Organic/Inorganic Hybrid Catalysts with Metalloenzyme Functions

• Project/Area Number: 18065018
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering
• Research Institution: Kyushu University
• Principal Investigator: HISAEDA Yoshio Kyushu University, 大学院・工学研究院, 教授 (70150498)
• Project Period (FY): 2006 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥32,000,000 (Direct Cost: ¥32,000,000); Fiscal Year 2009: ¥8,000,000 (Direct Cost: ¥8,000,000); Fiscal Year 2008: ¥8,000,000 (Direct Cost: ¥8,000,000); Fiscal Year 2007: ¥8,000,000 (Direct Cost: ¥8,000,000); Fiscal Year 2006: ¥8,000,000 (Direct Cost: ¥8,000,000)
• Keywords: ビタミンB_<12> / コバルト錯体 / 人工酵素 / ハイブリッド触媒 / 脱ハロゲン化反応 / 環拡大反応 / 光増感反応 / 無毒化 / ビタミンB12 / 二酸化チタン / 二量化反応 / 有機ラジカル / DDT分解反応 / ヒ素の無毒化 / 光増感剤 / ビタミン B12 / DDT 分解反応 / 人血清アルブミン / 光照射 / ハイプリッド触媒 / 可視光照射

Research Abstract

The metalloenzyme is a nano hybrid catalyst in nature, and one of the ideal catalyst with an environmental-friendly process. In the present study, organic and inorganic hybrid catalysts with metalloenzyme functions were developed by the combination of the mental complexes and the nanomaterials. In order to construct a good catalytic system, we prepared various nanomaterials with vitamin B12 activities. These bioinspired catalysts are very interesting from the viewpoint of green chemistry.

Research Products

• [Journal Article] Photo-Induced Ring-Expansion Reactions Mediated by B12-TiO2 Hybrid Catalyst (2010)
  • Author(s): Izumi, S.; Shimakoshi, H.; Abe, M.; Hisaeda, Y.
  • Journal Title: Dalton Trans. 39,No.13 Pages: 3302-3307
  • Peer Reviewed
• [Journal Article] Synthesis, Characterization and Catalytic Function of B12-Hyperbranched Polymer (2010)
  • Author(s): Tahara, K.; Shimakoshi, H.; Tanaka, A.; Hisaeda, Y.
  • Journal Title: Dalton Trans. 39,No.12 Pages: 3035-3042
  • Peer Reviewed
• [Journal Article] Preparation and Reactivity of B12-TiO2 Hybrid Catalyst Immobilized on Glass Plate (2010)
  • Author(s): Shimakoshi, H.; Abiru, M.; Kuroiwa, K.; Kimizuka, N.; Watanabe, M.; Hisaeda, Y.
  • Journal Title: Bull. Chem. Soc. Jpn. 82,No.2 Pages: 170-172
  • Peer Reviewed
• [Journal Article] Synthesis and Catalysis of B12-core-shell- Hyperbranched Polymer (2010)
  • Author(s): Shimakoshi, H.; Nishi, M.; Tanaka, A.; Chikama, K.; Hisaeda, Y.
  • Journal Title: Chem. Lett. 39,No.1 Pages: 22-23
  • Peer Reviewed
• [Journal Article] Synthesis and Catalysis of B_<12>-core-shell-Hyperbranched Polymer (2010)
  • Author(s): Shimakoshi, H., at al
  • Journal Title: Chem.Lett. 39 Pages: 22-23
  • Peer Reviewed
• [Journal Article] Preparation and Reactivity of B_<12>-TiO_2 Hybrid Catalyst Immobilized on Glass Plate (2010)
  • Author(s): Shimakoshi, H., at al
  • Journal Title: Bull.Chem.Soc.Jpn. 82 Pages: 170-172
  • Peer Reviewed
• [Journal Article] Synthesis, Characterization and Catalytic Function of B_<12>-Hyperbranched Polymer (2010)
  • Author(s): Tahara, K., at al
  • Journal Title: Dalton Trans. 39 Pages: 3035-3042
  • Peer Reviewed
• [Journal Article] Photo-Induced Ring-Expansion Reactions Mediated by B_<12>-TiO_2 Hybrid Catalyst (2010)
  • Author(s): Izumi, S., at al
  • Journal Title: Dalton Trans. 39 Pages: 3302-3307
  • Peer Reviewed
• [Journal Article] Synthesis of a novel Sn(IV)porphycene-ferrocene triad linked by axial coordination and solvent polarity effect in photoinduced charge separation process (2010)
  • Author(s): Maeda, D., at al
  • Journal Title: Inorg.Chem. 49 Pages: 2872-2880
  • Peer Reviewed
• [Journal Article] Vitamin B12 Model Complex Catalyzed Methyl Transfer Reaction to Alkylthiol under Electrochemical Conditions with Sacrificial Electrode (2009)
  • Author(s): Pan, L.; Shimakoshi, H.; Masuko, T.; Hisaeda, Y.
