Molecular basis on function and clinical implication of neuropeptide PACAP

• Project/Area Number: 18209009
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General pharmacology
• Research Institution: Osaka University
• Principal Investigator: BABA Akemichi Osaka University, 大学院薬学研究科, 教授 (70107100)
• Co-Investigator(Kenkyū-buntansha): HASHIMOTO Hitoshi 大阪大学, 大学院薬学研究科, 准教授 (30240849) ; SHINTANI Norihito 大阪大学, 大学院薬学研究科, 助教 (10335367) ; SHIODA Seiji 昭和大学, 医学部, 教授 (80102375) ; YADA Toshihiko 自治医科大学, 医学部, 教授 (60166527) ; HASHIMOTO Ryota 大阪大学, 子どものこころの分子制御機構研究センター, 特任准教授 (10370983)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥48,880,000 (Direct Cost: ¥37,600,000、Indirect Cost: ¥11,280,000); Fiscal Year 2008: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000); Fiscal Year 2007: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000); Fiscal Year 2006: ¥22,360,000 (Direct Cost: ¥17,200,000、Indirect Cost: ¥5,160,000)
• Keywords: 中枢 / 末梢神経 / 神経ペプチドPACAP / 遺伝子改変マウス / 精神疾患・障害 / 統合失調症 / 概日リズム / プロスタグランジン / 膵島過形成 / ミトコンドリア / PACAP / SNPs(一塩基多型) / プロスタグーンジンD_2合成酵素 / 糖尿病

Research Abstract

1.PACAP 遺伝子欠損マウスが、統合失調症のマウスモデルであること、その分子基盤の一端を実証した。併せて、臨床的にPACAP 遺伝子の変異がヒト統合失調症の脆弱因子であることを明らかにした。
2.脳では生物時計調節因子としてのプロスタグランジンD2 の役割解明、膵臓では、RegIIIβ、HPGB という機能未知遺伝子について、各々、組織リモデリング、ミトコンドリア形態制御因子としての機能を持つことを明らかにした。

Research Products

• [Journal Article] Depression-like behavior in the forced swimming test in PACAP-deficient mice: amelioration by the atypical antipsychotic risperidone (2009)
  • Author(s): Hashimoto H(1),Hashimoto R(2), Shintani N(3) , and Baba A(12) ( 計12 名)
  • Journal Title: Journal of Neurochemistry, accept Pages: 0-0
  • Peer Reviewed
• [Journal Article] Synaptic scaffolding molecule binds to and regulates vasoactive intestinal polypeptide type-1 receptor in epithelial cells (2009)
  • Author(s): Heon Yung Gee, et al.
  • Journal Title: Gastroenterology (in press. )
  • Peer Reviewed
• [Journal Article] Inhibitory effect of osemozotan, an serotonin 1A-receptor agonist, on methamphetamine-induced c-Fos-expression in prefrontal cortical neurons (2009)
  • Author(s): Tsuchida R, et al.
  • Journal Title: Biol. Pharm. Bull. (in press. )
  • Peer Reviewed
• [Journal Article] An antihyperkinetic action by the serotonin 1A-receptor agonist osemozotan co-administered with psychostimulants or the non-stimulant atomoxetine in mice (2009)
  • Author(s): Tsuchida R, et al.
  • Journal Title: J. Pharmacol. Sci. (in press. )
  • Peer Reviewed
• [Journal Article] Developmental changes in Ca^<2+> homeostasis and contractility in gallbladder smooth muscle (2009)
  • Author(s): Camello-Almaraz C, et al.
  • Journal Title: Am. J. Physiol. Cell Physiol. (in press. )
  • Peer Reviewed
• [Journal Article] ANa+/Ca2+ exchanger isoform, NCX1, is involved in retinal cell death after N-methyl-D-aspartate injection and ischemia-reperfusion (2009)
  • Author(s): Inokuchi Y., et al.
  • Journal Title: J. Neurosci. Res. (in press. )
  • Peer Reviewed
• [Journal Article] Lack of light-induced elevation of renal sympathetic nerve activity and plasma corticosterone levels in PACAP-deficient mice (2008)
  • Author(s): Hatanaka M, Shintani N(3), Hashimoto H(6), and Baba A(10)(計10 名)
  • Journal Title: eurosci. Lett. 444 Pages: 153-156
  • Peer Reviewed
• [Journal Article] Markedly reduced white adipose tissue and increased insulin sensitivity in Adcyap1-deficient mice (2008)
  • Author(s): Tomimoto S, Ojika T, Shintani N(3) , Hashimoto H(4), Hamagami K, Ikeda K, Nakata M, Yada T(8), Sakurai Y, Shimada T, Morita Y, Ishida C, Baba A(13)(計8名)
  • Journal Title: J. Pharmacol. Sci. 107 Pages: 41-48
  • NAID: 10024320415
  • Peer Reviewed
• [Journal Article] Gonadotropin-releasing hormone inhibits pituitary adenylyl cyclase-activating polypeptide coupling to 3'5'-cyclic adenosine-5'-monophosphate pathway in LbetaT2 gonadotrope cells through novel protein kinase C isoforms and phosphorylation of pituitary adenylyl cyclase-activating polypeptide type I receptor. (2008)
  • Author(s): Lariviere S, et al.
  • Journal Title: Endocrinology 149 Pages: 6389-6398
  • Peer Reviewed
• [Journal Article] Retardation of retinal vascular development in apelin-deficient mice (2008)
  • Author(s): Kasai A, et al.
  • Journal Title: Arterioscler. Thromb. Vasc. Biol. 28 Pages: 1717-1722
  • Peer Reviewed
• [Journal Article] Lack of light-induced elevation of renal sympathetic nerve activity and plasma corticosterone levels in PACAP-defident mice (2008)
  • Author(s): Hatanaka M, et al.
  • Journal Title: Neurosci. Lett. 444 Pages: 153-156
  • Peer Reviewed
• [Journal Article] Inhibition of the Na^+/Ca^<2+> exchanger suppresses torsades de pointes in an intact heart model of long QT syndrome-2 and long QT syndrome-3 (2008)
  • Author(s): Milberg P, et al.
  • Journal Title: Heart Rhythm 5 Pages: 1444-1452
  • Peer Reviewed
• [Journal Article] Endoplasmic reticulum Ca2^<2+> dysregulation and endoplasmic reticulum stress following in vitro neuronal ischemia : role of Na^+-K^+-Cl^- cotransporter (2008)
  • Author(s): Chen X, et al.
  • Journal Title: J. Neurochem. 106 Pages: 1563-1576
  • Peer Reviewed
• [Journal Article] Involvements of PHI-nitric oxide and PACAP-BK channel in the sustained relaxation of mouse gastric fundus (2008)
  • Author(s): Hagi K, et al.
  • Journal Title: Eur. J. Pharmacol. 590 Pages: 80-86
  • Peer Reviewed
• [Journal Article] PACAP provides colonic protection against dextran sodium sulfate induced colitis (2008)
  • Author(s): Azuma Y, et al.
  • Journal Title: J. Cell. Physiol. 216 Pages: 111-119
  • Peer Reviewed
• [Journal Article] Markedly Reduced White Adipose Tissue and Increased Insulin Sensitivity in Adcyap1-Dieficient Mice (2008)
  • Author(s): Tomimoto S, et al
  • Journal Title: J. Pharmacol. Sci 107 Pages: 41-48
  • Peer Reviewed
• [Journal Article] PACAP is transiently expressed in anterior pituitary gland of rats : In situ hybridization and cell immunoblot assay studies (2008)
  • Author(s): Heinzlmann A, et al.
