Studies on roles of translesion DNA synthesis in thresholds for genotoxic substances

• Project/Area Number: 18201010
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Risk sciences of radiation/Chemicals
• Research Institution: National Institute of Health Sciences
• Principal Investigator: NOUMI Takehiko National Institute of Health Sciences, 変異遺伝部, 部長 (30150890)
• Co-Investigator(Kenkyū-buntansha): MASUMURA Kenichi 国立医薬品食品衛生研究所, 変異遺伝部, 主任研究官 (40291116)
• Project Period (FY): 2006 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥52,000,000 (Direct Cost: ¥40,000,000、Indirect Cost: ¥12,000,000); Fiscal Year 2009: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2008: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000); Fiscal Year 2007: ¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000); Fiscal Year 2006: ¥26,000,000 (Direct Cost: ¥20,000,000、Indirect Cost: ¥6,000,000)
• Keywords: トキシコロジー / 遺伝毒性の閾値 / 有害化学物質 / 遺伝子 / 環境 / 癌

Research Abstract

DNA polymerase kappa (Polκ) is an enzyme involved in DNA synthesis across DNA lesions (translesion DNA synthesis). We identified important amino acids involved in the translesion DNA synthesis and generated human cells and mice, whose Polκ activities were inactivated by specific amino acids substitutions. The results suggest that translesion DNA synthesis may be one of mechanisms underlying practical thresholds for genotoxicity. An international symposium on genotoxic and carcinogenic thresholds has been organized.

Research Products

• [Journal Article] Critical amino acids in human DNA polymerasesηandκinvolved in erroneous incorporation of oxidized nucleotides (2010)
  • Author(s): A. Katafuchi, A. Sassa, N. Niimi, P. Gruz, H. Fujimoto, C. Masutani, F. Hanaoka, T. Ohta, T. Nohmi
  • Journal Title: Nucleic Acids Res. 38 Pages: 859-867
• [Journal Article] Dynamic bypass of a major cisplatin-DNA adduct revealed in structural, kinetic and in vivo studies (2010)
  • Author(s): J.H.Y.Wong
  • Journal Title: EMBO Journal (印刷中)
  • Peer Reviewed
• [Journal Article] Integration of in vivo genotoxicity and short-term carcinogenicity assays using F344 gpt delta transgenic rats : in vivo mutagenicity of 2, 4-diaminotoluene and 2, 6-diaminotoluene structural isomers (2010)
  • Author(s): N.Toyoda-Hokaiwado
  • Journal Title: Toxicol.Sci. 114 Pages: 71-78
  • Peer Reviewed
• [Journal Article] Critical amino acids in human DNA polymerases eta and kappa involved in erroneous incorporation of oxidized nucleotides (2010)
  • Author(s): A.Katafuchi
  • Journal Title: Nucleic Acids Res. 38 Pages: 859-867
  • Peer Reviewed
• [Journal Article] Radiation dose-rate effect on mutation induction in spleen and liver of gpt delta mice (2010)
  • Author(s): N.Okudaira
  • Journal Title: Radiat.Res. 173 Pages: 138-147
  • Peer Reviewed
• [Journal Article] The steric gate amino acid tyrosine 112 is required for efficient mismatched-primer extension by human DNA polymeraseκ (2009)
  • Author(s): N. Niimi, A. Sassa, A. Katafuchi, P. Gruz, H. Fujimoto, R.R. Bonala, F. Johnson, T. Ohta, T. Nohmi
  • Journal Title: Biochem. 48 Pages: 4239-4246
• [Journal Article] Spontaneous mutagenesis in rodents: spontaneous gene mutations identified by neutral reporter genes in gpt delta transgenic mice and rats (2009)
  • Author(s): K. Masumura, T. Nohmi
  • Journal Title: J. Health Sci. 55 Pages: 40-49
  • NAID: 110007055908
• [Journal Article] Genotoxicity of nano/microparticles in in vitro micronuclei, in vivo comet and mutation assay systems (2009)
  • Author(s): Y.Totsuka
  • Journal Title: Part Fibre.Toxicol. 6 Pages: 23-33
  • Peer Reviewed
• [Journal Article] Alteration of genome structure induced by very low dose-rate irradiation in mouse tissue (2009)
  • Author(s): T.Ono
  • Journal Title: Data Science Journal 8
  • Peer Reviewed
• [Journal Article] Translesional DNA synthesis through a C8-guanyl adduct of 2-amino-1-methyl-6-phenylimidazo[4, 5-b]pyridine(PhIP)in Vitro : Revl inserts dc opposite the lesion and DNA polymerase kappa potentially catalyzes extension reaction from the 3'-dc terminus (2009)
  • Author(s): H.Fukuda
  • Journal Title: J.Biol.Chem. 284 Pages: 25585-25592
  • Peer Reviewed
• [Journal Article] Genetic analysis of repair and damage tolerance mechanisms for DNA-protein crosslinks in Escherichia coli (2009)
  • Author(s): A.M.Salem
  • Journal Title: J.Bacteriol. 191 Pages: 5657-5668
  • Peer Reviewed
• [Journal Article] Development of tester strains deficient in Nth/Nei DNA glycosylases to selectively detect the mutaenicity of oxidized DNA pyrimidines (2009)
  • Author(s): M.Yamada
  • Journal Title: Genes and Environ. 31 Pages: 69-79
  • Peer Reviewed
• [Journal Article] Inhibition of translesion DNA polymerase by archaeal reverse gyrase (2009)
  • Author(s): A.Valent
  • Journal Title: Nucleic Acids Res. 37 Pages: 4287-4295
  • Peer Reviewed
• [Journal Article] Improvement and evaluation of high throughput fluctuation Ames test using 384-well plate with salmonella typhimurium TA100 and TA98 (2009)
  • Author(s): H.Sui
  • Journal Title: Genes and Environ. 31 Pages: 47-55
  • Peer Reviewed
• [Journal Article] The steric gate amino acid tyrosine 112 is required for efficient mismatched-primer extension by human DNA polymerase κ (2009)
  • Author(s): N.Niimi
  • Journal Title: Biochem. 48 Pages: 4239-4246
  • Peer Reviewed
• [Journal Article] Mutagenicity tesing for chemical risk assessment (2009)
  • Author(s): D.A.Eastmond
  • Journal Title: Mutagenesis 24 Pages: 341-349
  • Peer Reviewed
• [Journal Article] The steric gate amino acid tyrosine 112 is required for efficient (2009)
  • Author(s): N. Niim, A. Sassa, A. Katafuchi, P. Gruz, H. Fujimoto, R.R. Bonala, F. Johnson, T. Ohta, and T. Nohmi
  • Journal Title: mismatched-primer extension by human DNA polymerase k, Biochem 48 Pages: 4329-4246
• [Journal Article] Spontaneous mutagenesis in rodents : spontaneous gene mutations identified by neutral reporter genes in gpt delta transgenic mice and rats (2009)
  • Author(s): K. Masumura, T. Nohmi
  • Journal Title: J. Health Sci 55 Pages: 40-49
  • NAID: 110007055908
• [Journal Article] Inhibition of translesion DNA polymerase by archaeal reverse gyrase (2009)
  • Author(s): A. Valent
  • Journal Title: Nucleic Acids Research 印刷中(印刷中)
  • Peer Reviewed
• [Journal Article] Improvement and evaluation of high throughput fluctuation Ames test using 384-well plate with Salmonella typhimurium TA100 and TA98 (2009)
  • Author(s): H. Sui
  • Journal Title: Genes and Environment 印刷中(印刷中)
  • Peer Reviewed
