Exploration and Identification of Biomarkers of Multiple Sclerosis which is relevant for Management and Research of MS

• Project/Area Number: 18109009
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Neurology
• Research Institution: National Center of Neurology and Psychiatry
• Principal Investigator: YAMAMURA Takashi National Center of Neurology and Psychiatry, 神経研究所免疫研究部, 部長 (90231670)
• Co-Investigator(Kenkyū-buntansha): ARANAMI Toshimasa 独)国立精神・神経医療研究センター, 神経研究所免疫研究部, 室長 (60435724) ; MIYAKE Sachiko 独)国立精神・神経医療研究センター, 研究所免疫研究部, 室長 (50266045)
• Project Period (FY): 2006 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥134,680,000 (Direct Cost: ¥103,600,000、Indirect Cost: ¥31,080,000); Fiscal Year 2010: ¥22,100,000 (Direct Cost: ¥17,000,000、Indirect Cost: ¥5,100,000); Fiscal Year 2009: ¥22,100,000 (Direct Cost: ¥17,000,000、Indirect Cost: ¥5,100,000); Fiscal Year 2008: ¥27,690,000 (Direct Cost: ¥21,300,000、Indirect Cost: ¥6,390,000); Fiscal Year 2007: ¥27,690,000 (Direct Cost: ¥21,300,000、Indirect Cost: ¥6,390,000); Fiscal Year 2006: ¥35,100,000 (Direct Cost: ¥27,000,000、Indirect Cost: ¥8,100,000)
• Keywords: 神経科学 / 脳神経疾患 / マイクロアレイ / 免疫学 / 薬剤反応性 / 多発性硬化症 / バイオマーカー / NK細胞 / CD11c / サイトカント / Th17細胞 / ケモカイン受容体 / 免疫制御機構 / クラスタリン / NR4A2

Research Abstract

By analyzing blood and cerebrospinal fluid (CSF) samples with DNA microarray and flow cytometry, we have attempted to identify biomarkers useful for diagnosis and treatment of multiple sclerosis (MS) and neuromyelitis optica (NMO). We successfully identified a T cell subset expanded in the CSF of MS and a B cell subset expanded in the blood of NMO. These results offer a novel method to make correct diagnosis and lead to development of new therapies targeting these expanded populations.

Research Products

• [Journal Article] Interleukin 6 signaling promotes anti-aquaporin 4 autoantibody production from plasmablasts in neuromyelitis optica. (2011)
  • Author(s): Chihara N., T.Aranami, W.Sato Y.Miyazaki S.Miyake, T.Okamoto, M.Ogawa T.Toda, T.Yamamura
  • Journal Title: PNAS 108 Pages: 3701-3706
• [Journal Article] Influenza A infection in suckling mice expands a population of NKT cells that protects mice as adults from airway hyperreactivity. (2011)
  • Author(s): Chang Y-J., H.Y.Kim, L.A.Albacker, et al.
