie
  • Organizer: ISMB/ECCB2007
  • Place of Presentation: Wien, Austria
  • Year and Date: 2009-07-26
• [Presentation] eXpanda: an integrated platform for network analysis and visualization (2009)
  • Author(s): Hiroyuki Nakamura
  • Organizer: ISMB/ECCB2007
  • Place of Presentation: Wien, Austria
  • Year and Date: 2009-07-26
• [Presentation] MEGU: Pathway mapping web-service based on KEGG and SVG (2009)
  • Author(s): Kazuharu Arakawa
  • Organizer: ISMB/ECCB2007
  • Place of Presentation: Wien, Austria
  • Year and Date: 2009-07-26
• [Presentation] Metabolome analysis and systems biology, Albany 2009 (2009)
  • Author(s): Tomita, M.
  • Organizer: The 16th Conversation
  • Place of Presentation: Albany, USA.
  • Year and Date: 2009-06-18
• [Presentation] Metabolome analysis and systems biology (2009)
  • Author(s): Masaru Tomita
  • Organizer: Albany 2009, The 16th Conversation
  • Place of Presentation: Albany,U.S.A
  • Year and Date: 2009-06-18
• [Presentation] High-throughput multi-omics systems biology and its applications (2008)
  • Author(s): Tomita, M.
  • Organizer: International Launch Conference Frontiers in Multi-Scale Systems Biology
  • Place of Presentation: Atlanta, USA.
  • Year and Date: 2008-10-19
• [Presentation] High-throughput multi-omics systems biology and its applic ations (2008)
  • Author(s): Masaru Tomita
  • Organizer: International Launch Conference Frontiers in Multi-Scale Systems Biology
  • Place of Presentation: Georgian Terrace Hote I, Atlanta, U.S.A.
  • Year and Date: 2008-10-19
• [Presentation] Metabolome analysis and systems biology (2008)
  • Author(s): Tomita, M.
  • Organizer: The 13thInternational Biotechnology Symposium (IBS) and Exhibition
  • Place of Presentation: Dalian World Expo CenterDalian, China
  • Year and Date: 2008-10-16
• [Presentation] Metabolome analysis and systems biology (2008)
  • Author(s): Masaru Tomita
  • Organizer: The 13th International Biotechnology Symposium (IBS) and Exhibition
  • Place of Presentation: the Dalian World Expo CenterDalian, China
  • Year and Date: 2008-10-16
• [Presentation] Metabolomics and Systems Biology (2008)
  • Author(s): Tomita, M.
  • Organizer: The Second q-bio Conference on Cellular Information Processing
  • Place of Presentation: Santa Fe, U.S.A.
  • Year and Date: 2008-08-08
• [Presentation] Metabolomics and Systems Biology (2008)
  • Author(s): Masaru Tomita
  • Organizer: The Second q-bio Conference on Cellular In formation Processing
  • Place of Presentation: Santa Fe, U.S.A
  • Year and Date: 2008-08-08
• [Presentation] Multi-omics analysis and integrative Systems Biology (2008)
  • Author(s): 冨田勝
  • Organizer: Genomes to Systems Conference
  • Place of Presentation: Manchester, UK
  • Year and Date: 2008-03-19
• [Presentation] Multi-omics analysis and integrative Systems Biology (2008)
  • Author(s): 冨田 勝
  • Organizer: Genomes to Systems conference 2008
  • Place of Presentation: Manchester, UK
  • Year and Date: 2008-03-19
• [Presentation] Metabolomics and its applications to integrative systems biology (2008)
  • Author(s): 冨田勝
  • Organizer: The 10th International Conference on Molecular Systems Biology
  • Place of Presentation: Manila, Philippines
  • Year and Date: 2008-02-27
• [Presentation] Metabolomics and its applications to integrative systems biology (2008)
  • Author(s): 冨田 勝
  • Organizer: The 10th International Conference on Molecular Systems Biology (ICMSB 2008)
  • Place of Presentation: Manila, Philippines
  • Year and Date: 2008-02-27
• [Presentation] メタボローム解析によるがん診断 (2008)
  • Author(s): 冨田 勝
  • Organizer: 静岡がん会議2007
  • Place of Presentation: 静岡
  • Year and Date: 2008-02-16
• [Presentation] メタボローム解析と統合システムバイオロジー (2007)
  • Author(s): 冨田 勝
  • Organizer: 第30回日本分子生物学会念会・第80回日本生化学会大会 合同大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-13
• [Presentation] 低酸素に応答したヒト赤血球代謝における解糖系活性化の役割と機構の解析:コンピュータシミュレーションによる予測とメタボロームによる実証 (2007)
  • Author(s): 木下綾子,塚田孝祐,曽我朋義,菱木貴子,西野泰子,冨田勝,末松誠
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-12-11
• [Presentation] 網羅的ハイスループット解析による大腸菌の遺伝的・環境的変動への応答の観測 (2007)
  • Author(s): 石井 伸佳
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-12-11
• [Presentation] MEGU: KEGG に基づいたオミクスデータのパスウェイ可視化ウェブアブリケーシヨン (2007)
  • Author(s): 河野 暢明
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-12-11
• [Presentation] インタラクトーム統合解析プラットフォームeXpanda (2007)
  • Author(s): 中村 浩之
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-12-11
• [Presentation] E-Cell 3D: 細胞シミュレーションデータの三次元可視化 (2007)
  • Author(s): 荒川 和晴
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-12-11
• [Presentation] 哺乳類時計遺伝子発振ネットワークの定量的モデリングとシミュレーション (2007)
