Elucidation of molecular mechanisms of mental health improvement following a physical exercise and assembly of research resources

• Project/Area Number: 18200041
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Sports science
• Research Institution: National Institute of Fitness and Sports in Kanoya
• Principal Investigator: SHIBAYAMA Hidetaro National Institute of Fitness and Sports in Kanoya, 名誉教授 (00162644)
• Co-Investigator(Kenkyū-buntansha): TAKEKURA Hiroaki 鹿屋体育大学, 体育学部, 教授 (00206963) ; TAMAKI Hiroyuki 鹿屋体育大学, 体育学部, 准教授 (40253926) ; MIYACHI Motohiko 国立栄養・健康研究所, 運動ガイドラインプロジェクト, プロジェクトリーダー (60229870) ; MACHIDA Syuichi 東海大学, 体育学部, 准教授 (40421226) ; FUJIMOTO Toshihiko 東北大学, 高等教育開発推進センター, 講師 (00229048) ; SAKO Takayuki 日本女子大学, 家政学部, 講師 (20339477)
• Project Period (FY): 2006 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥48,360,000 (Direct Cost: ¥37,200,000、Indirect Cost: ¥11,160,000); Fiscal Year 2009: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000); Fiscal Year 2008: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000); Fiscal Year 2007: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000); Fiscal Year 2006: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
• Keywords: スポーツ生理学 / メンタルヘルス / 運動処方 / 自律神経機能 / 大脳皮質運動野 / 反応時間 / 経頭蓋磁気刺激 / 運動誘発電位 / 交感神経 / 骨 / 高血圧自然発症ラット / 6遮断薬 / 健康スポーツ科学 / 応用健康科学 / 体力医学 / 運動療法 / 動脈スティフネス / 慢性疲労 / 運動 / ACTH / 血流量 / 近赤外分光装置 / 前頭前野 / 一次運動野 / 運動誘発性ストレス / PET / 糖 / 前頭連合野 / 二次視覚野 / 思考 / 脳 / 最大酸素摂取量 / 乳酸 / 骨格筋 / 情動

Research Abstract

We investigated the elucidation of molecular and cellular mechanisms of the improvement effect of mental health following a physical exercise using experimental animal models and humans ; and we applied all these fundamental research resources to develop a specific exercise prescription program for mental health improvement. Long-term physical exercise training and transient exercise change the structural and functional profiles of nerve cells at motor cortex, and may cause the mental health improvement as a consequence.

Research Products

• [Journal Article] Effects of nonexhaustive bouts of high-intensity intermittent swimming training on GLUT-4 expression in rat skeletal muscle. (2010)
  • Author(s): Fujimoto, E., Machida, S., Higuchi, M., Tabata I.
  • Journal Title: J. Physiol. Sci. 60 Pages: 95-101
  • Peer Reviewed
• [Journal Article] Age and cardiorespiratory fitness are associated with arterial stiffening and left ventricular remodelling (2010)
  • Author(s): Gando, Y, 他12名
  • Journal Title: J.Human Hypertension 24 Pages: 197-206
  • Peer Reviewed
• [Journal Article] Effects of aerobic exercise training on brain structure and psychological well-being in young adults. (2009)
  • Author(s): Gondoh, H., Sensui, H., Kinomura, S., Fukuda, H., Fujimoto, T., Masud, M., Nagamatsu, T., Tamaki, H., Takekura, H.
  • Journal Title: J. Sports Med. Phys. Fitn. 49 Pages: 129-135
  • Peer Reviewed
• [Journal Article] Evaluation of individual skeletal muscle activity by glucose uptake during pedaling exercise at different workloads using positron emission tomography. (2009)
  • Author(s): Gondoh, Y., Tashiro, M., Itoh, M., Masud, M.M., Sensui, H., Watanuki, S., Ishi, K., Takekura, H., Nagatomi, R., Fujimoto, T.
  • Journal Title: J. Appl. Physiol. 107 Pages: 599-604
  • Peer Reviewed
• [Journal Article] Pulse wave velocity for assessment of arterial stiffness among people with spinal cord injury: a pilot study. (2009)
  • Author(s): Miyatani, M., Masani, K., Oh, P.I., Miyachi, M., Popovic, M.R., Craven, B.C.