  • Journal Title: J.Clin.Invest. 121 Pages: 57-69
• [Journal Article] Interleukin 6 signaling promotes anti-aquaporin 4 autoantibody production from plasmablasts in neuromyelitis optica (2011)
  • Author(s): Norio Chihara, Toshimasa Aranami, Wakiro Sato, Yusei Miyazaki, Sachiko Miyake, Tomoko Okamoto, Masafumi Ogawa, Tatsushi Toda, Takashi Yamamura
  • Journal Title: Proc.Natl.Acad.Sci.U.S.A. Volume: 108(9) Pages: 3701-3706
  • Peer Reviewed
• [Journal Article] 神経疾患と炎症-多発性硬化症を中心に- (2010)
  • Author(s): 千原典夫、山村隆
  • Journal Title: 最新医学 Volume: 11月号 Pages: 2390-2395
• [Journal Article] 神経疾患と分子マーカー:多発性硬化症 (2010)
  • Author(s): 千原典夫、山村隆
  • Journal Title: Clinical Neuroscience Volume: 28巻12号 Pages: 1396-1399
• [Journal Article] MSの免疫病態のトピックス (2010)
  • Author(s): 冨田敦子、荒浪利昌、山村隆
  • Journal Title: Brain Medical Volume: 22巻 Pages: 25-30
• [Journal Article] Suppression of experimental autoimmune encephalomyelitis by Ghrelin. (2009)
  • Author(s): Theil M.M., S.Miyake, M.Mizuno, C.Tomi, J.L.Croxford, H.Hosoda, J.Theil, S.von Hoersten, H.Yokote, A.Chiba, Y.Lin, S.Oki, T.Akamizu, K.Kangawa, T.Yamamura
  • Journal Title: J.Immunol. 183 Pages: 2859-2866
• [Journal Article] Molecular network of the comprehensive multiple sclerosis brain lesion proteome. (2009)
  • Author(s): Satoh J.I., H.Tabunoki, T.Yamamura
  • Journal Title: Mult.Scler. 15 Pages: 531-541
• [Journal Article] Molecular network of the comprehensive multiple sclerosis brain lesion proteome (2009)
  • Author(s): Satoh JI
  • Journal Title: Mult Scler 15 Pages: 531-541
  • Peer Reviewed
• [Journal Article] Synthetic retinoid AM80 inhibits Th17 cells and ameliorates EAE (2009)
  • Author(s): Klemann C
  • Journal Title: Am J Pathol 174 Pages: 2234-2245
  • Peer Reviewed
• [Journal Article] Suppression of experimental autoimmune encephalomyelitis by Ghrelin (2009)
  • Author(s): Theil, M.M
  • Journal Title: J Immunol 183 Pages: 2859-2866
  • Peer Reviewed
• [Journal Article] Carcinoembryonic antigen-related cell adhesion molecule 1 modulates experimental autoimmune encephalomyelitis via iNKT cell-dependent mechanism (2009)
  • Author(s): Fujita, M.
  • Journal Title: Am J Pathol 175 Pages: 1163-1123
  • Peer Reviewed
• [Journal Article] (2009)
  • Author(s): 荒浪利昌
  • Journal Title: 多発性硬化症.炎症・再生医学事典(松島綱治, 西脇徹編集)(朝倉書店) Pages: 26-218
• [Journal Article] (2009)
  • Author(s): 岡本智子
  • Journal Title: 脱髄性疾患.急性散在性脳脊髄炎.『神経疾患・診療ガイドライン-最新の診療指針-』(編集 鈴木則宏)(総合医学社) Pages: 195-197
• [Journal Article] Molecular network analysis of T-cell transcriptome suggests aberrant regulation of gene expression by NF-κB as a biomarker for relapse of multiple sclerosis. (2008)
  • Author(s): Satoh J-i., T.Misawa, H.Tabunoki, T.Yamamura
  • Journal Title: Dis Markers 25 Pages: 27-35
• [Journal Article] Orphan nuclear receptor NR4A2 expressed in T cells from multiple sclerosis mediates production of inflammatory cytokines. (2008)
  • Author(s): Doi Y., S.Oki, T.Ozawa, H.Hohjoh, S.Miyake, T.Yamamura
  • Journal Title: Proc Natl Acad Sci USA 105 Pages: 8381-8386
• [Journal Article] Th17 cells and autoimmune encephalomyelitis (EAE/MS). (2008)
  • Author(s): Aranami T., T.Yamamura
  • Journal Title: Allergol.Int. 57 Pages: 115-120
  • NAID: 10021246298
• [Journal Article] Molecular network analysis of T-cell transcriptome suggests aberrant regulation of gene expression by NF-_B as a biomarker for relapse of multiple sclerosis (2008)
  • Author(s): Satoh, J-i., T. Misawa, H. Tabunoki, T. Yamamura
  • Journal Title: Dis Markers 25 Pages: 27-35
  • Peer Reviewed
• [Journal Article] Orphan nuclear receptor NR4A2 expressed in T cells from multiple sclerosis mediates production of inflammatory cytokines (2008)
  • Author(s): Doi, Y., S. Oki, T. Ozawa, H. Hohjoh, S. Miyake, T. Yamamura
