• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Mechanism for inflammation-associated gastrointestinal carcinogenesis.

Research Project

Project/Area Number 18209027
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionKyoto University

Principal Investigator

CHIBA Tsutomu  Kyoto University, 医学研究科, 教授 (30188487)

Co-Investigator(Kenkyū-buntansha) 渡部 則彦  京都大学, 医学研究科, 准教授 (50419446)
Co-Investigator(Renkei-kenkyūsha) WATANABE Norihiko  京都大学, 医学研究科, 准教授 (50419446)
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥48,360,000 (Direct Cost: ¥37,200,000、Indirect Cost: ¥11,160,000)
Fiscal Year 2008: ¥12,090,000 (Direct Cost: ¥9,300,000、Indirect Cost: ¥2,790,000)
Fiscal Year 2007: ¥11,830,000 (Direct Cost: ¥9,100,000、Indirect Cost: ¥2,730,000)
Fiscal Year 2006: ¥24,440,000 (Direct Cost: ¥18,800,000、Indirect Cost: ¥5,640,000)
KeywordsAID / 炎症 / 発癌 / 遺伝子変異 / H. pylori / REG蛋白 / 染色体不安定性 / reg蛋白 / STAT3 / IFNγ / NFκB / タイプ4分泌装置 / H.pylori / 潰瘍性大腸炎 / Activation-induced cytidine deaminase(AID) / P53
Research Abstract

炎症から消化器発癌に至る機序について研究を行い、HPからの胃癌発症では、ホストのTh1/Th2バランスが重要であり、IFNγ, IL6, 22などがregIαの発現を増強して発癌に関与していること、胃炎、胃癌の発症には小腸パイエル板が必須であること、さらにHPが胃粘膜でAIDの発現を誘導して遺伝子変異を誘導することが明らかとなった。さらにColitic cancerについては、潰瘍性大腸炎における種々のサイトカインがAIDの発現を増強して遺伝子変異を導入し、発癌に寄与していると考えられた。

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (89 results)

All 2009 2008 2007 2006

All Journal Article (66 results) (of which Peer Reviewed: 21 results) Presentation (23 results)

  • [Journal Article] A novel mouse model of hepatocarcinogenesis triggered by AID causing deleterious p53 mutations2009

    • Author(s)
      Takai A, Toyoshima T, Uemura M, Kitawaki Y, Marusawa H, Hiai H, Yamada S, Okazaki I, Honjo T, Chiba T, Kinoshita K
    • Journal Title

      Oncogene 28

    • Related Report
      2008 Final Research Report
  • [Journal Article] Small intestine Peyer's patches are major induction sites of the Helicobacter-induced host immune responses2008

    • Author(s)
      Watanabe N, Kiriya K, Chiba T
    • Journal Title

      Gastroenterology 134

      Pages: 642-643

    • Related Report
      2008 Final Research Report
  • [Journal Article] Activation-induced cytidine deaminase links bile duct inflammation to human cholangiocarcinoma2008

    • Author(s)
      Komori J, Marusawa H, Machimoto T, Endo Y, Kinoshita K, Kou T, Haga H, Ikai I, Uemoto S, Chiba T
    • Journal Title

      Hepatology 47

      Pages: 888-896

    • Related Report
      2008 Final Research Report
  • [Journal Article] REG I α Protein Mediates an Anti-apoptotic Effect of STAT3 Signaling in Gastric Cancer Cells2008

    • Author(s)
      Sekikawa A, Fukui H, Fujii S, Ichikawa K, Tomita S, Imura J, Chiba T, Fujimori T
    • Journal Title

      Carcinogenesis 29

      Pages: 76-83

    • Related Report
      2008 Final Research Report
  • [Journal Article] Coiled-coil domain containing 85B suppresses the β-catenin activity in a p53-dependent manner2008

    • Author(s)
      Iwai A, Hijikata M, Hishiki T, Isono O, Chiba T, Shimotohno K
    • Journal Title

      Oncogene 27

      Pages: 1520-1526

    • Related Report
      2008 Final Research Report
  • [Journal Article] Fatal autoimmune hepatitis induced by concurrent loss of naturally arising regulatory T cells and PD-1-mediated signaling2008

    • Author(s)
      Kido M, Watanabe N, Okazaki T, Akamatsu T, Saga K, Nishio A, Tanaka J, Honjo T, Chiba T
    • Journal Title

      Gastroenterology 135

      Pages: 1333-1343

    • Related Report
      2008 Final Research Report
  • [Journal Article] Activation-induced cytidine deaminase links between inflammation to colitis-associated colorectal cancers2008

    • Author(s)
      Endo Y, Marusawa H, Kou T, Nakase H, Fujii S, Fujimori T, Kinoshita K, Honjo T, Chiba T
    • Journal Title

