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Explorations into development of bionic baroreflex system to overcome arterial pressure dysregulation in patients with cervical cord injury

Research Project

Project/Area Number 18100006
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Biomedical engineering/Biological material science
Research InstitutionKyushu University

Principal Investigator

SUNAGAWA Kenji  Kyushu University, 医学研究院, 教授 (50163043)

Co-Investigator(Kenkyū-buntansha) HIROOKA Yoshitaka  九州大学, 大学病院, 講師 (90284497)
TODAKA Koji  九州大学, 大学病院, 特任准教授 (40398061)
CHISYAKI Akiko  九州大学, 医学研究院, 教授 (60216497)
川田 徹  国立循環器病センター研究所, 循環動態機能部, 室長 (30243752)
Co-Investigator(Renkei-kenkyūsha) KAWADA Toru  国立循環器病研究センター, 研究所, 室長 (30243752)
Project Period (FY) 2006 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥110,110,000 (Direct Cost: ¥84,700,000、Indirect Cost: ¥25,410,000)
Fiscal Year 2010: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
Fiscal Year 2009: ¥21,580,000 (Direct Cost: ¥16,600,000、Indirect Cost: ¥4,980,000)
Fiscal Year 2008: ¥21,580,000 (Direct Cost: ¥16,600,000、Indirect Cost: ¥4,980,000)
Fiscal Year 2007: ¥21,580,000 (Direct Cost: ¥16,600,000、Indirect Cost: ¥4,980,000)
Fiscal Year 2006: ¥34,580,000 (Direct Cost: ¥26,600,000、Indirect Cost: ¥7,980,000)
Keywordsバイオニック医学 / 血圧制御 / 脊髄損傷 / 自動治療 / 生体医工学
Research Abstract

Central baroreflex failure in spinal cord injuries results in serious orthostatic hypotension. Even the latest medical science fails to provide a fundamental remedy for those patients. Since somatic inputs affect sympathetic activities, we examined if transcutaneous electrical stimulation can feedback control arterial pressure (bionic baroreflex system) in spinalized patients. We identified skin regions capable of increasing arterial pressure in response to electrical stimulation. We then determined the transfer function from the stimulation to arterial pressure responses and developed the bionic baroreflex system. The bionic baroreflex system fully prevented orthostatic hypotension in patients with spinal cord injuries.

Report

(7 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report   Self-evaluation Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (225 results)

All 2011 2010 2009 2008 2007 2006 Other

All Journal Article (97 results) (of which Peer Reviewed: 75 results) Presentation (115 results) Remarks (2 results) Patent(Industrial Property Rights) (11 results) (of which Overseas: 6 results)

  • [Journal Article] Peak systolic mitral annulus velocity reflects the status of entricular-arterial coupling-theoretical and experimental analyses.2011

    • Author(s)
      Uemura K, Kawada T, Sunagawa K, Sugimachi M.
    • Journal Title

      J Am Soc Echocardiogr. 24

      Pages: 582-591

    • Related Report
      2010 Final Research Report
  • [Journal Article] Imbalance of central nitric oxide and reactive oxygen species in the regulation of sympathetic activity and neural mechanisms of hypertension.2011

    • Author(s)
      Hirooka Y, Kishi T, Sakai K, Takeshita A, Sunagawa K.
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol. 300

    • Related Report
      2010 Final Research Report
  • [Journal Article] Imbalance of central nitric oxide and reactive oxygen species in the regulation of sympathetic activity and neural mechanisms of hypertension2011

    • Author(s)
      Hirooka Y, et al
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol.

      Volume: 300

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nanoparticle-mediated delivery of pitavastatin into lungs ameliorates the development and induces regression of monocrotaline-induced pulmonary artery hypertension.2011

    • Author(s)
      Chen L, et al
    • Journal Title

      Hypertension

      Volume: 57 Pages: 343-350

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A case of multiple focal nodular hyperplasia in the liver which developed after heart transplantation.2011

    • Author(s)
      Fujino T, et al
    • Journal Title

      Intern Med.

      Volume: 50 Pages: 43-46

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Baroreflex sensitivity might predict responders to milrinone in patients with heart failure.2010

    • Author(s)
      Kishi T, Sunagawa K.
    • Journal Title

      Int Heart J. 51

      Pages: 411-415

    • Related Report
      2010 Final Research Report
  • [Journal Article] Blockade of mineralocorticoid receptors improves salt-induced left-ventricular systolic dysfunction through attenuation of enhanced sympathetic drive in mice with pressure overload.2010

    • Author(s)
      Ito K, Hirooka Y, Sunagawa K.
    • Journal Title

      J Hypertens. 28

      Pages: 1449-1458

    • Related Report
      2010 Final Research Report
  • [Journal Article] Angiotensin II type 1 receptor-activated caspase-3 through ras/mitogen-activated protein kinase/extracellular signal-regulated kinase in the rostral ventrolateral medulla is involved in sympathoexcitation in stroke-prone spontaneously hypertensive rats.2010

    • Author(s)
      Kishi T, Hirooka Y, Konno S, Ogawa K, Sunagawa K.
    • Journal Title

      Hypertension. 55

      Pages: 291-297

    • Related Report
      2010 Final Research Report
  • [Journal Article] Baroreflex sensitivity might predict responders to milrinone in patients with heart failure.2010

    • Author(s)
      Kishi T, Sunagawa K.
    • Journal Title

      Int Heart J

      Volume: 51 Pages: 411-415

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Para-Hisian pacing for a pediatric patient with a congenitally corrected transposition of the great arteries (SLL).2010

    • Author(s)
      Takemoto M, et al
    • Journal Title

      Pacing Clin Electrophysiol.

      Volume: 33

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sympathoinhibition induced by centrally administered atorvastatin is associated with alteration of NAD(P)H and Mn superoxide dismutase activity in rostral ventrolateral medulla of stroke-prone spontaneously hypertensive rats.2010

    • Author(s)
      Kishi T, et al
    • Journal Title

      J Cardiovasc Pharmacol.

      Volume: 55 Pages: 184-190

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cross-sectional characterization of all classes of antihypertensives in terms of central blood pressure in Japanese hypertensive patients.2010

    • Author(s)
      Miyashita H, et al
    • Journal Title

      Am J Hypertens

      Volume: 23 Pages: 260-268

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Angiotensin II type 1 receptor-activated caspase-3 through ras/mitogen-activated protein kinase/extracellular signal-regulated kinase in the rostral ventrolateral medulla is involved in sympathoexcitation in stroke-prone spontaneously hypertensive rats.2010

    • Author(s)
      Kishi T, et al
    • Journal Title

      Hypertension

      Volume: 55 Pages: 291-297

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nanoparticle-mediated endothelial cell-selective delivery of pitavastatin induces functional collateral arteries (therapeutic arteriogenesis) in a rabbit model of chronic hind limb ischemia.2010

    • Author(s)
      Oda S, et al
    • Journal Title

      J Vasc Surg.

      Volume: 52 Pages: 412-420

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Blockade of mineralocorticoid receptors improves salt-induced left-ventricular systolic dysfunction through attenuation of enhanced sympathetic drive in mice with pressure overload.2010

    • Author(s)
      Ito K, Hirooka Y, Sunagawa K
    • Journal Title

      J Hypertens.

      Volume: 28 Pages: 1449-1458

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acetylcholinesterase inhibitors attenuate atherogenesis in apolipoprotein E-knockout mice.2010

    • Author(s)
      Inanaga K, et al
    • Journal Title

      Atherosclerosis.

      Volume: 213 Pages: 52-58

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oxidative stress and central cardiovascular regulation.-Pathogenesis of hypertension and therapeutic aspects.2010

    • Author(s)
      Hirooka Y, et al
    • Journal Title

      Circ J

      Volume: 74 Pages: 827-835

    • NAID

      10026473063

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Angiotensin II type 1 receptor-activated caspase-3 throughras/mitogen-activated protein kinase/extracellular signal-regulated kinase in the rostral ventrolateral medulla is involved in sympathoexcitation in stroke-prone spontaneously hypertensive rats.2010

    • Author(s)
      Kishi T, et al
    • Journal Title

      Hypertension 55

      Pages: 291-297

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sympathoinhibition induced by centrally administered atorvastatin is associated with alteration of NAD(P)H and Mn superoxide dismutase activity in rostral ventrolateral medulla of stroke-prone spontaneously hypertensive rats.2010

    • Author(s)
      Kishi T, et al
    • Journal Title

      J Cardiovasc Pharmacol. 55

      Pages: 184-190

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Para-Hisian Pacing for a Pediatric Patient with a Congenitally Corrected Transposition of the Great Arteries(SLL).2010

    • Author(s)
      Takemoto M, et al
    • Journal Title

      Pacing Clin Electrophysiol. 33

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bionic cardiology : exploration into a wealth of controllable body parts in the cardiovascular system.2009

    • Author(s)
      Sugimachi M, Sunagawa K.
    • Journal Title

      IEEE Rev Biomed Eng. 2

      Pages: 172-186

    • Related Report
      2010 Final Research Report
  • [Journal Article] Acquisition of Brain Na Sensitivity Contributes to Salt-Induced Sympathoexcitation and Cardiac Dysfunction in Mice With Pressure Overload.2009

    • Author(s)
      Ito K, Hirooka Y, Sunagawa K.
    • Journal Title

      Circ Res. 104

      Pages: 1004-1011

    • Related Report
      2010 Final Research Report
  • [Journal Article] Servo-Controlled Hind-Limb Electrical Stimulation for Short-Term Arterial Pressure Control.2009

