Explorations into development of bionic baroreflex system to overcome arterial pressure dysregulation in patients with cervical cord injury

• Project/Area Number: 18100006
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Kyushu University
• Principal Investigator: SUNAGAWA Kenji Kyushu University, 医学研究院, 教授 (50163043)
• Co-Investigator(Kenkyū-buntansha): HIROOKA Yoshitaka 九州大学, 大学病院, 講師 (90284497) ; TODAKA Koji 九州大学, 大学病院, 特任准教授 (40398061) ; CHISYAKI Akiko 九州大学, 医学研究院, 教授 (60216497) ; 川田 徹 国立循環器病センター研究所, 循環動態機能部, 室長 (30243752)
• Co-Investigator(Renkei-kenkyūsha): KAWADA Toru 国立循環器病研究センター, 研究所, 室長 (30243752)
• Project Period (FY): 2006 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥110,110,000 (Direct Cost: ¥84,700,000、Indirect Cost: ¥25,410,000); Fiscal Year 2010: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000); Fiscal Year 2009: ¥21,580,000 (Direct Cost: ¥16,600,000、Indirect Cost: ¥4,980,000); Fiscal Year 2008: ¥21,580,000 (Direct Cost: ¥16,600,000、Indirect Cost: ¥4,980,000); Fiscal Year 2007: ¥21,580,000 (Direct Cost: ¥16,600,000、Indirect Cost: ¥4,980,000); Fiscal Year 2006: ¥34,580,000 (Direct Cost: ¥26,600,000、Indirect Cost: ¥7,980,000)
• Keywords: バイオニック医学 / 血圧制御 / 脊髄損傷 / 自動治療 / 生体医工学

Research Abstract

Central baroreflex failure in spinal cord injuries results in serious orthostatic hypotension. Even the latest medical science fails to provide a fundamental remedy for those patients. Since somatic inputs affect sympathetic activities, we examined if transcutaneous electrical stimulation can feedback control arterial pressure (bionic baroreflex system) in spinalized patients. We identified skin regions capable of increasing arterial pressure in response to electrical stimulation. We then determined the transfer function from the stimulation to arterial pressure responses and developed the bionic baroreflex system. The bionic baroreflex system fully prevented orthostatic hypotension in patients with spinal cord injuries.

Research Products

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  • Journal Title: Am J Physiol Regul Integr Comp Physiol. 300
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• [Journal Article] Nanoparticle-mediated delivery of pitavastatin into lungs ameliorates the development and induces regression of monocrotaline-induced pulmonary artery hypertension. (2011)
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  • Journal Title: Hypertension. 55 Pages: 291-297
• [Journal Article] Baroreflex sensitivity might predict responders to milrinone in patients with heart failure. (2010)
  • Author(s): Kishi T, Sunagawa K.
  • Journal Title: Int Heart J Volume: 51 Pages: 411-415
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• [Journal Article] Para-Hisian pacing for a pediatric patient with a congenitally corrected transposition of the great arteries (SLL). (2010)
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  • Journal Title: Pacing Clin Electrophysiol. Volume: 33
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• [Journal Article] Sympathoinhibition induced by centrally administered atorvastatin is associated with alteration of NAD(P)H and Mn superoxide dismutase activity in rostral ventrolateral medulla of stroke-prone spontaneously hypertensive rats. (2010)
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• [Journal Article] Cross-sectional characterization of all classes of antihypertensives in terms of central blood pressure in Japanese hypertensive patients. (2010)
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• [Journal Article] Angiotensin II type 1 receptor-activated caspase-3 through ras/mitogen-activated protein kinase/extracellular signal-regulated kinase in the rostral ventrolateral medulla is involved in sympathoexcitation in stroke-prone spontaneously hypertensive rats. (2010)
  • Author(s): Kishi T, et al
  • Journal Title: Hypertension Volume: 55 Pages: 291-297
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• [Journal Article] Nanoparticle-mediated endothelial cell-selective delivery of pitavastatin induces functional collateral arteries (therapeutic arteriogenesis) in a rabbit model of chronic hind limb ischemia. (2010)
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• [Journal Article] Blockade of mineralocorticoid receptors improves salt-induced left-ventricular systolic dysfunction through attenuation of enhanced sympathetic drive in mice with pressure overload. (2010)
  • Author(s): Ito K, Hirooka Y, Sunagawa K
  • Journal Title: J Hypertens. Volume: 28 Pages: 1449-1458
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• [Journal Article] Acetylcholinesterase inhibitors attenuate atherogenesis in apolipoprotein E-knockout mice. (2010)
  • Author(s): Inanaga K, et al
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• [Journal Article] Oxidative stress and central cardiovascular regulation.-Pathogenesis of hypertension and therapeutic aspects. (2010)
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• [Journal Article] Angiotensin II type 1 receptor-activated caspase-3 throughras/mitogen-activated protein kinase/extracellular signal-regulated kinase in the rostral ventrolateral medulla is involved in sympathoexcitation in stroke-prone spontaneously hypertensive rats. (2010)
  • Author(s): Kishi T, et al
  • Journal Title: Hypertension 55 Pages: 291-297
  • Peer Reviewed
• [Journal Article] Sympathoinhibition induced by centrally administered atorvastatin is associated with alteration of NAD(P)H and Mn superoxide dismutase activity in rostral ventrolateral medulla of stroke-prone spontaneously hypertensive rats. (2010)
  • Author(s): Kishi T, et al
  • Journal Title: J Cardiovasc Pharmacol. 55 Pages: 184-190
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• [Journal Article] Para-Hisian Pacing for a Pediatric Patient with a Congenitally Corrected Transposition of the Great Arteries(SLL). (2010)
  • Author(s): Takemoto M, et al
  • Journal Title: Pacing Clin Electrophysiol. 33
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• [Journal Article] Bionic cardiology : exploration into a wealth of controllable body parts in the cardiovascular system. (2009)
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• [Journal Article] Acquisition of Brain Na Sensitivity Contributes to Salt-Induced Sympathoexcitation and Cardiac Dysfunction in Mice With Pressure Overload. (2009)
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  • Journal Title: Circ Res. 104 Pages: 1004-1011
• [Journal Article] Servo-Controlled Hind-Limb Electrical Stimulation for Short-Term Arterial Pressure Control. (2009)
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• [Journal Article] Atorvastatin improves the impaired baroreflex sensitivity via anti-oxidant effect in the rostral ventrolateral medulla of SHRSP. (2009)
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• [Journal Article] Olmesartan reduces oxidative stress in the brain of stroke-prone spontaneously hypertensive rats assessed by an in vivo ESR method. (2009)
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• [Journal Article] Inhibition of prolyl hydroxylase domain-containing protein suppressed lipopolysaccharide-induced TNF-alpha expression. (2009)
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• [Journal Article] Coronary aneurysm associated with coronary perforation after sirolimus-eluting stents implantation : Close follow-up exceeding 2 years by coronary 3-dimensional computed tomography. (2009)
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• [Journal Article] Role of inducible nitric oxide synthase in rostral ventrolateral medulla in blood pressure regulation in spontaneously hypertensive rats. (2009)
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• [Journal Article] Cilnidipine inhibits the sympathetic nerve activity and improves baroreflex sensitivity in patients with hypertension. (2009)
