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生物活性多環式天然物の効率的全合成研究

Research Project

Project/Area Number 18032078
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Science and Engineering
Research InstitutionWaseda University

Principal Investigator

中田 雅久  Waseda University, 理工学術院, 教授 (50198131)

Co-Investigator(Kenkyū-buntansha) 宇津木 雅之  早稲田大学, 理工学術院, 助手 (70434280)
渡邉 秀昭  早稲田大学, 理工学術院, 助手 (60434312)
井上 将大  早稲田大学, 理工学術院, 助手 (20409642)
武田 博之  早稲田大学, 理工学術院, 助手 (30424807)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥5,600,000 (Direct Cost: ¥5,600,000)
Fiscal Year 2007: ¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 2006: ¥2,800,000 (Direct Cost: ¥2,800,000)
Keywords有機化学 / 合成化学 / 生体関連物質
Research Abstract

不斉触媒反応の開発研究とそれを利用するキラルビルディングブロックスの創製研究を継続して行い、また、それらを活用する生物活性多環式天然物の不斉全合成研究を推進した。(1)α-diazo-β-keto esterの触媒不斉分子内シクロプロパン化反応がtricyclo[4.4.05.7]decene誘導体の構築に有効であり、90%eeを超える生成物を与えることを見出した。(2)タキソールの不斉全合成研究においては、シアン化物イオンの1,4-付加反応によるtrans縮環部位の高立体選択的構築に成功した。また、連続的1,5-ヒドリドシフト、ベンジリデン形成反応によるタキソールのtrans縮環部位をの立体選択的構築に成功した。さらに、Pd触媒によるメチルケトンの分子内アルケニル化が8員環構築に極めで布効であり、ケトンを含むタキソールのB環を91%で与えることを見出した。(2)触媒的不斉分子内シクロプロパン化反応、パン酵母還元により創製したキラルビルディングブロックスを活用し、強力なNGF合成促進活性とκ-opioid受容体の選択的アゴニスト活性を有するerinacine Eの世界初不斉全合成を達成した。歪みのかかった多環式骨格の構築においては、新たに見出した生合成類似のSN2'反応、ベンゾイル基の転位を伴う分子内アルドール反応の活用が成功の鍵であった。(3)(+)-ophiobolin Aの合成研究においては、これまでに構築したスピロCD環と、合理的に設計・合成したA環部分フラグメントをカップリング後、立体選択的水素添加により(+)-ophiobolin Aに存在するすべての不斉中心の構築に成功した。(4)FR182876の不斉全合成研究においては、Heck反応を活用することにより歪みのかかったE,F環部分の構築に成功した。

Report

(2 results)
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (34 results)

All 2008 2007 2006

All Journal Article (13 results) (of which Peer Reviewed: 8 results) Presentation (21 results)

  • [Journal Article] Biomimetic Total Synthesis of (-)-Erinacine E2008

    • Author(s)
      H. Watanabe, M. Nakada
    • Journal Title

      J. Am. Chem. Soc. 130

      Pages: 1150-1151

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthetic Studies on (-)-Scabronine A2008

    • Author(s)
      H. Watanabe, M. Nakada
    • Journal Title

      Tetrahedron Lett. 49

      Pages: 1518-1522

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Construction of the Taxane Skeleton via the Stereoselective Conjugate Addition of Cyanide and the Intramolecular B-Aikyl Suzuki-Miyaura Coupling Reaction2007

    • Author(s)
      M. Utsugi, Y. Kamada, H. Miyamoto, M. Nakada
    • Journal Title

      Tetrahedron Lett. 48

      Pages: 6868-6872

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthetic Studies on (-)-FR182877: Construction of the ABCD Ring System via the Intramolecular Cycloadditions (2)2007

    • Author(s)
      N. Tanaka, T. Suzuki, Y. Hosoya, M. Nakada
    • Journal Title

      Tetrahedron Lett. 48

      Pages: 6488-6492

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthetic Studies on (-)-FR182877: Construction of the ABCD Ring System via the Intramolecular Cycloadditions (1)2007

    • Author(s)
      T. Suzuki, N. Tanaka, T. Matsumura, Y. Hosoya, M. Nakada
    • Journal Title

      Tetrahedron Lett. 48

      Pages: 6483-6487

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enantioselective Preparation of Tricyclo [4.4.0.05,7] decene Derivatives via Catalytic Asymmetric Intramolecular Cyclopropanation of α-Diazo-β-keto Esters2007

