Multi-dimensional analysis of neural circuits controlling saccadic eye movements and visual attention

• Project/Area Number: 18200027
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurophysiology and muscle physiology
• Research Institution: National Institute for Physiological Sciences
• Principal Investigator: ISA Tadashi National Institute for Physiological Sciences, 発達生理学研究系, 教授 (20212805)
• Co-Investigator(Kenkyū-buntansha): KANEDA Katsuyuki 生理学研究所, 発達生理学研究系, 助教 (30421366)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥49,010,000 (Direct Cost: ¥37,700,000、Indirect Cost: ¥11,310,000); Fiscal Year 2008: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000); Fiscal Year 2007: ¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000); Fiscal Year 2006: ¥22,620,000 (Direct Cost: ¥17,400,000、Indirect Cost: ¥5,220,000)
• Keywords: 上丘 / サッケード / スライス / フィールド電位 / ホールセル記録 / 局所回路 / マウス / 黒質 / 眼球運動 / 局所神経回路 / サッケード運動 / 注意 / 周辺抑制 / バースト発火 / 遺伝子改変マウス

Research Abstract

衝動性眼球運動(サッケード)は、我々が視野内の視覚対象に視線を注視させるために行う素早い眼球運動のことである。サッケードの生成には中脳の上丘が脳幹レベルの中枢として重要な役割を果たす。上丘からの出力は主にサッケードのべクトルを符号し、その信号は脳幹網様体にある神経回路を経て速度信号に変換されて運動ニューロンを活性化する。一方で、前頭眼野や頭頂連合野などの大脳皮質領域は上丘の活動を状況依存的に制御している。本研究課題では、マウスの上丘の脳スライス標本を用いて上丘の局所神経回路での情報処理の原理を明らかにすることを目的とし、浅層と中間層の間の相互作用、両層の中での水平性結合の機能および黒質網様部から中間層へのGABA作動性入力および脚橋被蓋核から中間層へのコリン作動性入力の作用を明らかにした。

Research Products

• [Journal Article] Compensatory changes at the cerebral cortical level after spinal cord injury. (2009)
  • Author(s): Nishimura Y, Isa T
  • Journal Title: The Neuroscientist (in press)
  • Peer Reviewed
• [Journal Article] A common subcortical oscillatory network contributes to recovery after spinal cord injury. (2009)
  • Author(s): Nishimura Y, Morichika Y, Isa T
  • Journal Title: Brain 132 Pages: 709-721
  • Peer Reviewed
• [Journal Article] A subcortial oscillatory network contributes to recovery of hand dexterity after spinal cord injury (2009)
  • Author(s): Nishimura Y, Morichika Y, Isa T
  • Journal Title: Brain (In press)
  • Peer Reviewed
• [Journal Article] Introduction (2008)
  • Author(s): Isa T, Schwartz AB
  • Journal Title: Current Opinion in Neurobiology
  • Peer Reviewed
• [Journal Article] Nigral inhibition of GABAergic neurons in mouse superior colliculus. (2008)
  • Author(s): Kaneda K, Isa K, Yanagawa Y, Isa T
  • Journal Title: Journal of Neuroscience 28 Pages: 11071-11078
  • Peer Reviewed
• [Journal Article] Striate cortical lesions affect deliberate decision and control of saccade : implication for blindsight. (2008)
  • Author(s): Yoshida M, Takaura K, Kato R, Ikeda T, Isa T
  • Journal Title: Journal of Neuroscience 28 Pages: 10517-10530
  • Peer Reviewed
• [Journal Article] Cholinergic responses in crossed tecto-reticular neurons of rat superior colliculus. (2008)
  • Author(s): Sooksawate T, Isa K, Isa T
  • Journal Title: Journal of Neurophysiology 100 Pages: 2702-2711
  • Peer Reviewed
• [Journal Article] Spatio-temporal profiles of field potentials in mouse superior colliculus analyzed by multichannel recording. (2008)
