Structures and Functions of Membrane-Bound Biomolecules

• Project/Area Number: 18101010
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Living organism molecular science
• Research Institution: Osaka University
• Principal Investigator: MURATA Michio Osaka University, 大学院・理学研究科, 教授 (40183652)
• Co-Investigator(Kenkyū-buntansha): OISHI Tohru 九州大学, 大学院・理学研究院, 教授 (90241520) ; MATSUMORI Nobujaki 大阪大学, 大学院・理学研究科, 准教授 (50314357) ; DOI Mototsugu 大阪大学, 大学院・理学研究科, 技術補佐員 (10379307)
• Project Period (FY): 2006 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥110,630,000 (Direct Cost: ¥85,100,000、Indirect Cost: ¥25,530,000); Fiscal Year 2010: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000); Fiscal Year 2009: ¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000); Fiscal Year 2008: ¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000); Fiscal Year 2007: ¥26,910,000 (Direct Cost: ¥20,700,000、Indirect Cost: ¥6,210,000); Fiscal Year 2006: ¥37,960,000 (Direct Cost: ¥29,200,000、Indirect Cost: ¥8,760,000)
• Keywords: 脂質二重膜 / 抗生物質 / 脂質マイクロドメイン / 分子複合体自己会合体 / コレステロール / 膜タンパク質 / 脂質ラフト / スフィンゴミエリン / 膜貫通型膜タンペク質 / 固体NMR / イオン透過性チャネル / アンフォテリシンB / 分子複合体 / 生体膜 / 自己会合体 / マイクロドメイン

Research Abstract

Biomembrane, essential entity for life, has been regarded as an elusive liquid medium. In this project, we have examined the 3D structures of membrane lipids which are responsible for biological functions. Solid-state NMR measurements for isotope-labeled molecules allowed us to elucidate the structures and dynamics of antibiotics and phospholipids residing in bilayer membranes.

Research Products

• [Journal Article] Synthesis of 6-F-ergosterol and its influence on membrane-permeabilization of amphotericin B and amphidinol 3. (2011)
  • Author(s): Kasai, Y., Matsumori, N., Ueno, H., Nonomura, K., Yano, S. Murata, M., Oishi, T.
  • Journal Title: Org.Biomol.Chem. 9 Pages: 1437-1442
  • Peer Reviewed
• [Journal Article] Conformations of spermine in ATP complex : The structural basis for weak bimolecular interactions of major cellular electrolytes. (2011)
  • Author(s): Maruyoshi, M., Yamaguchi, T., Demura, T., Matsumori, N., Oishi, T., Murata, M.
  • Journal Title: Chem.Eur.J. 17 Pages: 4788-4795
  • Peer Reviewed
• [Journal Article] Synthesis of 6-F-ergosterol and its influence on membrane-permeabilization of amphotericin B and amphidinol 3. (2011)
  • Author(s): Kasai, Y., Matsumori, N., Ueno, H., Nonomura, K., Yano, S., Murata, M., Oishi, T.
  • Journal Title: Org.Biomol.Chem. Volume: 9 Pages: 1437-1442
  • Peer Reviewed
• [Journal Article] effect on interaction between amphidinol 3 and liposomal membrane as evidenced by surface plasmon resonance. (2010)
  • Author(s): Swasono, R., Mouri, R., Morsy, N., Matsumori, N., Oishi, T., Murata, M.Sterol
  • Journal Title: Bioorg.Med.Chem.Lett. 20 Pages: 2215-2218
  • Peer Reviewed
• [Journal Article] Identification of Rap1A as yessotoxin binding target from blood cell membranes. (2010)
  • Author(s): Ujihara, S., Oishi, T., Mouri, R., Tamate, R., Konoki, K., Matsumori, N., Murata, M., Oshima, Y., Sugiyama, N., Tomita, M., Ishihama, Y.
  • Journal Title: Bioorg.Med.Chem.Lett. 20 Pages: 6443-6446
  • Peer Reviewed
• [Journal Article] Sterol effect on interaction between amphidinol 3 and liposomal membrane as evidenced by surface plasmon resonance. (2010)
  • Author(s): Swasono, R., Mouri, R., Morsy, N., Matsumori, N., Oishi, T., Murata, M.
