Novel Mechanisms of the Regulation of Reproduction by Novel Brain Hormones

• Project/Area Number: 18107002
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Morphology/Structure
• Research Institution: Waseda University
• Principal Investigator: TSUTSUI Kazuyoshi Waseda University, 教育・総合科学学術院, 教授 (20163842)
• Co-Investigator(Kenkyū-buntansha): MINAKATA Hiroyuki サントリー生物有機科学研究所, 部長研究員 (90150143) ; UKENA Kazuyoshi 広島大学, 大学院・総合科学研究科, 准教授 (10304370) ; TANAKA Shigeyasu 静岡大学, 創造科学技術大学院, 教授 (90146233)
• Project Period (FY): 2006 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥107,770,000 (Direct Cost: ¥82,900,000、Indirect Cost: ¥24,870,000); Fiscal Year 2010: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000); Fiscal Year 2009: ¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000); Fiscal Year 2008: ¥22,100,000 (Direct Cost: ¥17,000,000、Indirect Cost: ¥5,100,000); Fiscal Year 2007: ¥22,100,000 (Direct Cost: ¥17,000,000、Indirect Cost: ¥5,100,000); Fiscal Year 2006: ¥29,250,000 (Direct Cost: ¥22,500,000、Indirect Cost: ¥6,750,000)
• Keywords: 視床下部ホルモン / 脳下垂体ホルモン / 発現制御 / シグナル伝達 / 生殖 / 分子進化

Research Abstract

We discovered a novel avian hypothalamic neuropeptide inhibiting gonadotropin release, named gonadotropin-inhibitory hormone (GnIH). We demonstrated that GnIH acts on gonadotropes and GnRH neurons via GPR147 to inhibit gonadal development and maintenance by decreasing gonadotropin release and synthesis. We further demonstrated that GnIH has an evolutionarily conserved role in controlling reproduction across vertebrate species.

Research Products

• [Journal Article] Light-dependent and circadian clock-regulated activation of SREBP, XBP1 and HSF pathways. (2011)
  • Author(s): M.Hatori(筆頭著者), K.Tsutsui, et al.
  • Journal Title: Proc.Natl.Acad.Sci.USA 108巻 Pages: 4868-4869
  • Peer Reviewed
• [Journal Article] Identification, localization and expression of LPXRFamide peptides, and melatonin-dependent induction of their precursor mRNA in the newt brain. (2011)
  • Author(s): V.S.Chowdhury, T.Ubuka, T.Osugi, T.Shimura, K.Tsutsui
  • Journal Title: J.Endocrinol. 209巻 Pages: 1-12
  • Peer Reviewed
• [Journal Article] Effects of gonadotropin-inhibitory hormone on folliculogenesis and steroidogenesis of cyclic mice. (2011)
  • Author(s): P.Singh, A.Krishna, K.Tsutsui
  • Journal Title: Fertil.Steril. 95巻 Pages: 1397-1404
  • Peer Reviewed
• [Journal Article] Review : Molecular evolution and functional characterization of the orexigenic peptide 26RFa and its receptor in vertebrates : Discovery and comparative aspects. (2011)
  • Author(s): K.Ukena, H.Vaudry, J.Leprince, K.Tsutsui
  • Journal Title: Cell Tissue Res. 343巻 Pages: 475-481
  • Peer Reviewed
• [Journal Article] Photoperiod and reproductive condition are associated with changes in RFamide-related peptide (RFRP) expression in Syrian hamsters (Mesocricetus auratus). (2010)
  • Author(s): A.O.Mason(筆頭著者), K.Tsutsui, et al.
  • Journal Title: J.Biol.Rhythm. 25巻 Pages: 176-185
  • Peer Reviewed
• [Journal Article] Identification, localization and function of a novel avian hypothalamic neuropeptide, 26RFa, and its cognate receptor, GPR103. (2010)
  • Author(s): K.Ukena(筆頭著者), K.Tsutsui, et al.
  • Journal Title: Endocrinology 151巻 Pages: 2255-2264
  • Peer Reviewed
• [Journal Article] Prolactin increases the synthesis of 7α-hydroxypregnenolone, a key factor for induction of locomotor activity, in breeding male newts. (2010)
  • Author(s): S.Haraguchi(筆頭著者), K.Tsutsui, et al.
  • Journal Title: Endocrinology 151巻 Pages: 2211-2222
  • Peer Reviewed
• [Journal Article] Salt-sensitive hypertension in circadian clock-deficient Cry-null mice involves dysregulated adrenal Hsd3b6. (2010)
  • Author(s): M.Doi(筆頭著者), K.Tsutsui, et al.
  • Journal Title: Nature Medicine 16巻 Pages: 67-74
  • Peer Reviewed
• [Journal Article] RFamide-related peptide (RFRP) and mRNA expression in mammalian testis : Association with the spermatogenic cycle. (2010)
  • Author(s): S.Zhao(筆頭著者), K.Tsutsui, et al.
  • Journal Title: Endocrinology 151巻 Pages: 617-627
  • Peer Reviewed
• [Journal Article] Temporal phase relation of circadian neural oscillations alters RFamide-related peptide-3 (RFRP-3), a mammalian gonadotropininhibitory hormone (GnIH) homolog, and testicular function in the mouse (Mumusculus). (2010)
  • Author(s): S.Sethi, K.Tsutsui, C.M.Chaturvedi
  • Journal Title: Neuroendocrinology 91巻 Pages: 189-199
  • Peer Reviewed
• [Journal Article] Review : 7α-Hydroxypregnenolone, a new key regulator of locomotor activity of vertebrates : Identification, mode of action and functional significance. (2010)
  • Author(s): K.Tsutsui(筆頭著者), S.Haraguchi, et al.
  • Journal Title: Front. Endocrinol. 1巻
  • Peer Reviewed
• [Journal Article] Review : Recent studies of gonadotropininhibitory hormone (GnIH) in the mammalian hypothalamus, pituitary and gonads. (2010)
  • Author(s): G.E.Bentley, K.Tsutsui, L.J.Kriegsfeld
  • Journal Title: Brain Res. 1364巻 Pages: 62-71
  • Peer Reviewed
• [Journal Article] Review : Discovery and evolutionary history of GnIH and kisspeptin : New key neuropeptides controlling reproduction. (2010)
  • Author(s): K.Tsutsui(筆頭著者), G.E.Bentley, et al.
  • Journal Title: J.Neuroendocrinol. 22巻 Pages: 716-727
  • Peer Reviewed
• [Journal Article] Review : The roles of RFamide-related peptide-3 (RFRP-3) in mammalian reproductive function and behaviour. (2010)
  • Author(s): L.J.Kriegsfeld(筆頭著者), K.Tsutsui, et al.
  • Journal Title: J.Neuroendocrinol. 22巻 Pages: 692-700
  • Peer Reviewed
• [Journal Article] Review : Gonadotropin-inhibitory hormone (GnIH) and its control of central and peripheral reproductive function. (2010)
  • Author(s): K.Tsutsui(筆頭著者), G.E.Bentley, et al.
  • Journal Title: Front.Neuroendocrinol. 31巻 Pages: 284-295
  • Peer Reviewed
• [Journal Article] Review : Phylogenetic aspects of gonadotropin-inhibitory hormone (GnIH) and its homologs in vertebrates. (2010)
  • Author(s): 筒井和義
  • Journal Title: Ann.N.Y.Acad.Sci. 1200巻 Pages: 75-84
  • Peer Reviewed
• [Journal Article] 総説:性周期とニューロペプチド:GnIH (2010)
  • Author(s): 筒井和義・産賀崇由
  • Journal Title: 特集「ニューロペプチド」Hormone Frontier in Gynecologyメディカルレビュー社 第17巻 Pages: 25-29
• [Journal Article] Photoperiod and reproductive condition are associated with changes in RF amide-related peptide(RFRP)expression in Syrian hamsters(Mesocricetus auratus) (2010)
  • Author(s): A.O.Mason, et al.
  • Journal Title: J.Biol.Rhythm. (in press)
  • Peer Reviewed
• [Journal Article] Effects of gonadotropin-inhibitory hormone on folliculogenesis and steroidogenesis of cyclic mice (2010)
  • Author(s): P.Singh, K.Tsutsui
  • Journal Title: Fertil.Steril. (in press)
  • Peer Reviewed
• [Journal Article] Review : Phylogenetic aspects of gonadotropin-inhibitory hormone(GnIH)and its homologs in vertebrates (2010)
  • Author(s): 筒井和義
  • Journal Title: Ann.N.Y.Acad.Sci. (in press)
  • Peer Reviewed
• [Journal Article] 総説:性周期とニューロペプチド:GnIH特集「ニューロペプチド」Hormone Frontier in Gynecology (2010)
  • Author(s): 筒井和義・産賀崇由
  • Journal Title: メディカルレビュー社 第17巻(in press)
  • Peer Reviewed
• [Journal Article] Identification, localization and function of a novel avian hypothalamic neuropeptide, 26RFa, and its cognate receptor, GPR103 (2010)
  • Author(s): K.Ukena, et al.
  • Journal Title: Endocrinology (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Prolactin increases the synthesis of 7α-hydroxypregnenolone, a key factor for induction of locomotor activity, in breeding male newts (2010)
  • Author(s): S.Haraguchi, et al.
  • Journal Title: Endocrinology (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Identification of gonadotropin-inhibitory hormone in the zebra finch(Taeniopygia guttata) : peptide isolation, cDNA cloning and brain distribution (2010)
  • Author(s): Y.Tobari, et al.
  • Journal Title: Peptides (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Review : Gonadotropin-inhibitory hormone(GnIH)and its control of central and peripheral reproductive function (2010)
  • Author(s): 筒井和義, et al.
  • Journal Title: Front. Neuroendocrinol. (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Review : Identification of 7α-hydroxypregnenolone, novel bioactive amphibian neurosteroid stimulating locomotor activity, and its physiological roles in the regulation of locomotion (2010)
  • Author(s): 筒井和義, et al.
  • Journal Title: Gen.Comp.Endocrinol. (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Salt-sensitive hypertension in circadian clock-deficient Cry-null mice involves dysregulated adrenal Hsd3b6 (2010)
  • Author(s): M.Doi, et al.
  • Journal Title: Nature Medicine 16 Pages: 67-74
  • Peer Reviewed
• [Journal Article] RFamide-related peptide(RFRP)and mRNA expression in mammalian testis : Association with the spermatogenic cycle (2010)
  • Author(s): S.Zhao, et al.