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• [Journal Article] Resveratrol attenuates angiotensin II-induced interleukin-6 expression and perivascular fibrosis. (2009)
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• [Journal Article] Nanoparticle-mediated delivery of nuclear factor kappaB decoy into lungs ameliorates monocrotaline-induced pulmonary arterial hypertension. (2009)
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  • Journal Title: Hypertension. 53 Pages: 877-883
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• [Journal Article] Acquisition of brain Na sensitivity contributes to salt-induced sympathoexcitation and cardiac dysfunction in mice with pressure overload. (2009)
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• [Journal Article] Servo-controlled hind-limb electrical stimulation for short-term arterial pressure control. (2009)
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• [Journal Article] Computationally managed bradycardia improved cardiac energetics while restoring normal hemodynamics in heart failure. (2009)
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• [Journal Article] Wavelet-based system identification of short-term dynamic characteristics of arterial baroreflex. (2009)
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  • Journal Title: Ann Biomed Eng. 37 Pages: 112-128
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• [Journal Article] Acquisition of Brain Na Sensitivity Contributes to Salt-Induced Sympathoexcitation and Cardiac Dysfunction in Mice With Pressure Overload (2009)
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  • Journal Title: Circ Res (In press)
• [Journal Article] Servo-Controlled Hind-Limb Electrical Stimulation for Short-Term Arterial Pressure Control (2009)
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  • Journal Title: Circ J. (In press)
• [Journal Article] Therapeutic Neovascularization by Nanotechnology-Mediated Cell-Selective Delivery of Pitavastatin Into the Vascular Endothelium. (2009)
  • Author(s): Kubo M, et al
  • Journal Title: Arterioscler Thromb Vase Biol. (In press)
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• [Journal Article] Nanoparticle-Mediated Delivery of Nuclear Factor κB Decoy Into Lungs Ameliorates Monocrotaline-Induced Pulmonary Arterial Hypertension. (2009)
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  • Journal Title: Hypertension. (In press)
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• [Journal Article] Acquisition of Brain Na Sensitivity Contributes to Salt-Induced Sympathoexcitation and Cardiac Dysfunction in Mice With Pressure Overload. (2009)
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  • Journal Title: Circ Res. (In press)
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• [Journal Article] Servo-Controlled Hind-Limb Electrical Stimulation for Short-Term Arterial Pressure Control. (2009)
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  • Journal Title: Circ J. (In press)
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• [Journal Article] Inhibition of Tumor Necrosis Factor-α-Induced Interleukin-6 Expression by Telmisartan Through Cross-Talk of Peroxisome Proliferator-Activated Receptor-γ With Nuclear Factor κB and CCAAT/Enhancer-Binding Protein-β. (2009)
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  • Journal Title: Hypertension. (In press)
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• [Journal Article] Time-dependent changes of myocardial and systemic oxidative stress are dissociated after myocardial infarction. (2009)
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• [Journal Article] Soluble Flt-1 gene transfer ameliorates neointima formation after wireinjury in fit-1 tyrosine kinase-deficient mice. (2009)
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• [Journal Article] Muscle mechanoreflex augments arterial baroreflex-mediated dynamic sympathetic response to carotid sinus pressure. (2008)
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  • Journal Title: Am J Physiol Heart Circ Physiol. 295
• [Journal Article] Modulation of the myocardial redox state by vagal nerve stimulation after experimental myocardial infarction. (2008)
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  • Journal Title: Cardiovasc Res. 77 Pages: 713-721
• [Journal Article] Muscle mechanoreflex augments baroreflex-mediated dynamic sympathetic response to carotid sinus pressure (2008)
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  • Journal Title: Am J Physiol Heart Circ Physiol 295
• [Journal Article] Modulation of the myocardial redox state by vagal nerve stimulation after experimental myocardial infarction (2008)
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• [Journal Article] Atorvastatin reduces oxidative stress in the rostral ventrolateral medulla of stroke-prone spontaneously hypertensive rats. (2008)
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• [Journal Article] Involvement of Mstl in tumor necrosis factor-alpha-induced apoptosis of endothelial cells (2008)
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• [Journal Article] Modulation of the myocardial redox state by vagal nerve stimulation after experimental myocardial infarction (2008)
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• [Journal Article] Long-acting calcium channel blocker, azelnidipine, increases endothelial nitric oxide synthase in the brain and inhibits sympathetic nerve activity. (2007)
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• [Journal Article] Short-term electroacupuncture at Zusanli resets the arterial baroreflex neural arc toward lower sympathetic nerve activity. (2006)
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• [Journal Article] Short-term electroacupuncture at Zusanli resets the arterial baroreflex neural arc toward lower sympathetic nerve activity (2006)
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  • Author(s): Ohtani K, Egashira K, Ihara Y, Nakano K, FUnakoshi K, Zhao G, Sata M, Sunagawa K.
  • Journal Title: Hypertension 48 Pages: 664-670
• [Journal Article] Telmisartan downregulates angiotensin II type 1 receptor through activation of peroxisome proliferator-activated receptor gamma. (2006)
  • Author(s): Imayama I, Ichiki T, Inanaga K, Ohtsubo H, Fukuyama K, Ono H, Hashiguchi Y, Sunagawa K.
  • Journal Title: Cardiovasc Res. 72 Pages: 184-190
• [Journal Article] Reversible vagal blockade in conscious rats using a targeted delivery device. (2006)
  • Author(s): Zheng C, Kawada T, Li M, Sato T, Sunagawa K, Sugimachi M.
  • Journal Title: J Neurosci Methods. 156 Pages: 71-75
• [Journal Article] Automated drug delivery system to control systemic arterial pressure, cardiac output, and left heart filling pressure in acute decompensated heart failure. (2006)
  • Author(s): Uemura K, Kamiya A, Hidaka I, Kawada T, Shimizu S, Shishido T, Yoshizawa M, Sugimachi M, Sunagawa K.
  • Journal Title: J Appl Physiol. 100 Pages: 1278-1286
• [Journal Article] Peak Systolic Mitral Annulus Velocity Reflects the Status of Ventricular-Arterial Coupling-Theoretical and Experimental Analyses.
  • Author(s): Uemura K, et al
  • Journal Title: J Am Soc Echocardiogr Volume: (In press)
  • Peer Reviewed
• [Presentation] NPC1L1 Inhibition with Ezetimibe Suppresses Enhanced Formation of Aortic Atherosclerosis Induced by Dietary Cholesterol Oxidation Products in ApoE-deficient Mice (2010)
  • Author(s): Sato K, et al
  • Organizer: Scientific Sessions 2010, American Heart Association
  • Place of Presentation: Chicago, U.S.A.
  • Year and Date: 2010-11-17
• [Presentation] Nanoparticle-mediated Endothelial Cell-selective Delivery of Pioglitazone Enhances Therapeutic Efficacy of Therapeutic Angiogenesis and Arteriogenesis after Hindlimb Ischemia in Mice (2010)
  • Author(s): Nagahama R, et al
  • Organizer: Scientific Sessions 2010, American Heart Association
  • Place of Presentation: Chicago, U.S.A.
