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皮質間および皮質下構造ネットワークと高次脳機能

Research Project

Project/Area Number 18020014
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionKyoto University

Principal Investigator

福山 秀直  Kyoto University, 医学研究科, 教授 (90181297)

Co-Investigator(Kenkyū-buntansha) 長峯 隆  京都大学, 医学研究科, 准教授 (10231490)
池田 昭夫  京都大学, 医学研究科, 准教授 (90212761)
三國 信啓  京都大学, 医学研究科, 助教 (60314217)
松本 理器  京都大学, 医学研究科, 助教 (00378754)
澤本 伸克  京都大学, 医学研究科, 助教 (90397547)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥6,700,000 (Direct Cost: ¥6,700,000)
Fiscal Year 2007: ¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2006: ¥3,200,000 (Direct Cost: ¥3,200,000)
Keywords神経科学 / 磁気記録 / 脳・神経 / 脳神経疾患 / 言語 / 皮質間ネットワーク / 硬膜下電極 / 皮質誘発電位 / 拡散強調画像 / tractorahy / 側頭葉底面言語野 / ウェルニッケ野
Research Abstract

【背景】脳機能画像法を利用した大脳皮質機能マッピングは、Roy and Sherringtonが提唱したneurovascular couplingが成立することを前提としている。すなわち、神経活動に伴って二次的に血流カミ増加することを前提に、神経活動自体ではなく血流変化を測定している。しかし、このneurovascular couplingが常に正しい前提として保証されているとは言い難い。このような背景から我々は、拡散強調画像による機能的磁気共鳴画像法(DfMRI)を用いて、神経細胞の活動に直結する変化、具体的には神経活動に伴う細胞内の水の拡散運動の変化を、生体内の複雑な環境のままで推定する方法を開発してきた。【目的】今回我々は、DfMRIと、神経細胞の電気活動を評価できる脳磁図(MEG)とを複合的に用いて、DfMRI信号の生理的意義を明らかにするための基礎的研究を行った。
【方法】健常被験者2名を対象として、チェッカーボード図形を反転させる視覚刺激を与えてDfMRI、Blood Oxygen Level Dependent(BOLD)によるfMRIと、MEGの測定を行い、それらの空間分布と経時変化との相違を比較した。【結果】DfMRI、BOLDによるfMRI、MEG、それぞれの手法で、視覚刺激に反応する脳部位が同定できた。それらの空間分布と経時変化の相違を比較したところ、今回対象とした被験者では、三者の関係に一定の傾向を見出すことはできず、DfMRIの方がBOLDによるfMRIに比べて、神経細胞の活動をより正確に反映することを示すことはできなかった。【考察】今後さらに被験者数を増やすことで、DfMRIが細胞内の水の拡散運動の変化に伴う信号変化を反映し、直接神経細胞の活動を捉えているという仮説が確認できることが期待される。

Report

(2 results)
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (39 results)

All 2007 2006

All Journal Article (29 results) (of which Peer Reviewed: 17 results) Presentation (8 results) Book (2 results)

  • [Journal Article] Functional coupling of human prefrontal and premotor areas during cognitive manipulation2007

    • Author(s)
      Abe, M., et. al.
    • Journal Title

      J Neurosci 27

      Pages: 3429-38

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gliomatosis cerebri presenting as a parkinsonian syndrome2007

    • Author(s)
      Asada, T., et. al.
    • Journal Title

      J Neuroimaging 17

      Pages: 269-71

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Subregions of human parietal cortex selectively encoding object orientation2007

    • Author(s)
      Aso, T., et. al.
    • Journal Title

      Neurosci Lett 415

      Pages: 225-30

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fractional anisotropy and mean diffusivity: comparison between 3.0-T and 1.5-T diffusion tensor imaging with parallel imaging using hitogram and region of interest analysis2007

    • Author(s)
      Fushimi, Y., et. al.
    • Journal Title

      NMR Biomed 20

      Pages: 743-8

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gray matter-white matter contrast on spin-echo T1-weighted images at 3 T and 1.5 T: a quantitative comparison study2007

