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骨・軟骨の恒常性維持におけるケモカイン及びC型レクチンの役割の解明

Research Project

Project/Area Number 18060010
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionThe University of Tokyo

Principal Investigator

岩倉 洋一郎  The University of Tokyo, 医科学研究所, 教授 (10089120)

Co-Investigator(Kenkyū-buntansha) 西城 忍  東京大学, 医科学研究所, 助教 (60396877)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥7,200,000 (Direct Cost: ¥7,200,000)
Fiscal Year 2007: ¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2006: ¥3,600,000 (Direct Cost: ¥3,600,000)
Keywords遺伝子 / 応用動物 / 細胞・組織 / シグナル伝達 / 発生・分化 / 応用植物
Research Abstract

関節は骨・軟骨や滑膜、腱など多種多様な組織で構成される一つの運動器である。正常に機能するためには同一組織内の細胞集団はもちろん、異なる組織間での細胞集団の細胞外環境が重要な役割を担う。我々は疾患モデルマウスを用いて関節炎発症機構の解析を行ってきたが、関節炎関連遺伝子として同定した2遺伝子が関節を構成する因子のうち骨・軟骨形成およびその代謝に関与していることを示唆するデータを得た。これらの知見をふまえ、本研究では最終的に関節という一つの運動器全体における正常な細胞外環境の維持機構を理解することを目的としている。
本年度は、骨髄細胞特異的にケモカインレセプター遺伝子を欠損させたマウスにおいて観察された大理石骨病様の表現型について詳細なメカニズムの解析を進め、このケモカインが破骨細胞あるいは破骨細胞前駆細胞の骨表面への遊走および破骨細胞形成に重要な役割を果たしていることを明らかにした。また、加齢とともに関節付着部症を自然発症するC型レクチン遺伝子欠損マウスの詳細な病態解析を進め、付着部症が後肢足根関節に限局したものではなく、膝関節や脊椎なども標的となっていることが明らかとなった。さらに、関節病変局所における軟骨増殖と骨の異形成とは独立に大腿骨における骨量の低下を見出し、このマウスが付着部症の発症に伴って骨粗鬆症様の表現型を示していることが明らかとなった。さらにこのC型レクチンは正常な骨代謝においても機能していることを示唆するデータを得た。これらの結果から、関節炎関連遺伝子として同定したケモカイン及びC型レクチンが骨・軟骨の恒常性維持において重要な役割を果たしていることが示唆された。

Report

(2 results)
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (87 results)

All 2008 2007 2006 Other

All Journal Article (70 results) (of which Peer Reviewed: 31 results) Presentation (15 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Interleukin-23 restrains regulatory T cell activity to drive T cell-dependent colitis.2008

    • Author(s)
      Izcue A.
    • Journal Title

      Immunity 28

      Pages: 559-570

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Either a Th17 or a Thl effector response can drive autoimmunity: conditions of disease induction affect dominant effector category.2008

    • Author(s)
      Luger D.
    • Journal Title

      J Exp Med 205

      Pages: 799-810

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Kid-mediated chromosome compaction ensures proper nuclear envelope formation.2008

    • Author(s)
      Ohsugi M.
    • Journal Title

      Cell 132

      Pages: 771-782

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deoxynucleic Acids from Cryptococcus neoformans Activate Myeloid Dendritic Cells via a TLR9-Dependent Pathway.2008

    • Author(s)
      Nakamura K.
    • Journal Title

      J Immunol 180

      Pages: 4067-4074

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia.2008

    • Author(s)
      Aujla SJ.
    • Journal Title

      Nat Med 14

      Pages: 275-281

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ozone exposure in a mouse model induces airway hyperreactivity that requires the presence of natural killer T cells and IL-17.2008

    • Author(s)
      Pichavant M.
    • Journal Title

      J Exp Med 205

      Pages: 385-393

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suppressive role of leukocyte cell-derived chemotaxin 2 in mouse anti-type II collagen antibody-induced arthritis.2008

