Integrated studies on signaling and physiological function of green tea catechin through the catechin receptor

• Project/Area Number: 18208012
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Food science
• Research Institution: Kyushu University
• Principal Investigator: TACHIBANA Hirofumi Kyushu University, 大学院・農学研究院, 准教授 (70236545)
• Co-Investigator(Kenkyū-buntansha): FUJIMURA Yoshinori 九州大学, 先端融合医療レドックスナビ研究拠点, 准教授 (20390304)
• Project Period (FY): 2006 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥43,420,000 (Direct Cost: ¥33,400,000、Indirect Cost: ¥10,020,000); Fiscal Year 2009: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000); Fiscal Year 2008: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000); Fiscal Year 2007: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000); Fiscal Year 2006: ¥13,000,000 (Direct Cost: ¥10,000,000、Indirect Cost: ¥3,000,000)
• Keywords: EGCG / 緑茶 / 受容体 / シグナリング / 67LR / カテキン / 機能性 / 炎症制御 / TLR4 / Tollip / 感知遺伝子 / マクロファージ / ATRA / がん予防 / 分子標的 / MYPT1 / 感受性 / がん予坊 / eEF1a / シグナル / がん

Research Abstract

67-kDa laminin receptor (67LR) has been identified as a cell surface receptor for green tea polyphenol (-)-epigallocatechin-3-gallate(EGCG)that mediates the anticancer activity of EGCG. Eukaryotic translation elongation factor 1A (eEF1A) and myosin phosphatase targeting subunit 1(MYPT1) have been identified as components responsible for the anticancer activity of EGCG in vivo. We identified functional motif on the extracellular domain of 67LR for exerting EGCG action. We also found that 67LR mediates anti-allergic and anti-inflammatory activities of EGCG, and clarified the molecular basis for the EGCG action though the receptor.

Research Products

• [Journal Article] Antihypertensive effect of Benifuuki tea containing O-methylated EGCG. (2010)
  • Author(s): Kurita, I., et.al.
  • Journal Title: J. Agric. Food Chem. 58 Pages: 1903-1908
  • Peer Reviewed
• [Journal Article] Flavones suppress type I IL 4 receptor signalinig by down regulating the expression of common gamma chain. (2010)
  • Author(s): Yamashita, S., et al.
  • Journal Title: FEBS Lett. 584 Pages: 775-779
  • Peer Reviewed
• [Journal Article] Highly sensitive MALDI Mass spectrometry for high throughput metabolic profiling (2010)
  • Author(s): Miura, D., et al.
  • Journal Title: Anal. Chem. 82 Pages: 498-504
  • Peer Reviewed
• [Journal Article] 緑茶カテキンの機能性を享受するための遺伝子 (2010)
  • Author(s): 立花宏文
  • Journal Title: 月刊フードリサーチ 643 Pages: 28-31
• [Journal Article] Modulation of Proliferation and differentiation of C2Cl2 skeletal muscle cells by fatty acids. (2009)
  • Author(s): Lee, J.H.
  • Journal Title: Life Sci. 84 Pages: 415-420
  • Peer Reviewed
• [Journal Article] 植物性食品成分の生体応答の分子機構 (2009)
  • Author(s): 藤村由紀、立花宏文
  • Journal Title: 化学と生物 47 Pages: 111-117
  • NAID: 10026434778
• [Journal Article] 緑茶カテキンの受容体とシグナリング (2009)
  • Author(s): 立花宏文
  • Journal Title: 生化学 81 Pages: 290-294
  • NAID: 10024916433
• [Journal Article] 脂溶性食品成分フラボン類の抗アレルギー作用 (2009)
  • Author(s): 山下修矢, ら
  • Journal Title: オレオサイエンス 9 Pages: 337-344
• [Journal Article] Green tea polyphenol epigallocatechin-3-gallate signaling pathway through 67-kDa laminin receptor (2008)
  • Author(s): Umeda, D., Yano, S., Yamada, K., Tachibana, H.
