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Trial of human tissue-substituted mice and its application to human diseases.

Research Project

Project/Area Number 18200028
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory animal science
Research InstitutionTokyo Metropolitan Organization for Medical Research

Principal Investigator

YONEKAWA Hiromichi  Tokyo Metropolitan Organization for Medical Research, 東京都臨床医学総合研究所, 参事研究員 (30142110)

Co-Investigator(Kenkyū-buntansha) KOHARA Michinori  財団法人東京都医学研究機構, 東京都臨床医学総合研究所, 参事研究員 (10250218)
多屋 長治  東京都臨床医学総合研究所, 主任研究員 (90175456)
習田 昌裕  東京都臨床医学総合研究所, 研究員 (10356256)
設楽 浩志 (設楽 裕志)  東京都臨床医学総合研究所, 研究員 (90321885)
石井 里絵  東京都臨床医学総合研究所, 研究員 (00425688)
Co-Investigator(Renkei-kenkyūsha) TAYA Choji  財団法人東京都医学研究機構, 東京都臨床医学総合研究所, 主任研究員 (90175456)
SHITARA Hiroshi  財団法人東京都医学研究機構, 東京都臨床医学総合研究所, 研究員 (90321885)
ISHII Rie  財団法人東京都医学研究機構, 東京都臨床医学総合研究所, 研究員 (00425688)
SHUDA Masahiro  財団法人東京都医学研究機構, 東京都臨床医学総合研究所, 研究員 (10356256)
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥47,060,000 (Direct Cost: ¥36,200,000、Indirect Cost: ¥10,860,000)
Fiscal Year 2008: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
Fiscal Year 2007: ¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000)
Fiscal Year 2006: ¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Keywords標的細胞ノックアウト法 / TRECK法 / SCIDマウス / ヒト細胞置換マウス / 肝実質細胞 / SCID-Huマウス / ヒト肝実質細胞 / HCV / 移植 / HSV-TK / ガンシクロビル / ヒト臍帯血 / 肝臓特異的プロモータ
Research Abstract

体内にヒトの肝臓を持つことのできる遺伝子改変マウスの作製を行った。ヒト細胞を移植できるSCIDマウスに標的細胞ノックアウト法を施し、マウス肝細胞を部分的に除去した後、ヒトの培養肝細胞を移植した。その結果、ヒトの肝臓がマウスの肝臓内で生着し、血液中にヒトのアルブミンが放出されたことを確認した。しかし、高い頻度でのヒト肝細胞への置換には至らす、現在その条件をさらに検討している。

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (65 results)

All 2009 2008 2007 2006 Other

All Journal Article (33 results) (of which Peer Reviewed: 28 results) Presentation (27 results) Book (4 results) Remarks (1 results)

  • [Journal Article] Disruption of IFN Signaling and HCV Synergistically Enhance Lympho- proliferation through Type II CD95 and Interleukins.2009

    • Author(s)
      K. Machida, K. Tsukiyama-Kohara, E. Seike, S. Tone, Y. Hayashi, Y. Kasama, M. Shimizu, H. Takahashi, C. Taya, H. Yonekawa, N. Tanaka, M. Kohara.
    • Journal Title

      Gastroenterology in press

      Pages: 0-0

    • Related Report
      2008 Final Research Report
  • [Journal Article] RNA polymerase to make a highly active JFH1-type polymerase by mutation of the thumb domain.2009

    • Author(s)
      L. Weng, J. Du, J. Zhou, J. Ding, T. Wakita, M. Kohara, T. Toyoda.
    • Journal Title

      Arch Virol. 154

      Pages: 765-773

    • Related Report
      2008 Final Research Report
  • [Journal Article] Synthesis of nuclease-resistant siRNAs possessing universal overhangs.2009

    • Author(s)
      Y. Ueno, Y. Watanabe, A. Shibata, K. Yoshikawa, T. Takano, M. Kohara, Y Kitade
    • Journal Title

      Bioorganic & Medicinal Chemistry. 17

      Pages: 1974-81

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Disruption of IFN Signaling and HCV Synergistically Enhance Lympho proliferation through Type II CD95 and Interleukins2009