  • Journal Title: Peptides 29 Pages: 571-577
  • Peer Reviewed
• [Journal Article] 統合失調症関連因子とPACAP (2008)
  • Author(s): 尾形 勝弥, 他
  • Journal Title: 医学のあゆみ 227 Pages: 971-973
• [Journal Article] PACAP受容体 (2008)
  • Author(s): 橋本 均, 他
  • Journal Title: 日薬理誌 132 Pages: 189-191
  • NAID: 10024383899
• [Journal Article] Neural networks of several novel neuropeptides involved in feeding regulation (2008)
  • Author(s): Shioda S, et al.
  • Journal Title: Nutrition 24 Pages: 848-853
  • Peer Reviewed
• [Journal Article] Suppression of Ganglion Cell Death by PACAP Following Optic Nerve Transection in the Rat (2008)
  • Author(s): Seki T, et al.
  • Journal Title: J Mol Neurosci 36 Pages: 57-60
  • Peer Reviewed
• [Journal Article] Changes in the Expression of PACAP-like Compounds During the Embryonic Development of the Earthworm Eisenia fetida (2008)
  • Author(s): Boros A, et al.
  • Journal Title: J Mol Neurosci 36 Pages: 157-165
  • Peer Reviewed
• [Journal Article] The presence and distribution of pituitary adenylate cyclase activating polypeptide and its receptor in the snail Helix pomatia (2008)
  • Author(s): Hernadi L, et al.
  • Journal Title: Neuroscience 155 Pages: 387-402
  • Peer Reviewed
• [Journal Article] Role of PACAP in ischemic neural death (2008)
  • Author(s): Ohtaki H, et al.
  • Journal Title: J Mol Neurosci 36 Pages: 16-25
  • Peer Reviewed
• [Journal Article] PAC1 receptor localization in a model nervous system : light and electron microscopic immunocytochemistry on the earthworm ventral nerve cord ganglia (2008)
  • Author(s): Molnar L, et al.
  • Journal Title: Regul Pept 145 Pages: 96-104
  • Peer Reviewed
• [Journal Article] Pituitary adenylate cyclase-activating polypeptide (PACAP) type 1 receptor (PAC1R) co-localizes with activity-dependent neuroprotective protein (ADNP) in the mouse brains (2008)
  • Author(s): Nakamachi T, et al.
  • Journal Title: Regul Pept 145 Pages: 88-95
  • Peer Reviewed
• [Journal Article] Effect of pituitary adenylate cyclase-activating polypeptide (PACAP)on prolactin and somatolactin release from the goldfish pituitary in vitro (2008)
  • Author(s): Matsuda K, et al.
  • Journal Title: Regul Pept 145 Pages: 72-79
  • Peer Reviewed
• [Journal Article] Distribution and localization of pituitary adenylate cyclase-activating polypeptide-specific receptor (PAC1R)in the rostral migratory stream of the infant mouse brain (2008)
  • Author(s): Matsuno R, et al.
  • Journal Title: Regul Pept 145 Pages: 80-87
  • Peer Reviewed
• [Journal Article] A genetic variation in the dysbindin gene (DTNBP1) is associated with memory performance in healthy controls (2008)
  • Author(s): Hashimoto R, et al.
  • Journal Title: The World Journal of Biological Psychiatry (in press)
  • Peer Reviewed
• [Journal Article] Effect of the BDNF and the ApoE polymorphisms on disease progression in preclinical Alzheimer's disease (2008)
  • Author(s): Hashimoto R, et al.
  • Journal Title: Genes, Brain and Behavior (in press)
  • Peer Reviewed
• [Journal Article] Abnormal microstructures of the basal ganglia in schizophrenia revealed by diffusion tensor imaging (2008)
  • Author(s): Hashimoto R, et al.
  • Journal Title: The World Journal of Biological Psychiatry (in press)
  • Peer Reviewed
• [Journal Article] Impaired long-term memory retention and working memory in sdy mutant mice with a deletion in Dtnbp 1, a susceptibility gene for schizophrenia (2008)
  • Author(s): Takao K, et al.
  • Journal Title: Mol Brain 1 Pages: 11-11
  • Peer Reviewed
• [Journal Article] Behavioral abnormalities and dopamine reductions in sdy mutant mice with a deletion in Dtnbp1, a susceptibility gene for schizophrenia (2008)
  • Author(s): Hattori S, et al.
  • Journal Title: Biochem Biophys Res Commun 373 Pages: 298-302
  • Peer Reviewed
• [Journal Article] Dose Dependent Effect of the Val66Met Polymorphism of the Brain-Derived Neurotrophic Factor Gene on Memory-Related Hippocampal Activity (2008)
  • Author(s): Hashimoto R, et al.
  • Journal Title: Neuroscience Res 61 Pages: 360-367
  • Peer Reviewed
• [Journal Article] A possible association between missense polymorphism of the Breakpoint Cluster Region gene and lithium prophylaxis in bipolar disorder (2008)
  • Author(s): Masui T, et al.
  • Journal Title: Progress in Neuro-Psychopharmacology & Biological Psychiatry 32 Pages: 204-208
  • Peer Reviewed
• [Journal Article] 精神疾患のトランスレーショナルリサーチ、Translational research in mentaldisorder (2008)
  • Author(s): 橋本亮太, 他
  • Journal Title: 神経化学 47 Pages: 348-352
• [Journal Article] 統合失調症の病態研究の最先端 (2008)
  • Author(s): 石井良平, 他
  • Journal Title: 臨床精神医学 37 Pages: 1305-1314
• [Journal Article] PACAP provides colonic protection against dextran sodium sulfate induced colitis (2008)
  • Author(s): Azuma YT
  • Journal Title: J Cell Physiol (In press)
  • Peer Reviewed
• [Journal Article] Abnormal microstructures of the basal ganglia in schizophrenia revealed by diffusion tensor inmaging (2008)
  • Author(s): Hashimoto R
  • Journal Title: The World Journal of Biological Psychiatry (in press)
  • Peer Reviewed
• [Journal Article] Neuropsychotoxicity of Abused Drugs: Effects of Serotonin Receptor Ligands on Methamphetamine-and Cocaine-Induced Behavioral Sensitization in Mice (2008)
  • Author(s): Ago Y
  • Journal Title: J Pharmacol Sci 106 Pages: 15-21
  • Peer Reviewed
• [Journal Article] A possible association between missense polymorphism of the Breakpoint Cluster Region gene and lithium prophylaxis in bipolar disorder (2008)
  • Author(s): Masui T
  • Journal Title: Progress in Neuro-Psychopharmacology & Biological Psychiatry 32 Pages: 204-208
  • Peer Reviewed
• [Journal Article] Distribution and localization of pituitary adenylate cyclase activating polypeptide-specific receptor (PAC1R) in the rostral migratory stream of the infant mouse brain (2008)
  • Author(s): Matsuno R
  • Journal Title: Regul Pept 145(1-3) Pages: 80-87
  • Peer Reviewed
• [Journal Article] Pituitary adenylate cyclase-activating polypeptide (PACAP) type 1 receptor (PAC1R) colocalize with activity-dependent neuroprotective protein (ADNP) in the mouse brain (2008)
  • Author(s): Nakamachi T
  • Journal Title: Regul Pept 145(1-3) Pages: 88-95
  • Peer Reviewed
• [Journal Article] 統合失調症の分子病態とPACAP (2008)
  • Author(s): 新谷紀人
  • Journal Title: 脳と精神の医学 (In press)
• [Journal Article] Pituitary adenylate cyclase-activating polypeptide is associated with schizophrenia (2007)
