Research Project
Grant-in-Aid for Scientific Research on Priority Areas
Central clock (the suprachiasmatic nucleus ; SCN) of mammal produces robust oscillation even in the presence of internal noise without referring to external time cues. Ueda et al proposed stochastic model of intercellular coupling mechanism, and theoretically indicated that the robustness of central clock is caused by intercellular interaction of clock cells (J.Theor.Biol.(2002) 216, 501-512). In this project, we tried to physically simulate the model by synthesis of intercellular interaction mechanism in peripheral clock cells in order to proof the model.
All 2010 2009 2008 2007 2006 2005 Other
All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (45 results) Book (8 results)
Nature Cell Biology 10
Pages: 1154-1163
Nature Cell Biology 9
Pages: 1327-1334
Genes & Development 21(13)
Pages: 1687-700
Nature Genetics 38
Pages: 312-319
Nature Genetics 37(2)
Pages: 187-192