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Structures and Functions of Membrane-Bound Biomolecules

Research Project

Project/Area Number 18101010
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Living organism molecular science
Research InstitutionOsaka University

Principal Investigator

MURATA Michio  Osaka University, 大学院・理学研究科, 教授 (40183652)

Co-Investigator(Kenkyū-buntansha) OISHI Tohru  九州大学, 大学院・理学研究院, 教授 (90241520)
MATSUMORI Nobujaki  大阪大学, 大学院・理学研究科, 准教授 (50314357)
DOI Mototsugu  大阪大学, 大学院・理学研究科, 技術補佐員 (10379307)
Project Period (FY) 2006 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥110,630,000 (Direct Cost: ¥85,100,000、Indirect Cost: ¥25,530,000)
Fiscal Year 2010: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
Fiscal Year 2009: ¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2008: ¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2007: ¥26,910,000 (Direct Cost: ¥20,700,000、Indirect Cost: ¥6,210,000)
Fiscal Year 2006: ¥37,960,000 (Direct Cost: ¥29,200,000、Indirect Cost: ¥8,760,000)
Keywords脂質二重膜 / 抗生物質 / 脂質マイクロドメイン / 分子複合体自己会合体 / コレステロール / 膜タンパク質 / 脂質ラフト / スフィンゴミエリン / 膜貫通型膜タンペク質 / 固体NMR / イオン透過性チャネル / アンフォテリシンB / 分子複合体 / 生体膜 / 自己会合体 / マイクロドメイン
Research Abstract

Biomembrane, essential entity for life, has been regarded as an elusive liquid medium. In this project, we have examined the 3D structures of membrane lipids which are responsible for biological functions. Solid-state NMR measurements for isotope-labeled molecules allowed us to elucidate the structures and dynamics of antibiotics and phospholipids residing in bilayer membranes.

Report

(7 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report   Self-evaluation Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (81 results)

All 2011 2010 2009 2008 2007 2006 Other

All Journal Article (61 results) (of which Peer Reviewed: 50 results) Presentation (11 results) Book (3 results) Remarks (6 results)

  • [Journal Article] Synthesis of 6-F-ergosterol and its influence on membrane-permeabilization of amphotericin B and amphidinol 3.2011

    • Author(s)
      Kasai, Y., Matsumori, N., Ueno, H., Nonomura, K., Yano, S. Murata, M., Oishi, T.
    • Journal Title

      Org.Biomol.Chem. 9

      Pages: 1437-1442

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Conformations of spermine in ATP complex : The structural basis for weak bimolecular interactions of major cellular electrolytes.2011

    • Author(s)
      Maruyoshi, M., Yamaguchi, T., Demura, T., Matsumori, N., Oishi, T., Murata, M.
    • Journal Title

      Chem.Eur.J. 17

      Pages: 4788-4795

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of 6-F-ergosterol and its influence on membrane-permeabilization of amphotericin B and amphidinol 3.2011

    • Author(s)
      Kasai, Y., Matsumori, N., Ueno, H., Nonomura, K., Yano, S., Murata, M., Oishi, T.
    • Journal Title

      Org.Biomol.Chem.

      Volume: 9 Pages: 1437-1442

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] effect on interaction between amphidinol 3 and liposomal membrane as evidenced by surface plasmon resonance.2010

    • Author(s)
      Swasono, R., Mouri, R., Morsy, N., Matsumori, N., Oishi, T., Murata, M.Sterol
    • Journal Title

      Bioorg.Med.Chem.Lett. 20

      Pages: 2215-2218

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of Rap1A as yessotoxin binding target from blood cell membranes.2010

    • Author(s)
      Ujihara, S., Oishi, T., Mouri, R., Tamate, R., Konoki, K., Matsumori, N., Murata, M., Oshima, Y., Sugiyama, N., Tomita, M., Ishihama, Y.
    • Journal Title

      Bioorg.Med.Chem.Lett. 20

      Pages: 6443-6446

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sterol effect on interaction between amphidinol 3 and liposomal membrane as evidenced by surface plasmon resonance.2010

    • Author(s)
      Swasono, R., Mouri, R., Morsy, N., Matsumori, N., Oishi, T., Murata, M.
    • Journal Title

      Bioorg.Med.Chem.Lett.

