Molecular basis for emotion and its role in higher brain functions and psychiatric and neurological disorders

• Project/Area Number: 18100003
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Neuroscience in general
• Research Institution: The University of Tokyo
• Principal Investigator: MANABE Toshiya The University of Tokyo, 医科学研究所, 教授 (70251212)
• Project Period (FY): 2006 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥109,460,000 (Direct Cost: ¥84,200,000、Indirect Cost: ¥25,260,000); Fiscal Year 2010: ¥20,670,000 (Direct Cost: ¥15,900,000、Indirect Cost: ¥4,770,000); Fiscal Year 2009: ¥20,150,000 (Direct Cost: ¥15,500,000、Indirect Cost: ¥4,650,000); Fiscal Year 2008: ¥20,800,000 (Direct Cost: ¥16,000,000、Indirect Cost: ¥4,800,000); Fiscal Year 2007: ¥21,450,000 (Direct Cost: ¥16,500,000、Indirect Cost: ¥4,950,000); Fiscal Year 2006: ¥26,390,000 (Direct Cost: ¥20,300,000、Indirect Cost: ¥6,090,000)
• Keywords: 情動 / NMDA受容体 / 精神神経疾患 / 遺伝子改変マウス / 扁桃体 / 海馬 / シナプス可塑性 / リン酸化 / 線条体 / グルタミン酸受容体 / 長期増強 / マウス / シナプス伝達 / うつ病 / 電気生理学 / 脳・神経 / 脳神経疾患 / 行動学 / 遺伝子 / 生理学 / シナブス伝達

Research Abstract

In order to elucidate molecular mechanisms for emotion, we performed functional analyses mainly using gene-manipulated mice. We unraveled the roles of NMDA receptors, a kind of glutamate receptors, and physiologically active substances such as neuropeptides, acetylcholine and corticotropin-releasing factor expressed in the amygdala and hippocampus in synaptic transmission and plasticity as well as higher brain functions. We also discovered a novel type of synaptic plasticity. Furthermore, we elucidated precise mechanisms for inhibitory regulation of synaptic plasticity in the dentate gyrus.

Research Products

• [Journal Article] Age-dependent regulation of depression-like behaviors through modulation of adrenergic receptor α1A subtype expression revealed by the analysis of IL-1Ra knockout mice. (2011)
  • Author(s): Wakabayashi, C., Kiyama, Y., Manabe, T., Iwakura, Y.
  • Journal Title: Neuroscience (in press)
• [Journal Article] The mechanisms of the strong inhibitory modulation of long-term potentiation in the rat dentate gyrus. (2011)
  • Author(s): Arima-Yoshida, F., Watabe, A.M., Manabe, T.
  • Journal Title: Eur.J.Neurosci. 33 Pages: 1637-1646
• [Journal Article] The mechanisms of the strong inhibitory modulation of long-term potentiation in the rat dentate gyrus (2011)
  • Author(s): Arima-Yoshida, F., et al.
  • Journal Title: European Journal of Neuroscience Volume: (印刷中)(掲載確定)
  • Peer Reviewed
• [Journal Article] NMDAR2B tyrosine phosphorylation regulates anxiety-like behavior and CRF expression in the amygdala. (2010)
  • Author(s): Delawary, M., Tezuka, T., Kiyama, Y., Yokoyama, K., Inoue, T., Hattori S., Hashimoto R., Umemori, H., Manabe, T., Yamamoto, T., Nakazawa, T.
  • Journal Title: Mol.Brain 3 Pages: 37-37
• [Journal Article] NMDAR2B tyrosine phosphorylation regulates anxiety-like behavior and CRF expression in the amygdala (2010)
  • Author(s): Delawary, M., et al.
  • Journal Title: Molecular Brain Volume: 3 Pages: 37-37
  • Peer Reviewed
• [Journal Article] Ablation of NMDA receptors enhances the excitability of hippocampal CA3 neurons. (2009)
  • Author(s): Fukushima, F., Nakao, K., Shinoe, T., Fukaya, M., Marumatsu, S.-i., Sakimura, K., Kataoka, H., Mori, H., Watanabe, M, Manabe, T., Mishina, M.
  • Journal Title: PLoS ONE 4
• [Journal Article] Requirement of the immediate early gene vesl-1S/homer-1a for fear memory formation. (2009)
  • Author(s): Inoue, N., Nakao, H., Migishima, R., Hino, T., Matsui, M., Hayashi, F., Nakao, K., Manabe, T., Aiba, A., Inokuchi, K.
