Identification of new DNA damages by DNA adductome analysis

• Project/Area Number: 18101003
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Risk sciences of radiation/Chemicals
• Research Institution: Kyoto University
• Principal Investigator: MATSUDA Tomonari Kyoto University, 大学院・工学研究科, 准教授 (50273488)
• Co-Investigator(Kenkyū-buntansha): SAEKI Kenichi 横浜薬科大学, 薬学部, 准教授 (60254306) ; TAKAMURA Takeji 神奈川工科大学, 応用化学科, 准教授 (50342910) ; KAWANISHI Masanobu 大阪府立大学, 産学官連携機構, 助教 (70332963)
• Project Period (FY): 2006 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥97,240,000 (Direct Cost: ¥74,800,000、Indirect Cost: ¥22,440,000); Fiscal Year 2010: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000); Fiscal Year 2009: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000); Fiscal Year 2008: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000); Fiscal Year 2007: ¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000); Fiscal Year 2006: ¥44,460,000 (Direct Cost: ¥34,200,000、Indirect Cost: ¥10,260,000)
• Keywords: DNAアダクトーム / DNA付加体 / 突然変異 / LC / MS / DNA損傷 / LC/MS/MS / アダクトーム / 過酸化脂質 / 3-ニトロベンゾアントロン / DNA アダクト-ム / DNA 付加体

Research Abstract

DNA, a principal genetic material, is damaged by attacking from various environmental factors. We developed a method named "DNA adductome" to detect DNA adducts comprehensively, and found that major DNA adducts in human organ are formed from lipid-oxidation. Additionally, we developed the method to quantify DNA adducts caused by alcohol drinking, acrylamide, nano-particles, air-pollutants, to clarify their health risk.

Research Products

• [Journal Article] Genotoxicity of colloidal fullerene c(60) (2011)
  • Author(s): Matsuda, S., Matsui, S., Shimizu, Y., Matsuda, T.
  • Journal Title: Environ Sci Technol 45 Pages: 4133-4138
  • Peer Reviewed
• [Journal Article] Acrylamide genotoxicity in young versus adult gpt delta male rats (2011)
  • Author(s): Koyama, N., Matsuda, T., Honma, M., et al.
  • Journal Title: Mutagenesis. in press
  • Peer Reviewed
• [Journal Article] Application of the DNA adductome approach to assess the DNA-damaging capability of in vitro micronucleus test-positive compounds (2011)
  • Author(s): Kato, K., Kawanishi, M., Yagi, T., Matsuda T., et al
  • Journal Title: Mutat Res 721 Pages: 21-26
  • Peer Reviewed
• [Journal Article] Application of the DNA adductome approach to assess the DNA-damaging capability of in vitro micronucleus test-positive compounds (2011)
  • Author(s): Kato, K., Matsuda, T., et. al.
  • Journal Title: Mutat.Res Volume: 721 Pages: 21-26
  • Peer Reviewed
• [Journal Article] Genotoxicity of acrylamide in vitro : Acrylamide is not metabolically activated in standard in vitro systems (2011)
  • Author(s): Koyama, N., Matsuda, T., et. al.
  • Journal Title: Environ Mol Mutagen Volume: 52 Pages: 11-19
  • Peer Reviewed
• [Journal Article] Effects of acetaldehyde inhalation in mitochondrial aldehyde dehydrogenase deficient mice (Aldh2-/-) (2010)
  • Author(s): Oyama, T., Nagayoshi, H., Matsuda, T., Kawamoto, T., et al.
  • Journal Title: Front Biosci (Elite Ed) 2 Pages: 1344-1354
  • Peer Reviewed
• [Journal Article] Anticipated Mutation Assay Using Single-molecule Real-time (SMRT TM) Sequencing Technology (2010)
  • Author(s): Matsuda, T.
  • Journal Title: Genes and Environment 32 Pages: 21-24
  • Peer Reviewed
• [Journal Article] DNA modifications by the omega-3 lipid peroxidation-derived mutagen 4-oxo-2-hexenal in vitro and their analysis in mouse and human DNA (2010)
  • Author(s): Kawai, K., Chou, P.H., Matsuda, T., Kasai, H., et al.
  • Journal Title: Chem Res Toxicol 23 Pages: 630-636
  • Peer Reviewed
• [Journal Article] Detection of lipid peroxidation-induced DNA adducts caused by 4-oxo-2(E)-nonenal and 4-oxo-2(E)-hexenal in human autopsy tissues (2010)
  • Author(s): Chou, P.H., Matsuda, T., et al.
  • Journal Title: Chem Res Toxicol 23 Pages: 1442-1448
  • Peer Reviewed
• [Journal Article] Detection of lipid peroxidation-induced DNA adducts caused by 4-oxo-2(E)-nonenal and 4-oxo-2(E)-hexenal in human autopsy tissues (2010)
  • Author(s): Chou, P.H., Mtsuda, T., et. al.
  • Journal Title: Chem Res Toxicol Volume: 23 Pages: 1442-1448
  • Peer Reviewed
• [Journal Article] Genotoxicity of acrylamide in vitro : Acrylamide is not metabolically activated in standard in vitro systems. (2010)
  • Author(s): Koyama N, Yasui M, Matsuda T, Honma M, et al.
  • Journal Title: Environ Mol Mutagen (in press)
  • Peer Reviewed
• [Journal Article] DNA modifications by the omega-3 lipid peroxidation-derived mutagen 4-oxo-2-hexenal in vitro and their (2010)
  • Author(s): Kawai K, Chou PH, Matsuda T, Kasai H, et al.
  • Journal Title: Chem Res Toxicol 23 Pages: 630-636
  • Peer Reviewed
• [Journal Article] Lipid peroxidation generates a body odor component trans-2-nonenal covalently bound to protein in vivo. (2010)
  • Author(s): Ishino K, Wakita C, Matsuda T, Uchida K, et al.
  • Journal Title: J Biol Chem (in press)
  • Peer Reviewed
• [Journal Article] N2-ethylidene-2'-deoxyguanosine DNA adducts in organs of Aldh2 Knockout mice treated with acetaldehyde inhalation. (2010)
  • Author(s): Oyama, T., Nagayoshi, H., Matsuda, T., Oka, M., Isse, T., Yu, H.S., Phuong, P.T.T., Tanaka, M., Kagawa, N., Kaneko, K., Kawamoto, T
  • Journal Title: Frontiers in Bioscience (in press)
  • Peer Reviewed
• [Journal Article] Genotoxicity of nanoparticles in in vitro micronuclei, in vivo comet and mutation assay systems. (2010)
  • Author(s): Yukari Totsuka, Takashi Higuchi, Toshio Imai, Akiyoshi Nishikawa, Takehiko Nohmi, Tatsuya Kato, Shuich Masuda, Naohide Kinae, Kyoko Hiyoshi, Sayaka Ogo, Masanobu Kawanishi, Takashi Yagi, Takamichi Ichinose, Takashi Sugimura, Keiji Wakabayashi.