  • Author(s): Hashimoto R (1) , Hashimoto H (2) , Shintani N(3), and Baba A(25)(計25名)
  • Journal Title: Mol. Psychiatry 12 Pages: 1026-1032
  • Peer Reviewed
• [Journal Article] A novel DISC1-interacting partner DISC1-Binding Zinc-finger protein: implication in the modulation of DISC1-dependent neurite outgrowth (2007)
  • Author(s): Hattori T, Hashimoto H(8), Shintani N(9), Baba A(10), and Katayama T(計16名)
  • Journal Title: Mol. Psychiatry 12 Pages: 398-407
  • Peer Reviewed
• [Journal Article] PACAP in the glucose and energy homeostasis:physiological role and therapeuticpotential. In: Therapeutic Potentialof VIP and PACAP (2007)
  • Author(s): Nakata M, and Yada T
  • Journal Title: Curr Pharm Des 13(11) Pages: 1105-1112
  • Peer Reviewed
• [Journal Article] Pituitary adenylate cyclase-activating polypeptide is associated with schizophrenia (2007)
  • Author(s): Hashimoto R
  • Journal Title: Mol Psychiatry 12 Pages: 1026-1032
  • Peer Reviewed
• [Journal Article] A novel DISCI-interacting partner DBZ (DISC1-Binding Zinc finger protein): implication in the modulation of DISC1-dependent neurite outgrowth (2007)
  • Author(s): Hattori T
  • Journal Title: Mol Psychiatry 12 Pages: 398-407
  • Peer Reviewed
• [Journal Article] Methamphetamine-induced hyperactivity and behavioral sensitization in PACAP deficient mice (2007)
  • Author(s): Fujii H
  • Journal Title: Peptides 28(9) Pages: 1674-1679
  • Peer Reviewed
• [Journal Article] Anxiety-like and exploratory behaviors of isolation-reared mice in the staircase test (2007)
  • Author(s): Ago Y
  • Journal Title: J Pharmacol Sci 104(2) Pages: 153-158
  • Peer Reviewed
• [Journal Article] Production of monocyte chemoattractant protein-1 and cytokine-induced neutrophil chemoattractant-1 in rat brain is stimulated by intracerebroventricular administration of an endothelin ETB receptor agonist (2007)
  • Author(s): Koyama Y
  • Journal Title: Neuroreport 18(12) Pages: 1275-1279
  • Peer Reviewed
• [Journal Article] Edaravone (3-Methy-l-phenyl-2-pyrazolin-5-one), a Radical Scavenger, Prevents 1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-induced Neurotoxicity in Substantia Nigra but Not the Striatum (2007)
  • Author(s): Kawasaki T
  • Journal Title: J Pharmacol Exp Ther 322 Pages: 274-281
  • Peer Reviewed
• [Journal Article] Nitric Oxide-Induced Apoptosis in Cultured Rat Astrocytes: Protection by Edaravone, a Radicla Scavenger (2007)
  • Author(s): Kawasaki T
  • Journal Title: Glia 55 Pages: 1325-1333
  • Peer Reviewed
• [Journal Article] Ritanserin Reverses Repeated Methamphetamine-Induced Behavioral and Neurochemical Sensitization in Mice (2007)
  • Author(s): Ago Y
  • Journal Title: Synapse 61 Pages: 757-763
  • Peer Reviewed
• [Journal Article] Roles of postsynaptic serotonin receptors in risperidone-induced increase in acetylcholine release in rat prefrontal contrex (2007)
  • Author(s): Sato M
  • Journal Title: Eur. J. Pharmacol 559 Pages: 155-160
  • Peer Reviewed
• [Journal Article] Edaravone, a Radical Scavenger, Inhibis Mitochondrial Permeability Transition Pore in Rat Brain (2007)
  • Author(s): Takayasu Y
  • Journal Title: J. Pharmacol Sci 103 Pages: 434-437
  • Peer Reviewed
• [Journal Article] AMPA-mediated excitotoxicity in oligodendorocytes: role for Na(+)-K-Cl(-) co-transport and reversal of Na(+)/Ca(2+) exchanger (2007)
  • Author(s): Chen H
  • Journal Title: J Neurochem. 102(6) Pages: 1783-1795
  • Peer Reviewed
• [Journal Article] Ca2+ extrusion in aged smooth muscle cells (2007)
  • Author(s): Gomez-Pinilla PJ
  • Journal Title: Biochem Pharmacol 74(6) Pages: 860-869
  • Peer Reviewed
• [Journal Article] Intracerebroventricular administration of an endothelin ETB receptor agonist increases expression oftissue inhibitor of matrix metalloprotease-1 and -3 in rat brain (2007)
  • Author(s): Koyama Y
  • Journal Title: Neuroscience 147 Pages: 620-630
  • Peer Reviewed
• [Journal Article] A possible association between the Val158Met polymorphism of the catechol-0-methyl transferase gene and the personality trait of harm avoidance in Japanese healthy subjects (2007)
  • Author(s): Hashimoto R
  • Journal Title: Neurosci lett 428(1) Pages: 17-20
  • Peer Reviewed
• [Journal Article] Enriched environments influence depression-related behavior in adult mice and the survival of newborn cells in their hippocampi (2007)
  • Author(s): Hattori S
  • Journal Title: Behavioural Brain Research 180(1) Pages: 69-76
  • Peer Reviewed
• [Journal Article] Postsynaptic density: A key convergent site for schizophrenia susceptibility factors and possible target for drug development (2007)
  • Author(s): Hashimoto R
  • Journal Title: Drugs Today (Barc) 43(9) Pages: 645-654
  • Peer Reviewed
• [Journal Article] Localization, characterization and function of pituitary adenylate cyclase-activating polypeptide during brain development (2007)
  • Author(s): Watanabe J
  • Journal Title: Peptides 28(9) Pages: 1713-1719
• [Journal Article] PACAP in the glucose and energy homeostasis: physiological role and therapeutic potential. In: Therapeutic Potential of VIP and PACAP (2007)
  • Author(s): Nakata M
  • Journal Title: Curr Pharm Des 13(11) Pages: 1105-1112
  • Peer Reviewed
• [Journal Article] Molecular Pharmacologic Approaches to Functional A nalysis of New Biological Molecules for Drug Discovery (2007)
  • Author(s): Baba A
  • Journal Title: Yakugaku Zasshi 127(10) Pages: 1643-1654
• [Journal Article] Recent studies on the trimethyltin actions in central nervous systems (2007)
  • Author(s): Shintani N
  • Journal Title: Yakugaku Zasshi 127(3) Pages: 451-461
  • NAID: 110006240154
• [Journal Article] The neuropeptide PACAP and neuropsychological function: unexpected insights from mouse mutants (2007)
  • Author(s): Hashimoto H
  • Journal Title: Seikagaku 79(4) Pages: 375-379
  • NAID: 10020162227
• [Journal Article] 新しいGPCRリガンド研究の現状と展望〜神経ペプチドPACAPの生理機能 (2007)
  • Author(s): 新谷紀人
  • Journal Title: ホルモンと臨床 55 Pages: 131-139
• [Journal Article] 統合失調症とセロトニン1A受容体 (2007)
  • Author(s): 吾郷由希夫
  • Journal Title: 脳21 10(3) Pages: 44-48
• [Journal Article] 遺伝子改変マウスの表現型解析法:SHIRPA一次スクリーニング法 (2007)
  • Author(s): 笠井淳司
  • Journal Title: 日本薬理学雑誌 130 Pages: 281-285
• [Journal Article] 動物個体を用いた概日リズム解析法 (2007)
  • Author(s): 川口ちひろ
  • Journal Title: 日本薬理学雑誌 130 Pages: 193-199
• [Journal Article] (2007)
  • Author(s): 馬場明道