• [Journal Article] The steric gate amino acid tyrosine 112 is required for efficient mismatched-primer extension by human DNA polymerase κ (2009)
  • Author(s): N. Niimi
  • Journal Title: Biochemistry 印刷中(印刷中)
  • Peer Reviewed
• [Journal Article] Mutagenicity testing for chemical risk assessment (2009)
  • Author(s): D. A. Eastmond
  • Journal Title: Mutagenesis 印刷中(印刷中)
  • Peer Reviewed
• [Journal Article] DinB up-regulation is the sole role of the SOS response in stress-induced mutagenesis in Escherichia coli (2009)
  • Author(s): R. S. Galhardo
  • Journal Title: Genetics 182 Pages: 55-68
  • Peer Reviewed
• [Journal Article] Role of Parp-1 in suppressing spontaneous deletion mutation in the liver and brain of mice at adolescence and advanced age (2009)
  • Author(s): A. Shibata
  • Journal Title: Mutation Research 664 Pages: 20-27
  • Peer Reviewed
• [Journal Article] Genotoxic responses to titanium dioxide nanoparticles and fullerene in gpt delta transgenic MEF cells (2009)
  • Author(s): A. Xu
  • Journal Title: Particle and Fibre. Toxicology 6 Pages: 3-15
  • Peer Reviewed
• [Journal Article] in vivo mutagenesis caused by diesel exhaust in the testis of gpt delta transgenic mice (2009)
  • Author(s): A. H. Hashimoto
  • Journal Title: Genes and Environment 31 Pages: 1-8
  • Peer Reviewed
• [Journal Article] Possible participation of oxidative stress in causation of cell proliferation and in vivo mutagenicity in kidneys of gpt delta rats treated with potassium bromate (2009)
  • Author(s): T. Umemura
  • Journal Title: Toxicology 257 Pages: 46-52
  • Peer Reviewed
• [Journal Article] Spontaneous mutagenesis in rodents : spontaneous gene mutations identified by neutral reporter genes in gpt delta transgenic mice and rats (2009)
  • Author(s): K. Masumura
  • Journal Title: Journal of Health Science 55 Pages: 40-49
  • NAID: 110007055908
  • Peer Reviewed
• [Journal Article] International symposium on genotoxic and carcinogenic thresholds (2009)
  • Author(s): T. Nohmi
  • Journal Title: Genes and Environment 30 Pages: 101-107
  • Peer Reviewed
• [Journal Article] Possible mechanisms of practical thresholds for genotoxicity (2009)
  • Author(s): T. Nohmi
  • Journal Title: Genes and Environment 30 Pages: 108-113
  • Peer Reviewed
• [Journal Article] in vivo approaches to study mechanism of action of genotoxic carcinogens (2009)
  • Author(s): A. Nishikawa
  • Journal Title: Genes and Environment 30 Pages: 120-124
  • Peer Reviewed
• [Journal Article] Possible mechanisms of practical thresholds for genotoxicity (2008)
  • Author(s): T. Nohmi
  • Journal Title: Genes and Environ. 30 Pages: 108-113
• [Journal Article] International symposium on genotoxic and carcinogenic thresholds (2008)
  • Author(s): T. Nohmi, N. Toyoda-Hokaiwado, M. Yamada, K. Masumura, M. Honma, S. Fukushima
  • Journal Title: Genes and Environ. 30 Pages: 101-107
  • NAID: 110007007982
• [Journal Article] Specificity of mutations induced by incorporation of oxidized dNTPs into DNA by human DNA polymeraseη (2008)
  • Author(s): K. Hidaka, M. Yamada, H. Kamiya, C. Masutani, H. Harashima, F. Hanaoka, T. Nohmi
  • Journal Title: DNA Repair 7 Pages: 497-506
• [Journal Article] Possible mechanisms of practical thresholds for genotoxicity (2008)
  • Author(s): T. Nohmi
  • Journal Title: Genes and Environ 30 Pages: 108-113
• [Journal Article] Overproduction of Escherichia coli DNA polymerase DinB (Pol IV) in hibits replication fork progression and is lethal (2008)
  • Author(s): K. Uchida
  • Journal Title: Molecular Microbiology 70 Pages: 608-622
  • Peer Reviewed
• [Journal Article] Arabidopsis thaliana Y family DNA polymerase eta catalyses translesion synthesis and interacts functionally with PCNA2 (2008)
  • Author(s): H. Anderson
  • Journal Title: The Plant Journal 55 Pages: 895-908
  • Peer Reviewed
• [Journal Article] Miscoding properties of 2'-deoxyinosine,a nitric oxide-derived DNA adduct,during translesion synthesis catalyzed by human DNA polymerases (2008)
  • Author(s): M.Yasui
  • Journal Title: J.Mol.Boil. 37 Pages: 1015-1023
  • Peer Reviewed
• [Journal Article] Specificity of mutations induced by incorporation of oxidized dNTPs into DNA by human DNA polymerase η (2008)
  • Author(s): K.Hidaka
  • Journal Title: BNA Repair 7 Pages: 497-506
  • Peer Reviewed
• [Journal Article] Differential effects oflow-and high-dose X-rays on N-ethyl-N-nitrosourea-induced mutagenesis in thymocytes of B6C3F1 gpt-delta mice (2008)
  • Author(s): K.Yamauchi
  • Journal Title: Mutat.Res. 640 Pages: 27-37
  • Peer Reviewed
• [Journal Article] Enhanced spontaneous and benzo(a)pyrene-induced mutations in the lung of Nrf2-deficient gpt delta mice (2007)
  • Author(s): Y. Aoki, A.H. Hashimoto, K. Akanuma, M. Matsumoto, K. Hiyoshi, H. Takano, K. Masumura, K. Itoh, T. Nohmi, M. Yamamoto
  • Journal Title: Cancer Res. 67 Pages: 5643-5648
• [Journal Article] Novel DNA polymerases and novel genotoxicity assays (2007)
  • Author(s): T. Nohmi
  • Journal Title: Genes and Environ. 29 Pages: 75-88
• [Journal Article] Efficient and erroneous incorporation of oxidized DNA precursors by human DNA polymeraseη (2007)
  • Author(s): M. Shimizu, P. Gruz, H. Kamiya, C. Masutani, Y. Xu, Y. Usui, H. Sugiyama, H. Harashima, F. Hanaoka, T. Nohmi
  • Journal Title: Biochem. 46 Pages: 5515-5522
• [Journal Article] Mutations in the lungs of gpt delta transgenic mice following inhalation of diesel exhaust (2007)
  • Author(s): A.H.Hashimoto
  • Journal Title: Environ.Mol.Mutagen. 48 Pages: 682-693
  • Peer Reviewed
• [Journal Article] Detection of oxidative DNA damage,cell proliferation and in vivo mutagenicity induced by dicyclanil,a non-genotoxic carcinogen,using gpt delta mice (2007)
  • Author(s): T.Umemura
  • Journal Title: Mutat.Res. 633 Pages: 46-54
  • Peer Reviewed
• [Journal Article] Enhanced spontaneous and benzo(a)pyrene-induced mutations in the lung of Nrf2-deficient gpt delta mice (2007)
  • Author(s): Y.Aoki
  • Journal Title: Cancer Res. 67 Pages: 5643-5648
  • Peer Reviewed
• [Journal Article] Mutation spectra in cisplatin-and transplatin-treated GDL1 cells clarified the different mode of action of these compounds in mammalian cells (2007)
  • Author(s): A.Takeiri
  • Journal Title: Genes and Environ. 29 Pages: 89-99
  • Peer Reviewed
• [Journal Article] Efficient and erroneous incorporation of oxidized DNA precursors by human DNA polymerase η (2007)
  • Author(s): M.Shimizu
  • Journal Title: Biochem. 46 Pages: 5515-5522
  • Peer Reviewed
• [Journal Article] Replication of 2-hydroxyadenine-containing DNA substrates and recognition by human MutS alpha (2007)