    • Author(s)
      Kawada T, Shimizu S, Yamamoto H, Shishido T, Kamiya A, Miyamoto T, Sunagawa K, Sugimachi M.
    • Journal Title

      Circ J. 73

      Pages: 851-859

    • Related Report
      2010 Final Research Report
  • [Journal Article] Atorvastatin improves the impaired baroreflex sensitivity via anti-oxidant effect in the rostral ventrolateral medulla of SHRSP.2009

    • Author(s)
      Kishi T, et al
    • Journal Title

      Clin Exp Hypertens. 31

      Pages: 698-704

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Olmesartan reduces oxidative stress in the brain of stroke-prone spontaneously hypertensive rats assessed by an in vivo ESR method.2009

    • Author(s)
      Araki S, et al
    • Journal Title

      Hypertens Res. 32

      Pages: 1091-1096

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of prolyl hydroxylase domain-containing protein suppressed lipopolysaccharide-induced TNF-alpha expression.2009

    • Author(s)
      Takeda K, et al
    • Journal Title

      Arterioscler Thromb Vasc Biol. 29

      Pages: 2132-2137

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Coronary aneurysm associated with coronary perforation after sirolimus-eluting stents implantation : Close follow-up exceeding 2 years by coronary 3-dimensional computed tomography.2009

    • Author(s)
      Eshima K, et al
    • Journal Title

      J Cardiol. 54

      Pages: 115-120

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bundle branch re-entry ventricular tachycardia in a patient with myotonic dystrophy.2009

    • Author(s)
      Takeda K, et al
    • Journal Title

      J Cardiol. 53

      Pages: 463-466

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Atorvastatin might improve ventricular electrostability and decelerate the deterioration of renal function in patients with heart failure and diabetes mellitus.2009

    • Author(s)
      Kishi T, et al
    • Journal Title

      J Cardiol. 53

      Pages: 341-348

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Formulation of nanoparticle-eluting stents by a cationic electrodeposition coating technology : efficient nano-drug delivery via bioabsorbable polymeric nanoparticle-eluting stents in porcine coronary arteries.2009

    • Author(s)
      Nakano K, et al
    • Journal Title

      JACC Cardiovasc Interv. 2

      Pages: 277-283

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improvement of neovascularization capacity of bone marrow mononuclear cells from diabetic mice by ex vivo pretreatment with resveratrol.2009

    • Author(s)
      Gan L, et al
    • Journal Title

      Hypertens Res. 32

      Pages: 542-547

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of inducible nitric oxide synthase in rostral ventrolateral medulla in blood pressure regulation in spontaneously hypertensive rats.2009

    • Author(s)
      Kimura Y, et al
    • Journal Title

      Clin Exp Hypertens. 31

      Pages: 281-286

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cilnidipine inhibits the sympathetic nerve activity and improves baroreflex sensitivity in patients with hypertension.2009

    • Author(s)
      Kishi T, et al
    • Journal Title

      Clin Exp Hypertens. 31

      Pages: 241-249

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Resveratrol attenuates angiotensin II-induced interleukin-6 expression and perivascular fibrosis.2009

    • Author(s)
      Inanaga K, et al
    • Journal Title

      Hypertens Res. 32

      Pages: 466-471

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic neovascularization by nanotechnology-mediated cell-selective delivery of pitavastatin into the vascular endothelium.2009

    • Author(s)
      Kubo M, et al
    • Journal Title

      Arterioscler Thromb Vasc Biol. 29

      Pages: 796-801

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nanoparticle-mediated delivery of nuclear factor kappaB decoy into lungs ameliorates monocrotaline-induced pulmonary arterial hypertension.2009

    • Author(s)
      Kimura S, et al
    • Journal Title

      Hypertension. 53

      Pages: 877-883

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acquisition of brain Na sensitivity contributes to salt-induced sympathoexcitation and cardiac dysfunction in mice with pressure overload.2009

    • Author(s)
      Ito K, et al
    • Journal Title

      Circ Res. 104

      Pages: 1004-1011

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Servo-controlled hind-limb electrical stimulation for short-term arterial pressure control.2009

    • Author(s)
      Kawada T, et al
    • Journal Title

      Circ J. 73

      Pages: 851-859

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of tumor necrosis factor-alpha-induced interleukin-6 expression by telmisartan through cross-talk of peroxisome proliferator-activated receptor-gamma with nuclear factor kappaB and CCAAT/enhancer-binding protein-beta.2009

    • Author(s)
      Tian Q, et al
    • Journal Title

      Hypertension. 53

      Pages: 798-804

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chest pain without significant coronary stenosis after implantation of sirolimus-eluting stents.2009

    • Author(s)
      Hiasa K, et al
    • Journal Title

      Intern Med. 48

      Pages: 213-217

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Soluble Flt-1 gene transfer ameliorates neointima formation after wire injury in flt-1 tyrosine kinase-deficient mice.2009

    • Author(s)
      Koga J, et al
    • Journal Title

      Arterioscler Thromb Vase Biol. 29

      Pages: 458-464

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intracardiac echocardiography-guided cardiac tumor biopsy.2009

    • Author(s)
      Higo T, et al
    • Journal Title

      Circ J 73

      Pages: 381-383

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Time-dependent changes of myocardial and systemic oxidative stress are dissociated after myocardial infarction.2009

    • Author(s)
      Inoue T, et al
    • Journal Title

      Free Radic Res. 43

      Pages: 37-46

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Computationally managed bradycardia improved cardiac energetics while restoring normal hemodynamics in heart failure.2009

    • Author(s)
      Uemura K, et al
    • Journal Title

      Ann Biomed Eng. 37

      Pages: 82-93

    • Related Report
      2009 Annual Research Report 2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Wavelet-based system identification of short-term dynamic characteristics of arterial baroreflex.2009

    • Author(s)
      Kashihara K, et al
    • Journal Title

      Ann Biomed Eng. 37

      Pages: 112-128

    • Related Report
      2009 Annual Research Report 2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acquisition of Brain Na Sensitivity Contributes to Salt-Induced Sympathoexcitation and Cardiac Dysfunction in Mice With Pressure Overload2009

    • Author(s)
      Ito K, Hirooka Y, Sunagawa K.
    • Journal Title

      Circ Res (In press)

    • Related Report
      2008 Self-evaluation Report
  • [Journal Article] Servo-Controlled Hind-Limb Electrical Stimulation for Short-Term Arterial Pressure Control2009

    • Author(s)
      Kawada T, Shimizu S, Yamamoto H, Shishido T, Kamiya A, Miyamoto T, Sunagawa K, Sugimachi M.
    • Journal Title

      Circ J. (In press)

    • Related Report
      2008 Self-evaluation Report
  • [Journal Article] Therapeutic Neovascularization by Nanotechnology-Mediated Cell-Selective Delivery of Pitavastatin Into the Vascular Endothelium.2009

    • Author(s)
      Kubo M, et al
    • Journal Title

      Arterioscler Thromb Vase Biol. (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nanoparticle-Mediated Delivery of Nuclear Factor κB Decoy Into Lungs Ameliorates Monocrotaline-Induced Pulmonary Arterial Hypertension.2009

    • Author(s)
      Kimura S, et al
    • Journal Title

      Hypertension. (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acquisition of Brain Na Sensitivity Contributes to Salt-Induced Sympathoexcitation and Cardiac Dysfunction in Mice With Pressure Overload.2009

    • Author(s)
      Ito K, et al
    • Journal Title

      Circ Res. (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Servo-Controlled Hind-Limb Electrical Stimulation for Short-Term Arterial Pressure Control.2009

    • Author(s)
      Kawada T, et al
    • Journal Title

      Circ J. (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of Tumor Necrosis Factor-α-Induced Interleukin-6 Expression by Telmisartan Through Cross-Talk of Peroxisome Proliferator-Activated Receptor-γ With Nuclear Factor κB and CCAAT/Enhancer-Binding Protein-β.2009

    • Author(s)
      Tian Q, et al
    • Journal Title

      Hypertension. (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Time-dependent changes of myocardial and systemic oxidative stress are dissociated after myocardial infarction.2009

    • Author(s)
      Inoue T, et al
    • Journal Title

      Free Radic Res. (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Soluble Flt-1 gene transfer ameliorates neointima formation after wireinjury in fit-1 tyrosine kinase-deficient mice.2009

    • Author(s)
      Koga J, et al
    • Journal Title

      Arterioscler Thromb Vase Biol. 29

      Pages: 458-464

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Muscle mechanoreflex augments arterial baroreflex-mediated dynamic sympathetic response to carotid sinus pressure.2008

    • Author(s)
      Yamamoto K, Kawada T, Kamiya A, Takaki H, Shishido T, Sunagawa K, Sugimachi M.
    • Journal Title

      Am J Physiol Heart Circ Physiol. 295

    • Related Report
      2010 Final Research Report
  • [Journal Article] Modulation of the myocardial redox state by vagal nerve stimulation after experimental myocardial infarction.2008

    • Author(s)
      Tsutsumi T, Ide T, Yamato M, Kudou W, Andou M, Hirooka Y, Utsumi H, Tsutsui H, Sunagawa K.
    • Journal Title