  • Journal Title: PNAS 105 Pages: 8381-8386
  • Peer Reviewed
• [Journal Article] Treatment of Neuromyelitis Optica : Current Debate (2008)
  • Author(s): Okamoto, T., M. Ogawa, Y. Lin, M. Murata, S. Miyake, T. Yamamura
  • Journal Title: Therapeutic Advances in Neurological Dis orders 1 Pages: 43-52
• [Journal Article] Th17 cells and autoimmune encephalomyelitis (EAE/MS) (2008)
  • Author(s): Aranami, T., T. Yamamura
  • Journal Title: Allergol. Int. 57 Pages: 115-120
  • NAID: 10021246298
• [Journal Article] 話題. ヒトTh17細胞におけるケモカインリセプターの発現 (2008)
  • Author(s): 佐藤和貴郎, 荒浪利昌, 山村隆
  • Journal Title: 臨床免疫・アレルギー科 49 Pages: 89-94
• [Journal Article] Orphan nuclear receptor NR4A2 expressed in T cells from multiple sclerosis mediates production of inflammatory cytokines. (2008)
  • Author(s): Doi, Y.,
  • Journal Title: Proc Natl Acad Sci U S A (in press)
  • Peer Reviewed
• [Journal Article] Cutting Edge.Human Th17 cells are identified as bearing CCR2+CCR5-phenotype. (2007)
  • Author(s): Sato W., T.Aranami, T.Yamamura
  • Journal Title: J.Immunol. 178 Pages: 7525-7529
• [Journal Article] Understanding the behavior of invariant NKT cells in autoimmune diseases. (2007)
  • Author(s): Yamamura T., K.Sakuishi, Zs.Illes, S.Miyake
  • Journal Title: J.Neuroimmunol. 191 Pages: 8-15
• [Journal Article] Human Th17 cells are identified asbearing CCR2+CCR5- phenotype (2007)
  • Author(s): Sato, W., T. Aranami and T. Yamamura
  • Journal Title: J.Immunol 178 Pages: 7525-7529
  • Peer Reviewed
• [Journal Article] TROY and LlNGO-1 expression in astrocytes and macrophages/microglia in MS brains (2007)
  • Author(s): Satoh, J-i.,
  • Journal Title: Neuropathol and Applied Neurobiol 33 Pages: 99-107
  • Peer Reviewed
• [Journal Article] Detection of anti-Nogo receptor autoantibody in the serum of multiple sclerosis and controls. (2007)
  • Author(s): Onoue, H.,
  • Journal Title: Acta Neurologica Scandin 115 Pages: 153-160
  • Peer Reviewed
• [Journal Article] Cutting Edge.Human Th17 cells are identified as bearing CCR2+CCR5-phenotype. (2007)
  • Author(s): Sato, W.,
  • Journal Title: J.Immunol. 178 Pages: 7525-7529
  • Peer Reviewed
• [Journal Article] Aberrant transcriptional regulatory network in T cells of multiplesclerosis. (2007)
  • Author(s): Satoh, J.,
  • Journal Title: Neurosci.Lett 422 Pages: 30-33
  • Peer Reviewed
• [Journal Article] Invariant NKT cells biased for IL-5 production act as crucial regulators of inflammation. (2007)
  • Author(s): Sakuishi, K..,
  • Journal Title: J.Immunol 179 Pages: 3452-3462
  • Peer Reviewed
• [Journal Article] 第二のNKT細胞 (2007)
  • Author(s): 山村 隆
  • Journal Title: 炎症と免疫 15 Pages: 289-291
• [Journal Article] Differential expression of CD11c by peripheral blood NK cells reflects temporal activity of multiple sclerosis. (2006)
  • Author(s): Aranami T., S.Miyake, T.Yamamura
  • Journal Title: J.Immunol. 177 Pages: 5659-5667
• [Journal Article] T cellgene expression profiling identifies distinctsubgroups of Japanese multiple sclerosispatients (2006)
  • Author(s): Satoh, J., M. Nakanishi, F. Koike, H. Onoue, T. Aranami, T. Yamamoto, M. Kawai, S.Kikuchi, K. Nomura, K. Yokoyama, K. Ota, T. Saito, M. Ohta, S. Miyake, T. Kanda, T.Fukazawa and T. Yamamura
  • Journal Title: J. Neuroimmunol 174 Pages: 108-118
  • Peer Reviewed
• [Journal Article] Differential expression of CD11c byperipheral blood NK cells reflects temporalactivity of multiple sclerosis (2006)
  • Author(s): Aranami, T., S. Miyake and T. Yamamura
  • Journal Title: J. Immunol 177 Pages: 5659-5667
  • Peer Reviewed
• [Journal Article] T cell gene expression profiling identifies distinct subgroups of Japanese multiple sclerosis patients (2006)
  • Author(s): Satoh, J-i., M.Nakanishi, F.Koike et al.