  • Journal Title: Bioorg.Med.Chem.Lett. Volume: 20 Pages: 2215-2218
  • Peer Reviewed
• [Journal Article] Identification of RaplA as yessotoxin binding target from blood cell membranes. (2010)
  • Author(s): Ujihara, S., Oishi, T., Mouri, R., Tamate, R., Konoki, K., Matsumori, N., Murata, M., Oshima, Y., Sugiyama, N., Tomita, M., Ishihama, Y.
  • Journal Title: Bioorg.Med.Chem.Lett. Volume: 20 Pages: 6443-6446
  • Peer Reviewed
• [Journal Article] Conformational change of spermidine upon interacting with ATP in aqueous solution. (2009)
  • Author(s): Maruyoshi, K., Nonaka, K., Sagane, T., Demura, T., Yamaguchi, T., Matsumori, N., Oishi, T., Murata, M
  • Journal Title: Chem.Eur.J. 15 Pages: 1618-1626
  • Peer Reviewed
• [Journal Article] interaction between amphotericin B and ergosterol in lipid bilayers as revealed by 2H (2009)
  • Author(s): Matsumori, N., Tahara, K., Yamamoto, H., Morooka, A., Doi, M., Oishi, T., Murata, M.Direct
  • Journal Title: NMR.J.Am.Chem.Soc. 131 Pages: 11855-11860
  • Peer Reviewed
• [Journal Article] Surface resonance-based detection of ladder-shaped polyether by competitive binding method. (2009)
  • Author(s): Mouri, R., Oishi, T., Torikai, K., Ujihara, S., Matsumori, N., Murata, M., Oshima, Y.
  • Journal Title: Bioorg.Med.Chem.Lett. 19 Pages: 2824-2828
  • Peer Reviewed
• [Journal Article] Amphotericin B-induced ion flux is markedly attenuated in phosphatidylglycerol membrane as evidenced by a newly devised fluorometric method. (2009)
  • Author(s): Takano, T., Konoki, K., Matsumori, N., Murata, M.
  • Journal Title: Bioorg.Med.Chem. 17 Pages: 6301-6304
  • Peer Reviewed
• [Journal Article] Direct interaction between amphotericin B and ergosterol in lipid bilayers as revealed by ^2H NMR. (2009)
  • Author(s): Matsumori, N., Tahara, K., Yamamoto, H., Morooka, A., Doi, M., Oishi, T.Murata, M.
  • Journal Title: J.Am.Chem.Soc. 131 Pages: 11855-11860
  • Peer Reviewed
• [Journal Article] Ion channel complex of antibiotics as viewed by NMR. (2009)
  • Author(s): Murata, M., Kasai, Y., Umegawa, Y., Matsushita, N., Tsuchikawa, H., Matsumori, M.Oishi, T.
  • Journal Title: Pure Appl.Chem. 81 Pages: 1123-1129
  • Peer Reviewed
• [Journal Article] Amphotericin B-induced in flux is markedly attenuated in phosphatidylglycerol membrane as evidenced by a newly devised flurometric method. (2009)
  • Author(s): Takano, T., Konoki, K., Matsumori, N., Murata, M.
  • Journal Title: Bioorg.Med.Chem. 17 Pages: 6301-6304
  • Peer Reviewed
• [Journal Article] Synthesis of 25-^<13>C-amphotericin B methyl ester : a molecular probe for solid-state NMR measurements. (2009)
  • Author(s): Matsushita, N., Matsuo, Y., Tsuchikawa, H.Matsumori, N., Murata, M., Oishi, T.
  • Journal Title: Chem.Lett. 38 Pages: 114-115
  • NAID: 10025118860
  • Peer Reviewed
• [Journal Article] Conformational change of spermidine upon interacting with adenosine triphosphate in aqueous solution. (2009)
  • Author(s): Marayoshi, K., Nonaka, K., Sagane, T., Demura, T., Yamaguchi, T., Matsumori, N., Oishi, T., Murata, M.