      Gastroenterology 135

      Pages: 889-898

    • Related Report
      2008 Final Research Report
  • [Journal Article] Organ-specific profiles of genetic changes in cancers caused by activation-induced cytidine deaminase expression2008

    • Author(s)
      Morisawa T, Marusawa H, Ueda Y, Iwai A, Okazaki IM, Honjo T, Chiba T
    • Journal Title

      Int J Cancer 123

      Pages: 2735-40

    • Related Report
      2008 Final Research Report
  • [Journal Article] Mechanism for gastric cancer development by Helicobacter pylori ifection2008

    • Author(s)
      Chiba T, Marusawa H, Seno H, Watanabe N
    • Journal Title

      J Gastroenterol Hepatol 23

      Pages: 1175-1181

    • Related Report
      2008 Final Research Report
  • [Journal Article] Helicobacter pylori immunology and vaccine2008

    • Author(s)
      Vorobjova T, Watanabe T, Chiba T
    • Journal Title

      Helicobacter 13(Suppl 1)

      Pages: 18-22

    • Related Report
      2008 Final Research Report
  • [Journal Article] Small intestine Peyer's patches are major induction sites of the Helicobacter-induced host immune responses.2008

    • Author(s)
      Watanabe N, Kiriya K, Chiba T
    • Journal Title

      Gastroenterology 134

      Pages: 642-643

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation-induced cytidine deaminase links bile duct inflammation to human cholangiocarcinoma.2008

    • Author(s)
      Komori J, Marusawa H, Chiba T, et al.
    • Journal Title

      Hepatology 47

      Pages: 888-896

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] REG Iα Protein Mediates an Anti-apoptotic Effect of STAT3 Signaling in Gastric Cancer Cells.2008

    • Author(s)
      Sekikawa A, Fukui H, Fujii S, Ichikawa K, Tomita S, Imura J, Chiba T, Fujimori T
    • Journal Title

      Carcinogenesis 29

      Pages: 76-83

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Coiled-coil domain containing 85B suppresses the β-catemin activity in a p53-dependent manner.2008

    • Author(s)
      Iwai A, Hijikata M, Hishiki T, Isono O, Chiba T, Shimotohno K
    • Journal Title

      Oncogene 27

      Pages: 1520-1526

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fatal autoimmune hepatitis induced by concurrent loss of naturally arising regulatory T cells and PD-1-mediated signaling.2008

    • Author(s)
      Kido M, Watanabe N, Okazaki T, Akamatsu T, Saga K, Nishio A, Tanaka J, Honjo T, Chiba T
    • Journal Title

      Gastroenterology 135

      Pages: 1333-1343

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation-induced cytidine deaminase links between inflammation to colitis-associated colorectal cancers.2008

    • Author(s)
      Endo Y, Marusawa H, Kou T, Nakase H, Fujii S, Fujimori T, Kinoshita K, Honjo T, Chiba T
    • Journal Title

      Gastroenterology 135

      Pages: 889-898

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Organ-specific profiles of genetic changes in cancers caused by activation-induced cytidine deaminase expression.2008

    • Author(s)
      Morisawa T, Marusawa H, Ueda Y, Iwai A, Okazaki IM, Honjo T, Chiba T
    • Journal Title

      Int J Cancer 123

      Pages: 1175-1181

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechanism for gastric cancer development by Helicobacter pylori in fection.2008

    • Author(s)
      Chiba T, Marusawa H, Seno H, Watanabe N
    • Journal Title

      J Gastroenterol Hepatol 23

      Pages: 1175-1181

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Helicobacter pylori immunology and vaccine.2008

    • Author(s)
      Vorobjova T, Watanabe T, Chiba T
    • Journal Title

      Helicobacter 13

      Pages: 18-22

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel mouse model of hepatocarcinogenesis triggered by AID causing deleterious p53 mutations.2008

    • Author(s)
      Takai A, Toyoshima T, Uemura M, Kitawaki Y, Marusawa H, Hiai H, Yamada S, Okazaki I, Honjo T, Chiba T, Kinoshita K
    • Journal Title

      Oncogene 28

      Pages: 469-478

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of the REG IV gene in ulcerative colitis2007

    • Author(s)
      Nanakin A, Fukui H, Fujii S, Sekikawa A, Kanda N, Hisatsune H, Seno H, Konda Y, Fujimori T, Chiba T.
    • Journal Title

      Lab Invest 87

      Pages: 304-314

    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Journal Article] Growth arrest-specific gene 6 and Axl signaling enhances gastric cancer cell survival via Akt pathway2007