  • Journal Title: Dalton Trans. No.44 Pages: 9898-9905
  • Peer Reviewed
• [Journal Article] Green molecular transformation by B12-TiO2 hybrid catalyst as an alternative to tributyltin hydride (2009)
  • Author(s): Shimakoshi, H.; Abiru, M.; Izumi, S.; Hisaeda, Y.
  • Journal Title: Chem. Commun. No.42 Pages: 6427-6429
  • Peer Reviewed
• [Journal Article] B12-TiO2 Hybrid Catalyst for Dehalogenation of Organic Halides (2009)
  • Author(s): Shimakoshi, H.; Sakumori E.; Kaneko, K.; Hisaeda, Y.
  • Journal Title: Chem. Lett. 38,No.5 Pages: 468-469
  • Peer Reviewed
• [Journal Article] Methyl Transfer from a Hydrophobic Vitamin B12 Derivative to Arsenic Trioxide (2009)
  • Author(s): Nakamura, K.; Hisaeda, Y.; Pan, L.; Yamauchi, H.
  • Journal Title: J. Organometal. Chem. No.694 Pages: 916-921
  • Peer Reviewed
• [Journal Article] Electrochemical Methyl-transfer Reaction to Alkylthiol Catalyzed by Hydrophobic Vitamin B12 (2009)
  • Author(s): Pan, L.; Shimakoshi, H.; Hisaeda, Y.
  • Journal Title: Chem. Lett. 38,No.1 Pages: 26-27
  • NAID: 130004425326
  • Peer Reviewed
• [Journal Article] B_12-TiO_2 Hybrid Catalyst for Dehalogenation of Organic Halides (2009)
  • Author(s): Shimakoshi, H.
  • Journal Title: Chem.Lett. 38 Pages: 468-469
  • Peer Reviewed
• [Journal Article] Organic Films Containing Trinuclear Ruthenium Clusters that Exhibit Redox State-dependent Heat-shielding Characteristics (2009)
  • Author(s): Tomiyasu, Y., at al
  • Journal Title: Chem.Lett. 38 Pages: 492-493
  • Peer Reviewed
• [Journal Article] Electron Transfer in Supramolecular Donor-Acceptor Dyad of Zinc Porphycene (2009)
  • Author(s): Fujitsuka, M. ,at al
  • Journal Title: J.Phys.Chem.A 113 Pages: 3330-3335
  • Peer Reviewed
• [Journal Article] Syntheses and Photophysical Behavior of Porphyrin Isomer Sn(IV) Complexes (2009)
  • Author(s): Maeda, D., at al
  • Journal Title: Inorg.Chem. 48 Pages: 9853-9860
  • Peer Reviewed
• [Journal Article] Green molecular transformation by B_<12>-TiO_2 hybrid catalyst as an alternative to tributyltin hydride (2009)
  • Author(s): Shimakoshi, H., at al
  • Journal Title: Chem.Commun. Pages: 6427-6429
  • Peer Reviewed
• [Journal Article] The Single- and Double-Strand Cleavage of DNA by a Cationic Dicobalt Complex by Vsible Light (2009)
  • Author(s): Shimakoshi, H., at al
  • Journal Title: Bull.Chem.Soc.Jpn. 82 Pages: 1386-1392
  • Peer Reviewed
• [Journal Article] Carboxylate-Modified New Oxo-Centered Triruthenium Cluster Compounds with CO and Solvent Ligands.An X-Ray Structure of [Ru_3O(C_2H_5CO_2)_6(CO)(thf)_2] (2009)
  • Author(s): Inatomi, A., at al
  • Journal Title: Eur.J.Inorg.Chem. Pages: 4830-4836
  • Peer Reviewed