  • Journal Title: J. Biol. Chem. 283 Pages: 3050-3058
  • Peer Reviewed
• [Journal Article] The impact of the 67 kDa laminin receptor on both cell-surface binding and anti-allergic action of tea catechins (2008)
  • Author(s): Fujimura, Y., Umeda, D., Yamada, K., Tachibana, H
  • Journal Title: Arch. Biochem. Biophys 476 Pages: 133-138
  • Peer Reviewed
• [Journal Article] The impact of the 67 kDa laminin receptor on both cell-surface binding and anti-allergic action of tea catechins (2008)
  • Author(s): Fujimura, Y., Umeda, D., Yamada, K., Tachibana, H
  • Journal Title: Arch. Biochem. Biophys. 476 Pages: 133-138
  • Peer Reviewed
• [Journal Article] The impact of the 67 kDa laminin receptor on both cell-surface binding and anti-allergic action of tea catechins (2008)
  • Author(s): Fujimura, Y, et al.
  • Journal Title: Arch. Biochem. Biophys 476 Pages: 133-138
  • Peer Reviewed
• [Journal Article] Involvement of 67-kDa laminin receptor-mediated myosin phosphatase activation in antiproliferative effect of epigall ocatechin-3-0-gallate at a physiological concentration on Caco-2 colon cancer cells (2008)
  • Author(s): Umeda, D., et al.
  • Journal Title: Biochem. Biophys. Res. Commun 371 Pages: 172-176
  • Peer Reviewed
• [Journal Article] H89 (N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide) induces reduction of myosin regulatory light chain phosphorylation and inhibits cell proliferation (2008)
  • Author(s): Umeda, D, et al.
  • Journal Title: Eur. J. Pharm. 590 Pages: 61-66
  • Peer Reviewed
• [Journal Article] Identification of eukaryotic translation elongation factor 1A as_a downstream mediator of EGCG signaling through 67-kDa laminin receptor. (2008)
  • Author(s): Umeda, D, et al.
  • Journal Title: J. Clin. Biochem. Nutr. 43 Pages: 113-116
  • Peer Reviewed
• [Journal Article] Relationship between the suppressive effect of methylated derivatives of EGCG on FcεRI Expression and their cell surface binding activities. (2008)
  • Author(s): Yano, S, et al.
  • Journal Title: J. Clin. Biochem. Nutr. 43 Pages: 473-476
  • Peer Reviewed
• [Journal Article] The 67 kDa laminin receptor mediates anti -allergic effects of epigallocatechin-3-0-(3-0-methy1) gallate. (2008)
  • Author(s): Fujimura, Y., et al.
  • Journal Title: J. Clin. Biochem. Nutr. 43 Pages: 477-480
  • Peer Reviewed
• [Journal Article] 「べにふうき」緑茶 (2008)
  • Author(s): 山本(前田)万里ら
  • Journal Title: 化学と生物 46 Pages: 214-216
• [Journal Article] 緑茶カテキン受容体67LRを介したカテキンの機能性発現機構 (2008)
  • Author(s): 立花宏文
  • Journal Title: 日本薬理学雑誌 132 Pages: 145-149
  • NAID: 10024383730
  • Peer Reviewed
• [Journal Article] メチル化カテキン含有「べにふうき」緑茶のアレルギー性鼻炎症状軽減効果 (2008)
  • Author(s): 山本(前田)万里ら
  • Journal Title: アレルギー・免疫 15 Pages: 60-67
• [Journal Article] Green tea polyphenol epigallocatechin-3-gallate signaling pathway through 67-kDa laminin receptor (2008)
  • Author(s): Umeda, D., et. al.
  • Journal Title: J.Biol.Chem., 283 Pages: 3050-3058
  • Peer Reviewed
• [Journal Article] The 67kDa laminin receptor as a primary determinant of anti-allergic effects of O-methylated EGCG (2007)
  • Author(s): Fujimura, Y., Umeda, D., Yano, S., Maeda-Yamamoto, M., Yamada, K., Tachibana, H.
  • Journal Title: Biochem. Biophys. Res. Commun. 364 Pages: 79-85
  • Peer Reviewed
• [Journal Article] Relationship between biological activities of methylated derivatives of EGCG and their cell surface binding activities (2007)
  • Author(s): Yano, S., et. al.