  • Author(s): F.Barone
  • Journal Title: DNA Repair 6 Pages: 355-366
  • Peer Reviewed
• [Journal Article] Biochemical evidence of a physical interaction between Sulfolobus solfataricus B-family and Y-family DNA polymerases (2007)
  • Author(s): M.DeFelice
  • Journal Title: Extremophiles 11 Pages: 277-282
  • Peer Reviewed
• [Journal Article] New insight into intrachromosomal deletions induced by chrysotile in gpt delta transgenic (2007)
  • Author(s): A.Xu
  • Journal Title: Environ.Health Perspective 115 Pages: 87-92
  • Peer Reviewed
• [Journal Article] Combined genotoxic effects of radiation and a tobacco-specific nitrosamine in the lung of gpt delta transgenic mice (2007)
  • Author(s): M.Ikeda
  • Journal Title: Mutat. Res. 626 Pages: 15-25
  • Peer Reviewed
• [Journal Article] Lack of in vivo mutagenicity and oxidative DNA damage by flumequine in the livers of gpt delta mice (2007)
  • Author(s): Y.Kuroiwa
  • Journal Title: Arch.Toxicol. 81 Pages: 63-69
  • Peer Reviewed
• [Journal Article] Novel DNA polymerases and novel genotoxicity assays (2007)
  • Author(s): T.Nohmi
  • Journal Title: Genes and ENviron. 29 Pages: 75-88
  • Peer Reviewed
• [Journal Article] Report of the IWGT working group on strategies and interpretation of regulatory in vivo tests I.Increases in micronucleated bone marrow cells in rodents that do not indicate genotoxic hazards (2007)
  • Author(s): D.J.Tweats
  • Journal Title: Mutat.Res. 209 Pages: 78-91
  • Peer Reviewed
• [Journal Article] Report of the IWGT working group on strategies and interpretation of regulatory in vivo tests II.Identification of in vivo-only positive compounds in the bone marrow micronucleus test (2007)
  • Author(s): D.J.Tweats
  • Journal Title: Mutat.Res. 29 Pages: 92-105
  • Peer Reviewed
• [Journal Article] Replication of 2-hydroxyadenine-containing DNA substrates and recognition by human MutSα (2007)
  • Author(s): F.Barone et al.
  • Journal Title: DNA Repair 6 Pages: 356-366
• [Journal Article] Biochemical evidence of a physical interaction between Sulfolobus solfataricus B-family and Y-family DNA polymerases (2007)
  • Author(s): M.De Felice et al.
  • Journal Title: Extremophiles 11 Pages: 277-282
• [Journal Article] New insight into intrachromosomal deletions induced by chrysotile in gpt delta transgenic (2007)
  • Author(s): A.Xu et al.
  • Journal Title: Environ. Health Perspective 115 Pages: 87-92
• [Journal Article] Combined genotoxic effects of radiation and a tobacco-specific nitrosamine in the lung of gpt delta transgenic mice (2007)
  • Author(s): M.Ikeda et al.
  • Journal Title: Mutat. Res. 626 Pages: 15-25
• [Journal Article] Lack of in vivo mutagenicity and oxidative DNA damage by flumequine in the livers of gpt delta mice (2007)
  • Author(s): Y.Kuroiwa et al.
  • Journal Title: Arch. Toxicol. 81 Pages: 63-69
• [Journal Article] Report of the IWGT working group on strategies and interpretation of regulatory in vivo tests I. Increases in micronucleated bone marrow cells in rodents that do not indicate genotoxic hazards (2007)
  • Author(s): D.Tweats et al.
  • Journal Title: Mutat. Res. 627 Pages: 78-91
• [Journal Article] Report of the IWGT working group on strategy/interpretation for regulatory in vivo tests II. Identification of in vivo-only positive compounds in the bone marrow micronucleus test (2007)
  • Author(s): D.Tweats et al.
  • Journal Title: Mutat. Res. 627 Pages: 92-105
• [Journal Article] Environmental stress and lesion-bypass DNA polymerases (2006)
  • Author(s): T. Nohmi
  • Journal Title: Ann. Rev. Microbiol. 60 Pages: 231-253
• [Journal Article] Involvement of Y-family DNA polymerases in mutagenesis caused by oxidized nucleotides in Escherichia coli (2006)
  • Author(s): M. Yamada, T. Nunoshiba, M. Shimizu, P. Gruz, H. Kamiya, H. Harashima, T. Nohmi
  • Journal Title: J. Bacteriol. 188 Pages: 4992-4995
• [Journal Article] Specificity of replicative and SOS-inducible DNA polymerases in frameshift mutagenesis: Mutability of Salmonella typhimurium strains overexpressing SOS-inducible DNA polymerases to 30 chemical mutagens (2006)
  • Author(s): K. Matsui, M. Yamada, M. Imai, K. Yamamoto, T. Nohmi
  • Journal Title: DNA Repair 5 Pages: 465-478
• [Journal Article] Environmental stress and lesion-bypass DNA polymerases (2006)
  • Author(s): T. Nohmi
  • Journal Title: Ann. Rev. Microbiol 60 Pages: 231-253
• [Journal Article] in vivo mutagenicity and initiation following oxidative DNA lesion in the kidneys of rats given potassium bromate (2006)
  • Author(s): T.Uemura et al.
  • Journal Title: Cancer Sci. 97 Pages: 829-835
• [Journal Article] Environmental stress and lesion-bypass DNA polymerases (2006)
  • Author(s): T.Nohmi
  • Journal Title: Ann. Rev. Microbiol. 60 Pages: 231-253
• [Journal Article] A newly established GDL1 cell line from gpt delta well reflects the in vivo mutation spectra induced by mitomycin C (2006)
  • Author(s): T.Takeiri et al.
  • Journal Title: Mutat. Res. 609 Pages: 102-115
• [Journal Article] Deletion and single nucleotide substitution at G : C in the kidney of gpt delta transgenic mice after ferric nitrilotriacetate treatment (2006)
  • Author(s): L.Jiang
  • Journal Title: Cancer Sci. 97 Pages: 1159-1167
• [Journal Article] Chemopreventive effects of nobiletin against genotoxicity induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in the lung of gpt delta transgenic mice (2006)
  • Author(s): M.Ikeda et al.
  • Journal Title: Genes and Environ. 28 Pages: 84-91
• [Journal Article] Involvement of Y-family DNA polymerases in mutagenesis caused by oxidized nucleotides in Escherichia coli (2006)
  • Author(s): M.Yamada et al.
  • Journal Title: J. Bacteriol. 188 Pages: 4992-4995
• [Journal Article] IL-10 deficiency leads to somatic mutations in a model of IBD (2006)
  • Author(s): Y.Sato et al.
  • Journal Title: Carcinogenesis 27 Pages: 1068-1073
• [Journal Article] Inhibitory effects of caraway (Carum carvi L.) and its component on N-methyl-N'-nitro-N-nitrosoguanidine-induced mutagenicity (2006)
  • Author(s): M.Mazaki et al.
  • Journal Title: J. Med. Invest. 53 Pages: 123-133
• [Journal Article] in vivo mutagenesis in the lungs of gpt-delta transgenic mice treated intratracheally with 1,6-dinitropyrene (2006)
  • Author(s): A.H.Hashimoto et al.
  • Journal Title: Environ. Mol. Mutagen. 47 Pages: 277-283
• [Journal Article] Development of a bacterial hyper-sensitive tester strain for specific detection of the genotoxicity of polycyclic aromatic hydrocarbons (2006)
  • Author(s): M.Yamada et al.