• [Journal Article] Vitamin B_<12> Model Complex Catalyzed Methyl Transfer Reaction to Alkylthiol under Electrochemical Conditions with Sacrificial Electrode (2009)
  • Author(s): Pan, L., at al
  • Journal Title: Dalton Trans. 38 Pages: 9898-9905
  • Peer Reviewed
• [Journal Article] Meso-unsubstituted Iron Corrole in Hemoproteins : Remarkable Differences in Effects on Peroxidase Activities between Myoglobin and Horseradish Peroxidase (2009)
  • Author(s): Matsuo, T., at al
  • Journal Title: J.Am.Chem.Soc. 131 Pages: 15124-15125
  • Peer Reviewed
• [Journal Article] Synthesis and Photochemical Property of a New Molybdenum Porphycene Complex (2009)
  • Author(s): Maeda, D.; Shimakoshi, H.; Abe, M.; Hisaeda, Y.
  • Journal Title: Dalton Trans. No.1 Pages: 140-145
• [Journal Article] Synthesisand Photochemical Propertyof a New Molybdenum Porphycene Complex (2009)
  • Author(s): Maeda, D.
  • Journal Title: Dalton Trans Pages: 140-145
  • Peer Reviewed
• [Journal Article] Electrochemical Methyl-transfer Reaction to Alkylthiol Catalyzed by Hydrophobic Vitamin B_<12> (2009)
  • Author(s): Pan, L.
  • Journal Title: Chem. Lett 38 Pages: 26-27
  • Peer Reviewed
• [Journal Article] Molecular Recognition of Redox-Switchable Bis-crowns Moieties Assembled on Dicobalt Complex (2009)
  • Author(s): Shimakoshi, H.
  • Journal Title: Inorg. Chem 48 Pages: 1045-1052
  • Peer Reviewed
• [Journal Article] Methyl Transfer from a Hydrophobic Vitamin B12 Derivative to Arsenic Trioxide (2009)
  • Author(s): Nakamura, K.
  • Journal Title: J. Organometal. Chem Pages: 916-921
  • Peer Reviewed
• [Journal Article] etoxification System for Inorganic Arsenic: Transformation of Arsenic Trioxide into Trimethylarsine Oxide (TMAO) by Vitamin B12 Derivatives and Conversion of TMAO into Arsenobetaine (2008)
  • Author(s): Nakamura, K.; Hisaeda, Y.; Pan, L.; Yamauchi, H.
  • Journal Title: Chem. Commun. No.41 Pages: 5122-5124
  • Peer Reviewed
• [Journal Article] Detoxification System for Inorganic Arsenic: Transformation of Arsenic Trioxide into Trimethylarsine Oxide (TMAO) by Vitamin B12 Derivatives and Conversion of TMAO into Arsenobetaine (2008)
  • Author(s): Nakamura, K.; Hisaeda, Y.; Pan, L.; Yamauchi, H.
  • Journal Title: Chem. Commun. No.41 Pages: 5122-5124
• [Journal Article] Photophysical and Photosensitizing Properties of Brominated Porphycenes (2008)
  • Author(s): Shimakoshi, H.; Baba, T.; Iseki, Y.; Aritome, I.; Endo, A.; Adachi, C.; Hisaeda, Y
  • Journal Title: Chem. Commun. No.25 Pages: 2882-2884
• [Journal Article] Photophysical and Photocatalytic Properties of P-Sulfonatoporphycenes (2008)
  • Author(s): Baba, T.
  • Journal Title: Chem. Lett 37 Pages: 264-265
  • Peer Reviewed
• [Journal Article] Photophysical and Photosensitizing Properties of Brominated Porphycenes (2008)
  • Author(s): Shimakoshi, H.