  • Journal Title: J. Neuroimmunol. 174 Pages: 108-118
• [Journal Article] Microarrray analysis identifies a set of CXCR3 and CCR2 ligand chemokines as early interferon-β-responsive genes in peripheral blood lymphocytes : an implication for IFN-β related adverse effects in multiple sclerosis (2006)
  • Author(s): Satoh, J-i., Y.Nanri, H.Tabunoki et al.
  • Journal Title: BMC Neurology 6 Pages: 18-34
• [Journal Article] Invariant Vα19i T cells regulate autoimmune inflammation (2006)
  • Author(s): Croxford, J.L., S.Miyake, Y-Y.Huang et al.
  • Journal Title: Nat. Immunol. 7 Pages: 987-94
• [Journal Article] Differential expression of CD11c by peripheral blood NK cells reflects temporal activity of multiple sclerosis (2006)
  • Author(s): Aranami, T., S.Miyakeand, T.Yamamura
  • Journal Title: J. Immunol. 177 Pages: 5659-5667
• [Journal Article] 多発性硬化症の病態 -免疫調節機構の破綻 (2006)
  • Author(s): 荒浪利昌, 山村 隆
  • Journal Title: 医学のあゆみ 219 Pages: 125-128
• [Journal Article] Increase of Ki-67+natural killer cells in multiple sclerosis patients treated with interferon-b combined with low-dose oral steroids.
  • Author(s): Sanvito L., A.Tomita, N.Chihara, T.Okamoto, M.Ogawa, B.Gran, T.Aranami, T.Yamamura
  • Journal Title: J.Neuroimmunol. (in press)
• [Presentation] Progress in pathophysiology in NMO and clinical implications (2011)
  • Author(s): Takashi Yamamura
  • Organizer: The 5th Bochum-Dusseldorf MS symposium
  • Place of Presentation: Bochum, Germany (Bochum conference center)
  • Year and Date: 2011-02-19
• [Presentation] IL-6 signaling promotes anti-aquaporin 4 autoantibody production from plasmablasts in neuromyelitis optica(NMO) (2010)
  • Author(s): Takashi Yamamura
  • Organizer: 2010 Neuromyelitis optica roundtable conference.A rare approach to a rare disease
  • Place of Presentation: Los Angeles, USA(The Beverly Hilton)
  • Year and Date: 2010-11-08
• [Presentation] T cell subsets identified with chemokine receptors in MS (2010)
  • Author(s): Aranami T, Sato, Yamamura T
  • Organizer: MS Immunology Seminar
  • Place of Presentation: Nottingham, England(National College for School Leadership)
  • Year and Date: 2010-10-31
• [Presentation] Keynote lecture.Immunology of NK and NKT ells in MS (2010)
  • Author(s): Takashi Yamamura
  • Organizer: MS Immunology Seminar
  • Place of Presentation: Nottingham, England(National College for School Leadership)
  • Year and Date: 2010-10-31
• [Presentation] Auto-reactive anti-aquaporin 4 antibodies are secreted from peripheral plasma cell-like B cells in neuromyelitis optics (2010)
  • Author(s): Chihara N, Aranami T, Sato W, Miyazaki Y, Miyake S, Okamoto T, Ogawa M, Yamamura T
  • Organizer: Kobe : 14th Internatinal Congress of Immunology 2010
  • Place of Presentation: Kobe(神戸国際会議場)
  • Year and Date: 2010-08-23
• [Presentation] CCR2+ CCR5+ CD4+ T cells enriched in cerebrospinal fluid of relapsing multiple sclerosis patients strongly express matrix metalloproteinase-9 and osteopontin (2010)
  • Author(s): Wakiro Sato, Atsuko Tomita, Youwei Lin, Masafumi Ogawa, Tomoko Okamoto, Miho Murata, Toshimasa Aranami, Takashi Yamamura
  • Organizer: Kobe : 14th Internatinal Congress of Immunology 2010
  • Place of Presentation: Kobe(神戸国際会議場)