  • Journal Title: Mol.Brain 2 Pages: 7-7
• [Journal Article] Kinase-dead knock-in mouse reveals an essential role of Ca^<2+>/calmodulin-dependent protein kinase IIα kinase activity in dendritic spine enlargement (2009)
  • Author(s): Yamagata, Y., Kobayashi, S., Umeda, T., Inoue, A., Sakagami, H., Fukaya, M., Watanabe, M., Hatanaka, N., Totsuka, M., Yagi, T., Obata, K., Imoto, K., Yanagawa, Y., Manabe, T., Okabe, S.
  • Journal Title: LTP and learning. J.Neurosci. 29 Pages: 7607-7618
• [Journal Article] Non-Hebbian synaptic plasticity induced by repetitive postsynaptic action potentials. (2009)
  • Author(s): Kato, H.K., Watabe, A.M., Manabe, T.
  • Journal Title: J.Neurosci. 29 Pages: 11153-11160
• [Journal Article] Involvement of NMDAR2A tyrosine phosphorylation in depression-related behavior. (2009)
  • Author(s): Taniguchi, S., Nakazawa, T., Tanimura, A., Kiyama, Y., Tezuka, T., Watabe, A.M., Katayama, N., Yokoyama, K., Inoue, T., Izumi-Nakaseko, H., Kakuta, S., Sudo, K., Iwakura, Y., Umemori, H., Inoue, T., Murphy, N.P., Hashimoto, K., Kano, M., Manabe, T., Yamamoto, T.
  • Journal Title: EMBO J. 28 Pages: 3717-3729
• [Journal Article] Ablation of NMDA receptors enhances the excitability of hippocampal CA3 neurons (2009)
  • Author(s): Fukushima F., et al.
  • Journal Title: PLoS ONE 4
  • Peer Reviewed
• [Journal Article] Requirement of the immediate early gene vesl-1S/homer-1a for fear memory formation (2009)
  • Author(s): Inoue N., et al.
  • Journal Title: Molecular Brain 2 Pages: 7-7
  • Peer Reviewed
• [Journal Article] Kinase-dead knock-in mouse reveals an essential role of Ca^<2+>/calmodulin-dependent protein kinase IIα kinase activity in dendritic spine enlargement, LTP and leraning (2009)
  • Author(s): Yamagata Y., et al.
  • Journal Title: Journal of Neuroscience 29 Pages: 7607-7618
  • Peer Reviewed
• [Journal Article] Non-Hebbian synaptic plasticity induced by repetitive postsynaptic action potentials (2009)
  • Author(s): Kato H.K., et al.
  • Journal Title: Journal of Neuroscience 29 Pages: 11153-11160
  • Peer Reviewed
• [Journal Article] Involvement of NMDAR2A tyrosine phosphorylation in depression-related behavior (2009)
  • Author(s): Taniguchi S., et al.
  • Journal Title: EMBO Journal 28 Pages: 3717-3729
  • Peer Reviewed
• [Journal Article] Requirement of the immediate early gene vesl-1 S/homer-lafor fear memory formation (2009)
  • Author(s): Inoue, N. et al
  • Journal Title: Mol. Brain 2 Pages: 7-7
  • Peer Reviewed
• [Journal Article] Ablation of NMDA receptors enhances the excitability of hippocampal CA3 meurons (2009)
  • Author(s): Fukushima, F. et al.
  • Journal Title: PloS ONE 4
  • Peer Reviewed
• [Journal Article] Functional contributions of synaptically localized NR2B subunits of the NMDA receptor to synaptic transmission and LTP induction in the adult mouse CNS. (2008)
  • Author(s): Miwa, H., Fukaya, M., Watabe, A.M., Watanabe, M., Manabe, T.
  • Journal Title: J.Physiol.(Lond.) 586 Pages: 2539-2550
• [Journal Article] Use-dependent amplification of presynaptic Ca^<2+> signaling by axonal ryanodine receptors at the hippocampal mossy fiber synapse. (2008)
  • Author(s): Shimizu, H., Fukaya, M., Yamasaki, M., Watanabe, M., Manabe, T., Kamiya, H.
  • Journal Title: Proc.Natl.Acad.Sci.USA 105 Pages: 11998-12003
• [Journal Article] Dual inhibition of SNARE complex formation by tomosyn ensures controlled neurotransmitter release. (2008)
  • Author(s): Sakisaka, T., Yamamoto, Y., Mochida, S., Nakamura, M., Nishikawa, K., Ishizaki, H., Okamoto-Tanaka, M., Miyoshi, J., Fujiyoshi, Y., Manabe, T., Takai, Y.
  • Journal Title: J.Cell Biol. 183 Pages: 323-337
• [Journal Article] Functional contributions of synaptically localized NR2B subunits of the NMDA receptor to synaptic transmission and LTP induction in the adult mouse CNS (2008)
  • Author(s): Miwa, H., Fukaya, M., Watabe, A. M., Watanabe, M.and Manabe, T.