  • Journal Title: Chem. Commun Pages: 2882-2884
  • Peer Reviewed
• [Journal Article] Photosensitizing Properties of the Porphycene Immobilized in Sol-Gel Derived Silica Coatina Films (2008)
  • Author(s): Shimakoshi, H.
  • Journal Title: Tetrahedron Lett 49 Pages: 6198-6201
  • Peer Reviewed
• [Journal Article] Detoxification System for Inorganic Arsenic: Transformation of Arsenic Trioxide into Trimethylarsine Oxide (TMAO) by Vitamin B12 Derivatives and Conversion of TMAO into Arsenobetaine (2008)
  • Author(s): Nakamura, K.
  • Journal Title: Chem. Commun Pages: 5122-5124
  • Peer Reviewed
• [Journal Article] Enhanced Reactivity of Hydrophobic Vitamin B12 towards the Dechlorination of DDT in Ionic Liquid (2007)
  • Author(s): Jabbar, M.A.; Shimakoshi, H.; Hisaeda, Y.
  • Journal Title: Chem. Commun. Pages: 1653-1655
  • Peer Reviewed
• [Journal Article] Enhanced Reactivity of Hydrophobic Vitamin B12 towards the Dechlorination of DDT in Ionic Liquid (2007)
  • Author(s): Jabbar, M. A.; Shimakoshi, H.; Hisaeda, Y.
  • Journal Title: Chem. Commun. Pages: 1653-1655
• [Journal Article] Synthesis and characterization of vitamin B12-hyperbranched polymer (2007)
  • Author(s): Tahara, T.; Shimakoshi, H.; Tanaka, A.; Hisaeda, Y.
  • Journal Title: Tetrahedron Lett. 48, No.29 Pages: 5065-5068
• [Journal Article] Enhanced Reactivity of Hydrophobic Vitamin B_12 towards the Dechlorination of DDT in Ionic Liquid (2007)
  • Author(s): Jabbar, M., A.,
  • Journal Title: Chem. Commun. Pages: 1653-1655
  • Peer Reviewed
• [Journal Article] Synthesis and characterization of vitamin B_12-hyperbranched polymer (2007)
  • Author(s): Tahara, T.
  • Journal Title: Tetrahedron Lett. 48 Pages: 5065-5068
  • Peer Reviewed
• [Journal Article] Porphyrinoid Chemistry in Hemoprotein Matrix: Detection and Reactivities of Iron(IV)-Oxo Species of Porphycene Incorporated into Horseradish Peroxidase (2007)
  • Author(s): Matsuo, T.
  • Journal Title: J. Am. Chem. Soc. 129 Pages: 12906-12907
  • Peer Reviewed
• [Journal Article] Organic/Inorganic Hybrid Nanomaterials with Vitamin B12 Functions, Hisaeda (2006)
  • Author(s): Hisaeda,Y.; Masuko, T.; Hanashima, E.; Hayashi T.
  • Journal Title: Sci. Tech. Adv. Mater. 7 Pages: 655-661
  • Peer Reviewed
• [Journal Article] Organic/Inorganic Hybrid Nanomaterials with Vitamin B12 Functions (2006)
  • Author(s): Hisaeda, Y.; Masuko, T.; Hanashima, E.; Hayashi T.
  • Journal Title: Sci. Tech. Adv. Mater. 7 Pages: 655-661
• [Journal Article] Organic/Inorganic Hybrid Nanomaterials with Vitamin B_<12> Functions (2006)
  • Author(s): Y.Hisaeda, et al.
  • Journal Title: Sci. Tech. Adv. Mater. 7・7 Pages: 655-661
• [Journal Article] Oxo(2,3,6,7,12,13,16,17-octaethylporphycenato) molybdenum(V) hexamolybdate (2006)
  • Author(s): D.Maeda, et al.
  • Journal Title: Acta Cryst.E E62
• [Journal Article] 1,1'-(Ethenylidene)bis(4-chlorobenzene) (2006)
  • Author(s): M.A.Jabbar, et al.
  • Journal Title: Acta Cryst. C 61・11
• [Journal Article] Construction of glycosylated myoglobins by reconstitutional method (2006)
  • Author(s): T.Matsuo, et al.
