| Project/Area Number |
18201041
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
ISHIKAWA Toshihisa Tokyo Institute of Technology, オミックス基盤研究領域, 客員主管研究員 (60193281)
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| Co-Investigator(Kenkyū-buntansha) |
櫻井 実 東京工業大学, バイオ研究基盤支援総合センター, 教授 (50162342)
土井 隆行 東京工業大学, 大学院・理工学研究科, 准教授 (90212076)
中川 大 東京工業大学, 大学院・生命理工学研究科, 助教 (40397039)
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| Co-Investigator(Renkei-kenkyūsha) |
SAKURAI Minoru 東京工業大学, バイオ研究基盤支援総合センター, 教授 (50162342)
DOI Takayuki 東北大学, 大学院・薬学研究科, 教授 (90212076)
NAKAGAWA Hiroshi 東京工業大学, 生命理工学研究科, 助手 (40397039)
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| Project Period (FY) |
2006 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥49,140,000 (Direct Cost: ¥37,800,000、Indirect Cost: ¥11,340,000)
Fiscal Year 2009: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Fiscal Year 2008: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Fiscal Year 2007: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2006: ¥20,280,000 (Direct Cost: ¥15,600,000、Indirect Cost: ¥4,680,000)
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| Keywords | 癌 / 脳・神経 / 生理活性 / 創薬 / 分子プローブ |
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| Research Abstract |
The efficacy of cancer chemotherapy in brain tumors is substantially limited by cellular mechanisms where the blood-bran-barrier limits drug penetration into the brain. ATP-binding cassette (ABC) transporters, e.g., ABCB1 and ABCG2, play pivotal roles. In this research project, we have developed high-speed screening and quantitative structure-activity-relationship (QSAR) analysis methods to design anticancer drug molecules that efficiently target brain tumors.
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