  • Journal Title: 神経ペプチドPACAP-新しい創薬標的分子探索へ 遺伝子医学MOOK(8) Pages: 168-172
• [Journal Article] (2007)
  • Author(s): 新谷紀人
  • Journal Title: PACAP欠損マウス, Keyword精神第4版 Pages: 214-215
• [Journal Article] (2007)
  • Author(s): 馬場明道
  • Journal Title: ビタミン, New薬理学改訂第5版 Pages: 193-203
• [Journal Article] 神経ペプチドPACAPの生理機能 (2007)
  • Author(s): 新谷 紀人, ほか
  • Journal Title: ホルモンと臨床 55・2 Pages: 131-139
  • NAID: 10018586363
• [Journal Article] 中枢神経系におけるトリメチルスズの作用 (2007)
  • Author(s): 新谷 紀人, ほか
  • Journal Title: 薬学雑誌 127・3 Pages: 451-461
  • NAID: 110006240154
• [Journal Article] Serotonergic inhibition of intense jumping behavior in mice lacking PACAP (Adcyap1-/-) (2006)
  • Author(s): Shintani N(1), Hashimoto H(2), and Baba A(9)(計9名)
  • Journal Title: Ann N Y Acad Sci 1070 Pages: 545-549
  • Peer Reviewed
• [Journal Article] New insights into the central PACAPergic system from the phenotypes in PACAPand PACAP receptor-knockout mice (2006)
  • Author(s): Hashimoto H, Shintani N, Baba A
  • Journal Title: Ann N Y Acad Sci 1070 Pages: 75-89
  • Peer Reviewed
• [Journal Article] Psychostimulant-induced attenuation of hyperactivity and prepulse inhibition deficits in Adcyap1-deficient mice (2006)
  • Author(s): Tanaka K, Shintani N(2), Hashimoto H(3) , Hashimoto R(7) , and Baba A(12)
  • Journal Title: J. Neurosci. 26 Pages: 5091-5097
  • Peer Reviewed
• [Journal Article] Pituitary adenylate cyclase-activating polypeptide (PACAP) decreases ischemic neuronal cell death in association with IL-6 (2006)
  • Author(s): Ohtaki H, Hashimoto H(8), Shintani N(9), Baba A(10), and Shioda S(15)(計15名)
  • Journal Title: Proc Natl Acad Sci U S A 103・19 Pages: 7488-7493
  • Peer Reviewed
• [Journal Article] Modification of cocaine-induced behavioral and neurochemical effects by serotonln_<1A> receptor agonist/antagonist in mice (2006)
  • Author(s): Nakamura, S., et. al.
  • Journal Title: Synapse 60・7 Pages: 479-484
• [Journal Article] Serotonergic inhibition of intense jumping behavior in mice lacking PACAP (Adcyap1^<-/->) (2006)
  • Author(s): Shintani, N., et. al.
  • Journal Title: Ann N Y Acad Sci 1070 Pages: 545-549
• [Journal Article] Lack of trimethyltin (TMT)-induced elevation of plasma corticosterone in PACAP-deficient mice (2006)
  • Author(s): Morita, Y., et. al.
  • Journal Title: Ann N Y Acad Sci 1070 Pages: 450-456
• [Journal Article] Inhibition of self-renewal and induction of neural differentiation by PACAP in neural progenitor cells (2006)
  • Author(s): Hirose, M., et. al.
  • Journal Title: Ann N Y Acad Sci 1070 Pages: 342-347
• [Journal Article] New insights into the central PACAPergic system from the phenotypes in PACAP-and PACAP receptor-knockout mice (2006)
  • Author(s): Hashimoto, H., et. al.
  • Journal Title: Ann N Y Acad Sci 1070 Pages: 75-89
• [Journal Article] Psychostimulant-induced attenuation of hyperactivity and prepulse inhibition deficits in Adcyapl-deficient mice (2006)
  • Author(s): Tanaka, K., et. al.
  • Journal Title: J Neurosci 26・19 Pages: 5091-5097
• [Journal Article] Pituitary adenylate cyclase-activating polypeptide (PACAP) decreases ischemicneuronal cell death in association with IL-6 (2006)
  • Author(s): Ohtaki, H., et. al.
  • Journal Title: Proc Natl Acad Sci U S A 103・19 Pages: 7488-7493
• [Journal Article] Responsibility of β isoform of protein kinase C for the PACAP-induced differentiation of embryonic neural stem cells into astrocytes. (2006)
  • Author(s): Watanabe, J., et. al.
  • Journal Title: J Neurosci Res 84・8 Pages: 1645-1655
• [Journal Article] Signaling involved in pituitary adenylate cyclase-activating polypeptide-stimulated ADNP expression. (2006)
  • Author(s): Nakamachi, T., et. al.
  • Journal Title: Peptides 27・7 Pages: 1859-1864
• [Journal Article] Relationship between anorexigenic action of pituitary adenylate cyclase-activating polypeptide (PACAP) and that of corticotropin-releasing hormone (CRH) in the goldfish, Carassius auratus. (2006)
  • Author(s): Maruyama, K., et. al.
  • Journal Title: Peptides 27 27・7 Pages: 1820-1826
• [Journal Article] Effects of Pituitary Adenylate Cyclase-Activating Polypeptides (PACAP) and Vasoactive Intestinal Polypeptide (VIP) on Food Intake and Locomotor Activity in the Goldfish, Carassius auratsu. (2006)
  • Author(s): Matsuda K., et. al.
  • Journal Title: Ann NY Acad Sci 1070 Pages: 417-421
• [Journal Article] Neuroprotective effects of PACAP against kainic acid-induced neurotoxicity in ratretina. (2006)
  • Author(s): Seki, T., et. al.
  • Journal Title: Ann NY Acad Sci 1070 Pages: 531-534
• [Journal Article] PACAP Stimulates the Release of Interleukin-6 in Cultured Rat Muller Cells. (2006)
  • Author(s): Seki, T., et. al.
  • Journal Title: Ann NY Acad Sci 1070 Pages: 539-539
• [Journal Article] Pleiotropic Functions of PACAP in the CNS: Neuroprotection and Neurodevelopment. (2006)
  • Author(s): Shioda, S., et. al.
  • Journal Title: Ann NY Acad Sci 1070 Pages: 550-560
• [Journal Article] PACAP Receptor (PAC1-R) Expression in Rat and Rhesusu Monkey Thysmus. (2006)
  • Author(s): Tokuda, N., et. al.
  • Journal Title: Ann NY Acad Sci 1070 Pages: 581-585
• [Journal Article] Involvement of Protein Kinase in the PACAP-Induced Differentiation of Neural Stem Cells in to Astrocytes. (2006)
  • Author(s): Watanabe, J., et. al.
  • Journal Title: Ann NY Acad Sci 1070 Pages: 597-601
• [Journal Article] Pituitary adenylate cyclase-activating peptide (PACAP) stimulates production of interleukin-6 IL-6 in rat Muller cells. (2006)
  • Author(s): Nakatani, M., et. al.
  • Journal Title: Peptides 27・7 Pages: 1871-1876
• [Journal Article] Pituitary adenylate cyclase-activating polypeptide is associated with schizophrenia
  • Author(s): Hashimoto, R., et. al.
  • Journal Title: Mol Psychiatry (in press)
• [Journal Article] A novel DISC1-interacting partner DBZ (DISC1-Binding Zinc finger protein): implication in the modulation of DISC1-dependent neurite outgrowth
  • Author(s): Hattori, T., et. al.
  • Journal Title: Mol Psychiatry (in press)
• [Journal Article] PAC1 receptor localization in a model nervous system: light and electron microscopic immunocytochemistry on the earthworm ventral nerve cord ganglia.
  • Author(s): Molnar, L., et. al.
  • Journal Title: Regul Pept (in press)
• [Journal Article] Distribution and localization of pituitary adenylate cyclase activating polypeptide-specific receptor (PAC1R) in the rostral migratory stream of the infantmouse brain.