  • Journal Title: Chem. Commun. Pages: 3131-3133
• [Journal Article] Ligand Binding Properties of Two Kinds of Reconstituted Myoglobins with Iron Porphycene Having Propionates : Effect of β-Pyrrolic Position of Two Propionate Side Chains in Porphycene Framework (2006)
  • Author(s): T.Matsuo, et al.
  • Journal Title: J. Inorg. Biochem 100 Pages: 1265-1271
• [Journal Article] Crystal Structure and Peroxidase Activity of Myoglobin Reconstituted with Iron Porphycene (2006)
  • Author(s): T.Hayashi et al.
  • Journal Title: Inorg. Chem. 45・26 Pages: 10530-10536
• [Presentation] Electrochemical Methy-transfer Reaction Catalyzed by Hydrophobic Vitamin B_12 Using Sacrificial Electrode (2009)
  • Author(s): Hisaeda, Y.
  • Organizer: 216th ECS Meeting
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2009-10-08
• [Presentation] Bio-inspired Catalists with Vitamin B_<12> Enzyme Functions (2009)
  • Author(s): Hisaeda, Y.
  • Organizer: 14th International Conference on Biological Inorganic Chemistry (ICBIC 14)
  • Place of Presentation: Nagoya, Japan
  • Year and Date: 2009-07-28
• [Presentation] Electrochemical Methy-transfer Reaction Catalyzed by Hydrophobic Vitamin B12 Using Sacrificial Electrode (2009)
  • Author(s): Hisaeda, Y.
  • Organizer: 216th ECS Meeting, Vienna
  • Place of Presentation: Austria
• [Presentation] Bio-inspired Catalists with Vitamin B12 Enzyme Functions (2009)
  • Author(s): Hisaeda, Y.
  • Organizer: 14th International Conference on Biological Inorganic Chemistry (ICBIC 14)
  • Place of Presentation: Nagoya
• [Presentation] Molecular Transformations Catalyzed by Vitamin B12-TiO_2 Hybrid Catalvs (2008)
  • Author(s): Y. Hisaeda
  • Organizer: The 9th International Symposium on Organic Reactions
  • Place of Presentation: Chiayi, Taiwan
  • Year and Date: 2008-11-21
• [Presentation] バイオインスパイアード触媒の創製と機能 (2008)
  • Author(s): 久枝良雄
  • Organizer: 九州錯体化学懇談会創設40周年記念シンポジウム
  • Place of Presentation: 福岡
  • Year and Date: 2008-11-01
• [Presentation] Redox Behavior and Photochemical Properties of Molybdenum Porphycene Complex (2008)
  • Author(s): Y. Hisaeda
  • Organizer: 213th Meeting of The Electrochemical Society
  • Place of Presentation: Phoenix, USA
  • Year and Date: 2008-05-20
• [Presentation] Catalytic Materials with Vitamin B12 Enzyme Functions (2008)
  • Author(s): Hisaeda, Y.
  • Organizer: The IUMRS International Conference in Asia 2008
  • Place of Presentation: Nagoya, Japan
• [Presentation] Molecular Transformations Catalyzed by Vitamin B12-TiO2 Hybrid Catalyst (2008)
  • Author(s): Hisaeda, Y.
  • Organizer: The 9th International Symposium on Organic Reactions
  • Place of Presentation: Chiayi, Taiwan
• [Presentation] Hybrid Nano-catalyst with Vitamin B12 Functions (2008)
  • Author(s): Hisaeda, Y.
  • Organizer: The 4th Asian Bioligical Inorganic Chemistry Conference
  • Place of Presentation: Jeju, Korea
• [Presentation] Bioinspired Catalysts Learned from Vitamin B12 Enzyme (2008)
  • Author(s): Hisaeda, Y.