  • Journal Title: Particle and fibre toxicology (in pree)
  • Peer Reviewed
• [Journal Article] Establishment of yeast reporter assay systems to detect ligands of thyroid hormone receptors alpha and beta. (2010)
  • Author(s): Kazuhiro Shiizaki, Shota Asai, Shingo Ebata, Masanobu Kawanishi, Takashi Yagi.
  • Journal Title: Toxicology in Vitro (in pree)
  • Peer Reviewed
• [Journal Article] Radiation Dose-Rate Effect on Mutation Induction in Spleen and Liver of gpt delta Mice (2010)
  • Author(s): Naohito Okudaira, Yoshihiko Uehara, Kazuo Fujikawa, Nao Kagawa, Akira Ootsuyama, Toshiyuki Norimura, Ken-ichi Saeki, Takehito Nohmi, Ken-ichi masumura, Tsuneya Matsumoto, Yoichi Oghiso, Kimio Tanaka, Kazuaki Ichinohe, Shingo Nakamura, Satoshi Tanaka, Tesuya Ono
  • Journal Title: Radiation Res 173 Pages: 138-147
  • Peer Reviewed
• [Journal Article] Genotoxicity of nano/microparticles in in vitro micronuclei, in vivo comet and mutation assay systems (2009)
  • Author(s): Totsuka, Y., Kawanishi, M., Wakabayashi, K., et al.
  • Journal Title: Part Fibre Toxicol 6 Pages: 23-23
  • Peer Reviewed
• [Journal Article] The genotoxic air pollutant 3-nitrobenzanthrone and its reactive metabolite N-hydroxy-3-aminobenzanthrone lack initiating and complete carcinogenic activity in NMRI mouse skin (2009)
  • Author(s): Schmeiser, H.H., Takamura-Enya, T., Arlt, V.M., et al
  • Journal Title: Cancer Lett 284 Pages: 21-29
  • Peer Reviewed
• [Journal Article] Increased formation of gastric N(2)-ethylidene-2'-deoxyguanosine DNA adducts in aldehyde dehydrogenase-2 knockout mice treated with ethanol (2009)
  • Author(s): Nagayoshi, H., Matsuda, T., et al
  • Journal Title: Mutat Res 673 Pages: 74-77
  • Peer Reviewed
• [Journal Article] Genotoxicity of 3, 6-dinitrobenzo[e]pyrene, a novel mutagen in ambient air and surface soil, in mammalian cells in vitro and in vivo (2009)
  • Author(s): Kawanishi, M., Yagi, T., et al
  • Journal Title: Mutagenesis 24 Pages: 279-284
  • Peer Reviewed
• [Journal Article] Quantification of 3-nitrobenzanthrone-DNA adducts using online column-switching HPLC-electrospray tandem mass spectrometry (2009)
  • Author(s): Gamboa da Costa, G., Takamura-Enya, T., Phillips, D.H., et al.
  • Journal Title: Chem Res Toxicol 22 Pages: 1860-1868
  • Peer Reviewed
• [Journal Article] 液体クロマトグラフィータンデム質量分析法を用いたDNA損傷研究法. (2009)
  • Author(s): 松田, 永吉, 椙村, 周
  • Journal Title: J.Mass Spectrom.Soc.Jpn. 57 Pages: 301-304
  • NAID: 10025571762
• [Journal Article] アダクトミクス-DNAおよびタンパク質付加体の網羅的解析. (2009)
  • Author(s): 松田, 足立, 周
  • Journal Title: 実験医学増刊 27 Pages: 2481-2488
• [Journal Article] Quantification of 3-nitrobenzanthrone-DNA adducts using online column-switching HPLC-electrospray tandem mass spectrometry. (2009)
  • Author(s): Gamboa da Costa G, Singh R, Arlt VM, Mirza A, Richards M, Takamura-Enya T, Schmeiser HH, Farmer PB, Phillips DH
  • Journal Title: Chem Res Toxicol 22(11) Pages: 1860-1868
  • Peer Reviewed
• [Journal Article] Isolation and identification of a novel aromatic amine mutagen produced by the Maillard reaction (2009)
  • Author(s): Nishigaki R, Watanabe T, Kajimoto T, Tada A, Takamura-Enya T, Enomoto S, Nukaya H, Terao Y, Muroyama A, Ozeki M, Node M, Hasei T, Totsuka Y, Wakabayashi K
  • Journal Title: Chem Res Toxicol 22(9) Pages: 1588-1593
  • Peer Reviewed
• [Journal Article] H. Translesional DNA synthesis through a C8-guanyl adduct of 2-amino-1-methyl-6-phenylimidazo[4, 5-b]pyridine(PhIP)in Vitro : REV1 inserts dC oppostie the lesion, and DNA polymerase kappa potentially catalyzes extension reaction from the 3'-dC terminus. (2009)
  • Author(s): Fukuda H, Takamura-Enya T, Masuda Y, Nohmi T, Seki C, Kamiya K, Sugimura T, Masutani C, Hanaoka F, Nakagama H.
  • Journal Title: J Biol Chem 248(38) Pages: 25585-25592
  • Peer Reviewed
• [Journal Article] The genotoxic air pollutant 3-nitrobenzanthrone and its reactive metabolite N-hydroxy-3-aminobenzanthrone lack initiating and complete carcinogenic activity in NMRI mouse skin. (2009)
  • Author(s): Scheiser HH, Furstenberger G, Takamura-Enya T, Phillips DH, Arlt VM.
  • Journal Title: Cancer Lett 284(1) Pages: 21-29
  • Peer Reviewed
• [Journal Article] Genotoxicity of 3, 6-dintrobenzo[e]pyrene, a novel mutagen in ambient air and surface soil, in mammalian cells in vitro and in vivo. (2009)
  • Author(s): Masanobu Kawanishi, Tetsushi Watanabe, Soichiro Hagio, Sayaka Ogo, Chiaki Shimohara, Rika Jouchi, Saori Takayama, Tomohiro Hasei, Teruhisa Hirayama, Yoshimitsu Oda, Takashi Yagi
  • Journal Title: Mutagenesis 24(3) Pages: 279-284
  • Peer Reviewed
• [Journal Article] Differential responese of various pharmaceuticals to human estrogen receptors alpha and beta in newly-constructed yeast reporter assays. (2009)
  • Author(s): Wai-Ling Chu, Kazuhiro Shiizaki, Masanobu Kawanishi, Takashi Yagi.