  • Journal Title: Genes and Environ. 28 Pages: 23-30
• [Journal Article] Specificity of replicative and SOS-inducible DNA polymerases in frameshift mutagenesis : Mutability of Salmonella typhimurium strains overexpressing SOS-inducible DNA polymerases to 30 chemical mutagens (2006)
  • Author(s): K.Matsui et al.
  • Journal Title: DNA Repair 5 Pages: 465-478
• [Journal Article] Visualization of the interaction between archaeal DNA polymerase and uracil-containing DNA by atomic force microscopy (2006)
  • Author(s): Y.Asami et al.
  • Journal Title: Genes to Cells 11 Pages: 3-11
• [Journal Article] MX, a by-product of water chlorination, lacks in vivo genotoxicity in gpt delta mice but inhibits gap junctional intercellular communication in rat WB cells (2006)
  • Author(s): A.Nishikawa et al.
  • Journal Title: Environ. Mol. Mutagen. 47 Pages: 48-55
• [Journal Article] Dynamic Bypass of a Major Cisplatin-DNA Adduct Revealed in Structural, Kinetic and in vivo Studies
  • Author(s): J.H.Y. Wong, J.A. Brown, Z. Suo, P. Blum, T. Nohmi, H. Ling
  • Journal Title: EMBO J. (in press)
• [Journal Article] DNA polymeraseds involved in the incorporation of oxidized nucleotides into DNA: the efficiency and template base preference
  • Author(s): A. Katafuchi, T. Nohmi
  • Journal Title: Mutat. Res. (in press)
• [Journal Article] Efficient and erroneous incorporation of oxidized DNA precursors by human DNA polymerase η
  • Author(s): M.Shimizu et al.
  • Journal Title: Biochemistry (印刷中)
• [Presentation] Nucleotide pool damage and Y-family DNA polymerases (2010)
  • Author(s): T.Nohmi
  • Organizer: Gordon Research Conferences, DNA damage, mutation & cancer
  • Place of Presentation: 米国、カリフォルニア州、ベンチュラ
  • Year and Date: 2010-03-21
• [Presentation] 遺伝子改変動物を用いる遺伝毒性試験の開発と評価 (2010)
  • Author(s): 能美健彦
  • Organizer: 第26回日本毒性病理学会学術集会
  • Place of Presentation: 金沢
  • Year and Date: 2010-02-03
• [Presentation] gpt delta ラットを用いた新しい短期包括試験法によるフランの毒性評価 (2010)
  • Author(s): 日比大介
  • Organizer: 第26回日本毒性病理学会学術集会
  • Place of Presentation: 金沢
  • Year and Date: 2010-02-03
• [Presentation] CYP誘導能を有する非遺伝毒性ラット肝発がん物質による酸化的DNA損傷ならびに in vivo 変異原性 (2010)
  • Author(s): 田崎雅子
  • Organizer: 第26回日本毒性病理学会学術集会
  • Place of Presentation: 金沢
  • Year and Date: 2010-02-03
• [Presentation] p53ノックアウト gpt delta マウス肝におけるMeIQxの変異原性に対するCCl_4誘発肝障害の修飾効果 (2010)
  • Author(s): 岡村俊也
  • Organizer: 第26回日本毒性病理学会学術集会
  • Place of Presentation: 金沢
  • Year and Date: 2010-02-03
• [Presentation] gpt delta transgenic rat におけるカプサイシンとシリマリンの化学予防効果 (2010)
  • Author(s): 豊田尚美
  • Organizer: 第26回日本毒性病理学会学術集会
  • Place of Presentation: 金沢
  • Year and Date: 2010-02-03
• [Presentation] F344系 gpt delta ラットを用いたDEN誘発肝の in vivo 変異原性ならびに前がん病変に対するトコトリエノールの修飾効果 (2010)
  • Author(s): 井上知紀
  • Organizer: 第26回日本毒性病理学会学術集会
  • Place of Presentation: 金沢
  • Year and Date: 2010-02-03
• [Presentation] ルシジン配糖体の gpt delta マウス腎臓における突然変異誘発性と遺伝子傷害性におよぼすスルフォトランスフェラーゼ阻害剤併用投与の影響 (2010)
  • Author(s): 石井雄二
  • Organizer: 第26回日本毒性病理学会学術集会
  • Place of Presentation: 金沢
  • Year and Date: 2010-02-03
• [Presentation] Nucleotide pool damage and Y-family DNA polymerases (2010)
  • Author(s): T. Nohmi
  • Organizer: Gorden Research Conferences, DNA damage, mutation & cancer, Ventura
  • Place of Presentation: CA, USA
• [Presentation] gpt delta トランスジェニックラットを用いた遺伝毒性試験の共同研究-1)肝発癌物質と非発癌物質の識別- (2009)
  • Author(s): 太田亮
  • Organizer: 日本環境変異原学会第38回大会
  • Place of Presentation: 静岡
  • Year and Date: 2009-11-26
• [Presentation] 能美健彦, gpt delta トランスジェニックラットを用いた遺伝毒性試験の共同研究-2)アリストロキア酸の遺伝毒性評価- (2009)
  • Author(s): 田〓修
  • Organizer: 日本環境変異原学会第38回大会
  • Place of Presentation: 静岡
  • Year and Date: 2009-11-26
• [Presentation] gpt delta トランスジェニックラットを用いた遺伝毒性試験の共同研究-3)亜硫化ニッケルの気管内投与による遺伝毒性評価- (2009)
  • Author(s): 野口忠
  • Organizer: 日本環境変異原学会第38回大会
  • Place of Presentation: 静岡
  • Year and Date: 2009-11-26
• [Presentation] ハイ・スループット微生物遺伝毒性試験法の検討5 (2009)
  • Author(s): 須井哉
  • Organizer: 日本環境変異原学会第38回大会
  • Place of Presentation: 静岡
  • Year and Date: 2009-11-26
• [Presentation] ライフステージ(週齢)を考慮したアクリルアミドの多臓器遺伝毒性評価 (2009)
  • Author(s): 小山直己
  • Organizer: 日本環境変異原学会第38回大会
  • Place of Presentation: 静岡
  • Year and Date: 2009-11-26
• [Presentation] ナノ粒子により誘発される in vivo 遺伝毒性 (2009)
  • Author(s): 松本陽子
  • Organizer: 日本環境変異原学会第38回大会
  • Place of Presentation: 静岡
  • Year and Date: 2009-11-26
• [Presentation] DNA-タンパク質クロスリンク損傷の修復および回避機構に関する遺伝学的研究 (2009)
  • Author(s): 井出博
  • Organizer: 日本環境変異原学会第38回大会
  • Place of Presentation: 静岡
  • Year and Date: 2009-11-26
• [Presentation] ヒトDNAポリメラーゼηを発現する大腸菌umuDC欠損株における紫外線による誘発突然変異の検出 (2009)
  • Author(s): ピーター グルーズ
  • Organizer: 日本環境変異原学会第38回大会
  • Place of Presentation: 静岡
  • Year and Date: 2009-11-26
• [Presentation] 次世代DNAシークエンサーを用いた gpt delta トランスジェニックマウスのトランスジーン挿入部位の解析 (2009)
  • Author(s): 増村健一
  • Organizer: 日本環境変異原学会第38回大会
  • Place of Presentation: 静岡
  • Year and Date: 2009-11-26
• [Presentation] ヒトDNAポリメラーゼh及びkの8-oxo-dGTP取り込み活性に関する解析 (2009)
  • Author(s): 片渕淳
  • Organizer: 日本放射線影響学会第52回大会
  • Place of Presentation: 広島
  • Year and Date: 2009-11-13
• [Presentation] Establishment of of humance cell lines lacking the catalytic activity of DNA polymerase kappa involved in translesion DNA synthesis (2009)
  • Author(s): 新見直子
  • Organizer: The 40^<th> International Symposium of the Princess Takamatsu Cancer Research Foundation
  • Place of Presentation: 東京
  • Year and Date: 2009-11-12
• [Presentation] in vivo mutagenesis induced by air pollutants in the testis of gpt delta transgenic mice (2009)
  • Author(s): Y.Aoki
  • Organizer: 疾患生命工学センター第4回シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2009-10-26
• [Presentation] ナノ粒子により誘発される遺伝毒性:in vivo 小核, in vivo コメットおよび変異原性の解析 (2009)
  • Author(s): 戸塚ゆ加里
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-01
• [Presentation] 食品中のCYP1A2誘導材によるIQの in vivo 変異原性への複合影響 (2009)
  • Author(s): 鈴木裕太
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-01
• [Presentation] Tocotrienol 投与ラット肝における in vivo 変異原性ならびにプロモーション作用の欠如 (2009)
  • Author(s): 井上知紀