      Volume: 20 Pages: 2215-2218

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of RaplA as yessotoxin binding target from blood cell membranes.2010

    • Author(s)
      Ujihara, S., Oishi, T., Mouri, R., Tamate, R., Konoki, K., Matsumori, N., Murata, M., Oshima, Y., Sugiyama, N., Tomita, M., Ishihama, Y.
    • Journal Title

      Bioorg.Med.Chem.Lett.

      Volume: 20 Pages: 6443-6446

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Conformational change of spermidine upon interacting with ATP in aqueous solution.2009

    • Author(s)
      Maruyoshi, K., Nonaka, K., Sagane, T., Demura, T., Yamaguchi, T., Matsumori, N., Oishi, T., Murata, M
    • Journal Title

      Chem.Eur.J. 15

      Pages: 1618-1626

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] interaction between amphotericin B and ergosterol in lipid bilayers as revealed by 2H2009

    • Author(s)
      Matsumori, N., Tahara, K., Yamamoto, H., Morooka, A., Doi, M., Oishi, T., Murata, M.Direct
    • Journal Title

      NMR.J.Am.Chem.Soc. 131

      Pages: 11855-11860

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Surface resonance-based detection of ladder-shaped polyether by competitive binding method.2009

    • Author(s)
      Mouri, R., Oishi, T., Torikai, K., Ujihara, S., Matsumori, N., Murata, M., Oshima, Y.
    • Journal Title

      Bioorg.Med.Chem.Lett. 19

      Pages: 2824-2828

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Amphotericin B-induced ion flux is markedly attenuated in phosphatidylglycerol membrane as evidenced by a newly devised fluorometric method.2009

    • Author(s)
      Takano, T., Konoki, K., Matsumori, N., Murata, M.
    • Journal Title

      Bioorg.Med.Chem. 17

      Pages: 6301-6304

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Direct interaction between amphotericin B and ergosterol in lipid bilayers as revealed by ^2H NMR.2009

    • Author(s)
      Matsumori, N., Tahara, K., Yamamoto, H., Morooka, A., Doi, M., Oishi, T.Murata, M.
    • Journal Title

      J.Am.Chem.Soc. 131

      Pages: 11855-11860

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ion channel complex of antibiotics as viewed by NMR.2009

    • Author(s)
      Murata, M., Kasai, Y., Umegawa, Y., Matsushita, N., Tsuchikawa, H., Matsumori, M.Oishi, T.
    • Journal Title

      Pure Appl.Chem. 81

      Pages: 1123-1129

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Amphotericin B-induced in flux is markedly attenuated in phosphatidylglycerol membrane as evidenced by a newly devised flurometric method.2009

    • Author(s)
      Takano, T., Konoki, K., Matsumori, N., Murata, M.
    • Journal Title

      Bioorg.Med.Chem. 17

      Pages: 6301-6304

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of 25-^<13>C-amphotericin B methyl ester : a molecular probe for solid-state NMR measurements.2009

    • Author(s)
      Matsushita, N., Matsuo, Y., Tsuchikawa, H.Matsumori, N., Murata, M., Oishi, T.
    • Journal Title

      Chem.Lett. 38

      Pages: 114-115

    • NAID

      10025118860

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Conformational change of spermidine upon interacting with adenosine triphosphate in aqueous solution.2009

    • Author(s)
      Marayoshi, K., Nonaka, K., Sagane, T., Demura, T., Yamaguchi, T., Matsumori, N., Oishi, T., Murata, M.
    • Journal Title

      Chem. Eur. J. 15

      Pages: 1618-1626

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of 25-^<13> C-amphotericin B methyl ester : a molecular probe for solid-state NMR measurements.2009

