Functional roles of synapse remodeling
Project/Area Number |
18200025
|
Research Category |
Grant-in-Aid for Scientific Research (A)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Nerve anatomy/Neuropathology
|
Research Institution | The University of Tokyo (2007-2008) Tokyo Medical and Dental University (2006) |
Principal Investigator |
OKABE Shigeo The University of Tokyo, 大学院・医学系研究科, 教授 (60204012)
|
Co-Investigator(Kenkyū-buntansha) |
KONDO Satoru 東京大学, 大学院・医学系研究科, 講師 (20301757)
|
Project Period (FY) |
2006 – 2008
|
Project Status |
Completed (Fiscal Year 2008)
|
Budget Amount *help |
¥46,280,000 (Direct Cost: ¥35,600,000、Indirect Cost: ¥10,680,000)
Fiscal Year 2008: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2007: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2006: ¥27,300,000 (Direct Cost: ¥21,000,000、Indirect Cost: ¥6,300,000)
|
Keywords | シナプス / グルタミン酸受容体 / 可塑性 / 蛍光顕微鏡 / 神経培養 / シナプス後肥厚部 / シナプス可塑性 / 蛍光顕微鏡法 |
Research Abstract |
シナプス分子動態の最先端顕微鏡技術による解析を、遺伝子改変動物の作成などの研究手法と融合することで、組織レベルでの神経回路の機能変化とシナプスでの分子集積の間の関連を明らかにする事を目的として研究を行い、シナプスに集積する分子がそれぞれの分子種特異的な動態を持つこと、カルシウムにより制御されるリン酸化酵素CaMKIIαの活性化が神経回路の機能的変化に必須であることを見出した。
|
Report
(4 results)
Research Products
(100 results)
-
[Journal Article] tropomyosin is essential for aquaporin-2 trafficking2008
Author(s)
Noda, Y., Horikawa, S, Kanda, E., Yamashita, M., Meng, H., Eto, K., Kuwahara, M., Hirai, K., Pack, C., Kinjo, M., Okabe, S., and S. Sasaki
-
Journal Title
Journal of Cell Biology 182
Pages: 587-601
Related Report
Peer Reviewed
-
[Journal Article] Personality in schizophrenia assessed with the Temperament and Character Inventory (TCI)2008
Author(s)
Hori, H., Noguchi, H., Hashimoto, R., Nakabayashi, T., Saitoh, O., Murray, R. M., Okabe, S., and H. Kunugi
-
Journal Title
Psychiatry Research 160
Pages: 175-183
Related Report
Peer Reviewed
-
[Journal Article] Schizotypal traits in healthy women predict prefrontal activation patterns during a verbal fluency task2008
Author(s)
Hori, H., Nagamine, M., Soshi, T., Okabe, S., Kim, Y., and H. Kunugi
-
Journal Title
A near-infrared spectroscopy study Neuropsychobiology 57
Pages: 61-69
Related Report
Peer Reviewed
-
[Journal Article] Regulation of dendritic spine morphology by an NMDA receptor-associated Rho GTPase-activating protein2008
Author(s)
Nakazawa, T., Kuriu, T., Tezuka, T., Umemori, H., Okabe, S., and Yamamoto, T.
-
Journal Title
p250GAP Journal of Neurochemistry 105
Pages: 1384-1393
Related Report
Peer Reviewed
-
[Journal Article] Co-localization of a novel transcriptional repressor simiRP58 with RP582008
Author(s)
Takahashi, A., Hirai, S., Ohtaka-Maruyama, C., Miwa, A., Hata, Y., Okabe, S., H. Okado
-
Journal Title
Biochemical and Biophysical Research Communications 368
Pages: 637-642
Related Report
Peer Reviewed
-
-
-
[Journal Article] Co-Localization of a novel transcriptional repressor SimiRP58 with RP582008
Author(s)
Takahashi, A., Hirai, S., Ohtaka-Maruyama, C., Miwa, A., Hata, Y., Okabe, S. and H. Okado
-
Journal Title
Biochemical and Biophysical Research Communications 368
Pages: 637-642
Related Report
Peer Reviewed
-
[Journal Article] Regtulation of dendritic spine morphology by an NMDA receptor-associated Rho GTPase-activating protein, p250GAP2008
Author(s)
Nakazawa, T., Kuriu, T., Tezuka, T., Umemori, H., Okabe, S., and Yamamot, T.