      Cardiovasc Res. 77

      Pages: 713-721

    • Related Report
      2010 Final Research Report
  • [Journal Article] Muscle mechanoreflex augments baroreflex-mediated dynamic sympathetic response to carotid sinus pressure2008

    • Author(s)
      Yamamoto K, Kawada T, Kamiya A, Takaki H, Shishido T, Sunagawa K, Sugimachi M.
    • Journal Title

      Am J Physiol Heart Circ Physiol 295

    • Related Report
      2008 Self-evaluation Report
  • [Journal Article] Modulation of the myocardial redox state by vagal nerve stimulation after experimental myocardial infarction2008

    • Author(s)
      Tsutsumi T, Ide T, Yamato M, Kudou W, Andou M, Hirooka Y, Utsumi H, Tsutsui H, Sunagawa K.
    • Journal Title

      Cardiovasc Res. 77

      Pages: 713-721

    • Related Report
      2008 Self-evaluation Report
  • [Journal Article] High salt intake enhances blood pressure increase during development of hypertension via oxidative stress in rostral ventrolateral medulla of spontaneously hypertensive rats.2008

    • Author(s)
      Koga Y, et al
    • Journal Title

      Hypertens Res. 31

      Pages: 2075-2083

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Azelnidipine decreases sympathetic nerve activity via antioxidant effect in the rostral ventrolateral medulla of stroke-prone spontaneously hypertensive rats.2008

    • Author(s)
      Konno S, et al
    • Journal Title

      J Cardiovasc Pharmacol. 52

      Pages: 555-560

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Essential role of angiotensin II type la receptors in the host vascular wall, but not the bone marrow, in the pathogenesis of angiotensin II-induced atherosclerosis.2008

    • Author(s)
      Koga J, et al
    • Journal Title

      Hypertens Res. 31

      Pages: 1791-1800

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mitochondria-derived reactive oxygen species mediate sympathoexcitation induced by angiotensin II in the rostral ventrolateral medulla.2008

    • Author(s)
      Nozoe M, et al
    • Journal Title

      J Hypertens. 26

      Pages: 2176-2184

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Local delivery of imatinib mesylate (STI571)-incorporated nanoparticle exvivo suppresses vein graft neointima formation.2008

    • Author(s)
      Kimura S, et al
    • Journal Title

      Circulation. 118

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of Rho-kinase in the brainstem enhances sympathetic drive in mice with heart failure.2008

    • Author(s)
      Ito K, et al
    • Journal Title

      Auton Neurosci. 142

      Pages: 77-81

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Contrasting effects of presynaptic alpha2-adrenergic autoinhibition and pharmacologic augmentation of presynaptic inhibition on sympathetic heart rate control.2008

    • Author(s)
      Miyamoto T, et al
    • Journal Title

      Am J Physiol Heart Circ Physiol. 295

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reverse of age-dependent memory impairment and mitochondrial DNA damage in microglia by an overexpression of human mitochondrial transcription factor a in mice.2008

    • Author(s)
      Hayashi Y, et al
    • Journal Title

      J Neurosci. 28

      Pages: 8624-8634

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Muscle mechanoreflex augments arterial baroreflex-mediated dynamicsympathetic response to carotid sinus pressure.2008

    • Author(s)
      Yamamoto K, et al
    • Journal Title

      Am J Physiol Heart Circ Physiol. 295

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Liver X receptor activator downregulates angiotensin II type 1 receptor expression through dephosphorylation of Spl.2008

    • Author(s)
      Imayama l, et al
    • Journal Title

      Hypertension. 51

      Pages: 1631-1636

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Effects of valsartan or amlodipine on endothelial function and oxidative stress after one year follow-up in patients with essential hypertension.2008

    • Author(s)
      Hirooka Y, et al
    • Journal Title

      Clin Exp Hypertens. 30

      Pages: 267-276

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] SIRT1, a longevity gene, downregulates angiotensin II type 1 receptorexpression in vascular smooth muscle cells.2008

    • Author(s)
      Miyazaki R, et al.
    • Journal Title

      Arterioscler Thromb Vasc Biol. 28

      Pages: 1263-1269

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of anaesthesia-induced alterations in haemodynamics on in vivo kinetics of nitroxyl probes in electron spin resonance spectroscopy.2008

    • Author(s)
      Tsutsumi T, et al
    • Journal Title

      Free Radic Res. 42

      Pages: 305-311

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Atorvastatin reduces oxidative stress in the rostral ventrolateral medulla of stroke-prone spontaneously hypertensive rats.2008

    • Author(s)
      Kishi T, et al
    • Journal Title

      Clin Exp Hypertens. 30

      Pages: 3-11

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of Mstl in tumor necrosis factor-alpha-induced apoptosis of endothelial cells.2008

    • Author(s)
      Ohtsubo H, et al
    • Journal Title

      Biochem Biophys Res Commun. 367

      Pages: 474-480

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modulation of the myocardial redox state by vagal nerve stimulation after experimental myocardial infarction.2008

    • Author(s)
      Tsutsumi T, et al
    • Journal Title

      Cardiovasc Res. 77

      Pages: 713-721

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Azelnidipine has anti-atherosclerotic effects independent of its blood pressure-lowering actions in monkeys and mice.2008

    • Author(s)
      Nakano K, et al
    • Journal Title

      Atherosclerosis. 196

      Pages: 172-179

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of anaesthesia-induced alterations in haemodynamics on in vivo kinetics of nitroxyl probes in electron spin resonance spectroscopy2008

    • Author(s)
      Tsutsumi T, et. al.
    • Journal Title

      Free Radic Res 42

      Pages: 305-311

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Matrix metalloproteinase-2 mediates stretch-induced activation of skeletal muscle satellite cells in a nitric oxide-dependent manner.2008

    • Author(s)
      Yamada M, et. al.
    • Journal Title

      Int J Biochem Cell Biol. (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Atorvastatin reduces oxidative stress in the rostral ventrolateral medulla of stroke-prone spontaneously hypertensive rats.2008

    • Author(s)
      Kishi T, et. al.
    • Journal Title

      Clin Exp Hypertens 30

      Pages: 3-11

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of Mstl in tumor necrosis factor-alpha-induced apoptosis of endothelial cells2008

    • Author(s)
      Ohtsubo H, et. al.
    • Journal Title

      Biochem Biophys Res Commun 367

      Pages: 474-480

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modulation of the myocardial redox state by vagal nerve stimulation after experimental myocardial infarction2008

    • Author(s)
      Tsutsumi T, et. al.
    • Journal Title

      Cardiovasc Res. 77

      Pages: 713-721

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of ouabain-induced noradrenaline and acetylcholine release from in situ cardiac autonomic nerve endings2007

    • Author(s)
      Yamazaki T, et. al.
    • Journal Title

      Acta Physiol(Oxf). 191

      Pages: 275-284

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efferent vagal nerve stimulation induces tissue inhibitor of metalloproteinase-1 in myocardial ischemia-reperfusion injury in rabbit.2007

    • Author(s)
      Uemura K, et. al.
    • Journal Title

      Am J Physiol Heart Circ Physiol. 293

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Angiotensin II type I receptor blocker attenuates myocardial remodeling and preserves diastolic function in diabetic heart.2007

    • Author(s)
      Tsutsui H, et. al.
    • Journal Title

      Hypertens Res. 30

      Pages: 439-449

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of Racl-derived reactive oxygen species in nucleus tractus solitarius decreases blood pressure and heart rate in stroke-prone spontaneously hypertensive rats.2007

    • Author(s)
      Nozoe M, et. al.
    • Journal Title

      Hypertension. 50

      Pages: 62-68

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inducible cAMP early repressor inhibits growth of vascular smooth muscle cell2007

    • Author(s)
      Ohtsubo, H, et. al.
    • Journal Title

      Arterioscler Thromb Vasc Biol. 27

      Pages: 1549-1955

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tumor necrosis factor-alpha is toxic via receptor 1 and protective via receptor 2 in a murine model of myocardial infarction.2007

    • Author(s)
      Monden Y, et. al.
    • Journal Title

      Am J Physiol Heart Circ Physiol. 293

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Soluble TNF receptors prevent apoptosis in infiltrating cells and promote ventricular ruprure and remodeling after myocardial infarction2007

    • Author(s)
      Monden Y, et. al.
    • Journal Title

      Cardiovasc Res. 73

      Pages: 794-805

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pressor response induced by central angiotensin II is mediated by activation of Rho/Rho-kinase pathway via ATl receptors.2007

    • Author(s)
      Sagara Y, et. al.
    • Journal Title

      J Hypertens. 25

      Pages: 399-406

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-acting calcium channel blocker, azelnidipine, increases endothelial nitric oxide synthase in the brain and inhibits sympathetic nerve activity.2007

    • Author(s)
      Kimura Y, et. al.
    • Journal Title

      Clin Exp Hypertens. 29

      Pages: 13-21

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Short-term electroacupuncture at Zusanli resets the arterial baroreflex neural arc toward lower sympathetic nerve activity.2006

    • Author(s)
      Michikami D, Kamiya A, Kawada T, Inagaki M, Shishido T, Yamamoto K, Ariumi H, Iwase S, Sugenoya J, Sunagawa K, Sugimachi M.
    • Journal Title

      Am J Physiol Heart Circ Physiol. 291

    • Related Report
      2010 Final Research Report 2006 Annual Research Report
  • [Journal Article] Short-term electroacupuncture at Zusanli resets the arterial baroreflex neural arc toward lower sympathetic nerve activity2006