    • Author(s)
      R. Ida, M. Nakada
    • Journal Title

      Tetrahedron Lett. 48

      Pages: 4855-4859

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthetic Studies on Phloroglucins: A New Approach to the Bicyclo[3.3.1]nonane System via the Regioselective Ring-opening of the Methoxycyclopropane2007

    • Author(s)
      M. Abe, M. Nakada
    • Journal Title

      Tetrahedron Lett. 48

      Pages: 4873-4877

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure Elucidation and Enantioselective, Protecting Group-Free Total Synthesis of the HMG-CoA Reductase Inhibitor, FR901512 via Catalytic Asymmetric Nozaki-Hiyama Reactions2007

    • Author(s)
      M. Inoue, M. Nakada
    • Journal Title

      J.Am. Chem. Soc. 129

      Pages: 4164-4165

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Studies into Asymmetric Catalysis of Nozaki-Hiyama Allenylation2006

    • Author(s)
      Inoue, M., Nakada.M.
    • Journal Title

      Angew. Chem., Int. Engl. 45

      Pages: 252-255

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Synthetic Studies on (+)-Ophiobolin A : Asymmetric Synthesis of the Spirocyclic CD-Rine Moiety2006

    • Author(s)
      Noguchi, N., Nakada, M.
    • Journal Title

      Org. Lett. 8

      Pages: 2039-2042

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Asymmetric Total Synthesis of Enantiopure (-)-Methyl Jasmonate via Catalytic Asymmetric Intramolecular Cyclopropanation of α-Diazo-β-keto Sulfone2006

    • Author(s)
      Takeda, H., Watanabe, H., Nakada, M.
    • Journal Title

      Tetrahedron 62

      Pages: 8054-8063

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Regioselective Ring-Opening Reaction of the Tricyclo[4.4.0.05,7]dec-2-ene Derivative2006

    • Author(s)
      Abe, M., Nakada, M.
    • Journal Title

      Tetrahedron Lett. 47

      Pages: 6347-6351

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Asymmetric Intramolecular Cyclopropanation Reaction of the α-Diazo-β-keto Sulfones Possessing a Methyl-substituted Phenyl2006

    • Author(s)
      Takeda, H., Nakada, M.
    • Journal Title

      Tetrahedron : Asymmetry 17

      Pages: 2896-2906

    • Related Report
      2006 Annual Research Report
  • [Presentation] ハイパーフォリンの不斉全合成研究2008

    • Author(s)
      阿部正人, 中田雅久
    • Organizer
      日本化学会第88春季年会
    • Place of Presentation
      東京
    • Year and Date
      2008-03-30
    • Related Report
      2007 Annual Research Report
  • [Presentation] (-)-FR182877の全合成研究(2)2008

    • Author(s)
      田中奈津美, 細谷洋介, 中田雅久
    • Organizer
      日本化学会第88春季年会
    • Place of Presentation
      東京
    • Year and Date
      2008-03-29
    • Related Report
      2007 Annual Research Report
  • [Presentation] (-)-FR182877の全合成研究(1)2008

    • Author(s)
      細谷洋介, 田中奈津美, 中田雅久
    • Organizer
      日本化学会第88春季年会
    • Place of Presentation
      東京
    • Year and Date
      2008-03-29
    • Related Report
      2007 Annual Research Report
  • [Presentation] MK8383の不斉全合成研究2008

    • Author(s)
      林 伸行, 中田雅久
    • Organizer
      日本化学会第88春季年会
    • Place of Presentation
      東京
    • Year and Date
      2008-03-29
    • Related Report
      2007 Annual Research Report
  • [Presentation] (+)-bucidarasin Cの不斉全合成研究2008

    • Author(s)
      中原明暢, 中田雅久
    • Organizer
      日本化学会第88春季年会
    • Place of Presentation
      東京
    • Year and Date
      2008-03-29
    • Related Report
      2007 Annual Research Report
  • [Presentation] 抗腫瘍細胞性セスタテルペノイド(+)-Ophiobolin Aの不斉全合成研究2008

    • Author(s)
      綱 和宏, 野口直義, 中田雅久
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] (+)-Ophiobolin Aの不斉全合成研究2008

    • Author(s)
      綱 和宏, 野口直義, 中田雅久
    • Organizer
      日本化学会第88春季年会
    • Place of Presentation
      東京
    • Year and Date
      2008-03-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] (-)-エリナシンEの不斉全合成2008

