System-level Understanding of Intercellular Interactions
Project/Area Number |
18016031
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Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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Allocation Type | Single-year Grants |
Review Section |
Biological Sciences
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Research Institution | The Institute of Physical and Chemical Research |
Principal Investigator |
UEDA Hiroki (UEDA,) The Institute of Physical and Chemical Research, システムバイオロジー研究チーム, チームリーダー (20373277)
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Co-Investigator(Kenkyū-buntansha) |
UKAI Hideki 独立行政法人理化学研究所, システムバイオロジー研究チーム, 研究員 (70391878)
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Project Period (FY) |
2006 – 2009
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Project Status |
Completed (Fiscal Year 2009)
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Budget Amount *help |
¥64,200,000 (Direct Cost: ¥64,200,000)
Fiscal Year 2009: ¥13,400,000 (Direct Cost: ¥13,400,000)
Fiscal Year 2008: ¥13,300,000 (Direct Cost: ¥13,300,000)
Fiscal Year 2007: ¥13,200,000 (Direct Cost: ¥13,200,000)
Fiscal Year 2006: ¥24,300,000 (Direct Cost: ¥24,300,000)
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Keywords | システムバイオロジー / 再構成 / 体内時計 / 細胞間情報伝達 / 一細胞イメージング / シンギュラリティー / 光制御 / 位相制御 / 哺乳類 / 細胞間相互作用 / 転写制御 / 位相 / シンギュラリティー現象 / 光による定量的な制御 / メラノプシン / 脱同調 / バイオイメージング / バイオインフォマティクス / 理論生物学 |
Research Abstract |
Central clock (the suprachiasmatic nucleus ; SCN) of mammal produces robust oscillation even in the presence of internal noise without referring to external time cues. Ueda et al proposed stochastic model of intercellular coupling mechanism, and theoretically indicated that the robustness of central clock is caused by intercellular interaction of clock cells (J.Theor.Biol.(2002) 216, 501-512). In this project, we tried to physically simulate the model by synthesis of intercellular interaction mechanism in peripheral clock cells in order to proof the model.
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Report
(6 results)
Research Products
(63 results)
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[Journal Article] Melanopsin-dependent photo-perturbation reveals desynchronization underlying the singularity of mammalian circadian clocks2007
Author(s)
Ukai, H., Kobayashi, T.J., Nagano, M., Masumoto, K., Sujino, M., Kondo, T., Yagita K., Shigeyoshi, Y., Ueda, H.R.
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Journal Title
Nature Cell Biology 9
Pages: 1327-1334
Related Report
Peer Reviewed
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[Journal Article] A functional genomics strategy reveals clockwork orange as a transcriptional regulator in the Drosophila circadian clock.2007
Author(s)
Matsumoto, A., Ukai-Tadenuma, M., Yamada, R.G., Houl, J., Uno, D.K., Kasukawa, T., Dauwalder, B., Itoh, T., Takahashi, K., Ueda, R., Hardin, P., Tanimura, T, * Ueda, H.R.
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Journal Title
Genes & Development 21(13)
Pages: 1687-700
Related Report
Peer Reviewed
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[Journal Article] Melanopsin-dependent photo-perturbation reveals desynchronization underlying the singularity of mammalian circadian clocks2007
Author(s)
Ukai, H., Kobayashi, T.J., Nagano, M., Masumoto, K., Sujino, M., Kondo, T., Yagita K., Shigeyoshi, Y. and Ueda, H.R.
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Journal Title
Nature Cell Biology 9
Pages: 1327-1334
Related Report
Peer Reviewed
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[Journal Article] Feedback repression is required for mammalian circadian clock function2006
Author(s)
Sato, T.K., Yamada, R.G., Ukai, H., Baggs, J.E., Miraglia, L.J., Kobayashi, T.J., Welsh, D.K., Kay, S.A., Ueda, H.R. *, Hogenesch, J.B.
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Journal Title
Nature Genetics 38
Pages: 312-319
Related Report
Peer Reviewed
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[Journal Article] Feedback repression is required for mammalian circadian clock function2006
Author(s)
Sato, T.K., Yamada, R.G., Ukai, H., Baggs, J.E., Miraglia, L.J., Kobayashi, T.J., Welsh, D.K., Kay, S.A., Ueda, H.R. and Hogenesch, J.B
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Journal Title
Nature Genetics 38
Pages: 312-319
Related Report
Peer Reviewed
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[Journal Article] System-level identification of transcriptional circuits underlying mammalian circadian clocks.2005
Author(s)
Ueda, H.R., Hayashi, S., Chen, W.B., Sano, M., Machida, M., Shigeyoshi, Y., Iino, M., Hashimoto, S.
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Journal Title
Nature Genetics 37(2)
Pages: 187-192
Related Report
Peer Reviewed
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[Presentation] 中枢時計を創る2009
Author(s)
鵜飼英樹
Organizer
細胞を創る研究会
Place of Presentation
東京大学医学部鉄門記念講堂(東京)
Year and Date
2009-10-02
Related Report
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[Presentation] 光と体内時計2009
Author(s)
Ueda, H. R
Organizer
太陽紫外線防御研究会
Place of Presentation
メルパルク京都(京都)
Year and Date
2009-07-27
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[Presentation] 中枢時計を創る2007
Author(s)
鵜飼英樹
Organizer
細胞を創る」研究会0. 0
Place of Presentation
日本科学未来館(東京)
Year and Date
2007-11-25
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[Book] 生体の科学2008
Author(s)
Ukai, H., Kobayashi, TJ., Ueda, HR.
Total Pages
2
Publisher
医学書院
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[Book]
Author(s)
上田泰己
Publisher
時間生物学会
Related Report