  • Journal Title: J. Spinal Cord. Med. 32 Pages: 72-78
  • Peer Reviewed
• [Journal Article] Poor trunk flexibility is associated with arterial stiffening. (2009)
  • Author(s): Yamamoto, K., Kawano, H., Gando, Y., Iemitsu, M., Murakami, H., Sanada, K., Tanimoto, M., Ohmori, Y., Higuchi, M., Tabata, I., Miyachi, M.
  • Journal Title: Am. J. Physiol., Heart Circ Physiol. 297 Pages: 1314-1318
  • Peer Reviewed
• [Journal Article] Evaluation of individual skeletal muscle activity by glucose uptake during pwdaling exercise at different workloads using positoron emission to mography (2009)
  • Author(s): Gondoh, Y, 他9名
  • Journal Title: J.Appl.Physiol. 107 Pages: 599-604
  • Peer Reviewed
• [Journal Article] Effect of aerobic exercise trainig on brain structure and psychological well-being in young adults (2009)
  • Author(s): Gondo, Y., 他8名
  • Journal Title: J.Sports Med.Phys.Fitness 49 Pages: 129-135
  • Peer Reviewed
• [Journal Article] (2009)
  • Author(s): 竹倉宏明, 秋元良太
  • Journal Title: 筋細胞内情報伝達, 機構身体トレーニング, 運動生理学からみた身体機能の維持・向上(真興交易(株)医書出版部) Pages: 102-109
• [Journal Article] Pulse wave velocity for assessment of arterial stiffness among people with spinal cord injury : a pilot study (2009)
  • Author(s): Miyatani, M., 他5名
  • Journal Title: J. Spinal Cord Med. Pages: 72-78
  • Peer Reviewed
• [Journal Article] Age-related changes in two- and three-dimensional morphology of type-identified endplates in the rat diaphragm (2009)
  • Author(s): Suzuki T., 他4名
  • Journal Title: J. Physiol. Sci. 59 Pages: 57-62
  • Peer Reviewed
• [Journal Article] Differential cell death regulation between adult-unloaded and aged rat soleus muscle (2009)
  • Author(s): Ogata T., 他4名
  • Journal Title: Mech. Aging Develop. 130 Pages: 328-336
  • Peer Reviewed
• [Journal Article] Age-related changes in two- and three-dimensional morphology of type-identifiedendplates in the rat diaphragm. (2009)
  • Author(s): Suzuki, T., 他 4 名
  • Journal Title: J. Physiol. Sci. 59 Pages: 57-62
  • Peer Reviewed
• [Journal Article] Differential cell death regulation between adult-unloaded and aged rat soleus muscle. (2009)
  • Author(s): Ogata, T., 他 4 名
  • Journal Title: Mechanisms of Ageing Development 130 Pages: 328-336
  • Peer Reviewed
• [Journal Article] Pulse wave velocity for assessment of arterial stiffness among people with spinalcord injury : (2009)
  • Author(s): Miyatani, M., 他 5 名
  • Journal Title: J Spinal Cord Med. 32 Pages: 72-78
  • Peer Reviewed
• [Journal Article] Resistance training in men is associated with increased arterial stiffness and blood pressure but does not adversely affect endothelial function as measured by arterial reactivity to the cold pressor test. (2008)
  • Author(s): Kawano, H., Tanimoto, M., Yamamoto, K., Sanada, K., Gando, Y., Tabata, I., Higuchi, M., Miyachi, M.