    • Author(s)
      Okamura A.
    • Journal Title

      Arthritis Rheum 58

      Pages: 413-421

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dcir deficiency causes development of autoimmune diseases in mice due to excess expansion of dendritic cells.2008

    • Author(s)
      Fujikado N.
    • Journal Title

      Nat Med 14

      Pages: 176-180

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential roles for IFN-γ and IL-17 in experimental autoimmune uveoretinitis.2008

    • Author(s)
      Yoshimura T.
    • Journal Title

      Int Immunol 20

      Pages: 209-214

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-1β and macrophage migration inhibitory factor (MIF) in dermal fibroblasts mediate UVA-induced matrix metalloproteinase-1 expression.2008

    • Author(s)
      Honda A.
    • Journal Title

      J Dermal Sci 49

      Pages: 63-72

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Negative feedback regulation of lipopolysaccharide-induced inducible nitricoxide synthase gene expression by heme oxygenase-1 induction in macrophages.2008

    • Author(s)
      Ashino T.
    • Journal Title

      Mol Immunol 45

      Pages: 2106-2115

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dectin-1 is not required for the host defense to Cryptococcus neoformans.2007

    • Author(s)
      Nakamura K.
    • Journal Title

      Microbiol Immunol 51

      Pages: 1115-1119

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Melanocortin 2 receptor is required for adrenal gland development, steroidogenesis, and neonatal gluconeogenesis.2007

    • Author(s)
      Chida D.
    • Journal Title

      Proc Natl Acad Sci USA 104

      Pages: 18205-18210

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inflammasome-mediated production of IL-1β is required for neutrophil recruitment against Staphylococcus aureus in vivo.2007

    • Author(s)
      Miller LS.
    • Journal Title

      J Immunol 179

      Pages: 6933-6942

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Blocking of IL-6 signaling pathway prevents CD4+ T cell-mediated colitis in a Th17-independent manner.2007

    • Author(s)
      Noguchi D.
    • Journal Title

      Int Immunol 19

      Pages: 1431-1440

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Peripheral TNFα, but not peripheral IL-1, requires endogenous IL-1 or TNFα induction in the brain for the febrile response.2007

    • Author(s)
      Chida D.
    • Journal Title

      Biochem Biophys Res Commun 364

      Pages: 765-770

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-type II collagen antibody accelerates arthritis via cells in IL-1 receptor antagonist-deficient mice.2007

    • Author(s)
      Kagari T.
    • Journal Title

      Eur J Immunol 37

      Pages: 2269-2278

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-23 enhances host defense against vaccinia virus infection via a mechanism partly involving IL-17.2007

    • Author(s)
      Kohyama S.
    • Journal Title

      J Immunol 179

      Pages: 3917-3925

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Systemic administration of IL-23 induces potent antitumor immunity primarily mediated through Th1-type response in association with the endogenously expressed IL-122007

    • Author(s)
      Kaiga T.
    • Journal Title

      J Immunol 178

      Pages: 7571-7580

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-1 is not essential for expression of inducible NOS in hepatocytes induced by lipopolysaccharide in vivo.2007

    • Author(s)
      Takagi K.
    • Journal Title

      Nitric Oxide 16

      Pages: 433-441

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IFN-γ protects cerulein-induced acute pancreatitis by repressing NF-k activation.2007

    • Author(s)
      Hayashi T.
    • Journal Title

      J Immunol 178

      Pages: 7385-7394

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors.2007

    • Author(s)
      Hara H.
    • Journal Title

      Nat Immunol 8

      Pages: 619-629

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Loss of DExD/H box RNA helicase LGP2 manifests disparate antiviral responses.2007

    • Author(s)
      Venkataraman T.
    • Journal Title

      J Immunol 178

      Pages: 6444-6455

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lipopolysaccharide promotes and augments metal allergies in mice, dependent on innate immunity and histidine decarboxylase.2007

    • Author(s)
      Sato N.
    • Journal Title

      Clin Exp Allergy 37

      Pages: 743-751

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-28 elicits antitumor responses against murine fibrosarcoma.2007