  • Journal Title: Endocrinology 151 Pages: 617-627
  • Peer Reviewed
• [Journal Article] GnIHによるゴナドトロピン分泌制御 特集/生殖機能調節の新しい視点 産科と婦人科 (2010)
  • Author(s): 筒井和義
  • Journal Title: Obstet. Gynecol.; 診断と治療社 77 Pages: 252-258
  • Peer Reviewed
• [Journal Article] Melatonin stimulates the release of gonadotropin-inhibitory hormone by the avian hypothalamus (2010)
  • Author(s): V.S.Chowdhury, et al.
  • Journal Title: Endocrinology 151 Pages: 271-280
  • Peer Reviewed
• [Journal Article] Temporal phase relation of circadian neural oscillations alters RFamide-related peptide-3(RFRP-3), amammalian gonadotropin-inhibitory hormone(GnIH) (2010)
  • Author(s): S.Sethi, et al.
  • Journal Title: Neuroendocrinology 91 Pages: 189-199
  • Peer Reviewed
• [Journal Article] Melatonin stimulates the release of gonadotropininhibitory hormone by the avian hypothalamus. (2009)
  • Author(s): V.S.Chowdhury(筆頭著者), K.Tsutsui, et al.
  • Journal Title: Endocrinology Endocrine news 151巻 Vol. 34 No.12
  • Peer Reviewed
• [Journal Article] Identification of human gonadotropin-inhibitory hormone homologs, RFRP-1 and RFRP-3, and the cognate receptor, GPR147 in the human hypothalamic pituitary axis. (2009)
  • Author(s): T.Ubuka(筆頭著者), K.Tsutsui, et al.
  • Journal Title: PLoS ONE 4巻
  • Peer Reviewed
• [Journal Article] Gonadotropin-inhibitory hormone identification, cDNA cloning, and distribution in rhesus macaque brain. (2009)
  • Author(s): T.Ubuka(筆頭著者), K.Tsutsui, et al.
  • Journal Title: J.Comp.Neurol. 517巻 Pages: 841-855
  • Peer Reviewed
• [Journal Article] Molecular evolution of multiple forms of kisspeptins and GPR54 receptors in vertebrates. (2009)
  • Author(s): Y.R.Lee(筆頭著者), K.Tsutsui, et al.
  • Journal Title: Endocrinology 150巻 Pages: 2837-2846
  • Peer Reviewed
• [Journal Article] Review : Neurosteroid biosynthesis : enzymatic pathways and neuroendocrine regulation by neurotransmitters and neuropeptides. (2009)
  • Author(s): J.L.Do Rego(筆頭著者), K.Tsutsui, et al.
  • Journal Title: Front.Neuroendocrinol. 30巻 Pages: 259-301
  • Peer Reviewed
• [Journal Article] Review : A new key neurohormone controlling reproduction, gonadotropin-inhibitory hormone (GnIH) : Biosynthesis, mode of action and functional significance. (2009)
  • Author(s): 筒井和義
  • Journal Title: Prog.Neurobiol. 88巻 Pages: 76-88
  • Peer Reviewed
• [Journal Article] Review : Neurosteroid biosynthesis and action in the Purkinje cell. (2009)
  • Author(s): 筒井和義
  • Journal Title: J.Exp.Neurosci. 2巻 Pages: 1-12
  • Peer Reviewed
• [Journal Article] A new key neurohormone controlling reproduction, gonadotropin-inhibitory hormone (GnIH) in birds : discovery, progress and prospect (review). (2009)
  • Author(s): K.Tsutsui(筆頭著者), E.Saigoh, et al.
  • Journal Title: J.Neuroendocrinol. 21巻 Pages: 271-275
  • Peer Reviewed
• [Journal Article] GnIH : Amultifunctional neuropeptide (review). (2009)
  • Author(s): G.E.Bentley(筆頭著者), K.Tsutsui, et al.
  • Journal Title: J.Neuroendocrinol. 21巻 Pages: 276-281
  • Peer Reviewed
• [Journal Article] Octopus GnRH (oct-GnRH), a multifunctional peptide in the endocrine and nervous systems of the cephalopod (review). (2009)
  • Author(s): H.Minakata, S.Shigeno, N.Kano, S.Haraguchi, T.Osugi, K.Tsutsui
  • Journal Title: J.Neuroendocrinol. 21巻 Pages: 322-326
  • Peer Reviewed
• [Journal Article] Evolutionary origin and divergence of GnIH and its homologous peptides (review). (2009)
  • Author(s): K.Tsutsui, T.Osugi
  • Journal Title: Gen.Comp.Endocrinol. 161巻 Pages: 30-33
  • Peer Reviewed
• [Journal Article] メラトニンとGnIHの光周性「光周性の分子生物学」海老原・井澤編 (2009)
  • Author(s): 筒井和義
  • Journal Title: シュプリンガー Pages: 149-157
• [Journal Article] メラトニンに関する最近の話題:メラトニンとGnIH Annual Review糖尿病・代謝・内分泌 2009 (2009)
  • Author(s): 筒井和義
  • Journal Title: 中外医学社, V.生殖医学 Pages: 190-195
• [Journal Article] Review : Proximate and ultimate mechanisms driving circadian control of neuroendocrine function : Lessons from the young and old (2009)
  • Author(s): W.P.Williams III, et al.
  • Journal Title: Integr.Comp.Biol. (in press)
  • Peer Reviewed
• [Journal Article] Identification of human gonadotropin-inhibitory hormone homologs, RFRP-1 and RFRP-3, and the cognate receptor, GPR147 in the human hypothalamic pituitary axis (2009)
  • Author(s): T.Ubuka, et al.
  • Journal Title: PLoS ONE 4
  • Peer Reviewed
• [Journal Article] Gonadotropin-inhibitory hormone identification. cDNA cloning, and distribution in rhesus macaque brain (2009)
  • Author(s): T.Ubuka, et al.
  • Journal Title: J.Comp.Neurol. 517 Pages: 841-855
  • Peer Reviewed
• [Journal Article] Molecular evolution of multiple forms of kisspeptins and GPR54 receptors in vertebrates (2009)
  • Author(s): Y.R.Lee, et al.
  • Journal Title: Endocrinology 150 Pages: 2837-2846
  • Peer Reviewed
• [Journal Article] Diurnal changes in the synthesis of 7α-hydroxypregnenolone stimulating locomotor activity in newts (2009)
  • Author(s): T.Koyama, et al.
  • Journal Title: Ann.N.Y.Acad.Sci. 1163 Pages: 444-447
  • Peer Reviewed
• [Journal Article] Seasonal changes in the synthesis of 7α-hydroxypregnenolone stimulating locomotor activity in newts (2009)
  • Author(s): S.Haraguchi, et al.
  • Journal Title: Ann.N.Y.Acad.Sci. 1163 Pages: 410-413
  • Peer Reviewed
• [Journal Article] Review : Neurosteroid biosynthesis : enzymatic pathways and neuroendocrine regulation by neurotransmitters and neuropeptides (2009)
  • Author(s): J.L.Do Rego, et al.
  • Journal Title: Front.Neuroendocrinol. 30 Pages: 259-301
  • Peer Reviewed
• [Journal Article] Review : Discovery of a novel avian neurosteroid, 7α-hydroxypregnenoIone, and its role in the regulation of the diurnal rhythm of locomotor activity in Japanese quail (2009)
  • Author(s): 筒井和義, et al.
  • Journal Title: Gen.Comp.Endocrinol. 163 Pages: 117-122
  • Peer Reviewed
• [Journal Article] Review : A new key neurohormone controlling reproduction, gonadotropin-inhibitory hormone(GnIH) : Biosynthesis, mode of action and functional significance (2009)
  • Author(s): 筒井和義
  • Journal Title: Prog.Neurobiol. 88 Pages: 76-88
  • Peer Reviewed
• [Journal Article] Review : Neurosteroid biosynthesis and action in the Purkinje cell (2009)
  • Author(s): 筒井和義
  • Journal Title: J.Exp.Neurosci. 2 Pages: 1-12
  • Peer Reviewed
• [Journal Article] A new key neurohormone controlling reproduction, gonadotropin-inhibitory hormone(GnIH)in birds : discovery, progress and prospect(review) (2009)
  • Author(s): 筒井和義, et al.
  • Journal Title: J.Neuroendocrinol. 21 Pages: 271-275
  • Peer Reviewed
• [Journal Article] GnIH : A Multifunctional Neuropeptide(review) (2009)
  • Author(s): G.E.Bentley, et al.
  • Journal Title: J.Neuroendocrinol 21 Pages: 276-281
  • Peer Reviewed
• [Journal Article] Octopus GnRH(oct-GnRH), a multifunctional peptide in the endocrine and nervous systems of the cephalopod(review) (2009)
  • Author(s): H.Minakata, et al.
  • Journal Title: J.Neuroendocrinol. 21 Pages: 322-326
  • Peer Reviewed
• [Journal Article] Evolutionary origin and divergence of GnIH and its homologous peptides(review) (2009)
  • Author(s): 筒井和義, T.Osugi
  • Journal Title: Gen.Comp.Endocrinol. 161 Pages: 30-33
  • Peer Reviewed
• [Journal Article] Identification, biosynthesis and function of 7α-hydroxypregnenolone, a new key neurosteroid controlling locomotor activity, in non-mammals(review) (2009)
  • Author(s): 筒井和義, et al.
  • Journal Title: Ann.N.Y.Acad.Sci. 1163 Pages: 308-315
  • Peer Reviewed
• [Journal Article] Hormone-mediated reproductive behavior in the red-bellied newt(review) (2009)
  • Author(s): S.Kikuyama, et al.
  • Journal Title: Ann.N.Y.Acad.Sci. 1163 Pages: 179-186
  • Peer Reviewed
• [Journal Article] Steroid biosynthesis within the frog brain : A model of neuroendocrine regulation(review) (2009)
  • Author(s): J.L.Do Rego, et al.
