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Exploration and Identification of Biomarkers of Multiple Sclerosis which is relevant for Management and Research of MS

Research Project

Project/Area Number 18109009
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Neurology
Research InstitutionNational Center of Neurology and Psychiatry

Principal Investigator

YAMAMURA Takashi  National Center of Neurology and Psychiatry, 神経研究所免疫研究部, 部長 (90231670)

Co-Investigator(Kenkyū-buntansha) ARANAMI Toshimasa  独)国立精神・神経医療研究センター, 神経研究所免疫研究部, 室長 (60435724)
MIYAKE Sachiko  独)国立精神・神経医療研究センター, 研究所免疫研究部, 室長 (50266045)
Project Period (FY) 2006 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥134,680,000 (Direct Cost: ¥103,600,000、Indirect Cost: ¥31,080,000)
Fiscal Year 2010: ¥22,100,000 (Direct Cost: ¥17,000,000、Indirect Cost: ¥5,100,000)
Fiscal Year 2009: ¥22,100,000 (Direct Cost: ¥17,000,000、Indirect Cost: ¥5,100,000)
Fiscal Year 2008: ¥27,690,000 (Direct Cost: ¥21,300,000、Indirect Cost: ¥6,390,000)
Fiscal Year 2007: ¥27,690,000 (Direct Cost: ¥21,300,000、Indirect Cost: ¥6,390,000)
Fiscal Year 2006: ¥35,100,000 (Direct Cost: ¥27,000,000、Indirect Cost: ¥8,100,000)
Keywords神経科学 / 脳神経疾患 / マイクロアレイ / 免疫学 / 薬剤反応性 / 多発性硬化症 / バイオマーカー / NK細胞 / CD11c / サイトカント / Th17細胞 / ケモカイン受容体 / 免疫制御機構 / クラスタリン / NR4A2
Research Abstract

By analyzing blood and cerebrospinal fluid (CSF) samples with DNA microarray and flow cytometry, we have attempted to identify biomarkers useful for diagnosis and treatment of multiple sclerosis (MS) and neuromyelitis optica (NMO). We successfully identified a T cell subset expanded in the CSF of MS and a B cell subset expanded in the blood of NMO. These results offer a novel method to make correct diagnosis and lead to development of new therapies targeting these expanded populations.

Report

(7 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report   Self-evaluation Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (87 results)

All 2011 2010 2009 2008 2007 2006 Other

All Journal Article (41 results) (of which Peer Reviewed: 16 results) Presentation (33 results) Book (9 results) Remarks (4 results)

  • [Journal Article] Interleukin 6 signaling promotes anti-aquaporin 4 autoantibody production from plasmablasts in neuromyelitis optica.2011

    • Author(s)
      Chihara N., T.Aranami, W.Sato Y.Miyazaki S.Miyake, T.Okamoto, M.Ogawa T.Toda, T.Yamamura
    • Journal Title

      PNAS 108

      Pages: 3701-3706

    • Related Report
      2010 Final Research Report
  • [Journal Article] Influenza A infection in suckling mice expands a population of NKT cells that protects mice as adults from airway hyperreactivity.2011

    • Author(s)
      Chang Y-J., H.Y.Kim, L.A.Albacker, et al.
    • Journal Title

      J.Clin.Invest. 121

      Pages: 57-69

    • Related Report
      2010 Final Research Report
  • [Journal Article] Interleukin 6 signaling promotes anti-aquaporin 4 autoantibody production from plasmablasts in neuromyelitis optica2011

    • Author(s)
      Norio Chihara, Toshimasa Aranami, Wakiro Sato, Yusei Miyazaki, Sachiko Miyake, Tomoko Okamoto, Masafumi Ogawa, Tatsushi Toda, Takashi Yamamura
    • Journal Title

      Proc.Natl.Acad.Sci.U.S.A.

