Innovation of Biomedical Engineering by Heat Transfer Control-Challenge to the Quality of Life-

• Project/Area Number: 18206022
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Thermal engineering
• Research Institution: Tohoku University
• Principal Investigator: MARUYAMA Shigenao Tohoku University, 流体科学研究所, 教授 (80173962)
• Co-Investigator(Kenkyū-buntansha): YAMBE Tomoyuki 東北大学, 加齢医学研究所, 教授 (70241578) ; AIBA Setsuya 東北大学, 大学院・医学系研究科, 教授 (80159269) ; TOMINAGA Teiji 東北大学, 大学院・医学系研究科, 教授 (00217548) ; KOMIYA Atsuki 東北大学, 流体科学研究所, 講師 (60371142)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥46,540,000 (Direct Cost: ¥35,800,000、Indirect Cost: ¥10,740,000); Fiscal Year 2008: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000); Fiscal Year 2007: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000); Fiscal Year 2006: ¥25,090,000 (Direct Cost: ¥19,300,000、Indirect Cost: ¥5,790,000)
• Keywords: 温熱制御 / ペルチェ素子 / 凍結治療 / てんかん治療 / 皮膚治療 / クライオプローブ / 脳冷却 / 脳マッピング / 凍結手術

Research Abstract

本研究では、高精度伝熱制御技術を用いた治療ついて検討を行うとともに、その技術確立を図った。高精度皮膚凍結手術用冷却装置を開発し、動物実験により到達温度と細胞壊死との関係を定量的に評価した。また、微小領域凍結手術に向けた微小クライオプロ-ブを開発し、脳機能マッピングを高精度に行うための脳冷却マッピング法を提案した。
温熱療法においては、臨床現場における安全性を確保し、効率的に治療を行うことを目指し、接触型加熱円盤装置、ふく射加熱装置の二種類の治療装置を開発しその評価を行った。

Research Products

• [Journal Article] The Flexible Cryoprobe Using Peltier Effect for Heat Transfer Control (2008)
  • Author(s): S. Maruyama, K. Nakagawa, H. Takeda, S. Aiba and A. Komiya
  • Journal Title: Journal of Biomechanical Science and Engineering Vol.3 Pages: 138-150
  • NAID: 130000079480
  • Peer Reviewed
• [Journal Article] Estimation of Temperature Distribution in Biological Tissue by Using Solutions of Bioheat Transfer Equation (2008)
  • Author(s): S. Maruyama, J. Okajima, A. Komiya and H. Takeda
  • Journal Title: Heat Transfer-Asian Research Vol.37 Pages: 374-386
  • NAID: 110006402881
  • Peer Reviewed
• [Journal Article] Estimation of Temperature Distribution in Biological Tissue by Using Solutions of Bioheat Transfer Equation (2008)
  • Author(s): S. Maruyama, J. Okajima, A. Komiva, and H. Takeda
  • Journal Title: Heat Transfer-Asian Research 37 Pages: 374-386
  • NAID: 110006402881
  • Peer Reviewed
• [Journal Article] The Flexible Cryoprobe Using Peltier Effect for Heat Transfer Control (2008)
  • Author(s): S. Maruyama, K. Nakagawa, H. Takeda, S. Aiba, A. Komiya
  • Journal Title: Journal of Biomechanical Science and Engineering 3 Pages: 138-150
  • NAID: 130000079480
  • Peer Reviewed
• [Journal Article] 生体伝熱方程式の解析解による生体組織内温度分布の推定 (2007)
  • Author(s): 円山重直、岡島淳之介、小宮敦樹、武田洋樹
  • Journal Title: 日本機械学会論文集(B編) 733 Pages: 1899-1905
  • NAID: 110006402881
  • Peer Reviewed
• [Journal Article] 生体伝熱方程式の解析解による生体組織内温度分布の推定 (2007)
  • Author(s): 円山重直、岡島淳之介、小宮敦樹、武田洋樹
  • Journal Title: 日本機械学会論文集(B編) 73号,733巻 Pages: 1899-1905
  • NAID: 110006402881
  • Peer Reviewed
• [Journal Article] Brain Mapping Method Utilizing Rapid Cooling Probe (2006)
  • Author(s): S.Maruyama, 他 4 名
  • Journal Title: Proceedings of the 17th International Symposium on Transport Phenomena (CD-ROM)
• [Journal Article] Solution of Bio-heat Transfer Equation during Thermal Therapies (2006)
  • Author(s): J.Okajima, 他 2 名
  • Journal Title: Proceedings of the Third International Conference on Flow Dynamics Pages: 115-116
• [Journal Article] Inactivation of Brain Function Utilizing Rapid Cooling Probe Applied to Brain Mapping (2006)
  • Author(s): H.Takeda, 他 4 名
  • Journal Title: Proceedings of the Third International Conference on Flow Dynamics Pages: 203-204