    • Author(s)
      Fushimi, Y., et. al.
    • Journal Title

      Eur Radiol 17

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of vascular parkinsonism with impaired neuronal integrity in the striatum2007

    • Author(s)
      Ihara, M., et. al.
    • Journal Title

      J Neural Transm 114

      Pages: 577-84

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Concurrence of non-myasthenic symptoms with myasthenia gravis2007

    • Author(s)
      Iseki, K., et. al.
    • Journal Title

      Neurol Sci 28

      Pages: 114-5

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical impact of integrated functional neuronavigation and subcortical electrical stimulation to preserve motor function during resection of brain tumors2007

    • Author(s)
      Mikuni, M., et. al.
    • Journal Title

      J Neurosurg 106

      Pages: 593-8

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical significance of preoperative fibre-tracking to preserve the affected pyramidal tracts during resection of brain tumours in patients with preoperative motor weakness2007

    • Author(s)
      Mikuni, M., et. al.
    • Journal Title

      J Neurol Neurosurg Psychiatry 78

      Pages: 716-21

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison between motor evoked potential recording and fibertracking for estimating pyramidal tracts near brain tumors2007

    • Author(s)
      Mikuni, M., et. al.
    • Journal Title

      J Neurosurg 106

      Pages: 128-33

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fibers from the dorsal premotor cortex elicit motor-evoked potential in a cortical dysplasia2007

    • Author(s)
      Mikuni, M., et. al.
    • Journal Title

      Neuroimage 34

      Pages: 12-18

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantification of nicotinic acetylcholine receptors in Parkinson' s disease with (123) I-5IA SPECT2007

    • Author(s)
      Oishi, N., et. al.
    • Journal Title

      J Neurol Sci 256

      Pages: 52-60

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neural correlates of regional EEG power change.2007

    • Author(s)
      Oishi, N., et. al.
    • Journal Title

      Neuroimage 36

      Pages: 1301-12

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diffusion tensor fiber tractography for arteriovenous malformations: quantitative analyses to evaluate the corticospinal trac2007

    • Author(s)
      Okada, T., et. al.
    • Journal Title

      AJNR Am J Neuroradiol 28

      Pages: 1107-13

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cognitive slowing in Parkinson disease is accompanied by hypofunctioning of the striatum2007

    • Author(s)
      Sawamoto, N., et. al.
    • Journal Title

      Neuruology 68

      Pages: 1062-8

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Use of magnetoencephalography in the presurgical evaluation2007

    • Author(s)
      Shibasaki, H., et. al.
    • Journal Title

      Clin Neurophysiol 118

      Pages: 1438-48

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heterospecific and conspecific social cognition in the anterior cingulate cortex2007

    • Author(s)
      Shinozaki, J., et. al.
    • Journal Title

      Neuroreport 18

      Pages: 993-7

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fibers from the dorsal premotor cortex elicit motorevoked potential in a cortical dysplasia.2007

    • Author(s)
      Mikuni, N. et al.
    • Journal Title

      Neuroimage 34

      Pages: 12-18

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Comparison between motor evoked potential recording and fiber tracking for estimating pyramidal tracts near brain2007

    • Author(s)
      Mikuni, N. et al.
    • Journal Title

      J Neurosurg 106

      Pages: 128-133

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Clinical significance of preoperative fiber-tracking to preserve the affected pyramidal tracts during the2007

    • Author(s)
      Mikuni, N. et al.
    • Journal Title

      J Neurol Neurosurg Psychiatry (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Subregions of human parietal cortex selectively encoding object orientation.2007

    • Author(s)
      Aso, T.et al.
    • Journal Title

      Neurosci Lett 415

      Pages: 225-230

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Transient functional suppression and facilitation of Japanese ideogram writing induced by repetitive2006

    • Author(s)
      Ueki, Y.et al.
    • Journal Title

      J Neurosci 26

      Pages: 8523-8530

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Altered plasticity of the human motor cortex in Parkinson's disease.2006

    • Author(s)
      Ueki, Y. et al.
    • Journal Title

      Ann Neurol 59

      Pages: 60-71

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Prefrontal hypofunction in patients with intractable mesial temporal lobe epilepsy.2006