    • Author(s)
      Matsushita, N., Matsuo, Y., Tsuchikawa, H. Matsumori, N., Murata, M., Oishi, T.
    • Journal Title

      Chem. Lett. 38

      Pages: 114-115

    • NAID

      10025118860

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Design, synthesis, and biological evaluation of fluorinated analogs of salicylihalamide.2009

    • Author(s)
      Sugimoto, Y., Konoki, K., Murata, M., Matsushita, M., Kanazawa, H., Oishi, T.
    • Journal Title

      J. Med. Chem. 52

      Pages: 798-806

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Self-assembly of amphotericin B is probably surrounded by ergosterol; bimolecular interactions as evidenced by solid stata NMR and CD spectra.2008

    • Author(s)
      Kasai, Y., Matsumori, N., Umegawa, Y., Matsuoka, S., Ueno, H., Ikeuchi, H., Oishi, T., Murata, M.
    • Journal Title

      Chem.Eur.J. 14

      Pages: 1178-1185

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of lipid constituents on membrane-permeabilizing activity of amphidinols.2008

    • Author(s)
      Morsy, N., Houdai, T., Konoki, K., Matsumori, N., Oishi, T., Murata, M
    • Journal Title

      Bioorg.Med.Chem. 16

      Pages: 3084-3090

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Roles of integral protein in membrane permeabilization by amphidinols.2008

    • Author(s)
      Morsy, N., Konoki, K., Houdai, T., Matsumori, N.Oishi, T., Murata, M., Aimoto, S.
    • Journal Title

      Biochim.Biophys.Acta. 1778

      Pages: 1453-1459

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Orientation of fluorinated cholesterol in lipid bilayers analyzed by 19F tensor calculation and solid-state NMR.2008

    • Author(s)
      Matsumori, N., Kasai, Y., Oishi, T., Murata, M., Nomura, K.
    • Journal Title

      J.Am.Chem.Soc. 130

      Pages: 4757-4766

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Complex formation of amphotericin B in sterol-containing membrane as evidenced by surface plasmon resonance.2008

    • Author(s)
      Mouri, R., Konoki, K., Matsumori, N., Oishi, T., Murata, M.
    • Journal Title

      Biochemistry 47

      Pages: 7807-7815

    • Related Report
      2010 Final Research Report 2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Design and synthesis of ladder-shaped tetracyclic, heptacyclic, and decacyclic ethers and evaluation of the interaction with transmembrane proteins.2008

    • Author(s)
      Torikai, K., Oishi, T., Ujihara, S., Matsumori,N., Koniki, K.Murata, M., Aimoto, S.
    • Journal Title

      J.Am.Chem.Soc. 30

      Pages: 10217-10226

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Structure of membrane-bound amphidinol 3 in isotropic small bicelles.2008

    • Author(s)
      Houdai, T., Matsumori, N., Murata, M.
    • Journal Title

      Org.Lett. 10

      Pages: 4191-4194

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interaction of ladder-shaped polyethers with transmembrane α-helix of glycophorin A as evidenced by saturation transfer difference NMR and surface plasmon resonace.2008

    • Author(s)
      Ujihara, S., Oishi, T., Torikai, K., Konoki, K., Matsumori, N., Murata, M., Oshima, Y., Aimoto, S.
    • Journal Title

      Bioorg.Med.Chem.Lett. 18

      Pages: 6115-6118

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ergosterol increases intermolecular distance of amphotericin B in membrane-bound assembly as evidenced by solid-state NMR.2008

    • Author(s)
      Umegawa, Y., Matsumori, N., Oishi, T.,Murata, M.
    • Journal Title

      Biochemistry 47

      Pages: 13463-13469

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Self-assembly of amphotericin B is probably surrounded by ergosterol ; bimolecular interactions as evidenced by solid state NMR and CD spectra2008

    • Author(s)
      Kasai Y., Matsumori N., Umegawa Y., Matsuoka S., Ueno H., Ikeuchi H., Oishi T. and Murata M
    • Journal Title