  • Journal Title: J. Physiol.(Lond.) 586(peer reviewed) Pages: 2539-2550
• [Journal Article] Use-dependent amplification of presynaptic Ca^(2+) signaling by axonal ryanodine receptors at the hippocampal mossy fiber synapse (2008)
  • Author(s): Shimizu H., Fukaya, M., Yamasaki, M., Watanabe, M., Manabe, T.and Kamiya, H.
  • Journal Title: Proc. Natl. Acad.Sci. USA 105(peer reviewed) Pages: 11998-12003
• [Journal Article] Dual inhibition of SNARE complex formation by tomosyn ensures controlled neurotransmitter (2008)
  • Author(s): Sakisaka, T. et al.
  • Journal Title: J, Cell Biol. 183 Pages: 323-337
  • Peer Reviewed
• [Journal Article] Use-dependent amplification of presynaptic Ca signaling by axonal ryanodine receptors at the hippocampal mossy fiber (2008)
  • Author(s): Shimizu H. et al.
  • Journal Title: Proc. Natl. Acad. Sci. USA 105 Pages: 11998-12003
  • Peer Reviewed
• [Journal Article] Functional contributions of synaptically localized NR2B subunits of the NMDA receptor to synaptic transmission and LTP induction in the adult mouse CNS (2008)
  • Author(s): Miwa, H., et. al.
  • Journal Title: Journal of Physiology 掲載確定(印刷中)
  • Peer Reviewed
• [Journal Article] Upregulated PAR-2-mediated salivary secretion in mice deficient in muscarinic acetylcholine receptor subtypes. (2007)
  • Author(s): Nishiyama, T., Nakamura, T., Obara, K., Inoue, H., Mishima, K., Matsumoto, N., Matsui, M., Manabe, T., Mikoshiba, K., Saito, I.
  • Journal Title: J.Pharmacol.Exp.Ther. 320 Pages: 516-524
• [Journal Article] Tonic enhancement of endocannabinoid-mediated retrograde suppression of inhibition by cholinergic interneuron activity in the striatum. (2007)
  • Author(s): Narushima, M., Uchigashima, M., Fukaya, M., Matsui, M., Manabe, T., Hashimoto, K., Watanabe, M., Kano, M.
  • Journal Title: J.Neurosci. 27 Pages: 496-506
• [Journal Article] GABAergic interneurons facilitate mossy fiber excitability in the developing hippocampus. (2007)
  • Author(s): Nakamura, M., Sekino, Y., Manabe, T.
  • Journal Title: J.Neurosci. 27 Pages: 1365-1373
• [Journal Article] Interactions between plexin-A2, plexin-A4 and semaphorin 6A control lamina-restricted projection of hippocampal mossy fibers. (2007)
  • Author(s): Suto, F., Tsuboi, M., Kamiya, H., Mizuno, H., Kiyama, Y., Komai, S., Shimizu, M., Sanbo, M., Yagi, T., Hiromi, Y., Chedotal, A., Mitchell, K.J., Manabe, T., Fujisawa, H.
  • Journal Title: Neuron 53 Pages: 535-547
• [Journal Article] The neuropeptide nociceptin is a synaptically released endogenous inhibitor of hippocampal long-term potentiation. (2007)
  • Author(s): Bongsebandhu-phubhakdi, S., Manabe, T.
  • Journal Title: J.Neurosci. 27 Pages: 4850-4858
• [Journal Article] Involvement of protein-tyrosine phosphatase PTPMEG in motor learning and cerebellar long-term depression. (2007)
  • Author(s): Kina, S.-i., Tezuka, T., Kusakawa, S., Kishimoto, Y., Kakizawa, S., Hashimoto, K., Ohsugi, M., Kiyama, Y., Horai, R., Sudo, K., Kakuta, S., Iwakura, Y., Iino, M., Kano, M., Manabe, T., Yamamoto, T.
  • Journal Title: Eur.J.Neurosci. 26 Pages: 2269-2278
• [Journal Article] GABAergic interneurons facilitate mossy fiber excitability in the developing hippocampus (2007)
  • Author(s): Nakamura, M., Sekino, Y.and Manabe, T.
  • Journal Title: J. Neurosci 27(peer reviewed) Pages: 1365-1373
• [Journal Article] The neuropeptide nociceptin is a synaptically released endogenous inhibitor of hippocampal long-term potentiation (2007)
  • Author(s): Bongsebandhu-phubhakdi, S.and Manabe,T.
  • Journal Title: J.Neurosci 27(peer reviewed) Pages: 4850-4858
• [Journal Article] The neuropeptide nociceptin is a synaptically released endogenous inhibitor of hippocampal long-term potentiation (2007)
  • Author(s): Bongsebandhu-phubhakdi, S., et. al.
