Development of Separation Concepts Applicable to Various Material Dimensions

• Project/Area Number: 18205011
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Analytical chemistry
• Research Institution: Tokyo Institute of Technology
• Principal Investigator: OKADA Tetsuo Tokyo Institute of Technology, 大学院・理工学研究科, 教授 (20183030)
• Co-Investigator(Kenkyū-buntansha): HARADA Makoto 東京工業大学, 大学院・理工学研究科, 助教 (60313326)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥40,170,000 (Direct Cost: ¥30,900,000、Indirect Cost: ¥9,270,000); Fiscal Year 2008: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2007: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000); Fiscal Year 2006: ¥26,260,000 (Direct Cost: ¥20,200,000、Indirect Cost: ¥6,060,000)
• Keywords: 粒子分離 / 高速分離 / 氷 / 分子集合体 / 粒子 / 電場 / 超音波 / 反応速度 / 水溶性高分子 / 水溶性ポリマー

Research Abstract

分離対象の物質の大きさの次元と寿命に相当する時間次元の観点から以下の検討を行った。具体的な手法としては、ワイドボアハイドロダイナミッククロマトグラフィー、電場スイッチング、超音波/重力複合場による粒子分離と高速分離、イオン移動ボルタンメトリー、X 線吸収微細構造による分離場における物質構造の解明、低温分離が可能で新規な方法論としての潜在性をもつアイスクロマトグラフィーなどについて検討し、種々の新分離概念を考案、構築した。

Research Products

• [Journal Article] Multivariate Analysis of DSC-XRD Simultaneous Measurement Data : a Study of Multistage Crystalline Structure Changes in a Linear Poly(ethylene imine) Thin Film (2009)
  • Author(s): H.Kakuda, T.Okada, M.Otsuka, Y.Katsumoto, T.Hasegawa
  • Journal Title: Anal.Bioanal.Chem. 393 Pages: 367-376
  • Peer Reviewed
• [Journal Article] Adsorption-partition Switching of Retention Mechanism in Ice Chromatography with NaCl-doped Water-ice (2009)
  • Author(s): Y.Tasaki, T.Okada
  • Journal Title: Anal.Sci. 25 Pages: 177-181
  • NAID: 10025209985
  • Peer Reviewed
• [Journal Article] Electrophoretic Levitation of Particles by Field Switching (2009)
  • Author(s): M.Yamada, M.Harada, T.Okada
  • Journal Title: Anal.Sci. 25 Pages: 279-284
  • Peer Reviewed
• [Journal Article] Wide-bore Hydrodynamic Chromatography in Sub-second Range (2009)
  • Author(s): R.Umehara, M.Harada, T.Okada
  • Journal Title: J.Sep.Sci. 32 Pages: 472-478
  • Peer Reviewed
• [Journal Article] Facilitation of Applicability in Ice Chromatography by Mechanistic Considerations and by Preparation of Fine Water-ice Stationary Phase (2009)
  • Author(s): Y.Tasaki, T.Okada
  • Journal Title: Anal.Chem. 81 Pages: 890-897
  • Peer Reviewed
• [Journal Article] Multivariate Analysis of DSC-XRD Simultaneous Measurement Data : a Study of Multistage Crystalline Structure Changes in a Linear Poly(ethylene imine)Thin Film (2009)
  • Author(s): H. Kakuda, T. Okada, M. Otsuka, Y. Katsumoto, T. Hasegawa
  • Journal Title: Analytical and Bioanalytical Chemistry 393 Pages: 367-376
  • Peer Reviewed
• [Journal Article] Electrophoretic Levitation of Particles by Field Switching (2009)
  • Author(s): M. Yamada, M. Harada. T. Okada
  • Journal Title: Analytical Sciences 25 Pages: 279-284
  • Peer Reviewed
• [Journal Article] Wide-bore Hydrodynamic Chromatography in Sub-second Range (2009)
  • Author(s): R. Umehara, M. Harada, T. Okada
  • Journal Title: Journal of Separation Science 32 Pages: 472-478
  • Peer Reviewed
• [Journal Article] Consideration of Ion Recognition Selectivity Based on Hydration of Ions in Confined Spaces (2009)