    • Author(s)
      渡邉秀昭, 中田雅久
    • Organizer
      日本化学会第88春季年会
    • Place of Presentation
      東京
    • Year and Date
      2008-03-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] taxolの収束的不斉全合成研究2008

    • Author(s)
      宇津木雅之, 謙田恭明, 中田雅久
    • Organizer
      日本化学会第88春季年会
    • Place of Presentation
      東京
    • Year and Date
      2008-03-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] taxolの収束的不斉全合成研究2008

    • Author(s)
      宇津木雅之, 鎌田恭明, 中田雅久
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] Biomimetic Total Synthesis of Erinacine E2008

    • Author(s)
      H. Watanabe, M. Nakada
    • Organizer
      9th Annual Florida Heterocyclic and Synthetic IUPAC-Sponsored Conference
    • Place of Presentation
      Florida, USA
    • Year and Date
      2008-03-10
    • Related Report
      2007 Annual Research Report
  • [Presentation] Studies on Convergent and Enantioselective Total Synthesis of Taxol2008

    • Author(s)
      M. Utsugi, Y. Kamada, M. Nakada
    • Organizer
      9th Annual Florida Heterocyclic and Synthetic IUPAC-Sponsored Conference
    • Place of Presentation
      Florida, USA
    • Year and Date
      2008-03-10
    • Related Report
      2007 Annual Research Report
  • [Presentation] First Enantioselective Total Synthesis of FR901512 via the Catalytic Asymmetric Nozaki-Hiyama Reactions2007

    • Author(s)
      M. Nakada
    • Organizer
      Catalysis & Fine Chemicals 2007 (C&FC 2007)
    • Place of Presentation
      Singapore
    • Year and Date
      2007-12-19
    • Related Report
      2007 Annual Research Report
  • [Presentation] ハイパーフォリンの不斉全合成研究2007

    • Author(s)
      阿部正人, 中田雅久
    • Organizer
      第54回有機合成化学協会関東支部シンポジウム(新潟シンポジウム)
    • Place of Presentation
      新潟
    • Year and Date
      2007-12-01
    • Related Report
      2007 Annual Research Report
  • [Presentation] (+)-Phomopsidinの改良不斉全合成2007

    • Author(s)
      林 伸行, 臼井研二, 鈴木孝洋
    • Organizer
      第91回有機合成シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2007-11-08
    • Related Report
      2007 Annual Research Report
  • [Presentation] タキソールの収束的不斉全合成研究2007

    • Author(s)
      宇津木雅之, 鎌田恭明, 中田雅久
    • Organizer
      有機合成化学協会平成19年度「若手研究者のためのセミナー」
    • Place of Presentation
      神奈川
    • Year and Date
      2007-10-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] Development of Catalytic Asymmetric Nozaki-Hiyama Reactions and their Application to Enantioselective Total Synthesis of FR9015122007

    • Author(s)
      M. Nakada
    • Organizer
      14th IUPAC International SymPosium on Orgarlometallic Chemistry Directed Towards Organic Synthesis (OMCOS 14)
    • Place of Presentation
      奈良
    • Year and Date
      2007-08-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] Synthetic Studies on Polycyclic Polyprenylated Acylphloroglucinols2007

    • Author(s)
      M. Nakada
    • Organizer
      第10回有機分子構築法夏の学校
    • Place of Presentation
      長崎
    • Year and Date
      2007-06-23
    • Related Report
      2007 Annual Research Report
  • [Presentation] (+)-ophiobolin Aの不斉全合成研究2007

    • Author(s)
      野口直義, 中田雅久
    • Organizer
      第91回有機合成シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2007-06-13
    • Related Report
      2007 Annual Research Report
  • [Presentation] Design of Catalytic Asymmetric Reactions and their Applications to Enantioselective Total Synthesis of Bioactive Natural Products2007

    • Author(s)
      M. Nakada
    • Organizer
      Molecular Chiraiity 2007 (MC 2007)
    • Place of Presentation
      東京
    • Year and Date
      2007-05-16
    • Related Report
      2007 Annual Research Report
  • [Presentation] hyperforinの不斉全合成研究2007

    • Author(s)
      阿部正人, 中田雅久
    • Organizer
      第53回有機合成化学協会関東支部シンポジウム 横浜シンポジウム
    • Place of Presentation
      横浜
    • Year and Date
      2007-05-11
    • Related Report
      2007 Annual Research Report

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Published: 2006-04-01   Modified: 2018-03-28  

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