  • Journal Title: Exp. Physiol. 93 Pages: 296-302
  • Peer Reviewed
• [Journal Article] Resistance training in men is associated with increased arterial stiffness and blood pressure but does not adversely affect endothelial function as measured by arterial reactivity to the cold pressor test. Exp (2008)
  • Author(s): Kawano, H., 他7名
  • Journal Title: Physiol. 93 Pages: 296-302
  • Peer Reviewed
• [Journal Article] 分子レベルからみた力学的ストレスに対する筋・骨格系の細胞応答. (2007)
  • Author(s): 町田修一, 岡本武志
  • Journal Title: 体育の科学 57 Pages: 357-364
  • Peer Reviewed
• [Journal Article] Resistance training in men is associated with increased arterial stiffness and blood pressure but does not adversely affect endothelial function as measured by arterial reactivity to the cold pressor test. (2007)
  • Author(s): Kawano, H., 他7名
  • Journal Title: Exp. Physiol. 93 Pages: 296-302
  • Peer Reviewed
• [Journal Article] 生活習慣病の発症機序と身体活動・運動:健康増進プログラム. (2007)
  • Author(s): 宮地元彦, 家光素行, 村上晴香
  • Journal Title: 体育の科学 57 Pages: 881-887
  • Peer Reviewed
• [Journal Article] HDLコレステロールをアップさせる運動療法. (2007)
  • Author(s): 家光素行、宮地元彦
  • Journal Title: 食生活 101 Pages: 30-36
  • Peer Reviewed
• [Journal Article] 歩行運動時のエネルギー消費量に及ぼす歩幅および歩調の影響. (2007)
  • Author(s): 佐古隆之
  • Journal Title: ウエルネスジャーナル (印刷中)
  • Peer Reviewed
• [Journal Article] 加齢性筋萎縮と骨格筋幹細胞. (2007)
  • Author(s): 町田修一
  • Journal Title: 基礎老化研究 31 Pages: 23-25
  • NAID: 10024377515
  • Peer Reviewed
• [Journal Article] 竹刀を用いた光刺激に対する引き技動作の筋電図反応時間及び打撃動作時間の分析. (2007)
  • Author(s): 與谷謙吾, 他6名
  • Journal Title: 生理人類学会誌 12 Pages: 139-146
  • Peer Reviewed
• [Journal Article] 剣道の引き面及び引き小手動作における上肢の反応時間と筋活動様式. (2007)
  • Author(s): 與谷謙吾, 田巻弘之, 荻田太, 桐本光, 北田耕司, 竹倉宏明
  • Journal Title: 鹿屋体育大学学術研究紀要 36 Pages: 33-40
  • NAID: 120006453054
  • Peer Reviewed
• [Journal Article] Assembly of transverse tubule architectures at middle and myotendinous junctional regions in developing rat skeletal muscle fiber. (2007)
  • Author(s): Yamashita, S., McGrath, K.F., Yuki, A., Tamaki, H., Kasuga, N., Takekura, H.
  • Journal Title: J. Muscle Res. Cell Motility 28 Pages: 141-151
  • Peer Reviewed
• [Journal Article] Effects of age on ventilatory threshold and peak oxygen uptake normalised for regional skeletal muscle mass in Japanese men and women aged 20-80 years. (2007)
  • Author(s): Sanada, K., Kuchiki, T., Miyachi, M., McGrath, K., Higuchi, M., Ebashi, H.
  • Journal Title: Eur. J. Appl. Physiol. 99 Pages: 475-483
• [Journal Article] 筋活動様式の違いが翌日の静的仕事に及ぼす影響. (2006)
  • Author(s): 田巻弘之, 北田耕司, 桐本光, 與谷謙吾, 荻田太, 竹倉宏明, 芝山秀太郎
  • Journal Title: 生理人類学雑誌 11 Pages: 19-24
  • Peer Reviewed
• [Journal Article] Bidirect signaling between calcium channels of skeletal muscle requires multiple direct and indirect interactions. (2006)
  • Author(s): Sheridan, D.C., Takekura, H., Franzini-Armstrong, C., Beam, K.G., Allen, P.D., Perez, C.F.
  • Journal Title: Proc. Natl. Acad. Sci. USA 103 Pages: 19760-19765
  • Peer Reviewed
• [Journal Article] Resistance training and arterial compliance: keeping the benefits while minimizing the stiffening. (2006)
  • Author(s): Kawano, H., Tanaka, H., Miyachi, M.
  • Journal Title: J. Hyperten. 24 Pages: 1753-1759
  • Peer Reviewed
• [Journal Article] Fluctuations in carotid arterial distensibility during the menstrual cycle do not influence cardiovagal baroreflex sensitivity. (2006)
  • Author(s): Hayashi, K., Miyachi, M., Seno, N., Takahashi, K., Yamazaki, K., Sugawara, J., Yokoi, T., Onodera, S., Mesaki, N.