  • Year and Date: 2010-11-16
• [Presentation] Nanoparticle-Mediated Monocyte-Selective Delivery of Pitavastatin Prevents Angiotensin II-Induced Abdominal Aortic Aneurysm Formation in ApoE-Deficient Mice (2010)
  • Author(s): Katsuki S, et al
  • Organizer: Scientific Sessions 2010, American Heart Association
  • Place of Presentation: Chicago, U.S.A.
  • Year and Date: 2010-11-16
• [Presentation] AT_1 Receptor-Activated Toll-Like Receptor 4 in the Brainstem Causes Sympathoexcitation in Mice With Heart Failure (2010)
  • Author(s): Ogawa K, et al
  • Organizer: Scientific Sessions 2010, American Heart Association
  • Place of Presentation: Chicago, U.S.A.
  • Year and Date: 2010-11-16
• [Presentation] Endogenous Angiotensin-(1-7) Activity in the Rostral Ventrolateral Medulla Is Enhanced in Spontaneously Hypertensive Rats via Sympathetic Nerve Activity (2010)
  • Author(s): Nakagaki T, et al
  • Organizer: Scientific Sessions 2010, American Heart Association
  • Place of Presentation: Chicago, U.S.A.
  • Year and Date: 2010-11-16
• [Presentation] Nanoparticle-Mediated Monocyte-Selective Delivery of Pitavastatin Inhibits Monocyte Activation and Attenuates Plaque Destabilization and Rupture in ApoE-Deficient Mice (2010)
  • Author(s): Katsuki S, et al
  • Organizer: Scientific Sessions 2010, American Heart Association
  • Place of Presentation: Chicago, U.S.A.
  • Year and Date: 2010-11-15
• [Presentation] Dentification of Rho-associated Kinase 2 (ROCK2) as a Key Molecule Generating the Intrinsic Circadian Rhythm of Vascular Contractility (2010)
  • Author(s): Saito T, et al
  • Organizer: Scientific Sessions 2010, American Heart Association
  • Place of Presentation: Chicago, U.S.A.
  • Year and Date: 2010-11-15
• [Presentation] Neuregulin-1/ErbB Pathway Modulation of Major Neurotransmitters in the Cardiovascular Center is Crucial for Neural Regulation of Blood Pressure -Possible Involvement of Neuregulin-1/ErbB Pathway in Neural Mechanisms of Hypertension- (2010)
  • Author(s): Matsukawa R, et al
  • Organizer: Scientific Sessions 2010, American Heart Association
  • Place of Presentation: Chicago, U.S.A.
  • Year and Date: 2010-11-15
• [Presentation] Reactive Oxygen Species in Rostral Ventrolateral Medulla Contribute to Neural Mechanisms of Hypertension by Modulating Paraventricular Nucleus of Hypothalamus (2010)
  • Author(s): Nishihara M, et al
  • Organizer: Scientific Sessions 2010, American Heart Association
  • Place of Presentation: Chicago, U.S.A.
  • Year and Date: 2010-11-15
• [Presentation] NPC1L1 Inhibition with Ezetimibe Prevents Accelerated Plaque Destabilization and Rupture Induced by Dietary Cholesterol Oxidation Products in ApoE-deficient Mice (2010)
  • Author(s): Sato K, et al
  • Organizer: Scientific Sessions 2010, American Heart Association
  • Place of Presentation: Chicago, U.S.A.
  • Year and Date: 2010-11-14
• [Presentation] Baroreflex failure makes patients super susceptible to volume overload and predisposes patients to pulmonary edema in the absence of left ventricular systolic failure. (2010)
  • Author(s): Sunagawa K.
  • Organizer: 21th International Symposium on the autonomic nervous system.
  • Place of Presentation: Orland, U.S.A.
  • Year and Date: 2010-11-05
• [Presentation] Baroreflex regulates arterial pressure by modulating vascular properties, not by modulating ventricular properties. (2010)
  • Author(s): Sunagawa K.
  • Organizer: 21th International Symposium on the autonomic nervous system.
  • Place of Presentation: Orland, U.S.A.
  • Year and Date: 2010-11-05
• [Presentation] Baroreflex failure makes patients super susceptible to volume overload and predisposes patients to pulmonary edema in the absence of left ventricular systolic failure. (2010)
  • Author(s): Sunagawa K.
  • Organizer: 21^<th> International Symposium on the autonomic nervous system
  • Place of Presentation: Florida, U.S.A.
  • Year and Date: 2010-11-05
• [Presentation] Baroreflex regulates arterial pressure by modulating vascular properties, not by modulating ventricular properties. (2010)
  • Author(s): Sunagawa K.
  • Organizer: 21^<th> International Symposium on the autonomic nervous system
  • Place of Presentation: Florida, U.S.A.
  • Year and Date: 2010-11-05
• [Presentation] Estimated Venous Return Surface and Cardiac Output Curve Precisely Predicts New Hemodynamics after Volume Change. (2010)
  • Author(s): Sugimachi M, Sunagawa K, Uemura K, Kamiya A, Shimizu S, Inagaki M, Shishido T.
  • Organizer: IEEE Engineering in Medicine and Biology Society.
  • Place of Presentation: Buenos Aires, Argentina
  • Year and Date: 2010-09-03
• [Presentation] Automated Drug Delivery System for the Management of Hemodynamics and Cardiac Energetic in Acute Heart Failure. (2010)
  • Author(s): Uemura K, Sugimachi M, Kawada T, Sunagawa K.
  • Organizer: IEEE Engineering in Medicine and Biology Society.
  • Place of Presentation: Buenos Aires, Argentina
  • Year and Date: 2010-09-03
• [Presentation] Estimated Venous Return Surface and Cardiac Output Curve Precisely Predicts New Hemodynamics after Volume Change. (2010)
  • Author(s): Sugimachi M, et al
  • Organizer: 32^<nd> Annual International Conference of the IEEE Engineering in Medicine and Biology Society
  • Place of Presentation: Buenos Aires, Argentina
  • Year and Date: 2010-09-03
• [Presentation] Automated Drug Delivery System for the Management of Hemodynamics and Cardiac Energetic in Acute Heart Failure. (2010)
  • Author(s): Uemura K, et al
  • Organizer: 32^<nd> Annual International Conference of the IEEE Engineering in Medicine and Biology Society
  • Place of Presentation: Buenos Aires, Argentina
  • Year and Date: 2010-09-03
• [Presentation] Development of Artificial Bionic Baroreflex System. (2010)
  • Author(s): Sunagawa K, Sugimachi M.
  • Organizer: 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society.
  • Place of Presentation: Buenos Aires, Argentina
  • Year and Date: 2010-09-02
• [Presentation] How to quantitatively synthesize dynamic changes in arterial pressure from baroreflexly modulated ventricular and arterial properties. (2010)
  • Author(s): Sakamoto T, Murayama Y, Tobushi T, Sakamoto K, Tanaka A, Tsutsumi T, Sunagawa K.
  • Organizer: IEEE Engineering in Medicine and Biology Society.
  • Place of Presentation: Buenos Aires, Argentina
  • Year and Date: 2010-09-02
• [Presentation] Physiological Significance of Pressure-Volume Relationship : A Load-Independent Index and a Determinant of Pump Function. (2010)
  • Author(s): Sugimachi M, Sunagawa K, Uemura K, Shishido T.
  • Organizer: IEEE Engineering in Medicine and Biology Society.