  • Journal Title: Journal of Neuroscience 27 Pages: 4850-4858
  • Peer Reviewed
• [Journal Article] Involvement of protein-tyrosine phosphatase PTPMEG in motor learning and cerebellar long-term depression (2007)
  • Author(s): Kina, S.-i., et. al.
  • Journal Title: European Journal of Neuroscience 26 Pages: 2269-2278
  • Peer Reviewed
• [Journal Article] GABAergic interneurons facilitate mossy fiber excitability in the developing hippocampus (2007)
  • Author(s): Nakamura, M., Sekino, Y. and Manabe, T.
  • Journal Title: Journal of Neuroscience 27 Pages: 1365-1373
• [Journal Article] Tonic enhancement of endocannabinoid-mediated retrograde suppression of inhibition by cholinergic interneuron activity in the striatum (2007)
  • Author(s): Narushima, M., Uchigashima, M., Fukaya, M., Matsui, M., Manabe, T., Hashimoto, K., Watanabe, M. and Kano, M.
  • Journal Title: Journal of Neuroscience 27 Pages: 496-506
• [Journal Article] Upregulated PAR-2-mediated salivary secretion in mice deficient in muscarinic acetylcholine receptor subtypes (2007)
  • Author(s): Nishiyama, T., Nakamura, T., Obara, K., Inoue, H., Mishima, K., Matsumoto, N., Matsui, M., Manabe, T., Mikoshiba, K. and Saito, I.
  • Journal Title: Journal of Pharmacology and Experimental Therapeutics 320 Pages: 516-524
• [Journal Article] Interactions between plexin-A2, plexin-A4 and semaphorin 6A control lamina-restricted projection of hippocampal mossy fibers (2007)
  • Author(s): Suto, F., Tsuboi, M., Kamiya, H., Mizuno, H., Kiyama, Y., Komai, S., Shimizu, M., Sanbo, M., Yagi, T., Hiromi, Y., Chedotal, A., Mitchell, K. J., Manabe, T. and Fujisawa, H.
  • Journal Title: Neuron 53 Pages: 535-547
• [Journal Article] The neuropeptide nociceptin is a synaptically released endogenous inhibitor of hippocampal long-term potentiation (2007)
  • Author(s): Bongsebandhu-phubhakdi, S. and Manabe, T.
  • Journal Title: Journal of Neuroscience 27 Pages: 4850-4858
• [Journal Article] Involvement of protein-tyrosine phosphatase PTPMEG in motor learning and cerebellar long-term depression (2007)
  • Author(s): Kina, S.-i., Tezuka, T., Kusakawa, S., Kishimoto, Y., Kakizawa, S., Hashimoto, K., Ohsugi, M., Kiyama, Y., Horai, Sudo, K., Kakuta, S., Iwakura, Y., Iino, M., Kano, M., Manabe, T. and Yamamoto, T.
  • Journal Title: Eur. J. Neurosci. 26 Pages: 2269-2278
• [Journal Article] Involvement of nectins in the formation of puncta adherentia junctions and the mossy fiber trajectory in the mouse hippocampus. (2006)
  • Author(s): Honda, T., Sakisaka, T., Yamada, T., Kumazawa, N., Hoshino, T., Kajita, M., Kayahara, T., Ishizaki, H., Tanaka-Okamoto, M., Mizoguchi, A., Manabe, T., Miyoshi, J., Takai, Y.
  • Journal Title: Mol.Cell.Neurosci. 31 Pages: 315-325
• [Journal Article] NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity. (2006)
  • Author(s): Nakazawa, T., Komai, S., Watabe, A.M., Kiyama, Y., Fukaya, M., Arima-Yoshida, F., Horai, R., Sudo, K., Ebine, K., Delawary, M., Goto, J., Umemori, H., Tezuka, T., Iwakura, Y., Watanabe, M., Yamamoto, T., Manabe, T.
  • Journal Title: EMBO J. 25 Pages: 2867-2877
• [Journal Article] NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity (2006)
  • Author(s): Nakazawa, T., Komai, S., Watabe, A. M.,Kiyama, Y., Fukaya, M.,Arima-Yoshida,F., Horai, R., Sudo, K., Ebine, K., Delawary, M., Goto, J., Umemori, H., Tezuka, T., Iwakura, Y., Watanabe, M., Yamamoto, T.and Manabe, T.
  • Journal Title: EMBO J. 25(peer reviewed) Pages: 2867-2877
• [Journal Article] NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity (2006)
  • Author(s): Nakazawa, T., Komai, S., Watabe, A. M., Kiyama, Y., Fukaya, M., Arima-Yoshida, F., Horai, R., Sudo, K., Ebine, K., Delawary, M., Goto, J., Umemori, H., Tezuka, T., Iwakura, Y., Watanabe, M., Yamamoto, T. and Manabe, T.