    • Author(s)
      Michikami D, Kamiya A, Kawada T, Inagaki M, Shishido T, Yamamoto K, Ariumi H, Iwase S, Sugenoya J, Sunagawa K, Sugimachi M.
    • Journal Title

      Am J Physiol Heart Circ Physiol 291

    • Related Report
      2008 Self-evaluation Report
  • [Journal Article] Stent-based local delivery of nuclear factor-kappaB decoy attenuates in-stent restenosis in hypercholesterolemic rabbits.2006

    • Author(s)
      Ohtani K, Egashira K, Nakano K, Zhao G, Funakoshi K, Ihara Y, Kimura S, Tominaga R, Morishita R, Sunagawa K.
    • Journal Title

      Circulation 114

      Pages: 2773-2779

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Angiotensin II type 1 receptor blockade attenuates in-stent restenosis by inhibiting inflammation and progenitor cells.2006

    • Author(s)
      Ohtani K, Egashira K, Ihara Y, Nakano K, FUnakoshi K, Zhao G, Sata M, Sunagawa K.
    • Journal Title

      Hypertension 48

      Pages: 664-670

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Telmisartan downregulates angiotensin II type 1 receptor through activation of peroxisome proliferator-activated receptor gamma.2006

    • Author(s)
      Imayama I, Ichiki T, Inanaga K, Ohtsubo H, Fukuyama K, Ono H, Hashiguchi Y, Sunagawa K.
    • Journal Title

      Cardiovasc Res. 72

      Pages: 184-190

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Reversible vagal blockade in conscious rats using a targeted delivery device.2006

    • Author(s)
      Zheng C, Kawada T, Li M, Sato T, Sunagawa K, Sugimachi M.
    • Journal Title

      J Neurosci Methods. 156

      Pages: 71-75

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Automated drug delivery system to control systemic arterial pressure, cardiac output, and left heart filling pressure in acute decompensated heart failure.2006

    • Author(s)
      Uemura K, Kamiya A, Hidaka I, Kawada T, Shimizu S, Shishido T, Yoshizawa M, Sugimachi M, Sunagawa K.
    • Journal Title

      J Appl Physiol. 100

      Pages: 1278-1286

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Peak Systolic Mitral Annulus Velocity Reflects the Status of Ventricular-Arterial Coupling-Theoretical and Experimental Analyses.

    • Author(s)
      Uemura K, et al
    • Journal Title

      J Am Soc Echocardiogr

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] NPC1L1 Inhibition with Ezetimibe Suppresses Enhanced Formation of Aortic Atherosclerosis Induced by Dietary Cholesterol Oxidation Products in ApoE-deficient Mice2010

    • Author(s)
      Sato K, et al
    • Organizer
      Scientific Sessions 2010, American Heart Association
    • Place of Presentation
      Chicago, U.S.A.
    • Year and Date
      2010-11-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Nanoparticle-mediated Endothelial Cell-selective Delivery of Pioglitazone Enhances Therapeutic Efficacy of Therapeutic Angiogenesis and Arteriogenesis after Hindlimb Ischemia in Mice2010

    • Author(s)
      Nagahama R, et al
    • Organizer
      Scientific Sessions 2010, American Heart Association
    • Place of Presentation
      Chicago, U.S.A.
    • Year and Date
      2010-11-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Nanoparticle-Mediated Monocyte-Selective Delivery of Pitavastatin Prevents Angiotensin II-Induced Abdominal Aortic Aneurysm Formation in ApoE-Deficient Mice2010

    • Author(s)
      Katsuki S, et al
    • Organizer
      Scientific Sessions 2010, American Heart Association
    • Place of Presentation
      Chicago, U.S.A.
    • Year and Date
      2010-11-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] AT_1 Receptor-Activated Toll-Like Receptor 4 in the Brainstem Causes Sympathoexcitation in Mice With Heart Failure2010

    • Author(s)
      Ogawa K, et al
    • Organizer
      Scientific Sessions 2010, American Heart Association
    • Place of Presentation
      Chicago, U.S.A.
    • Year and Date
      2010-11-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Endogenous Angiotensin-(1-7) Activity in the Rostral Ventrolateral Medulla Is Enhanced in Spontaneously Hypertensive Rats via Sympathetic Nerve Activity2010

    • Author(s)
      Nakagaki T, et al
    • Organizer
      Scientific Sessions 2010, American Heart Association
    • Place of Presentation
      Chicago, U.S.A.
    • Year and Date
      2010-11-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Nanoparticle-Mediated Monocyte-Selective Delivery of Pitavastatin Inhibits Monocyte Activation and Attenuates Plaque Destabilization and Rupture in ApoE-Deficient Mice2010

    • Author(s)
      Katsuki S, et al
    • Organizer
      Scientific Sessions 2010, American Heart Association
    • Place of Presentation
      Chicago, U.S.A.
    • Year and Date
      2010-11-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] Dentification of Rho-associated Kinase 2 (ROCK2) as a Key Molecule Generating the Intrinsic Circadian Rhythm of Vascular Contractility2010

    • Author(s)
      Saito T, et al
    • Organizer
      Scientific Sessions 2010, American Heart Association
    • Place of Presentation
      Chicago, U.S.A.
    • Year and Date
      2010-11-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] Neuregulin-1/ErbB Pathway Modulation of Major Neurotransmitters in the Cardiovascular Center is Crucial for Neural Regulation of Blood Pressure -Possible Involvement of Neuregulin-1/ErbB Pathway in Neural Mechanisms of Hypertension-2010

    • Author(s)
      Matsukawa R, et al
    • Organizer
      Scientific Sessions 2010, American Heart Association
    • Place of Presentation
      Chicago, U.S.A.
    • Year and Date
      2010-11-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] Reactive Oxygen Species in Rostral Ventrolateral Medulla Contribute to Neural Mechanisms of Hypertension by Modulating Paraventricular Nucleus of Hypothalamus2010

    • Author(s)
      Nishihara M, et al
    • Organizer
      Scientific Sessions 2010, American Heart Association
    • Place of Presentation
      Chicago, U.S.A.
    • Year and Date
      2010-11-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] NPC1L1 Inhibition with Ezetimibe Prevents Accelerated Plaque Destabilization and Rupture Induced by Dietary Cholesterol Oxidation Products in ApoE-deficient Mice2010

    • Author(s)
      Sato K, et al
    • Organizer
      Scientific Sessions 2010, American Heart Association
    • Place of Presentation
      Chicago, U.S.A.
    • Year and Date
      2010-11-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] Baroreflex failure makes patients super susceptible to volume overload and predisposes patients to pulmonary edema in the absence of left ventricular systolic failure.2010

    • Author(s)
      Sunagawa K.
    • Organizer
      21th International Symposium on the autonomic nervous system.
    • Place of Presentation
      Orland, U.S.A.
    • Year and Date
      2010-11-05
    • Related Report
      2010 Final Research Report
  • [Presentation] Baroreflex regulates arterial pressure by modulating vascular properties, not by modulating ventricular properties.2010

    • Author(s)
      Sunagawa K.
    • Organizer
      21th International Symposium on the autonomic nervous system.
    • Place of Presentation
      Orland, U.S.A.
    • Year and Date
      2010-11-05
    • Related Report
      2010 Final Research Report
  • [Presentation] Baroreflex failure makes patients super susceptible to volume overload and predisposes patients to pulmonary edema in the absence of left ventricular systolic failure.2010

    • Author(s)
      Sunagawa K.
    • Organizer
      21^<th> International Symposium on the autonomic nervous system
    • Place of Presentation
      Florida, U.S.A.
    • Year and Date
      2010-11-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] Baroreflex regulates arterial pressure by modulating vascular properties, not by modulating ventricular properties.2010

    • Author(s)
      Sunagawa K.
    • Organizer
      21^<th> International Symposium on the autonomic nervous system
    • Place of Presentation
      Florida, U.S.A.
    • Year and Date
      2010-11-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] Estimated Venous Return Surface and Cardiac Output Curve Precisely Predicts New Hemodynamics after Volume Change.2010

    • Author(s)
      Sugimachi M, Sunagawa K, Uemura K, Kamiya A, Shimizu S, Inagaki M, Shishido T.
    • Organizer
      IEEE Engineering in Medicine and Biology Society.
    • Place of Presentation
      Buenos Aires, Argentina
    • Year and Date
      2010-09-03
    • Related Report
      2010 Final Research Report
  • [Presentation] Automated Drug Delivery System for the Management of Hemodynamics and Cardiac Energetic in Acute Heart Failure.2010

    • Author(s)
      Uemura K, Sugimachi M, Kawada T, Sunagawa K.
    • Organizer
      IEEE Engineering in Medicine and Biology Society.
    • Place of Presentation
      Buenos Aires, Argentina
    • Year and Date
      2010-09-03
    • Related Report
      2010 Final Research Report
  • [Presentation] Estimated Venous Return Surface and Cardiac Output Curve Precisely Predicts New Hemodynamics after Volume Change.2010

    • Author(s)
      Sugimachi M, et al
    • Organizer
      32^<nd> Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    • Place of Presentation
      Buenos Aires, Argentina
    • Year and Date
      2010-09-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] Automated Drug Delivery System for the Management of Hemodynamics and Cardiac Energetic in Acute Heart Failure.2010

    • Author(s)
      Uemura K, et al
    • Organizer
      32^<nd> Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    • Place of Presentation
      Buenos Aires, Argentina
    • Year and Date
      2010-09-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] Development of Artificial Bionic Baroreflex System.2010