• [Journal Article] Analytical Study of Temperature Distribution in Biological Tissue (2006)
  • Author(s): J.Okajima, 他 2 名
  • Journal Title: Proceedings of the 15th International Conference on Mechanics in Medicine and Biology Pages: 403-406
• [Presentation] 温度制御された黒体炉とふく射伝熱解析による放射温度計の高精度計測(Vol.34) (2009)
  • Author(s): 小笠原直也・円山重直・小宮敦樹
  • Organizer: 日本機械学会東北支部第44期総会・講演会
  • Place of Presentation: 仙台
  • Year and Date: 2009-03-13
• [Presentation] 温度制御された黒体炉とふく射伝熱解析による放射温度計の高精度計測 (2009)
  • Author(s): 小笠原直也・円山重直・小宮敦樹
  • Organizer: 日本機械学会東北支部第44期総会・講演会
  • Place of Presentation: 仙台
  • Year and Date: 2009-03-13
• [Presentation] Heat-transfer Control of Biological Tissue Utilizing Non-equilibrium Thermo-electric Device for Precise Cryosurgery (2008)
  • Author(s): S. Maruyama, H. Takeda and A. Komiya
  • Organizer: The 35th Annual Meeting of the Japan Society for Low Temperature Medicine
  • Place of Presentation: Tokyo
  • Year and Date: 2008-11-22
• [Presentation] Simple yet Precise Calibration Method of Thermometers for Measuring the Temperature of Biological Tissue (2008)
  • Author(s): N. Ogasawara, S. Maruyama, A. Komiya, H. Takeda, T. Seki and T. Yambe
  • Organizer: Fifth International Conference on Flow Dynamics
  • Place of Presentation: Sendai
  • Year and Date: 2008-11-18
• [Presentation] Simple yet Precise Calibration Method of Thermometers for Measuring the Temperature of Biological Tissue (2008)
  • Author(s): N. Ogasawara, S. Maruyama, A. Komiya, H. Takeda, T. Seki and T. Yambe
  • Organizer: Fifth International Conference on Flow Dynamics
  • Place of Presentation: Sendai, Japan
  • Year and Date: 2008-11-18
• [Presentation] Evaluation of the Peltier Cryoprobe Availability through Animal Experiments (2008)
  • Author(s): H. Takeda, S. Aiba, J. Okajima, A. Komiya and S. Maruyam
  • Organizer: Fifth International Conference on Flow Dynamics
  • Place of Presentation: Sendai, Japan
  • Year and Date: 2008-11-18
• [Presentation] Evaluation of the Peltier Cryoprobe Availability through Animal Experiments (2008)
  • Author(s): H. Takeda, S. Aiba, J. Okajima, A. Komiya and S. Maruyama
  • Organizer: Fifth International Conference on Flow Dynamics
  • Place of Presentation: Sendai
  • Year and Date: 2008-11-08
• [Presentation] Development of Precise Heat Transfer Control Devices for Thermal Therapy (2008)
  • Author(s): S. Takashima, N. Ogasawara, S. Maruyama, A. Komiya, T. Seki and T. Yambe
  • Organizer: The Second International Forum on Heat Transfer
  • Place of Presentation: Tokyo
  • Year and Date: 2008-09-19
• [Presentation] Development of Precise Heat Transfer Control Devices for Thermal Therapy (2008)
  • Author(s): S. Takashima, N. Ogasawara, S. Maruyama, A. Komiya, T. Seki antl T. Yambe
  • Organizer: The Second International Forum on Heat Transfer
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2008-09-19
• [Presentation] Precise Control of Cooling and Heating Rate Utilizing Peltier Cryoprobe for Cryosurgery (2008)
  • Author(s): H. Takeda, S. Maruyama, J. Okajima, S. Aiba and A. Komiya
  • Organizer: The 19th International Symposium on Transport Phenomena
  • Place of Presentation: Reykjavik, Iceland
  • Year and Date: 2008-08-19
• [Presentation] Possibility of Micro-cryosurgery Utilizing Cooling Needle (2008)
  • Author(s): J. Okajima, A. Komiya, H. Takeda and S. Maruyama
  • Organizer: The XVIth International Conference on Mechanics in Medicine and Biology
  • Place of Presentation: Pittsburgh, USA
  • Year and Date: 2008-07-25
