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ヒトの感情認知と感情生成の臨床神経心理学的研究

Research Project

Project/Area Number 18020027
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionShowa University

Principal Investigator

河村 満  Showa University, 医学部, 教授 (20161375)

Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥6,800,000 (Direct Cost: ¥6,800,000)
Fiscal Year 2007: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2006: ¥3,800,000 (Direct Cost: ¥3,800,000)
Keywords情動 / 扁桃体 / パーキンソン病 / 感情 / ドーパミン / レム睡眠行動障害 / 片頭痛 / 光過敏性 / 快・不快
Research Abstract

我々はこれまで継続して、神経・精神病理や加齢が感情の認知・生成・制御に及ぼす影響を検討してきている。扁桃体損傷患者(菅・石原・河村ら, 2003)、うつ病患者(Kan, Kawamura, et. al., 2004)、健常高齢者(鈴木・星野・河村, 2005)など対象は多岐にわたるが、臨床的応用を視野に入れ、高頻度疾患であるパーキンソン病患者の研究をとくに精力的に進めてきた。平成19年度の検討では意思決定および表情認知と関連した情動処理の問題について検討を行った。感情制御の問題として意思決定を検討した研究では、パーキンソン病患者がギャンブルを模した意思決定課題(以下、ギャンブル課題)において衝動の制御が障害されていることを確認し、ギャンブル課題における意思決定の問題は情動反応の低下と関連していることを示した。また、この結果が扁桃体損傷例の結果と類似していることを指摘した(Kobayakawa, Kawamura, et. al., in press)。感情生成の検討としては、不快嗅覚刺激に伴う事象関連電位を記録し、双極子追跡法によって発生源を検討することで、パーキンソン病患者では扁桃体を中心とした感情生成の脳内機構の機能が低下していることを示した(Masaoka, Kawamura, et. al., 2007)。また、黒質線条体系に限局的な病巣をもつ若年性パーキンソン病患者と、中脳皮質系にも影響がみられるとされる孤発性パーキンソン病患者との比較から、感情認知と扁桃体の密接な関連性が示唆された(Yoshimura, Kawamura, et. al., in press)。以上の我々の検討からは、パーキンソン病でみられた感情機能の多様な問題が扁桃体の機能低下と関連していることが示唆された。

Report

(2 results)
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (26 results)

All 2007 2006 Other

All Journal Article (13 results) (of which Peer Reviewed: 5 results) Presentation (11 results) Book (2 results)

  • [Journal Article] Relatively spared mesocorticolimbic dopaminergic system in juvenile parkinsonism.2007

    • Author(s)
      Yoshimura, N.・Yokochi, M.・Kan, Y.・Koyama, S.・Kawamura, M.
    • Journal Title

      Parkinsonism Relat. Disord. 13(8)

      Pages: 483-8

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Social cognitive impairment in Parkinson's Disease.2007

    • Author(s)
      Kawamura, M.・Koyama, S.
    • Journal Title

      J. Neurol. 254

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Impaired perception of facial expression, color, and smell as early ymptoms of Parkinson's dLsease.2007

    • Author(s)
      Kawamura, M.・Koyama, S.
    • Journal Title

      CNS Drugs 21

      Pages: 33-38

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 画像処理技術と心理物理学を用いた大脳皮質性色覚障害の評価.2007

    • Author(s)
      小山慎一、毛束真知子、日比野治雄、富満弘之、河村満.
    • Journal Title

      神経心理学 23

      Pages: 132-138

    • NAID

      10029840332

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impairment of odor recognition in Parkinson' s disease caused by weak activations of the orbitofrontal cortex2007

    • Author(s)
      Masaoka, Yoshimura, Inoue, Kawamura, Homma
    • Journal Title

      Neuroscience Letter 412(1)

      Pages: 45-50

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Decline or improvement? Age-related differences in facial expression recognition.2007

    • Author(s)
      Suzuki, Hoshino, Shigemasu, Kawamura
    • Journal Title

      Biological Psychology 74(1)

      Pages: 75-84

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Decision making in Parkinson's disease: Analysis of behavioral and physiological patterns in the Iowa gambling task

    • Author(s)
      Kobayakawa, M.・Koyama, S.・Mimura, M.・Kawamura, M.
    • Journal Title

      Mov. Disord. (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Respiratory responses to olfactory stimuli in Parkinson's disease.

    • Author(s)
      Masaoka, Y.・Satoh, H.・Kawamura, M.・Homma, I.
    • Journal Title

      Respiration Physiology and Neurobiology (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dementia and painting in patients from different cultural backgrounds.