  • Author(s): Phongphanphanee P, Kaneda K, Isa T
  • Journal Title: Journal of Neuroscience 28 Pages: 9309-9318
  • Peer Reviewed
• [Journal Article] Dendritic Ih ensures high-fidelity spike responses of motion sensitive neurons in rat superior colliculus. (2008)
  • Author(s): Endo T, Tarusawa E, Notomi T, Kaneda K, Hirabayashi M, Shigemoto R, Isa T
  • Journal Title: Journal of Neurophysiology 99 Pages: 2066-2076
  • Peer Reviewed
• [Journal Article] Regulation of burst activity through pre- and postsynaptic GABAB receptors in mouse superior colliculus. (2008)
  • Author(s): Kaneda K, Phongphanphanee P, Katoh T, Isa K, Yanagawa Y, Obata K, Isa T
  • Journal Title: Journal of Neuroscience 28 Pages: 816-827
  • Peer Reviewed
• [Journal Article] Spatio-temporal profiles of field potentials in mouse superior colliculus (2008)
  • Author(s): Phongphanphanee P, Isa K, Isa T
  • Journal Title: Journal of Neuroscience 28 Pages: 9309-9318
  • Peer Reviewed
• [Journal Article] Cholinergic responses in crossed tecto-reticular neurons of rat superior colliculus (2008)
  • Author(s): Sooksawate T, Isa, K, Isa T
  • Journal Title: Journal of Neurophysiology 100 Pages: 2702-2711
  • Peer Reviewed
• [Journal Article] Striate cortical lesions affect deliberate decision and control of saccade : Implication for blindsight (2008)
  • Author(s): Yoshida M, Takaura K, Kato R, Ikeda T, Isa T
  • Journal Title: Journal of Neuroscience 28 Pages: 10541-10548
  • Peer Reviewed
• [Journal Article] Nigral inhibition of GABAergic neurons in mouse superior colliculus (2008)
  • Author(s): Kaneda K, Isa K, Yanagawa Y, Isa T
  • Journal Title: Journal of Neuroscience 28 Pages: 11071-11078
  • Peer Reviewed
• [Journal Article] Regulation of burst activity through pre-and postsynaptic GABA_B receptors in mouse superior colliculus (2008)
  • Author(s): Kaneda K, Phongphanphanee P, Katoh T, Isa K, Yanagawa Y, Obata K, Isa T
  • Journal Title: Journal of Neuroscience 28 Pages: 816-827
  • Peer Reviewed
• [Journal Article] Dendritic Ih ensures high-fidelity spike responses of motion sensitive neurons in rat superior colliculus (2008)
  • Author(s): Endo T, Tarusawa E, Notomi T, Kaneda K, Hirabayashi M, Shigemoto R, Isa T
  • Journal Title: Journal of Neurophysiology in press
  • Peer Reviewed
• [Journal Article] Direct and indirect cortico-motoneuronal pathways and control of hand/arm movements. (2007)
  • Author(s): Isa, T., Ohki, Y., Alstermark, B., Pettersson, L-G., Sasaki, S
  • Journal Title: Physiology 22 Pages: 145-152
  • Peer Reviewed
• [Journal Article] Skilled digit movements in feline and primate - descending control and motor recovery after spinal cord injuries. (2007)
  • Author(s): Pettersson L.-G.., Alstermark, B., Blagovechtchenski, E., Isa, T., Sasaski, S
  • Journal Title: Acta Physiol. Scand. 189 Pages: 141-154
  • Peer Reviewed
• [Journal Article] The C3-C4 propriospinal system in the cat and monkey ; a spinal premotoneuronal centre for voluntary motor control. (2007)