  • Journal Title: Acta Physiol 86 Pages: 103-110
  • Peer Reviewed
• [Journal Article] Bidirect signaling between calcium channels of skeletal muscle requires multiple direct and indirect interactions (2006)
  • Author(s): Sheridan, D.C., 他5名
  • Journal Title: Proc. Natl. Acad. Sci.USA, reviewed 103 Pages: 19760-19765
  • Peer Reviewed
• [Journal Article] Central circulatory and peripheral O(2) extraction changes as interactive facilitators of pulmonary O(2) uptake during a repeated high-intensity exercise protocol in humans. (2006)
  • Author(s): Fukuda, Y., Endo, M.Y., Ohe, Y., Hirotoshi, Y., Kitano, A., Shiragiku, C., Miura, A., Fukuda, O., Ueoka, H., Miyachi, M.
  • Journal Title: Eur. J. Appl. Physiol. 99 Pages: 361-369
• [Journal Article] Plasticity of neuromuscular junction architectures in rat slow and fast muscle fibers following temporary denervatin and reinnervation processes. (2006)
  • Author(s): Nishizawa, T., Yamashita, S., McGrath, K.F., Tamaki, H., Kasuga, N., Takekura, H.
  • Journal Title: J. Muscle Res. Cell Motil. 27 Pages: 607-615
• [Journal Article] Histomorphological evidence of muscle tissue damage and recording area using coiled and straight intramuscular wire electrodes. (2006)
  • Author(s): Tamaki, H., Murata, F., Takekura, H.
  • Journal Title: Eur. J. Appl. Physiol. 98 Pages: 323-327
• [Journal Article] 1ヶ月間低強度運動トレーニングによる肥満者の脂質代謝促進効果. (2006)
  • Author(s): 江崎和希, 谷代一哉, 佐古隆之, 大久保正樹, 桑森真介, 他
  • Journal Title: 運動・物理療法 17 Pages: 248-254
• [Presentation] 短時間低強度運動が計算作業量および脳血流動態に及ぼす影響. (2009)
  • Author(s): 佐古隆之, 竹倉宏明
  • Organizer: 体力科学
• [Presentation] 経頭蓋磁気刺激を用いた視覚-運動関連時間の同定と反応トレーニングの効果. (2009)
  • Author(s): 與谷謙吾, 坂下一平, 行方功史, 河原一仁, 幸篤武, 北田耕司, 桐本光, 田巻弘之, 荻田太, 竹倉宏明
  • Organizer: 体力科学
• [Presentation] 筋再生の分子メカニズムと老化制御 (2009)
  • Author(s): 町田修一
  • Organizer: 第64回日本体力医学会大会シンポジウム
  • Place of Presentation: 新潟県, 新潟市
• [Presentation] 生活習慣病予防と最大酸素摂取量-「運動基準2006」の策定- (2009)
  • Author(s): 宮地元彦
  • Organizer: 第64回日本体力医学会大会シンポジウム
  • Place of Presentation: 新潟県, 新潟市
• [Presentation] 若年者における有酸素能力と脳構造の関係 (2008)
  • Author(s): 権藤雄一, 泉水宏臣, 藤本敏彦, 永松俊哉, 竹倉宏明
  • Organizer: 体力科学
• [Presentation] 計算課題中の前頭葉前額部血流動態に及ぼす短時間低強度運動の影響. (2008)
  • Author(s): 佐古隆之, 竹倉宏明, 芝山秀太郎
  • Organizer: 体力科学
• [Presentation] The impaired inflammatory response to muscle damage contributes to the impaired muscle regenerative capacity and to increased muscle adiposity with aging (2008)
  • Author(s): Machida, S., Okamoto T.