      Volume: 108(9) Pages: 3701-3706

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 神経疾患と炎症-多発性硬化症を中心に-2010

    • Author(s)
      千原典夫、山村隆
    • Journal Title

      最新医学

      Volume: 11月号 Pages: 2390-2395

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 神経疾患と分子マーカー:多発性硬化症2010

    • Author(s)
      千原典夫、山村隆
    • Journal Title

      Clinical Neuroscience

      Volume: 28巻12号 Pages: 1396-1399

    • Related Report
      2010 Annual Research Report
  • [Journal Article] MSの免疫病態のトピックス2010

    • Author(s)
      冨田敦子、荒浪利昌、山村隆
    • Journal Title

      Brain Medical

      Volume: 22巻 Pages: 25-30

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Suppression of experimental autoimmune encephalomyelitis by Ghrelin.2009

    • Author(s)
      Theil M.M., S.Miyake, M.Mizuno, C.Tomi, J.L.Croxford, H.Hosoda, J.Theil, S.von Hoersten, H.Yokote, A.Chiba, Y.Lin, S.Oki, T.Akamizu, K.Kangawa, T.Yamamura
    • Journal Title

      J.Immunol. 183

      Pages: 2859-2866

    • Related Report
      2010 Final Research Report
  • [Journal Article] Molecular network of the comprehensive multiple sclerosis brain lesion proteome.2009

    • Author(s)
      Satoh J.I., H.Tabunoki, T.Yamamura
    • Journal Title

      Mult.Scler. 15

      Pages: 531-541

    • Related Report
      2010 Final Research Report
  • [Journal Article] Molecular network of the comprehensive multiple sclerosis brain lesion proteome2009

    • Author(s)
      Satoh JI
    • Journal Title

      Mult Scler 15

      Pages: 531-541

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthetic retinoid AM80 inhibits Th17 cells and ameliorates EAE2009

    • Author(s)
      Klemann C
    • Journal Title

      Am J Pathol 174

      Pages: 2234-2245

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of experimental autoimmune encephalomyelitis by Ghrelin2009

    • Author(s)
      Theil, M.M
    • Journal Title

      J Immunol 183

      Pages: 2859-2866

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Carcinoembryonic antigen-related cell adhesion molecule 1 modulates experimental autoimmune encephalomyelitis via iNKT cell-dependent mechanism2009

    • Author(s)
      Fujita, M.
    • Journal Title

      Am J Pathol 175

      Pages: 1163-1123

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2009

    • Author(s)
      荒浪利昌
    • Journal Title

      多発性硬化症.炎症・再生医学事典(松島綱治, 西脇徹編集)(朝倉書店)

      Pages: 26-218

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2009

    • Author(s)
      岡本智子
    • Journal Title

      脱髄性疾患.急性散在性脳脊髄炎.『神経疾患・診療ガイドライン-最新の診療指針-』(編集 鈴木則宏)(総合医学社)

      Pages: 195-197

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Molecular network analysis of T-cell transcriptome suggests aberrant regulation of gene expression by NF-κB as a biomarker for relapse of multiple sclerosis.2008

    • Author(s)
      Satoh J-i., T.Misawa, H.Tabunoki, T.Yamamura
    • Journal Title

      Dis Markers 25

      Pages: 27-35

    • Related Report
      2010 Final Research Report
  • [Journal Article] Orphan nuclear receptor NR4A2 expressed in T cells from multiple sclerosis mediates production of inflammatory cytokines.2008

    • Author(s)
      Doi Y., S.Oki, T.Ozawa, H.Hohjoh, S.Miyake, T.Yamamura
    • Journal Title

      Proc Natl Acad Sci USA 105

      Pages: 8381-8386

    • Related Report
      2010 Final Research Report
  • [Journal Article] Th17 cells and autoimmune encephalomyelitis (EAE/MS).2008

    • Author(s)
      Aranami T., T.Yamamura
    • Journal Title

      Allergol.Int. 57

      Pages: 115-120

    • NAID

      10021246298

    • Related Report
      2010 Final Research Report
  • [Journal Article] Molecular network analysis of T-cell transcriptome suggests aberrant regulation of gene expression by NF-_B as a biomarker for relapse of multiple sclerosis2008

    • Author(s)
      Satoh, J-i., T. Misawa, H. Tabunoki, T. Yamamura
    • Journal Title

      Dis Markers 25

      Pages: 27-35

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Orphan nuclear receptor NR4A2 expressed in T cells from multiple sclerosis mediates production of inflammatory cytokines2008

