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Development of artificial receptor-based amplification system of dendritic cells for cancer therapy

Research Project

Project/Area Number 18206083
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Biofunction/Bioprocess
Research InstitutionThe University of Tokyo

Principal Investigator

NAGAMUNE Teruyuki  The University of Tokyo, 大学院・工学系研究科, 教授 (20124373)

Co-Investigator(Kenkyū-buntansha) 新海 政重  東京大学, 大学院・工学系研究科, 講師 (70262889)
河原 正浩  東京大学, 大学院・工学系研究科, 助教 (50345097)
山口 哲志  東京大学, 大学院・工学系研究科, 助教 (80398106)
Co-Investigator(Renkei-kenkyūsha) KAWAHARA Masahiro  東京大学, 大学院・工学系研究科, 講師 (50345097)
YAMAGUCHI Satoshi  東京大学, 大学院・工学系研究科, 助教 (80398106)
Project Period (FY) 2006 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥49,660,000 (Direct Cost: ¥38,200,000、Indirect Cost: ¥11,460,000)
Fiscal Year 2009: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
Fiscal Year 2008: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
Fiscal Year 2007: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000)
Fiscal Year 2006: ¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Keywords抗体 / 受容体 / 造血前駆細胞 / 増殖制御 / シグナル伝達 / がん治療 / 樹状前駆細胞 / ガン治療
Research Abstract

Since dendritic cells are potent antigen-presenting cells that can efficiently activate antigen-specific cytotoxic T cells, they are promising for application to cancer therapy. However, the method to efficiently expand dendritic cells has remained to be established. In this study, an artificial cytokine receptor recognizing antigen quite different from natural cytokines or growth factors was expressed in a hematopoietic stem cell, which is a source of dendritic cells. Consequently, we successfully demonstrated the expansion of hematopoietic stem cells via antigen-induced activation of the artificial cytokine receptor.

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report   Self-evaluation Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (89 results)

All 2010 2009 2008 2007 2006 Other

All Journal Article (32 results) (of which Peer Reviewed: 26 results) Presentation (46 results) Book (10 results) Remarks (1 results)

  • [Journal Article] Engineering cytokine receptors to control cellular functions2010

    • Author(s)
      Kawahara, M., Ueda, H., Nagamune, T.
    • Journal Title

      Biochem.Eng.J. 48

      Pages: 283-294

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] T cell growth control using hapten-specific antibody/interleukin-2 receptor chimera2009

    • Author(s)
      Sogo, T., Kawahara, M., Ueda, H., Otsu, M., Onodera, M., Nakauchi, H., Nagamune, T.
    • Journal Title

      Cytokine 46

      Pages: 127-136

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The influence of domain structures on the signal transduction of chimeric receptors derived from the erythropoietin receptor2009

    • Author(s)
      Liu, W., Kawahara, M., Ueda, H., Nagamune, T.
    • Journal Title

      J.Biochem. 145

      Pages: 575-584

    • NAID

      10025588765

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Selection and growth regulation of genetically modified cells with hapten-specific antibody/receptor tyrosine kinase chimera2009

    • Author(s)
      Tanaka, K., Kawahara, M., Ueda, H., Nagamune, T.
    • Journal Title

      Biotechnol.Prog. 25

      Pages: 1138-1145

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] T cell growth control using hapten-specific antibody/interleukin-2 receptor chimera2009

    • Author(s)
      Sogo, T., et al
    • Journal Title

      Cytokine 46

      Pages: 127-136

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The influence of domain structures on the signal transduction of chimeric receptors derived from the erythropoietin receptor2009

    • Author(s)
      Liu, W., et al.
    • Journal Title

      J.Biochem. 145

      Pages: 575-584

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Selection and growth regulation of genetically modified cells with hapten-specific antibody/receptor tyrosine kinase chimera2009

    • Author(s)
      Tanaka, K., et al.
    • Journal Title

      Biotechnol.Prog. 25

      Pages: 1138-1145

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] T cell growth control using hapten-specific antibody/interleukin-2 receptor chimera2009