  • Author(s): T. Okada, T. Ohki, M. Harada
  • Journal Title: Analytical Sciences 25 Pages: 167-175
  • Peer Reviewed
• [Journal Article] 氷の化学-宇宙や地球環境でも注目されている物性と機能 (2009)
  • Author(s): 岡田哲男
  • Journal Title: 化学 64 Pages: 68-69
• [Journal Article] 有機イオン交換体対イオンの水和 (2009)
  • Author(s): 岡田哲男
  • Journal Title: 高分子 58 Pages: 87-87
  • NAID: 10024759136
• [Journal Article] Ice Chromatographic Characterization of Thin Liquid Layer at the Interface between Water-ice and Organic Solvent (2008)
  • Author(s): Y.Tasaki, T.Okada
  • Journal Title: J.Phys.Chem.C 112 Pages: 2618-2623
  • Peer Reviewed
• [Journal Article] Ice Chromatography. Modification of Solute Retention on Water-ice Stationary Phase (2008)
  • Author(s): Y.Tasaki, T.Okada
  • Journal Title: J.Chromatogr.A 1189 Pages: 72-76
  • Peer Reviewed
• [Journal Article] Hydration of Counterions in Cation-Exchange Resins Studied by X-ray Absorption Fine Structure (2008)
  • Author(s): M.Harada, T.Okada
  • Journal Title: Chem. Commun. Pages: 5182-5184
  • Peer Reviewed
• [Journal Article] Perturbation of Second and Farther Hydration Shells of Alkali Cations and Bromide in Concentrated Aqueous Protein as a Water-Shortage Medium (2008)
  • Author(s): T.Ohki, M. Harada, T.Okada
  • Journal Title: J.Phys.Chem.B 112 Pages: 11863-11867
  • Peer Reviewed
• [Journal Article] Anisotropic Molecular Structure in Dip-Coated Films of Linear Poly(ethylene imine) Studied by Infrared Multiple-Angle Incidence Resolution Spectrometry (2008)
  • Author(s): H.Kakuda, T.Okada, T.Hasegawa
  • Journal Title: J.Phys.Chem.B 112 Pages: 12940-12945
  • Peer Reviewed
• [Journal Article] Ice Chromatography. Modification of Solute Retention on Water-ice Stationary Phase (2008)
  • Author(s): Y. Tasaki, T. Okada
  • Journal Title: Journal of Chromatography A 1189 Pages: 72-76
  • Peer Reviewed
• [Journal Article] Hydration of Counterions in Cation-Exchange Resins Studied by X-ray Absorption Fine Structure (2008)
  • Author(s): M. Harada, T. Okada
  • Journal Title: Chemical Communications Pages: 5182-5184
  • Peer Reviewed
• [Journal Article] Perturbation of Second and Farther Hydration Shells of Alkali Cations and Bromide in Concentrated Aqueous Protein as a Water-Shortage Medium (2008)
  • Author(s): T. Ohki, M. Harada, T. Okada
  • Journal Title: Journal of Physical Chemistry B 112 Pages: 11863-11867
  • Peer Reviewed
• [Journal Article] Anisotropic Molecular Structure in Dip-Coated Films of Linear Poly(ethylene imine) Studied by Infrared Multiple-Angie Incidence Resolution Spectrometry" (2008)
  • Author(s): H. Kakuda, T. Okada, T. Hasegawa
  • Journal Title: Journal of Physical Chemistry B 112 Pages: 12940-12945
  • Peer Reviewed
• [Journal Article] 新しい分離場の設計と分析化学的展開 (2008)
  • Author(s): 岡田哲男, 田崎友衣子
  • Journal Title: 分析化学 57 Pages: 921-935
  • NAID: 110007008601
  • Peer Reviewed
• [Journal Article] Acoustic Recognition of Counterions in Ion-exchange Resins (2007)
  • Author(s): S.Hirawa, T.Masudo, T.Okada
  • Journal Title: Anal.Chem. 79 Pages: 3003-3007
  • Peer Reviewed
• [Journal Article] Microparticle Separation with Acoustic-gravity Field Controlled by Phase-shift Operation (2007)
  • Author(s): T.Masudo, T.Okada