    • Author(s)
      Doi, Y., S. Oki, T. Ozawa, H. Hohjoh, S. Miyake, T. Yamamura
    • Journal Title

      PNAS 105

      Pages: 8381-8386

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Treatment of Neuromyelitis Optica : Current Debate2008

    • Author(s)
      Okamoto, T., M. Ogawa, Y. Lin, M. Murata, S. Miyake, T. Yamamura
    • Journal Title

      Therapeutic Advances in Neurological Dis orders 1

      Pages: 43-52

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Th17 cells and autoimmune encephalomyelitis (EAE/MS)2008

    • Author(s)
      Aranami, T., T. Yamamura
    • Journal Title

      Allergol. Int. 57

      Pages: 115-120

    • NAID

      10021246298

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 話題. ヒトTh17細胞におけるケモカインリセプターの発現2008

    • Author(s)
      佐藤和貴郎, 荒浪利昌, 山村隆
    • Journal Title

      臨床免疫・アレルギー科 49

      Pages: 89-94

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Orphan nuclear receptor NR4A2 expressed in T cells from multiple sclerosis mediates production of inflammatory cytokines.2008

    • Author(s)
      Doi, Y.,
    • Journal Title

      Proc Natl Acad Sci U S A (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cutting Edge.Human Th17 cells are identified as bearing CCR2+CCR5-phenotype.2007

    • Author(s)
      Sato W., T.Aranami, T.Yamamura
    • Journal Title

      J.Immunol. 178

      Pages: 7525-7529

    • Related Report
      2010 Final Research Report
  • [Journal Article] Understanding the behavior of invariant NKT cells in autoimmune diseases.2007

    • Author(s)
      Yamamura T., K.Sakuishi, Zs.Illes, S.Miyake
    • Journal Title

      J.Neuroimmunol. 191

      Pages: 8-15

    • Related Report
      2010 Final Research Report
  • [Journal Article] Human Th17 cells are identified asbearing CCR2+CCR5- phenotype2007

    • Author(s)
      Sato, W., T. Aranami and T. Yamamura
    • Journal Title

      J.Immunol 178

      Pages: 7525-7529

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] TROY and LlNGO-1 expression in astrocytes and macrophages/microglia in MS brains2007

    • Author(s)
      Satoh, J-i.,
    • Journal Title

      Neuropathol and Applied Neurobiol 33

      Pages: 99-107

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detection of anti-Nogo receptor autoantibody in the serum of multiple sclerosis and controls.2007

    • Author(s)
      Onoue, H.,
    • Journal Title

      Acta Neurologica Scandin 115

      Pages: 153-160

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cutting Edge.Human Th17 cells are identified as bearing CCR2+CCR5-phenotype.2007

    • Author(s)
      Sato, W.,
    • Journal Title

      J.Immunol. 178

      Pages: 7525-7529

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant transcriptional regulatory network in T cells of multiplesclerosis.2007

    • Author(s)
      Satoh, J.,
    • Journal Title

      Neurosci.Lett 422

      Pages: 30-33

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Invariant NKT cells biased for IL-5 production act as crucial regulators of inflammation.2007

    • Author(s)
      Sakuishi, K..,
    • Journal Title

      J.Immunol 179

      Pages: 3452-3462

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 第二のNKT細胞2007

    • Author(s)
      山村 隆
    • Journal Title

      炎症と免疫 15

      Pages: 289-291

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Differential expression of CD11c by peripheral blood NK cells reflects temporal activity of multiple sclerosis.2006

    • Author(s)
      Aranami T., S.Miyake, T.Yamamura
    • Journal Title

      J.Immunol. 177

      Pages: 5659-5667

    • Related Report
      2010 Final Research Report
  • [Journal Article] T cellgene expression profiling identifies distinctsubgroups of Japanese multiple sclerosispatients2006

    • Author(s)
      Satoh, J., M. Nakanishi, F. Koike, H. Onoue, T. Aranami, T. Yamamoto, M. Kawai, S.Kikuchi, K. Nomura, K. Yokoyama, K. Ota, T. Saito, M. Ohta, S. Miyake, T. Kanda, T.Fukazawa and T. Yamamura
    • Journal Title