  • Journal Title: Ann.N.Y.Acad.Sci. 1163 Pages: 83-92
  • Peer Reviewed
• [Journal Article] メラトニンに関する最近の話題:メラトニンとGnIH Annual Review 糖尿病・代謝・内分泌2009 (2009)
  • Author(s): 筒井和義
  • Journal Title: 中外医学社V.生殖医学 Pages: 190-195
  • Peer Reviewed
• [Journal Article] Molecular evolution of multiple forms of kisspeptins and GPR54 receptors in vertebrates (2009)
  • Author(s): Y. R. Lee (筆頭), K. Tsutsui (最終), et.al. (著者13名)
  • Journal Title: Endocrinology (印刷中)
  • Peer Reviewed
• [Journal Article] Review : A new key neurohormone controlling reproduction, gonadotropin-inhibitory hormone (GnIH) : Biosynthesis, mode of action and functional significance (2009)
  • Author(s): K. Tsutsui (単独)
  • Journal Title: Prog. Neurobiol (印刷中)
  • Peer Reviewed
• [Journal Article] Molecular evolution of multiple forms of kisspeptins and GPR54 receptors in vertebrates. (2009)
  • Author(s): Y. R. Lee, et al.
  • Journal Title: Endocrinology Epub ahead of print
  • Peer Reviewed
• [Journal Article] Diurnal changes in the synthesis of 7aIpha-hydroxypregnenolone stimulating locomotor activity in newts (2009)
  • Author(s): T. Koyama, et al.
  • Journal Title: Ann. N. Y. Acad. Sci. (in press)
  • Peer Reviewed
• [Journal Article] Seasonal changes in the synthesis of 7aIpha-hydroxypregnenoIone stimulating Iocomotor activity in newtS. (2009)
  • Author(s): S. Haraguchi, et al.
  • Journal Title: Ann. N. Y. Aoad. Sci. (in press)
  • Peer Reviewed
• [Journal Article] Neurosteroid biosynthesis : enzymatic pathways and neuroendoorine regulation by neurotransmitters and n europeptides. (2009)
  • Author(s): J. L. Do Rego, et al.
  • Journal Title: Front. Neuroendocrinol. (in press)
  • Peer Reviewed
• [Journal Article] Review : Discovery of a novel avian neurosteroid, 7alpha-hydroxypregnenolone, and its role in the regulation of the diurnal rhythm of locomotor activity in Japanese quail. (2009)
  • Author(s): K. Tsutsui, et al.
  • Journal Title: Gen. Comp. Endocrinol. (in press)
  • Peer Reviewed
• [Journal Article] Review : Proximate and ultimate mechanisms driving circadian control of neuroendoorine function : Lessons from the young and old. (2009)
  • Author(s): W. P. Williams III, et al.
  • Journal Title: Integr. Comp. Biol. (in press)
  • Peer Reviewed
• [Journal Article] Review : Gonadotropin-inhibitory hormone(GnlH) and its homologous peptides in vertebrates : discovery, mode of action and functional significance. (2009)
  • Author(s): K. Tsutsui.
  • Journal Title: Prog. Neurobiol. (in press)
  • Peer Reviewed
• [Journal Article] A new key neurohormone controlling reproduction, gonadotropin-inhibitory hormone(GnlH) in birds : disc overy, progress and prospect (review). (2009)
  • Author(s): K. Tsutsui, et al.
  • Journal Title: J. Neuroendocrinol. 21 Pages: 271-275
  • Peer Reviewed
• [Journal Article] GnIH : A Multifunctional Neuropeptide (review). (2009)
  • Author(s): G. E. Bentley, et al.
  • Journal Title: J. Neuroendocrinol. 21 Pages: 276-281
  • Peer Reviewed
• [Journal Article] Octopus GnRH (oot-GnRH), a multifunctional peptide in the endocrine and nervous systems of the cephalo pod (review). (2009)
  • Author(s): H. Minakata, et al.
  • Journal Title: J. Neuroendocrinol. 21 Pages: 322-326
  • Peer Reviewed
• [Journal Article] Evolutionary origin and divergence of GnlH and its homologous peptides (review). (2009)
  • Author(s): K. Tsutsui, T. Osugi.
  • Journal Title: Gen. Comp. Endocrinol. 161 Pages: 30-33
  • Peer Reviewed
• [Journal Article] Identification, biosynthesis and function of 7alpha-hydroxypregnenolone, a new key neurosteroid controlling locomotor activity, in non-mammals (review). (2009)
  • Author(s): K. Tsutsui, et al.
  • Journal Title: Ann. N. Y. Aoad. Sci. (in press)
  • Peer Reviewed
• [Journal Article] Hormone-mediated reproductive behavior in the red-bellied newt (review). (2009)
  • Author(s): S. Kikuyama, et al.
  • Journal Title: Ann. N. Y. Acad. Sci. (in press)
  • Peer Reviewed
• [Journal Article] Steroid Biosynthesis within the frog brain : A model of neuroendocrine regulation (review). (2009)
  • Author(s): J. L. Do Rego, et al.
  • Journal Title: Ann. N. Y. Acad. Sci. (in press)
  • Peer Reviewed
• [Journal Article] メラトニンとGnlHの光周性 (2009)
  • Author(s): 筒井和義
  • Journal Title: 光周性の分子生物学海老原・井澤編 (印刷中)
  • Peer Reviewed
• [Journal Article] メラトニンに関する最近の話題 : メラトニンとGnlH (2009)
  • Author(s): 筒井和義
  • Journal Title: 中外医学社V. 生殖医学 Pages: 190-195
  • Peer Reviewed
• [Journal Article] Changes in GnRH I, bradykinin and their receptors and GnIH in the ovary of Calotes versicolor during reproductive cycle. (2008)
  • Author(s): P.Singh, A.Krishna, R.Sridaran, K.Tsutsui
  • Journal Title: Gen.Comp.Endocrinol. 159巻 Pages: 158-169
  • Peer Reviewed
• [Journal Article] Alterations in RFamiderelated peptide expression are coordinated with the preovulatory luteinizing hormone surge. (2008)
  • Author(s): E.M.Gibson(筆頭著者), K.Tsutsui, et al.
  • Journal Title: Endocrinology 149巻 Pages: 4958-4969
  • Peer Reviewed
• [Journal Article] Potent action of RFRP-3 on pituitary gonadotropes indicative of an hypophysiotropic role in the negative regulation of gonadotropin secretion. (2008)
  • Author(s): I.J.Clarke(筆頭著者), K.Tsutsui, et al.
  • Journal Title: Endocrinology 149巻 Pages: 5811-5821
  • Peer Reviewed
• [Journal Article] Hypophysiotropic role of RFamide-related peptide-3 RFRP-3 in the inhibition of LH secretion in female rats. (2008)
  • Author(s): M.Murakami(筆頭著者), K.Tsutsui, et al.
  • Journal Title: J.Endocrinol. 199巻 Pages: 105-112
  • Peer Reviewed
• [Journal Article] 7α-Hydroxypregnenolone mediates melatonin action underlying diurnal locomotor rhythms. (2008)
  • Author(s): K.Tsutsui(筆頭著者), K.Inoue, et al.
  • Journal Title: J.Neurosci. 28巻 Pages: 2158-2167
  • Peer Reviewed
• [Journal Article] Melatonin stimulates the release of growth hormone and prolactin by inducing the expression of frog growth hormone-releasing peptide (fGRP) and its related peptide-2 (fGRP-RP-2) in the amphibian hypothalamus. (2008)
  • Author(s): V.S.Chowdhury(筆頭著者), K.Tsutsui, et al.
  • Journal Title: Endocrinology 149巻 Pages: 962-970
  • Peer Reviewed
• [Journal Article] Gonadotropin-inhibitory hormone and its receptor in the avian reproductive system. (2008)
  • Author(s): G.Bentley(筆頭著者), K.Tsutsui, et al.
  • Journal Title: Gen.Comp.Endocrinol. 156巻 Pages: 34-43
  • NAID: 10020188345
  • Peer Reviewed
• [Journal Article] Auditory stimulation of reproductive function in male Rufous-winged Sparrows, Aimophila carpalis. (2008)
  • Author(s): T.W.Small(筆頭著者), K.Tsutsui, et al.
  • Journal Title: Horm.Behav. 53巻 Pages: 28-39
  • Peer Reviewed
• [Journal Article] Cerebellum, a target for hormonal signaling. (2008)
  • Author(s): N.Koibuchi, J.Kimura-Kuroda, Y.Ikeda, K.Tsutsui
  • Journal Title: Cerebellum 7巻 Pages: 499-504
  • Peer Reviewed
• [Journal Article] Unique form and osmoregulatory function of a neurohypophysial hormone in a urochordate. (2008)
  • Author(s): K. Ukena, E. Iwakoshi-Ukena, A Hikosaka
  • Journal Title: Endocrinology 149巻 Pages: 5254-5261
  • Peer Reviewed
• [Journal Article] Review : Gonadotropin-inhibitory hormone (GnIH) : biosynthesis, mode of action and functional significance in birds. (2008)
  • Author(s): K.Tsutsui, G.E.Bentley
  • Journal Title: Avian Biol.Res. 1巻 Pages: 175-186
  • Peer Reviewed
• [Journal Article] Review : Neurosteroids in the Purkinje cell : Biosynthesis, mode of action and functional significance. (2008)
  • Author(s): 筒井和義
  • Journal Title: Mol.Neurobiol. 37巻 Pages: 116-125
  • Peer Reviewed
• [Journal Article] Review : Recent advances in reproductive neuroendocrinology : A role for the RFamide peptides in seasonal reproduction? (2008)
  • Author(s): T.J.Greives(筆頭著者), K.Tsutsui, et al.
  • Journal Title: Proc.R.Soc.B. 275巻 Pages: 1943-1951
  • Peer Reviewed
• [Journal Article] Review : Progesterone biosynthesis and action in the developing neuron. (2008)
  • Author(s): 筒井和義
  • Journal Title: Endocrinology 149巻 Pages: 2757-2761
  • Peer Reviewed
• [Journal Article] Neurosteroid synthesis and action in the cerebellum during development (Review). In : a special issue for "Cerebellum, a target for hormonal signaling". (2008)
  • Author(s): 筒井和義
  • Journal Title: Cerebellum 7巻 Pages: 502-504
  • Peer Reviewed
• [Journal Article] GnIHとGnIH同属ペプチド(LPXRFamide ペプチド): 構造と機能の普遍性と多様性 (2008)
  • Author(s): 筒井和義
  • Journal Title: 生化学 80巻 Pages: 849-854
  • NAID: 10022594510
• [Journal Article] Review : Neurosteroids in the Purkinje cell : Biosynthesis, mode of action and functional significance (2008)
  • Author(s): K. Tsutsui (単独)
  • Journal Title: Mol. Neurobiol 37 Pages: 116-125
  • Peer Reviewed
• [Journal Article] 7α-Hydroxypregnenolone mediates melatonin action underlying diurnal locomotor rhythms (2008)
  • Author(s): K. Tsutsui (筆頭) et.al. (著者5名)
  • Journal Title: J. Neurosci 28 Pages: 2158-2167
  • Peer Reviewed
• [Journal Article] Melatonin stimulates the release of growth hormone and prolactin by inducing the expression of frog growth hormone-releasing peptide (fGRP) and its related peptide (2008)
  • Author(s): V. S. Chowdhury (筆頭), K. Tsutsui (最終) et.al. (著者6名)
  • Journal Title: Endocrinology 149 Pages: 962-970
  • Peer Reviewed
• [Journal Article] Gonadotropin-inhibitory hormone neurons interact directly with gonadotropin-releasing hormone-I and -II neurons in European starling brain (2008)
  • Author(s): T. Ubuka (筆頭), K. Tsutsui (8番目) et.al. (著者9名)
  • Journal Title: Endocrinology 149 Pages: 268-278
  • Peer Reviewed
• [Journal Article] Changes in GnRH I, bradykinin and their receptors and GnlH in the ovary of Calotes versicolor during reproductive cycle. (2008)
  • Author(s): P. Singh, et al.