  • Author(s): Matsuno, R., et. al.
  • Journal Title: Regul Pept (in press)
• [Journal Article] Pituitary adenylate cyclase-activating polypeptide (PACAP) type 1 receptor (PAC1R) colocalizes with activity-dependent neuroprotective protein (ADNP) in the mouse brain.
  • Author(s): Nakamachi, T., et. al.
  • Journal Title: Regul Pept (in press)
• [Presentation] 新規細胞内分子HPGBによるミトコンドリア機能調節 (2009)
  • Author(s): 池田 和哉, 他
  • Organizer: 日本薬学会第129年会
  • Place of Presentation: 京都
• [Presentation] Effects of intracerebroventricular injection of agonists for PGD2 receptor CRTH2 on the open-field behavior in mice (2009)
  • Author(s): 羽場 亮太, 他
  • Organizer: 日本薬学会第129年会
  • Place of Presentation: 京都
• [Presentation] Functional roles of PACAP-Reg IIIβ signaling in pancreatic islet under diabetic condition (2009)
  • Author(s): 新谷 紀人, 他
  • Organizer: 第82回日本薬理学会年会
  • Place of Presentation: 横浜
• [Presentation] PACAP induces early growth response gene in cortical neuron (2009)
  • Author(s): 尾形 勝弥, 他
  • Organizer: 第82回日本薬理学会年会
  • Place of Presentation: 横浜
• [Presentation] Phenotypic changes associated with noggin-induced neuronal differentiation of embryonic stem (ES)cells (2009)
  • Author(s): 篠原 季久子, 他
  • Organizer: 第82回日本薬理学会年会
  • Place of Presentation: 横浜
• [Presentation] Impaired nocifensive behaviours and mechanical hyperalgesia, but enhanced thermal hyperalgesia in pituitary adenylate-cyclase activating polypeptide deficient mice (2009)
  • Author(s): Sandor K, et al.
  • Organizer: 30th Annual Winter Neuropeptide Conference
  • Place of Presentation: Colorado, USA
• [Presentation] L-PGDS-PGD2-CRTH2 signaling cascade specifically involved in light-induced phase advance of circadian rhythm (2009)
  • Author(s): Hatanaka M, et al.
  • Organizer: 第4回日本統合失調症学会
  • Place of Presentation: 大阪
• [Presentation] PACAP knockout mice, an animal model of psychomotor dysfunction-gene x environment (2009)
  • Author(s): Shintani N, et al.
  • Organizer: 第一回アジア統合失調症ワークショップ「統合失調症ワークショップシンポジウム」
  • Place of Presentation: 大阪
• [Presentation] Functional Analysis of One of the Susceptibility Genes for Schizophrenia; Pituitary Adenylate Cyclase-activating Polypeptide (2009)
  • Author(s): Yamada K, et al.
  • Organizer: 第一回アジア統合失調症ワークショップ「統合失調症ワークショップシンポジウム」
  • Place of Presentation: 大阪
• [Presentation] 反応性アストロサイトにおけるPACAP受容体発現とその機能的意義の解析 (2009)
  • Author(s): 中町 智哉, 他
  • Organizer: 第114回目本解剖学会総会・全国学術集会
  • Place of Presentation: 岡山
• [Presentation] マウスのドキソルビシン心筋障害モデルにおけるPituitary Adenylate Cyclase Activating Polyeptide (PACAP)の心筋保護効果 (2009)
  • Author(s): 森 敬善, 他
  • Organizer: 第114回日本解剖学会総会・全国学術集会
  • Place of Presentation: 岡山
• [Presentation] 内因性PACAPによる虚血性神経細胞死抑制作用の解析 (2009)
  • Author(s): 中町 智哉, 他
  • Organizer: 第114回日本解剖学会総会・全国学術集会
  • Place of Presentation: 岡山
• [Presentation] IMPAIRED PREPULSE INHIBITION OF ACOUSTIC STARTLE RESPONSE IN JAPANESE PATIENTS WITH SCHIZOPHRENIA (2009)
  • Author(s): Takahashi H, et al.
  • Organizer: The 1^<st> Asian Workshop on Schizophrenia Research
  • Place of Presentation: Osaka, Japan
• [Presentation] 統合失調症の未病と予防「統合失調症未病と広汎性発達障害との類似点と相違点」 (2009)
  • Author(s): 橋本亮太, 他
  • Organizer: 日本統合失調症学会第4回大会
  • Place of Presentation: 大阪
• [Presentation] Symposium: Pathogenesis of schizophrenia, dysbindin and pathogenesis of schizophrenia (2009)
  • Author(s): Hashimoto R
  • Organizer: 2^<nd> International Congress of Biological Psychiatry
  • Place of Presentation: Santiago, Chili
• [Presentation] 統合失調症の病態と前頭葉機能 (2008)
  • Author(s): 橋本亮太
  • Organizer: 第18回神経科学の基礎と臨床
  • Place of Presentation: 大阪
  • Year and Date: 2008-12-13
• [Presentation] 代謝型グルタミン酸受容体遺伝子とうつ病の発症脆弱性・治療反応性との関連 (2008)
  • Author(s): 功刀浩, 他
  • Organizer: 第41回精神神経系薬物治療研究報告会
  • Place of Presentation: 大阪
  • Year and Date: 2008-12-05
• [Presentation] PACAP欠損マウスの精神・神経機能変化に対するADHD 治療薬アトモキセチンの改善作用 (2008)
  • Author(s): 芝崎 康宏, 他
  • Organizer: ファーマ・バイオフォーラム2008
  • Place of Presentation: 東京
  • Year and Date: 2008-11-29
• [Presentation] 多能性幹細胞からのセロトニン神経細胞の分化誘導 (2008)
  • Author(s): 高井 良宏, 他
  • Organizer: 第114回日本薬理学会近畿部会
  • Place of Presentation: 神戸
  • Year and Date: 2008-11-14
• [Presentation] PC12細胞のNGF誘発神経突起伸展に対するプロスタグランジンCRTH2受容体作用薬の促進効果 (2008)
  • Author(s): 柴田 憲広, 他
  • Organizer: 第114回日本薬理学会近畿部会
  • Place of Presentation: 神戸
  • Year and Date: 2008-11-14
• [Presentation] PACAP遺伝子欠損マウスにおけるストレス受容の障害 (2008)
  • Author(s): 齋田 洋子, 他
  • Organizer: 第113回目本薬理学会近畿部会
  • Place of Presentation: 岡山
  • Year and Date: 2008-06-20
• [Presentation] ラット膵腺房細胞AR42JのRegIIIβ発現に対する神経ペプチドPACAPの作用 (2008)
  • Author(s): 桜井 佑介, 他
  • Organizer: 第113回日本薬理学会近畿部会
  • Place of Presentation: 岡山
  • Year and Date: 2008-06-20
• [Presentation] PACAP欠損マウスのPPI 障害および新奇物体記憶障害に対するADHD治療薬の作用解析 (2008)
  • Author(s): 芝崎 康宏, 他
  • Organizer: 第113回日本薬理学会近畿部会
  • Place of Presentation: 岡山
  • Year and Date: 2008-06-20
• [Presentation] 微小組織特異的網羅的遺伝子発現解析による神経ペプチドPACAPの標的分子同定 (2008)
  • Author(s): 新谷紀人
  • Organizer: 日本薬学会128年会
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-26
• [Presentation] PACAP遺伝子欠損マウスにおける非視覚光受容反応の障害 (2008)
  • Author(s): 畑中道賢
  • Organizer: 第81回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-18
• [Presentation] 概日リズムの光誘発性位相前進に特異的な新規シグナル系の同定 (2008)
  • Author(s): 中村玲子
  • Organizer: 第81回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-18
• [Presentation] Roles of a neuropeptide, PACAP, on psychomotor function and photoentrainment (2008)
  • Author(s): Baba A
  • Organizer: The 60th Annual meeting of the Korean Society of Pharmacology
  • Place of Presentation: 釜山, 韓国
• [Presentation] PACAP Signaling: A promising drug target for neuropsychological disorders (2008)
  • Author(s): Hashimoto H
  • Organizer: Ehrlich II ? 2nd World Conference on Magic Bullets
  • Place of Presentation: Nurnberg, Germany
• [Presentation] Pituitary adenylate cyclase - activating polypeptide (PACAP) : A new risk factor for neuropsychiatric disorders (2008)
  • Author(s): Hashimoto H, et al.