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-01
• [Presentation] F344 gpt delta rat を用いた2, 4-ジアミノトルエンによる発がん標的臓器における点突然変異の検出 (2009)
  • Author(s): 豊田尚美
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-01
• [Presentation] 改変 Ames 試験菌株YG3206を用いた内在性の変異原物質の検索に関する研究 (2009)
  • Author(s): 山田雅巳
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-01
• [Presentation] フルメキン同時投与によるMeIQxの in vivo 変異原性に及ぼす促進効果 (2009)
  • Author(s): 梅村隆志
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-01
• [Presentation] Development of gpt delta transgenic mice and rats for genotoxicity assays (2009)
  • Author(s): T.Nohmi
  • Organizer: The 5^<th> International Congress of Asian Society of Toxicology
  • Place of Presentation: 台北、台湾
  • Year and Date: 2009-09-13
• [Presentation] Possible mechanisms underlying practical thresholds for genotoxic carcinogens (2009)
  • Author(s): T.Nohmi
  • Organizer: 10^<th> International Conference on Environmental Mutagens
  • Place of Presentation: フィレンツェ、イタリア
  • Year and Date: 2009-08-22
• [Presentation] Combined genotoxic effects of a methylating agent and radiation on human cells (2009)
  • Author(s): A.Yamamoto
  • Organizer: 10^<th> International Conference on Environmental Mutagens
  • Place of Presentation: フィレンツェ、イタリア
  • Year and Date: 2009-08-22
• [Presentation] Genotoxicity of nanoparticles in in vitro micronuclei, in vivo comet and mutation assay systems (2009)
  • Author(s): 戸塚ゆ加里
  • Organizer: 10^<th> International Conference on Environmental Mutagens
  • Place of Presentation: フィレンツェ、イタリア
  • Year and Date: 2009-08-22
• [Presentation] Child-addult differences in evaluation of in vivo genotoxicity of acrylamide (2009)
  • Author(s): 小山直己
  • Organizer: 10^<th> International Conference on Environmental Mutagens
  • Place of Presentation: フィレンツェ、イタリア
  • Year and Date: 2009-08-22
• [Presentation] in vivo mutagenicity of structural isomers 2, 4-DAT and 2, 6-DAT in the target organ for carcinogenicity in F344 gpt delta transgenic rat (2009)
  • Author(s): 増村健一
  • Organizer: 10^<th> International Conference on Environmental Mutagens
  • Place of Presentation: フィレンツェ、イタリア
  • Year and Date: 2009-08-22
• [Presentation] Erroneous incorporation of oxidized nucleotides by Y-family DNA polymerases (2009)
  • Author(s): 片渕淳
  • Organizer: 10^<th> International Conference on Environmental Mutagens
  • Place of Presentation: フィレンツェ、イタリア
  • Year and Date: 2009-08-21
• [Presentation] Current status of F344 gpt delta rats for in vivo mutagenesis (2009)
  • Author(s): T.Nohmi
  • Organizer: 5^<th> International Workshop on genotoxicity testing
  • Place of Presentation: バーゼル、スイス
  • Year and Date: 2009-08-19
• [Presentation] Genotoxic versus non-genotoxic mechanisms : feed-back from Genotoxic and Carcinogenic Thresholds in Tokyo (2009)
  • Author(s): T.Nohmi
  • Organizer: 5^<th> International Workshop on genotoxicity testing
  • Place of Presentation: バーゼル、スイス
  • Year and Date: 2009-08-19
• [Presentation] gpt delta transgenic rats and mice for genotoxicity assays : identification of genetic alterations at target organs of chemical carinogens (2009)
  • Author(s): T.Nohmi
  • Organizer: United Kingdom Environmental Mutagen Society 32^<nd> Annual Meeting
  • Place of Presentation: リーズ、英国
  • Year and Date: 2009-07-13
• [Presentation] A crucial role for the steric gate amino acid tyrosine 112 in efficient mismatched-primer (2009)
  • Author(s): T. Nohmi
  • Organizer: extension by human DNA polymerase k, ASM Conferences, DNA Repair and Mutagenesis
  • Place of Presentation: Whistler, Canada
  • Year and Date: 2009-06-01
• [Presentation] A crucial role for the steric gate amino acid tyrosine 112 in efficient mislnatched-primer extension by human DNA polymerase κ (2009)
  • Author(s): 新見直子
  • Organizer: ASM Conferences, DNA Repair and Mutagenesis
  • Place of Presentation: ウィスラー、カナダ
  • Year and Date: 2009-05-31
• [Presentation] ピペロニルブトキサイドのp53欠損 gpt delta マウスを用いた in vivo 変異原性 (2009)
  • Author(s): 田崎雅子
  • Organizer: 第25回 毒性病理学会総会および学術集会
  • Place of Presentation: 浜松、静岡
  • Year and Date: 2009-01-27
• [Presentation] F344 gpt delta ラット肝におけるDEN誘発 in vivo 変異原性ならびに前がん病変に対するトコトリエノールの修飾効果 (2009)
  • Author(s): 井上知紀
  • Organizer: 第25回 毒性病理学会総会および学術集会
  • Place of Presentation: 浜松、静岡
  • Year and Date: 2009-01-27
• [Presentation] gpt delta transgenic rat を用いた構造異性体2,4-DAT、2,6-DATの遺伝毒性解析 (2009)
  • Author(s): 豊田尚美
  • Organizer: 第25回 毒性病理学会総会および学術集会
  • Place of Presentation: 浜松、静岡
  • Year and Date: 2009-01-27
• [Presentation] MeIQx 誘発 gpt delta マウス大腸の in vivo 変異原性ならびに発がん性に対する慢性炎症の影響について (2009)
  • Author(s): 岡村俊也
  • Organizer: 第25回 毒性病理学会総会および学術集会
  • Place of Presentation: 浜松、静岡
  • Year and Date: 2009-01-27
• [Presentation] アカネ色素ラット腎発がん過程に関与する色素成分の検索 (2009)
  • Author(s): 石井雄二
  • Organizer: 第25回 毒性病理学会総会および学術集会
  • Place of Presentation: 浜松、静岡
  • Year and Date: 2009-01-27
• [Presentation] ヒト細胞におけるDNAポリメラーゼκの機能解析 (2009)
  • Author(s): 新見直子, 飯泉晋, 足立典隆, 小山秀樹, 能美健彦
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
• [Presentation] Establishment of of human cell lines lacking the catalytic activity of DNA polymerase kappa involved in translesion DNA synthesis (2009)
  • Author(s): N. Niimi, P. Gruz, S. Iiizumi, N. Adachi, H. Koyama, T. Nohmi
  • Organizer: The 40th International Symposium of the Princess Takamatsu Cancer Research Foundation
  • Place of Presentation: Tokyo
• [Presentation] Erroneous incorporation of oxidized nucleotides by Y-family DNA polymerases (2009)
  • Author(s): A. Katafuchi, A. Sassa, N. Niimi, P. Gruz, H. Fujimoto, C. Masutani, F. Hanaoka, T. Ohta, T. Nohmi
  • Organizer: 10th International Conference on Environmental Mutagens in Firenze
  • Place of Presentation: Italy
• [Presentation] Possible mechanisms underlying practical thresholds for genotoxic carcinogens (2009)
  • Author(s): T. Nohmi
  • Organizer: 10th International Conference on Environmental Mutagens in Firenze
  • Place of Presentation: Italy
• [Presentation] Genotoxic versus non-genotoxic mechanisms: feed-back from Genotoxic and Carcinogenic Thresholds in Tokyo (2009)