  • Journal Title: Gen. Comp. Endocrinol. 159 Pages: 158-169
  • Peer Reviewed
• [Journal Article] Alterations in RFamide-related peptide expression are coordinated with the preovulatory luteinizing hormone surge. (2008)
  • Author(s): E. M. Gibson, et al.
  • Journal Title: Endocrinology 149 Pages: 4958-4969
  • Peer Reviewed
• [Journal Article] Potent action of RFRP-3 on pituitary gonadotropes indicative of a hypophysiotropic role in the negative regulation of gonadotropin secretion. (2008)
  • Author(s): I. J. Clarke, et al.
  • Journal Title: Endocrinology 149 Pages: 5811-5821
  • Peer Reviewed
• [Journal Article] Hypophysiotropic role of RFamide-related peptide-3 in the inhibition of LH secretion in female rats. (2008)
  • Author(s): M. Murakami, et al.
  • Journal Title: J. Endocrinol. 199 Pages: 105-112
  • Peer Reviewed
• [Journal Article] Immunohistochemical detection and biological activities of CYP17 (P450c17) in the indifferent gonad of the frog Rana rugosa. (2008)
  • Author(s): N. Sakurai, et al.
  • Journal Title: J. Steroid Biochem. Mol. Biol. 112 Pages: 5-12
  • Peer Reviewed
• [Journal Article] 7alpha-Hydroxypregnenolone mediates melatonin action underlying diurnal locomotor rhythms. (2008)
  • Author(s): K. Tsutsui, et al.
  • Journal Title: J. Neuroscience 28 Pages: 2158-2167
  • Peer Reviewed
• [Journal Article] MeIatonin stimulates the release of growth hormone and proIactin by inducing the expression of frog growth hormone-releasing peptide and its related peptide-2 in the amphibian hypothalamus. (2008)
  • Author(s): V. S. Chowdhury, et al.
  • Journal Title: Endocrinology 149 Pages: 962-970
  • Peer Reviewed
• [Journal Article] Gonadotropin-inhibitory hormone neurons interact directly with gonadotropin-releasing hormone-l and -lI neurons in European starling brain. (2008)
  • Author(s): T. Ubuka, et al.
  • Journal Title: Endocrinology 149 Pages: 268-278
  • Peer Reviewed
• [Journal Article] Gonadotropin-inhibitory hormone and its receptor in the avian reproductive system. (2008)
  • Author(s): G. Bentley, et al.
  • Journal Title: Gen. Comp. Endocrinol. 156 Pages: 34-43
  • Peer Reviewed
• [Journal Article] Photoperiod-independent hypothalamic regulation of luteinizing hormone secretion in a free-living Sono ran desert bird, the Rufous-winged Sparrow (Aimophila carpalis). (2008)
  • Author(s): T. W. Small, et al.
  • Journal Title: Brain Behav. Evol. 71 Pages: 127-142
  • Peer Reviewed
• [Journal Article] Auditory stimulation of reproductive function in male Rufous-winged Sparrows, Aimophila carpalis. (2008)
  • Author(s): T. W. Small, et al.
  • Journal Title: Horm. Behav. 53 Pages: 28-39
  • Peer Reviewed
• [Journal Article] The orexigenic effect of GnlH is mediate by central opioid receptors in chicks. (2008)
  • Author(s): T. Tachibana, et al.
  • Journal Title: Comp. Biochem. Physiol. A Mol. Integr. Physiol. 150 Pages: 21-25
  • Peer Reviewed
• [Journal Article] Cerebellum, a target for hormonal signaling. (2008)
  • Author(s): N. Koibuchi, et al.
  • Journal Title: Cerebellum 7 Pages: 499-504
  • Peer Reviewed
• [Journal Article] Review : Gonadotropin-inhibitory hormone (GnlH) : biosynthesis, mode of action and functional significance in birds. (2008)
  • Author(s): K. Tsutsui, G. E. Bentley.
  • Journal Title: Avian Biol. Res. 1 Pages: 175-186
  • Peer Reviewed
• [Journal Article] Review : Neurosteroids in the Purkinje cell : Biosynthesis, mode of action and functional significance. (2008)
  • Author(s): K. Tsutsui.
  • Journal Title: Mol. Neurobiol. 37 Pages: 116-125
  • Peer Reviewed
• [Journal Article] Review : Recent advances in reproductive neuroendocrinology : A role for the RFamide peptides in seasonaI reproduction? (2008)
  • Author(s): T. J. Greives, et al.
  • Journal Title: Proc. R. Soc. B. 275 Pages: 1943-1951
  • Peer Reviewed
• [Journal Article] Review : Progesterone biosynthesis and action in the developing neuron. (2008)
  • Author(s): K. Tsutsui.
  • Journal Title: Endocrinology 149 Pages: 2757-2761
  • Peer Reviewed
• [Journal Article] Neurosteroid synthesis and action in the cerebellum during development (review). (2008)
  • Author(s): K. Tsutsui.
  • Journal Title: Cerebellum 7 Pages: 502-504
  • Peer Reviewed
• [Journal Article] Review : Expression, Iocalization and possible actions of 25-Dx, a membrane-associated putative progest erone-binding protein. in the developing Purkinje cell of the cerbellurn. (2008)
  • Author(s): H. Sakamoto, et al.
  • Journal Title: Cerebellum 7 Pages: 18-25
  • Peer Reviewed
• [Journal Article] 生殖神経内分泌学の新たな展開 : GnIHとキスペプチンの発見 (2008)
  • Author(s): 筒井和義
  • Journal Title: 増刊号「ホルモンの病態異常と臨床検査」臨床検査Journal of Medical Technology (医学書院) 52 Pages: 1207-1207
  • Peer Reviewed
• [Journal Article] GnIHとGnIH同属ペプチド(LPXRFamideペプチド) : 構造と機能の普遍性と多様性 (2008)
  • Author(s): 筒井和義
  • Journal Title: 生化学 80 Pages: 849-854
  • NAID: 10022594510
  • Peer Reviewed
• [Journal Article] 総説 : ステロイドのnon-genomic action 特集 : 合成ステロイドホルモン-最新の基礎・臨床研究- (2008)
  • Author(s): 徳元 俊伸, 筒井 和義
  • Journal Title: 日本臨床 66 Pages: 70-76
  • Peer Reviewed
• [Journal Article] 7alpha-Hydroxypregnenolone mediates melatonin action underlying diurnal locomotor rhythms. (2008)
  • Author(s): K.Tsutsui, et. al.
  • Journal Title: J Neuroscience 28 Pages: 2158-2167
  • Peer Reviewed
• [Journal Article] Melatonin stimulates the release of growth hormone and prolactin by inducing the expression of frog growth hormone-releasing peptide and its related peptide-2 in the amphibian hypothalamus. (2008)
  • Author(s): V.S.Chowdhury, et. al.
  • Journal Title: Endocrinology 149 Pages: 962-970
  • Peer Reviewed
• [Journal Article] Gonadotropin-inhibitory hormone neurons interact directly with gonadotropin-releasing hormone-I and -II neurons in European starling brain. (2008)
  • Author(s): T.Ubuka, et. al.
  • Journal Title: Endocrinology 149 Pages: 268-278
  • Peer Reviewed
• [Journal Article] Gonadotropin-inhibitory hormone and its receptor in the avian reproductive system. (2008)
  • Author(s): G.E.Bentley, et. al.
  • Journal Title: Gen.Comp.Endocrinol 156 Pages: 34-43
  • Peer Reviewed
• [Journal Article] Photoperiod-independent hypothalamic regulation of luteinizing hormone secretion in a free-living Sonoran desert bird, the Rufous-winged Sparrow(Aimophila carpalis). (2008)
  • Author(s): T.W.Small, et. al.
  • Journal Title: Brain Behav.Evol. 71 Pages: 127-142
  • Peer Reviewed
• [Journal Article] Auditory stimulation of reproductive function in male Rufous-winged Sparrows,Aimophila carpalis. (2008)
  • Author(s): T.W.Small, et. al.
  • Journal Title: Horm.Behav. 53 Pages: 28-39
  • Peer Reviewed
• [Journal Article] The orexigenic effect of GnIH is mediate by central opioid receptors in chicks. (2008)
  • Author(s): T.Tachibana, et. al.
  • Journal Title: Comp.Biochem.Physiol. (in press)
  • Peer Reviewed
• [Journal Article] Review:Neurosteroids in the Purkinje cell:Biosynthesis,mode of action and functional significance. (2008)
  • Author(s): K.Tsutsui
  • Journal Title: Mol.Neurobiol. (in press)
  • Peer Reviewed
• [Journal Article] Review:Recent advances in reproductive neuroendocrinology:A role for the RFamide peptides in seasonal reproduction? (2008)
  • Author(s): T.J.Greives, et. al.
  • Journal Title: Proc.R.Soc.B (in press)
  • Peer Reviewed
• [Journal Article] Review: Progesterone biosynthesis and action in the developing neuron. (2008)
  • Author(s): K.Tsutsui
  • Journal Title: Endocrinology (in press)
  • Peer Reviewed
• [Journal Article] Cerebellum,a target for hormonal signaling. (2008)
  • Author(s): N.Koibuchi, et. al.
  • Journal Title: Cerebellum (in press)
  • Peer Reviewed
• [Journal Article] Review: Expression,localization and possible actions of 25-Dx,a membrane-associated putative progesterone-binding protein,in the developing Purkinie cell of the cerebellum. (2008)
  • Author(s): H.Sakamoto, et. al.
