| Project/Area Number |
18201042
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | Osaka University |
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Principal Investigator |
KOBAYASHI Motomasa Osaka University, 大学院・薬学研究科, 教授 (40116033)
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| Co-Investigator(Kenkyū-buntansha) |
AOKI Shunji 大阪大学, 大学院・薬学研究科, 講師 (60252699)
荒井 雅吉 大阪大学, 薬学研究科, 助教 (80311231)
古徳 直之 大阪大学, 薬学研究科, 助教 (20362618)
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| Co-Investigator(Renkei-kenkyūsha) |
KOTOKU Naoyuki 大阪大学, 大学院・薬学研究科, 助教 (20362618)
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| Research Collaborator |
ARAI Masayoshi 大阪大学, 大学院・薬学研究科, 助教 (80311231)
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| Project Period (FY) |
2006 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥51,870,000 (Direct Cost: ¥39,900,000、Indirect Cost: ¥11,970,000)
Fiscal Year 2009: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
Fiscal Year 2008: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
Fiscal Year 2007: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
Fiscal Year 2006: ¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
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| Keywords | 海洋生物 / 分子標的 / 海綿 / 血管新生 / 活性試験 / 抗がん剤 / 血管新来生阻害 / 低酸素環境 / 血管新生阻害 |
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| Research Abstract |
To explore new lead compounds for molecular target chemotherapy of cancer, we have established screening systems based on the novel biological and molecular biological findings of cancer. Then, we have searched bioactive natural compounds from the extracts libraries of marine organisms, marine-derived microbe and medicinal plants by constructed bioassay-guided separation. As a result, we have found seven bioactive compounds totally and examined total synthesis, structure-activity relationship, and synthesis of model compounds. Moreover, the mechanistic-studies were performed by the chemical biology method.
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