  • Place of Presentation: Buenos Aires, Argentina
  • Year and Date: 2010-09-02
• [Presentation] The Pressure-Volume Relationship of the Heart : Past, Present and Future. (2010)
  • Author(s): Sunagawa K.
  • Organizer: IEEE Engineering in Medicine and Biology Society.
  • Place of Presentation: Buenos Aires, Argentina
  • Year and Date: 2010-09-02
• [Presentation] Development of Artificial Bionic Baroreflex System (2010)
  • Author(s): Sunagawa K.
  • Organizer: 32^<nd> Annual International Conference of the IEEE Engineering in Medicine and Biology Society
  • Place of Presentation: Buenos Aires, Argentina
  • Year and Date: 2010-09-02
• [Presentation] How to Quantitatively Synthesize Dynamic Changes in Arterial Pressure from Baroreflexly Modulated Ventricular and Arterial Properties. (2010)
  • Author(s): Sakamoto T, et al
  • Organizer: 32^<nd> Annual International Conference of the IEEE Engineering in Medicine and Biology Society
  • Place of Presentation: Buenos Aires, Argentina
  • Year and Date: 2010-09-02
• [Presentation] Physiological Significance of Pressure-Volume Relationship : A Load-Independent Index and a Determinant of Pump Function. (2010)
  • Author(s): Sugimachi M, et al
  • Organizer: 32^<nd> Annual International Conference of the IEEE Engineering in Medicine and Biology Society
  • Place of Presentation: Buenos Aires, Argentina
  • Year and Date: 2010-09-02
• [Presentation] The Pressure-Volume Relationship of the Heart : Past, Present and Future. (2010)
  • Author(s): Sunagawa K.
  • Organizer: 32^<nd> Annual International Conference of the IEEE Engineering in Medicine and Biology Society
  • Place of Presentation: Buenos Aires, Argentina
  • Year and Date: 2010-09-02
• [Presentation] (2010)
  • Author(s): Hosokawa K, Kawada T, Ando M, Tanaka A, Sakamoto T, Onitsuka K, Murayama Y, Ide T, Sunagawa K.
  • Organizer: Experimental Biology 2010.
  • Place of Presentation: Anaheim, U.S.A.
  • Year and Date: 2010-04-28
• [Presentation] Equilibrium analysis between the venous return surface and cardiac output curve enables us to predict hemodynamic impact of percutaneous cardiopulmonary support. (2010)
  • Author(s): Tanaka A, Sunagawa K.
  • Organizer: Experimental Biology 2010.
  • Place of Presentation: Anaheim, U.S.A.
  • Year and Date: 2010-04-28
• [Presentation] Electrical vagal afferent stimulation inhibits sympathetic nervous activity irrespective of baroreflex activation without lowering blood pressure. (2010)
  • Author(s): Hosokawa K, et al
  • Organizer: Experimental Biology 2010
  • Place of Presentation: Anaheim, U.S.A.
  • Year and Date: 2010-04-28
• [Presentation] Equilibrium analysis between the venous return surface and cardiac output curve enables us to predict hemodynamic impact of percutaneous cardiopulmonary support. (2010)
  • Author(s): Tanaka A, Sunagawa K
  • Organizer: Experimental Biology 2010
  • Place of Presentation: Anaheim, U.S.A.
  • Year and Date: 2010-04-28
• [Presentation] Telmisartan improves cognitive function through the increase in neurotrophic factor and inhibition of apoptosis in hippocampus of rats with metabolic syndrome. (2010)
  • Author(s): Kishi T, Hirooka Y, Sunagawa K.
  • Organizer: Experimental Biology 2010
  • Place of Presentation: Anaheim, U.S.A.
  • Year and Date: 2010-04-27
• [Presentation] Intrinsic circadian oscillation of myosin light chain phosphorylation in vascular smooth muscle cells. (2010)
  • Author(s): Saito T, et al
  • Organizer: Experimental Biology 2010
  • Place of Presentation: Anaheim, U.S.A.
  • Year and Date: 2010-04-27
• [Presentation] Reduced reactive oxgen species generation in rostral ventrolateral medulla suppresses the pressor response induced by the excitation of the paraventricular nucleus of the hypothalamus in spontaneously hypertensiverats. (2010)
  • Author(s): Nishihara M, et al
  • Organizer: Experimental Biology 2010
  • Place of Presentation: Anaheim, U.S.A.
  • Year and Date: 2010-04-27
• [Presentation] Telmisartan inhibits sympathetic nerve activity through the inhibition of oxidative stress and increase in NO and GABA in the brain of hypertensive rats. (2010)
  • Author(s): Kishi T, Hirooka Y, Sunagawa K.
  • Organizer: Experimental Biology 2010.
  • Place of Presentation: Anaheim, U.S.A.
  • Year and Date: 2010-04-26
• [Presentation] Angiotensin (1-7) into rostral ventrolateral medulla is enhanced in spontaneously hypertensive rats (2010)
  • Author(s): Nakagaki T, Hirooka Y, Ito K, Hoka S, Sunagawa K.
  • Organizer: Experimental Biology 2010.
  • Place of Presentation: Anaheim, U.S.A.
  • Year and Date: 2010-04-26
• [Presentation] Quantitative synthesis of dynamic baroreflex pressure regulation using baroreflex induced changes in ventricular and vascular properties. (2010)
  • Author(s): Sakamoto T, Tsutsumi T, Murayama Y, Tanaka A, Tobushi T, Sakamoto K, Sunagawa K.
  • Organizer: Experimental Biology 2010.
  • Place of Presentation: Anaheim, U.S.A.
  • Year and Date: 2010-04-26
• [Presentation] Quantitative synthesis of dynamic baroreflex pressure regulation using baroreflex induced changes in ventricular and vascular properties. (2010)
  • Author(s): Sakamoto T, et al
  • Organizer: Experimental Biology 2010
  • Place of Presentation: Anaheim, U.S.A.
  • Year and Date: 2010-04-26
• [Presentation] Telmisartan inhibits sympathetic nerve activity through the reduction of oxidative stress and release of GABA in RVLM of hypertensive rats. (2010)
  • Author(s): Kishi T, Hirooka Y, Sunagawa K.
  • Organizer: Experimental Biology 2010
  • Place of Presentation: Anaheim, U.S.A.
  • Year and Date: 2010-04-26
• [Presentation] Angiotensin (1-7) into rostral ventrolateral medulla is enhances in spontaneously hypertensive rats. (2010)
  • Author(s): Nakagaki T, et al
  • Organizer: Experimental Biology 2010
  • Place of Presentation: Anaheim, U.S.A.
  • Year and Date: 2010-04-26
• [Presentation] Neuregulin-1/erbB signaling in rostral ventrolateral medulla of brainstem is involves in blood pressure regulation alteration of major neurotransmitters. (2010)
  • Author(s): Matsukawa R, et al
  • Organizer: Experimental Biology 2010
  • Place of Presentation: Anaheim, U.S.A.
  • Year and Date: 2010-04-26
• [Presentation] Apoptosis of astrocyte mediated by Toll-like receptor 4 and apoptosis signal-regulating 1 in cardiovascular center causes excessive sympathoexcitation in hypertensive rats. (2010)
  • Author(s): Kishi T, et al
  • Organizer: Experimental Biology 2010
  • Place of Presentation: Anaheim, U.S.A.