  • Journal Title: Cerebellum (in press)
  • Peer Reviewed
• [Journal Article] Neurosteroid synthesis and action in the cerebellum during development(Review). (2008)
  • Author(s): K.Tsutsui
  • Journal Title: Cerebellum (in press)
  • Peer Reviewed
• [Journal Article] Gonadotropin-inhibitory hormone neurons interact directly with gonadotropin-releasing hormone-I and -II neurons in European starling brain. (2007)
  • Author(s): T.Ubuka (筆頭著者), K.Tsutsui, et al.
  • Journal Title: Endocrinology Endocrine news 149巻
  • Peer Reviewed
• [Journal Article] Mode of action and functional significance of estrogen inducing dendritic growth, spinogenesis and synaptogenesis in the developing Purkinje cell. (2007)
  • Author(s): K.Sasahara(筆頭著者), K.Tsutsui, et al.
  • Journal Title: J.Neurosci. 27巻 Pages: 7408-7417
  • Peer Reviewed
• [Journal Article] Rat RFamide-related peptide-3 stimulates GH secretion, inhibits LH secretion, and has variable effects on sex behavior in the adult male rat. (2007)
  • Author(s): M.A.Johnson, K.Tsutsui, G.S. Fraley
  • Journal Title: Horm.Behav. 51巻 Pages: 171-180
  • Peer Reviewed
• [Journal Article] Review : Discovery of gonadotropin-inhibitory hormone in a domesticated bird, its mode of action and functional significance. (2007)
  • Author(s): K.Tsutsui(筆頭著者), K.Ukena, etal.
  • Journal Title: J.Ornithol. 148巻(Suppl 2)
  • Peer Reviewed
• [Journal Article] Review : Gonadotropin-inhibitory hormone in seasonally-breeding songbirds : Neuroanatomy and functional biology. (2007)
  • Author(s): G.E.Bentley(筆頭著者), K.Ukena, K.Tsutsui, et al.
  • Journal Title: J.Ornithol. 148巻(Suppl 2)
  • Peer Reviewed
• [Journal Article] Comparative reproductive neuroendocrinology. (2007)
  • Author(s): P.J.Sharp, K.Tsutsui
  • Journal Title: Gen.Comp.Endocrinol. 153巻 Pages: 344-345
  • Peer Reviewed
• [Journal Article] Review : The general and comparative biology of gonadotropininhibitory hormone (GnIH). (2007)
  • Author(s): K.Tsutsui(筆頭著者), K.Ukena, et al.
  • Journal Title: Gen.Comp.Endocrinol. 153巻 Pages: 365-370
  • Peer Reviewed
• [Journal Article] 総説:GnIH特集/中枢内分泌の最新知見とその異常,産科と婦人科 (2007)
  • Author(s): 筒井和義
  • Journal Title: Obstet. Gynecol.;診断と治療社 74巻 Pages: 904-913
• [Journal Article] Mode of action and functional significance of estrogen inducing dendritic growth, spinogenesis and synaptogenesis in the developing Purkinje cell (2007)
  • Author(s): K. Sasahara (筆頭), K. Tsutsui (最終) et.al.(著者7名)
  • Journal Title: J. Neurosci 27 Pages: 7408-7417
  • Peer Reviewed
• [Journal Article] Mode of action and functional significance of estrogen inducing dendritic growth, spinogenesis and synaptogenesis in the develoaing Purkinie cell. (2007)
  • Author(s): K.Sasahara, et. al.
  • Journal Title: J Neuroscience 27 Pages: 7408-7417
  • Peer Reviewed
• [Journal Article] Rat RFamide-related peptide-3 stimulates GH secretion, inhibits LH secretion,and has variable effects on sex behavior in the adult male rat. (2007)
  • Author(s): M.A.Johnson, et. al.
  • Journal Title: Horm Behav. 51 Pages: 171-180
  • Peer Reviewed
• [Journal Article] Review:Discovery of gonadotropin-inhibitory hormone in a domesticated bird,its mode of action and functional significance. (2007)
  • Author(s): K.Tsutsui, et. al.
  • Journal Title: J.Ornithol. 148
  • Peer Reviewed
• [Journal Article] Review:Gonadotropin-inhibitory hormone in seasonally-breeding songbirds:Neuroanatomy and functional biology. (2007)
  • Author(s): G.E.Bentley, et. al.
  • Journal Title: J.Ornithol. 148
  • Peer Reviewed
• [Journal Article] Comparative reproductive neuroendocrinology. (2007)
  • Author(s): P.J.Sharp, et. al.
  • Journal Title: Gen.Comp.Endocrinol. 153 Pages: 344-345
  • Peer Reviewed
• [Journal Article] Review:The general and comparative biology of gonadotropin-inhibitory hormone(GnIH). (2007)
  • Author(s): K.Tsutsui, et. al.
  • Journal Title: Gen.Comp.Endocrinol. 153 Pages: 365-370
  • Peer Reviewed
• [Journal Article] Cerebellum, a target for hormonal signaling. (2007)
  • Author(s): N.Koibuchi et al.
  • Journal Title: Cerebellum (in press)
• [Journal Article] rat RFamide-related peptide-3 stimulates GH secretion, inhibits LH secretion, and has variable effects on sex behavior in the adult male rat. (2007)
  • Author(s): M.A.Johnson et al.
  • Journal Title: Horm Behav. 51 Pages: 171-180
• [Journal Article] Neurosteroid synthesis and action in the cerebellum during development (Review). (2007)
  • Author(s): K.Tsutsui
  • Journal Title: Cerebellum (in press)
• [Journal Article] Review : Discovery of gonadotropin-inhibitory hormone in a domesticated bird, and its mode of action and functional significance. (2007)
  • Author(s): K.Tsutsui et al.
  • Journal Title: J. Ornithol. (in press)
• [Journal Article] Review : Gonadotropin-inhibitory hormone in seasonally-breeding songbirds : Neuroanatomy and functional biology. (2007)
  • Author(s): G.E.Bentley et al.
  • Journal Title: J. Ornithol. (in press)
• [Journal Article] Review : The general and comparative biology of gonadotropin-inhibitory hormone (GnIH). (2007)
  • Author(s): K.Tsutsui et al.
  • Journal Title: Gen. Comp. Endocrinol. Epub ahead of print
• [Journal Article] membrane of water-permeable epithelial cells in osmoregulatoryorgans of the tree frog. (2007)
  • Author(s): G.Akabane et al.
  • Journal Title: Am. J. Physiol. Regul. Integr. Comp. Physiol. (In press)
• [Journal Article] Cloning and expression of the vacuolar proton-pumping ATPase subunits in the follicular epithelium of bullfrog endolymphatic Sac. (2007)
  • Author(s): S.Yajima et al.
  • Journal Title: Zool. Sci. 24 Pages: 147-157
• [Journal Article] Ocemotactic peptide fMetLeuPhe induces translocation of the TRPV2 channel in macrophages. (2007)
  • Author(s): M.Nagasawa et al.
  • Journal Title: J. Cell Physiol. 210 Pages: 692-701
• [Journal Article] Amphibian aquaporins and adaptation to terrestrial environments : A review. (2007)
  • Author(s): M.Suzuki et al.
  • Journal Title: Comp. biochem. Physiol. A Mol. Integr. Physiol. (In press)
• [Journal Article] Evolutionary origin and divergence of PQRFamide peptides and LPXRFamide peptides in the RFamide peptide family : Insights from novel lamprey RFamide peptides. (2006)
  • Author(s): T.Osugi K.Ukena, S.A.Sower, H.Kawauchi, K.Tsutsui
  • Journal Title: FEBS J. 273巻 Pages: 1731-1743
  • Peer Reviewed
• [Journal Article] Rapid inhibition of female sexual behavior by gonadotropin-inhibitory hormone (GnIH). (2006)
  • Author(s): G.E.Bentley(筆頭著者), K.Tsutsui, et al.
  • Journal Title: Horm.Behav. 49巻 Pages: 550-555
  • Peer Reviewed
• [Journal Article] Gonadotropin-inhibitory hormone inhibits gonadal development and maintenance by decreasing gonadotropin synthesis and release in male quail. (2006)
  • Author(s): T.Ubuka, K.Ukena, P.J.Sharp, G.E.Bentley, K.Tsutsui
  • Journal Title: Endocrinology 147巻 Pages: 1187-1194
  • Peer Reviewed
• [Journal Article] Novel fish hypothalamic neuropeptides stimulate the release of gonadotropins and growth hormone from the pituitary of sockeye salmon. (2006)
  • Author(s): M.Amano(筆頭著者), K.Ukena, K.Tsutsui, et al.
  • Journal Title: J.Endocrinol. 188巻 Pages: 417-423
  • Peer Reviewed
• [Journal Article] Identification and characterization of a gonadotropin-inhibitory system in the brains of mammals. (2006)
  • Author(s): L.J.Kriegsfeld(筆頭著者), K.Ukena, K.Tsutsui, et al.
  • Journal Title: Proc.Natl.Acad.Sci.USA 103巻 Pages: 2410-2415
  • Peer Reviewed
• [Journal Article] Review : Biosynthesis, mode of action and functional significance of neurosteroids in the developing Purkinje cell. (2006)
  • Author(s): 筒井和義
  • Journal Title: J.Steroid Biochem.Mol.Biol. 102巻 Pages: 187-194
  • Peer Reviewed
• [Journal Article] Review : Hypothalamic LPXRF-amide peptides in vertebrates : Identification, localization and hypophysiotropic activity. (2006)
  • Author(s): K.Tsutsui, K.Ukena
  • Journal Title: Peptides 27巻 Pages: 1121-1129
  • Peer Reviewed
• [Journal Article] Mode of action and functional significance of avian gonadotropin-inhibitory hormone (GnIH) : A review. (2006)
  • Author(s): K.Tsutsui(筆頭著者), K.Ukena, et al.
  • Journal Title: J.Exp.Zool. 305A巻 Pages: 801-806
  • Peer Reviewed
• [Journal Article] Review : Interactions of gonadotropin-releasing hormone (GnRH) and gonadotropin-inhibitory hormone (GnIH) in birds and mammals. (2006)
  • Author(s): G.E.Bentley(筆頭著者), K.Ukena, K.Tsutsui, et al.
  • Journal Title: J.Exp.Zool. 305A巻 Pages: 807-814
  • Peer Reviewed
• [Journal Article] Structures and diverse functions of frog growth hormone-releasing peptide (fGRP) and its related peptides (fGRP-RPs) : A review. (2006)
  • Author(s): K.Ukena(筆頭著者), K.Tsutsui, et al.