    • Author(s)
      Numasaki M.
    • Journal Title

      J Immunol 178

      Pages: 5086-5098

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A new murine model to define the critical pathologic and therapeutic mediators of polymyositis.2007

    • Author(s)
      Sugihara T.
    • Journal Title

      Arthritis Rheum 56

      Pages: 1304-1314

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Natural killer T cells from interleukin-4-deficient mice are defective in early interferon-γ production in response to α-galactosylceramide.2007

    • Author(s)
      Togashi Y.
    • Journal Title

      Cancer Sci 98

      Pages: 721-725

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-17-mediated regulation of innate and acquired immune response against pulmonary Mycobacterium bovis bacille Calmette-Guerin infection2007

    • Author(s)
      Umemura M.
    • Journal Title

      J Immunol 178

      Pages: 3786-3796

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of interferon-γ in Vα14+natural killer T ce11-mediated host defense against Streptococcus pneumoniae infection in murine lungs.2007

    • Author(s)
      Nakamatsu M.
    • Journal Title

      Microbes Infect 9

      Pages: 364-374

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17.2007

    • Author(s)
      Nakae S.
    • Journal Title

      J Leukocyte Biol 81

      Pages: 1258-1268

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intestinal inflammation downregulates smooth muscle CPI-17 through induction of TNF-α and causes motility disorders.2007

    • Author(s)
      Ohama T.
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol 292

      Pages: 1429-1438

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Loss of DExD/H Box RNA Helicase LGP2 Manifests Disparate Antiviral Responses.2007

    • Author(s)
      Venkataraman, T.
    • Journal Title

      J. Immunol. 178(10)

      Pages: 6444-6455

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Lipopolysaccharide promotes and augments metal allergies in mice, dependent on innate immunity and histidine decarboxylase.2007

    • Author(s)
      Sato, N.
    • Journal Title

      Clin. Exp. Allergy 37(5)

      Pages: 743-751

    • Related Report
      2006 Annual Research Report
  • [Journal Article] IL-28 Elicits Antitumor Responses against Murine Fibrosarcoma.2007

    • Author(s)
      Numasaki, M.
    • Journal Title

      J. Immunol. 178(8)

      Pages: 5086-5098

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A new murine model to define the critical pathologic and therapeutic mediators of polymyositis.2007

    • Author(s)
      Sugihara, T
    • Journal Title

      Arthritis Rheum. 56(4)

      Pages: 1304-1314

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Natural killer T cells from interleukin-4-deficient mice are defective in early interferon-γ production in response to α-galactosylceramide.2007

    • Author(s)
      Togashi, Y.
    • Journal Title

      Cancer Sci. 98(5)

      Pages: 721-725

    • Related Report
      2006 Annual Research Report
  • [Journal Article] IL-17-Mediated Regulation of Innate and Acquired Immune Response against Pulmonary Mycobacterium bovis Bacille Calmette-Guerin Infection.2007

    • Author(s)
      Umemura, M.
    • Journal Title

      J. Immunol. 178(6)

      Pages: 3786-3796

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Role of interferon-γ in Vαl4+natural killer T cell-mediated host defense against Streptococcus pneumoniae infection in murine lungs.2007

    • Author(s)
      Nakamatsu, M.
    • Journal Title

      Microbes Infect. 9(3)

      Pages: 364-374

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17.2007

    • Author(s)
      Nakae, S.
    • Journal Title

      J. Leukoc. Biol. 81(5)

      Pages: 1258-1268

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Interleukin-1β Driven Inflammation Promotes the Development and Invasiveness of Chemical Carcinogen-Induced Tumors.2007

    • Author(s)
      Krelin, Y.
    • Journal Title

      Cancer Res. 67(3)

      Pages: 1062-1071

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Mast cells contribute to initiation of autoantibody-mediated arthritis via IL-1.2007

    • Author(s)
      Nigrovic, PA.
    • Journal Title

      Proc. Natl. Acad. Sci. USA 104(7)

      Pages: 2325-2330

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A novel DNA vaccine targeting macrophage migration inhibitory factor protects joints from inflammation and destruction in murine models of arthritis.2007