    • Author(s)
      K. Machida, H. Yonekawa, M. Kohara, et al.
    • Journal Title

      Gastroenterology (印刷中)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modification of hepatitis C virus 1b RNA polymerase to make a highly active JFH1-type polymerase by mutation of the thumb domain2009

    • Author(s)
      L. Weng, M. Kohara, et al.
    • Journal Title

      Arch Virol. (印刷中)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of nuclease-resistant siRNAs possessing universal overhangs2009

    • Author(s)
      Y. Ueno, Y. Watanabe, A. Shibata, K. Yoshikawa, T. Takano, M. Kohara, Y. Kitade
    • Journal Title

      Bioorganic & Medicinal Chemistry (印刷中)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A mutational shift from domain III to II in the internal ribosome entry site of hepatitis C virus after interferon-ribavirin therapy.2008

    • Author(s)
      K. Ogata, T. Kashiwagi, J. Iwahashi, K. Hara, H. Honda, T. Ide, R. Kumashiro, M. Kohara, M Sata, N. Hamada.
    • Journal Title

      Arch Virol. 153(8)

      Pages: 1575-9

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prior immunization with SARS- CoV nucleocapsid protein causes severe pneumonia in mice infected with SARS- CoV.2008

    • Author(s)
      F. Yasui, C. Kai, M. Kitabatake, S. Inoue, M. Yoneda, S. Yokochi, R. Kase, S. Sekiguchi, K Morita, T Hishima, H Suzuki, K. Karamatsu, Y. Yasutomi, H. Shida, M. Kidokoro, K. Mizuno, K. Matsushima, M. Kohara.
    • Journal Title

      J. Immunology 181

      Pages: 6337-48

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of hepatitis C virus infection and expression in vitro and in vivo by recombinant adenovirus express- ing short hairpin RNA.2008

    • Author(s)
      N. Sakamoto, Y. Tanabe, T. Yokota, K. Satoh, Y. Sekine-Osajima, M. Nakagawa, Y. Itsui, M. Tasaka, Y. Sakurai, C.-H. Chen, M. Yano, S. Ohkoshi, Y. Aoyagi, S. Maekawa, N. Enomoto, M. Kohara, M. Watanabe.
    • Journal Title

      J. Gastroentero- logy Hepatology. 23

      Pages: 1437-47

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparative aspects on the role of polypyrimidine tract-binding protein in internal initiation of hepatitis C virus and picornavirus RNAs2008

    • Author(s)
      T. Nishimura, M. Saito, T. Takano, A. Nomoto, M. Kohara, K. Tsukiyama Kohara.
    • Journal Title

      Compara. Immu. Microbio. Infect. Dises. 31

      Pages: 435-448

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hepatitis C virus NS5A protein interacts with and negatively regulates the non-receptor protein-tyrosine kinase Syk.2008

    • Author(s)
      S. Inubushi, M. Nagano-Fujii, K. Kitayama, M. Tanaka, A. Chunying, H. Yokozaki, H. Yamamura, H. Nuriya, M. Kohara, K. Sada, H. Hotta.
    • Journal Title

      J. Gen. Virology 89

      Pages: 1231-1242

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prior immunization with SARS-CoV nucleocapsid protein causes severe pneumonia in mice infected with SARS-CoV2008

    • Author(s)
      F. Yasui, M. Kohara, et al.
    • Journal Title

      J. Immunology 181

      Pages: 6337-6348

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hepatitis C virus NS5A protein interacts with and negatively regulates the non-receptor protein-tyrosine kinase Syk2008

    • Author(s)
      S. Inubushi, M. Nagano-Fujii, K. Kitayama, M. Tanaka, C. An, H. Yokozaki, H. Yamamura, H. Nuriya, M. Kohara, K. Sadaand, H. Hotta
    • Journal Title

      J. Gen. Virology 89

      Pages: 1231-1242

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparative aspects on the role of polypyrimidine tract-binding protein in internal initiation of hepatitis C virus and picornavirus RNAs2008

    • Author(s)
      T. Nishimura, M. Saito, T. Takano, A. Nomoto, M. Kohara, K. Tsukiyama-Kohara
    • Journal Title