  • Year and Date: 2010-04-26
• [Presentation] Toll-like receptor expression is increased via activation of AT1 receptor in the brain associated with sympathoexcitation in mice with heart failure. (2010)
  • Author(s): Ogawa K, et al
  • Organizer: Experimental Biology 2010
  • Place of Presentation: Anaheim, U.S.A.
  • Year and Date: 2010-04-26
• [Presentation] Vagal Nerve Stimulation during Ischemia-Reperfusion(I/R)Reduces the Infarct Size and Ameliorates Subsequent Left Ventricular(LV)Dysfunction/Remodeling (2010)
  • Author(s): Ando M, et al
  • Organizer: 第74回日本循環器学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2010-03-07
• [Presentation] Arterial Pressure Destabilization in Patients with Cervical Spinal Cord Injury Requires Tailored Therapeutic Strategies Depending upon the Post Injury Period (2010)
  • Author(s): Sakamoto T, et al
  • Organizer: 第74回日本循環器学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2010-03-07
• [Presentation] Decreases in Brain Sigma-1 Receptor Contribute to Sympathetic Hyperactivation in Mice with Heart Failure. (2010)
  • Author(s): Ito K, et al
  • Organizer: 第74回日本循環器学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2010-03-07
• [Presentation] Telmisartan Improves Endothelial Function and Decreases Sympathetic Nerve Activity to a Greater Extent than Candesartan in Patients with Metabolic Syndrome (2010)
  • Author(s): Kishi T, et al
  • Organizer: 第74回日本循環器学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2010-03-07
• [Presentation] Apoptosis of Astrocyte Mediated by Toll-like Receptor 4 and Apoptosis Signal-Regulating 1 in Cardiovascular Center Causes Sympathoexcitation in Hypertensive Rats (2010)
  • Author(s): Kishi T, et al
  • Organizer: 第74回日本循環器学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2010-03-07
• [Presentation] Electrical Afferent Vagal Stimulation Markedly Inhibits Sympathetic Nervous Activity Irrespective of Baroreflex Activation without Lowering Blood Pressure. (2010)
  • Author(s): Hosokawa K, et al.
  • Organizer: 第74回日本循環器学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2010-03-06
• [Presentation] Sildenafil Improves Exercise Tolerance in Patients with Refractory Heart Failure through Ameliorating Right Ventricular Afterload Mismatch (2010)
  • Author(s): Sakamoto T, et al
  • Organizer: 第74回日本循環器学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2010-03-06
• [Presentation] AT1 Receptor-activated Ras-induced Apoptosis and P53-induced Senescence in the Cardiovascular Center of Brainstem Contributes to Sympathoexcitaion of Hypertensive Rats. (2010)
  • Author(s): Kishi T, et al
  • Organizer: 第74回日本循環器学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2010-03-06
• [Presentation] Neuregulin-1/erbB Signaling in the Rostral Ventrolateral Medulla(RVLM)of Brainstem Contributes to Neural Regulation of Blood Pressure. (2010)
  • Author(s): Matsukawa R, et al
  • Organizer: 第74回日本循環器学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2010-03-06
• [Presentation] Reduction of ErbB receptors in the Brainstem Contributes to Neural Mechanisms of Hypertension. (2010)
  • Author(s): Matsukawa R, et al
  • Organizer: 第74回日本循環器学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2010-03-05
• [Presentation] Telmisartan Inhibits Sympathetic Nerve Activity through the Reduction of Oxidative Stress and Release of GABA in RVLM of Hypertensive Rats. (2010)
  • Author(s): Kishi T, et al
  • Organizer: 第74回日本循環器学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2010-03-05
• [Presentation] The Reduction of Brain Sigma-1 Receptor Contributes to Sympathetic Hyperactivation in Heart Failure. (2009)
  • Author(s): Ito K, Hirooka Y, Sunagawa K.
  • Organizer: Scientific Sessions 2009 of the American Heart Association.
  • Place of Presentation: Orland, U.S.A.
  • Year and Date: 2009-11-18
• [Presentation] Left Ventricular Hypertrophy Enhances the Expression of Mineralocorticoid Receptor and Epithelial Na Channels in the Brain and Leads to Salt-sensitive Sympathetic Hyperactivation and Left Ventricular Dysfunction. (2009)
  • Author(s): Ito K, Hirooka Y, Sunagawa K.
  • Organizer: Scientific Sessions 2009 of the American Heart Association.
  • Place of Presentation: Orland, U.S.A.
  • Year and Date: 2009-11-18
• [Presentation] The Reduction of Brain Sigma-1 Receptor Contributes to Sympathetic Hyperactivation in Heart Failure (2009)
  • Author(s): Ito K, et al
  • Organizer: Scientific Sessions of the American Heart Association
  • Place of Presentation: Orland
  • Year and Date: 2009-11-18
• [Presentation] Impact of Bionic Cardiology in Treating Refractory Cardiovascular Diseases. (2009)
  • Author(s): Sunagawa K.
  • Organizer: The 5^<th> China-Japan Cardiovascular Forum.
  • Place of Presentation: Beijind, Chaina
  • Year and Date: 2009-11-12
• [Presentation] Dysregulation of brain MR-ENaCs pathway contributes to the acquisition of brain Na sensitivity in mice with LVH (2009)
  • Author(s): 伊藤浩司, 他
  • Organizer: 第13回日本心不全学会
  • Place of Presentation: 福岡市
  • Year and Date: 2009-10-30
• [Presentation] エプレレノンは圧負荷モデルにおける脳内Na感受性亢進を抑制することによって食塩負荷に伴う交感神経活性化を軽減し心機能を改善する。-脳内MR-ENaC経路の重要性 (2009)
  • Author(s): 伊藤浩司, 他
  • Organizer: 第32回日本高血圧学会総会
  • Place of Presentation: 大津市
  • Year and Date: 2009-10-03
• [Presentation] Bionic autonomic neuromodulation revolutionizes cardiology in the 21st century. (2009)
  • Author(s): Sunagawa K.
  • Organizer: 31^<st> Annual International Conference of the IEEE Engineering in Medicine and Biokigy Society.
  • Place of Presentation: Mineapolis, U.S.A.
  • Year and Date: 2009-09-03
• [Presentation] Bionic autonomic neuromodulation revolutionizes cardiology in the 21st century. (2009)
  • Author(s): Sunagawa K
  • Organizer: EMBC 2009
  • Place of Presentation: Minneapolis
  • Year and Date: 2009-09-03
• [Presentation] Transneural Treatment in Patients with Arterial Pressure Dysregulation. (2009)
  • Author(s): Sunagawa K.
  • Organizer: 17^<th> Asian Pacific Congress of Cardiology.
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2009-05-21
• [Presentation] Equilibrium analysis between the venous return surface and cardiac output curve enables us to predict hemodynamic impact of percutaneous cardiopulmonary support. (2009)
  • Author(s): Tanaka A, Tsutsumi T, Sakamoto K, Hosokawa K, Murayama Y, Sunagawa K.
  • Organizer: Experimental Biology 2009.
  • Place of Presentation: New Orleans, U.S.A.