  • Journal Title: Chem. Eur. J. 15 Pages: 1618-1626
  • Peer Reviewed
• [Journal Article] Synthesis of 25-^<13> C-amphotericin B methyl ester : a molecular probe for solid-state NMR measurements. (2009)
  • Author(s): Matsushita, N., Matsuo, Y., Tsuchikawa, H. Matsumori, N., Murata, M., Oishi, T.
  • Journal Title: Chem. Lett. 38 Pages: 114-115
  • NAID: 10025118860
  • Peer Reviewed
• [Journal Article] Design, synthesis, and biological evaluation of fluorinated analogs of salicylihalamide. (2009)
  • Author(s): Sugimoto, Y., Konoki, K., Murata, M., Matsushita, M., Kanazawa, H., Oishi, T.
  • Journal Title: J. Med. Chem. 52 Pages: 798-806
  • Peer Reviewed
• [Journal Article] Self-assembly of amphotericin B is probably surrounded by ergosterol; bimolecular interactions as evidenced by solid stata NMR and CD spectra. (2008)
  • Author(s): Kasai, Y., Matsumori, N., Umegawa, Y., Matsuoka, S., Ueno, H., Ikeuchi, H., Oishi, T., Murata, M.
  • Journal Title: Chem.Eur.J. 14 Pages: 1178-1185
  • Peer Reviewed
• [Journal Article] Effects of lipid constituents on membrane-permeabilizing activity of amphidinols. (2008)
  • Author(s): Morsy, N., Houdai, T., Konoki, K., Matsumori, N., Oishi, T., Murata, M
  • Journal Title: Bioorg.Med.Chem. 16 Pages: 3084-3090
  • Peer Reviewed
• [Journal Article] Roles of integral protein in membrane permeabilization by amphidinols. (2008)
  • Author(s): Morsy, N., Konoki, K., Houdai, T., Matsumori, N.Oishi, T., Murata, M., Aimoto, S.
  • Journal Title: Biochim.Biophys.Acta. 1778 Pages: 1453-1459
  • Peer Reviewed
• [Journal Article] Orientation of fluorinated cholesterol in lipid bilayers analyzed by 19F tensor calculation and solid-state NMR. (2008)
  • Author(s): Matsumori, N., Kasai, Y., Oishi, T., Murata, M., Nomura, K.
  • Journal Title: J.Am.Chem.Soc. 130 Pages: 4757-4766
  • Peer Reviewed
• [Journal Article] Complex formation of amphotericin B in sterol-containing membrane as evidenced by surface plasmon resonance. (2008)
  • Author(s): Mouri, R., Konoki, K., Matsumori, N., Oishi, T., Murata, M.
  • Journal Title: Biochemistry 47 Pages: 7807-7815
  • Peer Reviewed
• [Journal Article] Design and synthesis of ladder-shaped tetracyclic, heptacyclic, and decacyclic ethers and evaluation of the interaction with transmembrane proteins. (2008)
  • Author(s): Torikai, K., Oishi, T., Ujihara, S., Matsumori,N., Koniki, K.Murata, M., Aimoto, S.
  • Journal Title: J.Am.Chem.Soc. 30 Pages: 10217-10226
  • Peer Reviewed
• [Journal Article] Structure of membrane-bound amphidinol 3 in isotropic small bicelles. (2008)
  • Author(s): Houdai, T., Matsumori, N., Murata, M.
  • Journal Title: Org.Lett. 10 Pages: 4191-4194
  • Peer Reviewed
• [Journal Article] Interaction of ladder-shaped polyethers with transmembrane α-helix of glycophorin A as evidenced by saturation transfer difference NMR and surface plasmon resonace. (2008)
  • Author(s): Ujihara, S., Oishi, T., Torikai, K., Konoki, K., Matsumori, N., Murata, M., Oshima, Y., Aimoto, S.
  • Journal Title: Bioorg.Med.Chem.Lett. 18 Pages: 6115-6118
  • Peer Reviewed
• [Journal Article] Ergosterol increases intermolecular distance of amphotericin B in membrane-bound assembly as evidenced by solid-state NMR. (2008)
  • Author(s): Umegawa, Y., Matsumori, N., Oishi, T.,Murata, M.