  • Author(s): Alstermark, B. Isa, T., Pettersson, L-G., Sasaki, S
  • Journal Title: Acta.Physiol. Scand. 189 Pages: 123-140
  • Peer Reviewed
• [Journal Article] Time-dependent central compensatory mechanism of finger dexterity after spinal-cord injury. (2007)
  • Author(s): Nishimura Y, Onoe T, Morichika Y, Perfiliev S, Tsukada H, Isa T
  • Journal Title: Science 318 Pages: 1150-1155
  • Peer Reviewed
• [Journal Article] Differentially expressed genes among motor and prefrontal areas of macaque neocortex. (2007)
  • Author(s): Sato A, Nishimura Y, Oishi T, Higo N, Murata Y, Onoe H, Saito K, Tsuboi F, Takahashi M, Isa T, Kojima T
  • Journal Title: Biochemical and Biophysical Research Communications 362 Pages: 665-669
  • Peer Reviewed
• [Journal Article] Activation of parieto-frontal stream during reaching and grasping studied by positron emission tomography in monkeys. (2007)
  • Author(s): Nishimura Y, Onoe T, Morichika Y, Tsukada H, Isa T
  • Journal Title: Neuroscience Research 59 Pages: 243-250
  • NAID: 10024417714
• [Journal Article] Quantitative analysis of saccade-like rapid eye movements in C57BL/6 mice. (2007)
  • Author(s): Sakatani T, Isa T
  • Journal Title: Neuroscience Research 58 Pages: 324-331
  • Peer Reviewed
• [Journal Article] Hall WC , Identity of a pathway for saccadic suppression. (2007)
  • Author(s): Lee PH, Sooksawate T, Yanagawa Y, Isa K, Isa T
  • Journal Title: Proceedings of National Academy of Sciences USA 104 Pages: 6824-6827
  • Peer Reviewed
• [Journal Article] Activation of parieto-frontal stream during reaching and grasping studied by positron emission tomography in monkeys (2007)
  • Author(s): Nishimura Y, Onoe T, Morichika Y, Tsukada H, Isa T
  • Journal Title: Neuroscience Research 59 Pages: 243-250
  • NAID: 10024417714
  • Peer Reviewed
• [Journal Article] Differentially expressed genes among motor and prefrontal areas of macaque neocortex (2007)
  • Author(s): Sato A, Nishimura Y, Oishi T, Higo N, Murata Y, Onoe H, Saito K, Tsuboi F, Takahashi M, Isa T, Kojima T
  • Journal Title: Biochemical and Biophysical Research Communications 362 Pages: 665-669
  • Peer Reviewed
• [Journal Article] Time-dependent central compensatory mechanism of finger dexterity after spinal-cord injury (2007)
  • Author(s): Nishimura Y, Onoe T, Morichika Y, Perfiliev S, Tsukada H, Isa T
  • Journal Title: Science 318 Pages: 1150-1155
  • Peer Reviewed
• [Journal Article] Identity of a pathway for saccadic suppression. (2007)
  • Author(s): Lee PH, Sooksawate T, Yanagawa Y, Isa K, Isa T, Hall WC
  • Journal Title: Proceedings of National Academy of Sciences USA Vol.104 Pages: 6824-6827
• [Journal Article] Quantitative analysis of saccade-like rapid eye movements in C57BL/6 mice. (2007)
  • Author(s): Sakatani T, Isa T
  • Journal Title: Neuroscience Research (in press)
• [Journal Article] Direct and indirect cortico-motoneuronal pathways and control of hand/arm movements. (2007)
  • Author(s): Isa T, Ohki Y, Alstermark B, Pettersson LG, Sasaki S
  • Journal Title: Physiology Vol.22 Pages: 145-152