  • Author(s): T. Nohmi
  • Organizer: 5th International Workshop on genotoxicity testing, Basel
  • Place of Presentation: Switzerland
• [Presentation] A crucial role for the steric gate amino acid tyrosine 112 in efficient mismatched-primer extension by human DNA polymeraseκ (2009)
  • Author(s): N. Niimi, A. Sassa, A. Katafuchi, P. Gruz, H. Fujimoto, R. -R. Bonala, F. Johnson, T. Ohta, T. Nohmi
  • Organizer: ASM Conferences, DNA Repair and Mutagenesis in Whistler
  • Place of Presentation: BC, Canada
• [Presentation] Control of multiple DNA polymerases dealing with lesions induced by environmental mutagens (2009)
  • Author(s): T. Nohmi, K. Kokubo, M. Yamada, P. Gruz
  • Organizer: 36th Annual Meeting of the European Environmental Mutagen Society in Prague
  • Place of Presentation: Czech
• [Presentation] ヒトDNAポリメラーゼκにおける cleft アミノ酸変異の損傷DNAに対する親和性への影響 (2008)
  • Author(s): 佐々彰
  • Organizer: 第31回日本分子生物学会年会,第81回日本生化学会大会
  • Place of Presentation: 神戸、兵庫
  • Year and Date: 2008-12-12
• [Presentation] Transgenic in vivo genotoxicity assays : basic features and the possible applications (2008)
  • Author(s): T. Nohmi
  • Organizer: 14^<th> Alexander Hollaender Course on Genetic Toxicology : Genomic and Proteomic Approaches & Special Workshop on Arsenic Exposure Assessment in Kolkata
  • Place of Presentation: Kolkata, India
  • Year and Date: 2008-12-11
• [Presentation] 細胞におけるDNAポリメラーゼκの機能解析 (2008)
  • Author(s): 新見直子
  • Organizer: 日本環境変異原学会第37回大会
  • Place of Presentation: 宜野湾、沖縄
  • Year and Date: 2008-12-04
• [Presentation] ライフステージを考慮したアクリルアミドの多臓器遺伝毒性評価 (2008)
  • Author(s): 小山直己
  • Organizer: 日本環境変異原学会第37回大会
  • Place of Presentation: 宜野湾、沖縄
  • Year and Date: 2008-12-04
• [Presentation] 塩素化多環芳香族炭化水素類の変異原性評価 (2008)
  • Author(s): 大浦健
  • Organizer: 日本環境変異原学会第37回大会
  • Place of Presentation: 宜野湾、沖縄
  • Year and Date: 2008-12-04
• [Presentation] 改変 Ames 試験菌株を用いた内在性の変異原物質の検索とその変異誘発機構に関する研究 (2008)
  • Author(s): 山田雅巳
  • Organizer: 日本環境変異原学会第37回大会
  • Place of Presentation: 宜野湾、沖縄
  • Year and Date: 2008-12-04
• [Presentation] gpt delta ラットを用いたアカネ色素成分による in vivo 突然変異誘発性の検討 (2008)
  • Author(s): 石井雄二
  • Organizer: 日本環境変異原学会第37回大会
  • Place of Presentation: 宜野湾、沖縄
  • Year and Date: 2008-12-04
• [Presentation] ナノ粒子により誘発される遺伝毒性の in vivo アッセイによる解析 (2008)
  • Author(s): 戸塚ゆ加里
  • Organizer: 日本環境変異原学会第37回大会
  • Place of Presentation: 宜野湾、沖縄
  • Year and Date: 2008-12-04
• [Presentation] ハイ・スループット微生物遺伝毒性試験法の検討4 (2008)
  • Author(s): 須井哉
  • Organizer: 日本環境変異原学会第37回大会
  • Place of Presentation: 宜野湾、沖縄
  • Year and Date: 2008-12-04
• [Presentation] gpt delta transgenic rat を用いた発がん標的臓器における構造異性体2,4-DAT、2,6-DATの遺伝毒性解析 (2008)
  • Author(s): 豊田尚美
  • Organizer: 日本環境変異原学会第37回大会
  • Place of Presentation: 宜野湾、沖縄
  • Year and Date: 2008-12-04
• [Presentation] gpt-delta マウス胸腺での、ENUとX線の複合曝露におけるX線の後照射による影響 (2008)
  • Author(s): 山内一己
  • Organizer: 日本環境変異原学会第37回大会
  • Place of Presentation: 宜野湾、沖縄
  • Year and Date: 2008-12-04
• [Presentation] gpt delta トランスジェニックマウスおよびラットにおける自然突然変異の解析 (2008)
  • Author(s): 増村健一
  • Organizer: 日本環境変異原学会第37回大会
  • Place of Presentation: 宜野湾、沖縄
  • Year and Date: 2008-12-04
• [Presentation] in vivo 突然変異を解析するための gpt delta トランスジェニックマウスおよびラット (2008)
  • Author(s): 能美健彦
  • Organizer: 日本環境変異原学会第37回大会
  • Place of Presentation: 宜野湾、沖縄
  • Year and Date: 2008-12-04
• [Presentation] Combined genotoxic effects of a methylating agent and radiation on human cells (2008)
  • Author(s): T. Nohmi
  • Organizer: New Nuclear Research Symposium, Biological Responses to Low Dose Radiation
  • Place of Presentation: 北九州、福岡
  • Year and Date: 2008-11-18
• [Presentation] The steric gate tyrosine 112 is crucial to the efficient mismatched-primer extension by human DNA polymerase κ (2008)
  • Author(s): N. Niimi
  • Organizer: 3R (Replication, Recombination, Repair)
  • Place of Presentation: 掛川、静岡
  • Year and Date: 2008-10-28
• [Presentation] F344 gpt delta トランスジェニックラットにおける構造異性体2,4-DATおよび2,6-DATの変異原性の検討 (2008)
  • Author(s): 豊田尚美
  • Organizer: 第67回 日本癌学会学術総会
  • Place of Presentation: 名古屋、愛知
  • Year and Date: 2008-10-28
• [Presentation] gpt delta マウスを用いた四塩化炭素誘発肝障害モデルにおけるMeIQxの in vivo 突然変異解析 (2008)
  • Author(s): 岡村俊也
  • Organizer: 第67回 日本癌学会学術総会
  • Place of Presentation: 名古屋、愛知
  • Year and Date: 2008-10-28
• [Presentation] p53はUVB照射および非照射マウスの表皮で誘発される欠失変異を抑制する (2008)
  • Author(s): 増村健一
  • Organizer: 第67回 日本癌学会学術総会
  • Place of Presentation: 名古屋、愛知
  • Year and Date: 2008-10-28
• [Presentation] Recent Topics of Mutation Research with gpt delta Mice and Rats (2008)
  • Author(s): T. Nohmi
  • Organizer: 39^<th> Annual Meeting of Environmental Mutagen Society
  • Place of Presentation: Puerto Rico
  • Year and Date: 2008-10-22
• [Presentation] gpt delta transgenic mice for in vivo genotoxicity assays : application for analysis of combined effects of radiation and chemicals (2008)
  • Author(s): T. Nohmi
  • Organizer: The 7th Japan-France Workshop on Radiation Biology
  • Place of Presentation: 稲毛、千葉
  • Year and Date: 2008-10-15
• [Presentation] Genotoxicity of nanoparticles in in vivo mutation assay systems (2008)
  • Author(s): Y. Totsuka
  • Organizer: 38^<th> European Environmental Mutagen Society
  • Place of Presentation: Covtat, Croatia
  • Year and Date: 2008-09-20
• [Presentation] Development of a tester strain sensitive to chemicals inducing oxidative pyrimidines (2008)
  • Author(s): M. Yamada
  • Organizer: 38^<th> European Environmental Mutagen Society
  • Place of Presentation: Covtat, Croatia
  • Year and Date: 2008-09-20
• [Presentation] Possible Mechanisms of Practical Genotoxic Thresholds (2008)
  • Author(s): T. Nohmi
  • Organizer: International Symposium on Genotoxic and Carcinogenic Thresholds
  • Place of Presentation: 東京
  • Year and Date: 2008-07-22
• [Presentation] Oxidative DNA damage and its genotoxic consequence in vivo (2008)
  • Author(s): T.Nohmi
  • Organizer: Joint-meeting of the Genes, Environment and Diseases Panels, the US-Japan Cooperative Medical Science Program
  • Place of Presentation: San Francisco, U.S.A.