      J. Neuroimmunol 174

      Pages: 108-118

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Differential expression of CD11c byperipheral blood NK cells reflects temporalactivity of multiple sclerosis2006

    • Author(s)
      Aranami, T., S. Miyake and T. Yamamura
    • Journal Title

      J. Immunol 177

      Pages: 5659-5667

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] T cell gene expression profiling identifies distinct subgroups of Japanese multiple sclerosis patients2006

    • Author(s)
      Satoh, J-i., M.Nakanishi, F.Koike et al.
    • Journal Title

      J. Neuroimmunol. 174

      Pages: 108-118

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Microarrray analysis identifies a set of CXCR3 and CCR2 ligand chemokines as early interferon-β-responsive genes in peripheral blood lymphocytes : an implication for IFN-β related adverse effects in multiple sclerosis2006

    • Author(s)
      Satoh, J-i., Y.Nanri, H.Tabunoki et al.
    • Journal Title

      BMC Neurology 6

      Pages: 18-34

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Invariant Vα19i T cells regulate autoimmune inflammation2006

    • Author(s)
      Croxford, J.L., S.Miyake, Y-Y.Huang et al.
    • Journal Title

      Nat. Immunol. 7

      Pages: 987-94

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Differential expression of CD11c by peripheral blood NK cells reflects temporal activity of multiple sclerosis2006

    • Author(s)
      Aranami, T., S.Miyakeand, T.Yamamura
    • Journal Title

      J. Immunol. 177

      Pages: 5659-5667

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 多発性硬化症の病態 -免疫調節機構の破綻2006

    • Author(s)
      荒浪利昌, 山村 隆
    • Journal Title

      医学のあゆみ 219

      Pages: 125-128

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Increase of Ki-67+natural killer cells in multiple sclerosis patients treated with interferon-b combined with low-dose oral steroids.

    • Author(s)
      Sanvito L., A.Tomita, N.Chihara, T.Okamoto, M.Ogawa, B.Gran, T.Aranami, T.Yamamura
    • Journal Title

      J.Neuroimmunol. (in press)

    • Related Report
      2010 Final Research Report
  • [Presentation] Progress in pathophysiology in NMO and clinical implications2011

    • Author(s)
      Takashi Yamamura
    • Organizer
      The 5th Bochum-Dusseldorf MS symposium
    • Place of Presentation
      Bochum, Germany (Bochum conference center)
    • Year and Date
      2011-02-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] IL-6 signaling promotes anti-aquaporin 4 autoantibody production from plasmablasts in neuromyelitis optica(NMO)2010

    • Author(s)
      Takashi Yamamura
    • Organizer
      2010 Neuromyelitis optica roundtable conference.A rare approach to a rare disease
    • Place of Presentation
      Los Angeles, USA(The Beverly Hilton)
    • Year and Date
      2010-11-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] T cell subsets identified with chemokine receptors in MS2010

    • Author(s)
      Aranami T, Sato, Yamamura T
    • Organizer
      MS Immunology Seminar
    • Place of Presentation
      Nottingham, England(National College for School Leadership)
    • Year and Date
      2010-10-31
    • Related Report
      2010 Annual Research Report
  • [Presentation] Keynote lecture.Immunology of NK and NKT ells in MS2010

    • Author(s)
      Takashi Yamamura
    • Organizer
      MS Immunology Seminar
    • Place of Presentation
      Nottingham, England(National College for School Leadership)
    • Year and Date
      2010-10-31
    • Related Report
      2010 Annual Research Report
  • [Presentation] Auto-reactive anti-aquaporin 4 antibodies are secreted from peripheral plasma cell-like B cells in neuromyelitis optics2010

    • Author(s)
      Chihara N, Aranami T, Sato W, Miyazaki Y, Miyake S, Okamoto T, Ogawa M, Yamamura T
    • Organizer
      Kobe : 14th Internatinal Congress of Immunology 2010
    • Place of Presentation
      Kobe(神戸国際会議場)
    • Year and Date
      2010-08-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] CCR2+ CCR5+ CD4+ T cells enriched in cerebrospinal fluid of relapsing multiple sclerosis patients strongly express matrix metalloproteinase-9 and osteopontin2010