  • Year and Date: 2009-04-20
• [Presentation] Brain salt sensitivity in mice with LVH is enhanced via Rho-kinase pathway through ENaC activation. (2009)
  • Author(s): Ito K, Hirooka Y, Sunagawa K.
  • Organizer: Experimental Biology 2009.
  • Place of Presentation: New Orleans, U.S.A.
  • Year and Date: 2009-04-19
• [Presentation] Brain salt sensitivity in mice with LVH is enhanced via Rho-kinase pathway through ENaC activation (2009)
  • Author(s): Ito K, et al
  • Organizer: Experimental Biology 2009
  • Place of Presentation: New Orleans
  • Year and Date: 2009-04-19
• [Presentation] Cholinergic stimulation by donepezil as a novel antiatherotic treatment (2009)
  • Author(s): Inanaga K, et al
  • Organizer: 第73回日本循環器学会学術集会総会
  • Place of Presentation: 大阪
  • Year and Date: 2009-03-22
• [Presentation] Mitochondrial DNA, a Novel Therapeutic Target for Heart Failure (2009)
  • Author(s): Ide T, et al
  • Organizer: 第73回日本循環器学会学術集会総会
  • Place of Presentation: 大阪
  • Year and Date: 2009-03-22
• [Presentation] A novel anti-inflammatory effect of resveratrol through suppression of AngiotensinII-induced Hypertension and Interleukin-6 production (2009)
  • Author(s): Inanaga K, et al
  • Organizer: 第73回日本循環器学会学術集会総会
  • Place of Presentation: 大阪
  • Year and Date: 2009-03-22
• [Presentation] SIRT1, a Longevity Gene, Downregulates Angiotensin II Type 1 Receptor Expression. (2009)
  • Author(s): Miyazaki R, et al
  • Organizer: 第73回日本循環器学会学術集会総会
  • Place of Presentation: 大阪
  • Year and Date: 2009-03-22
• [Presentation] Chronic Kidney Disease (CKD)Deteriorates Left Ventricular(LV) Diastolic Function, Promotes Remodeling and Synergistically Worsens Survival after Myocardial Infarction(MI). (2009)
  • Author(s): Inoue T, et al
  • Organizer: 第73回日本循環器学会学術集会総会
  • Place of Presentation: 大阪
  • Year and Date: 2009-03-22
• [Presentation] Cholinergic Stimulation by Donepezil is a Novel Antiangiogenic approach. (2009)
  • Author(s): Miyazaki R, et al
  • Organizer: 第73回日本循環器学会学術集会総会
  • Place of Presentation: 大阪
  • Year and Date: 2009-03-21
• [Presentation] Short-term Vagal Nerve Stimulation protects myocardium from ischemia-reperfusion (I/R)injury (2009)
  • Author(s): Ando M, et al
  • Organizer: 第73回日本循環器学会学術集会総会
  • Place of Presentation: 大阪
  • Year and Date: 2009-03-21
• [Presentation] Prolyl hydroxylase inhibitors attenuated acute inflammatory responses hypoxia-inducible factor independent manner (2009)
  • Author(s): Takeda K, et al
  • Organizer: 第73回日本循環器学会学術集会総会
  • Place of Presentation: 大阪
  • Year and Date: 2009-03-21
• [Presentation] Ras/p38 MAPK/ERK-activated Caspase 3-dependent Apoptotic Pathway in Rostral Ventrolateral Medulla Increases Sympathetic Nerve Activity in Hypertensive Rats (2009)
  • Author(s): Kishi T, et al
  • Organizer: 第73回日本循環器学会学術集会総会
  • Place of Presentation: 大阪
  • Year and Date: 2009-03-21
• [Presentation] Intracerebroventricular-Infusion of Atorvastatin Reduces Sympathetic Nerve Activity by Inhibition of Rac1/NAD (P)H Oxidase and Upregulation ofMn-SOD in SHRSP (2009)
  • Author(s): Kishi T, et al
  • Organizer: 第73回日本循環器学会学術集会総会
  • Place of Presentation: 大阪
  • Year and Date: 2009-03-21
• [Presentation] MAPK/ERK Pathway Plays a Major Role in Redox Sensitive Signal Transduction in the RVLM of SHRSP. (2009)
  • Author(s): Koga Y, et al
  • Organizer: 第73回日本循環器学会学術集会総会
  • Place of Presentation: 大阪
  • Year and Date: 2009-03-21
• [Presentation] Atorvastatin Attenuates Telomere-dependent and Independent Neural Cell Senescence in the Cardiovascular Center of Brainstem in Stroke-prone Spontaneously Hypertensive Rats (2009)
  • Author(s): Kishi T, et al
  • Organizer: 第73回日本循環器学会学術集会総会
  • Place of Presentation: 大阪
  • Year and Date: 2009-03-20
• [Presentation] Enhanced brain Na sensitivity contributes to salt-inducedsympathetichyperactivation and deterioration of cardiac function in mice with LVH (2009)
  • Author(s): Ito K, et al
  • Organizer: 第73回日本循環器学会学術集会総会
  • Place of Presentation: 大阪
  • Year and Date: 2009-03-20
• [Presentation] Aldosterone and Salt Induces Hypertension Associated with Increased Oxidative Stress in the Brain of Apolipoprotein E Knockout Mice (2009)
  • Author(s): Araki S, et al
  • Organizer: 第73回日本循環器学会学術集会総会
  • Place of Presentation: 大阪
  • Year and Date: 2009-03-20
• [Presentation] Increased Oxidative Stress in Cardiovascular Center of Brain Stem Causes Sympatho-excitation in Dietary-induced Obesity Rat (2009)
  • Author(s): Konno S, et al
  • Organizer: 第73回日本循環器学会学術集会総会
  • Place of Presentation: 大阪
  • Year and Date: 2009-03-20
• [Presentation] Caspase 3-dependent Neural Cell Apoptosis and Telomere-dependent Senescence are Activated in the Cortex and Brainstem in Dietary-induced Obesity Rat (2009)
  • Author(s): Kishi T, et al
  • Organizer: 第73回日本循環器学会学術集会総会
  • Place of Presentation: 大阪
  • Year and Date: 2009-03-20
• [Presentation] Left Ventricular Hypertrophy Enhances the Expression of Mineralocorticoid Receptor and Epithelial Na Channels in the Brain and Leads to Salt-sensitive Sympathetic Hyperactivation and Left Ventricular Dysfunction. (2009)
  • Author(s): Ito K, et al
  • Organizer: Scientific Sessions of the American Heart Association
  • Place of Presentation: Orland
• [Presentation] Transcutaneous bionic baroreflex system is widely applicable for preventing severe orthostatic hypotension in patients with cervical cord injury. (2008)
  • Author(s): Yoshida M, Chishaki A, Murayama Y, Kimura S, Ando M, Saito T, Shiba K, Shiino T, Todaka K, Sunagawa K.
  • Organizer: Scientific Sessions 2008 of the American Heart Association.
  • Place of Presentation: New Orleans, U.S.A.
  • Year and Date: 2008-11-12
• [Presentation] Transcutaneous bionic baroreflex system is widely applicable for preventing severe orthostatic hypotension in patients with cervical cord injury (2008)
  • Author(s): Yoshida M, Chishaki A, Murayama Y, Kimura S, Ando M, Saito T, Shiba K, Shiino T, Todaka K, Sunagawa K.