      Compara. Immu. Microbio. Infect. Dises. 31

      Pages: 435-448

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of hepatitis C virus infection and expression in vitro and in vivo by recombinant adenovirus expressing short hairpin RNA2008

    • Author(s)
      N. Sakamoto, Y. Tanabe, T. Yokota, K. Satoh, Y. Sekine-Osajima, M. Nakagawa, Y. Itsui, M. Tasaka, Y. Sakurai, C. Cheng-Hsin, M. Yano, S. Ohkoshi, Y. Aoyagi, S. Maekawa, N. Enomoto, M. Kohara, M. Watanabe
    • Journal Title

      J. Gastroenterology Hepatology 23(9)

      Pages: 1437-47

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A mutational shift from domain III to II in the internal ribosome entry site of hepatitis C virus after interferon-ribavirin therapy2008

    • Author(s)
      K. Ogata, T. Kashiwagi, J. Iwahashi, K. Hara, H. Honda, T. Ide, R. Kumashiro, M. Kohara, M. Sata, N. Hamada
    • Journal Title

      Arch Virol. 153(8)

      Pages: 1575-9

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of hepatitis C virus infection and expression in vitro and in vivo by recombinant adenovirus expressing short hairpin RNA.2008

    • Author(s)
      Sakamoto N., et. al.
    • Journal Title

      J.Gastroenterology Hepatology (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparative aspects on the role of polypyrimidine tract-binding protein in internal initiation of hepatitis C virus and picornavirus RNAs.2008

    • Author(s)
      Nishimura T., et. al.
    • Journal Title

      Compara.Immu.Microbio.Infect.Dises. (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic application of RNA interference for Hepatitis C Virus.2007

    • Author(s)
      T. Watanabe, T. Umehara, M. Kohara.
    • Journal Title

      Advanced Drug Delivery Reviews 59

      Pages: 1263-1276

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Liver target delivery of small interfering RNA to the HCV gene by lactosylated cationic liposome.2007

    • Author(s)
      T. Watanabe, T. Umehara, F. Yasui, S. Nakagawa, J. Yano, T. Ohgi, S. Sonoke, K. Inoue, M. Yoshiba, M. Kohara.
    • Journal Title

      J. Hepatology 47

      Pages: 744-750

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Survival of liver failure pigs by transplantation of reversibly immortalized human hepatocytes with Tamoxifen-mediated self-recombination.2007

    • Author(s)
      T. Totsugawa, C. Yong, J.D. Rivas-Carrillo, A. Soto-Gutierrez, N. Navarro-Alvarez, H. Noguchi, T. Okitsu, K.A. Westerman, M. Kohara, M. Reth, N. Tanaka, P. Leboulch, N. Kobayashi.
    • Journal Title

      J. Hepatology 47

      Pages: 74-82

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of CTL epitopes in hepatitis C virus by a genome-w ide computational scanning and a rational design of peptide vaccine.2007

    • Author(s)
      T. Mashiba, K. Udaka, Y. Hirachi, Y. Hiasa, T. Miyakawa, Y. Satta, T. Osoda, S. Kataoka, M. Kohara, M. Onji.
    • Journal Title

      Immunogenetics 59

      Pages: 197-209

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of a Cyclophilin Inhibitor in Hepatitis C Virus-Infected Chimeric Mice In Vivo.2007

    • Author(s)
      K. Inoue, T. Umehara, U. T. Ruegg, F. Yasui, T. Watanabe, H. Yasuda, M. Yoshiba, J.-M. Dumont, P. Scalfaro, M. Kohara.
    • Journal Title

      Hepatology 45

      Pages: 921-928

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of Hsp90 suppresses HCV replication in replicon cell lines and in chimeric mice with humanized liver.2007

    • Author(s)
      S. Nakagawa, T. Umehara, C. Matsuda, S. Kuge, M. Sudoh M. Kohara.
    • Journal Title

      Biochem. Biophys. Res. Commun. 353

      Pages: 882-888

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] SARS- CoV spike protein recombinant vaccinia virus efficiently induces neutralizing antibodies in spite of pre-immunization with vaccinia virus.2007