  • Journal Title: EMBO Journal 25 Pages: 2867-2877
• [Journal Article] Functional contributions of synatically localized NR2B subunits of the NMDA recept to synaptic transmission and LTP induction in the adult mouse CNS
  • Author(s): Miwa, H. et al.
  • Journal Title: J. Physiol.(Lond.)
• [Presentation] Memory System - The role of CaMKII and calcium channels in synaptic plasticity and higher brain functions- (2010)
  • Author(s): Manabe, T.
  • Organizer: RIKEN BSI Tutorial Series 2010
  • Place of Presentation: 和光市
  • Year and Date: 2010-12-07
• [Presentation] Memory System-The role of CaMKII and calcium channels in synaptic plasticity and higher brain functions- (2010)
  • Author(s): Manabe, T.
  • Organizer: RIKEN BSI Tutorial Series 2010
  • Place of Presentation: 理化学研究所脳科学総合研究センター(埼玉県)
  • Year and Date: 2010-12-07
• [Presentation] 情動を制御する分子機構 (2010)
  • Author(s): 真鍋俊也
  • Organizer: 京都大学霊長類研究所共同利用研究会「社会・報酬・経済と脳」
  • Place of Presentation: 京都大学霊長類研究所(愛知県)
  • Year and Date: 2010-11-01
• [Presentation] シナプス可塑性と高次脳機能の分子機構 (2010)
  • Author(s): 真鍋俊也
  • Organizer: 福島県立医科大学生体情報伝達研究所セミナー
  • Place of Presentation: 福島県立医科大学(福島県)
  • Year and Date: 2010-10-06
• [Presentation] The replacement of GluN2B with GluN2A increases synaptic trafficking of AMPA receptors in the neonatal mouse brain. (2010)
  • Author(s): Hamada, S., Ogawa, I., Kiyama, Y., Watabe, A.M., Kassai, H., Nakao, K., Aiba, A., Manabe, T.
  • Organizer: Japan Neuroscience Society, Annual Meeting
  • Place of Presentation: 神戸市
  • Year and Date: 2010-09-03
• [Presentation] The replacement of GluN2B with GluN2A increases synaptic trafficking of AMPA receptors in the neonatal mouse brain (2010)
  • Author(s): Hamada, S., et al.
  • Organizer: Japan Neuroscience Society, Annual Meeting
  • Place of Presentation: 神戸コンベンションセンター(兵庫県)
  • Year and Date: 2010-09-03
• [Presentation] Involvement of GluN2A tyrosine phosphorylation in depression-related behavior (2010)
  • Author(s): Nakazawa, T., et al.
  • Organizer: Federation of European Neuroscience Societies, Annual Meeting
  • Place of Presentation: Amsterdam, Holland
  • Year and Date: 2010-07-05
• [Presentation] NMDA受容体のリン酸化による高次脳機能制御機構 (2010)
  • Author(s): 真鍋俊也
  • Organizer: 神戸大学大学院セミナー
  • Place of Presentation: 神戸大学大学院医学系研究科(兵庫県)
  • Year and Date: 2010-06-14
• [Presentation] Cholinergic suppression of synaptic transmission in the lateral amygdale. (2010)
  • Author(s): Tazuke, C., Miwa, H., Matsui, M., Watabe, A.M., Manabe, T.
  • Organizer: The Physiological Society of Japan, The 87th Annual Meeting
  • Place of Presentation: 盛岡市
  • Year and Date: 2010-05-20
• [Presentation] Involvement of NMDAR2A tyrosine phosphorylation in depression-related behavior (2009)
  • Author(s): Nakazawa T., et al.
  • Organizer: 日本分子生物学会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-09
• [Presentation] Cholinergic suppression of synaptic transmission in the lateral amygdala (2009)
  • Author(s): Tazuke C., et al.
  • Organizer: 日本神経科学学会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-11-17
• [Presentation] Kinase activity of CaMKIIα is essential for structural, functional and behavioral expression of synaptic memory (2009)
  • Author(s): Yamagata Y., et al.
  • Organizer: 日本神経科学学会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-11-17
• [Presentation] The role of L-type voltage-dependent calcium channels in hippocampal synaptic plasticity. (2009)
  • Author(s): Manabe, T.
  • Organizer: The 3rd Japan-Korea Neuroscience Symposium "Cutting Edge of Neuroscience"
  • Place of Presentation: Busan, South Korea
  • Year and Date: 2009-08-26
• [Presentation] The role of L-type voltage-dependent calcium channels in hippocampal synaptic plasticity (2009)
  • Author(s): Manabe T.
