| Budget Amount *help |
¥48,750,000 (Direct Cost: ¥37,500,000、Indirect Cost: ¥11,250,000)
Fiscal Year 2008: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
Fiscal Year 2007: ¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
Fiscal Year 2006: ¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
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| Research Abstract |
Ubiquitination serves as a signal for protein degradation by the proteasome as well as regulates various aspects of membrane trafficking. Furthermore, ubiquitination has been revealed to play a crucial role in cytokinesis. On the other hand, membrane trafficking is regulated by the Arf and Rab families of small GTPases. In this study, I have studied on regulation of membrane trafficking and cytokinesis by proteins that not only bind to the small GTPases but also undergo ubiquitination and/or ubiquitin binding, and identified a part of the regulatory mechanisms.
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