    • Author(s)
      Sogo, T., Kawahara, M., Ueda, H., Otsu, M., Onodera, M., Nakauchi, H. and Nagamune, T
    • Journal Title

      Cytokine 46

      Pages: 127-136

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] The influence of domain structures on the signal transduction of chimeric receptors derived from the erythropoietin receptor2009

    • Author(s)
      Liu, W., Kawahara, M., Ueda, H.and Nagamune, T
    • Journal Title

      J. Biochem doi : 10.1093/jb/mvp013

    • NAID

      10025588765

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] T cell growth control using hapten-specific antibody/interleukin-2 receptor chimera2009

    • Author(s)
      Sogo, T, et al
    • Journal Title

      Cytokine 46

      Pages: 127-136

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Construction of a fluorescein-responsive chimeric receptor with strict ligand dependency2008

    • Author(s)
      Liu, W., Kawahara, M., Ueda, H., Nagamune, T.
    • Journal Title

      Biotechnol.Bioeng. 101

      Pages: 975-984

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Selective expansion of genetically modified T cells using an antibody/interleukin-2 receptor chimera2008

    • Author(s)
      Sogo, T., Kawahara, M., Tsumoto, K., Kumagai, I., Ueda, H., Nagamune, T.
    • Journal Title

      J.Immunol.Methods 337

      Pages: 16-23

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Antigen-mediated migration of murine pro-B Ba/F3 cells via an antibody/receptor chimera2008

    • Author(s)
      Kawahara, M., Shimo, Y., Sogo, T., Hitomi, A., Ueda, H., Nagamune, T.
    • Journal Title

      J.Biotechnol. 133

      Pages: 154-161

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Selective expansion of genetically modified T cells using an antibody/interleukin-2 receptor chimera2008

    • Author(s)
      Sogo, T., Kawahara, M., Tsumoto, K., Kumagai, I., Ueda, H.and Nagamune, T.
    • Journal Title

      J. Immunol. Methods 337

      Pages: 16-23

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Construction of a fluorescein-responsive chimeric receptor with strict ligand dependency2008

    • Author(s)
      Liu, W., Kawahara, M., Ueda, H.and Nagamune, T.
    • Journal Title

      Biotechnol. Bioeng 101

      Pages: 975-984

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Selective expansion of genetically modified T cells using an antibody/interleukin-2 receptor chimera2008

    • Author(s)
      Sogo, T, et al.
    • Journal Title

      J. lmmunol,Methods 337

      Pages: 16-23

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Construction of a fluorescein-responsive chimeric receptor with strict ligand dependency2008

    • Author(s)
      Liu, W, et al
    • Journal Title

      Biotechnol.Bioeng. 101

      Pages: 975-984

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antigen-mediated migration of murine pro-B Ba/F3 cells via an antibody/receptor chimera2008

    • Author(s)
      Kawahara, M, et al
    • Journal Title

      J. Biotechnol. 133

      Pages: 154-161

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Construction of a fluorescein-responsive chimeric receptor with strict ligand dependency2008

    • Author(s)
      Liu, W., et. al.
    • Journal Title

      Biotechnol.Bioeng. 101(in press)(掲載確定)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antigen-mediated migration of murine pro-B Ba/F3 cells via an antibody/receptor chimera.2008

    • Author(s)
      Kawahara, M., et. al.
    • Journal Title

      J.Biotechnol. 133

      Pages: 154-161

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mimicry of erythropoietin and interleukin-6 signaling by an antibody/cytokine receptor chimera in murine myeloid 32D cells2007

    • Author(s)
      Kawahara M., Ueda, H., Tsumoto, K., Kumagai, I., Nagamune, T.
    • Journal Title

      J.Biochem. 141

      Pages: 563-571

    • NAID

      10020100276

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Antigen-mediated growth control of hybridoma cells via a human artificial chromosome2007

    • Author(s)
      Kawahara, M., Inoue, T., Ren, X., Sogo, T., Yamada, H., Katoh, M., Ueda, H., Oshimura, M., Nagamune, T.
    • Journal Title