    • Author(s)
      Wakiro Sato, Atsuko Tomita, Youwei Lin, Masafumi Ogawa, Tomoko Okamoto, Miho Murata, Toshimasa Aranami, Takashi Yamamura
    • Organizer
      Kobe : 14th Internatinal Congress of Immunology 2010
    • Place of Presentation
      Kobe(神戸国際会議場)
    • Year and Date
      2010-08-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] Plasma cell-like B cells produce aquaporin 4 autoantibody in neuromyelitis optica2010

    • Author(s)
      Chihara N, Aranami T, Sato W, Miyazaki Y, Miyake S, Okamoto T, Ogawa M, Yamamura T
    • Organizer
      Kyoto : Neuroimmunology Kyoto Conference 2010
    • Place of Presentation
      Kyoto(京都ガーデンパレスホテル)
    • Year and Date
      2010-08-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] 多発性硬化症の基礎と臨床.レビュートーク「神経免疫と臨床免疫:現在の到達点」2010

    • Author(s)
      山村隆
    • Organizer
      第22回日本神経免疫学会
    • Place of Presentation
      東京、日経ホール
    • Year and Date
      2010-03-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] 免疫性神経疾患の治療戦略2009

    • Author(s)
      山村隆
    • Organizer
      日本レチノイド研究会第20回学術集会「AM80の開発から臨床まで」
    • Place of Presentation
      東京、慈恵医大
    • Year and Date
      2009-11-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] Treatment of NMO and MS : Can we use same drugs?2009

    • Author(s)
      山村隆
    • Organizer
      International Symposium New Aspects of Neuromyelitis Optica(NMO)
    • Place of Presentation
      淡路島、Awaji Yumebutai kokusaikaigijyou
    • Year and Date
      2009-10-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] Opening lecture-Multiple sclerosis research in Japan : past, present and future2009

    • Author(s)
      山村隆
    • Organizer
      Second German-Japanese Neuroimmunology Symposium
    • Place of Presentation
      Eibsee、Eibsee Hotel, Germany
    • Year and Date
      2009-07-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] Orphan nuclear receptor NR4A2 and inflammatory cascade of MS/EAE. Plenary Session. Effector Mechanisms2008

    • Author(s)
      Yamamura T
    • Organizer
      IXth International Congress of Neuroimmunology, Sheraton Fort Worth Hotel and Spa, Fort Worth
    • Place of Presentation
      Texas, USA
    • Year and Date
      2008-10-29
    • Related Report
      2010 Final Research Report
  • [Presentation] Orphan nuclear receptorNR4A2 and inflammatory cascade ofMS/EAE2008

    • Author(s)
      Yamamura, T
    • Organizer
      IXthInternational Congress ofNeuroimmunology
    • Place of Presentation
      Fort Worth, Texas, USA
    • Year and Date
      2008-10-29
    • Related Report
      2008 Self-evaluation Report
  • [Presentation] Orphan nuclear receptor NR4A2 and inflammatory cascade of MS/EAE2008

    • Author(s)
      Yamamura, T
    • Organizer
      IXth International Congress of Neuroimmunology
    • Place of Presentation
      Fort Worth, Texas, USA
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] 多発性硬化症の病態解析から治療標的の同定へ2008

    • Author(s)
      山村隆
    • Organizer
      日本臨床免疫学会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-18
    • Related Report
      2008 Annual Research Report 2008 Self-evaluation Report
  • [Presentation] 多発性硬化症の分子病態と治療標的2008

    • Author(s)
      山村隆
    • Organizer
      日本臨床分子医学会
    • Place of Presentation
      神戸
    • Year and Date
      2008-07-24
    • Related Report
      2008 Annual Research Report 2008 Self-evaluation Report
  • [Presentation] 免疫疾患としての多発性硬化症2008

    • Author(s)
      山村隆
    • Organizer
      日本神経学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2008-05-16
    • Related Report
      2008 Annual Research Report 2008 Self-evaluation Report
  • [Presentation] 特別講演 V. 免疫制御システムと神経免疫疾患2008

    • Author(s)
      山村隆
    • Organizer
      第20回日本神経免疫学会
    • Place of Presentation
      新潟
    • Year and Date
      2008-04-17
    • Related Report
      2008 Self-evaluation Report
  • [Presentation] 特別講演V. 免疫制御システムと神経免疫疾患2008