  • Organizer: The Integrative Biology of Exercise V
  • Place of Presentation: South Carolina, USA
• [Presentation] Alterations of trabecular bone architecture and muscle atrophy after sciatic neurectomy in rat proximal tibiae (2008)
  • Author(s): Tamaki, H., 他3名
  • Organizer: 12^<th> Annual Congress ECSS
  • Place of Presentation: Jyvaskyla, Finland
• [Presentation] 計算課題中の前頭葉前額部血流動態に及ぼす短時間低強度運動の影響 (2008)
  • Author(s): 佐古隆之, 竹倉宏明, 芝山秀太郎
  • Organizer: 第63回日本体力医学会大会
  • Place of Presentation: 大分県, 別府市
• [Presentation] The impaired inflammatory response to muscle damage contributes to the impairedmuscle regenerative capacity and to increased muscle adiposity with aging. (2008)
  • Author(s): Machida, S., Okamoto, T.
  • Organizer: Integrative Biology of Exercise V
  • Place of Presentation: South Carolina, USA
• [Presentation] PETを用いた高強度運動後の脳内セロトニン神経活動の観察. (2007)
  • Author(s): 藤本敏彦, 永松俊哉, 泉水弘臣, 菊地次郎, 小川静香, 石井賢治, 千葉登, 永富良一, 権藤雄一, 竹倉宏明
  • Organizer: 体力科学56
• [Presentation] 有酸素トレーニングによる脳構造と精神的健康度への影響. (2007)
  • Author(s): 権藤雄一, 泉水弘臣, 藤本敏彦, 永松俊哉, 竹倉宏明
  • Organizer: 体力科学
• [Presentation] Poor flexibility is associated with arterial stiffening. (2007)
  • Author(s): Yamamoto, K., Kawano, H., Gando, Y., Sanada, K., Tanimoto, M., Oh, T., Ohmori, Y., Higuchi, M., Tabata, I., Miyachi, M.
  • Organizer: 54th ACSM
  • Place of Presentation: New Orleans, Louisiana, USA
• [Presentation] Greater age-related arterial stiffening and left ventricular hypertrophy in poor cardiorespiratory fitness women. (2007)
  • Author(s): Gando, Y., Miyachi, M., Kawano, H., Sanada, K., Yamamoto, K., Tanimoto, M., Oh, T., Ohmori, Y., Miyatani, M., Usui., C., Takahashi, E., Tabata, I., Higuchi, M.
  • Organizer: 54th ACSM
  • Place of Presentation: New Orleans, Louisiana, USA
• [Presentation] Regeneration of aging skeletal muscle is associated with impaired inflammation and increased adipogenesis (2007)
  • Author(s): Machida, S.
  • Organizer: 12th ECSS, JSPFSM Exchange Symposium
  • Place of Presentation: Jyvaskyla, Finland
• [Presentation] Poor flexibility is associated with Arterial Stiffening (2007)
  • Author(s): Yamamoto, K., 他9名
  • Organizer: ACSM 54^<th> Annual Meeting
  • Place of Presentation: New Orleans, USA.
• [Presentation] A novel form of retrograde signaling between RyR3 and the DHPR in skeletal muscle (2007)
  • Author(s): Sheridan, D.C., 他5名
  • Organizer: 51^<st> Annual Meering of the Biophysical Society
  • Place of Presentation: Baltimore, USA.
• [Presentation] 高齢期骨格筋幹細胞(筋サテライト細胞)の細胞内情報伝達系の特徴, (2007)
  • Author(s): 町田修一
  • Organizer: 第30回日本基礎老化学会
  • Place of Presentation: 札幌市
• [Presentation] Regeneration of aging skeletal muscle is associated with impaired inflammation and increased adipogenesis. (2007)
  • Author(s): Machida, S.
  • Organizer: 12th Annual Congress ECSS
  • Place of Presentation: Jyvaskyla, Finland
• [Presentation] Serotonin release of frontal cortex in human brain after high intensity exercise. (2007)
  • Author(s): Fujimoto, T., 他12名
  • Organizer: 12th Annual Congress ECSS
  • Place of Presentation: Jyvaskyla, Finland
• [Presentation] Alterations of trabecular bone architecture and muscle atrophy after sciatic neurectomy in rat proximal tibiae. (2007)
  • Author(s): Tamaki, H., Yotani, K., Ogita, F., Takekura, H.