      Biochim.Biophys.Acta 1770

      Pages: 206-212

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mimicry of erythropoietin and interleukin-6 signaling by an antibody/cytokine receptor chimera in murine myeloid 32D cells2007

    • Author(s)
      Kawahara, M., et. al.
    • Journal Title

      J.Biochem 141

      Pages: 563-571

    • NAID

      10020100276

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 膜タンパク質の改変による細胞応答の制御2007

    • Author(s)
      河原 正浩, ら
    • Journal Title

      高分子 56

      Pages: 828-830

    • NAID

      10019959391

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Mimicry of erythropoietin and interleukin-6 signaling by an antibody/cytokine receptor chimera in murine myeloid 32D cells2007

    • Author(s)
      Kawahara, M. et al.
    • Journal Title

      J.Biochem. 143

      Pages: 563-571

    • NAID

      10020100276

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Antigen-mediated growth control of hybridoma cells via a human artificial chromosome2007

    • Author(s)
      Kawahara, M. et al.
    • Journal Title

      Biochim.Biophys.Acta 1770

      Pages: 206-212

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Growth control of hybridoma cells with an artificially induced EpoR-gp130 heterodimer2006

    • Author(s)
      Kawahara, M., Ogo, Y., Tsumoto, K., Kumagai, I., Ueda, H., Nagamune, T.
    • Journal Title

      Cytotechnology 52

      Pages: 171-179

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Exogenous gene expression and growth regulation of hematopoietic cells via a novel human artificial chromosome2006

    • Author(s)
      Yamada, H., Kunisato, A., Kawahara, M., Tahimic, C. G. T., Ren, X., Ueda, H., Nagamune, T., Katoh, M., Inoue, T., Nishikawa, M., Oshimura, M.
    • Journal Title

      J.Hum.Genet. 51

      Pages: 147-150

    • NAID

      10017329275

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Exogenous gene expression and growth regulation of hematopoietic cells via a novel human artificial chromosome2006

    • Author(s)
      Yamada, H. et al.
    • Journal Title

      J.Hum.Genet. 51

      Pages: 147-150

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 細胞表面受容体工学の最近の進歩2006

    • Author(s)
      上田宏ら
    • Journal Title

      バイオインダストリー 64(2)

      Pages: 18-23

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Selection and growth regulation of genetically modified cells withhapten-specific antibody/receptor tyrosine kinase chimera

    • Author(s)
      Tanaka, K., Kawahara, M., Ueda, H.and Nagamune, T
    • Journal Title

      Biotechnol. Prog (in press)

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Growth control of hybridoma cells with an artificially induced EpoR-gp130 heterodimer

    • Author(s)
      Kawahara, M. et al.
    • Journal Title

      Cytotechnology (in press)

    • Related Report
      2006 Annual Research Report
  • [Presentation] フルオレセイン応答性キメラ受容体を用いたT細胞の増殖制御2010

    • Author(s)
      十河孝浩, 河原正浩, 上田宏, 大津真, 小野寺雅史, 中内啓光, 長棟輝行
    • Organizer
      化学工学会第75年会
    • Place of Presentation
      鹿児島大学
    • Year and Date
      2010-03-19
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] Fluorescein-responsive migration of mammalian cells equipped with an antibody/receptor chimera2009

    • Author(s)
      Masahiro Kawahara, Yusuke Shimo, Azusa Hitomi, Yuki Mochida, Takahiro Sogo, Hiroshi Ueda, Teruyuki Nagamune
    • Organizer
      APBioChEC'09
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2009-11-26
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] Growth promotion of mouse T cells using a fluorescein-responsive chimeric interleukin-2 receptor2009

    • Author(s)
      Takahiro Sogo, Masahiro Kawahara, Hiroshi Ueda, Makoto Otsu, Masafumi Onodera, Hiromitsu Nakauchi, Teruyuki Nagamune
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2009-10-24
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 抗体/受容体キメラを用いた細胞運動制御2009