  • Organizer: 第3回日韓神経科学シンポジウム
  • Place of Presentation: 韓国・釜山
  • Year and Date: 2009-08-26
• [Presentation] Prolonged low-frequency stimulation induces mitochondria-dependent short-term potentiation at hippocampal CA3-CA1 synapses. (2009)
  • Author(s): Morimoto, T., Watabe, A.M., Manabe, T.
  • Organizer: International Congress of Physiological Sciences
  • Place of Presentation: 京都市
  • Year and Date: 2009-07-28
• [Presentation] Prolonged low-frequency stimulation induces mitochondria-dependent short-term potentiation at hippocampal CA3-CA1 synapses (2009)
  • Author(s): Morimoto T., et al.
  • Organizer: International Congress of Physiological Sciences
  • Place of Presentation: 京都
  • Year and Date: 2009-07-28
• [Presentation] The role of kinase activity of Ca^<2+>/calmodulin-dependent protein kinase II in hippocampal synaptic plasticity and learning (2009)
  • Author(s): Yamagata Y., et al.
  • Organizer: International Congress of Physiological Sciences
  • Place of Presentation: 京都
  • Year and Date: 2009-07-28
• [Presentation] シナプス可塑性におけるL型カルシウムチャネルの役割 (2009)
  • Author(s): 真鍋俊也
  • Organizer: 生理学研究所研究会
  • Place of Presentation: 岡崎
  • Year and Date: 2009-06-18
• [Presentation] The role of CaMKII and calcium channels in synaptic plasticity and higher brain functions (2009)
  • Author(s): Manabe T.
  • Organizer: CREST Neuroscience International Symposium
  • Place of Presentation: 淡路島
  • Year and Date: 2009-06-02
• [Presentation] Calcium influx through voltage-dependent calcium channels can induce non-Hebbian LTP in the CA1 region of the mouse hippocampus. (2008)
  • Author(s): Kato, H., Watabe, A.M., Manabe, T.
  • Organizer: Society for Neuroscience, Annual Meeting
  • Place of Presentation: Washington DC, U.S.A.
  • Year and Date: 2008-11-17
• [Presentation] Hippocampal long-term potentiation is inhibited by synaptically released endogenous nociceptin. (2008)
  • Author(s): Bongsebandhu-phubhakdi, S., Manabe, T.
  • Organizer: Society for Neuroscience, Annual Meeting
  • Place of Presentation: Washington DC, U.S.A.
  • Year and Date: 2008-11-17
• [Presentation] Hippocally long-potentiation is inhibited by synaptically released endogenous nociceptin (2008)
  • Author(s): Bongsebandhu-Phubhakdi, S. and Mamage T.
  • Organizer: Society for Neutoscience(USA)
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2008-11-17
• [Presentation] GABAergic modulation of mossy fiber excitability in the developing hippocampus. (2008)
  • Author(s): Manabe, T.
  • Organizer: Symposium "Molecular physiology of the presynaptic function" (Japan Neuroscience Society, Annual Meeting)
  • Place of Presentation: 東京
  • Year and Date: 2008-07-11
• [Presentation] Involvement of NR2A tyrosine phosphorylation in depression-related behaviors. (2008)
  • Author(s): Tezuka, T., Taniguchi, S., Nakazawa, T., Kiyama, Y., Manabe, T., Yamamoto, T.
  • Organizer: Japan Neuroscience Society, Annual Meeting
  • Place of Presentation: 東京
  • Year and Date: 2008-07-11
• [Presentation] GABAergic modulation of mossy fiber excitability in the developing hippocampus. Symposium "Molecular physiology of the presynaptic function (2008)
  • Author(s): Manabe, T.
  • Organizer: Japan Neuroscience Society
  • Place of Presentation: 東京
  • Year and Date: 2008-07-11
• [Presentation] Synaptic vesicle pool size affects the frequency dependency of synaptic transmission in the hippocampus (2008)
  • Author(s): Fukushima, A., Sekino, Y., Manabe, T.
  • Organizer: Japan Neuroscience Society, Annual Meeting
  • Place of Presentation: 東京
  • Year and Date: 2008-07-09
• [Presentation] The role of tyrosine phosphorylation of the NMDA receptor in synaptic plasticity and higher brain functions. (2008)
  • Author(s): Manabe, T.
  • Organizer: The 36th SEIRIKEN Conference "Stock and Flow of functional molecules in synapse"
  • Place of Presentation: 岡崎市
• [Presentation] Molecular and cellular mechanisms for memory formation. (2007)
  • Author(s): Manabe, T.