  • Year and Date: 2010-08-23
• [Presentation] Plasma cell-like B cells produce aquaporin 4 autoantibody in neuromyelitis optica (2010)
  • Author(s): Chihara N, Aranami T, Sato W, Miyazaki Y, Miyake S, Okamoto T, Ogawa M, Yamamura T
  • Organizer: Kyoto : Neuroimmunology Kyoto Conference 2010
  • Place of Presentation: Kyoto(京都ガーデンパレスホテル)
  • Year and Date: 2010-08-21
• [Presentation] 多発性硬化症の基礎と臨床.レビュートーク「神経免疫と臨床免疫:現在の到達点」 (2010)
  • Author(s): 山村隆
  • Organizer: 第22回日本神経免疫学会
  • Place of Presentation: 東京、日経ホール
  • Year and Date: 2010-03-17
• [Presentation] 免疫性神経疾患の治療戦略 (2009)
  • Author(s): 山村隆
  • Organizer: 日本レチノイド研究会第20回学術集会「AM80の開発から臨床まで」
  • Place of Presentation: 東京、慈恵医大
  • Year and Date: 2009-11-21
• [Presentation] Treatment of NMO and MS : Can we use same drugs? (2009)
  • Author(s): 山村隆
  • Organizer: International Symposium New Aspects of Neuromyelitis Optica(NMO)
  • Place of Presentation: 淡路島、Awaji Yumebutai kokusaikaigijyou
  • Year and Date: 2009-10-03
• [Presentation] Opening lecture-Multiple sclerosis research in Japan : past, present and future (2009)
  • Author(s): 山村隆
  • Organizer: Second German-Japanese Neuroimmunology Symposium
  • Place of Presentation: Eibsee、Eibsee Hotel, Germany
  • Year and Date: 2009-07-09
• [Presentation] Orphan nuclear receptor NR4A2 and inflammatory cascade of MS/EAE. Plenary Session. Effector Mechanisms (2008)
  • Author(s): Yamamura T
  • Organizer: IXth International Congress of Neuroimmunology, Sheraton Fort Worth Hotel and Spa, Fort Worth
  • Place of Presentation: Texas, USA
  • Year and Date: 2008-10-29
• [Presentation] Orphan nuclear receptorNR4A2 and inflammatory cascade ofMS/EAE (2008)
  • Author(s): Yamamura, T
  • Organizer: IXthInternational Congress ofNeuroimmunology
  • Place of Presentation: Fort Worth, Texas, USA
  • Year and Date: 2008-10-29
• [Presentation] Orphan nuclear receptor NR4A2 and inflammatory cascade of MS/EAE (2008)
  • Author(s): Yamamura, T
  • Organizer: IXth International Congress of Neuroimmunology
  • Place of Presentation: Fort Worth, Texas, USA
  • Year and Date: 2008-10-29
• [Presentation] 多発性硬化症の病態解析から治療標的の同定へ (2008)
  • Author(s): 山村隆
  • Organizer: 日本臨床免疫学会
  • Place of Presentation: 東京
  • Year and Date: 2008-10-18
• [Presentation] 多発性硬化症の分子病態と治療標的 (2008)
  • Author(s): 山村隆
  • Organizer: 日本臨床分子医学会
  • Place of Presentation: 神戸
  • Year and Date: 2008-07-24
• [Presentation] 免疫疾患としての多発性硬化症 (2008)
  • Author(s): 山村隆
  • Organizer: 日本神経学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2008-05-16
• [Presentation] 特別講演 V. 免疫制御システムと神経免疫疾患 (2008)
  • Author(s): 山村隆
  • Organizer: 第20回日本神経免疫学会
  • Place of Presentation: 新潟
  • Year and Date: 2008-04-17
• [Presentation] 特別講演V. 免疫制御システムと神経免疫疾患 (2008)
  • Author(s): 山村隆
  • Organizer: 第20回日本神経免疫学会
  • Place of Presentation: 新潟
  • Year and Date: 2008-04-17
• [Presentation] Regulatory networks inthe immune system (2007)
  • Author(s): Yamamura, T
  • Organizer: International Symposium on MultipleSclerosis-advances in basic researchand immunotherapy- Im Horsaalzentrumdes Katholischen Klinikums Bochum
  • Place of Presentation: Bochum, Germany
  • Year and Date: 2007-12-08
• [Presentation] Regulatory networks in the immune system (2007)
  • Author(s): Yamamura, T.