    • Author(s)
      河原正浩, 下茂佑輔, 人見梓, 持田祐希, 十河孝浩, 上田宏, 長棟輝行
    • Organizer
      第61回日本生物工学会大会
    • Place of Presentation
      名古屋大学東山キャンパス
    • Year and Date
      2009-09-24
    • Related Report
      2009 Final Research Report
  • [Presentation] 抗体/受容体キメラを用いた細胞運動制御2009

    • Author(s)
      河原正浩, ら
    • Organizer
      第61回日本生物工学会大会
    • Place of Presentation
      名古屋大学
    • Year and Date
      2009-09-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] 抗体-エリスロポエチン受容体キメラのシグナル伝達におけるドメイン構造の影響2009

    • Author(s)
      劉文海, ら
    • Organizer
      化学工学会第41回秋季大会
    • Place of Presentation
      広島大学
    • Year and Date
      2009-09-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] 抗体-サイトカイン受容体キメラによる遺伝子導入造血幹細胞の増幅法2009

    • Author(s)
      陳建宏, 十河孝浩, 河原正浩, 上田宏, 大津真, 小野寺雅史, 中内啓光, 長棟輝行
    • Organizer
      化学工学会第41回秋季大会
    • Place of Presentation
      広島大学東広島キャンパス
    • Year and Date
      2009-09-17
    • Related Report
      2009 Final Research Report
  • [Presentation] 抗体-サイトカイン受容体キメラによる遺伝子導入造血幹細胞の増幅法2009

    • Author(s)
      陳建宏, ら
    • Organizer
      化学工学会第41回秋季大会
    • Place of Presentation
      広島大学
    • Year and Date
      2009-09-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] 樹状細胞による抗体アンカーリング癌細胞の貧食と癌細胞特異的免疫の活性化2009

    • Author(s)
      富田麗, 山口哲志, 長棟輝行
    • Organizer
      化学工学会第41回秋季大会
    • Place of Presentation
      広島大学東広島キャンパス
    • Year and Date
      2009-09-16
    • Related Report
      2009 Final Research Report
  • [Presentation] ジスルフィド特異的PEG脂質化抗体のDC免疫療法への応用2009

    • Author(s)
      富田麗, 山口哲志, 長棟輝行
    • Organizer
      第24回生体機能関連化学シンポジウム, 第12回バイオテクノロジー部会シンポジウム
    • Place of Presentation
      九州大学医学部キャンパス百年講堂
    • Year and Date
      2009-09-13
    • Related Report
      2009 Final Research Report
  • [Presentation] キメラ受容体と遺伝子組換え酵素を用いた抗体選択・生産一貫系の基礎的検討2009

    • Author(s)
      林隼, ら
    • Organizer
      日本動物細胞工学会2009年度大会(JAACT 2009)
    • Place of Presentation
      つくば国際会議場
    • Year and Date
      2009-07-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] 厳格なフルオレセイン応答性を持つキメラ受容体の構築2009

    • Author(s)
      劉文海, 河原正浩, 上田宏, 長棟輝行
    • Organizer
      化学工学会第74年会
    • Place of Presentation
      横浜国立大学
    • Year and Date
      2009-03-18
    • Related Report
      2009 Final Research Report
  • [Presentation] Controlling cell migration with an artificial ligand2008

    • Author(s)
      Masahiro Kawahara, Yusuke Shimo, Azusa Hitomi, Takahiro Sogo, Hiroshi Ueda, Teruyuki Nagamune
    • Organizer
      BMB2008 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2008-12-11
    • Related Report
      2009 Final Research Report
  • [Presentation] Antigen-dependent migration of mammalian cells via an antibody/receptor chimera2008

    • Author(s)
      Masahiro Kawahara, Yusuke Shimo, Azusa Hitomi, Takahiro Sogo, Hiroshi Ueda, Teruyuki Nagamune
    • Organizer
      The 14th Symposium of Young Asian Biochemical Engineers' Community
    • Place of Presentation
      芝浦工業大学豊洲キャンパス
    • Year and Date
      2008-11-30
    • Related Report
      2009 Final Research Report 2008 Self-evaluation Report
  • [Presentation] THE CHARACTERISTIC OF CHIMERIC RECEPTORS BASED ON ERYTHROPOIETIN RECEPTOR2008