    • Author(s)
      Sawabu T, Seno H, Kawashima T, Fukuda A, Uenoyama Y, Kawada M, Kanda N, Sekikawa A, Fukui H, Yanagita M, Yoshibayashi H, Satoh S, Sakai Y, Nakano T, Chiba T.
    • Journal Title

      Mol Carcinogenesis 46

      Pages: 155-164

    • Related Report
      2008 Final Research Report
  • [Journal Article] Expression of activation-induced cytidine deaminase in human hepatocytes during hepatocarcinogenesis2007

    • Author(s)
      Kou T, Marusawa H, Kinoshita K, Endo Y, Okazaki IM, Ueda Y, Kodama Y, Haga H, Ikai I, Chiba T
    • Journal Title

      Int J Cancer 120

      Pages: 469-476

    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Journal Article] Essential role of Peyer's patches in the development of Helicobacter-induced gastritis2007

    • Author(s)
      Kiriya K, Watanabe N, Nishio A, Okazaki K, Kido M, Saga K, Tanaka J, Akamatsu T, Ohashi S, Asada M, Fukui T, Chiba T
    • Journal Title

      Int Immunol 19

      Pages: 435-446

    • NAID

      10020110345

    • Related Report
      2008 Final Research Report
  • [Journal Article] Glycosylation and palmitoylation of Wnt-3a are coupled to produce an active form of Wnt-3a2007

    • Author(s)
      Komekado H, Yamamoto H, Chiba T, Kikuchi A
    • Journal Title

      Genes Cells 12

      Pages: 521-534

    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Journal Article] Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium2007

    • Author(s)
      Matsumoto Y, Marusawa H, Kinoshita K, Endo Y, Kou T, Morisawa T, Azuma T, Okazaki IM, Honjo T, Chiba T
    • Journal Title

      Nat Med 13

      Pages: 470-476

    • Related Report
      2008 Final Research Report
  • [Journal Article] Matrix metalloproteinase-7 triggers the matricrine action of insulin-like growth factor binding protein 2 in the extracellular matrix2007

    • Author(s)
      Miyamoto S, Nakamura M, Yano K, Ishii G, Hasebe T, Endoh Y, Sangai T, Maeda H, Shi-Chuang Z, Chiba T, Ochiai A
    • Journal Title

      Cancer Sci 98

      Pages: 685-691

    • Related Report
      2008 Final Research Report
  • [Journal Article] Strategies for improving outcomes for gastric cancer2007

    • Author(s)
      Chiba T, Aoi T
    • Journal Title

      (Editorials)J Gastroenterol Hepatol 22

      Pages: 965-967

    • Related Report
      2008 Final Research Report
  • [Journal Article] Immunoglobulin VH gene analysis in primary gastric MALT lymphoma2007

    • Author(s)
      Sakuma H, Nakamura T, Uemura N, Chiba T, Sugiyama T, Asaka M, Akamatsu T, Ueda R, Eimoto T, Goto H, Nakamura S, Inagaki H
    • Journal Title

      Modern Pathol 20

      Pages: 460-466

    • Related Report
      2008 Final Research Report
  • [Journal Article] Expression of human activation-induced cytidine deaminase in human hepatocytes via NF-kB signaling2007

    • Author(s)
      Endo Y, Marusawa H, Kinoshita K, Morisawa T, Sakurai T, Okazaki IM, Watashi K, Shimotono K, Honjo T, Chiba T
    • Journal Title

      Oncogene 26

      Pages: 5587-5595

    • Related Report
      2008 Final Research Report
  • [Journal Article] Novel IL4 and IL1RN variations associated with non-cardia gastric cancer in Japan : Comprehensive analysis of 207 polymorphisms of 11 cytokines2007

    • Author(s)
      Seno H, Satoh K, Tsuji S, Shiratsuchi T, Harada Y, Hamajima N, Sugano K, Kawano S, Chiba T
    • Journal Title

      J Gastroenterol Hepatol 22

      Pages: 729-737

    • Related Report
      2008 Final Research Report
  • [Journal Article] Chromosomal instability by β-catenin/TCF trascription in APC or β-catenin mutant cells2007

    • Author(s)
      Aoki K, Aoki M, Sugai M, Harada N, Miyoshi H, Tsukamoto T, Mizoshita T, Tatematsu M, Seno H, Chiba T, Oshima M, Hsieh C-L, Taketo MM
    • Journal Title

      Oncogene 26

      Pages: 3511-3520

    • Related Report
      2008 Final Research Report
  • [Journal Article] Cross-Primed CD8(+) Cytotoxic T cells Induce Severe Helicobacter-associated Gastritis in the Absence of CD4(+) T cells2007

    • Author(s)
      Fukui T, Nishio A, Okazaki K, Kasahara K, Saga K, Tanaka J, Uza N, Ueno S, Kido M, Ohashi S, Asada M, Nakase H, Watanabe N, Chiba T
    • Journal Title