    • Author(s)
      Sunagawa K, Sugimachi M.
    • Organizer
      32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society.
    • Place of Presentation
      Buenos Aires, Argentina
    • Year and Date
      2010-09-02
    • Related Report
      2010 Final Research Report
  • [Presentation] How to quantitatively synthesize dynamic changes in arterial pressure from baroreflexly modulated ventricular and arterial properties.2010

    • Author(s)
      Sakamoto T, Murayama Y, Tobushi T, Sakamoto K, Tanaka A, Tsutsumi T, Sunagawa K.
    • Organizer
      IEEE Engineering in Medicine and Biology Society.
    • Place of Presentation
      Buenos Aires, Argentina
    • Year and Date
      2010-09-02
    • Related Report
      2010 Final Research Report
  • [Presentation] Physiological Significance of Pressure-Volume Relationship : A Load-Independent Index and a Determinant of Pump Function.2010

    • Author(s)
      Sugimachi M, Sunagawa K, Uemura K, Shishido T.
    • Organizer
      IEEE Engineering in Medicine and Biology Society.
    • Place of Presentation
      Buenos Aires, Argentina
    • Year and Date
      2010-09-02
    • Related Report
      2010 Final Research Report
  • [Presentation] The Pressure-Volume Relationship of the Heart : Past, Present and Future.2010

    • Author(s)
      Sunagawa K.
    • Organizer
      IEEE Engineering in Medicine and Biology Society.
    • Place of Presentation
      Buenos Aires, Argentina
    • Year and Date
      2010-09-02
    • Related Report
      2010 Final Research Report
  • [Presentation] Development of Artificial Bionic Baroreflex System2010

    • Author(s)
      Sunagawa K.
    • Organizer
      32^<nd> Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    • Place of Presentation
      Buenos Aires, Argentina
    • Year and Date
      2010-09-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] How to Quantitatively Synthesize Dynamic Changes in Arterial Pressure from Baroreflexly Modulated Ventricular and Arterial Properties.2010

    • Author(s)
      Sakamoto T, et al
    • Organizer
      32^<nd> Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    • Place of Presentation
      Buenos Aires, Argentina
    • Year and Date
      2010-09-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] Physiological Significance of Pressure-Volume Relationship : A Load-Independent Index and a Determinant of Pump Function.2010

    • Author(s)
      Sugimachi M, et al
    • Organizer
      32^<nd> Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    • Place of Presentation
      Buenos Aires, Argentina
    • Year and Date
      2010-09-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] The Pressure-Volume Relationship of the Heart : Past, Present and Future.2010

    • Author(s)
      Sunagawa K.
    • Organizer
      32^<nd> Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    • Place of Presentation
      Buenos Aires, Argentina
    • Year and Date
      2010-09-02
    • Related Report
      2010 Annual Research Report
  • [Presentation]2010

    • Author(s)
      Hosokawa K, Kawada T, Ando M, Tanaka A, Sakamoto T, Onitsuka K, Murayama Y, Ide T, Sunagawa K.
    • Organizer
      Experimental Biology 2010.
    • Place of Presentation
      Anaheim, U.S.A.
    • Year and Date
      2010-04-28
    • Related Report
      2010 Final Research Report
  • [Presentation] Equilibrium analysis between the venous return surface and cardiac output curve enables us to predict hemodynamic impact of percutaneous cardiopulmonary support.2010

    • Author(s)
      Tanaka A, Sunagawa K.
    • Organizer
      Experimental Biology 2010.
    • Place of Presentation
      Anaheim, U.S.A.
    • Year and Date
      2010-04-28
    • Related Report
      2010 Final Research Report
  • [Presentation] Electrical vagal afferent stimulation inhibits sympathetic nervous activity irrespective of baroreflex activation without lowering blood pressure.2010

    • Author(s)
      Hosokawa K, et al
    • Organizer
      Experimental Biology 2010
    • Place of Presentation
      Anaheim, U.S.A.
    • Year and Date
      2010-04-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] Equilibrium analysis between the venous return surface and cardiac output curve enables us to predict hemodynamic impact of percutaneous cardiopulmonary support.2010

    • Author(s)
      Tanaka A, Sunagawa K
    • Organizer
      Experimental Biology 2010
    • Place of Presentation
      Anaheim, U.S.A.
    • Year and Date
      2010-04-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] Telmisartan improves cognitive function through the increase in neurotrophic factor and inhibition of apoptosis in hippocampus of rats with metabolic syndrome.2010

    • Author(s)
      Kishi T, Hirooka Y, Sunagawa K.
    • Organizer
      Experimental Biology 2010
    • Place of Presentation
      Anaheim, U.S.A.
    • Year and Date
      2010-04-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] Intrinsic circadian oscillation of myosin light chain phosphorylation in vascular smooth muscle cells.2010

    • Author(s)
      Saito T, et al
    • Organizer
      Experimental Biology 2010
    • Place of Presentation
      Anaheim, U.S.A.
    • Year and Date
      2010-04-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] Reduced reactive oxgen species generation in rostral ventrolateral medulla suppresses the pressor response induced by the excitation of the paraventricular nucleus of the hypothalamus in spontaneously hypertensiverats.2010

    • Author(s)
      Nishihara M, et al
    • Organizer
      Experimental Biology 2010
    • Place of Presentation
      Anaheim, U.S.A.
    • Year and Date
      2010-04-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] Telmisartan inhibits sympathetic nerve activity through the inhibition of oxidative stress and increase in NO and GABA in the brain of hypertensive rats.2010

    • Author(s)
      Kishi T, Hirooka Y, Sunagawa K.
    • Organizer
      Experimental Biology 2010.
    • Place of Presentation
      Anaheim, U.S.A.
    • Year and Date
      2010-04-26
    • Related Report
      2010 Final Research Report
  • [Presentation] Angiotensin (1-7) into rostral ventrolateral medulla is enhanced in spontaneously hypertensive rats2010

    • Author(s)
      Nakagaki T, Hirooka Y, Ito K, Hoka S, Sunagawa K.
    • Organizer
      Experimental Biology 2010.
    • Place of Presentation
      Anaheim, U.S.A.
    • Year and Date
      2010-04-26
    • Related Report
      2010 Final Research Report
  • [Presentation] Quantitative synthesis of dynamic baroreflex pressure regulation using baroreflex induced changes in ventricular and vascular properties.2010

    • Author(s)
      Sakamoto T, Tsutsumi T, Murayama Y, Tanaka A, Tobushi T, Sakamoto K, Sunagawa K.
    • Organizer
      Experimental Biology 2010.
    • Place of Presentation
      Anaheim, U.S.A.
    • Year and Date
      2010-04-26
    • Related Report
      2010 Final Research Report
  • [Presentation] Quantitative synthesis of dynamic baroreflex pressure regulation using baroreflex induced changes in ventricular and vascular properties.2010

    • Author(s)
      Sakamoto T, et al
    • Organizer
      Experimental Biology 2010
    • Place of Presentation
      Anaheim, U.S.A.
    • Year and Date
      2010-04-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] Telmisartan inhibits sympathetic nerve activity through the reduction of oxidative stress and release of GABA in RVLM of hypertensive rats.2010

    • Author(s)
      Kishi T, Hirooka Y, Sunagawa K.
    • Organizer
      Experimental Biology 2010
    • Place of Presentation
      Anaheim, U.S.A.
    • Year and Date
      2010-04-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] Angiotensin (1-7) into rostral ventrolateral medulla is enhances in spontaneously hypertensive rats.2010

    • Author(s)
      Nakagaki T, et al
    • Organizer
      Experimental Biology 2010
    • Place of Presentation
      Anaheim, U.S.A.
    • Year and Date
      2010-04-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] Neuregulin-1/erbB signaling in rostral ventrolateral medulla of brainstem is involves in blood pressure regulation alteration of major neurotransmitters.2010

    • Author(s)
      Matsukawa R, et al
    • Organizer
      Experimental Biology 2010
    • Place of Presentation
      Anaheim, U.S.A.
    • Year and Date
      2010-04-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] Apoptosis of astrocyte mediated by Toll-like receptor 4 and apoptosis signal-regulating 1 in cardiovascular center causes excessive sympathoexcitation in hypertensive rats.2010

    • Author(s)
      Kishi T, et al
    • Organizer
      Experimental Biology 2010
    • Place of Presentation
      Anaheim, U.S.A.
    • Year and Date
      2010-04-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] Toll-like receptor expression is increased via activation of AT1 receptor in the brain associated with sympathoexcitation in mice with heart failure.2010

    • Author(s)
      Ogawa K, et al
    • Organizer
      Experimental Biology 2010
    • Place of Presentation
      Anaheim, U.S.A.
    • Year and Date
      2010-04-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] Vagal Nerve Stimulation during Ischemia-Reperfusion(I/R)Reduces the Infarct Size and Ameliorates Subsequent Left Ventricular(LV)Dysfunction/Remodeling2010

    • Author(s)
      Ando M, et al
    • Organizer
      第74回日本循環器学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2010-03-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] Arterial Pressure Destabilization in Patients with Cervical Spinal Cord Injury Requires Tailored Therapeutic Strategies Depending upon the Post Injury Period2010

    • Author(s)
      Sakamoto T, et al
    • Organizer
      第74回日本循環器学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2010-03-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] Decreases in Brain Sigma-1 Receptor Contribute to Sympathetic Hyperactivation in Mice with Heart Failure.2010