  • Journal Title: Anal.Sci. 23 Pages: 385-387
  • NAID: 10018914096
  • Peer Reviewed
• [Journal Article] Structural and Thermodynamic Aspects of Ionic Solvation in Concentrated Aqueous Poly(ethylene glycol) (2007)
  • Author(s): T.Ohki, M. Harada, T.Okada
  • Journal Title: J.Phys.Chem.B 111 Pages: 7245-7252
  • Peer Reviewed
• [Journal Article] Characterization of Bromide Ions in Charge-stacked Zwitterionic Micellar Systems (2007)
  • Author(s): T.Aoki, M.Harada, T.Okada
  • Journal Title: Langmuir 23 Pages: 8820-8826
  • Peer Reviewed
• [Journal Article] Hydration Structures of Bromides on Cationic Micelles (2007)
  • Author(s): M.Harada, H.Satou, T.Okada
  • Journal Title: J.Phys.Chem.B 111 Pages: 12136-12140
  • Peer Reviewed
• [Journal Article] Electrolyte-Induced Phase Separation and Charge Reversal of Cationic Zwitterionic Micelles (2007)
  • Author(s): T.Aoki, M.Harada, T.Okada
  • Journal Title: Langmuir 23 Pages: 12473-12477
  • Peer Reviewed
• [Journal Article] Inhibition of Aggregation of a Biomimic Peptidolipid Langmuir Monolayer by Congo Red Studied by UV-Vis and IR Spectroscopies (2007)
  • Author(s): T.Hasegawa, Y.Sato, T.Okada, M.Shibukawa, C.Li, J.Orbulescu, R.Leblanc
  • Journal Title: J.Phys.Chem.B 111 Pages: 14227-14232
  • Peer Reviewed
• [Journal Article] Acoustic Recognition of Counterions in lon-exchange Resins (2007)
  • Author(s): S. Hirawa, T. Masudo, T. Okada
  • Journal Title: Analytical Chemistry 79 Pages: 3003-3007
  • Peer Reviewed
• [Journal Article] Microparticle Separation with Acoustic-gravity Field Controlled by Phase-shift Operation (2007)
  • Author(s): T. Masudo, T. Okada
  • Journal Title: Analytical Sciences 23 Pages: 385-387
  • NAID: 10018914096
  • Peer Reviewed
• [Journal Article] Structural and Thermodynamic Aspects of Ionic Solvation in Concentrated Aqueous Poly (ethylene glycol) (2007)
  • Author(s): T. Ohki, M. Harada, T. Okada
  • Journal Title: Journal of Physical Chemistry B 111 Pages: 7245-7252
  • Peer Reviewed
• [Journal Article] Characterization of Bromide Ions in Charge-stacked Zwitterionic Micellar Systems (2007)
  • Author(s): T. Aoki, M. Harada, T. Okada
  • Journal Title: Langmuir 23 Pages: 8820-8826
  • Peer Reviewed
• [Journal Article] Electrolyte-Induced Phase Separation and Charge Reversal of Cationic Zwitterionic Micelles (2007)
  • Author(s): T. Aoki, M. Harada, T. Okada
  • Journal Title: Langmuir 23 Pages: 12473-12477
  • Peer Reviewed
• [Journal Article] Hydration Structures of Bromides on Cationic Micelles (2007)
  • Author(s): M. Harada, H. Satou, T. Okada
  • Journal Title: Journal of Physical Chemistry B 111 Pages: 12136-12140
  • Peer Reviewed
• [Journal Article] Inhibition of Aggregation of a Biomimic Peptidolipid Langmuir Monolayer by Congo Red Studied by UV-Vis and Infrared Spectroscopies (2007)
  • Author(s): T. Hasegawa, Y. Sato, T. Okada, M. Shibukawa, C. Li, J. Orbulescu, R. Leblanc
  • Journal Title: Journal of Physical Chemistry B 111 Pages: 14227-14232
  • Peer Reviewed
• [Journal Article] Evaluation of Ion-exchange Reaction by Coupled Acoustic-gravity Field (2007)
  • Author(s): S. Hirawa, T. Okada
  • Journal Title: Journal of Ion Exchange 18 Pages: 10-13
  • NAID: 130004162409