    • Author(s)
      山村隆
    • Organizer
      第20回日本神経免疫学会
    • Place of Presentation
      新潟
    • Year and Date
      2008-04-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] Regulatory networks inthe immune system2007

    • Author(s)
      Yamamura, T
    • Organizer
      International Symposium on MultipleSclerosis-advances in basic researchand immunotherapy- Im Horsaalzentrumdes Katholischen Klinikums Bochum
    • Place of Presentation
      Bochum, Germany
    • Year and Date
      2007-12-08
    • Related Report
      2008 Self-evaluation Report
  • [Presentation] Regulatory networks in the immune system2007

    • Author(s)
      Yamamura, T.
    • Organizer
      lntemational Symposium on Multiple Sclerosis-advances in basic research and immunotherapy.lm Horsaalzentrum des KatholischenKlinikums Bochum
    • Place of Presentation
      Bochum, Germany
    • Year and Date
      2007-12-08
    • Related Report
      2007 Annual Research Report
  • [Presentation] The role of IL-5producing NK and NKT cells in the humanimmune homeostasis2007

    • Author(s)
      Yamamura, T
    • Organizer
      Symposium 8. Human immunity and immuneintervention. The 35^<th> Annual Meetingof the Japanese Society of Immunology
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-11-21
    • Related Report
      2008 Self-evaluation Report
  • [Presentation] The role of IL-5 producing NK and NKT cells in the human immune homeostasis.2007

    • Author(s)
      Yamamura, T.
    • Organizer
      Symposium 8. Human immunity and immuneintervention.The 35th Annual Meeting of the Japanese Society of Immunology
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-11-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] Microarray analysisidentifies distinct subgroups ofJapanese multiple sclerosis patients.Panel Session 5 Advancing MicroarrayTechnology in GeriatricPsychoneuropharmacology2007

    • Author(s)
      Yamamura, T
    • Organizer
      7^<th> Internatonal College of GeriatricPsychoneuropharmacology(ICGP)
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2007-11-01
    • Related Report
      2008 Self-evaluation Report
  • [Presentation] Microarray analysis identifies distinct subgroups of Japanesemultiple sclerosis patients-Panel Session 5 Advancing Microarray Technology in Geriatric Psychoneuropharmacology,2007

    • Author(s)
      Yamamura, T.
    • Organizer
      7th Internatonal College of Geriatric Psychoneuropharmacology(ICGP),
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2007-11-01
    • Related Report
      2007 Annual Research Report
  • [Presentation] 多発性硬化症の臨床免疫学2007

    • Author(s)
      山村隆
    • Organizer
      Plenary lecture 3.第35回日本臨床免疫学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2007-10-20
    • Related Report
      2008 Self-evaluation Report
  • [Presentation] 多発性硬化症の臨床免疫学2007

    • Author(s)
      山村 隆
    • Organizer
      Plenary lecture 3.第35回日本臨床免疫学会総会,
    • Place of Presentation
      大阪,
    • Year and Date
      2007-10-20
    • Related Report
      2007 Annual Research Report
  • [Presentation] Regulation ofAutoimmune Diseases by Invariant Tcells(NKT cells and MAIT cells)2007

    • Author(s)
      Yamamura, T
    • Organizer
      The 20th NAITO Conferenceon InnateImmunity in Medicine andBiology[III]
    • Place of Presentation
      Shonan Village Center
    • Year and Date
      2007-10-12
    • Related Report
      2008 Self-evaluation Report
  • [Presentation] Regulation of Autoimmune Diseases by Invariant T-cells(NKT cells and MAIT cells).2007

    • Author(s)
      Yamamura, T.
    • Organizer
      The 20th NAITO Conference on lnnate lmmunity in Medicine and Biology[III]
    • Place of Presentation
      Shonan Village Center
    • Year and Date
      2007-10-12
    • Related Report
      2007 Annual Research Report
  • [Presentation] Regulatory roles ofinvariant T cells in autoimmuneinflammation2007