  • Organizer: The 47th ACNP (American College of Neuropsychopharmacology)Annual Meeting
  • Place of Presentation: Arizona, USA
• [Presentation] Serotonin 1A receptor signaling is implicated in the antihyperkinetic effects of attention-deficit hyperactivity disorder (ADHD)medications (2008)
  • Author(s): Tsuchida R, et al.
  • Organizer: Neuroscience 2008
  • Place of Presentation: Washington DC, USA
• [Presentation] Hyperplasia-associated gene of beta cell (HPGB) : a novel protein regulating the mitochondrial functions and morphology (2008)
  • Author(s): Ikeda K, et al.
  • Organizer: The 19th Korea-Japan Joint Seminor on Pharmacology
  • Place of Presentation: 釜山, 韓国
• [Presentation] Altered stress response in PACAP-deficient mice (2008)
  • Author(s): 新谷 紀人, 他
  • Organizer: 第38回日本神経精神薬理学会
  • Place of Presentation: 品川
• [Presentation] Prostanoid CRTH2 receptor signaling regulates light-induced phase advance of circadian rhythm (2008)
  • Author(s): 新谷 紀人, 他
  • Organizer: 第51回神経化学会
  • Place of Presentation: 富山
• [Presentation] Central PACAP plays a stimulatory role in the stress-induced HPA-axis response (2008)
  • Author(s): 新谷 紀人, 他
  • Organizer: 第51回神経化学会
  • Place of Presentation: 富山
• [Presentation] Serotonin 1A receptor is involved in the "paradoxical" antihyperkinetic effect of the drugs treating ADHD (2008)
  • Author(s): 土田 理恵, 他
  • Organizer: 第51回神経化学会
  • Place of Presentation: 富山
• [Presentation] A new method to generate serotonergic neurons from ES cells (2008)
  • Author(s): 嶋田 健, 他
  • Organizer: 第51回神経化学会
  • Place of Presentation: 富山
• [Presentation] Effects of intracerebroventricular injection of prostanoid CRTH2 receptor agonists on the open-field behavior in mice (2008)
  • Author(s): 羽場 亮太, 他
  • Organizer: 第51回神経化学会
  • Place of Presentation: 富山
• [Presentation] Effects of environmental factors on behavioral abnormalities in PACAP-KO mice (2008)
  • Author(s): 石濱 壽紘, 他
  • Organizer: 第51回神経化学会
  • Place of Presentation: 富山
• [Presentation] Involvement of serotonin 1A receptors in antihyperkinetic effect of attention-deficit hyperactivity disorder (ADHD)drugs (2008)
  • Author(s): Tsuchida R, et al.
  • Organizer: The 4^<th> Seoul-Kyoto-Osaka Joint Symposium on Pharmaceutical Sciences for Young Scientists
  • Place of Presentation: Kyoto, Japan
• [Presentation] The roles of PACAP in non-visual photoreception (2008)
  • Author(s): Hatanaka M, et al.
  • Organizer: The 4^<th> Seoul-Kyoto-Osaka Joint Symposium on Pharmaceutical Sciences for Young Scientists
  • Place of Presentation: Kyoto, Japan
• [Presentation] マウス涙腺組織におけるPACAP/PAC1受容体の分布局在と機能解析 (2008)
  • Author(s): 中町智哉, 他
  • Organizer: 第33回日本比較内分泌大会
  • Place of Presentation: 広島
• [Presentation] 脳内における摂食調節-その機構解明と臨床応用について- (2008)
  • Author(s): 塩田清二, 他
  • Organizer: 第33回日本比較内分泌大会
  • Place of Presentation: 広島
• [Presentation] Pituitaly adenylate cyclase-activating polypeptide (PACAP)stimulates proliferation of reactive astrocyte in vitro. (2008)
  • Author(s): Nakamachi T, et al.
  • Organizer: The 38th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: Washington, DC
• [Presentation] Neuroprotective effect of PACAP and the mechanisms : therapeuticeffects in Stroke models. (2008)
  • Author(s): Nakamachi T, et al.
  • Organizer: Showa University International Symposium for Life Science 5th Annual Meeting New Frontiers in Neuroscience : Transmitters/modulators in Health and Disease
  • Place of Presentation: 東京
• [Presentation] 下垂体アデニル酸シクラーゼ活性化ポリペプチド(PACAP)の神経幹細胞に対する作用 (2008)
  • Author(s): 中町智哉, 他
  • Organizer: 第35回日本神経内分泌学会・第23回日本下垂体研究会合同学術集会
  • Place of Presentation: 東京
• [Presentation] 肥満研究のパイオニアたち、そして今 (2008)
  • Author(s): 矢田俊彦
  • Organizer: 第29回日本肥満学会, 特別シンポジウム
  • Place of Presentation: 大分
• [Presentation] 非肥満2型糖尿病モデルGKラットにおける過食病態 (2008)
  • Author(s): 安藤明彦, 他
  • Organizer: 第81回日本内分泌学会学術総会
  • Place of Presentation: 青森
• [Presentation] Dysbindin : pathological clue for developing schizophrenia (2008)
  • Author(s): Hashimoto R
  • Organizer: XIV World Congress on Psychiatric Genetics
  • Place of Presentation: Osaka, Japan
• [Presentation] Gene to behavior pathway in schizophrenia : Progress in schizophrenia research in Japan (CREST) (2008)
  • Author(s): Iwata N, et al.
  • Organizer: XIV World Congress on Psychiatric Genetics
  • Place of Presentation: Osaka, Japan
• [Presentation] Studying candidate genes of lithium response in the Japanese population (2008)
  • Author(s): Hashimoto R, et al.
  • Organizer: XIV World Congress on Psychiatric Genetics
  • Place of Presentation: Osaka, Japan
• [Presentation] Translational research in mental disorder (2008)
  • Author(s): Hashimoto R
  • Organizer: The 51st Annual Meeting of the Japanese Society for Neurochemistry
  • Place of Presentation: Toyama, Japan
• [Presentation] Identification of susceptibility genes for schizophrenia using intermediate phenotype (2008)
  • Author(s): Hashimoto R, et al.