    • Author(s)
      Takaya, S.et al.
    • Journal Title

      Neurology 67

      Pages: 1674-1676

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Evidence for a wide distribution of negative motor areas in the perirolandic cortex.2006

    • Author(s)
      Mikuni, N.et al.
    • Journal Title

      Clin Neurophysiol 117

      Pages: 33-40

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Subtemporal hippocampectomy preserving the basal temporal language area for intractable mesial temporal lobe2006

    • Author(s)
      Mikuni, N.et al.
    • Journal Title

      Epilepsia 47

      Pages: 1347-1353

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A step-by-step resection guided by electrocorticography for nonmalignant brain tumors associated with long-term2006

    • Author(s)
      Mikuni, N.et al.
    • Journal Title

      Epilepsy Behav 8

      Pages: 560-564

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Direct and fast detection of neuronal activation in the human brain with diffusion MRI.2006

    • Author(s)
      Le Bihan, D et al.
    • Journal Title

      Proc Natl Acad Sci U S A 103

      Pages: 8263-8268

    • Related Report
      2006 Annual Research Report
  • [Journal Article] "Burst and slow complexes" in nonconvulsive epileptic status.2006

    • Author(s)
      Ikeda, A.et al.
    • Journal Title

      Epileptic Disord 8

      Pages: 61-64

    • Related Report
      2006 Annual Research Report
  • [Presentation] 局限性皮質異形成のてんかん焦点における発作起始前後の皮質興奮性の変容2007

    • Author(s)
      松本 理器ほか
    • Organizer
      第41回日本てんかん学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2007-11-01
    • Related Report
      2007 Annual Research Report
  • [Presentation] てんかん外科の基礎と応用:てんかん外科における硬膜下電極2007

    • Author(s)
      三國 信啓
    • Organizer
      第27回日本脳神経外科コングレス総会
    • Place of Presentation
      仙台
    • Year and Date
      2007-05-20
    • Related Report
      2007 Annual Research Report
  • [Presentation] てんかんの外科:適応と再診の治療2007

    • Author(s)
      池田 昭夫
    • Organizer
      第48回日本神経学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2007-05-18
    • Related Report
      2007 Annual Research Report
  • [Presentation] ヒトの補足運動野機能の臨床的意義2007

    • Author(s)
      池田 昭夫
    • Organizer
      第48回日本神経学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2007-05-16
    • Related Report
      2007 Annual Research Report
  • [Presentation] 非侵襲的脳機能面像法による脳機能診断2007

    • Author(s)
      福山 秀直
    • Organizer
      第104回日本内科学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2007-04-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] Uncommon seizures and unusual seizure manifestations2007

    • Author(s)
      工keda, A.
    • Organizer
      27th International Epilepsy Congres
    • Place of Presentation
      Singapore
    • Related Report
      2007 Annual Research Report
  • [Presentation] Sensorimotor Cortex S-05-1 Movement related changes of rhythmic and slow activities recealed by2007

    • Author(s)
      Nagamine, T., et. al.
    • Organizer
      First Conference of Internatinoal Society for the Advancement of Clinical
    • Place of Presentation
      Miyagi, Japan
    • Related Report
      2007 Annual Research Report
  • [Presentation] MRI and neurophysiological techniques combination-recent advances-2007

    • Author(s)
      Fukuyama, H.
    • Organizer
      International Seminar Scientific Program
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2007 Annual Research Report
  • [Book] Textbook of epilepsy surgery(Luders HO(eds))2007

    • Author(s)
      Ikeda A.et al.
    • Publisher
      Taylor and Francis Book Ltd ; London(in press)
    • Related Report
      2006 Annual Research Report
  • [Book] Textbook of Epilepsy Surgery(Lu ders HO, Najm I, Bingaman W, eds.)2007

    • Author(s)
      Matsumoto R.et al.
    • Publisher
      Taylor & Francis Books Ltd, Abingdon(in press)
    • Related Report
      2006 Annual Research Report

URL: 

Published: 2006-04-01   Modified: 2018-03-28  

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