Pursuit for regulatory mechanisms at inhibitory synapses and therapeutic basis

• Project/Area Number: 18200026
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: Tokushima Bunri University
• Principal Investigator: KONISHI Shiro Tokushima Bunri University, 香川薬学部, 教授 (20014277)
• Co-Investigator(Kenkyū-buntansha): TOMINAGA Takashi 徳島文理大学, 香川薬学部, 准教授 (20344046) ; SONG Si-young 徳島文理大学, 香川薬学部, 教授 (00399693) ; SAITOW Fumihito 日本医科大学, 医学部, 准教授 (20360175) ; 栗生 俊彦 徳島文理大学, 香川薬学部, 助教 (10401374)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥48,620,000 (Direct Cost: ¥37,400,000、Indirect Cost: ¥11,220,000); Fiscal Year 2008: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000); Fiscal Year 2007: ¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000); Fiscal Year 2006: ¥20,280,000 (Direct Cost: ¥15,600,000、Indirect Cost: ¥4,680,000)
• Keywords: 神経科学 / 脳 / 神経 / 生理学 / 薬学 / 薬理学 / 脳・神経 / GABAシナプス / 抑制 / 脳神経疾患

Research Abstract

脳内の抑制性GABA シナプス周辺における神経伝達の制御機構について研究を進めた。とくに小脳GABA シナプス周辺には、3 種類に大別できる新規のシナプス制御機構が存在することを発見し、その細胞・分子機構の一部を明らかにした。このようなシナプス機構は、精神神経疾患を克服するための新たな作用原理に基づく薬物治療の標的となることが示唆された。