  • Organizer: The 51st Annual Meeting of the Japanese Society for Neurochemistry
  • Place of Presentation: Toyama, Japan
• [Presentation] PACAP Signaling: A promising drug target for neuropsychological disorders (2008)
  • Author(s): Hashimoto H
  • Organizer: Ehrlich II-2nd World Confbrence on Magic Bullets
  • Place of Presentation: Nurnberg, Germany
• [Presentation] Roles of a neuropeptide, PACAP, on psychomotor function and photoentrainment (2008)
  • Author(s): Baba A
  • Organizer: The 19th Korea-Japan Joint Seminor on Pharmacology, The 60th Annual meeting of the Korean Society of Pharmacology
  • Place of Presentation: 釜山, 韓国
• [Presentation] Neuropeptide PACAP is involved in certain types of light-induced physiological responses (2008)
  • Author(s): Hatanaka M
  • Organizer: The 19th Korea-Japan Joint Seminor on Pharmacology
  • Place of Presentation: 釜山, 韓国
• [Presentation] II型糖尿病病態下におけるPACAP-RegIIIβシグナルによる膵β細胞機能制御 (2007)
  • Author(s): 新谷紀人
  • Organizer: 次世代を担う若手医療科学シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2007-12-16
• [Presentation] 神経ペプチドPACAPによる膵β細胞機能調節 (2007)
  • Author(s): 新谷紀人
  • Organizer: 第35回薬物活性シンポジウム
  • Place of Presentation: 広島
  • Year and Date: 2007-11-29
• [Presentation] セルレイン誘発性急性膵炎におけるPACAPの役割 (2007)
  • Author(s): 桜井佑介
  • Organizer: 第112回日本薬理学会近畿部会
  • Place of Presentation: 大阪
  • Year and Date: 2007-11-16
• [Presentation] 新規因子Hyperplasia-associated gene of beta cell (HPGB)によるミーコンドリア機能制御 (2007)
  • Author(s): 北村和之
  • Organizer: 第112回日本薬理学会近畿部会
  • Place of Presentation: 大阪
  • Year and Date: 2007-11-16
• [Presentation] 種々のADHD治療薬と5-HT_<1A>受容体アゴニストの併用投与による自発運動抑制作用 (2007)
  • Author(s): 久保勝裕
  • Organizer: 第112回日本薬理学会近畿部会
  • Place of Presentation: 大阪
  • Year and Date: 2007-11-16
• [Presentation] PACAP-regulated BETA-CELL PROLIFERATION: Implication of RegIIIBETA (2007)
  • Author(s): K Hamagami
  • Organizer: 8th International Symposium for VIP, PACAP and Related Peptides
  • Place of Presentation: Manchester, Vermont, USA
  • Year and Date: 2007-09-05
• [Presentation] Evidence that the PACAP gene contributes to the risk of schizophrenia, 8th International Symposium for VIP (2007)
  • Author(s): Hitoshi Hashimoto
  • Organizer: PACAP and Related Peptides
  • Place of Presentation: Manchester, Vermont, USA
  • Year and Date: 2007-09-05
• [Presentation] PACAP-REGULATED BETA-CELL PROLIFERATION: IMPLICATION OF RegIIIBETA (2007)
  • Author(s): K Hamagami
  • Organizer: 8th International Symposium for VIP, PACAP and Related Peptides
  • Place of Presentation: Manchester, Vermont, USA
  • Year and Date: 2007-09-05
• [Presentation] Neuroprotective mechanism of PACAP associated with IL-6 signaling (2007)
  • Author(s): Tomoya Nakamachi
  • Organizer: 8th International Symposium for VIP, PACAP and Related Peptides
  • Place of Presentation: Manchester, Vermont, USA
  • Year and Date: 2007-09-05
• [Presentation] EVIDENCE THAT THE PACAP GENE CONTRIBUTES TO THE RISK OF SCHIZOPHRENIA (2007)
  • Author(s): Hitoshi Hashimoto
  • Organizer: 8th International Symposium for VIP, PACAP and Related Peptides
  • Place of Presentation: Manchester, Vermont, USA
  • Year and Date: 2007-09-05
• [Presentation] 大阪大学における統合失調症外来について (2007)
  • Author(s): 橋本亮太
  • Organizer: 第3回大阪北部精神科症例検討会
  • Place of Presentation: 大阪
  • Year and Date: 2007-07-25
• [Presentation] 統合失調症の分子病態と神経ペプチドPACAP (2007)
  • Author(s): 新谷紀人
  • Organizer: 第29回日本生物学的精神医学会・第37回日本神経精神薬理学会合同年会
  • Place of Presentation: 札幌
  • Year and Date: 2007-07-11
• [Presentation] PACAP遺伝子欠損マウスの異常行動発現における環境因子の役割 (2007)
  • Author(s): 石濱壽紘
  • Organizer: 第29回日本生物学的精神医学会・第37回日本神経精神薬理学会合同年会
  • Place of Presentation: 札幌
  • Year and Date: 2007-07-11
• [Presentation] 第二世代抗精神病薬と認知機能との関連について-リスペリドンと他剤との比較- (2007)
  • Author(s): 橋本亮太
  • Organizer: 第3回大阪中央精神科症例検討会
  • Place of Presentation: 大阪
  • Year and Date: 2007-07-05
• [Presentation] Hyperplasia-associated gene of beta cell(HPGB)の機能解析 (2007)
  • Author(s): 池田和哉
  • Organizer: 第111回日本薬理学会近畿部会
  • Place of Presentation: 名古屋
  • Year and Date: 2007-06-15
• [Presentation] 膵b細胞増殖、インスリン分泌能におけるPACAP-RegIIIbシグナルの役割 (2007)
  • Author(s): 楠本慶介
  • Organizer: 第111回日本薬理学会近畿部会
  • Place of Presentation: 名古屋
  • Year and Date: 2007-06-15
• [Presentation] 中間表現型と遺伝子 (2007)
  • Author(s): 橋本亮太
  • Organizer: 第6回Schizophrenia研究会
  • Place of Presentation: 高知
  • Year and Date: 2007-05-19
• [Presentation] Serotonin 1A (5-HT1A) agonist decreases locomotor activity and prefrontal neuronal activation in amphetamine treated mice (2007)
  • Author(s): Rie Tsuchida
  • Organizer: Neuro2007
  • Place of Presentation: Yokohana, Japan
• [Presentation] ES細胞からの新規神経細胞分化誘導系の確立 (2007)
  • Author(s): 嶋田健
  • Organizer: ファーマバイオフォーラム2007
  • Place of Presentation: 大阪
• [Presentation] 新規機能未知遺伝子HPGBのミトコンドリアにおける機能解析 (2007)
  • Author(s): 池田和哉
  • Organizer: ファーマバイオフォーラム2007
  • Place of Presentation: 大阪
• [Presentation] Involvement of environmental factors in the expression of psychomotor abnormalities in PACAP knock-out mice (2007)
  • Author(s): Toshihiro Ishihama
  • Organizer: Neuro2007
  • Place of Presentation: Yokohana, Japan
• [Presentation] Translational Research for Schizophrenia (2007)
  • Author(s): Hashimoto R
  • Organizer: 4^<th> Japanese-German Frontiers of Science Symposium
  • Place of Presentation: Shonan, Japan
• [Presentation] Genetic variations in the dysbindin gene are associated with human memory performance (2007)
  • Author(s): Hashimoto R
  • Organizer: IPA 2007 Osaka Silver Congress
  • Place of Presentation: Osaka
• [Presentation] 統合失調症脆弱性遺伝子ディスバインジンの遺伝子改変動物による分子病態研究 (2007)
  • Author(s): 橋本亮太
  • Organizer: 統合脳5領域「平成19年度 冬の合同班会議」
  • Place of Presentation: 東京
• [Presentation] PACAP遺伝子は統合失調症と関連する (2007)
  • Author(s): 橋本亮太
  • Organizer: 第50回日本神経化学会・第30回日本神経科学学会・第17回日本神経回路学会合同年会
  • Place of Presentation: 横浜
• [Presentation] 神経ペプチドであるPACAPと統合失調症の関連:脳構造、記憶、抗精神病薬を用いた統合的解析 (2007)
  • Author(s): 橋本亮太
  • Organizer: 統合脳5領域「平成19年度 夏の合同班会議」