  • Organizer: Konkuk International Symposium for Biomedical Sciences 2007
  • Place of Presentation: Seoul, South Korea
  • Year and Date: 2007-10-06
• [Presentation] Electrophysiological and behavioral analysis of gene-targeted mice to understand mechanisms of learning and memory. (2007)
  • Author(s): Kiyama, Y., Manabe, T.
  • Organizer: Symposium "Understanding Mechanisms of Learning and Memory from Molecule to Behavior" (Japan Neuroscience Society, Annual Meeting)
  • Place of Presentation: 横浜市
  • Year and Date: 2007-09-12
• [Presentation] The rleuropeptide nociceptin regulates hippocampal long-term potentiation(LTP)andmemory formation (2007)
  • Author(s): Manabe, T.
  • Organizer: 日本神経科学学会
  • Place of Presentation: 横浜
  • Year and Date: 2007-09-11
• [Presentation] Presynaptic short-term plasticity at the hippocampal mossy fiber synapse. (2007)
  • Author(s): Manabe, T.
  • Organizer: Symposium "Short-term plasticity and synaptic computation" (The 15th Federation Meeting of Korean Basic Medical Scientists)
  • Place of Presentation: Deajon, South Korea
  • Year and Date: 2007-04-26
• [Presentation] Functional properties of the NMDA receptor in the lateral amygdala : comparison with those in the hippocampal CA1 region. (2007)
  • Author(s): Miwa, H., Fukaya, M., Watabe, A., Watanabe, M., Manabe, T.
  • Organizer: Symposium "Cellular and molecular mechanism of synaptic plasticity" (The Physiological Society of Japan, The 84th Annual Meeting)
  • Place of Presentation: 大阪市
  • Year and Date: 2007-03-20
• [Presentation] The presynaptic TrkB receptor modulates an N-type Ca^<2+> channel-dependent component of post-tetanic potentiation. (2006)
  • Author(s): Kumazawa, N., Kato, E., Takeuchi, T., Watabe, A.M., Mishina, M., Manabe, T.
  • Organizer: Society for Neuroscience, Annual Meeting
  • Place of Presentation: Atlanta, U.S.A.
  • Year and Date: 2006-10-17
• [Presentation] Modulation of synaptic plasticity by physiological activation of M_1 muscarinic acetylcholine receptors. (2006)
  • Author(s): Shinoe, T., Matsui, M., Manabe, T.
  • Organizer: Society for Neuroscience, Annual Meeting
  • Place of Presentation: Atlanta, U.S.A.
  • Year and Date: 2006-10-16
• [Presentation] Inhibitory modulation of synaptic plasticity is stronger in the dentate gyrus than in the CA1 region of the hippocampus. (2006)
  • Author(s): Arima, F., Watabe, A.M., Manabe, T.
  • Organizer: Society for Neuroscience, Annual Meeting
  • Place of Presentation: Atlanta, U.S.A.
  • Year and Date: 2006-10-14
• [Presentation] Roles of NMDA receptor phosphorylation in the amygdala. (2006)
  • Author(s): Manabe, T.
  • Organizer: Symposium "Trafficking and localization of the NMDA receptor" at The Physiological Society of Japan, The 83rd Annual Meeting
  • Place of Presentation: 前橋市
  • Year and Date: 2006-05-28
• [Book] Clinical Neuroscience 29巻2号(長期増強・長期抑圧) (2011)
  • Author(s): 片桐大之、真鍋俊也
  • Publisher: 中外医学社
• [Book] 長期増強・長期抑圧 (2011)
  • Author(s): 片桐大之、真鍋俊也
  • Publisher: 中外医学社
• [Book] 脳科学と学習・教育(分子基盤からみた学習機構の生後発達)(小泉英明(編)) (2010)
  • Author(s): 真鍋俊也
  • Publisher: 明石書店
• [Book] Clinical Neuroscience 28巻8号(長期増強(LTP)) (2010)
  • Author(s): 真鍋俊也
  • Publisher: 中外医学社
• [Book] 長期増強(LTP) (2010)