  • Organizer: Scientific Sessions 2008 of the American Heart Association
  • Place of Presentation: Orland, U.S.A.
  • Year and Date: 2008-11-12
• [Presentation] Transcutaneous bionic baroreflex system is widely applicable for preventing severe orthostatic hypotension in patients with cervical cordinjury (2008)
  • Author(s): Yoshida M, et al
  • Organizer: Scientific Sessions 2008 of the American Heart Association
  • Place of Presentation: Orland, U.S.A.
  • Year and Date: 2008-11-12
• [Presentation] Telmisartan Manifests Powerful Anti-inflammatory Effects Beyond Class Effects of Angiotensin II Type 1 Blocker by Inhibiting Tumor Necrosis Factor alpha-Induced Interleukin 6 Expressions through Peroxisome Proliferator Activated Receptory Activation. (2008)
  • Author(s): Ichiki T, et al
  • Organizer: Scientific Sessions 2008 of the American Heart Association
  • Place of Presentation: Orland, U.S.A.
  • Year and Date: 2008-11-12
• [Presentation] Overexpression of Twinkle, a Mitochondria DNA Helicase, Ameliorates Cardiac Remodeling and Failure in Mice. (2008)
  • Author(s): Inoue T, et al
  • Organizer: Scientific Sessions 2008 of the American Heart Association
  • Place of Presentation: Orland, U.S.A.
  • Year and Date: 2008-11-10
• [Presentation] Ras/Raf/p38 MAPK/ERK pathway is activated in the rostral ventrolateral medulla of stroke-prone spontaneously hypertensive rats (2008)
  • Author(s): Kishi T, et al
  • Organizer: Scientific Sessions 2008 of the American Heart Association
  • Place of Presentation: Orland, U.S.A.
  • Year and Date: 2008-11-10
• [Presentation] High-salt intake superimposed on left ventricular hypertrophy activates brain ENaC and leads to sympathetic hyperactivation and ventricular dysfunction (2008)
  • Author(s): Ito K, et al
  • Organizer: Scientific Sessions 2008 of the American Heart Association
  • Place of Presentation: Orland, U.S.A.
  • Year and Date: 2008-11-10
• [Presentation] Overexpression Of Mitochondrial Transcription Factor A Protects Failing Myocardium From Oxidative Stress (2008)
  • Author(s): Yoshida M, et al
  • Organizer: Scientific Sessions 2008 of the American Heart Association
  • Place of Presentation: Orland, U.S.A.
  • Year and Date: 2008-11-10
• [Presentation] Intelligent neural regulation in managing cardiovascular diseases. (2008)
  • Author(s): Sunagawa K.
  • Organizer: 18th Meeting of the Cardiovascular System Dynamics Society.
  • Place of Presentation: Atlanta, U.S.A.
  • Year and Date: 2008-09-28
• [Presentation] Intelligent neural regulation in managing cardiovascular diseases (2008)
  • Author(s): Sunagawa K.
  • Organizer: 18th Meeting of the Cardiovascular System Dynamics Society
  • Place of Presentation: Atlanta, U.S.A.
  • Year and Date: 2008-09-28
• [Presentation] Intelligent neural regulation in managing cardiovascular diseases. (2008)
  • Author(s): Sunagawa K.
  • Organizer: XVIIIth Meeting of the Cardiovascular System Dynamics Society
  • Place of Presentation: Atlanta, U.S.A.
  • Year and Date: 2008-09-28
• [Presentation] Neural apoptosis in the vasomotor center of brainstem impairs baroreflex sensitivity in hypertensive rats. (2008)
  • Author(s): Kishi T, et al
  • Organizer: XVIIIth Meeting of the Cardiovascular System Dynamics Society
  • Place of Presentation: Atlanta, U.S.A.
  • Year and Date: 2008-09-28
• [Presentation] Noninvasive Transcutaneous Bionic Baroreflex System Prevents Severe Orthostatic Hypotension in Patients with Spinal Cord Injury. (2008)
  • Author(s): Yoshida M, Murayama Y, Chishaki A, Sunagawa K.
  • Organizer: 30^<th> Annual International Conference of the IEEE Engineering in Medicine and Biology Society.
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2008-08-22
• [Presentation] Noninvasive Transcutaneous Bionic Baroreflex System Prevents Severe Orthostatic Hypotension in Patients with Spinal Cord Injury (2008)
  • Author(s): Yoshida M, Murayama Y, Chishaki A, Sunagawa K.
  • Organizer: 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2008-08-22
• [Presentation] Noninvasive Transcutaneous Bionic Baroreflex System Prevents Severe Orthostatic Hypotension in Patients with Spinal Cord Injury (2008)
  • Author(s): Yoshida M, et al
  • Organizer: 30^<th> Annual International Conference of the IEEE Engineering in Medicine and Biology Society
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2008-08-22
• [Presentation] Sympatho-inhibitory effect of atorvastatin due to anti-senescence and attenuation of impaired neurogenesis in RVLM of SHRSP (2008)
  • Author(s): Kishi T, et al
  • Organizer: Experimental Biology 2008
  • Place of Presentation: San Diego, U.S.A.
  • Year and Date: 2008-04-09
• [Presentation] Azelnidipine inhibits the sympathetic nerve activity and improves baroreflex control of heart rate via anti-oxidant effect in the rostral ventrolateral medulla. (2008)
  • Author(s): Konno S, et al
  • Organizer: Experimental Biology 2008
  • Place of Presentation: San Diego, U.S.A.
  • Year and Date: 2008-04-08
• [Presentation] Rinin-angiotensin system and NAD(P)H oxidase activation in the rostral ventrolateral medulla are involved in the further blood pressure elevation on high sodium diet in spontaneously hypertensive rats. (2008)
  • Author(s): Koga Y, et al
  • Organizer: Experimental Biology 2008
  • Place of Presentation: San Diego, U.S.A.
  • Year and Date: 2008-04-07
• [Presentation] High salt intake deteriorates cardiac function of hypertrophied heart, possibly via excessive sympathetic drive. (2008)
  • Author(s): Ito K, et al
  • Organizer: Experimental Biology 2008
  • Place of Presentation: San Diego, U.S.A.
  • Year and Date: 2008-04-07
• [Presentation] Impaired neurogenesis and activated caspase 3-dependent apoptosis pathway in the rostral ventrolateral medulla causes hypertension instroke-prone spontaneously hypertensive rats (2008)
  • Author(s): Kishi T, et al
  • Organizer: Experimental Biology 2008
  • Place of Presentation: San Diego, U.S.A.
  • Year and Date: 2008-04-07
• [Presentation] Noninvasive Transcutaneous Bionic Baroreflex System Prevents Severe Orthostatic Hypotension in patients with Spinal Cord Injury. (2008)
  • Author(s): Yoshida M, Chishaki A, Saito T, Kimura S, Ando M, Tsutsumi T, Shiba K, Murayama Y, Sunagawa K.
  • Organizer: Experimental Biology 2008.
  • Place of Presentation: San Diego, U.S.A.
  • Year and Date: 2008-04-06
• [Presentation] Autonomic modulation by vagus nerve stimulation in heart failure. (2008)
  • Author(s): Sunagawa K.