  • Place of Presentation: 札幌
• [Presentation] 統合失調症脆弱性遺伝子であるディスバインジン欠損マウスにおける異常行動 (2007)
  • Author(s): 橋本亮太
  • Organizer: 第29回日本生物学的精神医学会・第37回日本神経精神薬理学会合同年会
  • Place of Presentation: 札幌
• [Presentation] DISC1遺伝子Ser704Cys機能多型はうつ病のリスク、ヒトの脳構造、神経細胞保護に影響を与える (2007)
  • Author(s): 橋本亮太
  • Organizer: 第29回日本生物学的精神医学会・第37回日本神経精神薬理学会合同年会
  • Place of Presentation: 札幌
• [Presentation] 統合失調症脆弱性遺伝子ディスバインジンによる統合失調症の病態解明研究 (2007)
  • Author(s): 橋本亮太
  • Organizer: 第103回日本精神神経学会総会
  • Place of Presentation: 高知
• [Presentation] マウス脳におけるADNPとPACAP特異的受容体の分布・局在 (2007)
  • Author(s): 中町智哉
  • Organizer: 第4回GPCR研究会
  • Place of Presentation: 東京
• [Presentation] Functional significance of PACAP on neuroprotection and neurodevelopment (2007)
  • Author(s): Seiji Shioda
  • Organizer: 8th International Symposium for VIP, PACAP and Related Peptides
  • Place of Presentation: Manchester, VT, USA
• [Presentation] Distribution of activity-dependent neuroprotective protein (ADNP) and (PACAP) type 1 receptor (PAC1R) in the mouse brain (2007)
  • Author(s): Tomoya Nakamachi
  • Organizer: 8th International Symposium for VIP, PACAP and Related Peptides
  • Place of Presentation: Manchester, VT, USA
• [Presentation] THE ROLE OF PACAP IN ASTROGLISL DIFFERENTIATION IN VIVO AND IN VITRO (2007)
  • Author(s): Jun Watanabe
  • Organizer: 8th International Symposium for VIP, PACAP and Related Peptides
  • Place of Presentation: Manchester, VT, USA
• [Presentation] Effect of PACAP on neuronal progenitor cells in vivo (2007)
  • Author(s): Daisuke Hayashi
  • Organizer: 8th International Symposium for VIP, PACAP and Related Peptides
  • Place of Presentation: Manchester, VT, USA
• [Presentation] THE ROLE OF PACAP IN ASTROGLIAL DIFFERENTIATION IN VIVO AND IN VITRO (2007)
  • Author(s): Jun Watanabe
  • Organizer: 8th International Symposium for VIP, PACAP and Related Peptides
  • Place of Presentation: Manchester, VT, USA
• [Presentation] 成体神経幹細胞に対する下垂体アデニル酸シクラーゼ活性化ポリペプチド(PACAP)の作用 (2007)
  • Author(s): 中町智哉
  • Organizer: 第32回日本比較内分泌学会大会
  • Place of Presentation: 東京
• [Presentation] in vitro及びin vivoにおけるPACAPの神経幹細胞に対するアストロサイト分化誘導作用 (2007)
  • Author(s): 渡邊潤
  • Organizer: 第32回日本比較内分泌学会大会
  • Place of Presentation: 東京
• [Presentation] Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Attenuates Focal Cerebral Ischemic Injury via Bcl-2 and IL-6 Signaling (2007)
  • Author(s): Tomoya Nakamachi
  • Organizer: The 37th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: San Diego, CA, USA
• [Presentation] Involvement of beta isoform of protein kinase C in the PACAP-induced differentiation of neural stem cells into astrocytes (2007)
  • Author(s): Jun Watanabe
  • Organizer: The 37th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: San Diego, CA, USA
• [Presentation] PACAP deficient mice exhibit light parameter dependent abnormalities of nonvisual photoreception (2007)
  • Author(s): Yasushi Isojima
  • Organizer: Neuro2007
  • Place of Presentation: Yokohana, Japan
• [Presentation] Altered non-visual photoreceptive response in PACAP-knockout mice (2006)
  • Author(s): Shintani N
  • Organizer: The 16th International Symposium on Regulatory Peptides (REGPEP'06)【国際学会】
  • Place of Presentation: 箱根
• [Book] Transmitters and Modulators in Health and Disease -New Frontiers in Neuroscience, Expression and localization of pituitary adenylate cyclase-activating polypeptide (PACAP) specific receptor (PAC1R) after traumatic brain injury in mice (2009)
  • Author(s): Morikawa K, et al.
  • Publisher: Springer-Verlag, Tokyo
• [Book] Expression and localization of pituitary adenylate cyclase-activating polypeptide (PACAP) specific receptor (PAC1R)after traumatic brain injury in mice (2009)
  • Author(s): Morikawa K, et al.
  • Publisher: Springer-Verlag, Tokyo, Transmitters and Modulators in Health and Disease New Frontiers in Neuroscience (in press)
• [Book] Increased behavioral activity with regular circadian rhythm in PACAP specific receptor (PAC1)transgenic mice (2009)
  • Author(s): Arata T, et al.
  • Publisher: Springer-Verlag, Tokyo, Transmitters and Modulators in Health and Disease-New Frontiers in Neuroscience (in press)
• [Book] インスリン分泌のCa2+チャンネル機構、In 新時代の糖尿病学(1)、日本臨床増刊号66巻 (2008)
  • Author(s): 加計正文, 他
  • Publisher: 日本臨床社
• [Book] 神経ペプチドPACAP-新しい創薬標的分子探索へ, 遺伝子医学MOOK(8) (2007)
  • Author(s): 馬場 明道 他
• [Book] New Frontiers in regenerative Medicine (2007)
  • Author(s): Nakajo, S., et. al.
  • Total Pages: 146
  • Publisher: Springer-Verlag
• [Book] New Frontiers in regenerative Medicine (2007)
  • Author(s): Ohtaki, H., et. al.
  • Total Pages: 146
  • Publisher: Springer-Verlag
• [Book] ジョスリン糖尿病学 第2版 (2007)
  • Author(s): 矢田俊彦, ほか
  • Total Pages: 1345
  • Publisher: メディカル・サイエンス・インターナショナル
• [Book] Breathing, Feeding, and Neurodegeneration. (2006)
  • Author(s): Watanabe, J., et. al.
  • Total Pages: 146
  • Publisher: Springer-Verlag
• [Remarks] ホームページ等
  • URL: http://www.phs.osaka-u.ac.jp/homepage/b010/index.html
• [Remarks]
  • URL: http://www.med.osaka-u.ac.jp/pub/psy/www/jp/labo/sp/index.htm
• [Remarks]
  • URL: http://www10.showa-u.ac.jp/?anat-1/index.html
• [Remarks]
  • URL: http://www.phs.osaka-u.ac.jp/homepage/b10/index.html
• [Remarks]
  • URL: http://www.med.osaka-u.ac.jp/pub/psy/www/jp/labo/sp/index.htm
• [Remarks]
  • URL: http://www.phs.osaka-u.ac.jp/homepage/b010/index.html
• [Remarks]
  • URL: http://www.med.osaka-u.ac.jp/pub/psy/www/jp/labo/sp/index.htm
• [Remarks]
  • URL: http://www10.showa-u.ac.jp/~anat-1/index.html
• [Patent(Industrial Property Rights)] 精神障害治療用の薬学的組成物およびそのスクリーニング方法 (2006)
  • Inventor(s): 馬場明道、川口ちひろ、橋本均、新谷紀人、永井克也、礒島康史、杉本幸彦
  • Industrial Property Rights Holder: 大阪大学
  • Industrial Property Number: 2006-356120
  • Filing Date: 2006-12-28
• [Patent(Industrial Property Rights)] 精神障害治療用の薬学的組成物およびそのスクリーニング方法 (2006)
  • Inventor(s): 馬場明道, ほか7名
  • Industrial Property Rights Holder: 大阪大学
  • Industrial Property Number: 2006-356120
  • Filing Date: 2006-12-28