  • Author(s): 真鍋俊也
  • Publisher: 中外医学社
• [Book] 脳科学と学習・教育 (2010)
  • Author(s): 真鍋俊也
  • Total Pages: 245
  • Publisher: 明石書店
• [Book] 蛋白質・核酸・酵素 53巻4号(海馬におけるシナプス可塑性の分子細胞機構 「神経の分化、回路形成、機能発現」)(三品昌美、山森哲雄、狩野方伸、村上富士夫、貝淵弘三(編)) (2008)
  • Author(s): 真鍋俊也
  • Publisher: 共立出版
• [Book] 生体の科学 59巻5号(長期増強「現代医学・生物学の仮説・学説2008」) (2008)
  • Author(s): 真鍋俊也
  • Publisher: 医学書院
• [Book] Brain and Nerve 60巻7号(記憶の分子メカニズム「学習と記憶-基礎と臨床」) (2008)
  • Author(s): 真鍋俊也
  • Publisher: 医学書院
• [Book] 分子・細胞・シナプスからみる脳(海馬におけるシナプス可塑性)(古市貞一(編)) (2008)
  • Author(s): 真鍋俊也
  • Publisher: 東京大学出版会
• [Book] Clinical Neuroscience 26巻4号(扁桃体シナプス長期増強と情動記憶の分子制御) (2008)
  • Author(s): 渡部文子、真鍋俊也
  • Publisher: 中外医学社
• [Book] Medical Briefs in Brain & Nerve 16巻4号(海馬歯状回およびCA3領域における外部情報のパターン分離) (2008)
  • Author(s): 真鍋俊也
  • Publisher: マッキャンヘルスケアーワールドワイドジャパン
• [Book] Encyclopedia of Neuroscience(Associative Long-Term Potentiation.)(edited by Binder, M.D., Hirokawa, N., Windhorst, U.) (2008)
  • Author(s): 真鍋俊也
  • Publisher: Springer
• [Book] Encyclopedia of Neuroscience(Long-Term Potentiation (LTP).)(edited by Binder, M.D., Hirokawa, N., Windhorst, U.) (2008)
  • Author(s): 真鍋俊也
  • Publisher: Springer
• [Book] Encyclopedia of Neuroscience(Memory, Molecular Mechanisms)(edited by Binder, M.D., Hirokawa, N., Windhorst, U.) (2008)
  • Author(s): 真鍋俊也
  • Publisher: Springer
• [Book] 分子・細胞・シナプスからみる脳 (2008)
  • Author(s): 真鍋俊也
  • Total Pages: 284
  • Publisher: 東京大学出版会
• [Book] 神経の分化、回路形成、機能発現 (2008)
  • Author(s): 真鍋俊也
  • Total Pages: 300
  • Publisher: 共立出版
• [Book] 神経の分化、回路形成、機能発現 (2008)
  • Author(s): 真鍋 俊也
  • Total Pages: 300
  • Publisher: 共立出版
• [Book] 中枢神経系におけるモジュレーション 58巻6号(Rhoキナーゼによる海馬LTPの変調 生体の科学 連載講座) (2007)
  • Author(s): 真鍋俊也
  • Publisher: 医学書院
• [Book] 脳神経科学イラストレイテッド 改訂第2版(シナプス可塑性(長期増強、長期抑圧、構造変化))(森寿、真鍋俊也、渡辺雅彦、岡野栄之、宮川剛(編)) (2006)
  • Author(s): 渡部文子、真鍋俊也
  • Publisher: 羊土社
• [Book] 実験医学増刊「脳機能研究の新展開」(扁桃体におけるシナプス可塑性と情動記憶の分子メカニズム)(狩野方伸、高田昌彦、伊佐正(編)) (2006)
  • Author(s): 真鍋俊也
  • Publisher: 羊土社
• [Book] 脳機能研究の新展開 (2006)
  • Author(s): 真鍋 俊也
  • Total Pages: 232
  • Publisher: 羊土社
• [Remarks] ホームページ
  • URL: http://www.ims.u-tokyo.ac.jp/NeuronalNetwork/Neuronal_Network/Index.html
• [Remarks]
  • URL: http://www.ims.u-tokyo.ac.jp/NeuronalNetwork/Neuronal_Network/Index_japanese.htm
• [Remarks]
  • URL: http://www.ims.u-tokyo.ac.jp/NeuronalNetwork/Neuronal_Network/Index_japanese.htm
• [Remarks]
  • URL: http://www.ims.u-tokyo.ac.jp/NeuronalNetwork/Neuronal_Network/Index_japanese.htm
• [Remarks] Sakisaka et.al. Dual inhibition of SNARE complex formation by tomosyn ensures complex formation by tomosyn ensures controlled neurotransmitter release. J. Cell Biol. 183 : 323-337, 2008(F1000 Factor 6.0; October 28, 2008)
  • URL: http://www.f1000biology.com/guardpages/evaluation/1124834//article/article.asp%253Fid%253D1124834%2526view%253D%2526style%253D
• [Remarks] Nakazawa et.al. NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity.EMBO J. 25 : 2867-2877, 2006.(F1000 Factor 6.0 ; June 1, 2006)
  • URL: http://www.f1000biology.com/guardpages/evaluation/1032493//article/article.asp%253Fid%253D1032493%2526view%253D%2526style%253D
• [Remarks]
  • URL: http://www.ims.u-tokyo.ac.jp/NeutonlNetwork/Neuronal_Network/Index_japanese.htm