A basic study of application of high-intensity focused ultrasound for fetal therapy

• Project/Area Number: 18200035
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Medical systems
• Research Institution: Showa University
• Principal Investigator: OKAI Takashi Showa University, 医学部, 教授 (40126016)
• Co-Investigator(Kenkyū-buntansha): 市塚 清健 昭和大学, 医学部, 講師 (00338451) ; 関沢 明彦 昭和大学, 医学部, 准教授 (10245839) ; 松岡 隆 昭和大学, 医学部, 助教 (20349111) ; 梅村 晋一郎 東北大学, 大学院・医工学研究科, 教授 (20402787) ; 九島 巳樹 昭和大学, 医学部, 准教授 (80161628)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥36,270,000 (Direct Cost: ¥27,900,000、Indirect Cost: ¥8,370,000); Fiscal Year 2008: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000); Fiscal Year 2007: ¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000); Fiscal Year 2006: ¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000)
• Keywords: 低侵襲治療システム / 強出力集束超音波(HIFU) / 胎児治療 / HIFU / 動物実験モデル / 胎児閉塞性尿路障害 / TTTS / 動物実験

Research Abstract

本研究は強出力集束超音波(HIFU)を用いて血流依存性疾患(胎児腫瘍など)、胎児閉塞性尿路障害、胎児腔水症、双胎間輸血症候群に対する胎児治療に向けた基礎実験を行うことで臨床応用が可能かどうかを知ることを目的に行われた。実験結果から胎児胎内の血流遮断が可能なこと、血流遮断により腫瘍の増殖抑制ができることを確認した。また胎児膀胱皮膚瘻の作製、胎盤表面血管の閉塞が可能なことも確認された。以上よりHIFUの低侵襲胎児治療への臨床応用の可能性が示された。