• [Journal Article] Properties of cholinergic responses in neurons in the intermediate gray layer of rat superior colliculus. (2006)
  • Author(s): Sooksawate T, Isa T
  • Journal Title: European Journal of Neuroscience 24 Pages: 3096-3108
  • Peer Reviewed
• [Journal Article] Electrophysiological abnormalities precede apparent histological demyelination in the central nervous system of mice overexpressing proteolipid protein. (2006)
  • Author(s): Tanaka H, Ikenaka K, Isa T
  • Journal Title: Journal of Neuroscience Research 84 Pages: 1206-1216
  • Peer Reviewed
• [Journal Article] Properties of propriospinal neurons in the C3-C4 segments mediating disynaptic pyramidal excitation to forelimb motoneurons in the macaque monkey. (2006)
  • Author(s): Isa T, Ohki Y, Seki K, Alstermark B
  • Journal Title: Journal of Neurophysiology 95 Pages: 3674-3685
  • Peer Reviewed
• [Journal Article] Properties of cholinergic responses in neurons in the intermediate gray layer of rat superior colliculus. (2006)
  • Author(s): Sooksawate T, Isa T
  • Journal Title: European Journal of Neuroscience Vol.24 Pages: 3069-3108
• [Journal Article] Properties of propriospinal neurons in the C3-C4 segments mediating disynaptic pyramidal excitation to forelimb motoneurons in the macaque monkey. (2006)
  • Author(s): Isa T, Ohki Y, Seki K, Alstermark B
  • Journal Title: Journal of Neurophysiology Vol.95 Pages: 3674-3685
• [Journal Article] Electrophysiological abnormalities precede apparent histological demyelination in the central nervous of mice overexpressing proteolipid protein. (2006)
  • Author(s): Tanaka, Ikenaka K, Isa T
  • Journal Title: Journal of Neuroscience Research Vol.84 Pages: 1206-1216
• [Journal Article] Compensatory changes at the cerebral cortical level after spinal cord Injury(review)
  • Author(s): Nishimura Y, Isa T
  • Journal Title: The Neuroscientist (In press)
  • Peer Reviewed
• [Presentation] Spinal cord interneuronal network and functional electrical stimulation of the spinal cord with chronically implanted electrodes. (2009)
  • Author(s): 伊佐正
  • Organizer: 日英ブレイン・マシン・インターフェース国際ワークショップ
  • Place of Presentation: 有楽町朝日ホール
  • Year and Date: 2009-02-12
• [Presentation] Spinal cord interneuronal network and functional electrical stimulation of the spinal cord with chronically implanted electrodes (2009)
  • Author(s): 伊佐正
  • Organizer: 日英ブレイン・マシン・インターフェース国際ワークショップ
  • Place of Presentation: 有楽町朝日ホール
  • Year and Date: 2009-02-12
• [Presentation] 脳・脊髄損傷後の機能回復過程の可視化 (2009)
  • Author(s): 伊佐正
  • Organizer: 第3回分子イメージング研究センターシンポジウム
  • Place of Presentation: 放射線医学総合研究所
  • Year and Date: 2009-01-22
• [Presentation] 脊髄損傷後の機能回復戦略 (2008)
  • Author(s): 伊佐正
  • Organizer: 神経科学セミナー
  • Place of Presentation: 東京都神経科学総合研究所
  • Year and Date: 2008-10-07
• [Presentation] 脳・脊髄部分損傷後の機能回復に関するBMIの応用に関する考え方 (2008)
  • Author(s): 伊佐正
  • Organizer: 日本脳神経外科学会 第67回学術総会シンポジウム
  • Place of Presentation: 盛岡グランドホテル
  • Year and Date: 2008-10-01
• [Presentation] 機能回復と脳活動 (2008)
  • Author(s): 伊佐正