  • Journal Title: Genes and Environment 31(3) Pages: 80-86
  • Peer Reviewed
• [Journal Article] ヒト細胞におけるアミノビフェニルDNA付加体の損傷乗り越えDNA合成を介した突然変異誘発 (2009)
  • Author(s): 澤井知子, 川西優喜, 八木孝司, 高村岳樹
  • Journal Title: 放射線生物研究 44(3) Pages: 274-284
  • NAID: 40016838872
• [Journal Article] Increased formation of gastric N(2)-ethylidene-2'-deoxyguanosine DNA adducts in aldehyde dehydrogenase-2 knockout mice treated with ethanol. (2009)
  • Author(s): Nagayoshi, H., Matsuda, T., et al.
  • Journal Title: Mutation Research 673 Pages: 74-77
  • Peer Reviewed
• [Journal Article] Mutagenic specificity of N-nitrosotaurocholic acid in supF shuttle vector plasmids. (2009)
  • Author(s): Kawanishi, M., Nishida, H., Totsuka, Y., Nishiraura, K., Wakabayashi, K., Yagi, T.
  • Journal Title: Genes and Environment 31 Pages: 9-14
  • NAID: 110007138018
  • Peer Reviewed
• [Journal Article] Establishment of a method for analyzing translesion DNA synthesis across a single bulky adduct in human cells. (2009)
  • Author(s): Sawai, T., Kawanishi, M., Takamura-Enya, T., Yagi, T.
  • Journal Title: Genes and Environment 31 Pages: 24-30
  • NAID: 110007138016
  • Peer Reviewed
• [Journal Article] Genotoxicity of 3, 6-dinitrobenzo[e]pyrene, a novel mutagen in ambient air and surface soil, in mammalian cells in vitro and in vivo. (2009)
  • Author(s): Kawanishi, M. ., Watanabe, T., Hagio, S., Ogo, S., Shiraohara, C., Jouchi, R., Takayama, S., Hasei, T., Hirayama, T., Oda, Y., Yagi, T.
  • Journal Title: Mutagenesis (in press)
  • Peer Reviewed
• [Journal Article] Mutagenic specificity of N-acetoxy-3-aminobenzanthrone, a major metabolically activated form of 3-nitrobenzanthrone, in shuttle vector plasmids propagated in human cells (2008)
  • Author(s): Nishida, H., Kawanishi, M., Takamura-Enya, T., Yagi, T.
  • Journal Title: Mutat Res 654 Pages: 82-87
  • Peer Reviewed
• [Journal Article] Oxidative DNA damage in XPC-knockout and its wild mice treated with equine estrogen (2008)
  • Author(s): Okamoto Y., Chou P., Kim S., Suzuki N., Laxmi Y., Okamoto K., Liu X., Matsuda T. and Shibutani S.
  • Journal Title: Chem Res Toxicol 21 Pages: 1120-1124
  • Peer Reviewed
• [Journal Article] Mutagenic specificity of N-acetoxy-3-aminobenzanthrone a major metabolically activated form of 3-nitrobenzanthrone, in shuttle vector plasmids propagated in human cells (2008)
  • Author(s): Nishida H., Kawanishi M.., Takamura-Enya T. and Yagi T.
  • Journal Title: Mutat Res 654 Pages: 82-87
  • Peer Reviewed
• [Journal Article] Oxidative DNA damage in XPC-knockout and its wild mice treated with equine estrogen. (2008)
  • Author(s): Okamoto, Y., Chou, P., Kim, S., Suzuki, N., Laxmi, Y., Okaraoto, K., Liu, X., Matsuda, T., Shibutani, S.
  • Journal Title: Chem Res Toxicol 21 Pages: 1120-1124
  • Peer Reviewed
• [Journal Article] Aryl hydrocarbon receptor and estrogen receptor ligand activity of organic extracts from road dust and diesel exhaust particulates. (2008)
  • Author(s): Misaki, K., Suzuki, M., Nakamura, M., Handa, H., Iida, M., Kato, T., Matsui, S., Matsuda, T.
  • Journal Title: Arch Environ Contam Toxicol 55 Pages: 199-209
  • Peer Reviewed
• [Journal Article] Mutagenic specificity of N-acetoxy-3-aminobenzanthrone, a major metabolically activated form of 3-nitrobenzanthrone, in shuttle vector plasmids propagated in human cells. (2008)
  • Author(s): Nishida, H., Kawanishi, M. ., Takamura-Enya, T. ., Yagi, T.
  • Journal Title: Mutat Res 654 Pages: 82-87
  • Peer Reviewed
• [Journal Article] Omeprazole alleviates benzo[a]pyrene cytotoxicity by inhibition of CYPlAl activity in human and mouse hepatoma cells. (2008)
  • Author(s): Shiizaki, K., Ohsako, S., Kawanishi, M. ., Yagi, T.
  • Journal Title: Basic Clin Pharmacol Toxicol 103 Pages: 468-475
  • Peer Reviewed
• [Journal Article] Detection of enaogenous DNA aaaucts, O-carooxymetnyl-2-deoxyguanosine and 3-ethanesulfonic acid-2'-deoxycytidine, in the rat stomach after duodenal reflux. (2008)
  • Author(s): Terasaki, M., Totsuka, Y., Nishimura, K., Mukaisho, K., Chen, K., Hattori, T., Takamura-Enya, T. ., Sugimura, T., Wakabayashi, K.
  • Journal Title: Cancer Sci 99 Pages: 1741-1746
  • Peer Reviewed
• [Journal Article] Evaluation of the mutagenicity of nitration products derived from phenalenone (1H-phenalen-1-one). (2008)
  • Author(s): Misaki, K., Hisamatsu, Y., Suzuki, H., Takamura-Enya, T. .
  • Journal Title: Mutagenesis 23 Pages: 359-366
  • Peer Reviewed
• [Journal Article] Structural identification of DNA adducts derived from 3-nitrobenzanthrone, a potent carcinogen present in the atmosphere (2007)
  • Author(s): Takamura-Enya, T., Kawanishi, M., Yagi, T., Hisamatsu, Y.