  • Journal Title: Biochemistry 47 Pages: 13463-13469
  • Peer Reviewed
• [Journal Article] Self-assembly of amphotericin B is probably surrounded by ergosterol ; bimolecular interactions as evidenced by solid state NMR and CD spectra (2008)
  • Author(s): Kasai Y., Matsumori N., Umegawa Y., Matsuoka S., Ueno H., Ikeuchi H., Oishi T. and Murata M
  • Journal Title: Chem. Eur. J. 14 Pages: 1178-1185
• [Journal Article] Orientation of fluorinated cholesterol in lipid bilayers analyzed by ^<19>F tensor calculation and solid-state NMR (2008)
  • Author(s): Matsumori N., Kasai Y., Oishi T., Murata M. and Nomura K.
  • Journal Title: J. Am. Chem. Soc. 130 Pages: 4757-4766
• [Journal Article] Complex formation of amphotericin B in sterol-containing membrane as evidenced by surface plasmon resonance (2008)
  • Author(s): Mouri R., Konoki K., Matsumori N., Oishi T. and Murata M.
  • Journal Title: Biochemistry 47 Pages: 7807-7815
• [Journal Article] Ergosterol increases intermolecular distance of amphotericin B in membrane-bound assembly as evidenced by solid-state NMR (2008)
  • Author(s): Umegawa Y., Matsumori N., Oishi T. and Murata M.
  • Journal Title: Biochemistry 47 Pages: 13463-13469
• [Journal Article] Orientation of fluorinated cholesterol in lipid bilayers analyzed by ^<19>F tensor calculation and solid-state NMR. (2008)
  • Author(s): Matsumori, N., Kasai, Y., Oishi, T., Murata, M., Nomura, K.
  • Journal Title: J. Am. Chem. Soc. 130 Pages: 4757-4766
  • Peer Reviewed
• [Journal Article] Design and synthesis of ladder-shaped tetracyclic, heptacyclic, and decacyclic ethers and evaluation of the interaction with transmembrane proteins. (2008)
  • Author(s): Torikai, K., Oishi, T., Ujihara, S., Matsumori, N., Koniki, K. Murata, M., Aimoto, s.
  • Journal Title: J. Am. Chem. Soc. 30 Pages: 10217-10226
  • Peer Reviewed
• [Journal Article] Convergent synthesis and biological activity of the WXYZA'B'C' ring system of maitotoxin. (2008)
  • Author(s): Oishi, T., Hasegawa, F., Torikai, K., Konoki, K., Matsumori, N., Murata, M.
  • Journal Title: Org. Lett. 10 Pages: 3599-3602
  • Peer Reviewed
• [Journal Article] Structure of membrane-bound amphidinol 3 in isotropic small bicelles. (2008)
  • Author(s): Houdai, T., Matsumori, N., Murata, M.
  • Journal Title: Org. Lett. 10 Pages: 4191-4194
  • Peer Reviewed
• [Journal Article] Accurate measurement of vicinal carbon-hydrogen coupling constants via ammonium nitrogen based on HMBC experiments. (2008)
  • Author(s): Yamaguchi, T., Maruyoshi, K., Matsumori, N., Murata, M.
  • Journal Title: Chem. Lett. 37 Pages: 1172-1173
  • NAID: 10024397270
  • Peer Reviewed
• [Journal Article] Convergent synthesis of the A-J ring system of yessotoxin. (2008)
  • Author(s): Torikai, K., Watanabe, K., Minato, H., Imaizumi, T., Murata, M., Oishi, T.
  • Journal Title: Synlett. Pages: 2368-2372
  • Peer Reviewed
• [Journal Article] Ascidian sperm activating and attracting factor : importance of sulfate groups for the activities and implication of its putative receptor. (2008)
  • Author(s): Yoshida, M., Shiba, K., Yoshida, K., Tsuchikawa, H., Ootou, O., Oishi, T., Murata, M.
  • Journal Title: FEBS Lett. 582 Pages: 3429-3433
  • Peer Reviewed
• [Journal Article] Valosin-containing protein (VCP)/p97 interacts with SAAF in the ascidian egg and modulates sperm-attracting activity. (2008)
  • Author(s): Kondoh, E., Konno, A., Inaba, K., Oishi, T., Murata, M., Yoshida, M.