    • Author(s)
      Onodera, S.
    • Journal Title

      Arthritis Rheum. 56(2)

      Pages: 521-530

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Crucial Role of Bysl in Mammalian Preimplantation Development as an Integral Factor for 40S Ribosome Biogenesis.2007

    • Author(s)
      Adachi, K.
    • Journal Title

      Mol. Cell. Biol. 27(6)

      Pages: 2202-2214

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Effect of interleukin-6 neutralization on CYP3A11 and metallothionein-1/2 expressions in arthritic mouse liver.2007

    • Author(s)
      Ashino, T.
    • Journal Title

      Eur. J. Pharmacol. 558(1-3)

      Pages: 199-207

    • Related Report
      2006 Annual Research Report
  • [Journal Article] T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+Th cells that cause autoimmune arthritis.2007

    • Author(s)
      Hirota, K.
    • Journal Title

      J. Exp. Med. 204(1)

      Pages: 41-47

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans.2007

    • Author(s)
      Saijo, S.
    • Journal Title

      Nat. Immunol. 8(1)

      Pages: 39-46

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Nuclear import of the pre-integration complex is blocked upon infection by HIV-I in mouse cells.2007

    • Author(s)
      Tsurutani, N.
    • Journal Title

      J. Virol. 81(2)

      Pages: 677-688

    • Related Report
      2006 Annual Research Report
  • [Journal Article] IL-17と新規Il-17産生ヘルパーT細胞サブセット2007

    • Author(s)
      岩倉 洋一郎
    • Journal Title

      感染・炎症・免疫 (印刷中)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction.2006

    • Author(s)
      Sato, K.
    • Journal Title

      J. Exp. Med. 203(12)

      Pages: 2673-2682

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Interferon-γ is causatively involved in experimental inflammatory bowel disease in mice.2006

    • Author(s)
      Ito, R.
    • Journal Title

      Clin. Exp. Immunol. 146(2)

      Pages: 330-338

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Protective Roles of Mast Cells and Mast cell-Derived TNF in Murine Malaria.2006

    • Author(s)
      Furuta, T.
    • Journal Title

      J. Immunol. 177(5)

      Pages: 3294-3302

    • Related Report
      2006 Annual Research Report
  • [Journal Article] IL-1β-deficient mice are resistant to induction of experimental SLE.2006

    • Author(s)
      Voronov, E.
    • Journal Title

      Eur. Cytokine Netw. 17(2)

      Pages: 109-116

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Identification of arthritis-related gene clusters by microarray analysis of two independent mouse models for rheumatoid arthritis.2006

    • Author(s)
      Fujikado, N.
    • Journal Title

      Arthritis Res. Ther. 8(4)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] The Muscle Protein Dok-7 Is Essential for Neuromuscular Synaptogenesis.2006

    • Author(s)
      Okada, K.
    • Journal Title

      Science 312(5781)

      Pages: 1802-1805

    • Related Report
      2006 Annual Research Report
  • [Journal Article] IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis.2006

    • Author(s)
      Komiyama, Y.
    • Journal Title

      J. Immunol. 177(1)

      Pages: 566-573

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Antiangiogenic and Antitumor Activities of IL-27.2006

    • Author(s)
      Shimizu, M.
    • Journal Title

      J. Immunol. 176(12)

      Pages: 7317-7324

    • Related Report
      2006 Annual Research Report
  • [Journal Article] IL-1β Breaks Tolerance through Expansion of CD25+Effector T Cells.2006

    • Author(s)
      O'Sullivan, BJ.
    • Journal Title

      J. Immunol. 176(12)

      Pages: 7278-7287

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Signaling of vascular endothelial growth factor receptor- 1 tyrosine kinase promotes rheumatoid arthritis through activation of monocyte/macrophages.2006

    • Author(s)
      Murakami, M.
    • Journal Title

      Blood 108(6)

      Pages: 1849-1856

    • Related Report
      2006 Annual Research Report
  • [Journal Article] The IL-23/IL-17 axis in inflammation.2006