  • Journal Title: Chem Asian J 2 Pages: 1174-1185
  • Peer Reviewed
• [Journal Article] DNA adduct formation and oxidative stress from the carcinogenic urban air pollutant 3-nitrobenzanthrone and its isomer 2-nitrobenzanthrone, in vitro and in vivo (2007)
  • Author(s): Nagy, E., Adachi, S., Takamura-Enya,T., Zeisig, M., Moller, L.
  • Journal Title: Mutagenesis 22 Pages: 135-145
  • Peer Reviewed
• [Journal Article] Increased formation of hepatic N2-ethylidene-2'-deoxyguanosine DNA adducts in aldehyde dehydrogenase 2-knockout mice treated with ethanol (2007)
  • Author(s): Matsuda, T., et al
  • Journal Title: Carcinogenesis 28 Pages: 2363-2366
  • Peer Reviewed
• [Journal Article] DNA adduct formation in human hepatoma cells treated with 3-nitrobenzanthrone : analysis by the (32)P-postlabeling method (2007)
  • Author(s): Kanno, T., Kawanishi, M., Takamura-Enya, T., Arlt, V.M., Phillips, D.H., Yagi, T.
  • Journal Title: Mutat Res 634 Pages: 184-191
  • Peer Reviewed
• [Journal Article] Application of the adductome approach to assess intertissue DNA damage variations in human lung and esophagus (2007)
  • Author(s): Kanaly, R.A., Matsui, S., Hanaoka, T., Matsuda, T.
  • Journal Title: Mutation Research 625 Pages: 83-93
  • Peer Reviewed
• [Journal Article] Mutagenicity and DNA adduct formation by the urban air pollutant 2-nitrobenzanthrone (2007)
  • Author(s): Arlt, V.M., Glatt, H., Gamboa da Costa, G., Reynisson, J., Takamura-Enya, T., Phillips, D.H.
  • Journal Title: Toxicol Sci 98 Pages: 445-457
  • Peer Reviewed
• [Journal Article] Application of the adductome approach to assess intertissue DNA damage variations in human lung and esophagus (2007)
  • Author(s): Kanaly R., Matsui S., Hanaoka T. and Matsuda T.
  • Journal Title: Mutat Res 625 Pages: 83-93
  • Peer Reviewed
• [Journal Article] Increased formation of hepatic N2-ethylidene-2'-deoxyguanosine DNA adducts in aldehyde dehydrogenase 2-knockout mice treated with ethanol (2007)
  • Author(s): Matsuda T.., Matsumoto A., Uchida M., Kanaly R., Misaki K., Shibutani S., Kawamoto T., Kitagawa K., Nakayama K., Tomokuni K. and Ichiba M.
  • Journal Title: Carcinogenesis 28 Pages: 2363-2366
  • Peer Reviewed
• [Journal Article] Molecular evidence of the involvement of the nucleotide excision repair (NER) system in the repair of the mono(ADP-ribosyl)ated DNA adduct produced by pierisin-1, an apoptosis-inducing protein from the cabbage butterfly (2007)
  • Author(s): Kawanishi M.., Matsukawa K., Kuraoka I., Takamura-Enya T.., Totsuka Y., Matsumoto Y., Watanabe M., Zou Y., Tanaka K., Sugimura T., Wakabayashi K. and Yagi T
  • Journal Title: Chem Res Toxicol 20 Pages: 694-700
  • Peer Reviewed
• [Journal Article] Application of the adductome approach to assess intertissue DNA damage variations in human lung and esophagus (2007)
  • Author(s): Kanaly RA, Matsui S, Hanaoka T, Matsuda T
  • Journal Title: Mutation Research 625 Pages: 83-93
  • Peer Reviewed
• [Journal Article] Aryl hydrocarbon receptor ligand activity of polycyclic aromatic ketones and polycyclic aromatic quinones (2007)
  • Author(s): Misaki K, Matsuda T, et. al.
  • Journal Title: Environmental Toxicology and Chemistry 26 Pages: 1370-1379
  • Peer Reviewed
• [Journal Article] Increased formation of hepatic N2-ethylidene-2'-deoxyguanosine DNA adducts in aldehyde dehydrogenase 2 knockout mice treated with ethanol (2007)
  • Author(s): Matsuda T, et. al.
  • Journal Title: Carcinogenesis 28 Pages: 2363-2366
  • Peer Reviewed
• [Journal Article] DNA adduct formation and oxidative stress from the carcinogenic urban air pollutant 3- nitrobenzanthrone and its isomer 2-nitrobenzanthrone, in vitro and in vivo (2007)
  • Author(s): Takamura-Enya T, et. al.
  • Journal Title: Mutagenesis 22(2) Pages: 135-45
  • Peer Reviewed
• [Journal Article] Molecular Evidence of Involvement of Nucleotide Excision Repair (NER) System in Repair of the Mono ADP-ribosylated DNA Adduct Produced by Pierisin-1, an Apoptosis-inducing protein from Cabbage Butterfly (2007)
  • Author(s): Kawanishi M, Takamura-Enya T, et. al.
  • Journal Title: Chemical Research in Toxicology 20(4) Pages: 694-700
  • Peer Reviewed
• [Journal Article] DNA adduct formation in human hepatoma cells treated with 3-nitrobenzanthrone: analysis by the 32P-postlabeling method (2007)
  • Author(s): Kawanishi M, Takamura-Enya T, et. al.
  • Journal Title: Mutation Research 634(1-2) Pages: 184-191
  • Peer Reviewed
• [Journal Article] Structural Identification of DNA Adducts Derived from 3-Nitrobenzanthrone, a Potent Carcinogen Present in the Atmosphere (2007)
  • Author(s): Takamura-Enya T, Kawanishi M, et. al.
  • Journal Title: Chemistry An Asian Journal 2(9) Pages: 1174-1185
  • Peer Reviewed
• [Journal Article] Modification of mutagenicity by fluorine-substitution on diazachrysene (2007)
  • Author(s): Saeki K, et. al.
  • Journal Title: J. Health Sci. 53 Pages: 320-324
  • NAID: 110006278747
  • Peer Reviewed
• [Journal Article] Clastogenicity of quinoline and monofluorinated quinolines in Chinese hamster lung cells (2007)
  • Author(s): Saeki K, et. al.
  • Journal Title: J. Health Sci. 53 Pages: 325-328
  • NAID: 110006278748
  • Peer Reviewed
• [Journal Article] Clastogenicity of quinoline derivatives in the liver micronucleus assay using rats and mice (2007)
  • Author(s): Saeki K, et. al.