  • Journal Title: Develop. Grow. Differ. 50 Pages: 665-673
  • Peer Reviewed
• [Journal Article] Interaction of ladder-shaped polyethers with transmembrane α-helix of glycophorin A as evidenced by saturation transfer difference NMR and surface plasmon resonace. (2008)
  • Author(s): Ujihara, S., Oishi, T., Torikai, K., Konoki, K., Matsumori, N., Murata, M., Oshima, Y, Aimoto, S.
  • Journal Title: Bioorg. Med. Chem. Lett. 18 Pages: 6115-6118
  • Peer Reviewed
• [Journal Article] Combinatorial synthesis of 1,5-polyol system based on cross metathesis : Structure revision of amphidinol 3. (2008)
  • Author(s): Oishi, T., Kanemoto, M., Swasono, R., Matsumori, N., Murata, M.
  • Journal Title: Org. Lett. 10 Pages: 5203-5206
  • Peer Reviewed
• [Journal Article] Ergosterol increases intermolecular distance of amphotericin B in membrane-bound assembly as evidenced by solid-state NMR. (2008)
  • Author(s): Umegawa, Y., Matsumori, N., Oishi, T., Murata, M.
  • Journal Title: Biochemistry 47 Pages: 13463-13469
  • Peer Reviewed
• [Journal Article] Self-assembly of amphotericin B is probably surrounded by ergosterol; bimolecular interactions as evidenced by solid stata NMR and CD spectra. (2008)
  • Author(s): Kasai, Y., Matsumori, N., Umegawa, Y., Matsuoka, S., Ueno, H., Ikeuchi, H., Oishi, T. and Murata, M.
  • Journal Title: Chem. Eur. J. 14 Pages: 1178-1185
  • Peer Reviewed
• [Journal Article] Roles of integral protein in membrane permeabilization by amphidinols. (2008)
  • Author(s): Morsy, N., Konoki, K., Houdai, T., Matsumori, N. Oishi, T., Murata, M. and Aimoto, S.
  • Journal Title: Biochim. Biophys. Acta. (印刷中)
  • Peer Reviewed
• [Journal Article] Effects of lipid constituents on membrane-permeabilizing activity of amphidinols. (2008)
  • Author(s): Morsy, N., Houdai, T., Konoki, K., Matsumori, N., Oishi, T. Murata, M.
  • Journal Title: Bioorg. Med. Chem. (印刷中)
  • Peer Reviewed
• [Journal Article] Structural Features of Dinoflagellate Toxins Underlying Biological Activity as Viewed by NMR. (2008)
  • Author(s): Murata, M., Matsumori, N., Konoki, K. and Oishi, T.
  • Journal Title: Bull. Chem. Soc. Jpn. (印刷中)
  • NAID: 10021073872
  • Peer Reviewed
• [Journal Article] Conformation and position of membrane-bound amphotericin B deduced from NMR in SDS micelles. (2007)
  • Author(s): Matsumori, N., Houdai, T., Murata, M.
  • Journal Title: J.Org.Chem. 72 Pages: 700-704
  • Peer Reviewed
• [Journal Article] Conformation and location of membrane-bound salinomycin-sodium complex deduced from NMR in isotropic bicelles. (2007)
  • Author(s): Matsumori, N.Morooka, A., Murata, M.
  • Journal Title: J.Am.Chem.Soc. 129 Pages: 14889-14995
  • Peer Reviewed
• [Journal Article] Conformation and position of membrane-bound amphotericin B deduced from NMR in SDS micelles (2007)
  • Author(s): Matsumori N., Houdai T. and Murata M.
  • Journal Title: J. Org. Chem. 72 Pages: 700-704
• [Journal Article] Conformation and position of membrane-bound amphotericin B deduced from NMR in SDS micelles. (2007)
  • Author(s): Matsumori, N., Houdai, T. and Murata, M.