    • Author(s)
      Ito K, et al
    • Organizer
      第74回日本循環器学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2010-03-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] Telmisartan Improves Endothelial Function and Decreases Sympathetic Nerve Activity to a Greater Extent than Candesartan in Patients with Metabolic Syndrome2010

    • Author(s)
      Kishi T, et al
    • Organizer
      第74回日本循環器学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2010-03-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] Apoptosis of Astrocyte Mediated by Toll-like Receptor 4 and Apoptosis Signal-Regulating 1 in Cardiovascular Center Causes Sympathoexcitation in Hypertensive Rats2010

    • Author(s)
      Kishi T, et al
    • Organizer
      第74回日本循環器学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2010-03-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] Electrical Afferent Vagal Stimulation Markedly Inhibits Sympathetic Nervous Activity Irrespective of Baroreflex Activation without Lowering Blood Pressure.2010

    • Author(s)
      Hosokawa K, et al.
    • Organizer
      第74回日本循環器学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2010-03-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] Sildenafil Improves Exercise Tolerance in Patients with Refractory Heart Failure through Ameliorating Right Ventricular Afterload Mismatch2010

    • Author(s)
      Sakamoto T, et al
    • Organizer
      第74回日本循環器学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2010-03-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] AT1 Receptor-activated Ras-induced Apoptosis and P53-induced Senescence in the Cardiovascular Center of Brainstem Contributes to Sympathoexcitaion of Hypertensive Rats.2010

    • Author(s)
      Kishi T, et al
    • Organizer
      第74回日本循環器学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2010-03-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] Neuregulin-1/erbB Signaling in the Rostral Ventrolateral Medulla(RVLM)of Brainstem Contributes to Neural Regulation of Blood Pressure.2010

    • Author(s)
      Matsukawa R, et al
    • Organizer
      第74回日本循環器学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2010-03-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] Reduction of ErbB receptors in the Brainstem Contributes to Neural Mechanisms of Hypertension.2010

    • Author(s)
      Matsukawa R, et al
    • Organizer
      第74回日本循環器学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2010-03-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] Telmisartan Inhibits Sympathetic Nerve Activity through the Reduction of Oxidative Stress and Release of GABA in RVLM of Hypertensive Rats.2010

    • Author(s)
      Kishi T, et al
    • Organizer
      第74回日本循環器学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2010-03-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] The Reduction of Brain Sigma-1 Receptor Contributes to Sympathetic Hyperactivation in Heart Failure.2009

    • Author(s)
      Ito K, Hirooka Y, Sunagawa K.
    • Organizer
      Scientific Sessions 2009 of the American Heart Association.
    • Place of Presentation
      Orland, U.S.A.
    • Year and Date
      2009-11-18
    • Related Report
      2010 Final Research Report
  • [Presentation] Left Ventricular Hypertrophy Enhances the Expression of Mineralocorticoid Receptor and Epithelial Na Channels in the Brain and Leads to Salt-sensitive Sympathetic Hyperactivation and Left Ventricular Dysfunction.2009

    • Author(s)
      Ito K, Hirooka Y, Sunagawa K.
    • Organizer
      Scientific Sessions 2009 of the American Heart Association.
    • Place of Presentation
      Orland, U.S.A.
    • Year and Date
      2009-11-18
    • Related Report
      2010 Final Research Report
  • [Presentation] The Reduction of Brain Sigma-1 Receptor Contributes to Sympathetic Hyperactivation in Heart Failure2009

    • Author(s)
      Ito K, et al
    • Organizer
      Scientific Sessions of the American Heart Association
    • Place of Presentation
      Orland
    • Year and Date
      2009-11-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] Impact of Bionic Cardiology in Treating Refractory Cardiovascular Diseases.2009

    • Author(s)
      Sunagawa K.
    • Organizer
      The 5^<th> China-Japan Cardiovascular Forum.
    • Place of Presentation
      Beijind, Chaina
    • Year and Date
      2009-11-12
    • Related Report
      2010 Final Research Report
  • [Presentation] Dysregulation of brain MR-ENaCs pathway contributes to the acquisition of brain Na sensitivity in mice with LVH2009

    • Author(s)
      伊藤浩司, 他
    • Organizer
      第13回日本心不全学会
    • Place of Presentation
      福岡市
    • Year and Date
      2009-10-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] エプレレノンは圧負荷モデルにおける脳内Na感受性亢進を抑制することによって食塩負荷に伴う交感神経活性化を軽減し心機能を改善する。-脳内MR-ENaC経路の重要性2009

    • Author(s)
      伊藤浩司, 他
    • Organizer
      第32回日本高血圧学会総会
    • Place of Presentation
      大津市
    • Year and Date
      2009-10-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] Bionic autonomic neuromodulation revolutionizes cardiology in the 21st century.2009

    • Author(s)
      Sunagawa K.
    • Organizer
      31^<st> Annual International Conference of the IEEE Engineering in Medicine and Biokigy Society.
    • Place of Presentation
      Mineapolis, U.S.A.
    • Year and Date
      2009-09-03
    • Related Report
      2010 Final Research Report
  • [Presentation] Bionic autonomic neuromodulation revolutionizes cardiology in the 21st century.2009

    • Author(s)
      Sunagawa K
    • Organizer
      EMBC 2009
    • Place of Presentation
      Minneapolis
    • Year and Date
      2009-09-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] Transneural Treatment in Patients with Arterial Pressure Dysregulation.2009

    • Author(s)
      Sunagawa K.
    • Organizer
      17^<th> Asian Pacific Congress of Cardiology.
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2009-05-21
    • Related Report
      2010 Final Research Report
  • [Presentation] Equilibrium analysis between the venous return surface and cardiac output curve enables us to predict hemodynamic impact of percutaneous cardiopulmonary support.2009

    • Author(s)
      Tanaka A, Tsutsumi T, Sakamoto K, Hosokawa K, Murayama Y, Sunagawa K.
    • Organizer
      Experimental Biology 2009.
    • Place of Presentation
      New Orleans, U.S.A.
    • Year and Date
      2009-04-20
    • Related Report
      2010 Final Research Report
  • [Presentation] Brain salt sensitivity in mice with LVH is enhanced via Rho-kinase pathway through ENaC activation.2009

    • Author(s)
      Ito K, Hirooka Y, Sunagawa K.
    • Organizer
      Experimental Biology 2009.
    • Place of Presentation
      New Orleans, U.S.A.
    • Year and Date
      2009-04-19
    • Related Report
      2010 Final Research Report
  • [Presentation] Brain salt sensitivity in mice with LVH is enhanced via Rho-kinase pathway through ENaC activation2009

    • Author(s)
      Ito K, et al
    • Organizer
      Experimental Biology 2009
    • Place of Presentation
      New Orleans
    • Year and Date
      2009-04-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] Cholinergic stimulation by donepezil as a novel antiatherotic treatment2009

    • Author(s)
      Inanaga K, et al
    • Organizer
      第73回日本循環器学会学術集会総会
    • Place of Presentation
      大阪
    • Year and Date
      2009-03-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] Mitochondrial DNA, a Novel Therapeutic Target for Heart Failure2009

    • Author(s)
      Ide T, et al
    • Organizer
      第73回日本循環器学会学術集会総会
    • Place of Presentation
      大阪
    • Year and Date
      2009-03-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] A novel anti-inflammatory effect of resveratrol through suppression of AngiotensinII-induced Hypertension and Interleukin-6 production2009

    • Author(s)
      Inanaga K, et al
    • Organizer
      第73回日本循環器学会学術集会総会
    • Place of Presentation
      大阪
    • Year and Date
      2009-03-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] SIRT1, a Longevity Gene, Downregulates Angiotensin II Type 1 Receptor Expression.2009

    • Author(s)
      Miyazaki R, et al
    • Organizer
      第73回日本循環器学会学術集会総会
    • Place of Presentation
      大阪
    • Year and Date
      2009-03-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] Chronic Kidney Disease (CKD)Deteriorates Left Ventricular(LV) Diastolic Function, Promotes Remodeling and Synergistically Worsens Survival after Myocardial Infarction(MI).2009

    • Author(s)
      Inoue T, et al
    • Organizer
      第73回日本循環器学会学術集会総会
    • Place of Presentation
      大阪
    • Year and Date
      2009-03-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] Cholinergic Stimulation by Donepezil is a Novel Antiangiogenic approach.2009

    • Author(s)
      Miyazaki R, et al
    • Organizer
      第73回日本循環器学会学術集会総会
    • Place of Presentation
      大阪
    • Year and Date
      2009-03-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] Short-term Vagal Nerve Stimulation protects myocardium from ischemia-reperfusion (I/R)injury2009

    • Author(s)
      Ando M, et al
    • Organizer
      第73回日本循環器学会学術集会総会
    • Place of Presentation
      大阪
    • Year and Date
      2009-03-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] Prolyl hydroxylase inhibitors attenuated acute inflammatory responses hypoxia-inducible factor independent manner2009

    • Author(s)
      Takeda K, et al
    • Organizer
      第73回日本循環器学会学術集会総会
    • Place of Presentation
      大阪
    • Year and Date
      2009-03-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] Ras/p38 MAPK/ERK-activated Caspase 3-dependent Apoptotic Pathway in Rostral Ventrolateral Medulla Increases Sympathetic Nerve Activity in Hypertensive Rats2009