  • Author(s): 小川 雪乃
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-12-11
• [Presentation] 低酸素に応答したヒト赤血球代謝における解糖系活性化の役割と機構の解析:コンピュータシミュレーションによる予測とメタボロームによる実証 (2007)
  • Author(s): 木下 綾子
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-12-11
• [Presentation] ヒト赤血球代謝シミュレーションモデルを用いた低温保存血液における赤血球代謝動態の予測と解析 (2007)
  • Author(s): 西野 泰子
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-12-11
• [Presentation] 単細胞モデルに基づく多細胞組織モデル:肝小葉における組織内遺伝子発現調節のシミュレーション (2007)
  • Author(s): 内藤 泰宏
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-12-11
• [Presentation] メタボロームプロフアイリングを利用した酵素機能解析 (2007)
  • Author(s): 斎藤 菜摘
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-12-11
• [Presentation] 糸状仮足の数理モデルを用いた神経成長円錐の旋回シミュレーション (2007)
  • Author(s): 藤本 顕士
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-12-11
• [Presentation] Metabolome Science and Systems Biology (2007)
  • Author(s): 冨田勝
  • Organizer: The 7th International Workshop on Advanced Genomics
  • Place of Presentation: Tokyo, JAPAN
  • Year and Date: 2007-11-27
• [Presentation] メタボロームとシステムズバイオロジーの医療への応用 (2007)
  • Author(s): 冨田 勝
  • Organizer: 第37回日本免疫学会総会・学術集会
  • Place of Presentation: 品川
  • Year and Date: 2007-11-20
• [Presentation] メタボローム科学の発展とシステムバイオロジー (2007)
  • Author(s): 冨田 勝
  • Organizer: KAST 財団法人神奈川科学技術アカデミー 平成19年度教育講座
  • Place of Presentation: 溝の口
  • Year and Date: 2007-11-15
• [Presentation] Multi-omics data-driven systems biology, International Society for Computational Biology (2007)
  • Author(s): 冨田勝
  • Organizer: Special Interest Group on Biosimulation
  • Place of Presentation: Long Beach, USA
  • Year and Date: 2007-10-05
• [Presentation] Multi-omics data-driven systems biology (2007)
  • Author(s): 冨田 勝
  • Organizer: International Society for Computational Biology, Special Interest Group on Biosimulation
  • Place of Presentation: Long Beach, USA
  • Year and Date: 2007-10-05
• [Presentation] メタボローム解析とシステムバイオロジーの医療への応用 (2007)
  • Author(s): 冨田 勝
  • Organizer: 第26回消化器病態生理勉強会
  • Place of Presentation: 新宿
  • Year and Date: 2007-08-04
• [Presentation] 網羅的ハイスループット解析によって示唆される大腸菌の遺伝的・環境的変動に対する頑強性 (2007)
  • Author(s): 戸谷 吉博
  • Organizer: 第4回21世紀大腸菌研究会
  • Place of Presentation: 静岡国民年金健康センター藤枝エミナース
  • Year and Date: 2007-07-17
• [Presentation] Large-scale multi-omics analyses for E. coli systems biology (2007)
  • Author(s): 冨田勝
  • Organizer: 3rd Metabolomics Society Annual Conference
  • Place of Presentation: Manchester, UK
  • Year and Date: 2007-06-12
• [Presentation] Large・scale multi-omics analyses for E. coli systems biology (2007)
  • Author(s): 冨田 勝
  • Organizer: 3rd Metabolomics Society Annual Conference
  • Place of Presentation: Manchester, UK
  • Year and Date: 2007-06-12
• [Presentation] Multi-omics analysis and data-driven systems biology, E cell (2007)
  • Author(s): 冨田勝
  • Organizer: The Steering Committee of the 2nd Annual Summit on Systems Biology
  • Place of Presentation: Richmond, USA
  • Year and Date: 2007-06-05
• [Presentation] Multi-omics analysis and data-driven systems biology, E cell (2007)
  • Author(s): 冨田 勝
  • Organizer: The Steering Committee of the 2nd Annual Summit on Systems Biology
  • Place of Presentation: Richmond,USA
  • Year and Date: 2007-06-05
• [Presentation] Metabolome analysis and cell simulation (2007)
  • Author(s): 冨田勝
  • Organizer: Systems Biology Workshop-2007
  • Place of Presentation: Melbourne, Australia.
  • Year and Date: 2007-05-29
• [Presentation] Metabolome analysis and cell simulation (2007)
  • Author(s): 冨田 勝
  • Organizer: Systems Biology Workshop - 2007
  • Place of Presentation: Melbourne, Australia
  • Year and Date: 2007-05-29
• [Presentation] MEGU: Pathway mapping web-service based on KEGG and SVG (2007)
  • Author(s): Arakawa, K.
  • Organizer: ISMB/ECCB2007
  • Place of Presentation: Wien, Austria.
• [Presentation] eXpanda: an integrated platform for network analysis and visualization (2007)
  • Author(s): Nakamura, H.
  • Organizer: ISMB/ECCB2007
  • Place of Presentation: Wien, Austria.
• [Presentation] E-Cell 3D: 3-dimensional visulization of cellular simulation results (2007)
  • Author(s): Yachie, N.
  • Organizer: ISMB/ECCB2007
  • Place of Presentation: Wien, Austria
• [Book] E coli metabolomics; capturing the complexity of a "simple" model(Metabolomics-A Powerful Tool in Systems Biology-, vol. 18) (2007)
  • Author(s): Martin, R
• [Book] メタボロミクスの医学への応用 (2007)
  • Author(s): 曽我朋義
  • Publisher: 最新医学社
• [Book] E coli metabolomics; capturing the complexity of a "simple" model (2007)
  • Author(s): Martin, R
  • Publisher: Metabolomics-A Powerful Tool in Systems Biology-(vol. 18)