    • Author(s)
      M. Kitabatake, S. Inoue, F. Yasui, S. Yokochi, M. Arai, K. Morita, H. Shida, M. Kidokoro, F. Murai, M. L.Quynh, K. Matsushima, M. Kohara.
    • Journal Title

      Vaccine 25

      Pages: 630-637

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of Hsp90 suppresses HCV replication in replicon cell lines and in chimeric mice with humanized liver.2007

    • Author(s)
      Nakagawa S., et. al.
    • Journal Title

      Biochem.Biophys.Res.Commun. 353

      Pages: 882-888

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of the cyclophilin inhibitor DEBIO-025 in hepatitis C virus-infected chimeric mice in vivo.2007

    • Author(s)
      Inoue K., et. al.
    • Journal Title

      Hepatology 45

      Pages: 921-928

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Liver target delively of small interfering RNA to the HCV gene by lactosylated cationic liposome.2007

    • Author(s)
      Watanabe T., et. al.
    • Journal Title

      J. Hepatology 47

      Pages: 744-750

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of CTL epitopes in hepatitis C virus by a genome-wide computational scanning and a rational design of peptide vaccine.2007

    • Author(s)
      Mashiba T., et. al.
    • Journal Title

      Immunogenetics 59

      Pages: 197-209

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Survival of liver failure pigs by transplantation of reversibly immortalized human hepatocytes with Tamoxifen-mediated self-recombination.2007

    • Author(s)
      Totsugawa T., et. al.
    • Journal Title

      J.Hepatology 47

      Pages: 74-82

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of Hsp90 suppresses HCV replication in replicon cell lines and in chimeric mice with humanized liver.2007

    • Author(s)
      S.Nakagawa, T.Umehara, C.Matsuda, S.Kuge, M.i Sudoh, M.Kohara.
    • Journal Title

      Biochem. Biophys. Res. Commun. 353

      Pages: 882-888

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Serine palmitoyltransferase inhibitor suppresses HCV replication in a mouse model.2006

    • Author(s)
      T.Umehara, M.Sudoh, F.Yasui, C.Matsuda, Y.Hayashi, M.i Kohara
    • Journal Title

      Biochem. Biophys. Res. Commun. 346

      Pages: 67-73

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Maintenance of mouse, rat, and pig pancreatic islet functions by coculture with human islet-derived fibroblasts.2006

    • Author(s)
      Miki A, Narushima M, Okitsu T, Takeno Y, Sato-Gutierrez A, Rivas-Carrillo JD, Navarro-Alvarez N, Chen Y, Tanaka K, Noguchi H, Matsumoto S, Kohara M, Lakey JR, Kobayashi E, Tanaka N, Kobayashi N.
    • Journal Title

      Cell Transplant. 15

      Pages: 325-334

    • Related Report
      2006 Annual Research Report
  • [Presentation] ヒト肝置換Tgマウスの作製方法2008

    • Author(s)
      米川博通、松岡邦枝
    • Organizer
      第7回研究交流フォーラム
    • Place of Presentation
      東京
    • Year and Date
      2008-02-27
    • Related Report
      2008 Final Research Report
  • [Presentation] 標的細胞ノックアウト法の胎仔組織への応用2008

    • Author(s)
      松岡邦枝、土屋真衣子、設楽浩志、松尾千古、河野憲二、米川博通
    • Organizer
      日本実験動物科学技術2008(第55回日本実験動物学会総会・第42回日本実験動物技術者協会総会
    • Place of Presentation
      仙台
    • Related Report
      2008 Final Research Report
  • [Presentation] Improvement of a tissue-specific gene expression for TRECK method using a BAC clone.2008

    • Author(s)
      Yonekawa, H., Shibata, K., Sekine, M., Matsuoka, K., Shitara, H., Taya, C. Amano, T.
    • Organizer
      The 22nd International Mammalian Genome Conference (IMGC2008)
    • Place of Presentation
      Prague, Czech
    • Related Report
      2008 Final Research Report
  • [Presentation] 標的細胞ノックアウト法の胎仔組織への応用2008