  • Journal Title: J.Agric.Food Chem. 55 Pages: 7144-7148
  • Peer Reviewed
• [Journal Article] The 67kDa laminin receptor as a primary determinant of anti-allergic effects of 0-methylated EGCG (2007)
  • Author(s): Fujimura, Y., et. al.
  • Journal Title: Biochem.Biophys.Res.Commun. 364 Pages: 79-85
  • Peer Reviewed
• [Journal Article] Involvement of 67 kDa laminin receptor on cellular uptake of green tea polyphenol epigallocatechin-3-0-gallate in Caco-2 cells (2007)
  • Author(s): Ohta, etal.
  • Journal Title: Animal Cell Technology : Basic ＆ Applied Aspects 15(In press)
• [Journal Article] The involvement of the 67 kDa laminin receptor-mediated modulation of cytoskeleton in the degranulation inhibition induced by epigallocatechin-3-0-gallate (2006)
  • Author(s): Fujimura, Y., Yamada, K., Tachibana, H.
  • Journal Title: Biochem. Biophys. Res. Commun. 348 Pages: 524-531
• [Journal Article] 植物ポリフェノールの抗アレルギー作用 (2006)
  • Author(s): 立花宏文
  • Journal Title: Food style 21 64・12 Pages: 44-46
• [Journal Article] 緑茶カテキン受容体を介したカテキンの抗がん、抗アレルギー作用 (2006)
  • Author(s): 梅田大介, 立花宏文
  • Journal Title: 農林水産技術研究ジャーナル 29・7 Pages: 24-28
• [Journal Article] 緑茶カテキン受容体の発見 (2006)
  • Author(s): 立花宏文
  • Journal Title: 科学と生物 44・7 Pages: 432-434
• [Journal Article] 緑茶カテキン受容体を介したカテキンの機能性発現 (2006)
  • Author(s): 立花宏文
  • Journal Title: バイオサイエンスとインダストリー 64・12 Pages: 680-682
  • NAID: 10020354838
• [Journal Article] TLR 4 signaling inhibitory pathway induced by green tea polyphenol epigallocatechin 3 gallate through 67-kDa laminin receptor
  • Author(s): Byun, E.H., Fujimura, Y., Yamada, K., Tachibana, H.
  • Journal Title: J. Immunol. (in press)
  • Peer Reviewed
• [Presentation] Molecular basis for anti inflammatory actions of dietary polyphenols (2010)
  • Author(s): Fujimura, Y, ら
  • Organizer: 日本農芸化学会大会シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2010-03-30
• [Presentation] 緑茶カテキン受容体67LRによるEGCGの二面性制御 (2010)
  • Author(s): 塚本俊太郎, ら
  • Organizer: 日本農芸化学会大会
  • Place of Presentation: 東京
  • Year and Date: 2010-03-29
• [Presentation] EGCGの脂質ラフト調節作用のFRET解析 (2010)
  • Author(s): 熊添基文, ら
  • Organizer: 日本農芸化学会大会
  • Place of Presentation: 東京
  • Year and Date: 2010-03-28
• [Presentation] 食品の機能性研究と応用展開 (2010)
  • Author(s): 立花宏文
  • Organizer: 九州イノベーション創出促進協議会農工連携分科会講演会
  • Place of Presentation: 宮崎市
  • Year and Date: 2010-01-19
• [Presentation] 植物ホリフェノールの免疫調節作用とその分子基盤 (2010)
  • Author(s): 立花宏文
  • Organizer: 日本食品免疫学会次世代シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2010-01-18
• [Presentation] フードケミカルバイオロジー : 機能性食品因子の生体応答分子機構からみえてくるもの (2010)
  • Author(s): 立花宏文
  • Organizer: 九州大学歯学部小児口腔医学セミナ
  • Place of Presentation: 福岡市
  • Year and Date: 2010-01-14
• [Presentation] 緑茶カテキン受容体67LRに対する抗体の作製 (2009)
  • Author(s): 前田理沙, ら
  • Organizer: 日本フードファクター学会
  • Place of Presentation: 神戸市
  • Year and Date: 2009-11-15