  • Journal Title: J. Health Sci 53 Pages: 470-474
  • NAID: 110006366929
  • Peer Reviewed
• [Journal Article] Mutagenicity and DNA adduct formation by the urban air pollutant 2-nitrobenzanthrone (2007)
  • Author(s): Takamura-Enya T, et. al.:
  • Journal Title: Toxicol Sci 98(2) Pages: 445-57
  • Peer Reviewed
• [Journal Article] DNA adduct formation and oxidative stress from the carcinogenic urban air pollutant 3-nitrobenzanthrone and its isomer 2-nitrobenzanthrone, in vitro and in vivo (2007)
  • Author(s): Takamura-Enya T, et. al.
  • Journal Title: Mutagenesis 22(2) Pages: 135-45
  • Peer Reviewed
• [Journal Article] Increased formation of hepatic N2-ethylidene-2'-deoxyguanosine DNA adducts in aldehyde dehydrogenase 2 knockout mice treated with ethanol (2007)
  • Author(s): T.Matsuda et al.
  • Journal Title: Carcinogenesis (in press)
• [Journal Article] Metabolic Enzyme Induction by HepG2 Cells Exposed to Oxygenated and Non-oxygenated Polycyclic Aromatic Hydrocarbons (2007)
  • Author(s): Misaki, K, Matsui, S, Matsuda, T
  • Journal Title: Chemical Research in Toxicology 20 Pages: 277-283
• [Journal Article] DNA adduct formation and oxidative stress from the carcinogenic urban air pollutant 3-nitrobenzanthrone and its isomer 2-nitrobenzanthrone, in vitro and in vivo (2007)
  • Author(s): Nagy, E et al.
  • Journal Title: Mutagenesis 22 Pages: 135-145
• [Journal Article] Molecular Evidence of Involvement of Nucleotide Excision Repair (NER) System in Repair of the Mono ADP-ribosylated DNA Adduct Produced by Pierisin-1, an Apoptosis-inducing Protein from Cabbage Butterfly (2007)
  • Author(s): M.Kawanishi et al.
  • Journal Title: Chemical Research in Toxicology (in press)
• [Journal Article] Mutagenic activities and physicochemical properties of selected nitrobenzanthrones (2006)
  • Author(s): Takamura-Enya, T., Suzuki, H., Hisamatsu, Y.
  • Journal Title: Mutagenesis 21 Pages: 399-404
  • Peer Reviewed
• [Journal Article] DNA damage and acute toxicity caused by the urban air pollutant 3-nitrobenzanthrone in rats : characterization of DNA adducts in eight different tissues and organs with synthesized standards (2006)
  • Author(s): Nagy, E., Adachi, S., Takamura-Enya T., Zeisig, M., Moller, L.
  • Journal Title: Environ Mol Mutagen 47 Pages: 541-552
  • Peer Reviewed
• [Journal Article] Increased DNA-damage-in ALDH2-deficient alcoholics (2006)
  • Author(s): Matsuda, T., Yabushita, H., Kanaly, R.A., Shibutani, S., Yokoyama, A.
  • Journal Title: Chem Res Toxicol 19 Pages: 1374-1378
  • Peer Reviewed
• [Journal Article] Increased DNA damage in ALDH2-deficient alcoholics (2006)
  • Author(s): Matsuda T.., Yabushita H., Kanaly R., Shibutani S. and Yokoyama A
  • Journal Title: Chem Res Toxicol 19 Pages: 1374-1378
  • Peer Reviewed
• [Journal Article] Increased DNA Damage in ALDH2-Deficient Alcoholics (2006)
  • Author(s): T.Matsuda et al.
  • Journal Title: Chemical Research in Toxicology 19 Pages: 1374-1378
• [Journal Article] Antiestrogens and the Formation of DNA Damage in Rats : A Comparison (2006)
  • Author(s): Kim, S et al.
  • Journal Title: Chemical Research in Toxicology 19 Pages: 852-858
• [Journal Article] Development of the adductome approach to detect DNA damage in humans (2006)
  • Author(s): R.A.Kanaly et al.
  • Journal Title: Antioxid. Redox Signal 8 Pages: 993-1001
• [Journal Article] Palladium-catalyzed direct N-arylation of nucleosides, nucleotides, and oligonucleotides for efficient preparation of dG-N2 adducts with carcinogenic amino-/nitroarenes. (2006)
  • Author(s): T.Takamura-Enya, et al.
  • Journal Title: J. Org. Chem 71 Pages: 5599-5606
• [Journal Article] DNA damage and acute toxicity caused by the urban air pollutant 3-nitrobenzanthrone in rats : characterization of DNA adducts in eight different tissues and organs with synthesized standards. (2006)
  • Author(s): Ester Nagy, et al.
  • Journal Title: Environ. Mol. Mutagen 47 Pages: 541-552
• [Journal Article] Chemical synthesis of 2'-deoxyguanosine-C8 adducts with heterocyclic amines : an application to synthesis of oligonucleotides site-specifically adducted with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. (2006)
  • Author(s): T.Takamura-Enya, et al.
  • Journal Title: Chem. Res. Toxicol. 19 Pages: 770-778
• [Journal Article] Cytochrome P450 ZE1/ZA6-selective inhibition by halogenated anilines on metabolic activation of dimethylnitrosamine in human liver microsomes (2006)
  • Author(s): Y.Ohashi et al.
  • Journal Title: Journal of Health Science 52 Pages: 623-627
• [Journal Article] Identification of three major DNA adducts formed by the mutagenic air pollutant 3-nitrobenzanthrone in rat lung at the C8 and N2 position of guanine and at the N6 position of adenine. (2006)
  • Author(s): Volker M Arlt, et al.
  • Journal Title: Int. J. Cancer 118 Pages: 2139-2146
• [Presentation] 質量分析器、次世代DNAシーケンサーの変異原研究への応用可能性 (2010)
  • Author(s): 松田知成
  • Organizer: 日本環境変異原学会(JEMS)第39回大会
  • Place of Presentation: つくば
• [Presentation] 質量分析器、次世代DNAシーケンサーの変異原研究への応用可能性 (2010)
  • Author(s): 松田知成
  • Organizer: 日本環境変異原学会(JEMS)
  • Place of Presentation: つくば国際会議場
• [Presentation] 過酸化脂質によるDNA損傷 (2009)
  • Author(s): 松田知成
  • Organizer: レドックス生命科学第170委員会 第20回研究会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-03-23
• [Presentation] Significance of DNA adductome analysis in in vitro micronucleus test (2009)
  • Author(s): Muto, S., Kato, K., Yamamura, E., Kawanishi, M., Yagi, T., Matsuda T., Sugiyama, A., Uno, Y.