  • Journal Title: J.Exp.Zool. 305A巻 Pages: 815-821
  • Peer Reviewed
• [Journal Article] Review : Neurosteroids in the brain neuron : Biosynthesis, action and medicinal impact on neurodegenerative disease. (2006)
  • Author(s): K.Tsutsui, S.H.Mellon
  • Journal Title: Central Nerv.Syst.Agents Med.Chem. 6巻 Pages: 73-82
  • Peer Reviewed
• [Journal Article] Gonadotropin-inhibitory hormone inhibits gonadal development and maintenance by decreasing gonadotropin synthesis and release (2006)
  • Author(s): T. Ubuka (筆頭), K. Tsutsui (最終) et.al. (著者5名)
  • Journal Title: Endocrinology 47 Pages: 1187-1194
  • Peer Reviewed
• [Journal Article] Identification and characterization of a gonadotropin-inhibitory system in the brains of mammals (2006)
  • Author(s): L. J. Kriegsfeld (筆頭), K. Tsutsui (5番目) et.al. (著者6名)
  • Journal Title: Proc. Natl. Acad. Sci. USA 103 Pages: 2410-2415
  • Peer Reviewed
• [Journal Article] Gonadotropin-inhibitory hormoneinhibits gonadal development and maintenance by decreasing gonadotropin synthesis and release in male quail. (2006)
  • Author(s): T.Ubuka et al.
  • Journal Title: Endocrinology 147 Pages: 1187-1194
• [Journal Article] Identification and characterization of a gonadotropin-inhibitory system in the brains of mammals. (2006)
  • Author(s): L.J.Kriegsfeld et al.
  • Journal Title: Proc. Natl. Acad. Sci. USA 103 Pages: 2410-2415
• [Journal Article] Novel fish hypothalamic neuropeptides stimulate the release of gonadotropins and growth hormone from the pituitary of sockeye salmon. (2006)
  • Author(s): M.Amano et al.
  • Journal Title: J. endocrinology 188 Pages: 417-423
• [Journal Article] peptides in the RF amide peptide family : Insights from novel lamprey RF amide peptides. (2006)
  • Author(s): T.Osugi et al.
  • Journal Title: FEBS Journal 273 Pages: 1731-1743
• [Journal Article] Molecular cloning and functional characterization of a prolactin-releasing peptide homolog from Xenopus laevis. (2006)
  • Author(s): T.Sakamoto et al.
  • Journal Title: Peptides 27 Pages: 3347-3351
• [Journal Article] Rapid inhibition of female sexual behavior bu gonadotropin-inhibitory hormone (GnIH). (2006)
  • Author(s): G.E.Bentley et al.
  • Journal Title: Horm. Behav. 49 Pages: 550-555
• [Journal Article] Control of luteinizing hormone and testosterone secretion in a flexibly breeding male passerine, the Rufous-winged Sparrow, Aimophila carpalis. (2006)
  • Author(s): P.J.Deviche et al.
  • Journal Title: Gen. Comp. Endocrinol. 149 Pages: 226-235
• [Journal Article] Gonadotropin-nhibitory hormone in birds : possible mode of action. (2006)
  • Author(s): G.E.Bentley et al.
  • Journal Title: Acta Zool Sinica. 52 Pages: 178-182
• [Journal Article] and the suprachiasmatic nucleus with the paraventricular organ in the Japanese grass lizard (Takydromus tachydromoides). (2006)
  • Author(s): E.Kawano et la.
  • Journal Title: zool Sci. 23 Pages: 277-287
• [Journal Article] eview : Biosynthesis, mode of action and functional significance of neurosteroids in the developing Purkinje ell. (2006)
  • Author(s): K.Tsutsui
  • Journal Title: J. Steroid Biochem. Mol. Biol. 102 Pages: 187-194
• [Journal Article] review : Biosynthesis and organizing action of neurosteroids in the developing Purkinje cell. (2006)
  • Author(s): K.Tsutsui
  • Journal Title: Cerebellum 5 Pages: 89-96
• [Journal Article] Review : Hypothalamic LPXRF-amide peptides in vertebrates : Identification, localization and hypophysiotropic activity. (2006)
  • Author(s): K.Tsutsui et al.
  • Journal Title: Peptides 27 Pages: 1121-1129
• [Journal Article] review : Gonadotropin-Inhibitory Hormone (GnIH) : Discovery, Progress and Perspective. (2006)
  • Author(s): K.Tsutsui
  • Journal Title: K. Tsutsui 43 Pages: 191-198
• [Journal Article] Mode of action and functional signifcance of avian gonadotropin-inhibitory hormone (GnIH) : A review. (2006)
  • Author(s): K.Tsutsui et al.
  • Journal Title: K. Tsutsui et al. 305A Pages: 801-806
• [Journal Article] Revuew : ubteractuibs if gibaditrioub0rekeasubg girnibe (GnRH) and gonadotropin-inhibitory hormone (GnIH) in birds and mammals. (2006)
  • Author(s): G.E.Bentley et al.
  • Journal Title: J. Exp. Zool. 305A Pages: 807-814
• [Journal Article] Structures and diverse functions of frog growth hormone-releasing releasing peptide (fGRP) and its related peptides (fGRP-RPs) : A review. (2006)
  • Author(s): K.Ukena et al.
  • Journal Title: J. Exp. Zool. 305A Pages: 815-821
• [Journal Article] Neurosteroid biosynthesis in the quail brain : A review. (2006)
  • Author(s): K.Tsutsui et al.
  • Journal Title: J. Exp. Zool. 305A Pages: 733-742
• [Journal Article] Review : Neurosteroids in the brain neuron : Biosynthesis, action and medicinal impact on neurodegenerative disease. (2006)
  • Author(s): K.Tsutsui et al.
  • Journal Title: Central Nervous System Agents in Medicinal Chemistry 6 Pages: 73-82
• [Journal Article] Isolation and characterization of a novel small cardioactive peptide-related peptide from the brain of Octopus vulgaris. (2006)
  • Author(s): A.Kanda et al.
  • Journal Title: Peptides 27 Pages: 1755-1761
• [Journal Article] Gonadotropin-releasing-hormone receptor isolated from the common octopus (Octopus vulgaris). (2006)
  • Author(s): A.Kanda et al.
  • Journal Title: Biochem. J. 395 Pages: 125-135
• [Journal Article] effect of placental restriction on the development of subpopulations of corticotrophs in the fetal sheep pituitary during late gestation. (2006)
  • Author(s): K.Farrand et al.
  • Journal Title: Endocrinology 147 Pages: 4762-4771
• [Journal Article] A starvation-specific serine protease gene, isp6+, is involved in both autophagy and sexua development in Schizosaccharomyces pombe. (2006)
  • Author(s): A.Nakashima et al.
  • Journal Title: Curr. Genet. 49 Pages: 403-413
• [Journal Article] Molecular and cellular characterization of a new aquaporin, AQP-x5, specifically expressed in the small granular glands of Xenopus skin. (2006)
  • Author(s): M.Kubota et al.
  • Journal Title: J. Exp. Biol. 209 Pages: 3199-3208
• [Journal Article] Gene expression of vascular growth factor-A in the pituitary during formation of the vascular system in the hypothalamic-pituitary axis of the rat. (2006)
  • Author(s): T.Nakakura et al.
  • Journal Title: Cell Tissue Res. 324 Pages: 87-95
• [Journal Article] Review : Balancing reproduction by the inhibitory regulator GnIH and the stimulatory regulator kisspeptin. Trends Neurosci.
  • Author(s): K.Tsutsui(筆頭著者), G.E.Bentley, et al.