    • Author(s)
      Midorikawa, A.・Fukutake, T.・Kawamura, M.
    • Journal Title

      Eur. Neurol. (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relatively spared mesocorticolimbic dopaminergic system in juvenile parkinsonism

    • Author(s)
      Yoshimura, Yokochi, Kan, Koyama, Kawamura
    • Journal Title

      Parkinsonism & Related Disorders (In press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Decreased myocardial ^<123>I-MIBG uptake and impaired facial expression recognition in a patient with REM sleep behavior disorder

    • Author(s)
      Koyama, Tachibana, Masaoka, Homma, Kawamura
    • Journal Title

      Movement Disorders (In press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Writing errors and anosognosia in amyotrophic lateral sclerosis with dementia

    • Author(s)
      Ichikawa, Koyama, Ohno, Ishihara, Nagumo, Kawamura
    • Journal Title

      Behavioural Neurology (In press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Persistent visual aura following catheter ablation in a patient with WPW syndrome

    • Author(s)
      Koyama, Kawamura
    • Journal Title

      Behavioural Neurology (In press)

    • Related Report
      2006 Annual Research Report
  • [Presentation] Social cognition and decision-making: cross-talk between neuropsychologists and neuroscientists.2007

    • Author(s)
      Kawamura, M.・Sakagami, M.・Bossaerts, P.・Kim, H.・Mimura, M.・Suzuki, A.・Koyama, S.
    • Organizer
      Neuro2007
    • Place of Presentation
      Yokohama
    • Related Report
      2007 Annual Research Report
  • [Presentation] Social cognition impairments in Parkinson's Disease.2007

    • Author(s)
      Kawamura, M.
    • Organizer
      Tamagawa-Caltech Joint Workshop 2007 Neural Mechanisms of the Social Mind
    • Place of Presentation
      Machida
    • Related Report
      2007 Annual Research Report
  • [Presentation] Risk-taking tendencies in patients with Parkinson's desease:analysis of the behaviour al pattems in the Iowa gambling task.2007

    • Author(s)
      Kobayakawa, M.・Koyama, S.・mimura, M.・Kawamura, M.
    • Organizer
      37th annual meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego
    • Related Report
      2007 Annual Research Report
  • [Presentation] Emotional impairment in Parkinson's disease.2007

    • Author(s)
      Kawamura, M.・kobayakawa, M.・Koyama, S.・Kondo, M.
    • Organizer
      3rd International Symposium on Dopaminergic and Nondopaminergic Mechanisms in Parkinson's Disease
    • Place of Presentation
      Osaka
    • Related Report
      2007 Annual Research Report
  • [Presentation] Decision making in patients with Parkinson's desease.2007

    • Author(s)
      Kobayakawa, M.・Koyama, S.・Mimura, M.・Kawamura, M.
    • Organizer
      5th International Parkinson's Disease Symposium in Takamatsu
    • Place of Presentation
      Takamatsu
    • Related Report
      2007 Annual Research Report
  • [Presentation] 前頭側頭型痴呆症例に認められた残存機能.2007

    • Author(s)
      緑川晶 & 河村満.
    • Organizer
      第31回 日本高次脳機能障害学会総会
    • Place of Presentation
      和歌山
    • Related Report
      2007 Annual Research Report
  • [Presentation] Parkinson 病症例における意思決定過程-Iowa gamblig taskを用いた検討2007

    • Author(s)
      小早川睦貴, 小山慎一, 三村將 & 河村満.
    • Organizer
      第31回 日本神経心理学会
    • Place of Presentation
      金沢
    • Related Report
      2007 Annual Research Report
  • [Presentation] 運動症状および精神症状を呈した後、社会的認知障害のみが残存した症例.2007

    • Author(s)
      小早川睦貴, 小山慎一 & 河村満.
    • Organizer
      第31回 日本高次脳機能障害学会総会
    • Place of Presentation
      和歌山
    • Related Report
      2007 Annual Research Report
  • [Presentation] Parkinson 病における意思決定能力の評価.2007

    • Author(s)
      小早川睦貴, 小山慎一, 三村將 & 河村満.
    • Organizer
      第1回 Movement Disorders Society, Japan
    • Place of Presentation
      品川
    • Related Report
      2007 Annual Research Report
  • [Presentation] パーキンソン病の意思決定機能-若年性パーキンソニズムの比較.2007

    • Author(s)
      吉村菜穂子, 横地正之 & 河村満.
    • Organizer
      第48回神経学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2007 Annual Research Report
  • [Presentation] パーキンソン病の感情認知に対する視床下核脳深部刺激術の影響.2007

    • Author(s)
      西川奈津子, 伊澤奈々, 沖山亮一, 横地房子, 吉村菜穂子 & 河村満.
    • Organizer
      第48回神経学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2007 Annual Research Report
  • [Book] The Source Generator of Event-Related Potentials with Recognizing Facial Expressions by the Dipole Method. In Breathing, Feeding, and Neuroprotection.2006

    • Author(s)
      Yoshimura N, Masaoka Y, Homma I, Kawamura M
    • Total Pages
      4
    • Publisher
      Springer-Verlag (Tokyo)
    • Related Report
      2006 Annual Research Report
  • [Book] Aging Effects on Facial Expression Recognition: Testing for Their Negative-Emotion Selectivity. In Psychology of Anger(In press)

    • Author(s)
      Suzuki, A.・Hoshino, T.・Shigemasu, K・Kawamura, M.
    • Publisher
      Nova Science Publishers
    • Related Report
      2007 Annual Research Report

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Published: 2006-04-01   Modified: 2018-03-28  

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