  • Peer Reviewed
• [Journal Article] Solvation of Ions in Aqueous Hydrophilic Polymer Solutions (2007)
  • Author(s): T. Ohki, M. Harada, T. Okada
  • Journal Title: Journal of Ion Exchange 18 Pages: 6-9
  • NAID: 130004162408
  • Peer Reviewed
• [Journal Article] Liquid-core Waveguide in Capillary Electrophoresis (2007)
  • Author(s): T. Okada
  • Journal Title: Electrophoresis 28 Pages: 3414-3419
  • Peer Reviewed
• [Journal Article] Ice Chromatography. Characterization of Water-ice as a Chromatographic Stationary Phase (2006)
  • Author(s): Y.Tasaki, T.Okada
  • Journal Title: Anal.Chem. 78 Pages: 4155-4160
  • Peer Reviewed
• [Journal Article] Kinetic Monitoring of Electrophoretically Induced Solute Reaction by Axial Absorption Detection with Liquid-core Waveguide (2006)
  • Author(s): A.Wada, M.Harada, T.Okada
  • Journal Title: Anal.Chem. 78 Pages: 4709-4712
  • Peer Reviewed
• [Journal Article] Structures of 18-crown-6 Complexes with Alkali Cations in Methanolic Solution as Studied by X-ray Absorption Fine Structure (2006)
  • Author(s): M.Harada, T.Okada
  • Journal Title: J.Solun.Chemi. 35 Pages: 1645-1654
  • Peer Reviewed
• [Journal Article] Solvation of Ions in Hydrophilic Layer of Polyoxyethylated Nonionic Micelle. Cooperative Approach by Electrophoresis and Ion-transfer Voltammetry (2006)
  • Author(s): T.Ohki, M. Harada, T.Okada
  • Journal Title: J.Phys.Chem.B 110 Pages: 15486-15492
  • Peer Reviewed
• [Journal Article] Analysis of Structurally Heterogeneous Langmuir-Blodgett Films of Folded/Unfolded Long-Chain Molecules by Infrared Multiple-Angle Incidence Resolution Spectroscopy (2006)
  • Author(s): T.Hasegawa, Y.Iiduka, H.Kakuda, T.Okada
  • Journal Title: Anal.Chem. 78 Pages: 6121-6125
  • Peer Reviewed
• [Journal Article] Analysis of Gibbs Monolayer Adsorbed at the Toluene/Water Interface by UV-Visible Partial Internal Reflection Spectrometry (2006)
  • Author(s): Y.Moriya, T.Hasegawa, T.Okada, N.Ogawa, E.Kawai, K.Abe, M.Ogasawara, S.Kato, S.Nakata
  • Journal Title: Anal.Chem. 78 Pages: 7850-7856
  • Peer Reviewed
• [Journal Article] Low-capacity Channel Designed for Particle Separation with Controlled Electric Fields and Evaluation of Involved Forces (2006)
  • Author(s): Takashi Masudo, Tetsuo Okada
  • Journal Title: Journal of Chromatography A 1106 Pages: 196-204
• [Journal Article] Ice Chromatography. Characterization of Water-ice as a Chromatographic Stationary Phase (2006)
  • Author(s): Yuiko Tasaki, Tetsuo Okada
  • Journal Title: Analytical Chemistry 78 Pages: 4155-4160
• [Journal Article] Kinetic Monitoring of Electrophoretically Induced Solute Reaction by Axial Absorption Detection with Liquid-core Waveguide (2006)
  • Author(s): Akira Wada, Makoto Harada, Tetsuo Okada
  • Journal Title: Analytical Chemistry 78 Pages: 4709-4712
• [Journal Article] Structures of 18-crown-6 Complexes with Alkali Cations in Methanolic Solution as Studied by X-ray Absorption Fine Structure (2006)
  • Author(s): Makoto Harada, Tetsuo Okada
  • Journal Title: Journal of Solution Chemistry 35, Pages: 1645-1654
• [Journal Article] Solvation of Ions in Hydrophilic Layer of Polyoxyethylated Nonionic Micelle. Cooperative Approach by Electrophoresis and Ion-transfer Voltammetry (2006)