  • Organizer: lntemational Symposium on Multiple Sclerosis-advances in basic research and immunotherapy.lm Horsaalzentrum des KatholischenKlinikums Bochum
  • Place of Presentation: Bochum, Germany
  • Year and Date: 2007-12-08
• [Presentation] The role of IL-5producing NK and NKT cells in the humanimmune homeostasis (2007)
  • Author(s): Yamamura, T
  • Organizer: Symposium 8. Human immunity and immuneintervention. The 35^<th> Annual Meetingof the Japanese Society of Immunology
  • Place of Presentation: Tokyo
  • Year and Date: 2007-11-21
• [Presentation] The role of IL-5 producing NK and NKT cells in the human immune homeostasis. (2007)
  • Author(s): Yamamura, T.
  • Organizer: Symposium 8. Human immunity and immuneintervention.The 35th Annual Meeting of the Japanese Society of Immunology
  • Place of Presentation: Tokyo
  • Year and Date: 2007-11-21
• [Presentation] Microarray analysisidentifies distinct subgroups ofJapanese multiple sclerosis patients.Panel Session 5 Advancing MicroarrayTechnology in GeriatricPsychoneuropharmacology (2007)
  • Author(s): Yamamura, T
  • Organizer: 7^<th> Internatonal College of GeriatricPsychoneuropharmacology(ICGP)
  • Place of Presentation: San Diego, USA
  • Year and Date: 2007-11-01
• [Presentation] Microarray analysis identifies distinct subgroups of Japanesemultiple sclerosis patients-Panel Session 5 Advancing Microarray Technology in Geriatric Psychoneuropharmacology, (2007)
  • Author(s): Yamamura, T.
  • Organizer: 7th Internatonal College of Geriatric Psychoneuropharmacology(ICGP),
  • Place of Presentation: San Diego, USA
  • Year and Date: 2007-11-01
• [Presentation] 多発性硬化症の臨床免疫学 (2007)
  • Author(s): 山村隆
  • Organizer: Plenary lecture 3.第35回日本臨床免疫学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2007-10-20
• [Presentation] 多発性硬化症の臨床免疫学 (2007)
  • Author(s): 山村 隆
  • Organizer: Plenary lecture 3.第35回日本臨床免疫学会総会,
  • Place of Presentation: 大阪,
  • Year and Date: 2007-10-20
• [Presentation] Regulation ofAutoimmune Diseases by Invariant Tcells(NKT cells and MAIT cells) (2007)
  • Author(s): Yamamura, T
  • Organizer: The 20th NAITO Conferenceon InnateImmunity in Medicine andBiology[III]
  • Place of Presentation: Shonan Village Center
  • Year and Date: 2007-10-12
• [Presentation] Regulation of Autoimmune Diseases by Invariant T-cells(NKT cells and MAIT cells). (2007)
  • Author(s): Yamamura, T.