  • Journal Title: J. Org. Chem. 72 Pages: 700-704
  • Peer Reviewed
• [Journal Article] Conformation and Location of Membrane-Bound Salinomycin-Sodium Complex Deduced from NMR in Isotropic Bicelles. (2007)
  • Author(s): Matsumori, N. Morooka, A., and Murata, M.
  • Journal Title: J. Am. Chem. Soc. 129 Pages: 14889-14995
  • Peer Reviewed
• [Journal Article] Conformation and position of membrane-bound amphotericin B deduced from NMR in SDS micelles. (2007)
  • Author(s): Matsumori, N., Houdai, T., Murata, M
  • Journal Title: J.Org.Chem. 72 Pages: 700-706
• [Journal Article] Amphotericin B covalent dimers with carbony-amino linkage : a new probe for investigating ion channel assemblies. (2007)
  • Author(s): Umegawa, Y., Matsumori, N., Oishi, T, Murata, M.
  • Journal Title: Tetrahedron Lett. 48(in press)
• [Journal Article] Detailed description on Conformation and Location of Membrane-bound Erythromycin A using Small Bicelle. (2006)
  • Author(s): Matsumori, N., Morooka, A., Murata, M.
  • Journal Title: J.Med.Chem. 49 Pages: 3501-3508
  • Peer Reviewed
• [Journal Article] Membrane interaction of amphotericin B as single-Length assembly examined by solid state NMR for uniformly ^<13>C-enriched Agent. (2006)
  • Author(s): Matsuoka, S., Ikeuchi, H., Umegawa, Y., Matsumori, N., Murata, M.
  • Journal Title: Bioorg.Med.Chem. 14 Pages: 6608-6614
  • Peer Reviewed
• [Journal Article] Synthesis of 28-19F-amphotericn B methyl ester. (2006)
  • Author(s): Tsuchikawa, H., Matsushita, N., Matsumori, N., Murata, M., Oishi, T.
  • Journal Title: Tetrahedron Lett. 47 Pages: 6187-6191
  • Peer Reviewed
• [Journal Article] Membrane interaction of amphotericin B as single-Length assembly examined by solid state NMR for uniformly ^<13>C-enriched Agent. (2006)
  • Author(s): Matsuoka, S., Ikeuchi, H., Umegawa, Y., Matsumori, N., Murata M.
  • Journal Title: Bioorg.Med.Chem. 14 Pages: 6608-6614
• [Journal Article] Structures of new amphidinols with truncated polyhydroxyl chain and their membrane permeabilizing activities. (2006)
  • Author(s): Morsy, N., Houdai, T., Matsuoka, S., Matsumori, N., Adachi, S., Oishi, T., Murata, M., Iwashita, T., Fujita.T
  • Journal Title: Bioorg.Med.Chem. 14 Pages: 6548-6554
• [Journal Article] Large molecular assembly of amphotericin B formed in ergosterol-containing membrane evidenced by solid-state NMR of intramolecular bridged derivative. (2006)
  • Author(s): Matsumori, N., Sawada, Y., Murata, M
  • Journal Title: J.Am.Chem.Soc. 128 Pages: 11977-11984
• [Journal Article] Synthesis of 28-^<19>F-amphotericn B methyl ester. (2006)
  • Author(s): Tsuchikawa, H., Matsushita, N., Matsumori, N., Murata, M., Oishi, T
  • Journal Title: Tetrahedron Lett. 47 Pages: 6187-6191
• [Journal Article] Conformations of spermine in ATP complex : The structural basis for weak bimolecular interactions of major cellular electrolytes.
  • Author(s): Maruyoshi, M., Yamaguchi, T., Demura, T., Matsumori, N., Oishi T., Murata, M.
  • Journal Title: Chem.Eur.J. Volume: (in press 未定)
  • Peer Reviewed
• [Presentation] SSNMR investigations of organic molecules in lipid bilayers : Application to amphotericin B and lipid rafts (2010)
  • Author(s): Nobuaki Matsumori
  • Organizer: The 2010 International Chemical Congress of Pacific Basin Societies.