  • Author(s): Takumi Ohki, Makoto Harada, Tetsuo Okada
  • Journal Title: Journal of Physical Chemistry B 110 Pages: 15486-15492
• [Journal Article] Analysis of Structurally Heterogeneous Langmuir-Blodgett Films of Folded/Unfolded Long-Chain Molecules by Infrared Multiple-Angle Incidence Resolution Spectroscopy (2006)
  • Author(s): Takeshi Hasegawa, Yu Iiduka, Hiroyuki Kakuda, Tetsuo Okada
  • Journal Title: Analytical Chemistry 78 Pages: 6121-6125
• [Journal Article] Analysis of Gibbs Monolayer Absorbed at the Toluene/Water Interface by UV-Visible Partial Internal Reflection Spectrometry (2006)
  • Author(s): Yoshio Moriya, Takeshi Hasegawa, Tetsuo Okada, Nobuaki Ogawa, Erika Kawai, Kosuke Abe, Masataka Ogasawara, Sumio Kato, Shinichi Nakata
  • Journal Title: Analytical Chemistry 78 Pages: 7850-7856
• [Journal Article] Particle Separation with Ultrasound Radiation Force (2006)
  • Author(s): Takashi Masudo, Tetsuo Okada
  • Journal Title: Current Analytical Chemistry 2 Pages: 213-227
• [Journal Article] 超音波を用いる粒子分離 (2006)
  • Author(s): 岡田哲男
  • Journal Title: ぶんせき Pages: 524-525
  • NAID: 10018320689
• [Presentation] Water-ice for Developing Novel Analytical Methodology (2008)
  • Author(s): TOkada
  • Organizer: HPLC Kyoto 2008
  • Place of Presentation: Kyoto
  • Year and Date: 2008-12-05
• [Presentation] Water-ice for Developing Novel Analytical Methodology (2008)
  • Author(s): T. Okada
  • Organizer: HPLC Kyoto 2008
  • Place of Presentation: 京都大学(桂キャンパス)
  • Year and Date: 2008-12-05
• [Presentation] Adsorption/Partition Mode Switchng in Ice Chromatography by Utilizing Phase Equilibrium in NaCl- or KCl-Water System (2008)
  • Author(s): Y.Tasaki, TOkada
  • Organizer: HPLC Kyoto 2008
  • Place of Presentation: Kyoto
  • Year and Date: 2008-12-03
• [Presentation] Ice Chromatography. A New Physicochemical Approach to Water-ice Surface (2008)
  • Author(s): Y.Tasaki, TOkada
  • Organizer: International Snow Science Workshop Whistler 2008
  • Place of Presentation: Whistler, Canada
  • Year and Date: 2008-09-23
• [Presentation] Hydration of Counterions in Ion-exchange Resin Polyelectrolytes (2008)
  • Author(s): TOkada, M.Harada, T.Ohki
  • Organizer: 20Ice Chromatography ; A Probe of Molecular Interactions on Water-ice Surface and Its Potential in Practival Separation
  • Place of Presentation: Coimbra, Portugal
  • Year and Date: 2008-06-19
• [Presentation] Hydration of Counterions in Ion-exchange Resin (2008)
  • Author(s): T. Okada, M. Harada, T. Ohki
  • Organizer: Polyelectrolytes 2008
  • Place of Presentation: Coimbra, Portugal
  • Year and Date: 2008-06-19
• [Presentation] Ice Chromatography ; A Probe of Molecular Interactions on Water-ice Surface and Its Potential in Practival Separation (2008)
  • Author(s): Y.Tasaki, TOkada
  • Organizer: 8th Csaba Horvath Medal Award Symposium
  • Place of Presentation: Innsbruck, Austria
  • Year and Date: 2008-04-15
• [Presentation] Solvation of Ions in Aqueous Hydrophilic Polymer Solutions (2007)
  • Author(s): T.Ohki, M.Harada, TOkada
  • Organizer: 4th International Conference on Ion Exchange ICIE'07
  • Place of Presentation: Chiba
  • Year and Date: 2007-10-18