    • Author(s)
      Kishi T, et al
    • Organizer
      第73回日本循環器学会学術集会総会
    • Place of Presentation
      大阪
    • Year and Date
      2009-03-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] Intracerebroventricular-Infusion of Atorvastatin Reduces Sympathetic Nerve Activity by Inhibition of Rac1/NAD (P)H Oxidase and Upregulation ofMn-SOD in SHRSP2009

    • Author(s)
      Kishi T, et al
    • Organizer
      第73回日本循環器学会学術集会総会
    • Place of Presentation
      大阪
    • Year and Date
      2009-03-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] MAPK/ERK Pathway Plays a Major Role in Redox Sensitive Signal Transduction in the RVLM of SHRSP.2009

    • Author(s)
      Koga Y, et al
    • Organizer
      第73回日本循環器学会学術集会総会
    • Place of Presentation
      大阪
    • Year and Date
      2009-03-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] Atorvastatin Attenuates Telomere-dependent and Independent Neural Cell Senescence in the Cardiovascular Center of Brainstem in Stroke-prone Spontaneously Hypertensive Rats2009

    • Author(s)
      Kishi T, et al
    • Organizer
      第73回日本循環器学会学術集会総会
    • Place of Presentation
      大阪
    • Year and Date
      2009-03-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] Enhanced brain Na sensitivity contributes to salt-inducedsympathetichyperactivation and deterioration of cardiac function in mice with LVH2009

    • Author(s)
      Ito K, et al
    • Organizer
      第73回日本循環器学会学術集会総会
    • Place of Presentation
      大阪
    • Year and Date
      2009-03-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] Aldosterone and Salt Induces Hypertension Associated with Increased Oxidative Stress in the Brain of Apolipoprotein E Knockout Mice2009

    • Author(s)
      Araki S, et al
    • Organizer
      第73回日本循環器学会学術集会総会
    • Place of Presentation
      大阪
    • Year and Date
      2009-03-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] Increased Oxidative Stress in Cardiovascular Center of Brain Stem Causes Sympatho-excitation in Dietary-induced Obesity Rat2009

    • Author(s)
      Konno S, et al
    • Organizer
      第73回日本循環器学会学術集会総会
    • Place of Presentation
      大阪
    • Year and Date
      2009-03-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] Caspase 3-dependent Neural Cell Apoptosis and Telomere-dependent Senescence are Activated in the Cortex and Brainstem in Dietary-induced Obesity Rat2009

    • Author(s)
      Kishi T, et al
    • Organizer
      第73回日本循環器学会学術集会総会
    • Place of Presentation
      大阪
    • Year and Date
      2009-03-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] Left Ventricular Hypertrophy Enhances the Expression of Mineralocorticoid Receptor and Epithelial Na Channels in the Brain and Leads to Salt-sensitive Sympathetic Hyperactivation and Left Ventricular Dysfunction.2009

    • Author(s)
      Ito K, et al
    • Organizer
      Scientific Sessions of the American Heart Association
    • Place of Presentation
      Orland
    • Related Report
      2009 Annual Research Report
  • [Presentation] Transcutaneous bionic baroreflex system is widely applicable for preventing severe orthostatic hypotension in patients with cervical cord injury.2008

    • Author(s)
      Yoshida M, Chishaki A, Murayama Y, Kimura S, Ando M, Saito T, Shiba K, Shiino T, Todaka K, Sunagawa K.
    • Organizer
      Scientific Sessions 2008 of the American Heart Association.
    • Place of Presentation
      New Orleans, U.S.A.
    • Year and Date
      2008-11-12
    • Related Report
      2010 Final Research Report
  • [Presentation] Transcutaneous bionic baroreflex system is widely applicable for preventing severe orthostatic hypotension in patients with cervical cord injury2008

    • Author(s)
      Yoshida M, Chishaki A, Murayama Y, Kimura S, Ando M, Saito T, Shiba K, Shiino T, Todaka K, Sunagawa K.
    • Organizer
      Scientific Sessions 2008 of the American Heart Association
    • Place of Presentation
      Orland, U.S.A.
    • Year and Date
      2008-11-12
    • Related Report
      2008 Self-evaluation Report
  • [Presentation] Transcutaneous bionic baroreflex system is widely applicable for preventing severe orthostatic hypotension in patients with cervical cordinjury2008

    • Author(s)
      Yoshida M, et al
    • Organizer
      Scientific Sessions 2008 of the American Heart Association
    • Place of Presentation
      Orland, U.S.A.
    • Year and Date
      2008-11-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] Telmisartan Manifests Powerful Anti-inflammatory Effects Beyond Class Effects of Angiotensin II Type 1 Blocker by Inhibiting Tumor Necrosis Factor alpha-Induced Interleukin 6 Expressions through Peroxisome Proliferator Activated Receptory Activation.2008

    • Author(s)
      Ichiki T, et al
    • Organizer
      Scientific Sessions 2008 of the American Heart Association
    • Place of Presentation
      Orland, U.S.A.
    • Year and Date
      2008-11-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] Overexpression of Twinkle, a Mitochondria DNA Helicase, Ameliorates Cardiac Remodeling and Failure in Mice.2008

    • Author(s)
      Inoue T, et al
    • Organizer
      Scientific Sessions 2008 of the American Heart Association
    • Place of Presentation
      Orland, U.S.A.
    • Year and Date
      2008-11-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] Ras/Raf/p38 MAPK/ERK pathway is activated in the rostral ventrolateral medulla of stroke-prone spontaneously hypertensive rats2008

    • Author(s)
      Kishi T, et al
    • Organizer
      Scientific Sessions 2008 of the American Heart Association
    • Place of Presentation
      Orland, U.S.A.
    • Year and Date
      2008-11-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] High-salt intake superimposed on left ventricular hypertrophy activates brain ENaC and leads to sympathetic hyperactivation and ventricular dysfunction2008

    • Author(s)
      Ito K, et al
    • Organizer
      Scientific Sessions 2008 of the American Heart Association
    • Place of Presentation
      Orland, U.S.A.
    • Year and Date
      2008-11-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] Overexpression Of Mitochondrial Transcription Factor A Protects Failing Myocardium From Oxidative Stress2008

    • Author(s)
      Yoshida M, et al
    • Organizer
      Scientific Sessions 2008 of the American Heart Association
    • Place of Presentation
      Orland, U.S.A.
    • Year and Date
      2008-11-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] Intelligent neural regulation in managing cardiovascular diseases.2008

    • Author(s)
      Sunagawa K.
    • Organizer
      18th Meeting of the Cardiovascular System Dynamics Society.
    • Place of Presentation
      Atlanta, U.S.A.
    • Year and Date
      2008-09-28
    • Related Report
      2010 Final Research Report
  • [Presentation] Intelligent neural regulation in managing cardiovascular diseases2008

    • Author(s)
      Sunagawa K.
    • Organizer
      18th Meeting of the Cardiovascular System Dynamics Society
    • Place of Presentation
      Atlanta, U.S.A.
    • Year and Date
      2008-09-28
    • Related Report
      2008 Self-evaluation Report
  • [Presentation] Intelligent neural regulation in managing cardiovascular diseases.2008

    • Author(s)
      Sunagawa K.
    • Organizer
      XVIIIth Meeting of the Cardiovascular System Dynamics Society
    • Place of Presentation
      Atlanta, U.S.A.
    • Year and Date
      2008-09-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] Neural apoptosis in the vasomotor center of brainstem impairs baroreflex sensitivity in hypertensive rats.2008

    • Author(s)
      Kishi T, et al
    • Organizer
      XVIIIth Meeting of the Cardiovascular System Dynamics Society
    • Place of Presentation
      Atlanta, U.S.A.
    • Year and Date
      2008-09-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] Noninvasive Transcutaneous Bionic Baroreflex System Prevents Severe Orthostatic Hypotension in Patients with Spinal Cord Injury.2008

    • Author(s)
      Yoshida M, Murayama Y, Chishaki A, Sunagawa K.
    • Organizer
      30^<th> Annual International Conference of the IEEE Engineering in Medicine and Biology Society.
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2008-08-22
    • Related Report
      2010 Final Research Report
  • [Presentation] Noninvasive Transcutaneous Bionic Baroreflex System Prevents Severe Orthostatic Hypotension in Patients with Spinal Cord Injury2008

    • Author(s)
      Yoshida M, Murayama Y, Chishaki A, Sunagawa K.
    • Organizer
      30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2008-08-22
    • Related Report
      2008 Self-evaluation Report
  • [Presentation] Noninvasive Transcutaneous Bionic Baroreflex System Prevents Severe Orthostatic Hypotension in Patients with Spinal Cord Injury2008

    • Author(s)
      Yoshida M, et al
    • Organizer
      30^<th> Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2008-08-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] Sympatho-inhibitory effect of atorvastatin due to anti-senescence and attenuation of impaired neurogenesis in RVLM of SHRSP2008

    • Author(s)
      Kishi T, et al
    • Organizer
      Experimental Biology 2008
    • Place of Presentation
      San Diego, U.S.A.
    • Year and Date
      2008-04-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] Azelnidipine inhibits the sympathetic nerve activity and improves baroreflex control of heart rate via anti-oxidant effect in the rostral ventrolateral medulla.2008