• [Presentation] Possibility of Micro-cryosurgery Utilizing Cooling Needle (2008)
  • Author(s): J. Okajima, A. Komiya, H. Takeda and S. Maruyama
  • Organizer: the XVIth International Conference on Mechanics in Medicine and Biology
  • Place of Presentation: Pittsburgh, US
  • Year and Date: 2008-07-25
• [Presentation] Development of Precise-temperature- controlled Cooling Apparatus for Medical Application by Using Peltier Effect (2008)
  • Author(s): S. Maruyama, A. Komiya, H. Takeda and S. Aiba
  • Organizer: 2008 International Conference on BioMedical Engineering and Informatics
  • Place of Presentation: Hainan, China
  • Year and Date: 2008-05-29
• [Presentation] Development of Precise-temperature- controlled Cooling Apparatus for Medical Application by Using Peltier Effect (2008)
  • Author(s): S. Maruyama, A. Komiya, H. Takeda and S. Aiba
  • Organizer: 2008 International Conference on BioMedical Enaineerine and Informatics
  • Place of Presentation: Hainan, China
  • Year and Date: 2008-05-29
• [Presentation] ふく射加熱装置を用いた熱流束制御による温熱療法への応用 (2008)
  • Author(s): 小笠原直也・円山重直・高島茂・小宮敦樹・関隆志・山家智之
  • Organizer: 第45回日本伝熱シンポジウム
  • Place of Presentation: つくば
  • Year and Date: 2008-05-23
• [Presentation] ペルチェクライオプロ-ブを用いた伝熱制御および凍結領域の制御に関する研究 (2008)
  • Author(s): 武田洋樹・円山重直・岡島淳之介・小宮敦樹・相場節也
  • Organizer: 第45回日本伝熱シンポジウム
  • Place of Presentation: つくば
  • Year and Date: 2008-05-23
• [Presentation] ペルチェクライオプローブを用いた伝熱制御および凍結領域の制御に関する研究 (2008)
  • Author(s): 武田洋樹・円山重直・岡島淳之介・小宮敦樹・相場節也
  • Organizer: 第45回日本伝熱シンポジウム
  • Place of Presentation: つくば
  • Year and Date: 2008-05-23
• [Presentation] 微小凍結手術用冷却針による生体組織凍結現象の解析 (2008)
  • Author(s): 岡島淳之介・武田洋樹・小宮敦樹・円山重直
  • Organizer: 第45回日本伝熱シンポジウム
  • Place of Presentation: つくば
  • Year and Date: 2008-05-21
• [Presentation] 温熱療法に向けたふく射加熱装置の伝熱制御による性能評価 (2008)
  • Author(s): 小笠原直也・円山重直・高島茂・小宮敦樹・関隆志・山家智之
  • Organizer: 第8回日本伝熱学会東北支部学生発表会
  • Place of Presentation: 仙台
  • Year and Date: 2008-05-09
• [Presentation] 腹部温熱制御機器を用いた温熱療法の伝熱制御 (2008)
  • Author(s): 高島茂・円山重直・小宮敦樹・小笠原直也・関隆志・山家智之
  • Organizer: 日本機械学会東北支部第43期総会・講演会
  • Place of Presentation: 仙台
  • Year and Date: 2008-03-15
• [Presentation] Precise Temperature Control and Heat Flux Measurement of The Radiation Heater for Thermal Therapy (2007)
  • Author(s): N. Ogasawara, S. Maruyama, S. Takashima, A. Komiya, T. Seki and T. Yambe
  • Organizer: the Seventh International Symposium on Advanced Fluid Information and the Forth International Symposium on Trandisciplinary Fluid Information
  • Place of Presentation: 仙台
  • Year and Date: 2007-12-15
• [Presentation] Precise Temperature Control and Heat Flux Measurement of The Radiation Heater for Thermal Therapy (2007)
  • Author(s): N. Ogasawara, S. Maruyama, S. Takashima, A. Komiya, T. Seki and T. Yambe
  • Organizer: AFI/TFI-2007
  • Place of Presentation: Sendai
  • Year and Date: 2007-12-14
• [Presentation] Prediction of Frozen Region by Numerical Simulation during Cryosurgery Utilizing Peltier Cryoprobe (2007)
  • Author(s): H. Takeda, S. Maruyama, S. Aiba and A. Komiya
  • Organizer: Fourth International Conference on-Flow Dynamics
  • Place of Presentation: Sendai
  • Year and Date: 2007-09-27
• [Presentation] Measurement of Heat Flux Emitted by Radiation Heater for Thermal Therapy (2007)
  • Author(s): N. Ogasawara, S. Takashima, S. Maruyama, A. Komiya, T. Seki and T. Yambe
  • Organizer: Fourth International Conference on Flow Dynamics
  • Place of Presentation: Sendai
  • Year and Date: 2007-09-27
• [Presentation] Measurement of Heat Flux Emitted by Radiation Heater for Thermal Therapy (2007)
