| Project/Area Number |
18209026
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
TANAKA Yoshiya University of Occupational and Environmental Health, Japan, 医学部, 教授 (30248562)
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| Co-Investigator(Kenkyū-buntansha) |
UETA Youiti 産業医科大学, 医学部, 教授 (10232745)
KOUNO Kimitoshi 産業医科大学, 医学部, 教授 (00153479)
TOKURA Yoshiki 産業医科大学, 医学部, 教授 (00172156)
NAKAMURA Toshitaka 産業医科大学, 医学部, 教授 (50082235)
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| Project Period (FY) |
2006 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥49,140,000 (Direct Cost: ¥37,800,000、Indirect Cost: ¥11,340,000)
Fiscal Year 2009: ¥12,090,000 (Direct Cost: ¥9,300,000、Indirect Cost: ¥2,790,000)
Fiscal Year 2008: ¥12,090,000 (Direct Cost: ¥9,300,000、Indirect Cost: ¥2,790,000)
Fiscal Year 2007: ¥12,090,000 (Direct Cost: ¥9,300,000、Indirect Cost: ¥2,790,000)
Fiscal Year 2006: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000)
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| Keywords | ストレス科学 / デンドライト / 樹状細胞 / 神経ペプチド / ランゲルハンス細胞 / 免疫系 / アポトーシス / 酸化ストレス / ホメオサーベイランス |
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| Research Abstract |
"Dendrite" is expressed on various cells including neuron in CNS and periphery, dendritic cells in immune system, Langerhans cells in skin, osteocyte in bone and so on. The dendrite receives multiple stresses and functions as stress-surveillance sensors. The cells possessing the dendrite receive stress-stimulation, transform it to multiple intracellular signals through nucleic transcription and transduce the signals to various defensive cellular functions in central nerve, immune, skin, metabolic systems in human body. Thus, we postulate that the dendrite plays a pivotal role in the self-defense system through initiating multiple stress-stimulation as a central sensor.
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