Development of a novel targeted single cell drug/gene delivery system
| Project/Area Number |
18200036
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical systems
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| Research Institution | Fukuoka University |
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Principal Investigator |
TACHIBANA Katsuro Fukuoka University, 医学部, 教授 (40271605)
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| Co-Investigator(Kenkyū-buntansha) |
AI Hiroyuki 福岡大学, 理学部, 助教 (20330897)
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| Project Period (FY) |
2006 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥41,730,000 (Direct Cost: ¥32,100,000、Indirect Cost: ¥9,630,000)
Fiscal Year 2008: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2007: ¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000)
Fiscal Year 2006: ¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000)
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| Keywords | 超音波エネルギー / 神経細胞 / 周波数 / 超小型超音波プローブ / 遺伝子導入 |
|---|
| Research Abstract |
本課題の目標であった超音波照射時における浮遊単細胞のリアルタイム顕微鏡観察システムを構築することができた。また、高速ビデオカメラにてマイクロバブルの挙動を観察すると同時に薬物が細胞内に流入する現象を初めてデジタル映像でとらえることができた。この顕微鏡システムを用いることで超音波の最適条件と各種のマイクロバブルの比較が可能となった。得られたデータ解析より、多種の細胞にこの技術が応用可能と考えられる。
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Report
(4 results)
Research Products
(62 results)
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[Journal Article] Biomolecular Effects of Low Intensity Ultrasound : Apoptosis, Sonotransfection, and Gene Expression2007
Author(s)
Feril LB Jr, Kondo T, Tabuchi Y, Ogawa R, Zhao Q-L, Nozaki T, Yoshida T, Kudo N, and Tachibana K
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Journal Title
Japanese Journal of Applied Physics 46(7B)
Pages: 4435-4440
Related Report
Peer Reviewed
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[Journal Article] Biomolecular Effects of Low Intensity Ultrasound: Apoptosis, Sonotransfection, and Gene Expression2007
Author(s)
Feril LB Jr, Kondo T, Tabuchi Y, Ogawa R, Zhao Q-L, Nozaki T, Yoshida T, Kudo N, and Tachibana K
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Journal Title
Japanese Journal of Applied Physics 46
Pages: 4435-4440
Related Report
Peer Reviewed
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[Journal Article] Biomolecular effects of low intensity ultrasound : apoptosis, sonotransfection, and gene expression.2007
Author(s)
Feril LB Jr, Kondo T, Tabuchi, Ogawa R, Zhao Q-L, Nozaki T, Toru Y, Kudo N, Tachibana K
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Journal Title
Japanese Journal of Applied Physics (in press)
Related Report
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[Presentation] 神経超音波の基礎2008
Author(s)
立花克郎
Organizer
第11回日本栓子検出と治療学会(エンボラス学会)
Place of Presentation
倉敷
Year and Date
2008-11-01
Related Report
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[Presentation] In vivo gene delivery by sonoporation with liposomal bubbles2007
Author(s)
Ryo Suzuki, Eisuke Nanami, yusuke Oda, Tomoko Takizawa, Naoki Utoguchi, Yoichi Negishi, Katsuro Tachibana, Kazuo Maruyama
Organizer
International Symposium on Sonochemistry and Sonoprocessing 2007-New horizonsin Sonochemistry and Sonoprocessing-
Place of Presentation
京都
Year and Date
2007-12-07
Related Report
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