• [Presentation] 緑茶カテキンEGCGは67LRを介してヘプチドグリカン誘導性炎症応答を抑制する (2009)
  • Author(s): 大村敏規, ら
  • Organizer: 日本フードファクター学会
  • Place of Presentation: 神戸市
  • Year and Date: 2009-11-15
• [Presentation] 緑茶カテキン投与マウス尿のメタボリック・プロファイリング (2009)
  • Author(s): 藤村由紀, ら
  • Organizer: 日本農芸化学会関西・中四国・西日本支部、日本栄養食糧学会九州沖縄支部、日本食品科学工学会西日本支部合同大会
  • Place of Presentation: 沖縄市
  • Year and Date: 2009-10-31
• [Presentation] ATRAによる緑茶カテキン受容体67LRの発現調節を介したEGCGの機能性増強 (2009)
  • Author(s): 李珠恵, ら
  • Organizer: 日本農芸化学会関西・中四国・西日本支部、日本栄養食糧学会九州沖縄支部、日本食品科学工学会西日本支部合同大会
  • Place of Presentation: 沖縄市
  • Year and Date: 2009-10-31
• [Presentation] 低酸素環境による緑茶カテキンEGCGのがん細胞増殖抑制作用の消失 (2009)
  • Author(s): 塚本俊太郎, ら
  • Organizer: 日本農芸化学会関西・中四国・西日本支部、日本栄養食糧学会九州沖縄支部、日本食品科学工学会西日本支部合同大会
  • Place of Presentation: 沖縄市
  • Year and Date: 2009-10-31
• [Presentation] 緑茶カテキン受容体67LRを介したEGCGのアホトーシス誘導機構 (2009)
  • Author(s): 弘津圭祐, ら
  • Organizer: 日本農芸化学会関西・中四国・西日本支部、日本栄養食糧学会九州沖縄支部、日本食品科学工学会西日本支部合同大会
  • Place of Presentation: 沖縄市
  • Year and Date: 2009-10-31
• [Presentation] 食品成分の免疫調節作用とその分子基盤 (2009)
  • Author(s): 立花宏文
  • Organizer: 日本農芸化学会関西・中四国・西日本支部、日本栄養食糧学会九州沖縄支部、日本食品科学工学会西日本支部合同大会
  • Place of Presentation: 沖縄市
  • Year and Date: 2009-10-30
• [Presentation] 緑茶カテキンのケミカルバイオロジー (2009)
  • Author(s): 立花宏文
  • Organizer: 日本カテキン学会基調講演
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2009-09-09
• [Presentation] 緑茶カテキンのケミカルバイオロジー (2009)
  • Author(s): 立花宏文
  • Organizer: 日本カテキン学会基調講演
  • Place of Presentation: 名古屋市
  • Year and Date: 2009-09-09
• [Presentation] EGCGの細胞増殖促進作用 : EGF受容体の活性化と細胞内ROS産生の抑制 (2009)
  • Author(s): 塚本俊太郎, ら
  • Organizer: 日本カテキン学会
  • Place of Presentation: 名古屋市
  • Year and Date: 2009-09-09
• [Presentation] FRETプローブを用いたEGCGの脂質ラフト調節作用の解析 (2009)
  • Author(s): 熊添基文, ら
  • Organizer: 日本カテキン学会
  • Place of Presentation: 名古屋市
  • Year and Date: 2009-09-09
• [Presentation] 緑茶カテキン受容体67LRを介したEGCGのアホトーシス誘導機構 (2009)
  • Author(s): 弘津圭祐, ら
  • Organizer: 日本カテキン学会
  • Place of Presentation: 名古屋市
  • Year and Date: 2009-09-09
• [Presentation] MALDI-MSを用いた超高速メタボリック・プロファイリング-緑茶カテキンEGCGの抗酸化ストレス活性評価 (2009)
  • Author(s): 藤村由紀, ら
  • Organizer: 日本カテキン学会
  • Place of Presentation: 名古屋市
  • Year and Date: 2009-09-09
• [Presentation] Combinatorial Synthesis of a Methylated Epigallocatechin Gallate Library on Solid-Phase. (2009)
  • Author(s): Hiroshi Tanaka, ら
  • Organizer: 第25回内藤カンファレンス
  • Place of Presentation: 北海道
  • Year and Date: 2009-09-08
• [Presentation] メタボリック・プロファイリング法によるシスプラチン誘導性酸化ストレスに対する緑茶ボリフェノールの活性評価 (2009)
  • Author(s): 藤村由紀, ら
  • Organizer: 日本酸化ストレス学会
  • Place of Presentation: 福岡市
  • Year and Date: 2009-06-25
• [Presentation] 緑茶カテキン受容体67LRを介したEGCGによるTLR4シグナリングの阻害メカニズム (2009)
  • Author(s): 邊義〓, ら
  • Organizer: 日本食品免疫学会5周年記念大会
  • Place of Presentation: 東京
  • Year and Date: 2009-05-27
• [Presentation] 食品因子の機能性とその標的分子 (2009)
  • Author(s): 立花宏文
  • Organizer: 日本栄養・食糧学会大会