  • Organizer: 第2回痛みの理学療法学研究大会
  • Place of Presentation: 名古屋大学
  • Year and Date: 2008-09-27
• [Presentation] 損傷脳の生存戦略 (2008)
  • Author(s): 伊佐正
  • Organizer: 第16回「脳の世紀」シンポジウム
  • Place of Presentation: 有楽町朝日ホール
  • Year and Date: 2008-09-04
• [Presentation] 損傷脳の生存戦略 (2008)
  • Author(s): 伊佐正
  • Organizer: 国立精神・神経センター神経研究所 研究所セミナー
  • Year and Date: 2008-07-22
• [Presentation] 脊髄損傷後の手指の巧緻運動の機能代償機構 (2008)
  • Author(s): 伊佐正
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2008-07-11
• [Presentation] 脊髄損傷後の手指の巧緻運動の機能代償機構 (2008)
  • Author(s): 伊佐正
  • Organizer: 神経組織の成長・再生・移植研究会第23回学術集会
  • Place of Presentation: ホテルスプリングス幕張
  • Year and Date: 2008-05-17
• [Presentation] 脊髄損傷後の手指の巧緻運動の機能代償機構 (2008)
  • Author(s): 伊佐正
  • Organizer: 第37回日本脊椎脊髄病学会
  • Place of Presentation: 京王プラザホテル
  • Year and Date: 2008-04-24
• [Presentation] Functional reorganization of corticospinal projections in rats with neonatal hemidecortication (2008)
  • Author(s): 梅田 達也、高橋 雅人、伊佐 かおる、伊佐 正
  • Organizer: 第85回日本生理学会大会
  • Place of Presentation: 京王プラザホテル東京
  • Year and Date: 2008-03-27
• [Presentation] Changes in regional brain activities involved in manipulation task after primary motor cortex lesion:A pilot PET study with a macaque monkey (2008)
  • Author(s): 村田 弓、肥後 範行、西村 幸男、大石 高生、塚田 秀夫、伊佐 正
  • Organizer: 第85回日本生理学会大会
  • Place of Presentation: 京王プラザホテル東京
  • Year and Date: 2008-03-26
• [Presentation] 損傷から立ち直るための脳の仕組み (2008)
  • Author(s): 伊佐正
  • Organizer: 第5回自然科学研究機構シンポジウム
  • Place of Presentation: 国際フォーラム
  • Year and Date: 2008-03-20
• [Presentation] 損傷から立ち直るための脳の仕組み (2008)
  • Author(s): 伊佐 正
  • Organizer: 第5回自然科学研究機構シンポジウム
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2008-03-20
• [Presentation] Time-Dependent Central Compensatory Mechanisms of Finger Dexterity after Spinal Cord Injury (2008)
  • Author(s): Nishimura, Y, Onoe, H.(RIKEN), Morichika, Y., Perfiliev, S., Tukada, H., Isa, T.
  • Organizer: The 12th Conference of Peace through Mind/Brain Science
  • Place of Presentation: Hamamatsu
  • Year and Date: 2008-02-06
• [Presentation] ブレインマシンインタフェイス研究の現状と展望 (2008)
  • Author(s): 伊佐正
  • Organizer: 第47回日本定位・機能神経外科学会
  • Place of Presentation: アクトシティ浜松
  • Year and Date: 2008-01-25
• [Presentation] 脳の損傷から立ち直るために (2007)
  • Author(s): 伊佐正
  • Organizer: CREST第3回公開シンポジウム
  • Place of Presentation: 虎ノ門パストラル
  • Year and Date: 2007-11-10
• [Presentation] 「脳の損傷から立ち直るために」 (2007)
  • Author(s): 伊佐 正
  • Organizer: CREST第3回公開シンポジウム
  • Place of Presentation: 虎ノ門パストラル
  • Year and Date: 2007-11-10
• [Presentation] Saliency-based of spontaneous saccades in monkeys with unilateral lesion of primary visual cortex. (2007)
  • Author(s): Laurent Itti, Masatoshi Yoshida, David Berg, Takuro Ikeda, Rikako Kato, Kana Tkaura, Tadashi Isa
  • Organizer: 第37回 Annual meeting of the Society for Neuroscience
  • Place of Presentation: 米国
  • Year and Date: 2007-11-06
• [Presentation] Choice-related modulation of neural activity in the superior colliculus of monkeys with blindsight (2007)