      Chem. Eur. J. 14

      Pages: 1178-1185

    • Related Report
      2008 Self-evaluation Report
  • [Journal Article] Orientation of fluorinated cholesterol in lipid bilayers analyzed by ^<19>F tensor calculation and solid-state NMR2008

    • Author(s)
      Matsumori N., Kasai Y., Oishi T., Murata M. and Nomura K.
    • Journal Title

      J. Am. Chem. Soc. 130

      Pages: 4757-4766

    • Related Report
      2008 Self-evaluation Report
  • [Journal Article] Complex formation of amphotericin B in sterol-containing membrane as evidenced by surface plasmon resonance2008

    • Author(s)
      Mouri R., Konoki K., Matsumori N., Oishi T. and Murata M.
    • Journal Title

      Biochemistry 47

      Pages: 7807-7815

    • Related Report
      2008 Self-evaluation Report
  • [Journal Article] Ergosterol increases intermolecular distance of amphotericin B in membrane-bound assembly as evidenced by solid-state NMR2008

    • Author(s)
      Umegawa Y., Matsumori N., Oishi T. and Murata M.
    • Journal Title

      Biochemistry 47

      Pages: 13463-13469

    • Related Report
      2008 Self-evaluation Report
  • [Journal Article] Orientation of fluorinated cholesterol in lipid bilayers analyzed by ^<19>F tensor calculation and solid-state NMR.2008

    • Author(s)
      Matsumori, N., Kasai, Y., Oishi, T., Murata, M., Nomura, K.
    • Journal Title

      J. Am. Chem. Soc. 130

      Pages: 4757-4766

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Design and synthesis of ladder-shaped tetracyclic, heptacyclic, and decacyclic ethers and evaluation of the interaction with transmembrane proteins.2008

    • Author(s)
      Torikai, K., Oishi, T., Ujihara, S., Matsumori, N., Koniki, K. Murata, M., Aimoto, s.
    • Journal Title

      J. Am. Chem. Soc. 30

      Pages: 10217-10226

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Convergent synthesis and biological activity of the WXYZA'B'C' ring system of maitotoxin.2008

    • Author(s)
      Oishi, T., Hasegawa, F., Torikai, K., Konoki, K., Matsumori, N., Murata, M.
    • Journal Title

      Org. Lett. 10

      Pages: 3599-3602

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure of membrane-bound amphidinol 3 in isotropic small bicelles.2008

    • Author(s)
      Houdai, T., Matsumori, N., Murata, M.
    • Journal Title

      Org. Lett. 10

      Pages: 4191-4194

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Accurate measurement of vicinal carbon-hydrogen coupling constants via ammonium nitrogen based on HMBC experiments.2008

    • Author(s)
      Yamaguchi, T., Maruyoshi, K., Matsumori, N., Murata, M.
    • Journal Title

      Chem. Lett. 37

      Pages: 1172-1173

    • NAID

      10024397270

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Convergent synthesis of the A-J ring system of yessotoxin.2008

    • Author(s)
      Torikai, K., Watanabe, K., Minato, H., Imaizumi, T., Murata, M., Oishi, T.
    • Journal Title

      Synlett.

      Pages: 2368-2372

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ascidian sperm activating and attracting factor : importance of sulfate groups for the activities and implication of its putative receptor.2008

    • Author(s)
      Yoshida, M., Shiba, K., Yoshida, K., Tsuchikawa, H., Ootou, O., Oishi, T., Murata, M.
    • Journal Title

      FEBS Lett. 582

      Pages: 3429-3433

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Valosin-containing protein (VCP)/p97 interacts with SAAF in the ascidian egg and modulates sperm-attracting activity.2008

    • Author(s)
      Kondoh, E., Konno, A., Inaba, K., Oishi, T., Murata, M., Yoshida, M.
    • Journal Title

      Develop. Grow. Differ. 50

      Pages: 665-673

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interaction of ladder-shaped polyethers with transmembrane α-helix of glycophorin A as evidenced by saturation transfer difference NMR and surface plasmon resonace.2008