    • Author(s)
      松岡邦枝、土屋真衣子、設楽浩志、松尾千古、河野憲二、米川博通
    • Organizer
      BMB2008(第31回日本分子生物学会年会、第81回日本生化学会大会合同大会)
    • Place of Presentation
      神戸
    • Related Report
      2008 Final Research Report
  • [Presentation] 新規HCV持続感染モデルマウスの作製とその病態解析2008

    • Author(s)
      関口 敏、飛田良美、千代智子、小原道法
    • Organizer
      第56回日本ウイルス学会学術集会
    • Place of Presentation
      岡山
    • Related Report
      2008 Final Research Report
  • [Presentation] 標的細胞ノックアウト法の胎仔組織への応用2008

    • Author(s)
      松岡邦枝, 米川博通, 他
    • Organizer
      (BMB2008)第31回日本分子生物学会年会、第81回日本生化学大会合同大会
    • Place of Presentation
      神戸
    • Related Report
      2008 Annual Research Report
  • [Presentation] Improvement of a tissue-specific gene expression for TRECK method using a BAC clone2008

    • Author(s)
      H. Yonekawa, K. Shibata, M. Sekine, K. Matsuoka, H. Shitara, C. Taya, T. Amano
    • Organizer
      The 22nd International Mammalian Genome Conference (IMGC2008)
    • Place of Presentation
      Prague, Czech
    • Related Report
      2008 Annual Research Report
  • [Presentation] 標的細胞ノックアウト法の胎仔組織への応用2008

    • Author(s)
      松岡邦枝, 米川博通, 他
    • Organizer
      日本実験動物科学技術2008(第55回日本実験動物学会総会・第42回日本実験動物技術者協会総会)
    • Place of Presentation
      仙台
    • Related Report
      2008 Annual Research Report
  • [Presentation] 宿主因子を標的にしたC型肝炎ウイルス複製の制御.2007

    • Author(s)
      小原 道法
    • Organizer
      第21回臨床肝臓カンファレンス
    • Place of Presentation
      東京
    • Year and Date
      2007-06-30
    • Related Report
      2007 Annual Research Report
  • [Presentation] スフィンゴ脂質とC型肝炎ウイルス複製.2007

    • Author(s)
      小原 道法
    • Organizer
      第49回日本脂質生化学会
    • Place of Presentation
      札幌
    • Related Report
      2007 Annual Research Report
  • [Presentation] Persistent infection of Hepatitis C Virus.2007

    • Author(s)
      Kohara M., et. al.
    • Organizer
      第7回あわじしま感染症・免疫フォーラム
    • Place of Presentation
      兵庫
    • Related Report
      2007 Annual Research Report
  • [Presentation] Inter-genotype comparison of replicating and infecting abilities using partitioned-full genomic replicon system.2007

    • Author(s)
      Arai M., et. al.
    • Organizer
      14^<th>International Symposium on Hepatitis C Virus & Related Viruses
    • Place of Presentation
      GLASGOW
    • Related Report
      2007 Annual Research Report
  • [Presentation] Hsp90 inhibitors suppress HCV replication in replicon cells andhumanized-liver mice.2007

    • Author(s)
      Nakagawa S. et. al.
    • Organizer
      14^<th>International Symposium on Hepatitis C Virus & Related Viruses
    • Place of Presentation
      GLASGOW
    • Related Report
      2007 Annual Research Report
  • [Presentation] Hepatitis C virus abrogates p53 activity through 24-dehydrocholesterol reductase.2007

    • Author(s)
      Nishimura T. et. al.
    • Organizer
      14^<th>International Symposium on Hepatitis C Virus & Related Viruses
    • Place of Presentation
      GLASGOW
    • Related Report
      2007 Annual Research Report
  • [Presentation] The cyclophillin inhibitor DEBIO-025 shows anti-HCV effect in chimeric mouse with human hepatocytes.2007

    • Author(s)
      Inoue K. et. al.
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] The novel regulatory pathway of TOM70 concerning with cell death.2007

    • Author(s)
      Takano T. et. al.
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] 免疫抑制作用のないサイクロスポリンA誘導体によるヒト肝臓キメラマウスにおけるHCV複製阻害.2007