  • Organizer: 1st Kyushu University CNSI/UCLA Joint Symposium, Los Angels
  • Place of Presentation: USA, January
• [Presentation] Catalytic Materials with Vitamin B12 Enzyme Functions(招待講演) (2008)
  • Author(s): Y. Hisaeda
  • Organizer: The IUMRS International Conference in Asia 2008
  • Place of Presentation: Nagoya, Japan
• [Presentation] Molecular Transformations Catalyzed by Vitamin B12-TiO2 Hybrid Catalyst(招待講演) (2008)
  • Author(s): Y. Hisaeda
  • Organizer: The 9th International Symposium on Organic Reactions
  • Place of Presentation: Chiayi, Taiwan
• [Presentation] Hybrid Nano-catalyst with Vitamin B12 Functions(招待講演) (2008)
  • Author(s): Y. Hisaeda
  • Organizer: The 4th Asian Bioligical Inorganic Chemistry Conference
  • Place of Presentation: Jeju, Korea
• [Presentation] Bioinspired Catalysts Learned from Vitamin B12 Enzyme(招待講演) (2008)
  • Author(s): Y. Hisaeda
  • Organizer: 1st Kyushu University CNSI/UCLA Joint Symposium
  • Place of Presentation: Los Angels, USA
• [Presentation] Bioinspired Catalysts Learned from Vitamin B12 Enzyme (2008)
  • Author(s): Y, Hisaeda
  • Organizer: 1st Kyushu University CNSI/UCLA Joint Symposium
  • Place of Presentation: Los Angels, USA
• [Presentation] Photochemical Reduction of Molybdenum Porphycene (2007)
  • Author(s): Hisaeda, Y.
  • Organizer: 2007 Korea-Japan Symposium on Frontier Photoscience
  • Place of Presentation: Gyeongju, Korea
• [Presentation] Sol-Gel Modified Electrode Trapped with a Cobalamin Derivative (2007)
  • Author(s): Hisaeda, Y.
  • Organizer: 211th Meeting of The Electrochemical Society
  • Place of Presentation: Chicago, USA
• [Presentation] Organic/Inorganic Hybrid Catalyst Learned from Vitamin B12 Enzyme (2007)
  • Author(s): Hisaeda, Y.
  • Organizer: Kyushu University 21COE/POSTECH 1st Joint Symposium on "Molecular Systems and Molecular Informatics", Fukuoka
  • Place of Presentation: Fukuoka, February
• [Presentation] Photochemical Reduction of Molybdenum Porphycene(招待講演) (2007)
  • Author(s): Y. Hisaeda
  • Organizer: Korea-Japan Symposium on Frontier Photoscience
  • Place of Presentation: Gyeongju, Korea
• [Book] Handbook of Porphyrin Science.(Bioinspired Catalysts with B_<12> Enzyme Functions, 10,Chapter 48) (2010)
  • Author(s): Hisaeda Y., Shimakoshi H.
• [Book] 有機ハロゲン化合物を分解する生体関連触媒の開発(有機物の分解とそのメカニズム・分析, 第1章第14節) (2007)
  • Author(s): 久枝良雄, 嶌越恒
  • Publisher: 情報機構
• [Book] 有機ハロゲン化合物を分解する生体関連触媒の開発, ,有機物の分解とそのメカニズム・分析, 第1章 第14 節, 情報機構 (2007)
  • Author(s): 久枝良雄, 嶌越恒
• [Book] 有機物の分解とそのメカニズム・分析 (2007)
  • Author(s): 久枝良雄
  • Total Pages: 14
  • Publisher: 情報機構
• [Book] モレキュラーインフォーマティクスを拓く分子機能材料 (2006)
  • Author(s): 久枝良雄
  • Total Pages: 9
  • Publisher: 日刊工業新聞
• [Remarks]
  • URL: http://www.cstm.kyushu-u.ac.jp/hisaeda/
• [Remarks] 研究成果が以下のように新聞により記事となり報道された。
• [Remarks] (1) 久枝良雄, 西日本新聞 朝刊, 2006 年4月19 日,「ハイブリッドナノ触媒」研究最前線〜さまざまな組み合わせを模索し、革新的触媒の開発へ〜
• [Remarks] (2) 久枝良雄, 読売新聞 朝刊, 2006 年4 月25 日, 新規触媒の開発 バイオインスパイアード触媒
• [Remarks] (3) 久枝良雄, 日本経済新聞 朝刊, 2007 年4 月16 日,ビタミンB12 光触媒と融合 九大