-
Journal Title
Journal of Neurochemistry 105
Pages: 1384-1393
Related Report
Peer Reviewed
-
[Journal Article] Schizotypal traits in healty women predict prefrontal activation patterns during a verbal fluency task: A near-infraed spectroscopy study2008
Author(s)
Hori, H., Nagamine, M., Soshi, T., Okabe, S., Kim, Y., and H. Kunugi
-
Journal Title
Neuropsychobiology 57
Pages: 61-69
Related Report
Peer Reviewed
-
[Journal Article] Reciprocal interaction with G-actin and tropomyosin is essential for aquaporin-2 trafficking2008
Author(s)
Noda, Y., Horikawa, S., Kanda, E., Yamashita, M., Meng, H., Eto, K., Kuwahara, M., Hirai, K., Pack, C., Kinjo, M., 0abe, S., and S. Sasaki
-
Journal Title
Journal of Cell Biology 182
Pages: 587-601
Related Report
Peer Reviewed
-
[Journal Article] Regulation of dendriti spine morhology by an NMDA receptor-associated Rho GTPase-activating protein,p250GAP2008
Author(s)
Nakazawa, T., Kuriu, T., Tezuka, T., Umemori, H., Okabe, S., and Yamamoto.T.
-
Journal Title
Journal of Neurochemistry (in press)(掲載確定)
Related Report
Peer Reviewed
-
[Journal Article] Co-10calization of a novel transcriptional repressor simiRP58 with RP582008
Author(s)
Takahashi, A., Hirai, S., Ohtaka-Maruyama, C, , Miwa, A., Hata, Y., Okabe.S. and H.Okado
-
Journal Title
Biochemical and Biophysical Research Communications 368
Pages: 637-642
Related Report
Peer Reviewed
-
-
-
[Journal Article] The Sec1/Munc18 family protein, VPS-45, is required for RAB-5-dependent endocytic trafficking in C. elegans2007
Author(s)
Gengyo-Ando, K., Kuroyanagi, H., Kobayashi, T., Murate, M., Fujimoto, K., Okabe, S., S. Mitani
-
Journal Title
EMBO Reports 8
Pages: 152-157
Related Report
Peer Reviewed
-
-
-
[Journal Article] The Sec1/Munc 18 family protein,VPS-45,is required for RAB-5-dependent endocytictrafHcking in C.elegans2007
Author(s)
Gengyo-Ando, K., Kuroyanagi, H., Kobayashi, T., Murate, M., Fujimoto, K. Okabe.S. and S.Mitani
-
Journal Title
EMBO Reports 8
Pages: 152-157
Related Report
Peer Reviewed
-
-
-
[Journal Article] The Sec1/Munc18 family protein, VPS-45,is required for RAB-5-dependent endocytic trafficking in C.elegans2007
Author(s)
Gengyo-Ando, K., Kuroyanagi, H., Kobayashi, T., Murate, M., Fujimoto, K., Okabe, S., S.Mitani
-
Journal Title
EMBO Reports 8
Pages: 152-157
Related Report
-
[Journal Article] Myosin-Va facilitates the accumulation of mRNA/protein complex in dendritic spines2006
Author(s)
Yoshimura, A., Fujii, R., Watanabe, Y., Okabe, S., Fukui, K., and T. Takumi
-
Journal Title
Current Biology 16
Pages: 2345-2351
Related Report
Peer Reviewed
-
[Journal Article] Antipsychotic medication and cognitive function in schizophrenia2006
Author(s)
Hori, H., Noguchi, H., Hashimoto, R., Nakabayashi, T., Omori, M., Takahashi, S., Tsukue, R., Anami, K., Hirabayashi, N., Harada, S., Saito, O., Iwase, M., Kajimoto, O., Takeda, M., Okabe, S., H. Kunugi
-
Journal Title
Schizophrenia Research 86
Pages: 138-146
Related Report
Peer Reviewed
-
-
[Journal Article] Telencephalin slows spine maturation2006
Author(s)
Matsuno, H., Okabe, S., Mishina, M., Yanagida, T., Mori, K., and Y. Yoshihara
-
Journal Title
Journal of Neuroscience 26
Pages: 1776-1786
Related Report
Peer Reviewed
-
-
[Journal Article] Antipsychotic medication and cognitive function in schizophrenia.2006
Author(s)
Hori, H., Noguchi, H., Hashimoto, R., Nakabayashi, T., Omori, M., Takahashi, S., Tsukue, R., Anami, K., Hirabayashi, N., Harada, S., Saito, O., Iwase, M., Kajimoto, O., Takeda, M., Okabe, S., H.Kunugi
-
Journal Title
Schizophrenia Research 86
Pages: 138-146
Related Report
-
[Journal Article] Myosin-Va facilitates the accumulation of mRNA/protein complex in dendritic spines.2006
Author(s)
Yoshimura, A., Fujii, R., Watanabe, Y., Okabe, S., Fukui, K., T.Takumi
-
Journal Title
Current Biology 16
Pages: 2345-2351
Related Report
-
[Journal Article] Kinase-dead knock-in mouse reveals an essential role of CaMKIIα kinase activity in dendritic spine enlargement, LTP and learning
Author(s)
Yamagata, Y., Kobayashi, S., Umeda, T., Inoue, A., Sakagami, H., Fukaya, M., Watanabe, M., Hatanaka, N., Totsuka, M., Yagi, T., Obata, K., Imoto, K., Yanagawa, Y., Manabe, T., S. Okabe
-
Journal Title
Journal of Neuroscience (in press)
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-