  • Organizer: In 10th International Conference on Environmental Mutagens (ICEM)
  • Place of Presentation: イタリア、フィレンツェ
• [Presentation] ALDH2 genotype is critical for DNA adducts formation in mice treated with alcohol and acetaldehyde (2009)
  • Author(s): Matsuda T., Nagayoshi, H., Oka, M., Yukawa, Y., Hori, K., Kawamoto, T., Muto, M., Oyama, T.
  • Organizer: In 10th International Conference on Environmental Mutagens (ICEM)
  • Place of Presentation: イタリア,フィレンツェ
• [Presentation] ALDH2 genotype is critical for DNA adducts formation in mice treated with alcohol and acetaldehyde. (2009)
  • Author(s): Matsuda T, Nagayoshi H, Oka M, et al.
  • Organizer: 10th International Conference on Environmental Mutagens (ICEM)
  • Place of Presentation: Firenze, Italy
• [Presentation] Significance of DNA adductome analysis in in vitro micronucleus test (2009)
  • Author(s): Muto S, Kato K, Yamamura E, et al.
  • Organizer: 10th International Conference on Environmental Mutagens (ICEM)
  • Place of Presentation: Firenze, Italy.
• [Presentation] Approach to toxicity evaluation of C60 fullerene using several in vitro methods (2009)
  • Author(s): Matsuda S, Matsui S, Matsuda T.
  • Organizer: 10th International Conference on Environmental Mutagens (ICEM)
  • Place of Presentation: Firenze, Italy.
• [Presentation] Child-adult differences in evaluation of in vivo genotoxicity of acrylamide. (2009)
  • Author(s): Koyama N, Kimura A, Yasui M, et al
  • Organizer: 10th International Conference on Environmental Mutagens (ICEM)
  • Place of Presentation: Firenze, Italy.
• [Presentation] Formation, DNA repair, and TLS of 3-nitrobenzanthrone-derived DNA adducts. (2009)
  • Author(s): Kawanishi M, Nishida H, Ishii H, et al.
  • Organizer: 10th International Conference on Environmental Mutagens (ICEM)
  • Place of Presentation: Firenze, Italy.
• [Presentation] Frequent incorporation of formaldehyde derived N2-methyl-2'-deoxyguanosine triphosphate into DNA during DNA synthesis catalyzed by bacterial and mammarian DNA polymerase. (2009)
  • Author(s): Ihara M, Yasui M, Matsui S, Shibutani S, Matsuda T.
  • Organizer: 10th International Conference on Environmental Mutagens (ICEM)
  • Place of Presentation: Firenze, Italy.
• [Presentation] Detection of liqid peroxidation-induced DNA adducts caused by 4-oxo-2-nonenal and 4-oxo-2-hexenal in human autopsy tissues. (2009)
  • Author(s): Chou P-H, Kageyama S, Matsuda S, et al.
  • Organizer: 10th International Conference on Environmental Mutagens (ICEM)
  • Place of Presentation: Firenze, Italy.
• [Presentation] Oxidative modificomics analysis of cysteine thiols. (2009)
  • Author(s): Adachi J, Kihara K, Matsuda T.
  • Organizer: 10th International Conference on Environmental Mutagens (ICEM)
  • Place of Presentation: Firenze, Italy.
• [Presentation] VOCにより誘起される含フェニルテルピリジンアルキルホスホン酸エステル/Eu(III)/Si02複合体の発光変化 (2009)
  • Author(s): 牧岡良和, 谷口裕樹, 近藤正樹, 高村岳樹
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 船橋市
• [Presentation] イオン液体中で調製した酸化バナジウムナノゲルの抗菌活性、 (2009)
  • Author(s): 谷口裕樹, 牧岡良和, 高石優太, 高村岳樹
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 船橋市
• [Presentation] 相模川水系における変異原性物質および内分泌撹乱物質の分析 (2009)
  • Author(s): 高村岳樹, 大井川はるな, 白石不二雄, 小田美光
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 船橋市
• [Presentation] 含フェニルテルピリジンアルキルホスホン酸エステル/Eu (III)/Si02複合体の光物性 (2009)
  • Author(s): 近藤正樹, 牧岡良和, 谷口裕樹, 高村岳樹
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 船橋市
• [Presentation] UMUテストによる光遺伝毒性物質の検出 (2009)
  • Author(s): 高村岳樹, 斎藤寛之, 小田美光
  • Organizer: 日本薬学会129年会
  • Place of Presentation: 京都
• [Presentation] クロルキノリン類のヒトCYP分子種選択的蛍光プローブとしての有用性 (2009)
  • Author(s): 佐伯憲一, 崔欣鶴, 木村和哲
  • Organizer: 日本薬学会129年会
  • Place of Presentation: 京都
• [Presentation] エタノール摂取によるアルデヒド脱水素酵素2ノックアウトマウスの生存率とDNA障害 (2009)
  • Author(s): 小山倫浩, 一瀬豊日, PHAM Thi Thu Phuong, 山口哲右, 欅田尚樹, 永吉晴奈, 松田知成, 川本俊弘
  • Organizer: 第8回分子予防環境医学研究会
  • Place of Presentation: 東京
• [Presentation] DNA adductomics : global survey of DNA damage in human tissues. (2008)
  • Author(s): Matsuda T., Kanaly, R.A., Chou, P.H.
  • Organizer: ECNIS WP6 workshop on new developments : biomarkers of complex mixtures and use of 'omics' technology.