  • Journal Title: Cell Press (in press)
• [Presentation] Gonadotropin-inhibitory hormone (GnIH), a new key neurohormone controlling vertebrate reproduction : Biosynthesis, mode of action and functional significance. (2011)
  • Author(s): 筒井和義
  • Organizer: The 2011 International Biomodulation Symposium on 'Biomaterials and Biomodelling for Translational Research'
  • Place of Presentation: Seoul National University, Seoul, Korea.(基調講演)
• [Presentation] Putting the brakes on reproduction. Implications for conservation? Global climate change? (2010)
  • Author(s): J.C.Wingfield, K.Tsutsui
  • Organizer: Howard Bern Lecture at the Society of Integrative and Comparative Biology (SICB) meeting 2011
  • Place of Presentation: Salt Lake City, USA.(基調講演)
• [Presentation] Novel molecular mechanisms underlying diurnal locomotor rhythms in birds : Coordination of melatonin with 7α-hydroxypregnenolone, a newly discovered avian neurosteroid. (2010)
  • Author(s): 筒井和義
  • Organizer: The 25th International Ornithological Congress
  • Place of Presentation: Campos do Jordao, Brazil.(基調講演)
• [Presentation] Discovery and evolutionary history of GnIH and kisspeptin, new key neuropeptides controlling reproduction. (2010)
  • Author(s): 筒井和義
  • Organizer: The 7th International Congress of Neuroendocrinology
  • Place of Presentation: Rouen, France.(招待講演)
• [Presentation] Discovery of GnIH : First identification in birds and conservation in mammals. (2010)
  • Author(s): 筒井和義
  • Organizer: The Symposium "Gonadotropin inhibitory hormone (GnIH) functions in mammals " at The Endocrine Society's 92nd Annual Meeting
  • Place of Presentation: San Diego, California, USA.(基調講演)
• [Presentation] Discovery and functional significance of gonadotropin-inhibitory hormone (GnIH) in vertebrates : From comparative to general. (2010)
  • Author(s): 筒井和義
  • Organizer: The 14th International Congress of Endocrinology
  • Place of Presentation: Kyoto International Conference Center, Kyoto, Japan.(招待講演)
• [Presentation] Discovery and functional significance of gonadotropin-inhibitory hormone(GnIH)in vertebrates : From comparative to general (2010)
  • Author(s): 筒井和義
  • Organizer: The 14th International Congress of Endocrinology
  • Place of Presentation: Kyoto, Japan
• [Presentation] The President Address : Future Progress of the AOSCE (2010)
  • Author(s): 筒井和義
  • Organizer: The 6th AOSCE
  • Place of Presentation: Palmerston North, New Zealand
• [Presentation] 新規脳ホルモンの探索と生理機能の解析 (2009)
  • Author(s): 筒井和義
  • Organizer: 埼玉大学学術講演会
  • Place of Presentation: 埼玉市
  • Year and Date: 2009-12-11
• [Presentation] 生殖機能を制御する新規生理活性ペプチドGnIH (2009)
  • Author(s): 筒井和義
  • Organizer: 平成21年度日本内分泌学会サマーセミナー
  • Place of Presentation: 坂井市
  • Year and Date: 2009-07-16
• [Presentation] 生殖腺刺激ホルモン放出抑制ホルモン(GnIH)による生殖機能の制御 (2009)
  • Author(s): 筒井和義
  • Organizer: 第82回日本内分泌学会学術総会サテライトシンポジウム
  • Place of Presentation: 群馬県
  • Year and Date: 2009-04-24
• [Presentation] Phylogenetic aspects of gonadotropin-inhibitory hormone (GnIH) and its homologs in vertebrates. (2009)
  • Author(s): 筒井和義
  • Organizer: Satellite Symposium of the 9th International Symposium on VIP, PACAP and Related Peptides
  • Place of Presentation: Yakushima, Japan.(招待講演)
• [Presentation] New neuropeptides and neurosteroids in vertebrates : Discovery, progress and prospects. (2009)
  • Author(s): 筒井和義
  • Organizer: The 16th International Congress of Comparative Endocrinolog
  • Place of Presentation: Hong Kong, China.(基調講演)
• [Presentation] Phylogenetic aspects of gonadotropin-inhibitory hormone(GnIH)and its homologs in vertebrates (2009)
  • Author(s): 筒井和義
  • Organizer: Satellite Symposium of the 9th International Symposium on VIP, PACAP and Related Peptides
  • Place of Presentation: Yakushima, Japan
• [Presentation] Identification of a novel bioactive amphibian neurosteroid, 7α-hydroxypregnenolone, and its role in the regulation of the diurnal rhythm of locomotor activity in newts (2009)
  • Author(s): 筒井和義
  • Organizer: The 6th ISAREN
  • Place of Presentation: Berlin. Germany
• [Presentation] New neuropeptides and neurosteroids in vertebrates : Discovery, progress and prospects (2009)
  • Author(s): 筒井和義
  • Organizer: The 16th International Congress of Comparative Endocrinology
  • Place of Presentation: Hong Kong
• [Presentation] Gonadotropin-inhibitory hormone (GnIH) : discovery, progress and prospect. (2008)
  • Author(s): 筒井和義
  • Organizer: The 5th International Symposium on Molecular Endocrinology
  • Place of Presentation: Hormone Research Center, Gwangju, Korea.(基調講演)
  • Year and Date: 2008-04-04
• [Presentation] Gonadotropin-inhibitory hormone (GnIH) : discovery, progress and prospect (2008)
  • Author(s): K. Tsutsui
  • Organizer: The 5th International Symposium on Molecular Endocrinology(基調講演)
  • Place of Presentation: Gwangju, Korea
  • Year and Date: 2008-04-04
• [Presentation] Gonadotropin-inhibitory hormone (GnIH) : discovery, progress and prospect. (2008)
  • Author(s): K. Tsutsui.
  • Organizer: The 5th International Symposium on Molecular Endocrinology
  • Place of Presentation: Gwangju, Korea
  • Year and Date: 2008-04-04
• [Presentation] The novel neurosteroid 7alpha-hydroxypregnenolone is a key factor inducing sex-dependent locomotor activity (2008)
  • Author(s): K. Tsutsui
  • Organizer: 第85日本生理学会シンポジウム「性差の分子メカニズムMolecular Mechanisms of Sexual Differences)
  • Place of Presentation: 京王プラザホテル
  • Year and Date: 2008-03-27
• [Presentation] GnlHとGnlH同族ペプチドの多様性と分子進化 (2008)
  • Author(s): 筒井 和義
  • Organizer: 基礎生物学研究所研究会「生殖生物学の歴史と展望」
  • Place of Presentation: 岡崎カンファレンス
  • Year and Date: 2008-03-24
• [Presentation] Discovery of gonadotropininhibitory hormone (GnIH), and its mode of action and functional significance. (2008)
  • Author(s): 筒井和義
  • Organizer: US/Japan International Symposium on Neurosteroids
  • Place of Presentation: Gifu, Japan.(招待講演)
• [Presentation] Identification, biosynthesis and function of 7α-hydroxypregnenolone, a new key neurosteroid controlling locomotor activity. (2008)
  • Author(s): 筒井和義
  • Organizer: The 24th Conference European Comparative Endocrinologists
  • Place of Presentation: Genova, Italy.(基調講演)
• [Presentation] The novel avian neurosteroid 7α-hydroxypregnenolone mediates melatonin ction underlying diurnal locomotor rhythms. (2008)
  • Author(s): 筒井和義
  • Organizer: The 9th International Symposium on Avian Endocrinology
  • Place of Presentation: Leuven, Belgium.(Farner Medal 受賞講演)
• [Presentation] Evolutionary origin and divergence of GnIH and its homologous peptides. (2008)
  • Author(s): 筒井和義
  • Organizer: The 6th International Symposium on Fish Endocrinology and Neuroendocrinology
  • Place of Presentation: Calgary, Canada.(基調講演)
• [Presentation] The novel avian neurosteroid 7α-hydroxypregnenolone mediates melatonin action underlying diurnal locomotor rhythms (2008)
  • Author(s): K. Tsutsui
  • Organizer: The 9th International Symposium on Avian Endocrinology(Farner Medal 受賞講演)
  • Place of Presentation: Leuven, Belgium
• [Presentation] Evolutionary origin and divergence of GnIH and its homologous peptides (2008)
  • Author(s): K. Tsutsui
  • Organizer: The 6th International Symposium on Fish Endocrinology and Neuroendocrinology(基調講演)
  • Place of Presentation: Calgary, Canada
• [Presentation] Novel molecular mechanism inducing sex difference in locmotor activity by 7alpha-hydroxypregnenolone, a newly discovered neurosteroid. (2008)
  • Author(s): K. Tsutsui.
  • Organizer: International Symposium for Gonad and Brain Sex Differentiation
  • Place of Presentation: Fukuoka, Japan
• [Presentation] Discovery of gonadotropin-inhibitory hormone (GnIH), and its mode of action and functional significance. (2008)
  • Author(s): K. Tsutsui.
  • Organizer: US/Japan International Symposium on Neurosteroids
  • Place of Presentation: Gifu, Japan
• [Presentation] Rapid stimulation of Iocomotor activity by 7alpha-hydroxypregnenolone identified as a novel neuronal a otivator. (2008)
  • Author(s): S. Haraguchi, K. Tsutsui.
  • Organizer: US/Japan International Symposium on Neurosteroids
  • Place of Presentation: Gifu, Japan
• [Presentation] Identification, biosynthesis and function of 7alpha-hydroxypregnenolone, a new key neurosteroid controlling locomotor activity. (2008)
  • Author(s): K. Tsutsui.
  • Organizer: The 24th Conference European Comparative Endocrinologists
  • Place of Presentation: Genova, Italy
• [Presentation] Hormone-mediated reproductive behavior in the newt. (2008)
  • Author(s): S. Kikuyama, K. Tsutsui.
  • Organizer: The 24th Conference European Comparative Endocrinologists
  • Place of Presentation: Genova, Italy
• [Presentation] The novel avian neurosteroid 7alpha-hydroxypregnenolone mediates melatonin action underlying diurnal locomotor rhythms. (2008)
  • Author(s): K. Tsutsui.
  • Organizer: The 9th International Symposium on Avian Endocrinology
  • Place of Presentation: Leuven, Belgium
• [Presentation] Evolutionary origin and divergence of GnIH and its homologous peptides. (2008)
  • Author(s): K. Tsutsui.