  • Author(s): Masatoshi Yoshida、Kana Takaura、Tadashi Isa
  • Organizer: 第37回Annual meeting of the Society for Neuroscience
  • Place of Presentation: San Diego Convention Center、米国
  • Year and Date: 2007-11-06
• [Presentation] Saliency-based guidance of spontaneous saccades in monkeys with unilateral lesion of primary visual cortex (2007)
  • Author(s): Laurent Itti, Masatoshi Yoshida, David Berg, Takuro Ikeda, Rikako Kato, Kana Takaura, Tadashi Isa
  • Organizer: 第37回Annual meeting of the Society for Neuroscience
  • Place of Presentation: San Diego Convention Center、米国
  • Year and Date: 2007-11-06
• [Presentation] Increase of intermuscular coherence independent of cortical activity during recovery from corticospinal tract lesion in monkeys (2007)
  • Author(s): Yukio Nishimura, Tadashi Isa
  • Organizer: 第37回Annual meeting of the Society for Neuroscience
  • Place of Presentation: San Diego Convention Center、米国
  • Year and Date: 2007-11-04
• [Presentation] Enhanced ex cession of GAP-43 mRNA in the sensorimotor cortex of the macaque monkey after the lesion of the lateral corticosuinal tract (2007)
  • Author(s): Noriyuki Higo、Yukio Nishimura、Yumi Murata, Takao Ooishi、Kimika Saitoh、Humiharu Tsuboi、Tadashi Isa
  • Organizer: 第37回Annual meeting of the Society for Neuroscience
  • Place of Presentation: San Diego Convention Center、米国
  • Year and Date: 2007-11-04
• [Presentation] Gene ex ression analvsis of motor-related areas and prefrontal area of the monkey neocortex (2007)
  • Author(s): Akira Satoh、Yukio Nishimura、Takao Ooishi、Noriyuki Higo、Yumi Murata、Hirotaka Onoe、Tadashi Isa
  • Organizer: 第37回Annual meeting of the Society for Neuroscience
  • Place of Presentation: San Diego Convention Center、米国
  • Year and Date: 2007-11-04
• [Presentation] Function of striatal visual pathway in visual attention:inhibition of return and attention capture (2007)
  • Author(s): Takuro Ikeda, Tadashi Isa
  • Organizer: 第37回Annual meeting of the Society for Neuroscience
  • Place of Presentation: San Diego Convention Center、米国
  • Year and Date: 2007-11-03
• [Presentation] サル大脳新皮質の運動関連領野と前頭前野における網羅的遺伝子発現解析 (2007)
  • Author(s): 佐藤 明、西村 幸男、大石 高生、肥後 範行、村田 弓、尾上 浩隆、伊佐 正
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-09-11
• [Presentation] サルの頸髄レベルでの皮質脊髄路切断後における手指巧緻性の回復;C2での切断とC5での切断の回復比較 (2007)
  • Author(s): 坪井 史治、西村 幸男、斎藤 紀美香、高橋 雅人、伊佐 正
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-09-11
• [Presentation] 黒質網様部から上丘中間層GABA作動性ニューロンへの抑制性入力 (2007)
  • Author(s): 伊佐かおる、金田勝幸、柳川右千夫、小幡邦彦、伊佐正
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-09-10
• [Presentation] 一次視覚野除去後の損傷視野内における視覚運動変換過程への上丘の寄与 (2007)
  • Author(s): 高浦加奈、吉田正俊、伊佐正
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-09-10
• [Presentation] ニホンザル盲視モデルにおける残存視覚に対応した神経活動 (2007)
  • Author(s): 吉田 正俊、高浦 加奈、伊佐 正
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-09-10
• [Presentation] 精密把持遂行時の皮質-手指筋間コヒーレンスの空間的分布 (2007)
  • Author(s): 西村 幸男、伊佐 正
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-09-10
• [Presentation] 注意の誘引と復帰抑制における一次視覚野の機能の解明 (2007)