  • Organizer: Experimental Biology 2008.
  • Place of Presentation: San Diego, U.S.A.
  • Year and Date: 2008-04-06
• [Presentation] Noninvasive Transcutaneous Bionic Baroreflex System Prevents Severe Orthostatic Hypotension in patients with Spinal Cord Injury (2008)
  • Author(s): Yoshida M, Chishaki A, Saito T, Kimura S, Ando M, Tsutsumi T, Shiba K, Murayama Y, Sunagawa K.
  • Organizer: Experimental Biology2008
  • Place of Presentation: San Diego, U.S.A.
  • Year and Date: 2008-04-06
• [Presentation] Autonomic modulation by vagus nerve stimulation in heart failure (2008)
  • Author(s): Sunagawa K.
  • Organizer: Experimental Biology 2008
  • Place of Presentation: San Diego, U.S.A.
  • Year and Date: 2008-04-06
• [Presentation] Olmesartan reduces oxidative stress in the brains of stroke-prone spontaneously hypertensive rats as measured by an in vivo ESR method. (2008)
  • Author(s): Araki S, et al
  • Organizer: Experimental Biology 2008
  • Place of Presentation: San Diego, U.S.A.
  • Year and Date: 2008-04-06
• [Presentation] Noninvasive Transcutaneous Bionic Baroreflex System Prevents Severe Orthostatic Hypotension in patients with Spinal Cord Injury. (2008)
  • Author(s): Yoshida M, et al
  • Organizer: Experimental Biology 2008
  • Place of Presentation: San Diego, U.S.A.
  • Year and Date: 2008-04-06
• [Presentation] Impaired neurogenesis in the rostral ventrolateral medulla causes hypertension in stroke-prone spontaneously hypertensive rats. (2007)
  • Author(s): Kishi T, Hirooka Y, Sunagawa K.
  • Organizer: Heart Association.
  • Place of Presentation: Orland, U.S.A.
  • Year and Date: 2007-11-07
• [Presentation] High salt diet exacerbates hypertension via increased oxidative stress in the rostral ventrolateral medulla and sympathetic hyperactivity in spontaneously hypertensive rats. (2007)
  • Author(s): Koga Y, Hirooka Y, Araki S, Nozoe M, Kishi T, Sunagawa K.
  • Organizer: Heart Association.
  • Place of Presentation: Orland, U.S.A.
  • Year and Date: 2007-11-07
• [Presentation] Modulation of the myocardial redox state by vagal nerve stimulation after experimental myocardial infarction. (2007)
  • Author(s): Tsutsumi T, Ide T, Yamato M, Kudou W, Andou M, Hirooka Y, Utsumi H, Tsutsui H, Sunagawa K.
  • Organizer: Heart Association.
  • Place of Presentation: Orland, U.S.A.
  • Year and Date: 2007-11-07
• [Presentation] Vagal Stimulation Suppresses Reactive Oxygen Species (ROS)in the Failing Myocardium in Mice (2007)
  • Author(s): Tsutsumi T, et. al.
  • Organizer: American Heart Association Scientific Session 2007
  • Place of Presentation: Orland(U.S.A.)
  • Year and Date: 2007-11-07
• [Presentation] High Salt Diet Exacerbates Hypertension via Increased Oxidative Stress in the Rostral Ventrolateral Medulla and Sympathetic Hyperactivity in Spontaneously Hypertensive Rats (2007)
  • Author(s): Koga Y, et. al.
  • Organizer: American Heart Association Scientific Session 2007
  • Place of Presentation: Orland(U.S.A.)
  • Year and Date: 2007-11-07
• [Presentation] Noninvasive Transcutaneous Bionic Baroreflex System (2007)
  • Author(s): Yoshida M, et. al.
  • Organizer: American Heart Association Scientific Session 2007
  • Place of Presentation: Orland(U.S.A.)
  • Year and Date: 2007-11-07
• [Presentation] Impaired Neurogenesis in the Rostral Ventrolateral Medulla Cause Hypertension in Stroke-prone Spontaneously Hypertensive Rats (2007)
  • Author(s): Kishi T, et. al.
  • Organizer: AmericanHeart AssociationScientificSession2007
  • Place of Presentation: Orland(U.S.A.)
  • Year and Date: 2007-11-07
• [Remarks] ホームページ等
  • URL: http://www.med.kyushu-u.ac.jp/cardiol/kyoshitsu/baio/index.html
• [Remarks]
  • URL: http://www.med.kyushu-u.ac.jp/cardiol/kyoshitsu/baio/index.html
• [Patent(Industrial Property Rights)] Bionic baroreflex system to treat heart failure with preserved ejection fraction (2010)
  • Inventor(s): Sunagawa K, et al
  • Industrial Property Rights Holder: 九州大学
  • Filing Date: 2010-09-21
  • Overseas
• [Patent(Industrial Property Rights)] Cardiovascular disease therapy device (2009)
  • Inventor(s): 砂川賢二
  • Industrial Property Rights Holder: 九州大学
  • Filing Date: 2009-03-19
  • Overseas
• [Patent(Industrial Property Rights)] Cardiovascular disease therapy device (2009)
  • Inventor(s): Sunagawa K, et al
  • Industrial Property Rights Holder: 九州大学
  • Filing Date: 2009-03-19
  • Overseas
• [Patent(Industrial Property Rights)] 経皮的電気刺激による血圧安定化システム (2008)
  • Inventor(s): 砂川賢二
  • Industrial Property Rights Holder: 九州大学
  • Filing Date: 2008-10-15
• [Patent(Industrial Property Rights)] 経皮的電気刺激による血圧安定化システム (2008)
  • Inventor(s): 砂川賢二
  • Industrial Property Rights Holder: 九州大学
  • Filing Date: 2008-10-15
• [Patent(Industrial Property Rights)] 経皮的電気刺激による血圧安定化システム (2008)
  • Inventor(s): 砂川賢二
  • Industrial Property Rights Holder: 九州大学
  • Filing Date: 2008-10-15
• [Patent(Industrial Property Rights)] 経皮的電気刺激による血圧安定化システム (2008)
  • Inventor(s): 砂川賢二
  • Industrial Property Rights Holder: 九州大学
  • Filing Date: 2008-10-15
  • Overseas
• [Patent(Industrial Property Rights)] 経皮的電気刺激による血圧安定化システム (2008)
  • Inventor(s): 砂川賢二
  • Industrial Property Rights Holder: 九州大学
  • Filing Date: 2008-10-15
• [Patent(Industrial Property Rights)] 経皮的電気刺激による血圧安定化システム (2008)
  • Inventor(s): 砂川賢二, 他
  • Industrial Property Rights Holder: 九州大学
  • Filing Date: 2008-10-15
  • Overseas
• [Patent(Industrial Property Rights)] 経皮的電気刺激による血圧安定化システム (2008)
  • Inventor(s): 砂川賢二, 他
  • Industrial Property Rights Holder: 九州大学
  • Filing Date: 2008-10-15
• [Patent(Industrial Property Rights)] 経皮的電気刺激による血圧定化システム (2007)
  • Inventor(s): 砂川 賢二
  • Industrial Property Rights Holder: 砂川 賢二
  • Filing Date: 2007-10-15
  • Overseas