    • Author(s)
      Ujihara, S., Oishi, T., Torikai, K., Konoki, K., Matsumori, N., Murata, M., Oshima, Y, Aimoto, S.
    • Journal Title

      Bioorg. Med. Chem. Lett. 18

      Pages: 6115-6118

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Combinatorial synthesis of 1,5-polyol system based on cross metathesis : Structure revision of amphidinol 3.2008

    • Author(s)
      Oishi, T., Kanemoto, M., Swasono, R., Matsumori, N., Murata, M.
    • Journal Title

      Org. Lett. 10

      Pages: 5203-5206

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ergosterol increases intermolecular distance of amphotericin B in membrane-bound assembly as evidenced by solid-state NMR.2008

    • Author(s)
      Umegawa, Y., Matsumori, N., Oishi, T., Murata, M.
    • Journal Title

      Biochemistry 47

      Pages: 13463-13469

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Self-assembly of amphotericin B is probably surrounded by ergosterol; bimolecular interactions as evidenced by solid stata NMR and CD spectra.2008

    • Author(s)
      Kasai, Y., Matsumori, N., Umegawa, Y., Matsuoka, S., Ueno, H., Ikeuchi, H., Oishi, T. and Murata, M.
    • Journal Title

      Chem. Eur. J. 14

      Pages: 1178-1185

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of integral protein in membrane permeabilization by amphidinols.2008

    • Author(s)
      Morsy, N., Konoki, K., Houdai, T., Matsumori, N. Oishi, T., Murata, M. and Aimoto, S.
    • Journal Title

      Biochim. Biophys. Acta. (印刷中)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of lipid constituents on membrane-permeabilizing activity of amphidinols.2008

    • Author(s)
      Morsy, N., Houdai, T., Konoki, K., Matsumori, N., Oishi, T. Murata, M.
    • Journal Title

      Bioorg. Med. Chem. (印刷中)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural Features of Dinoflagellate Toxins Underlying Biological Activity as Viewed by NMR.2008

    • Author(s)
      Murata, M., Matsumori, N., Konoki, K. and Oishi, T.
    • Journal Title

      Bull. Chem. Soc. Jpn. (印刷中)

    • NAID

      10021073872

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Conformation and position of membrane-bound amphotericin B deduced from NMR in SDS micelles.2007

    • Author(s)
      Matsumori, N., Houdai, T., Murata, M.
    • Journal Title

      J.Org.Chem. 72

      Pages: 700-704

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Conformation and location of membrane-bound salinomycin-sodium complex deduced from NMR in isotropic bicelles.2007

    • Author(s)
      Matsumori, N.Morooka, A., Murata, M.
    • Journal Title

      J.Am.Chem.Soc. 129

      Pages: 14889-14995

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Conformation and position of membrane-bound amphotericin B deduced from NMR in SDS micelles2007

    • Author(s)
      Matsumori N., Houdai T. and Murata M.
    • Journal Title

      J. Org. Chem. 72

      Pages: 700-704

    • Related Report
      2008 Self-evaluation Report
  • [Journal Article] Conformation and position of membrane-bound amphotericin B deduced from NMR in SDS micelles.2007

    • Author(s)
      Matsumori, N., Houdai, T. and Murata, M.
    • Journal Title

      J. Org. Chem. 72

      Pages: 700-704

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Conformation and Location of Membrane-Bound Salinomycin-Sodium Complex Deduced from NMR in Isotropic Bicelles.2007

    • Author(s)
      Matsumori, N. Morooka, A., and Murata, M.
    • Journal Title

      J. Am. Chem. Soc. 129

      Pages: 14889-14995

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Conformation and position of membrane-bound amphotericin B deduced from NMR in SDS micelles.2007

    • Author(s)
      Matsumori, N., Houdai, T., Murata, M
    • Journal Title

      J.Org.Chem. 72

      Pages: 700-706

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Amphotericin B covalent dimers with carbony-amino linkage : a new probe for investigating ion channel assemblies.2007