    • Author(s)
      Wenhai Liu, Masahiro Kawahara, Hiroshi Ueda, Teruyuki Nagamune
    • Organizer
      The 21st Annual and International Meeting of the Japanese Association for Animal Cell Technology (JAACT2008)
    • Place of Presentation
      Fukuoka, Japan
    • Year and Date
      2008-11-26
    • Related Report
      2009 Final Research Report 2008 Self-evaluation Report
  • [Presentation] GROWTH CONTROL OF MAMMALIAN CELLS VIA A HUMAN ARTIFICIAL CHROMOSOME HARBORING A CHIMERIC RECEPTOR2008

    • Author(s)
      Masahiro Kawahara, Toshiaki Inoue, Xianying Ren, Takahiro Sogo, Hidetoshi Yamada, Motonobu Katoh, Hiroshi Ueda, Mitsuo Oshimura, Teruyuki Nagamune
    • Organizer
      The 21st Annual and International Meeting of the Japanese Association for Animal Cell Technology (JAACT2008)
    • Place of Presentation
      Fukuoka, Japan
    • Year and Date
      2008-11-24
    • Related Report
      2009 Final Research Report
  • [Presentation] 人工染色体と抗体-受容体キメラを用いた動物細胞の増殖制御2008

    • Author(s)
      河原正浩, 井上敏昭, 任鮮英, 十河孝浩, 山田秀俊, 加藤基伸, 上田宏, 押村光雄, 長棟輝行
    • Organizer
      化学工学会第40回秋季大会
    • Place of Presentation
      東北大学
    • Year and Date
      2008-09-24
    • Related Report
      2009 Final Research Report
  • [Presentation] 抗原応答性キメラ受容体を用いた細胞の運動制御2008

    • Author(s)
      人見梓, 下茂佑輔, 十河孝浩, 河原正浩, 上田宏, 長棟輝行
    • Organizer
      化学工学会第73年会
    • Place of Presentation
      静岡大学浜松キャンパス
    • Year and Date
      2008-03-17
    • Related Report
      2009 Final Research Report
  • [Presentation] 細胞膜修飾剤を用いた細胞治療技術の開発2008

    • Author(s)
      長棟輝行
    • Organizer
      先端医療開発研究シンポジウム
    • Place of Presentation
      東京大学安田講堂
    • Year and Date
      2008-01-22
    • Related Report
      2009 Final Research Report
  • [Presentation] The characteristic of chimeric receptors based on erythropoietin receptor2008

    • Author(s)
      Liu, W, et al
    • Organizer
      The 21st Annual and International Meeting of Japanese Association for Animal Cell Technology(JAACT 2008)
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2008 Annual Research Report
  • [Presentation] Growth control of mammalian cells via a human artificial chromosome harboring a chimeric receptor2008

    • Author(s)
      Kawahara, M, et al
    • Organizer
      The 21st Annual and International Meeting of Japanese Association for Animal Cell Technology(JAACT 2008)
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2008 Annual Research Report
  • [Presentation] Antigen-dependent migration of mammalian cells via an antibody/receptor chimera2008

    • Author(s)
      Kawahara, M, et al
    • Organizer
      The 14th Symposium of Young Asian Biochemical En gineers' Community(YABEC2008)
    • Place of Presentation
      芝浦工業大学豊洲キャンパス
    • Related Report
      2008 Annual Research Report
  • [Presentation] Controlling cell migration with artificial ligand2008

    • Author(s)
      Kawahara, M, et al
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会合同大会(BMB2008)
    • Place of Presentation
      神戸国際会議場
    • Related Report
      2008 Annual Research Report
  • [Presentation] 人工染色体と抗体一受容体キメラを用.いた動物細胞の増殖制御2008