  • Author(s): 池田 琢朗、伊佐 正
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-09-10
• [Presentation] 外側皮質脊髄路損傷後の回復過程における神経成長関連タンパクGAP-43の脳内発現 (2007)
  • Author(s): 肥後 範行、西村 幸男、村田 弓、大石 高生、斎藤 紀美香、坪井 史治、伊佐 正
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-09-10
• [Presentation] 皮質脊髄路損傷後に大脳皮質活動とは独立したEMG-EMGコヒーレンスは増大する (2007)
  • Author(s): 西村 幸男、伊佐 正
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-09-10
• [Presentation] Plasticity for functional restoration of forelimb movements following neonatal unilateral decortication (2007)
  • Author(s): Anusara Vattanajun、高橋 雅人、伊佐 かおる、伊佐 正
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-09-10
• [Presentation] Large-scale change in the corticofugal projections in rats with neonatal hemi-decortication (2007)
  • Author(s): 高橋 雅人、Anusara Vattanajun、梅田 達也、伊佐 かおる、伊佐 正
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-09-10
• [Presentation] 注視解除による視覚探索への影響 (2007)
  • Author(s): 加藤 利佳子、伊佐 正
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-09-10
• [Presentation] サル皮質脊髄路:一次運動野における手指制御領域から脊髄への軸索投射の定量的解析 (2007)
  • Author(s): 齋藤 紀美香、西村 幸男、大石 高生、肥後 範行、村田 弓、伊佐 正
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-09-10
• [Presentation] Neural correlate of residual vision in monkey with blindsight. (2007)
  • Author(s): Masatoshi Yoshida, Kana Takaura, Tadashi Isa
  • Organizer: 第11回 Association for the Scientific Study of Consciousness
  • Place of Presentation: 米国
  • Year and Date: 2007-06-23
• [Presentation] Neural correlate of residual vision in monkey with blindsight (2007)
  • Author(s): Masatoshi Yoshida, Kana Takaura, Tadashi Isa
  • Organizer: 第11回Association for the Scientific Study of Consciousness
  • Place of Presentation: ラスベガス、Imperial Palace Hotel
  • Year and Date: 2007-06-23
• [Presentation] 一次視覚野損傷後の視覚運動変換機構-盲視モデルとしての考察- (2007)
  • Author(s): 伊佐正
  • Organizer: 玉川大学脳科学研究所設立記念シンポジウム
  • Place of Presentation: 玉川学園チャペル
  • Year and Date: 2007-05-19
• [Presentation] 「一次視覚野損傷後の視覚運動変換機構--盲視モデルとしての考察-」 (2007)
  • Author(s): 伊佐 正
  • Organizer: 玉川大学脳科学研究所設立記念シンポジウム
  • Place of Presentation: 玉川学園チャペル
  • Year and Date: 2007-05-19
• [Presentation] Role of striatal visual pathway in Inhibition of Return (2007)
  • Author(s): Takuro Ikeda, Tadashi Isa
  • Organizer: 第7回Vision Science Society年会
  • Place of Presentation: 米国
  • Year and Date: 2007-05-13
• [Presentation] Is residual vision in monkeys with unilateral lesion in the primary visual cortex like normal, near-threshold vision ? (2007)
  • Author(s): Masatoshi Yoshida, Kana Takaura, Tadashi Isa
  • Organizer: 第7回Vision Science Society年会
  • Place of Presentation: 米国
  • Year and Date: 2007-05-13
• [Presentation] Is residual vision in monkeys with unilateral lesion in the primaryvisual cortex like normal,near-threshold vision? (2007)
  • Author(s): Masatoshi Yoshida, Kana Takaura, Tadashi Isa
  • Organizer: 第7回Vision Science Society年会
  • Place of Presentation: サラソタハイアットホテル、フロリダ、米国
  • Year and Date: 2007-05-13
• [Presentation] Role of striatal visual pathway in Inhibition of Return (2007)