    • Author(s)
      Konno S, et al
    • Organizer
      Experimental Biology 2008
    • Place of Presentation
      San Diego, U.S.A.
    • Year and Date
      2008-04-08
    • Related Report
      2008 Annual Research Report
  • [Presentation] Rinin-angiotensin system and NAD(P)H oxidase activation in the rostral ventrolateral medulla are involved in the further blood pressure elevation on high sodium diet in spontaneously hypertensive rats.2008

    • Author(s)
      Koga Y, et al
    • Organizer
      Experimental Biology 2008
    • Place of Presentation
      San Diego, U.S.A.
    • Year and Date
      2008-04-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] High salt intake deteriorates cardiac function of hypertrophied heart, possibly via excessive sympathetic drive.2008

    • Author(s)
      Ito K, et al
    • Organizer
      Experimental Biology 2008
    • Place of Presentation
      San Diego, U.S.A.
    • Year and Date
      2008-04-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] Impaired neurogenesis and activated caspase 3-dependent apoptosis pathway in the rostral ventrolateral medulla causes hypertension instroke-prone spontaneously hypertensive rats2008

    • Author(s)
      Kishi T, et al
    • Organizer
      Experimental Biology 2008
    • Place of Presentation
      San Diego, U.S.A.
    • Year and Date
      2008-04-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] Noninvasive Transcutaneous Bionic Baroreflex System Prevents Severe Orthostatic Hypotension in patients with Spinal Cord Injury.2008

    • Author(s)
      Yoshida M, Chishaki A, Saito T, Kimura S, Ando M, Tsutsumi T, Shiba K, Murayama Y, Sunagawa K.
    • Organizer
      Experimental Biology 2008.
    • Place of Presentation
      San Diego, U.S.A.
    • Year and Date
      2008-04-06
    • Related Report
      2010 Final Research Report
  • [Presentation] Autonomic modulation by vagus nerve stimulation in heart failure.2008

    • Author(s)
      Sunagawa K.
    • Organizer
      Experimental Biology 2008.
    • Place of Presentation
      San Diego, U.S.A.
    • Year and Date
      2008-04-06
    • Related Report
      2010 Final Research Report
  • [Presentation] Noninvasive Transcutaneous Bionic Baroreflex System Prevents Severe Orthostatic Hypotension in patients with Spinal Cord Injury2008

    • Author(s)
      Yoshida M, Chishaki A, Saito T, Kimura S, Ando M, Tsutsumi T, Shiba K, Murayama Y, Sunagawa K.
    • Organizer
      Experimental Biology2008
    • Place of Presentation
      San Diego, U.S.A.
    • Year and Date
      2008-04-06
    • Related Report
      2008 Self-evaluation Report
  • [Presentation] Autonomic modulation by vagus nerve stimulation in heart failure2008

    • Author(s)
      Sunagawa K.
    • Organizer
      Experimental Biology 2008
    • Place of Presentation
      San Diego, U.S.A.
    • Year and Date
      2008-04-06
    • Related Report
      2008 Self-evaluation Report
  • [Presentation] Olmesartan reduces oxidative stress in the brains of stroke-prone spontaneously hypertensive rats as measured by an in vivo ESR method.2008

    • Author(s)
      Araki S, et al
    • Organizer
      Experimental Biology 2008
    • Place of Presentation
      San Diego, U.S.A.
    • Year and Date
      2008-04-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] Noninvasive Transcutaneous Bionic Baroreflex System Prevents Severe Orthostatic Hypotension in patients with Spinal Cord Injury.2008

    • Author(s)
      Yoshida M, et al
    • Organizer
      Experimental Biology 2008
    • Place of Presentation
      San Diego, U.S.A.
    • Year and Date
      2008-04-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] Impaired neurogenesis in the rostral ventrolateral medulla causes hypertension in stroke-prone spontaneously hypertensive rats.2007

    • Author(s)
      Kishi T, Hirooka Y, Sunagawa K.
    • Organizer
      Heart Association.
    • Place of Presentation
      Orland, U.S.A.
    • Year and Date
      2007-11-07
    • Related Report
      2010 Final Research Report
  • [Presentation] High salt diet exacerbates hypertension via increased oxidative stress in the rostral ventrolateral medulla and sympathetic hyperactivity in spontaneously hypertensive rats.2007

    • Author(s)
      Koga Y, Hirooka Y, Araki S, Nozoe M, Kishi T, Sunagawa K.
    • Organizer
      Heart Association.
    • Place of Presentation
      Orland, U.S.A.
    • Year and Date
      2007-11-07
    • Related Report
      2010 Final Research Report
  • [Presentation] Modulation of the myocardial redox state by vagal nerve stimulation after experimental myocardial infarction.2007

    • Author(s)
      Tsutsumi T, Ide T, Yamato M, Kudou W, Andou M, Hirooka Y, Utsumi H, Tsutsui H, Sunagawa K.
    • Organizer
      Heart Association.
    • Place of Presentation
      Orland, U.S.A.
    • Year and Date
      2007-11-07
    • Related Report
      2010 Final Research Report
  • [Presentation] Vagal Stimulation Suppresses Reactive Oxygen Species (ROS)in the Failing Myocardium in Mice2007

    • Author(s)
      Tsutsumi T, et. al.
    • Organizer
      American Heart Association Scientific Session 2007
    • Place of Presentation
      Orland(U.S.A.)
    • Year and Date
      2007-11-07
    • Related Report
      2007 Annual Research Report
  • [Presentation] High Salt Diet Exacerbates Hypertension via Increased Oxidative Stress in the Rostral Ventrolateral Medulla and Sympathetic Hyperactivity in Spontaneously Hypertensive Rats2007

    • Author(s)
      Koga Y, et. al.
    • Organizer
      American Heart Association Scientific Session 2007
    • Place of Presentation
      Orland(U.S.A.)
    • Year and Date
      2007-11-07
    • Related Report
      2007 Annual Research Report
  • [Presentation] Noninvasive Transcutaneous Bionic Baroreflex System2007

    • Author(s)
      Yoshida M, et. al.
    • Organizer
      American Heart Association Scientific Session 2007
    • Place of Presentation
      Orland(U.S.A.)
    • Year and Date
      2007-11-07
    • Related Report
      2007 Annual Research Report
  • [Presentation] Impaired Neurogenesis in the Rostral Ventrolateral Medulla Cause Hypertension in Stroke-prone Spontaneously Hypertensive Rats2007

    • Author(s)
      Kishi T, et. al.
    • Organizer
      AmericanHeart AssociationScientificSession2007
    • Place of Presentation
      Orland(U.S.A.)
    • Year and Date
      2007-11-07
    • Related Report
      2007 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.med.kyushu-u.ac.jp/cardiol/kyoshitsu/baio/index.html

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.med.kyushu-u.ac.jp/cardiol/kyoshitsu/baio/index.html

    • Related Report
      2008 Self-evaluation Report
  • [Patent(Industrial Property Rights)] Bionic baroreflex system to treat heart failure with preserved ejection fraction2010

    • Inventor(s)
      Sunagawa K, et al
    • Industrial Property Rights Holder
      九州大学
    • Filing Date
      2010-09-21
    • Related Report
      2010 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] Cardiovascular disease therapy device2009

    • Inventor(s)
      砂川賢二
    • Industrial Property Rights Holder
      九州大学
    • Filing Date
      2009-03-19
    • Related Report
      2008 Self-evaluation Report
    • Overseas
  • [Patent(Industrial Property Rights)] Cardiovascular disease therapy device2009

    • Inventor(s)
      Sunagawa K, et al
    • Industrial Property Rights Holder
      九州大学
    • Filing Date
      2009-03-19
    • Related Report
      2008 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 経皮的電気刺激による血圧安定化システム2008

    • Inventor(s)
      砂川賢二
    • Industrial Property Rights Holder
      九州大学
    • Filing Date
      2008-10-15
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 経皮的電気刺激による血圧安定化システム2008

    • Inventor(s)
      砂川賢二
    • Industrial Property Rights Holder
      九州大学
    • Filing Date
      2008-10-15
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 経皮的電気刺激による血圧安定化システム2008

    • Inventor(s)
      砂川賢二
    • Industrial Property Rights Holder
      九州大学
    • Filing Date
      2008-10-15
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 経皮的電気刺激による血圧安定化システム2008

    • Inventor(s)
      砂川賢二
    • Industrial Property Rights Holder
      九州大学
    • Filing Date
      2008-10-15
    • Related Report
      2008 Self-evaluation Report
    • Overseas
  • [Patent(Industrial Property Rights)] 経皮的電気刺激による血圧安定化システム2008

    • Inventor(s)
      砂川賢二
    • Industrial Property Rights Holder
      九州大学
    • Filing Date
      2008-10-15
    • Related Report
      2008 Self-evaluation Report
  • [Patent(Industrial Property Rights)] 経皮的電気刺激による血圧安定化システム2008

    • Inventor(s)
      砂川賢二, 他
    • Industrial Property Rights Holder
      九州大学
    • Filing Date
      2008-10-15
    • Related Report
      2008 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 経皮的電気刺激による血圧安定化システム2008

    • Inventor(s)
      砂川賢二, 他
    • Industrial Property Rights Holder
      九州大学
    • Filing Date
      2008-10-15
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 経皮的電気刺激による血圧定化システム2007

    • Inventor(s)
      砂川 賢二
    • Industrial Property Rights Holder
      砂川 賢二
    • Filing Date
      2007-10-15
    • Related Report
      2007 Annual Research Report
    • Overseas

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Published: 2006-04-01   Modified: 2016-04-21  

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