  • Place of Presentation: 長崎市
  • Year and Date: 2009-05-21
• [Presentation] プロシアニジンの機能性発現における緑茶カテキン受容体67LRの開与 (2009)
  • Author(s): 栗原佳奈, ら
  • Organizer: 日本栄養・食糧学会大会
  • Place of Presentation: 長崎市
  • Year and Date: 2009-05-21
• [Presentation] 緑茶カテキンの標的分子研究からみえてきたこと (2009)
  • Author(s): 立花宏文
  • Organizer: 日本農芸化学会大会シンポジウム
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2009-03-28
• [Presentation] ANTI-INFLAMMATORY ACTION OF EPIGALLOCATECHIN-3-GALLATE AT A PHYSIOLOGICAL CONCENTRATION THROUGH THE 67-KDA LAMININ RECEPTOR IN LIPOPOLYSACCHARIDE-STIMULATED RAW264.7 CELLS (2008)
  • Author(s): Byun E-H., et al.
  • Organizer: 日本動物細胞工学会国際大会
  • Place of Presentation: 福岡市
  • Year and Date: 2008-11-25
• [Presentation] THE DOWNREGULATION OF MAST CELL ACTIVATION THROUGH THE SUPPRESSION OF THE HIGH-AFFINITY IGE RECEPTOR EXPRESSION BY GREEN TEA CATECHIN EGCG (2008)
  • Author(s): Tachibana, H., et al.
  • Organizer: 日本動物細胞工学会国際大会
  • Place of Presentation: 福岡市
  • Year and Date: 2008-11-25
• [Presentation] 緑茶カテキンの逆作用 : 67LRの発現低下はEGCGのがん細胞増殖促進を誘導する (2008)
  • Author(s): 塚本俊太郎ら
  • Organizer: 日本フードファクター学会
  • Place of Presentation: 東京都
  • Year and Date: 2008-11-17
• [Presentation] NMR-メタボリック・プロファイリング法による緑茶ポリフェノールEGCGの生理活性評価 (2008)
  • Author(s): 藤村由紀ら
  • Organizer: メタボロームシンポジウム
  • Place of Presentation: 山形県
  • Year and Date: 2008-10-31
• [Presentation] 分子標的抗がん剤としての緑茶カテキンEGCG (2008)
  • Author(s): 立花宏文
  • Organizer: 日本カテキン学会
  • Place of Presentation: 東京都
  • Year and Date: 2008-08-22
• [Presentation] 緑茶カテキン受容体67LRはEGCGのin vivoにおける抗がん作用に必須である (2008)
  • Author(s): 塚本俊太郎ら
  • Organizer: 日本栄養・食糧学会大会
  • Place of Presentation: 埼玉県
  • Year and Date: 2008-05-02
• [Presentation] MYPT1はEGCGのin vivoにおける抗がん作用に必須である (2008)
  • Author(s): 弘津圭祐ら
  • Organizer: 日本栄養・食糧学会大会
  • Place of Presentation: 埼玉県
  • Year and Date: 2008-05-02
• [Presentation] 茶葉カテキンによるlipid raftの解裂とアレルギー疾患の改善 (2008)
  • Author(s): 立花宏文
  • Organizer: 日本小児東洋医学会学術集会
  • Place of Presentation: 東京都
  • Year and Date: 2008-04-26
• [Presentation] カテキンシグナリング : 緑茶カテキン受容体を介した機能性発現機構 (2008)
  • Author(s): 立花宏文
  • Organizer: 日本農芸化学会
  • Place of Presentation: 名古屋市
  • Year and Date: 2008-03-29
• [Presentation] 緑茶カテキン受容体67LRを介したカテキンの機能性発現機構 (2008)
  • Author(s): 立花宏文
  • Organizer: 第81回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2008-03-17
• [Presentation] 緑茶カテキン受容体67LR を介したカテキンの機能性発現機構 (2008)
  • Author(s): 立花宏文
  • Organizer: 第81回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2008-03-17
• [Presentation] 緑茶カテキン受容体67LRを介したカテキンの機能性発現機構 (2008)
  • Author(s): 立花宏文
  • Organizer: 日本薬理学会
  • Place of Presentation: 横浜市
  • Year and Date: 2008-03-17
• [Presentation] 緑茶カテキン受容体67LRを介しかカテキンの機能性発現機構 (2008)
  • Author(s): 立花宏文
  • Organizer: 日本薬理学会
  • Place of Presentation: 横浜市
  • Year and Date: 2008-03-17
• [Presentation] (2007)
  • Author(s): Tachibana, H., et. al.