    • Author(s)
      河原 正浩ら
    • Organizer
      化学工学会第40回秋季大会
    • Place of Presentation
      東北大学川内北キャンパス
    • Related Report
      2008 Annual Research Report
  • [Presentation] 厳格なフルオレセイン応答性を持つキメラ受容体の構築2008

    • Author(s)
      河原 正浩ら
    • Organizer
      化学工学会第74年会
    • Place of Presentation
      横浜国立大学
    • Related Report
      2008 Annual Research Report
  • [Presentation] 抗体/受容体キメラによる遺伝子導入造血幹細胞の増殖制御2008

    • Author(s)
      陳 建宏, ら
    • Organizer
      化学工学会第73年会
    • Place of Presentation
      静岡大学浜松キャンパス
    • Related Report
      2007 Annual Research Report
  • [Presentation] 抗原応答性キメラ受容体を用いた細胞の運動性制御2008

    • Author(s)
      人見 梓, ら
    • Organizer
      化学工学会第73年会
    • Place of Presentation
      静岡大学浜松キャンパス
    • Related Report
      2007 Annual Research Report
  • [Presentation] The Influence of Domain and Conformation Change to the Signal Transduction of Chimeric Receptors Based on Erythropoietin Receptor2007

    • Author(s)
      Wenhai Liu, Masahiro Kawahara, Hiroshi Ueda, Teruyuki Nagamune
    • Organizer
      第30回日本分子生物学会年会第80回日本生化学会大会合同大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-12-11
    • Related Report
      2009 Final Research Report
  • [Presentation] The Cell Surface Engineering for Biotechnology and Cancer Therapy2007

    • Author(s)
      Nagamune, T.
    • Organizer
      APBioChEC'07, Asia Pacific Biochemical Engineering Conference
    • Place of Presentation
      Taipei International Convention Center, Taipei, Taiwan
    • Year and Date
      2007-11-07
    • Related Report
      2009 Final Research Report
  • [Presentation] THE INFLUENCE OF DOMAIN AND CONFORMATION CHANGE TO THE SIGNAL TRANSDUCTION OF CHIMERIC RECEPTORS BASED ON ERYTHROPOIETIN RECEPTOR2007

    • Author(s)
      Wenhai Liu, Masahiro Kawahara, Hiroshi Ueda, Teruyuki Nagamune
    • Organizer
      The 13th Symposium of Young Asian Biochemical Engineers' Community (YABEC 2007)
    • Place of Presentation
      Korea University, Seoul, Korea
    • Year and Date
      2007-10-21
    • Related Report
      2009 Final Research Report
  • [Presentation] キメラ受容体を用いた抗体scFv選択・生産一貫システムの開発2007

    • Author(s)
      林隼, 田中健人, 河原正浩, 上田宏, 長棟輝行
    • Organizer
      第59回日本生物工学会 (2007)
    • Place of Presentation
      広島大学東広島キャンパス
    • Year and Date
      2007-09-27
    • Related Report
      2009 Final Research Report
  • [Presentation] 人工染色体を用いたキメラ受容体による造血幹細胞の増殖制御2007

    • Author(s)
      陳建宏, 河原正浩, 上田宏, 長棟輝行
    • Organizer
      第59回日本生物工学会 (2007)
    • Place of Presentation
      広島大学東広島キャンパス
    • Year and Date
      2007-09-26
    • Related Report
      2009 Final Research Report
  • [Presentation] 人工染色体を用いたキメラ受容体による造血幹細胞の増殖制御2007

    • Author(s)
      陳建宏,河原正浩,上田宏,長棟輝行
    • Organizer
      第59回日本生物工学会(2007)
    • Place of Presentation
      広島大学東広島キャンパス
    • Year and Date
      2007-09-26
    • Related Report
      2008 Self-evaluation Report
  • [Presentation] キメラIL-2レセプター導入による遺伝子導入T細胞の選択的増幅法の開発2007