    • Author(s)
      Iwakura, Y.
    • Journal Title

      J. Clin. Invest. 116(5)

      Pages: 1218-1222

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Endogenous Interleukin (IL)-1α and IL-1β Are Crucial for Host Defense against Disseminated Candidiasis.2006

    • Author(s)
      Vonk, AG.
    • Journal Title

      J. Infect. Dis. 193(10)

      Pages: 1419-1426

    • Related Report
      2006 Annual Research Report
  • [Journal Article] IL-1β, but not IL-1α, is required for antigen-specific T cell activation and the induction of local inflammation in the delayed-type hypersensitivity responses.2006

    • Author(s)
      Nambu, A.
    • Journal Title

      Int. Immunol. 18(5)

      Pages: 701-712

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Combined IL-6 and IL-1 deficiency causes obesity in young mice.2006

    • Author(s)
      Chida, D.
    • Journal Title

      Diabetes 55(4)

      Pages: 971-977

    • Related Report
      2006 Annual Research Report
  • [Journal Article] CD28-dependent differentiation into the effector/memory phenotype is essential for induction of arthritis in interleukin-1 receptor antagonist-deficient mice.2006

    • Author(s)
      Kotani, M.
    • Journal Title

      Arthritis Rheum. 54(2)

      Pages: 473-481

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Abnormal T cell activation caused by the imbalance of the IL-1/IL-1R antagonist system is responsible for the development of experimental autoimmune encephalomyelitis.2006

    • Author(s)
      Matsuki, T.
    • Journal Title

      Int. Immunol. 18(2)

      Pages: 399-407

    • Related Report
      2006 Annual Research Report
  • [Journal Article] The role of TNFα and IL-17 in the development of excess IL-1 signaling-induced inflammatory diseases in IL-1 receptor antagonist-deficient mice.2006

    • Author(s)
      Ishigame, H.
    • Journal Title

      Ernst Schering Res. Found. Workshop 56

      Pages: 129-153

    • Related Report
      2006 Annual Research Report
  • [Journal Article] サイトカインと自己免疫疾患2006

    • Author(s)
      角田 茂
    • Journal Title

      EXPERT膠原病・リウマチ (改訂第2版)

      Pages: 42-47

    • Related Report
      2006 Annual Research Report
  • [Journal Article] HTLV-Iによる自己免疫性関節炎発症機構-モデル動物の研究-2006

    • Author(s)
      西城 忍
    • Journal Title

      分子リウマチ 3(4)

      Pages: 292-298

    • Related Report
      2006 Annual Research Report
  • [Journal Article] IL-17の自己免疫疾患における役割2006

    • Author(s)
      西城 忍
    • Journal Title

      Medical Science Digest 32(12)

      Pages: 538-541

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 関節リウマチの疾患モデル2006

    • Author(s)
      藤門 範行
    • Journal Title

      治療学 40(7)

      Pages: 745-748

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 自己免疫疾患発症における樹状細胞の役割2006

    • Author(s)
      西城 忍
    • Journal Title

      炎症と免疫 14(4)

      Pages: 79-85

    • Related Report
      2006 Annual Research Report
  • [Presentation] 関節炎における骨破壊メカニズム2007

    • Author(s)
      岩倉洋一郎
    • Organizer
      第22回日本整形外科学会基礎学術集会
    • Place of Presentation
      浜松
    • Year and Date
      2007-10-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] The role of cytokines in the development of autoimmune arthritis.2007

    • Author(s)
      Yoichiro Iwakura
    • Organizer
      The 2nd East Asian Group of Rheumatology Meeting (EAGOR 2007)
    • Place of Presentation
      Seoul
    • Year and Date
      2007-05-19
    • Related Report
      2007 Annual Research Report
  • [Presentation] Expression of CXCR4 in T cells is crucial for the development of collagen-induced arthritis.2007