  • Organizer: International Conference on Food Factors for Health Promotion
  • Place of Presentation: 京都国際会館
  • Year and Date: 2007-11-30
• [Presentation] Relationship between the biological activities of methylated derivatives of EGCG and their cell surface binding activities (2007)
  • Author(s): Yano, S, et. al.
  • Organizer: International Conference on Food Factors for Health Promotion
  • Place of Presentation: 京都国際会館
  • Year and Date: 2007-11-30
• [Presentation] The 67 kDa laminin receptor mediates anti-allergic effects of epiga-ocatech.in-3-0-(3-0-methy)gallate (2007)
  • Author(s): Fujimura, Y., et. al.
  • Organizer: International Conference on Food Factors for Health Promotion
  • Place of Presentation: 京都国際会館
  • Year and Date: 2007-11-30
• [Presentation] Identification of eukaryotic translation elongation factor lA as a downstream mediator of EGCG signalling through 67-kDa laminin receptor (2007)
  • Author(s): Umeda, D., et. al.
  • Organizer: International Conference on Food Factors for Health Promotion
  • Place of Presentation: 京都国際会館
  • Year and Date: 2007-11-29
• [Presentation] Green tea polyphenol EGCG signaling through the 67kDa laminin receptor (2007)
  • Author(s): Tachibana, H.
  • Organizer: 3rd International Conference on Polyphenols and Health
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2007-11-28
• [Presentation] Green tea polyphenol EGCG signaling through the 67kDa laminin receptor (2007)
  • Author(s): Hirofumi Tachibana
  • Organizer: International Conference on Polyphenols and Health
  • Place of Presentation: 京都国際会館
  • Year and Date: 2007-11-28
• [Presentation] ラット平滑筋細胞株A7r5に対するepigallocatechin-3-gallateの細胞増殖促進作用 (2007)
  • Author(s): 長友 俊介, ら
  • Organizer: 日本農芸化学会西日本、中四国支部合同大会
  • Place of Presentation: 山口大学
  • Year and Date: 2007-09-11
• [Presentation] 「べにふうき」緑茶の作用機作と期待される機能 (2007)
  • Author(s): 立花 宏文
  • Organizer: 日本食品科学工学会大会
  • Place of Presentation: 中村学園大学
  • Year and Date: 2007-09-07
• [Presentation] 緑茶カテキン受容体67LRを介したカテキン類の機能性発現とその結合様式 (2007)
  • Author(s): 立花 宏文
  • Organizer: 日本カテキン学会
  • Place of Presentation: 静銀ホール
  • Year and Date: 2007-08-24
• [Presentation] Prevention of allergy by dietary polyphenols (2007)
  • Author(s): Hirofumi Tachibana
  • Organizer: 日本食品免疫学会国際粘膜免疫学会合同大会
  • Place of Presentation: 品川プリンスホテル
  • Year and Date: 2007-07-11
• [Presentation] 緑茶カテキン受容体67LRを介したEGCGのシグナル伝達機構 (2007)
  • Author(s): 立花 宏文
  • Organizer: 日本栄養・食糧学会
  • Place of Presentation: 京都国際会館
  • Year and Date: 2007-05-19
• [Presentation] Molecular basis for inhibition of IgE production by tea polyphenol strictinin (2007)
  • Author(s): Tachibana, H., et. al.