  • Author(s): N. Ogasawara, S. Takashima, S. Maruyama, A. Komiya, T. Seki and T. Yambe
  • Organizer: Fourth International Conference on Flow Dynamics
  • Place of Presentation: 仙台
  • Year and Date: 2007-09-27
• [Presentation] Prediction of Frozen Region by Numerical Simulation during Cryosurgery Utilizing Peltier Cryoprobe (2007)
  • Author(s): H. Takeda, S. Maruyama, S. Aiba, A. Komiya
  • Organizer: Fourth International Conference on Flow Dynamics
  • Place of Presentation: 仙台
  • Year and Date: 2007-09-27
• [Presentation] Evaluation of the Relation between Frozen Regions and Heat Transfer (2007)
  • Author(s): J. Okajima, S. Maruyama and A. Komiya
  • Organizer: Fourth International Conference on Flow Dynamics
  • Place of Presentation: Sendai
  • Year and Date: 2007-09-26
• [Presentation] Evaluation of the Relation between Frozen Regions and Heat Transfer (2007)
  • Author(s): J. Okajima, S. Maruyama, and A. Komiya
  • Organizer: Fourth International Conference on Flow Dynamics
  • Place of Presentation: 仙台
  • Year and Date: 2007-09-26
• [Presentation] Precise Control of Frozen Region during Cryosurgery Utilizing Peltier effect (2007)
  • Author(s): H. Takeda, S. Maruyama, S. Aiba and A. Komiya
  • Organizer: The ASME-JSME 2007 Thermal Engineering and Summer Heat Transfer Conference
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2007-07-11
• [Presentation] Precise Control of Frozen Region during Cryosurgery Utilizing Peltier effect (2007)
  • Author(s): H. Takeda, S. Maruyama, S. Aiba and A. Komiya
  • Organizer: The ASME-JSME 2007 Thermal Engineering and Summer Heat Transfer Conference
  • Place of Presentation: バンクーバー,カナダ
  • Year and Date: 2007-07-11
• [Presentation] 腹部温熱制御機器を用いた生体内伝熱に関する研究 (2007)
  • Author(s): 円山重直, 高島茂, 武田洋樹, 岡島淳之介, 小宮敦樹, 関隆志, 山家智之
  • Organizer: 第44回日本伝熱学会シンポジウム
  • Place of Presentation: 長崎
  • Year and Date: 2007-05-23
• [Presentation] 腹部温熱制御機器を用いた生体内伝熱に関する研究(第一巻) (2007)
  • Author(s): 円山重直, 高島茂, 武田洋樹, 岡島淳之介, 小宮敦樹, 関隆志, 山家智之
  • Organizer: 第44回日本伝熱学会シンポジウム
  • Place of Presentation: 長崎
  • Year and Date: 2007-05-22
• [Presentation] 腹部温熱制御機器による生体内非定常温度分布の数値解析 (2007)
  • Author(s): 高島茂, 円山重直, 武田洋樹, 岡島淳之介, 小宮敦樹, 関隆志, 山家智之
  • Organizer: 日本伝熱学会東北支部第7回日本伝熱学会学生発表会
  • Place of Presentation: 仙台
  • Year and Date: 2007-05-11
• [Presentation] Analytical Study of Temperature Distribution in Biological Tissue (2006)
  • Author(s): J. Okajima, S. Maruyama and A. Komiya
  • Organizer: Proceedings of the 15th International Conference on Mechanics in Medicine and Biology
  • Place of Presentation: Singapore
  • Year and Date: 2006-12-08
• [Presentation] Inactivation of Brain Function Utilizing Rapid Cooling Probe Applied to Brain Mapping (2006)
  • Author(s): H. Takeda, S. Maruyama, A. Komiya, T. Yambe and N. Nakasato
  • Organizer: Proceedings of Third International Conference on Flow Dynamics
  • Place of Presentation: Sendai
  • Year and Date: 2006-11-09
• [Presentation] Solution of Bio-heat Transfer Equation duringn Thermal Therapies (2006)
  • Author(s): J. Okajima, S. Maruyama and A. Komiya
  • Organizer: Proceedings of Third International Conference on Flow Dynamics
  • Place of Presentation: Sendai
  • Year and Date: 2006-11-08
• [Presentation] Brain Mapping Method Utilizing Rapid Cooling Probe (2006)
  • Author(s): S. Maruyama, H. Takeda, A. Komiya, T. Yambe and N. Nakasato
  • Organizer: Proceedings of the 17th International Symposium on Transport Phenomena
  • Place of Presentation: Toyama
  • Year and Date: 2006-09-05