  • Organizer: The 6th International Symposium on Fish Endocrinology and Neuroendocrinology
  • Place of Presentation: Calgary, Canada
• [Presentation] Neurosteroid synthesis and action in the cerebellar Purkinje cell (2007)
  • Author(s): K. Tsutsui
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会合同大会シンポジウム「局所ステロイドの合成と機能」
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-12-12
• [Presentation] イモリから同定した新規ニューロステロイドの生理作用 (2007)
  • Author(s): 筒井 和義
  • Organizer: 日本動物学会第78回大会シンポジウム「両生類はワンダーランド」
  • Place of Presentation: 弘前大学
  • Year and Date: 2007-09-22
• [Presentation] ニューロステロイド合成の日周性とメラトニンによる調節 (2007)
  • Author(s): 筒井 和義
  • Organizer: 第29回日本比較生理生化学会シンポジウム「生体リズムにおける振動制御機構と出力機構〜研究の現状と新展開〜」
  • Place of Presentation: 岡山大学
  • Year and Date: 2007-07-06
• [Presentation] 烏類から発見された生殖腺刺激ホルモン放出抑制ホルモン(GnlH)とその受容体 (2007)
  • Author(s): 筒井 和義
  • Organizer: 第4回GPCR研究会シンポジウム「GPCRと内分泌・生殖機能」
  • Place of Presentation: 日本科学未来館
  • Year and Date: 2007-05-12
• [Presentation] Gonadotropin-inhibitory hormone (GnIH) in a new reproductive axis. (2007)
  • Author(s): 筒井和義
  • Organizer: The 6th Congress of the Asia and Oceania Society for Comparative Endocrinology
  • Place of Presentation: Siliguri, India.(基調講演)
• [Presentation] Gonadotropin-inhibitory hormone (GnIH) : discovery, mode of action, functional significance and prospective application to reproductive dysfunction. (2007)
  • Author(s): 筒井和義
  • Organizer: The 5th Anniversary Congress of International Drug Discovery Science and Technology (IDDST)-2007
  • Place of Presentation: Xi'an, China.(基調講演)
• [Presentation] Structures, diverse actions and functional significance of frog growth hormone-releasing peptide (fGRP) and its related peptides (fGRP-RPs). (2007)
  • Author(s): 筒井和義
  • Organizer: International Symposium on Amphibian and Reptile Endocrinology and Neurobiology
  • Place of Presentation: Conference Center at the Berkeley Marina, Berkeley, California, USA.(基調講演)
• [Presentation] Gonadotropin-inhibitory hormone(GnIH)in a new reproductive axis (2007)
  • Author(s): K. Tsutsui
  • Organizer: The 6th Congress of the Asia and Oceania Society for Comparative Endocrinology
  • Place of Presentation: Siliguri,India
• [Presentation] Gonadotropin-inhibitory hormone(GnIH): discovery,mode of action,functional significance and prospective application to reproductive dysfunction (2007)
  • Author(s): K. Tsutsui
  • Organizer: The 5th Anniversary Congress of Internationa l Drug Discovery Science and Technology (IDDST)-2007
  • Place of Presentation: Xi'an,China
• [Presentation] Melatonin regulates the production of 7alpha-hydroxvpregnenolone identified as an active neurosteroid stimulating locomotor activity in vertebrates (2007)
  • Author(s): K. Tsutsui
  • Organizer: The 2nd World Congress of Chronobiology
  • Place of Presentation: Tokyo,Japan
• [Presentation] The comparative biology of gonadotrophin-inhibitory hormone (GnIH) and its homologous peptides. (2006)
  • Author(s): 筒井和義
  • Organizer: The 23rd Conference of European Comparative Endocrinologists
  • Place of Presentation: The University of Manchester, Manchester, UK. (基調講演)
• [Presentation] Discovery of gonadotropininhibitory hormone in a domesticated bird, its mode of action and functional significance. (2006)
  • Author(s): 筒井和義
  • Organizer: The 24th International Ornithological Congress
  • Place of Presentation: Hamburg, Germany.(基調講演)
• [Presentation] Biosynthesis, mode of action and functional significance of neurosteroids in the developing Purkinje cell. (2006)
  • Author(s): 筒井和義
  • Organizer: The 17th International Symposium of the Journal of Steroid Biochemistry and Molecular Biology
  • Place of Presentation: Seefeld, Tyrol, Austria.(招待講演)
• [Presentation] Discovery of gonadotropininhibitory hormone in a domesticated bird, its mode of action and functional significance (2006)
  • Author(s): K. Tsutsui
  • Organizer: The 24th International Ornithological Congress(基調講演)
  • Place of Presentation: Hamburg, Germany
• [Presentation] The comparative biology of gonadotrophin-inhibitory hormone (GnIH) and its homologous peptides
  • Author(s): K. Tsutsui
  • Organizer: The 23rd Conference of European Comparative Endocrinologists(基調講演)
  • Place of Presentation: Manchester, UK
• [Presentation] その他42件
• [Book] Handbook of Cerebellum and Cerebellar Disorders (2011)
  • Author(s): 筒井和義
  • Publisher: Springer(in press)
• [Book] Phylogenetic Aspects of Neuropeptides : From Invertebrates to Humans (2010)
  • Author(s): 筒井和義
  • Publisher: Blackwell, Boston, Massachusetts
• [Book] Melatonin : From Molecules to Therapy (2007)
  • Author(s): K.Tsutsui, T.Ubuka, G.E.Bentley
  • Publisher: Nova Science Publishers, New York
• [Book] Hormone Biotechnology (2007)
  • Author(s): 筒井和義
  • Publisher: Daya Publishing House, Delhi
• [Book] Evolutionary Molecular Strategies and Plasticity (2007)
  • Author(s): 筒井和義
  • Publisher: Research Signpost Publishers,Trivandrum, India
• [Book] ホルモンハンドブック新訂eBook版(日本比較内分泌学会編) (2007)
  • Author(s): 筒井和義
  • Publisher: 南江堂
• [Book] シリーズ21世紀の動物科学10内分泌と生命現象 (2007)
  • Author(s): 筒井和義,浮穴和義,南方宏之
  • Publisher: 培風館
• [Book] Melatonin action on neuropeptide induction through receptor-mediated mechanisms in the brain. Melatonin : From Molecules to Therapy, (S.R. Pandi-Perumal and D. P. Cardinali) (2007)
  • Author(s): K. Tsutsui, T. Ubuka and G. E. Bentley
  • Total Pages: 14
  • Publisher: Nova Science Publishers, New York
• [Book] Gonadotropin-inhibitory hormone (GnIH) in the avian brain. Hormone Biotechnology, (S.K. Maitra) (2007)
  • Author(s): K. Tsutsui
  • Total Pages: 7
  • Publisher: Daya Publishing House, Delhi
• [Book] Melatonin action on neuropeptide induction through receptor-mediated mechanisms in the brain.In:Melatonin:From Molecules to Therapy. (2007)
  • Author(s): K.Tsutsui, et. al.
  • Total Pages: 14
  • Publisher: Nova Science Publishers,New York
• [Book] Gonadotropin-inhibitory hormone (GnIH) in the avian brain.In: Hormone Biotechnology. (2007)
  • Author(s): K.Tsutsui
  • Total Pages: 7
  • Publisher: Daya Publishing House,Delhi
• [Book] Neuronal neurosteroidogenesis and organizing actions of neurosteroids during cerebellar development.In:Evolutionary Molecular Strategies and Plasticity. (2007)
  • Author(s): K.Tsutsui
  • Total Pages: 18
  • Publisher: Research Signpost Publishers,Trivandrum
• [Book] 脳ホルモンの新領域シリーズ21世紀の動物科学10内分泌と生命現象第5章脳ホルモンの新領域長浜嘉孝・井口泰泉共編 (2007)
  • Author(s): 筒井 和義, et. al.
  • Total Pages: 39
  • Publisher: 培風館
• [Book] ホルモンハンドブック新訂eBook版2章ペプチドとタンパク質(無脊椎動物)日本比較内分泌学会編 (2007)
  • Author(s): 松島 治, et. al.
  • Total Pages: 27
  • Publisher: 南江堂
• [Book] ホルモンハンドブック新訂eBook版2章ペプチドとタンパク質(無脊椎動物)日本比較内分泌学会編 (2007)
  • Author(s): 南方 宏之
  • Total Pages: 99
  • Publisher: 南江堂
• [Book] ホルモンハンドブック新訂eB00k版脂溶性情報分子(細胞内受容体結合分子ファミリー)日本比較内分泌学会編 (2007)
  • Author(s): 筒井 和義
  • Total Pages: 130
  • Publisher: 南江堂
• [Book] Melatonin actio on neuropeptide induction through receptor-mediated mechanisms in the brain. (2007)
  • Author(s): K.Tsutsui et al.
  • Publisher: In : Melatonin : From Molecules to Therapy, S.R. Pandi-Perumal and D. P. Cardinali (eds) Nova Serence Publishers, New York(in press)
• [Book] Gonadotropin-inhibitory hormone (GnIH) in the avian brain. (2007)
  • Author(s): K.Tsutsui
  • Total Pages: 7
  • Publisher: In : Hormone Biotechnology, S. K. Maitra (ed), Daya Publishing House, Delhi
• [Book] Neuronal neurosteroidogenesis and organizing actions of neurosteroids during cerebellar development. (2007)
  • Author(s): K.Tsutsui
  • Total Pages: 18
  • Publisher: In : Evolutionary Molecular Strategies and Plasticity, M. Canonaco and R. M. Facciolo (eds) Research Signpost Publishers, Trivandrum, India
• [Book] 動物のアクアポリンの多様性と比較内分泌的展望 特集 新しい内分泌現象 日本比較内分泌学会ニュース124 (2007)
  • Author(s): 田中滋康 et al.
  • Total Pages: 16
  • Publisher: 日本比較内分泌学会
• [Book] Reproductive Biology and Phylogeny of Birds (2006)
  • Author(s): G.E.Bentley, K.Tsutsui, J.C.Wingfield
  • Publisher: Science Publishers, Enfield, USA
• [Book] The Handbook of Biologically Active Peptides (2006)
  • Author(s): N.Chartrel, K.Tsutsui, J.Costentin, H.Vaudry.
  • Publisher: Elsevier publisher
• [Book] Endocrinology of reproduction. Reproductive Biology and Phylogeny of Birds, (Barrie G. M. Jamieson) (2006)
  • Author(s): G. E. Bentley, K. Tsutsui and J. C. Wingfield.
  • Total Pages: 62
  • Publisher: Bentley Science Publishers, Enfield, USA
• [Book] Endocrinology of reproduction. (2006)
  • Author(s): G.E.Bentley et al.
  • Total Pages: 62
  • Publisher: In : Reproductive Biology and Phylogeny of Birds, Barrie G. M. Jamieson (ed) Science Publishers, Enfield, USA
• [Book] Avian gonadotropin-inhibitory hormone (GnIH) : Identification, mode of action and functional significance. (2006)
  • Author(s): K.Tsutsui
  • Total Pages: 5
  • Publisher: In : Comparative Endocrinology and Biodiversity in Asia and Oceania, P. Tangpraprutgul et al. (eds) Chulalongkorn University Press, Bangkok
• [Book] Melatonin action on the induction of gonadotropin-inhibitory hormone in the avian brain. (2006)
  • Author(s): v.S.Chowdhury et al.
  • Total Pages: 4
  • Publisher: In : Comparative Endocrinology and Biodiversity in Asia and Oceania, P. Tangpraprutgul et al. (eds) Chulalongkorn University Press, Bangkok
• [Book] The RF amide-related peptides. (2006)
  • Author(s): N.Chartrel et al.
  • Total Pages: 8
  • Publisher: In : The Handbook of Biologically Active Peptides, A. J. Kastin (ed) Elsevier publisher
• [Book] オキシトシン/バソプレッシンスーパーファミリーの進化「生物進化の分子マップ」生体の科学,57巻 (2006)
  • Author(s): 南方宏之
  • Total Pages: 2
  • Publisher: (財)金原一郎記念医学医療振興財団/医学書院
• [Book] 免疫染色＆ in situハイブリダイゼーション 最新プロトコール(野地澄晴編) (2006)
  • Author(s): 田中英明 et al.
  • Total Pages: 28
  • Publisher: 羊土社
• [Book] 甲状腺の分化に関連sる遺伝子Nkx.2.1の分子進化In : 生物進化の分子マップ,生体の科学 57 (2006)
  • Author(s): 鈴木雅一 et al.
  • Total Pages: 2
  • Publisher: 医学書院
• [Remarks] プレスリリース
• [Remarks] 2009年12月24日読売新聞掲載
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• [Remarks] Farner Medal, International Society for Avian Endocrinology, 2008
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• [Patent(Industrial Property Rights)] 新規メタスチン同族体およびその用途 (2008)
  • Inventor(s): 筒井和義
  • Industrial Property Rights Holder: 筒井和義
  • Filing Date: 2008-09-30
• [Patent(Industrial Property Rights)] 新規メタスチン同族体およびその用途 (2008)
  • Inventor(s): 筒井和義
  • Industrial Property Rights Holder: 筒井和義
  • Industrial Property Number: 2008-253859
  • Filing Date: 2008-09-30