  • Place of Presentation: クロアチア,ツァヴタット
  • Year and Date: 2008-09-21
• [Presentation] DNA adductomics : global survey of DNA damage in human tissues (2008)
  • Author(s): Tomonari Matsuda, Robert A. Kanaly and Pei-His Chou
  • Organizer: ECNIS WP6 workshop on new developments : biomarkers of complex mixtures and use of 'omics' technology
  • Place of Presentation: Cavtat, Croatia
  • Year and Date: 2008-09-21
• [Presentation] DNA adductomics : global survey of DNA damage in human tissues. (2008)
  • Author(s): Tomonari Matsuda, Robert A. Kanaly, Pei-Hsin Chou
  • Organizer: ECNIS WP6 workshop on new developments
  • Place of Presentation: カビテット(クロアチア)
  • Year and Date: 2008-09-21
• [Presentation] 大気汚染物質3-ニトロベンズアントロンによるDNA 付加体の生成とTLS・突然変異 (2008)
  • Author(s): 川西優喜, 西田裕, 石井宏, 菅野毅治,Robert Fuchs, 松田知成, 高村岳樹, 八木孝司
  • Organizer: 第31回日本分子生物学会年会
  • Place of Presentation: 神戸
• [Presentation] Significance of DNA adductome analysis in vitro micronucleus test (2008)
  • Author(s): Kyoko Kato, Eiji Yamamura, Masanobu Kawanishi, Takashi Yagi, Tomonari Matsuda, Akio Sugiyama, Yoshifumi Uno
  • Organizer: 第37回日本環境変異原学会
  • Place of Presentation: 沖縄
• [Presentation] Detection of 4-OHE-DNA adducts in human lung tissue (2008)
  • Author(s): Kazuaki Kawai, Pei-Hsin Chou, Masaaki Inoue, Tomonari Matsuda, Hiroshi Kasai
  • Organizer: 第37回日本環境変異原学会
  • Place of Presentation: 沖縄
• [Presentation] Distribution of Acetaldehyde and DNA Adducts in Aldehyde Dehydrogenase 2-knockout Mice after Intraperitoneal Administration of Ethanol (2008)
  • Author(s): Yoshiyuki Yukawa, M Muto, K. Hori, Y. Ezoe, S. Arai, H. Nagayoshi, T. Matsuda, T. Oyama, T. Chiba
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] DNAアダクト-ム解析による過酸化脂質由来DNA塩基損傷の網羅的解析 (2008)
  • Author(s): 松田知成、周佩欣、河井一郎、葛西宏
  • Organizer: 第61回日本酸化ストレス学会学術集会
  • Place of Presentation: 京都
• [Presentation] LC/MS/MSを用いたDNA損傷研究法 (2008)
  • Author(s): 松田知成
  • Organizer: 第35回BMSコンファレンス
  • Place of Presentation: 福島県
• [Presentation] Analysis of DNA adducts in the lung of mice exposed to multi-wall carbon nanotube (MWCNT) (2008)
  • Author(s): Tomonari Matsuda, Ryuhei Nishi, Yukari Totsuka, Keiji Wakabayashi
  • Organizer: 環境ホルモン学会第11回研究発表会
  • Place of Presentation: 東京
• [Presentation] 大気汚染物質3-ニトロベンズアントロンによるDNA付加体の生成とTLS・突然変異 (2008)
  • Author(s): 川西優喜, 西田裕, 石井宏, 菅野毅治, Robert Fuchs, 松田知成, 高村岳樹, 八木孝司
  • Organizer: 第31回日本分子生物学会年会
  • Place of Presentation: 神戸
• [Presentation] Significance of DNA adductome analysis in vitro micronucleus test. (2008)
  • Author(s): Kyoko Kato, Eiji Yamamura, Masanobu Kawanishi, Takashi Yagl, Tomonari Matsuda, Akio Sugiyama, Yoshifuml Uno
  • Organizer: 第37回日本環境変異原学会
  • Place of Presentation: 沖縄
• [Presentation] Detection of 4-OHE-DNA adducts in human lung tissue. (2008)
  • Author(s): Kazuaki Kawai, Pei-H-in Chou, MasaakiIn oue, Tomonari Matsuda, Hiroshi Kasai
  • Organizer: 第37回日本環境変異原学会
  • Place of Presentation: 沖縄
• [Presentation] Detection and evaluation of DNA adducts in human pancreas and spleen by the DNA adductomics methodology. (2008)
  • Author(s): Robert A. Kanaly, Pei-Hsin Chou, Haruna Nagayoshi, Haruhiko Sugimura, Tomonari Matsuda
  • Organizer: 第37回日本環境変異原学会
  • Place of Presentation: 沖縄
• [Presentation] Child-adult differences in evaluation of in vivo genotoxicity of acrylamide. (2008)
  • Author(s): Naoki Koyama, Aoi Kimura, Manabu Yasui, Shigeaki Takami. Miwa Takahashi, Toshio Imai, Ayumi Yamamoto, Wakako Kumita, Kenichi Masumura, Shuichi Matsuda, Naohide Kinae, Tomonari Matsuda, Takehiko Nohomi, Masamitsu Honma
  • Organizer: 第37回日本環境変異原学会
  • Place of Presentation: 沖縄
• [Presentation] Unbiased Quantification of oxidative modifications of cysteine thiols by double labeling approach using isotope amino acids and affinity tags (DLIAA). (2008)
  • Author(s): Jun Adachi, Keishi Kihara, Tomonari Matsuda
  • Organizer: 第37回日本環境変異原学会
  • Place of Presentation: 沖縄
• [Presentation] Analysis of DNA adducts in the lung of mice exposed to multi-wall carbon nanotube. (2008)
  • Author(s): Ryuhei Nishi, Yukari Totsuka, Keiji Wakabayashi, Toraonari Matsuda
  • Organizer: 第37回日本環境変異原学会
  • Place of Presentation: 沖縄
• [Presentation] Inhibition of Benzo[a]pyrene-DNA adducts by chrysoeriol, a dietary methoxyflavonoid, in MCF-7 cells. (2008)
  • Author(s): Hitomi Takemura, Asako Matsui, Maki Morita, Hiroyuki Sakakibara, Tomonari Matsuda, Kayoko Shimoi
  • Organizer: 第37回日本環境変異原学会
  • Place of Presentation: 沖縄
• [Presentation] Availability of DNA damage, N2-ethylidene-dG as a biomarker of acetakdehyde exposure. (2008)
  • Author(s): Haruna Nagayoshi, Megumi Oka, Yoshiyuki Yukawa, Kimiko Hori, Yoshihide Suwa, Akira Yokoyama, Manabu Muto, Tomonari Matsuda
  • Organizer: 第37回日本環境変異原学会
  • Place of Presentation: 沖縄
• [Presentation] Simultaneous analysis of various oxidative DNA adducts in human tissues using LC-MS/MS (2008)
  • Author(s): Pei-Hsin Chou, Haruhiko Sugimura, KazuakiKawai, Hiroshi Kasai, Tomonari Matsuda
  • Organizer: 第37回日本環境変異原学会
  • Place of Presentation: 沖縄