    • Author(s)
      井上 和明, 他
    • Organizer
      第55回日本ウイルス学会学術集会
    • Place of Presentation
      札幌
    • Related Report
      2007 Annual Research Report
  • [Presentation] HCV関連抗原P70の同定及び解析.2007

    • Author(s)
      高野 貴士, 他
    • Organizer
      第55回日本ウイルス学会学術集会
    • Place of Presentation
      札幌
    • Related Report
      2007 Annual Research Report
  • [Presentation] C型肝炎ウイルス(HCV)のライフサイクルにおける宿主因子DHCR24の機能解析.2007

    • Author(s)
      斎藤 誠, 他
    • Organizer
      第55回日本ウイルス学会学術集会
    • Place of Presentation
      札幌
    • Related Report
      2007 Annual Research Report
  • [Presentation] C型肝炎ウイルス誘導蛋白質DHCR24によるp53の修飾制御.2007

    • Author(s)
      西村 知裕, 他
    • Organizer
      第55回日本ウイルス学会学術集会
    • Place of Presentation
      札幌
    • Related Report
      2007 Annual Research Report
  • [Presentation] Dehydrocholesterol reductase 24(DHCR24)をターゲットとした単クローン抗体処理のC型肝炎ウイルス複製細胞に対する生理学的影響を担う宿主因子の同定.2007

    • Author(s)
      佐藤 正明, 他
    • Organizer
      第55回日本ウイルス学会学術集会
    • Place of Presentation
      札幌
    • Related Report
      2007 Annual Research Report
  • [Presentation] A mouse model of peptide immunotherapy for hepatitis C virus.2007

    • Author(s)
      Kataoka S., et. al.
    • Organizer
      第37回日本免疫学会
    • Place of Presentation
      東京
    • Related Report
      2007 Annual Research Report
  • [Presentation] Characterization of HCV Replication regulatory by DHCR24.2007

    • Author(s)
      Takano T., et. al.
    • Organizer
      第30回日本分子生物学会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] Cyclophilins are essential for HCV RNA replication.2007

    • Author(s)
      Matsuda C. et. al.
    • Organizer
      第30回日本分子生物学会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] The role of DHCR24 in hepatocarcinogenesis and the viral life cycle during hepatitis C virus(HCV)infection.2007

    • Author(s)
      Saito M. et. al.
    • Organizer
      第30回日本分子生物学会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] Modification of p53 in full length HCV gene expressing cells.2007

    • Author(s)
      Nishimura T., et. al.
    • Organizer
      第30回日本分子生物学会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] Suppression of serine palmitoyltransferase inhibits HCV replication in mice with chimeric human liver.2006

    • Author(s)
      Umehara T., Sudoh M., Yasui F., Nakagawa S. and Kohara M.
    • Organizer
      20^<th> IUBMB International Congress of Biochemistry and Molecular Biology
    • Place of Presentation
      Kyoto
    • Related Report
      2008 Final Research Report
  • [Book] ファルマシア2008

    • Author(s)
      小原道法
    • Total Pages
      5
    • Publisher
      C型肝炎ウイルス:宿主因子を標的にしたHCV増殖抑制・阻害を目指して
    • Related Report
      2008 Annual Research Report
  • [Book] ウイルス2008

    • Author(s)
      平田雄一, 須藤正幸, 小原道法
    • Total Pages
      8
    • Publisher
      宿主因子を標的としたC型肝炎ウイルスの抑制
    • Related Report
      2008 Annual Research Report
  • [Book] Advanced Drug Delivery Reviews(分担執筆)2007

    • Author(s)
      Watanabe T., Umehara T., and Kohara M.
    • Publisher
      Elsevier
    • Related Report
      2007 Annual Research Report
  • [Book] 「スフィンゴ脂質生成とC型肝炎ウイルス増殖」2007

    • Author(s)
      楳原 琢哉、坂本 洋、須藤 正幸、小原 道法
    • Publisher
      BIO Clinica
    • Related Report
      2007 Annual Research Report
  • [Remarks]

    • URL

      http://www.rinshoken.or.jp/LAS/index-jp.htm

    • Related Report
      2007 Annual Research Report

URL: 

Published: 2006-04-01   Modified: 2016-04-21  

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