    • Author(s)
      Umegawa, Y., Matsumori, N., Oishi, T, Murata, M.
    • Journal Title

      Tetrahedron Lett. 48(in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Detailed description on Conformation and Location of Membrane-bound Erythromycin A using Small Bicelle.2006

    • Author(s)
      Matsumori, N., Morooka, A., Murata, M.
    • Journal Title

      J.Med.Chem. 49

      Pages: 3501-3508

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Membrane interaction of amphotericin B as single-Length assembly examined by solid state NMR for uniformly ^<13>C-enriched Agent.2006

    • Author(s)
      Matsuoka, S., Ikeuchi, H., Umegawa, Y., Matsumori, N., Murata, M.
    • Journal Title

      Bioorg.Med.Chem. 14

      Pages: 6608-6614

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of 28-19F-amphotericn B methyl ester.2006

    • Author(s)
      Tsuchikawa, H., Matsushita, N., Matsumori, N., Murata, M., Oishi, T.
    • Journal Title

      Tetrahedron Lett. 47

      Pages: 6187-6191

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Membrane interaction of amphotericin B as single-Length assembly examined by solid state NMR for uniformly ^<13>C-enriched Agent.2006

    • Author(s)
      Matsuoka, S., Ikeuchi, H., Umegawa, Y., Matsumori, N., Murata M.
    • Journal Title

      Bioorg.Med.Chem. 14

      Pages: 6608-6614

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Structures of new amphidinols with truncated polyhydroxyl chain and their membrane permeabilizing activities.2006

    • Author(s)
      Morsy, N., Houdai, T., Matsuoka, S., Matsumori, N., Adachi, S., Oishi, T., Murata, M., Iwashita, T., Fujita.T
    • Journal Title

      Bioorg.Med.Chem. 14

      Pages: 6548-6554

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Large molecular assembly of amphotericin B formed in ergosterol-containing membrane evidenced by solid-state NMR of intramolecular bridged derivative.2006

    • Author(s)
      Matsumori, N., Sawada, Y., Murata, M
    • Journal Title

      J.Am.Chem.Soc. 128

      Pages: 11977-11984

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Synthesis of 28-^<19>F-amphotericn B methyl ester.2006

    • Author(s)
      Tsuchikawa, H., Matsushita, N., Matsumori, N., Murata, M., Oishi, T
    • Journal Title

      Tetrahedron Lett. 47

      Pages: 6187-6191

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Conformations of spermine in ATP complex : The structural basis for weak bimolecular interactions of major cellular electrolytes.

    • Author(s)
      Maruyoshi, M., Yamaguchi, T., Demura, T., Matsumori, N., Oishi T., Murata, M.
    • Journal Title

      Chem.Eur.J.

      Volume: (in press 未定)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] SSNMR investigations of organic molecules in lipid bilayers : Application to amphotericin B and lipid rafts2010

    • Author(s)
      Nobuaki Matsumori
    • Organizer
      The 2010 International Chemical Congress of Pacific Basin Societies.
    • Place of Presentation
      米国ハワイ州、Honolulu
    • Year and Date
      2010-12-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Ion Channel Assembly of Small Molecules in Membrane2009

    • Author(s)
      Michio Murata
    • Organizer
      13^<th> Asian Chemical Congress
    • Place of Presentation
      Shanghai(CHINA)
    • Year and Date
      2009-09-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] Ion channel complex of antibiotics as viewed by NMR2008

    • Author(s)
      Michio Murata
    • Organizer
      PAC ICOB-6, SCNP-26
    • Place of Presentation
      Charlottetown, CANADA(招待講演)
    • Year and Date
      2008-07-17
    • Related Report
      2010 Final Research Report
  • [Presentation] Funcitonal Membrane Complexes2008