  • Year and Date: 2008-03-27
• [Presentation] Validity of gpt delta transgenic rodent genotoxicity assays (2008)
  • Author(s): T.Nohmi
  • Organizer: 47^<th>Annual Meeting of Society of Toxicology
  • Place of Presentation: Seattle,U.S.A.
  • Year and Date: 2008-03-19
• [Presentation] ヌクレオチドプールの酸化を介したDNA損傷と突然変異 (2008)
  • Author(s): 能美 健彦
  • Organizer: 情報計算化学生物学会
  • Place of Presentation: 東京
  • Year and Date: 2008-02-04
• [Presentation] Development of in vivo genotoxicity assays with transgenic mice and rats,Intrnational Symposium on the Predictive (2008)
  • Author(s): T.Nohmi
  • Organizer: Preventive and Mechanistic Mutagenesis & XXXIII EMSI Annual Meeting
  • Place of Presentation: Aligarh,India
  • Year and Date: 2008-01-02
• [Presentation] Possible Mechanisms of Practical Genotoxic Thresholds (2008)
  • Author(s): T. Nohmi
  • Organizer: International Symposium on Genotoxic and Carcinogenic Thresholds
  • Place of Presentation: Tokyo
• [Presentation] 大腸菌DNAポリメラーゼIIIによる酸化的損傷ヌクレオチドの取り込み (2007)
  • Author(s): 清水 雅富, P.Gruz, 藤井 慎吾, 紙谷 浩之, 徐岩, 碓井 之雄, 杉山 弘, 原島 秀吉, R. P.Fuchs, 能美 健彦
  • Organizer: 第30回日本分子生物学会, 第80回日本生化学会合同大会
  • Place of Presentation: 東京
  • Year and Date: 2007-12-13
• [Presentation] ヒトDNAポリメラーゼκの損傷DNAに対する親和性と伸長反応の解析 (2007)
  • Author(s): 新見 直子, 佐々 彰, 片渕 淳, ピーター グルーズ, 能美 健彦
  • Organizer: 第30回日本分子生物学会, 第80回日本生化学会合同大会
  • Place of Presentation: 東京
  • Year and Date: 2007-12-13
• [Presentation] Chemopreventive effects of nobiletin,a citrus constituent,against the genotoxicity of NNK,a tobacco-specific nitrosamine,in the lung of gpt delta transgenic mice (2007)
  • Author(s): M.Ikeda, K.Masumura, K.Matsui, H.Kohno, K.Sakuma, T.Tanaka, T.Kamataki, and T.Nohmi
  • Organizer: The 9^<th>International Conference on Mechanisms of Antimutagenesis and Anticarcinogenesis(ICMAA-2007)
  • Place of Presentation: Cheju,Korea
  • Year and Date: 2007-12-04
• [Presentation] in vivo mutations by 3,6-dinitrobenzo[e]pyrene instilled into the lung of gpt delta transgenic mice (2007)
  • Author(s): M.Matsumoto, K.Amanuma, A. H.Hashimoto, Y.Sakashita, R.Yanagisawa, H.Takano, K.Masumura, T.Nohmi, K.Wakabyashi, T.Watanabe, and Y.Aoki
  • Organizer: 1^<st>Asian Conference on Environmental Mutagens(1^<st>ACEM)/36^<th>Annual Meeting of the Japanese Environmental Mutagen Society(36^<th>JEMS)
  • Place of Presentation: 北九州
  • Year and Date: 2007-11-29
• [Presentation] Antigenotoxic effects of p53 on UVB-induced and spontaneous dele tions in the murine epidermis (2007)
  • Author(s): Y.Sakamoto, M.Ikeda, K.Masumura, Y.Asami, T.Tsukamoto, H.Ikehata, Y.Kuroiwa, T.Umemura, A.Nishikawa, M.Tatematsu, T.Ono and T.Nohmi
  • Organizer: 1^<st>Asian Conference on Environmental Mutagens(1^<st>ACEM)/36^<th>Annual Meeting of the Japanese Environmental Mutagen Society(36^<th>JEMS)
  • Place of Presentation: 北九州
  • Year and Date: 2007-11-29
• [Presentation] Generation and characterization of human cells knocked-in and knocked-out of DNA polymerase kappa (2007)
  • Author(s): N.Niimi,and T.Nohmi
  • Organizer: 1^<st>Asian Conference on Environmental Mutagens(1^<st>ACEM)/36^<th>Annual Meeting of the Japanese Environmental Mutagen Society (36^<th>JEMS)
  • Place of Presentation: 北九州
  • Year and Date: 2007-11-29
• [Presentation] Translesion synthesis past 2'-deoxyinosine,a major nitric oxide-induced DNA adduct,by human DNA polymerase eta and kappa (2007)
  • Author(s): M.Yasui, E.Suenaga, N.Koyama, C.Masutani, F.Hanaoka, P.Gruz, S.Shibutani, T.Nohmi, M.Hayashi, and M.Honma
  • Organizer: 1^<st>Asian Conference on Environmental Mutagens(1^<st>ACEM)/36^<th>Annual Meeting of the Japanese Environmental Mutagen Society(36^<th>JEMS)
  • Place of Presentation: 北九州
  • Year and Date: 2007-11-29
• [Presentation] Effects of human Y-family DNA polymerases expressed in the enterobacterial mutagenicity tester strains (2007)
  • Author(s): P.Gruz, K.Matsui, and T.Nohmi
  • Organizer: 1^<st>Asian Conference on Environmental Mutagens(1^<st>ACEM)/36^<th> Annual Meeting of the Japanese Environmental Mutagen Society(36^<th>JEMS)
  • Place of Presentation: 北九州
  • Year and Date: 2007-11-29
• [Presentation] Novel Salmonella strains highly sensitive to mutagens that cause oxidized pyrimidines in DNA (2007)
  • Author(s): M.Yamada, K.Matui,and T.Nohmi
  • Organizer: 1^<st>Asian Conference on Environmental Mutagens(1^<st>ACEM)/36^<th>Annual Meeting of the Japanese Environmental Mutagen Society(36^<th>JEMS)
  • Place of Presentation: 北九州
  • Year and Date: 2007-11-29
• [Presentation] Chemopreventive effects of nobiletin against genotoxicity induced by NNK in the lung of gpt delta transgenic mice (2007)
  • Author(s): K.Masumura, M.Ikeda, K.Matsui, T.Tanaka, and T.Nohmi
  • Organizer: 1^<st>Asian Conference on Environmental Mutagens(1^<st>ACEM)/36^<th>Annual Meeting of the Japanese Environmental Mutagen Society(36^<th>JEMS)
  • Place of Presentation: 北九州
  • Year and Date: 2007-11-29
• [Presentation] gpt-deltaマウスを用いた複合曝露胸腺細胞における欠失変異の解析 (2007)
  • Author(s): 山内 一己, 柿沼 志津子, 須藤 聡美, 太田 有紀, 鬼頭 誠司, 増村 健一, 能美 健彦, 西村 まゆみ, 島田 義也