  • Author(s): Takuro Ikeda, Tadashi Isa
  • Organizer: 第7回Vision Science Society年会
  • Place of Presentation: サラソタハイアットホテル、フロリダ、米国
  • Year and Date: 2007-05-13
• [Presentation] Investigation of spontaneous saccades based on the saliency model in monkeys with unilateral lesion of primary visual cortex. (2007)
  • Author(s): Laurent Itti, Masatoshi Yoshida, David Berg, Takuro Ikeda, Rikako Kato, Kana Tkaura, Tadashi Isa
  • Organizer: 第7回Vision Science Society年会
  • Place of Presentation: 米国
  • Year and Date: 2007-05-11
• [Presentation] Top-down attention on the visuomotor processing without the primary visual cortex(V1): an experimental study in monkeys with unilateral lesion of V1 (2007)
  • Author(s): Tadashi Isa
  • Organizer: 第7回Vision Science Society年会
  • Place of Presentation: 米国
  • Year and Date: 2007-05-11
• [Presentation] Top-down attention onthe visuomotor processing without the primary visual cortex(V1):an experimental study in monkeys with unilaterallesion of V1 (2007)
  • Author(s): Tadashi Isa
  • Organizer: 第7回Vision Science Society年会
  • Place of Presentation: サラソタハイアットホテル、フロリダ、米国
  • Year and Date: 2007-05-11
• [Presentation] Investigation of spontaneous saccades based on the saliency model in monkeys with unilateral lesion of primary visual cortex (2007)
  • Author(s): Laurent Itti, Masatoshi Yoshida, David Berg, Takuro Ikeda, Rikako Kato, Kana Takaura, Tadashi Isa
  • Organizer: 第7回Vision Science Society年会
  • Place of Presentation: サラソタハイアットホテル、フロリダ、米国
  • Year and Date: 2007-05-11
• [Book] Eyes, Retina and Visual System of the Mouse (eds Calupa Leo. M. & William R) (分担執筆) (2008)
  • Author(s): Sakatani T, Isa T
  • Total Pages: 12
  • Publisher: MIT Press
• [Book] 運動制御回路の構造・機能と損傷後機能代償。ブレインサイエンス・レビュー(分担執筆) (2007)
  • Author(s): 伊佐 正
  • Total Pages: 18
  • Publisher: ブレインサイエンス振興財団
• [Book] 脳・脊髄損傷後の機能回復に関する研究の動向。ブレイン・マシン・インタフェース (2007)
  • Author(s): 伊佐 正
  • Total Pages: 25
  • Publisher: (編)「脳を活かす」研究会
• [Book] Group report : Microcircuits in the motor system. "Microcircuits. The interface between neurons and global brain function." (eds. S. Grillner & A.M. Graybiel), pp77-104 (2006)
  • Author(s): Kiehn, O., Buschges, A., Duch, C., Grillner, S., Isa, T., Lansner, A., Pfluger, H.-J., Richter, D.W., Sillar, K.T., smith, J.C., Sparks, D.L.
  • Publisher: The MIT Press
• [Book] Background paper for 93rd Dahlem Workshop on Microcircuits; The interface between Neurons and Global Brain Function, pp1-34 (2006)
  • Author(s): Isa T & Sparks D
  • Publisher: Microcircuit of the Superior Colliculus : A Neuronal Machine that Determines Timing and Endpoint of Saccadic Eye Movements
• [Book] Microcircuits. The interface between neurons and global brain function. "(eds. S. Grillner, A.M. Graybiel) (2006)
  • Author(s): Isa T, Sparks D
  • Publisher: MIT Press
• [Remarks]
  • URL: http://www.nips.ac.jp/news/2007/20080221/
• [Remarks]
  • URL: http://www.nips.ac.jp/news/2007/20080131/
• [Remarks]
  • URL: http://www.nips.ac.jp/news/2007/20071214/