  • Organizer: 国際0-CHA学術会議
  • Place of Presentation: 静岡県立大学
• [Presentation] Green tea polyphenol EGCG signalling through 67-kDa laminin receptor (2007)
  • Author(s): Umeda, D., et. al.
  • Organizer: 国際0-CHA学術会議
  • Place of Presentation: 静岡県立大学
• [Presentation] Structure-activity relationship of the 67 kDa laminin receptor-mediated function of tea polyphenols (2007)
  • Author(s): Fujimura, Y., et. al.
  • Organizer: 国際0-CHA学術会議
  • Place of Presentation: 静岡県立大学
• [Presentation] Identification of EGCG binding site in the green tea polyphenol receptor 67LR (2007)
  • Author(s): Ogawa, N., et. al.
  • Organizer: 国際0-CHA学術会議
  • Place of Presentation: 静岡県立大学
• [Presentation] Green Tea polyphenol EGCG-induced cell death pathway though the 67kDa laminin receptor (2007)
  • Author(s): Goto, Y., et. al.
  • Organizer: 国際0-CHA学術会議
  • Place of Presentation: 静岡県立大学
• [Presentation] Downregulation of the high-affinity IgE receptor expression on mast cells by green tea catechin EGCG (2007)
  • Author(s): Hasegawa, Y., et. al.
  • Organizer: 国際0-CHA学術会議
  • Place of Presentation: 静岡県立大学
• [Book] Food Factors for Health Promotion (2009)
  • Author(s): Tachibana, H., (Yoshikawa, T. ed.)
• [Book] Food Factors for Health Promotion (2009)
  • Author(s): Tachibana, H.
  • Total Pages: 14
  • Publisher: Karger
• [Book] Green Tea and Health Research (2009)
  • Author(s): Fujimura, Y., Tachibana, H.
  • Total Pages: 43
  • Publisher: Nova Pubilisher
• [Book] 栄養学研究の最前線 (2008)
  • Author(s): 立花宏文(小川正、河田照雄、寺尾純二編集)
• [Book] 食品機能性の科学 (2008)
  • Author(s): 立花宏文(食品機能性の科学編集委員会編集)
• [Book] 緑茶カテキン受容体を介したEGCG(小川正, 河田照雄, 寺尾純二編集) の機能性発現とシグナリング(小川正、河田照雄、寺尾純二) (2008)
  • Author(s): 立花宏文
  • Publisher: 栄養学研究の最前線
• [Book] 栄養学研究の最前線 (2008)
  • Author(s): 立花宏文
  • Publisher: 建帛社
• [Book] 食品機能性の科学 (2008)
  • Author(s): 立花宏文
  • Publisher: 産業技術サービスセンター
• [Book] Research Focus on Natural products and the Body's Immune and Inflammatory (2007)
  • Author(s): Tachibana, H.
  • Total Pages: 19
  • Publisher: Nova Publishers
• [Book] 茶の効能と応用開発、抗アレルギー作用 (2006)
  • Author(s): 藤村由紀, 山本(前田)万里, 立花宏文
  • Total Pages: 9
  • Publisher: シーエムシー出版
• [Patent(Industrial Property Rights)] エピガロカテキンガレート誘導体及びそれを含む医薬組成物 (2010)
  • Inventor(s): 立花宏文, 高橋孝志, 田中浩二
  • Industrial Property Rights Holder: 国立大学法人九州大学,国立大学法人東京工業大学
  • Industrial Property Number: 2010-028974
  • Filing Date: 2010-02-12
• [Patent(Industrial Property Rights)] ガロイルカテキン類の抗酸化活性の促進方法 (2008)
  • Inventor(s): 立花宏文
  • Industrial Property Rights Holder: 国立大学法人九州大学
  • Industrial Property Number: 2008-332205
  • Filing Date: 2008-12-26