Research Products

• [Journal Article] Neuron-Glia Communication: Involvements of Glial Cells in Synaptic Transmission (2007)
  • Author(s): Konishi S., Ono Y., Zhu X.-M., Kuriu T., Tominaga T. & Saitow F.
  • Journal Title: Trends in Glia Research - Basic and Applied (edit. By S. Thameem and Eng-Ang Ling), Research Signpost, Kerala Pages: 139-152
• [Journal Article] Olfactory information converges in the amygdaloid cortex via the iriform and entorhnal cortices observations in the guinea pig isolatedhole-brain prearation (2007)
  • Author(s): Kajiwara, R., Tominaga, T., and Takashima, I.
  • Journal Title: Eur J Neurosci 25 Pages: 3648-3658
• [Journal Article] Neuronal glutamate transporter EAAT4 controls climbingfiber mediated presynaptic inhibition of GABAergic transmission at cerebellarinterneuron-Purkinje cell synapses (2007)
  • Author(s): Satake, S., Song, S.y., E.A., and Konishi, S, and Imoto, K.
  • Journal Title: Neurosci Res 55
• [Journal Article] Mechanisms underlying P2Y purinoceptor-mediated long-termenhancement of GABAergic transmission on cerebellar Purkinje cells (2007)
  • Author(s): Ono, Y., Tominaga, T., Saitow., and Konishi, S.
  • Journal Title: J Physiol Sci 57
  • NAID: 130007038567
• [Journal Article] Mechanisms op P2Y punnoceptor-melated long-term enancement of inhibitory transmission examined by multiple-probability fluctuation analsls at cerebellar GABAeric synases (2007)
  • Author(s): Ono, Y., Zhu XM., Tominaga, T., Saitow, F., and Konishi, S.
  • Journal Title: Neurosci Res 55
• [Journal Article] Characterization of AMPA receptors targeted by the climbing fiber transmitter mediating presynaptic inhibition of GABAergic transmission at cerebellar interneuron-Purkinje cell synapses (2006)
  • Author(s): Satake S., Song S.-Y., Cao Q., Satoh H., Rusakov D.A., Yanagawa Y., Ling E.-A., Imoto K. & Konishi S.
  • Journal Title: Journal of Neuroscience 26 Pages: 2278-2289
• [Journal Article] Characterization of AMPA receptors targeted by the climbing fiber transmitter mediating presynaptic inhibition of GABAergic transmission at cerebellar interneuron-Purkinje cell synapses. (2006)
  • Author(s): Satake, S, song, S.Y, Cao, Q, Satoh, H, Rusakov, D.A, Yanagawa, Y, Ling, E.A, Imoto, K, Konishi, S.
  • Journal Title: J Neurosci 26 Pages: 2278-2289
• [Journal Article] Distribution and pharmacological characterization of primate NK-1 and NK-3 tachykinin receptors in the central nervous system of the rhesus monkey. (2006)
  • Author(s): Nagano, M, Saitow, F, Haneda, E, Konishi, S, Hayashi, M, Suzuki, H.
  • Journal Title: Br J Pharmacol 147 Pages: 316-323
• [Journal Article] Differential control of postsynaptic density scaffolds viaactin-dependent and -independent mechanisms. (2006)
  • Author(s): Kuriu, T, Inoue, A, Bito, H, Sobue, K, Okabe, S.
  • Journal Title: J Neurosci 26 Pages: 7693-7706
• [Presentation] Reciprocal interactions between excitatory and inhibitory synapses in the cerebellar cortex (2008)
  • Author(s): Konishi, S.
  • Organizer: Symposium on "Modulation of Neurotransmission by Diffusible Factors" organized by Kano M., 85th Annual Meeting of the PhysiologicalSociety of Japan
  • Place of Presentation: Tokyo
• [Presentation] Crosstalk between GABAB receptors and group I metabotropic glutamate receptors in mouse dorsal root ganglion neurons (2008)
  • Author(s): Masuoka, T., Tokumaru, K., Kuriu, T., Konishi, S.
  • Organizer: Soc. Neurosci. Abstr. 38: 823.10
• [Presentation] マウス後根神経節細胞における機能的グループI 代謝型グルタミン酸受容体の存在 (2008)
  • Author(s): 益岡 尚由、得丸 慶子、小西 史朗
  • Organizer: 第31 回日本神経科学大会
  • Place of Presentation: 東京
• [Presentation] Presence of functional group I metabotropic glutamate receptors in mouse dorsal root ganglion neurons (2008)
  • Author(s): Masuoka T, Tokumaru K and Konishi S.
  • Organizer: Neuroscience Research 61, S147
• [Presentation] Crosstalk between GABA_B receptors and group I metabotropic glutamate receptors in mouse dorsal root ganglion neurons (2008)
  • Author(s): Masuoka, T., Tokumaru, K., Kuriu, T., Konishi. S.
  • Organizer: Society for Neuroscience
  • Place of Presentation: Washington, DC
• [Presentation] マウス後根神経節細胞における機能的グループI代謝型グルタミン酸受容体の存在 (2008)
  • Author(s): 益岡尚由, 得丸慶子, 小西史朗
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
• [Presentation] Mechanisms underlying P2Y purinoceptor-mediated long-term enhancement of GABAergic transmission on cerebellar Purkinje cells. J Physiol Sci 57, S230 (2007)
  • Author(s): Ono, Y., Tominaga, T., Saitow, F., and Konishi, S.
  • Organizer: 84th Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: Osaka
• [Presentation] Mechanisms of P2Y purinoceptor-mediated long-term enhancement of inhibitory transmission examined by multiple-probability fluctuation analysis at cerebellar GABAergic synapses (2006)
  • Author(s): Ono, Y., Zhu, X., Tominaga, T., Saitow, F., and Konishi, S.
  • Organizer: 29th Annual Meeting of the Japan Neuroscience Society (Neuroscience 2006). Neuroscience Research 55, S51
  • Place of Presentation: Kyoto
• [Presentation] Neuronal glutamate transporter EAAT4 controls climbing fiber-mediated presynaptic inhibition of GABAergic transmission at cerebellar interneuron-Purkinje cell synapses (2006)
  • Author(s): Satake S, Song SY, Konishi S and Imoto K
  • Organizer: Neuroscience Research 55, S83
• [Presentation] 抑制性GABA 作動性伝達のシナプス間クロストークによる制御機構 (2006)
  • Author(s): 小西史朗
  • Organizer: 第33 回日本神経内分泌学会学術集会招待教育講演
  • Place of Presentation: 横浜
• [Presentation] Activation of P2Y purinoceptors enhances single-channel conductance of GABAA receptors at cerebellar inhibitory synapses (2006)
  • Author(s): Ono, Y., Zhu, X.-., Tominaga, T., Saitow, F., and Konishi, S.
  • Organizer: Soc. Neurosci. Abstr. 36: 328.14
• [Book] Neuron-Glia Communication:Involvements of Glial Cells Synaptic Transmission. In Trends in Glia Research-Basic and Applied, edit. By S. Thameem and Eng-Ang Ling (2007)
  • Author(s): Konishi S., Ono Y., Zhu X.-M., Kuriu T., Tominaga T. & Saitow F.
  • Publisher: Research Signpost