    • Author(s)
      十河孝浩, 河原正浩, 上田宏, 長棟輝行
    • Organizer
      第59回日本生物工学会 (2007)
    • Place of Presentation
      広島大学東広島キャンパス
    • Year and Date
      2007-09-25
    • Related Report
      2009 Final Research Report
  • [Presentation] キメラIL-2レセプター導入による遺伝子導入T \細胞の選択的増幅法の開発2007

    • Author(s)
      十河孝浩、河原正浩、上田宏、長棟輝行
    • Organizer
      第59 \回日本生物工学会(2007)
    • Place of Presentation
      広島大学東広島キャンパス
    • Year and Date
      2007-09-25
    • Related Report
      2008 Self-evaluation Report
  • [Presentation] がん治療を目指したキメラIL-2R導入T細胞の選択的増幅法の開発2007

    • Author(s)
      十河孝浩, 河原正浩, 上田宏, 長棟輝行
    • Organizer
      化学工学会第38回秋季大会
    • Place of Presentation
      福岡大学
    • Year and Date
      2007-09-17
    • Related Report
      2009 Final Research Report
  • [Presentation] キメラ受容体による非血球細胞の増殖促進法2007

    • Author(s)
      田中健人, 河原正浩, 上田宏, 長棟輝行
    • Organizer
      化学工学会第38回秋季大会
    • Place of Presentation
      福岡大学
    • Year and Date
      2007-09-17
    • Related Report
      2009 Final Research Report
  • [Presentation] THE INFLUENCE OF DOMAIN AND CONFORMATION CHANGE TO THE SIGNAL TRANSDUCTION OF CHIMERIC RECEPTORS BASED ON ERYTHROPOIETIN RECEPTOR2007

    • Author(s)
      Wenhai Liu, Masahiro Kawahara, Hiroshi Ueda, Teruyuki Nagamune
    • Organizer
      The 2nd International Workshop on Approaches to Single-Cell Analysis
    • Place of Presentation
      Waseda Universigy, Tokyo, Japan
    • Year and Date
      2007-09-06
    • Related Report
      2009 Final Research Report
  • [Presentation] キメラ受容体を用いた抗体scFv選択・一貫システムの開発2007

    • Author(s)
      林 隼ら
    • Organizer
      第59回日本生物工学会大会
    • Place of Presentation
      広島大学
    • Related Report
      2007 Annual Research Report
  • [Presentation] キメラ-2レセプター導入による遺伝子遺入T細胞の選択的増幅法の開発2007

    • Author(s)
      十河 孝浩, ら
    • Organizer
      日本生物工学会第59回大会
    • Place of Presentation
      広島大学
    • Related Report
      2007 Annual Research Report
  • [Presentation] The Signal transduction of Chimeric Receptors Based on Eruthropoietin Receptor2007

    • Author(s)
      Liu, W., et. al.
    • Organizer
      The 2nd International Workshop on Approaches to Singie-Cell Analysis
    • Place of Presentation
      早稲田大学
    • Related Report
      2007 Annual Research Report
  • [Presentation] The Influence of Domain and Conformation Change to the Signal Transduction of Chlmeric Receptors Based on Erythropoietin Receptor2007

    • Author(s)
      Liu, W., et. al.
    • Organizer
      The 13th Symposium of Young Asian Biochemical Engineers'Community
    • Place of Presentation
      Korea University(Seou1)
    • Related Report
      2007 Annual Research Report
  • [Presentation] 人工染色体を用いたキメラ受容体による造血幹細胞の増殖制御2007

    • Author(s)
      陳 建宏, ら
    • Organizer
      日本生物工学会第59回大会
    • Place of Presentation
      広島大学
    • Related Report
      2007 Annual Research Report
  • [Presentation] キメラIL-2Rを用いた遺伝子導入T細胞の選択的増幅法の開発2006

    • Author(s)
      十河孝浩, 河原正浩, 上田宏, 長棟輝行
    • Organizer
      化学工学会室蘭大会
    • Place of Presentation
      室蘭工大
    • Year and Date
      2006-08-24
    • Related Report
      2009 Final Research Report
  • [Presentation] キメラ受容体による細胞増殖促進法の開発2006