  • Organizer: The 20th NAITO Conference on lnnate lmmunity in Medicine and Biology[III]
  • Place of Presentation: Shonan Village Center
  • Year and Date: 2007-10-12
• [Presentation] Regulatory roles ofinvariant T cells in autoimmuneinflammation (2007)
  • Author(s): Yamamura, T
  • Organizer: MainSymposium. Mechanisms of inflammatorydiseases. 13^<th> International Congressof Immunology
  • Place of Presentation: Rio, Brazil
  • Year and Date: 2007-08-22
• [Presentation] Regulatory roles of invariant T cells in autoimmune inflammation (2007)
  • Author(s): Yamamura, T.
  • Organizer: Main Symposium.Mechanisms of inflammatory diseases.13th lnternational Congress of Immunology
  • Place of Presentation: Rio, Brazil
  • Year and Date: 2007-08-22
• [Presentation] NK cells and multiplesclerosis : Do the innate cells mirror temporal disease activity? (2007)
  • Author(s): Yamamura, T
  • Organizer: Pecs -Tubingen NeuroimmunologyDays 2007
  • Place of Presentation: Pecs
  • Year and Date: 2007-04-13
• [Presentation] NK cells and multiple sclerosis: Do the innate cells mirror temporal disease activity? (2007)
  • Author(s): Yamamura, T.
  • Organizer: Pecs-Tubingen Neuroimmunology Days 2007
  • Place of Presentation: Pecs
  • Year and Date: 2007-04-13
• [Book] The Immune System Series "Results and Problems in Cell Differentiation"(Role of NK cells and NKT cells in multiple sclerosis. Molecular Basis of Multiple Sclerosis)(Roland Martin, and Andreas Lutterotti, ed 51 査読あり) (2009)
  • Author(s): Sakuishi K., S.Miyake, Yamamura T.
  • Publisher: Springer-Verlag, Heidelberg
• [Book] Role of NK cells and NKT cells in multiple sclerosis.Molecular Basis of Multiple Sclerosis.The Immune System Series "Results and Problems in Cell Differentiation" (2009)
  • Author(s): Sakuishi K
  • Publisher: Springer-Verlag(Epub ahead of print)
• [Book] Results Probl Cell Differ (2009)
  • Author(s): Sakuishi K, Miyake S, Yamamura T
  • Publisher: Role of NK Cells and Invariant NKTCells in Multiple Sclerosis
• [Book] 多発性硬化症の診断と治療 (2008)
  • Author(s): 荒浪利昌, 山村隆
  • Total Pages: 6
  • Publisher: 多発性硬化症の疾患活動性のマーカーとそのモニタリング
• [Book] Immune Regulation and Immunotherapy in Autoimmune Disease.(Editor Jingwu Zhang)(Invariant NKT cells and immune regulation in multiple sclerosis 査読なし) (2007)
  • Author(s): Yamamura T
  • Publisher: Springer
• [Book] unraveling the complexity (2007)
  • Author(s): Miyake S, Yamamura T
  • Total Pages: 314
  • Publisher: NKT cells and autoimmune diseases
• [Book] Current Topics in Microbiology and lmmunology (2007)
  • Author(s): Miyake, S.
  • Total Pages: 17
  • Publisher: Springer-Verlag
• [Book] In Immune Regulation and lmmunotherapy in Aufoimmune Disease (2007)
  • Author(s): Yamamura, T.
  • Total Pages: 13
  • Publisher: Springer
• [Book] lmmune Regulation and Immunotherapy in Aufoimmune Disease (2007)
  • Author(s): Yamamura, T
  • Publisher: Springer
• [Remarks] ホームページ等
  • URL: http://www.ncnp.go.jp/nin/guide/r_men/yamamura.html
• [Remarks]
  • URL: http://www.ncnp.go.jp/nin/guide/r_men/yamamura-e.html
• [Remarks]
  • URL: http://www.ncnp.go.jp/pdf/nin_topics_110324.pdf
• [Remarks]
  • URL: http://www.ncnp.go.jp/pdf/nin_report_e.pdf