  • Place of Presentation: 米国ハワイ州、Honolulu
  • Year and Date: 2010-12-16
• [Presentation] Ion Channel Assembly of Small Molecules in Membrane (2009)
  • Author(s): Michio Murata
  • Organizer: 13^<th> Asian Chemical Congress
  • Place of Presentation: Shanghai(CHINA)
  • Year and Date: 2009-09-15
• [Presentation] Molecular Assemblies in Biomembranes as Viewed by Solid State NMR (2008)
  • Author(s): Michio Murata
  • Organizer: Naito Conference Chemical Biology(シャトレーゼガトーキングダム)
  • Place of Presentation: 札幌(招待講演)
• [Presentation] Synthesis of fluorine labeled natural products for solid-state NMR measurements (2008)
  • Author(s): Tohru Oishi
  • Organizer: 236th ACS National Meeting
  • Place of Presentation: Philadelphia, USA(招待講演)
• [Presentation] Natural products forming functional assemblies in biomembrane (2008)
  • Author(s): Michio Murata
  • Organizer: Mona Symposium
  • Place of Presentation: Kingston, JAMAICA(招待講演)
• [Presentation] Ion channel complex of antibiotics as viewed by NMR (2008)
  • Author(s): Michio Murata
  • Organizer: PAC ICOB-6, SCNP-26
  • Place of Presentation: Charlottetown, CANADA(招待講演)
  • Year and Date: 2008-07-17
• [Presentation] Funcitonal Membrane Complexes (2008)
  • Author(s): Steroids as a Key Player in Assembling Michio Murata
  • Organizer: Nakanishi Symposium
  • Place of Presentation: 立教大学(招待講演)
  • Year and Date: 2008-03-28
• [Presentation] Yessotoxin and synthetic polyether models-Interactions with peptides in membrane (2007)
  • Author(s): Michio Murata
  • Organizer: Vth European Conference on Marine Natura Products
  • Place of Presentation: Ischia, ITALY(招待講演)
• [Presentation] Marine cyclic polyethers-their interaction with membrane proteins (2007)
  • Author(s): Michio Murata
  • Organizer: 日米セミナー海洋天然物
  • Place of Presentation: Salt Lake City, USA(招待講演)
• [Presentation] Synthetic studies of yessotoxin (2007)
  • Author(s): Tohru Oishi
  • Organizer: International Symposium on Catalysts and Fine Chemicals
  • Place of Presentation: Nanyang Tech.Univ.Singapore(招待講演)
  • Year and Date: 2007-12-17
• [Presentation] Synthetic studies of natural and artificial ladder-shaped polyethers for exploring biological functions (2006)
  • Author(s): Tohru Oishi
  • Organizer: Sendai Postsymposium of ICOB-5, ISCNP-25
  • Place of Presentation: 仙台国際センター(招待講演)
  • Year and Date: 2006-07-30
• [Book] 広がる核磁気共鳴NMRの世界 (2011)
  • Author(s): 村田道雄(分担執筆)
  • Total Pages: 4
  • Publisher: コロナ社
• [Book] In "Progress in Molecular and Subcellular Biology"(N., Fusetani, A. S. Clare, Eds., Springer-Verlag, Berlin Heidelberg) (2006)
  • Author(s): Murata, M., Oishi, T. and Yoshida, M.
  • Publisher: State-of-Art Methodology of Marine Natural Products Chemistry : Structure Determination with Extremely Small Sample Amounts
• [Book] Progress in Molecular and Subcellular Biology (2006)
  • Author(s): Murata, M., Oishi, T., Yoshida, M.
  • Total Pages: 18
  • Publisher: Springer-Verlag
• [Remarks] ホームページ等
  • URL: http://www.chem.sci.osaka-u.ac.jp/lab/murata/
• [Remarks]
  • URL: http://www.chem.sci.osaka-u.ac.jp/lab/murata/research/index.htm
• [Remarks]
  • URL: http://www.chem.sci.osaka-u.ac.jp/lab/murata/research/index.htm
• [Remarks]
  • URL: http://www.ch.wani.osaka-u.ac.jp/lab/murata
• [Remarks]
  • URL: http://www.chem.sci.osaka-u.ac.jp/lab/murata/research/index.htm
• [Remarks]
  • URL: http://www.chem.sci.osaka-u.ac.jp/lab/murata/research/index.htm