    • Author(s)
      田中健人・河原正浩・上田宏・長棟輝行
    • Organizer
      化学工学会室蘭大会
    • Place of Presentation
      室蘭工大
    • Year and Date
      2006-08-24
    • Related Report
      2009 Final Research Report
  • [Presentation] Selective expansion of genetically modified T cells using a chimeric IL-2 receptor for cancer therapy2006

    • Author(s)
      Takahiro Sogo, Masahiro Kawahara, Hiroshi Ueda, Teruyuki Nagamune
    • Organizer
      The 19th International and Annual Meeting of Japanese Association for Animal Cell Technology (JAACT2006)
    • Place of Presentation
      ぱるるプラザ京都
    • Related Report
      2009 Final Research Report
  • [Book] Animal Cell Technology : Basic & Applied Aspects (Ikura, K. et al., Ed.), 15, (Construction of a fluorescein-responsive chimeric receptor with strict ligand dependency and analysis of the role of erythropoietin receptor domains in signal transduction)2009

    • Author(s)
      Liu, W., Kawahara, M., Ueda, H., Nagamune, T.
    • Publisher
      Springer
    • Related Report
      2009 Final Research Report
  • [Book] Animal Cell Technology : Basic & Applied Aspects (Ikura, K. et al., Ed.), 15, (Promoting non-hematopoietic cell proliferation by chimeric receptors)2009

    • Author(s)
      Tanaka, K., Kawahara, M., Ueda, H., Nagamune, T.
    • Publisher
      Springer
    • Related Report
      2009 Final Research Report
  • [Book] Animal Cell Technology : Basic & Applied Aspects (Ikura, K. et al., Ed.), 15, Selective expansion of genetically modified T cells using a chimeric IL-2 receptor for cancer therapy2009

    • Author(s)
      Sogo, T., Kawahara, M., Ueda, H., Nagamune, T.
    • Publisher
      Springer
    • Related Report
      2009 Final Research Report
  • [Book] 細胞表面に人工分子を導入し、腫瘍免疫療法の効果向上をめざす(メディカルバイオ)2008

    • Author(s)
      長棟輝行
    • Publisher
      オーム社
    • Related Report
      2009 Final Research Report
  • [Book] 膜タンパク質の改変による細胞応答の制御(高分子)2007

    • Author(s)
      河原正浩, 十河孝浩, 上田宏, 長棟輝行
    • Related Report
      2009 Final Research Report
  • [Book] 動物細胞での抗体選択・生産一貫システムの開発抗依医薬の最前線2007

    • Author(s)
      河原正浩, 上田宏, 長棟輝行
    • Publisher
      CMC出版
    • Related Report
      2009 Final Research Report
  • [Book] 抗体医薬の最前線2007

    • Author(s)
      河原 正浩, ら
    • Total Pages
      9
    • Publisher
      CMC出版
    • Related Report
      2007 Annual Research Report
  • [Book] 細胞表面受容体工学の最近の進歩(バイオサイエンスとインダストリー)2006

    • Author(s)
      上田宏, 河原正浩, 長棟輝行
    • Related Report
      2009 Final Research Report
  • [Book] Animal Cell Technology : Basic & Applied Aspects (Ikura, K. et.al., Ed.)

    • Author(s)
      Sogo, T., Kawahara, M., Ueda, H., and Nagamune, T.
    • Publisher
      Selective expansion of genetically modified T cells using a chimeric IL-2 receptor for cancer therapy(in press)
    • Related Report
      2008 Self-evaluation Report
  • [Book] 抗体医薬の最前線

    • Author(s)
      河原正浩ら
    • Publisher
      CMC出版 (in press)
    • Related Report
      2006 Annual Research Report
  • [Remarks]

    • URL

      http://park.itc.u-tokyo.ac.jp/nagamune/index.html

    • Related Report
      2008 Self-evaluation Report

URL: 

Published: 2006-04-01   Modified: 2016-04-21  

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