    • Author(s)
      Steroids as a Key Player in Assembling Michio Murata
    • Organizer
      Nakanishi Symposium
    • Place of Presentation
      立教大学(招待講演)
    • Year and Date
      2008-03-28
    • Related Report
      2010 Final Research Report
  • [Presentation] Molecular Assemblies in Biomembranes as Viewed by Solid State NMR2008

    • Author(s)
      Michio Murata
    • Organizer
      Naito Conference Chemical Biology(シャトレーゼガトーキングダム)
    • Place of Presentation
      札幌(招待講演)
    • Related Report
      2010 Final Research Report
  • [Presentation] Synthesis of fluorine labeled natural products for solid-state NMR measurements2008

    • Author(s)
      Tohru Oishi
    • Organizer
      236th ACS National Meeting
    • Place of Presentation
      Philadelphia, USA(招待講演)
    • Related Report
      2010 Final Research Report
  • [Presentation] Natural products forming functional assemblies in biomembrane2008

    • Author(s)
      Michio Murata
    • Organizer
      Mona Symposium
    • Place of Presentation
      Kingston, JAMAICA(招待講演)
    • Related Report
      2010 Final Research Report
  • [Presentation] Synthetic studies of yessotoxin2007

    • Author(s)
      Tohru Oishi
    • Organizer
      International Symposium on Catalysts and Fine Chemicals
    • Place of Presentation
      Nanyang Tech.Univ.Singapore(招待講演)
    • Year and Date
      2007-12-17
    • Related Report
      2010 Final Research Report
  • [Presentation] Yessotoxin and synthetic polyether models-Interactions with peptides in membrane2007

    • Author(s)
      Michio Murata
    • Organizer
      Vth European Conference on Marine Natura Products
    • Place of Presentation
      Ischia, ITALY(招待講演)
    • Related Report
      2010 Final Research Report
  • [Presentation] Marine cyclic polyethers-their interaction with membrane proteins2007

    • Author(s)
      Michio Murata
    • Organizer
      日米セミナー海洋天然物
    • Place of Presentation
      Salt Lake City, USA(招待講演)
    • Related Report
      2010 Final Research Report
  • [Presentation] Synthetic studies of natural and artificial ladder-shaped polyethers for exploring biological functions2006

    • Author(s)
      Tohru Oishi
    • Organizer
      Sendai Postsymposium of ICOB-5, ISCNP-25
    • Place of Presentation
      仙台国際センター(招待講演)
    • Year and Date
      2006-07-30
    • Related Report
      2010 Final Research Report
  • [Book] 広がる核磁気共鳴NMRの世界2011

    • Author(s)
      村田道雄(分担執筆)
    • Total Pages
      4
    • Publisher
      コロナ社
    • Related Report
      2010 Annual Research Report
  • [Book] In "Progress in Molecular and Subcellular Biology"(N., Fusetani, A. S. Clare, Eds., Springer-Verlag, Berlin Heidelberg)2006

    • Author(s)
      Murata, M., Oishi, T. and Yoshida, M.
    • Publisher
      State-of-Art Methodology of Marine Natural Products Chemistry : Structure Determination with Extremely Small Sample Amounts
    • Related Report
      2008 Self-evaluation Report
  • [Book] Progress in Molecular and Subcellular Biology2006

    • Author(s)
      Murata, M., Oishi, T., Yoshida, M.
    • Total Pages
      18
    • Publisher
      Springer-Verlag
    • Related Report
      2006 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.chem.sci.osaka-u.ac.jp/lab/murata/

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.chem.sci.osaka-u.ac.jp/lab/murata/research/index.htm

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.chem.sci.osaka-u.ac.jp/lab/murata/research/index.htm

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.ch.wani.osaka-u.ac.jp/lab/murata

    • Related Report
      2008 Self-evaluation Report
  • [Remarks]

    • URL

      http://www.chem.sci.osaka-u.ac.jp/lab/murata/research/index.htm

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.chem.sci.osaka-u.ac.jp/lab/murata/research/index.htm

    • Related Report
      2007 Annual Research Report

URL: 

Published: 2006-04-01   Modified: 2016-04-21  

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