  • Organizer: 日本放射線影響学会第50回大会
  • Place of Presentation: 千葉
  • Year and Date: 2007-11-14
• [Presentation] Suppression of radiation-induced large deletions by combined treatments with a tobacco-specific nitrosamine in the lung of gpt delta transgenic mice,New Nuclear Research Symposium (2007)
  • Author(s): M.Ikeda, K.Masumura, Y.Sakamoto, B.Wang, M.Nenoi, K.Sakuma, I.Hayata, and T.Nohmi
  • Organizer: New Nuclear Research Symposium, Biological Responses to Low Dose Radiation
  • Place of Presentation: 千葉
  • Year and Date: 2007-11-14
• [Presentation] Dose dependency of combined effects of ionizing radiation and other agents on cancer induction (2007)
  • Author(s): Y.Shimada, M.Nishimura, S.Kakinuma, K.Yamauchi, T.Imaoka, Y.Shang, T.Nohmi, I.Kawaguchi, M.Doi
  • Organizer: New Nuclear Research Symposium, Biological Responses to Low Dose Radiation
  • Place of Presentation: 東京
  • Year and Date: 2007-11-13
• [Presentation] Development of bacteria genotoxicity assays:past,present and future perspective (2007)
  • Author(s): T.Nohmi
  • Organizer: VIII Congresso Brasileiro de Mutagenese Carcinogenese e Teratogenese Ambiental(SBMCTA2007)
  • Place of Presentation: Angra dos Reis,Brazil
  • Year and Date: 2007-10-31
• [Presentation] The role of Y-family DNA polymerase in oxidative mutagenesis (2007)
  • Author(s): T.Nohmi
  • Organizer: 38^<th>Annual Meeting of Environmental Mutagen Society
  • Place of Presentation: Atlanta,U.S.A.
  • Year and Date: 2007-10-22
• [Presentation] Formation of RNA adduct with a novel endogenous mutagen and carcinogen,aminophenylnorharman (2007)
  • Author(s): Y.Totsuka, R.Nishigaki, T.Takamura-Enya, T.Nohmi, T.Sugimura, and K.Wakabayashi
  • Organizer: 38^<th>Annual Meeting of Environmental Mutagen Society
  • Place of Presentation: Atlanta,U.S.A.
  • Year and Date: 2007-10-22
• [Presentation] Existence of thresholds for carcinogenicity and in vivo mutagenicity of 1,4-dioxane in liver of rats (2007)
  • Author(s): 大西 真理子, 大森 雅子, 魏民, 増村 健一, 能美 健彦, 鰐淵 英機, 福島 昭治
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2007-10-03
• [Presentation] DNA repair as a constituent of thresholds of genotoxicity (2007)
  • Author(s): T.Nohmi
  • Organizer: 37^<th>European Environmental Mutagen Society
  • Place of Presentation: Basel,Switzerland
  • Year and Date: 2007-09-11
• [Presentation] Validity of in vivo genotoxicology (2007)
  • Author(s): T.Nohmi
  • Organizer: 6^<th>World Congress on Alternatives & Animal Use in the Life Sciences
  • Place of Presentation: 東京
  • Year and Date: 2007-08-23
• [Presentation] アスコルビン酸と亜硝酸ナトリウム複合影響による変異原性ならびにラット前胃発がんイニシェーション作用の検索 (2007)
  • Author(s): 黒岩 有一、山田 雅巳、松井 恵子、増村 健一、岡村 俊也、田崎 雅子、梅村 隆志、能美 健彦、西川 秋佳、広瀬 雅雄
  • Organizer: 第34回日本トキシコロジー学会学術年会
  • Place of Presentation: 東京
  • Year and Date: 2007-06-27
• [Presentation] Asbestos and other environmental toxic chemicals (2007)
  • Author(s): T.Nohmi
  • Organizer: The 5^<th>International Conference on Environmental Mutagens in Human Populations in Antalya
  • Place of Presentation: Antalya,Turkey
  • Year and Date: 2007-05-23
• [Presentation] Roles of Y-family DNA polymerases in mutagenesis via the misincorporation of oxidized dNTPs (2007)
  • Author(s): T.Nohmi
  • Organizer: The 3^<rd>Japan US DNA repair meeting
  • Place of Presentation: 仙台
  • Year and Date: 2007-05-09
• [Presentation] The role of Y-family DNA polymerase in oxidative mutagenesis (2007)
  • Author(s): T. Nohmi
  • Organizer: 38th Annual Meeting of Environmental Mutagen Society in Atlanta
  • Place of Presentation: USA
• [Presentation] DNA repair as a constituent of thresholds of genotoxicity (2007)
  • Author(s): T. Nohmi
  • Organizer: 37th European Environmental Mutagen Society
  • Place of Presentation: Basel, Switzerland
• [Presentation] Roles of Y-family DNA polymerases in mutagenesis via the misincorporation of oxidized dNTPs (2007)
  • Author(s): T. Nohmi
  • Organizer: The 3rd Japan US DNA repair meeting in Sendai
  • Place of Presentation: Japan
• [Book] DNA repair and DNA damage tolerance in archaeal bacteria: extreme environments and genome integrity, in Archaea: new models for prokaryotic biology (2008)
  • Author(s): T. Nohmi, M. Yamada, P. Gruz
  • Publisher: Horizon Scientific Press.
• [Book] Archaea:new models for prokaryotic biology (2008)
  • Author(s): T.Nohmi
  • Publisher: Horizon Scientific Press
• [Remarks] ホームページ等
  • URL: http://dgm2alpha.nihs.go.jp/
• [Remarks]
  • URL: http://dgm2alpha.nihs.go.jp/
• [Remarks]
  • URL: http://dgm2alpha.nihs.go.jp/-nohmi/T.N/T.N%20updated.htm
• [Remarks]
  • URL: http://dgm2alpha.nihs.go.jp/
• [Patent(Industrial Property Rights)] 突然変異検出用トランスジェニックラットとその作製方法およびそれを用いた突然変異試験法 (2006)
  • Inventor(s): 能美健彦、増村健一、神藤康弘、林宏行
  • Industrial Property Rights Holder: 国立医薬品食品衛生研究所長
  • Filing Date: 2006-05-12
  • Acquisition Date: 2006-05-12
• [Patent(Industrial Property Rights)] 突然変異検出用トランスジェニックラットとその作製方法およびそれを用いた突然変異試験法 (2006)
  • Inventor(s): 能美健彦, 増村健一, 神藤康弘, 林 宏行
  • Industrial Property Rights Holder: 国立医薬品食品衛生研究所長
  • Acquisition Date: 2006-05-12