    • Author(s)
      Soo-hyun Chung
    • Organizer
      The 14th East Asia Joint Symposium on Biomedical Research
    • Place of Presentation
      Tokyo
    • Related Report
      2007 Annual Research Report
  • [Presentation] Dectin-1 plays asn important role in host defense against the pathogenic fungus Pneumocystis carinii.2007

    • Author(s)
      Shinobu Saijo
    • Organizer
      The 13th International Congress of Immunology
    • Place of Presentation
      Rio de Janeiro
    • Related Report
      2007 Annual Research Report
  • [Presentation] Identification of dendritic cell immunoreceptor as a novel arthritis-related gene by transcriptome analysis of rheumatoid arthritis model mice.2007

    • Author(s)
      Noriyuki Fujika do
    • Organizer
      The 13th International Congress of Immunology
    • Place of Presentation
      Rio de Janeiro
    • Related Report
      2007 Annual Research Report
  • [Presentation] The role of cytokines in the development of autoimmune arthritis.2007

    • Author(s)
      Yoichiro Iwakura
    • Organizer
      The 4th International Leukocyte Signal Transduction Workshop
    • Place of Presentation
      Rhodes
    • Related Report
      2007 Annual Research Report
  • [Presentation] Rheumatoid arthritis models generated by using transgenic techniques.2007

    • Author(s)
      Yoichiro Iwakura
    • Organizer
      19th Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB)
    • Place of Presentation
      Seoul
    • Related Report
      2007 Annual Research Report
  • [Presentation] Roles of C-type lectins in immune responses.2007

    • Author(s)
      Yoichiro Iwakura
    • Organizer
      第30回日本分子生物学会、第80回日本生化学会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] The roles of C-type lectins in the host defense against infection and homeostasis of the immune system2007

    • Author(s)
      Yoichiro Iwakura
    • Organizer
      第37回日本免疫学会総会・学術集会
    • Place of Presentation
      品川
    • Related Report
      2007 Annual Research Report
  • [Presentation] Dendritic cell immunoreceptor deficiency causes development of autoimmune diseases in mice due to excess expansion of dendritic cells2007

    • Author(s)
      Noriyuki Fujikado
    • Organizer
      第37回日本免疫学会総会・学術集会
    • Place of Presentation
      品川
    • Related Report
      2007 Annual Research Report
  • [Presentation] A C-type lectin that involved in host defense against fungi plays an important role in the development of arthritis2007

    • Author(s)
      Shinobu Saijo
    • Organizer
      第37回日本免疫学会総会・学術集会
    • Place of Presentation
      品川
    • Related Report
      2007 Annual Research Report
  • [Presentation] Dectin-1の生体防御機構における役割2007

    • Author(s)
      西城忍
    • Organizer
      第51回日本医真菌学会総会
    • Place of Presentation
      高山
    • Related Report
      2007 Annual Research Report
  • [Presentation] C型レクチンレセプターDCIRの関節炎発症における役割2007

    • Author(s)
      藤門範行
    • Organizer
      第72回日本インターフェロン・サイトカイン学会
    • Place of Presentation
      京都
    • Related Report
      2007 Annual Research Report
  • [Presentation] Identification of a novel arthritis-related gene by transcriptome analysis of arthritis model mice2007

    • Author(s)
      Noriyuki Fujikado
    • Organizer
      第54回日本実験動物学会総会
    • Place of Presentation
      江戸川
    • Related Report
      2007 Annual Research Report
  • [Presentation] Dectin-1の生体防御機構における役割2007

    • Author(s)
      西城忍
    • Organizer
      第54回日本実験動物学会総会
    • Place of Presentation
      江戸川
    • Related Report
      2007 Annual Research Report
  • [Remarks]

    • URL

      http://www.ims.u-tokyo.ac.jp/cem_dcb/index.html

    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] 樹状細胞免疫受容体遺伝子ノックアウト疾患モデル動物2007

    • Inventor(s)
      岩倉洋一郎
    • Industrial Property Rights Holder
      岩倉洋一郎
    • Filing Date
      2007-02-09
    • Related Report
      2006 Annual Research Report

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Published: 2006-04-01   Modified: 2018-03-28  

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