  • Organizer: 12th Annual Congress ECSS
  • Place of Presentation: Jyvaskyla, Finland
• [Presentation] The effect of exercise training on grau matter structure of adult human brain. (2007)
  • Author(s): Sensui, H., Gondo, Y., Nagamatsu, T., Takekura, H., Fujimoto, T.
  • Organizer: 12th Annual Congress ECSS
  • Place of Presentation: Jyvaskyla, Finland
• [Presentation] Plasticity of neuromuscular junction architectures following temporary denervation and BPVC injection in rat skeletal muscle fibers. (2007)
  • Author(s): Nishizawa, T., Yuki, A., Tamaki, H., Takekura, H.
  • Organizer: 12th Annual Congress ECSS
  • Place of Presentation: Jyvaskyla, Finland
• [Presentation] 脱分極刺激に伴う筋細胞のT管形態変化の可逆性と興奮収縮連関の機能発現様式. (2007)
  • Author(s): 竹倉宏明, McGrath, K., 山下晋, 田巻弘之, 西沢富江, 春日規克
  • Organizer: 第62回日本体力医学会大会
  • Place of Presentation: 秋田市
• [Presentation] PETを用いた高強度運動後の脳内セロトニン神経活動の観察. (2007)
  • Author(s): 藤本敏彦, 他9名
  • Organizer: 第62回日本体力医学会大会
  • Place of Presentation: 秋田市
• [Presentation] 計算課題中の局所血流量増加に及ぼす運動の影響. (2007)
  • Author(s): 佐古隆之, 竹倉宏明, 芝山秀太郎
  • Organizer: 第62回日本体力医学会大会
  • Place of Presentation: 秋田市
• [Presentation] 坐骨神経凍結麻痺法を用いた一過性の下肢不活動によるラット脛骨骨梁の構造的可逆性. (2007)
  • Author(s): 田巻弘之, 與谷謙吾, 荻田太, 竹倉宏明, 北田耕司, 桐本光, 幸篤武
  • Organizer: 第62回日本体力医学会大会
  • Place of Presentation: 秋田市
• [Presentation] 筋力トレーニング者における局所的寒冷刺激に対する頸動脈径の反応性. (2007)
  • Author(s): 河野寛, 他8名
  • Organizer: 第62回日本体力医学会大会
  • Place of Presentation: 秋田市
• [Presentation] The relation between hippocampal structure and psychological well-being in exercising and non-exercising students. (2006)
  • Author(s): Fujimoto, T., Sensui, H., Takekura, H., Gondo, Y., Ono, Y., Ogawa, S., Kikuchi, J., Kinomura, S., Tashiro, M., Itoh, M., Nagamatsu, T., Nagatomi, R.
  • Organizer: 11th ECSS
  • Place of Presentation: Lausanne, Switzerland
• [Presentation] Relation between hippocampal structure and psychological well-being in exercising and non-exercising students (2006)
  • Author(s): Fujimoto, T., 他10名
  • Organizer: 11h Annual Congress ECSS
  • Place of Presentation: Lausanne, Switzerland
• [Book] 筋細胞内情報伝達機構. 宮村実晴編集, 身体トレーニング (2009)
  • Author(s): 竹倉宏明, 秋元良太
  • Publisher: 真興交易医書出版部
• [Book] サルコペニアモデル動物の評価, 老化・老年病研究のための動物実験ガイドブック. (2008)
  • Author(s): 町田修一
  • Publisher: 日本基礎老化学会編
• [Book] 日本基礎老化学会編, アドスリー (2008)
  • Author(s): 町田修一(分担執筆)
  • Publisher: サルコペニアモデル動物の評価, 老化・老年病研究のための動物実験がイドブック
• [Book] Homeostatic control of whole-body energy metabolism by exercise: A positron emission tomography study (2007)
  • Author(s): Masud, M., Fujimoto, T., Tashiro, M., Miyake, M., Watanuki, S., Itoh, M., Esashi, M., et. al.
  • Publisher: Future medical engineering based on bionanotechnology
• [Book] Homeostatic control of whole-body energy metabolism by exercise: A positron emission tomography study.: in Future medical engineering based on bionanotechnology. (2007)
  • Author(s): Masud, M., 他5名
  • Total Pages: 769
  • Publisher: Imperial College Press