Research Products

• [Journal Article] Sequential changes in rat femoral artery blood flow and tissue degeneration after exposure to high-intensity focused ultrasound (2008)
  • Author(s): Tetsuya Ishikawa ,Takashi Okai,Kazuaki Sasaki,Shin-ichiro Umemura,Nozomi Miyazaki,Miki Kushima,Hiroko Aoki, Mitsuyoshi Ichihara,Kiyotake Ichizuka
  • Journal Title: Journal of Medical Ultrasonics 35 Pages: 177-182
  • NAID: 10025327588
  • Peer Reviewed
• [Journal Article] Sequential changes in rat femoral artery blood flow and tissue degeneration after exposure to high-intensity focused ultrasound (2008)
  • Author(s): Tetsuya Ishikawa
  • Journal Title: J. Med. Ultrasonics 35 Pages: 177-182
  • Peer Reviewed
• [Journal Article] 強出力集束超音波による子宮筋腫栄養血管閉塞による治療 (2008)
  • Author(s): 市塚清健
  • Journal Title: 臨床婦人科産科 62 Pages: 68-71
• [Journal Article] Application of high-intensity focused ultrasound for umbilical artery occlusion in a rabbit model (2007)
  • Author(s): Ichizuka K, Ando S, Ichihara M, Ishikawa T, Uchiyama N, Sasaki K, Umemura S, Matsuoka R, Sekizawa A, Okai T, Akabane T, Kushima M
  • Journal Title: Ultrasound Obstet Gynecol 30(1) Pages: 47-51
  • Peer Reviewed
• [Journal Article] Blood flow occlusion via ultrasound image-guided high-intensity focused ultrasound and its effect on tissue perfusion (2007)
  • Author(s): Ichihara M, Sasaki K, Umemura S, Kushima M, Okai T
  • Journal Title: Ultrasound Med Biol 33(3) Pages: 452-9
  • Peer Reviewed
• [Journal Article] Application of high-intensity focused ultrasound for umbilical artery occlusion in a rabbit model (2007)
  • Author(s): K. Ichizuka, T. Okai, et. al.
  • Journal Title: Ultrasound Obstet Gynecol 22(5) Pages: 358-360
  • Peer Reviewed
• [Journal Article] Blood flow occlusion via ultrasound image-guided high-intensity focused ultrasound and its effect on tissue perfusion. (2007)
  • Author(s): Ichihara M
  • Journal Title: Ultrasound Med Biol. Jan 5; (Epub ahead of print)
• [Journal Article] Effect of echo-guided high-intensity focused ultrasound ablation on localized experimental tumors (2006)
  • Author(s): Sasaki K, Medan MS, Azuma T, Kawabata K, Shimoda M, Umemura S
  • Journal Title: J Vet Med Sci 68(10) Pages: 1069-74
  • NAID: 110004820610
  • Peer Reviewed
• [Journal Article] 成育医療における胎児診療-無心体の治療- (2006)
  • Author(s): 市塚清健、松岡隆、大槻克文、下平和久、関沢明彦、岡井崇
  • Journal Title: 産科と婦人科 Vol.73(4) Pages: 477-481
• [Journal Article] Application of high-intensity focused ultrasound for fetal vascular occlusion : Potential for treatment of fetal diseases related to abnormal blood flow supply.
  • Author(s): Ichizuka K
  • Journal Title: Ultrasound Obstet Gynecol. (In press)
• [Presentation] Application of high-intensity focused ultrasound for fetal therapy-experimental study using animal model for obstructive uropathy- (2008)
  • Author(s): Kiyotake Ichizuka
  • Organizer: World congress on Ultrasound in Obstetrics and Gynec
  • Place of Presentation: シカゴ
  • Year and Date: 2008-08-28
• [Presentation] 超音波の安全対策-治療の立場から- (2008)
  • Author(s): 市塚清健
  • Organizer: 第81回日本超音波医学会学術集会ワークショップ
  • Place of Presentation: 神戸
• [Presentation] 強出力集束超音波による子宮筋腫の栄養血管閉塞による治療に向けての基礎的検討 (2007)
  • Author(s): 市塚清健
  • Organizer: 日本超音波医学会関東甲信越地方会第19回学術集会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-10
• [Presentation] Basic study of high-intensity focused ultrasound for fetal therapy (2007)
  • Author(s): Kiyotake Ichizuka
  • Organizer: 8^<th> Korea-Japan symposium of ultrasound in Obstetrics and gynecology
  • Place of Presentation: Jeju, Korea
  • Year and Date: 2007-10-20
• [Presentation] 強出力集束超音波(High-intensity focused ultrasound : HIFU)を用いた胎児腔水症・閉塞性尿路疾患の治療に向けての基礎的検討 (2007)
  • Author(s): 市塚清健
  • Organizer: 胎児治療学会
  • Place of Presentation: 大阪
  • Year and Date: 2007-10-19
• [Presentation] The study of reducing effect of tumor by ablation of the tumor-feeding artery using HIFU sonication : Potential for the therapy of uterine fibroid (2007)
  • Author(s): Kiyotake Ichizuka
  • Organizer: 10^<th> International symposium on therapeutic ultrasound
  • Place of Presentation: Seoul, Korea
• [Presentation] Application of high-intensity focused ultrasound for fetal therapy-experimental study using animal model- (2007)
  • Author(s): Kiyotake Ichizuka
  • Organizer: 8^<th> World Congress of Perinatal Medicine
  • Place of Presentation: Florence, Italy
• [Presentation] 子宮筋腫の発育制御とその管理強出力集束超音波(HIFU)を用いた栄養血管閉塞による子宮筋腫の低侵襲治療 (2007)
  • Author(s): 市塚清健
  • Organizer: 第59回日本産科婦人科学術講演会シンポジウム
  • Place of Presentation: 京都
• [Presentation] HIFUを用いた胎児腔水症・閉塞性尿路疾患の治療に向けての基礎的検討 (2007)
  • Author(s): 市塚 清健、岡井 崇, 他
  • Organizer: 胎児治療学会
  • Place of Presentation: 大阪
• [Presentation] 強出力集束超音波(HIFU)の胎児治療への応用に向けての基礎研究 (2006)
  • Author(s): 市塚清健
  • Organizer: 第4回日本胎児治療学会
  • Place of Presentation: 浜松