• [Presentation] Evaluation of Ion-exchange Reaction by Coupled Acoustic-gravity Field (2007)
  • Author(s): S.Hirawa, TOkada
  • Organizer: 4th International Conference on Ion Exchange ICIE'07
  • Place of Presentation: Chiba
  • Year and Date: 2007-10-16
• [Presentation] Ice Chromatography (2007)
  • Author(s): Y.Tasaki, TOkada
  • Organizer: 4th International Conference on Ion Exchange ICIE'07
  • Place of Presentation: Chiba
  • Year and Date: 2007-10-16
• [Presentation] Acoustic Evaluation of Ion-exchange (2007)
  • Author(s): S.Hirawa, TOkada
  • Organizer: 19th International Congress on Acoustics
  • Place of Presentation: Madrid, Spain
  • Year and Date: 2007-09-03
• [Presentation] Acoustic Evaluation of Ion-exchange (2007)
  • Author(s): S. Hirawa, T. Okada
  • Organizer: 19th INTERNATIONAL CONGRESS ON ACOUSTICS
  • Place of Presentation: Madrid, Spain
  • Year and Date: 2007-09-03
• [Presentation] Separation selectivity of charge-imbalanced zwitterionic stationary phase (2007)
  • Author(s): X.Yang, T.Aoki, T.Okada
  • Organizer: HPLC 2007
  • Place of Presentation: Ghent , Belgium
  • Year and Date: 2007-06-19
• [Presentation] Ice Chromatography (2007)
  • Author(s): Y.Tasaki, TOkada
  • Organizer: HPLC 2007
  • Place of Presentation: Ghent (Belgium)
  • Year and Date: 2007-06-19
• [Presentation] Separation selectivity of charge-imbalanced zwitterionic stationary phase (2007)
  • Author(s): X. Yang, T. Aoki, T. Okada
  • Organizer: HPLC 2007
  • Place of Presentation: Gent, Belgium
  • Year and Date: 2007-06-19
• [Presentation] Selectivity in Binding of Anions by Zwitterionic Micelles (2006)
  • Author(s): T.Aoki, T.Okada, M.Harada
  • Organizer: International Symposium on Ion Exchange in Korea and the 22nd Annual Meeting of JAIE
  • Place of Presentation: Seoul, Republic of Korea
  • Year and Date: 2006-10-19
• [Presentation] Acoustic Recognition of Counterions in Ion-exchange Resins (2006)
  • Author(s): S.Hirawa, T.Masudo, TOkada
  • Organizer: International Symposium on Ion Exchange in Korea and the 22nd Annual Meeting of JAIE
  • Place of Presentation: Seoul, Republic of Korea
  • Year and Date: 2006-10-19
• [Book] 新しい地平をひらく分析手法の最前線(北森武彦編) (2009)
  • Author(s): 岡田哲男(分担執筆)
  • Publisher: 化学同人(京都)
• [Book] 図解 最先端イオン交換技術のすべて(神崎〓監修)(日本イオン交換学会編) (2009)
  • Author(s): 岡田哲男(編集、分担執筆)
  • Publisher: 日工業調査会(東京)
• [Book] Particle Size Separation/ Field Flow Fractionation : Electric Fields. In "Encyclopedia of Separation Science, online update(Colin F. Poole and Ian D. Wilson, (Editors-in-Chief)) (2007)
  • Author(s): T.Okada
  • Publisher: Oxford : Elsevier Science Ltd.
• [Remarks] 微小な氷を使って分子をわける,「月刊化学(化学同人)」最新のトピックス・注目の論文(2007年12月)
• [Remarks] Ice cold in the lab, Separations NOW(2006年6月)
  • URL: http://www.separationsnow.com
• [Remarks] Cool Separations, American Chemical Society(2006年6月)
  • URL: http://www.chemistry.org/portal
• [Remarks] Ice Age, Separations NOW(2009年2月)
  • URL: http://www.separationsnow.com
• [Remarks] 氷を使って光ファイバー型の分析セルを作る, 日本分析化学会第57 年会「展望とトピックス」(2008年p.17)
• [Remarks] The Ice Men Cometh, LCGC Europe(2009年2月)
  • URL: http://chromatographyonline.finanalytichem.com
• [Remarks] Lab on Ice, Chemical Technology, 6(5), T35(2009)