    • Author(s)
      Yamamura, T
    • Organizer
      MainSymposium. Mechanisms of inflammatorydiseases. 13^<th> International Congressof Immunology
    • Place of Presentation
      Rio, Brazil
    • Year and Date
      2007-08-22
    • Related Report
      2008 Self-evaluation Report
  • [Presentation] Regulatory roles of invariant T cells in autoimmune inflammation2007

    • Author(s)
      Yamamura, T.
    • Organizer
      Main Symposium.Mechanisms of inflammatory diseases.13th lnternational Congress of Immunology
    • Place of Presentation
      Rio, Brazil
    • Year and Date
      2007-08-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] NK cells and multiplesclerosis : Do the innate cells mirror temporal disease activity?2007

    • Author(s)
      Yamamura, T
    • Organizer
      Pecs -Tubingen NeuroimmunologyDays 2007
    • Place of Presentation
      Pecs
    • Year and Date
      2007-04-13
    • Related Report
      2008 Self-evaluation Report
  • [Presentation] NK cells and multiple sclerosis: Do the innate cells mirror temporal disease activity?2007

    • Author(s)
      Yamamura, T.
    • Organizer
      Pecs-Tubingen Neuroimmunology Days 2007
    • Place of Presentation
      Pecs
    • Year and Date
      2007-04-13
    • Related Report
      2007 Annual Research Report
  • [Book] The Immune System Series "Results and Problems in Cell Differentiation"(Role of NK cells and NKT cells in multiple sclerosis. Molecular Basis of Multiple Sclerosis)(Roland Martin, and Andreas Lutterotti, ed 51 査読あり)2009

    • Author(s)
      Sakuishi K., S.Miyake, Yamamura T.
    • Publisher
      Springer-Verlag, Heidelberg
    • Related Report
      2010 Final Research Report
  • [Book] Role of NK cells and NKT cells in multiple sclerosis.Molecular Basis of Multiple Sclerosis.The Immune System Series "Results and Problems in Cell Differentiation"2009

    • Author(s)
      Sakuishi K
    • Publisher
      Springer-Verlag(Epub ahead of print)
    • Related Report
      2009 Annual Research Report
  • [Book] Results Probl Cell Differ2009

    • Author(s)
      Sakuishi K, Miyake S, Yamamura T
    • Publisher
      Role of NK Cells and Invariant NKTCells in Multiple Sclerosis
    • Related Report
      2008 Self-evaluation Report
  • [Book] 多発性硬化症の診断と治療2008

    • Author(s)
      荒浪利昌, 山村隆
    • Total Pages
      6
    • Publisher
      多発性硬化症の疾患活動性のマーカーとそのモニタリング
    • Related Report
      2008 Annual Research Report
  • [Book] Immune Regulation and Immunotherapy in Autoimmune Disease.(Editor Jingwu Zhang)(Invariant NKT cells and immune regulation in multiple sclerosis 査読なし)2007

    • Author(s)
      Yamamura T
    • Publisher
      Springer
    • Related Report
      2010 Final Research Report
  • [Book] unraveling the complexity2007

    • Author(s)
      Miyake S, Yamamura T
    • Total Pages
      314
    • Publisher
      NKT cells and autoimmune diseases
    • Related Report
      2008 Self-evaluation Report
  • [Book] Current Topics in Microbiology and lmmunology2007

    • Author(s)
      Miyake, S.
    • Total Pages
      17
    • Publisher
      Springer-Verlag
    • Related Report
      2007 Annual Research Report
  • [Book] In Immune Regulation and lmmunotherapy in Aufoimmune Disease2007

    • Author(s)
      Yamamura, T.
    • Total Pages
      13
    • Publisher
      Springer
    • Related Report
      2007 Annual Research Report
  • [Book] lmmune Regulation and Immunotherapy in Aufoimmune Disease2007

    • Author(s)
      Yamamura, T
    • Publisher
      Springer
    • Related Report
      2006 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.ncnp.go.jp/nin/guide/r_men/yamamura.html

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.ncnp.go.jp/nin/guide/r_men/yamamura-e.html

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.ncnp.go.jp/pdf/nin_topics_110324.pdf

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.ncnp.go.jp/pdf/nin_report_e.pdf

    • Related Report
      2010 Annual Research Report

URL: 

Published: 2006-04-01   Modified: 2016-04-21  

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