• [Presentation] Agonistic and Antagonistic Activities of various Chemicals in Reporter Yeasts Expressing Estrogen Receptors α and β (2008)
  • Author(s): Wai-Ling Chu, Kazuhiro Shi izaki, Masanobu Kawanishi, Takashi Yagi
  • Organizer: 第37回日本環境変異原学会
  • Place of Presentation: 沖縄
• [Presentation] Efficiency and Fidelity of Translesion DNA Synthesis across 3-nitrobenzanthrone-DNA-adducts (2008)
  • Author(s): Hiroshi Nishida, Masanobu Kawanishi, Takeji Takamura, Takashi Yagi
  • Organizer: 第37回日本環境変異原学会
  • Place of Presentation: 沖縄
• [Presentation] Quantitative Analysis of Translesion DNA Synthesis across Site-specific 4-Aminobiphenyl Adducts in Human Cells (2008)
  • Author(s): Tomoko Sawai, Mawanobu Kawanishi, Takaharu Kanno, Takeji Takamura-Enta, Takashi Yagi
  • Organizer: 第37回日本環境変異原学会
  • Place of Presentation: 沖縄
• [Presentation] Evaluation of Endocrine Disruptors Using Reporter Yeasts Expressing Human Androgen Receptor and Thyroid Hormone Receptor (2008)
  • Author(s): Shingo Ebata, Shota Asai, Kazuhiro Shiizaki, Masanobu Kawanishi, Takashi Yagi
  • Organizer: 第37回日本環境変異原学会
  • Place of Presentation: 沖縄
• [Presentation] Evaluation of Genotoxicity of 3, 6 Dinitrobenzo[e]pyrene in Human Cell Lines, Soichiro Hagio (2008)
  • Author(s): Sayaka Ogo, Masanobu Kawanishi, Tetsushi Watanabe, Yoshimitsu Oda, Takashi Yagi
  • Organizer: 第37回日本環境変異原学会
  • Place of Presentation: 沖縄
• [Presentation] TCDD Represses Benzo[a]pyrene-DNA Adduct Formation in HepG2 cell (2008)
  • Author(s): Kazuhiro Shiizaki, Masanobu Kawanishi, Takashi Yagi
  • Organizer: 第37回日本環境変異原学会
  • Place of Presentation: 沖縄
• [Presentation] Genotoxicity of Nanomaterials (2008)
  • Author(s): Sayaka Ogo, Masanobu Kawanishi, Yukari Totsuka, Keiji Wakabayashi, Takashi Yagi
  • Organizer: 第37回日本環境変異原学会
  • Place of Presentation: 沖縄
• [Presentation] 4-Oxo-2-hexenal-dA adduct formation in DNA in vitro and in mouse organs (2008)
  • Author(s): Kazuaki Kawai, Pei-Hsin Chou, TomonariMatsuda, Saburo Matsui, Hiroshi Kasai
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] Distribution of Acetaldehyde and DNA Adducts in Aldehyde Dehydrogenase 2-knockout Mice after Intraperitoneal (2008)
  • Author(s): Yoshiyuki Yukawa, M. Muto, K. Hori, Y. Ezoe, S. Arai, H. Nagayoshi, T. Matsuda, T. Oyama, T. Chiba
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] DNAアダクトーム解析による過酸化脂質由来DNA塩基損傷の網羅的解析 (2008)
  • Author(s): 松田知成, 周佩欣, 河井一郎, 葛西宏
  • Organizer: 第61回日本酸化ストレス学会学術集会
  • Place of Presentation: 京都
• [Presentation] HPLC-バイオアッセイ法による新規環境汚染物質の単離同定 (2008)
  • Author(s): 松田知成, 周佩欣, 永吉晴奈
  • Organizer: 第17回環境化学討論会
  • Place of Presentation: 神戸
• [Presentation] Comparison of Cumulative DNA Damage in Human Organs by the Newly Developing Adductome Approach (2007)
  • Author(s): Nagayoshi H, Kanaly R, Matsuda T
  • Organizer: 4th Joint Meeting of the Society for Free Radical Research Australasia and Japan
  • Place of Presentation: 京都市
  • Year and Date: 2007-12-03
• [Presentation] Utilization of the adductome approach to assess DNA damage in human liver tissue. (2007)
  • Author(s): Kanaly R. A., Matsuda T, et. al.
  • Organizer: 1st Asian Conference on Environmental Mutagens and 36th Annual Meeting of the Japanese Environmental Mutagen Society
  • Place of Presentation: 北九州市
  • Year and Date: 2007-11-30
• [Presentation] Analysis of DNA adducts derived from N-nitroso bile acid conjugates in rat duodenogastric reflux model. (2007)
  • Author(s): Nishimura K, Matsuda T, et. al.
  • Organizer: 1st Asian Conference on Environmental Mutagens and 36th Annual Meeting of the Japanese Environmental Mutagen Society
  • Place of Presentation: 北九州市
  • Year and Date: 2007-11-30
• [Presentation] AhR Activation and Metabolic Degradation of Quinoline DisperseDyes-Disperse Yellow 54 and Disperse Yellow 64 (2007)
  • Author(s): Chou P, Matsuda T, et. al.
  • Organizer: 1st Asian Conference on Environmental Mutagens and 36th Annual Meeting of the Japanese Environmental Mutagen Society
  • Place of Presentation: 北九州市
  • Year and Date: 2007-11-30
• [Presentation] The behavior of DNA-damaging agents and AhR ligands in petrochemical industrial wastewater treatment plant. (2007)
  • Author(s): Nishi R, Matsuda T, et. al.
  • Organizer: 1st Asian Conference on Environmental Mutagens and 36th Annual Meeting of the Japanese Environmental Mutagen Society
  • Place of Presentation: 北九州市
  • Year and Date: 2007-11-30
• [Presentation] A selective inhibitor of CYP1B1, chrysoeriol. (2007)
  • Author(s): Takemura H, Matuda T, et. al.
  • Organizer: 1st Asian Conference on Environmental Mutagens and 36th Annual Meeting of the Japanese Environmental Mutagen Society
  • Place of Presentation: 北九州市
  • Year and Date: 2007-11-30
• [Presentation] The effect of CYP1A1 on AhR ligand activity using novelyeast reporter gene assay system (2007)
  • Author(s): Nagayoshi H, Matsuda T, et. al.
  • Organizer: 1st Asian Conference on Environmental Mutagens and 36th Annual Meeting of the Japanese Environmental Mutagen Society
  • Place of Presentation: 北九州市
  • Year and Date: 2007-11-30