      Helicobacter 12

      Pages: 486-497

    • Related Report
      2008 Final Research Report
  • [Journal Article] Magnified endoscopic view of primary follicular lymphoma at the duodenal papilla2007

    • Author(s)
      Nakase H, Matsuura M, Mikami S, Chiba T
    • Journal Title

      Intern Med 46

      Pages: 141-142

    • NAID

      130000078579

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Growth arrest-specific gene 6 and Axl signaling enhances gastric cancer cell survival via Akt pathway2007

    • Author(s)
      Sawabu T, Seno H, Chiba T, et al.
    • Journal Title

      Mol Carcinogenesis 46

      Pages: 155-164

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Essential role of Peyer's patches in the development of Helicobacter-induced gastritis2007

    • Author(s)
      Kiriya K, Watanabe N, Chiba T, et al.
    • Journal Title

      Int Immunol 19

      Pages: 435-446

    • NAID

      10020110345

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Helicobacter pylori infection triggers aberrant expression of activationinduced cytidine deaminase in gastric epithelium2007

    • Author(s)
      Matsumoto Y, Marusawa H, Chiba T, et al.
    • Journal Title

      Nat Med 13

      Pages: 470-476

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Matrix metalloproteinase-7 triggers the matricrine action of insulin-like growth factor binding protein 2 in the extracellular matrix2007

    • Author(s)
      Miyamoto S, Chiba T, Ochiai A, et al.
    • Journal Title

      Cancer Sci 98

      Pages: 685-691

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Strategies for improving outcomes for gastric cancer. (Editorials)2007

    • Author(s)
      Chiba T, Aoi T
    • Journal Title

      J Gastroenterol Hepatol 22

      Pages: 965-967

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunoglobulin VH gene analysis in primary gastric MALT lymnhoma2007

    • Author(s)
      Sakuma H, Chiba T, Inagaki H, et al.
    • Journal Title

      Modern Pathol 20

      Pages: 460-466

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel IL4 and IL1RN variations associated with non-cardia gastric cancer in Japan: Comprehensive analysis of 207 polymorphisms of 11 cytokines2007

    • Author(s)
      Seno H, Satoh K, Tsuji S, Shiratsuchi T, Harada Y, Hamajima N, Sugano K, Kawano S, Chiba T
    • Journal Title

      J Gastroenterol Hepatol 22

      Pages: 729-737

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chromosomal instability by β-catenin/TCF trascription in APC or β-catenin mutant cells2007

    • Author(s)
      Aoki K, Seno H, Chiba T, Taketo MM, et al.
    • Journal Title

      Oncogene 26

      Pages: 3511-3520

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of human activation-induced cytidine deaminase in human hepatocytes via NF-kB signaling2007

    • Author(s)
      Endo Y, Marusawa H, Chiba T, et al.
    • Journal Title

      Oncogene 26

      Pages: 5587-5595

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cross-Primed CD8(+) Cytotoxic T cells Induce Severe Helicobacterassociated Gastritis in the Absence of CD4(+) T cells2007

    • Author(s)
      Fukui T, Nishio A, Okazaki K, Chiba T, et al.
    • Journal Title

      Helicobacter 12

      Pages: 486-497

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Essential role of Peyer's patches in the development of Helicobacter-induced gastritis.2007

    • Author(s)
      Kiriya K, Watanabe N, Chiba T, et al.
    • Journal Title

      International Immunology 19

      Pages: 435-446

    • NAID

      10020110345

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium.2007

    • Author(s)
      Matsumoto Y, Marusawa H, Honjo T, Chiba T, et al.
    • Journal Title

      Nature Medicine 13

      Pages: 470-476

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Novel IL4 and IL1RN variations associated with non-cardia gastric cancer in Japan : Comprehensive analysis of 207 polymorphisms of 11 cytokines.2007

    • Author(s)
      Seno H, Satoh K, Sugano K, Kawano S, Chiba T, et al.
    • Journal Title

      J Gastroenterol Hepatol 22

      Pages: 729-737

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Expression of the REG IV gene in ulcerative colitis.2007

    • Author(s)
      Nanakin A, Fukui H, Chiba T, et al.
    • Journal Title

      Lab Invest 87

      Pages: 304-314

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Expression of activation-induced cytidine deaminase in human hepatocytes via NF-kB signaling.2007

    • Author(s)
      Endo Y, Marusawa H, Honjo T, Chiba T, et
    • Journal Title

      Oncogene (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Gastric mucosal hyperplasia via up-regulation of gastrin induced by persistent activation of gastric innate immunity in MHC class II-deficient mice2006

    • Author(s)
      Fukui T, Nishio A, Okazaki K, Uza N, Ueno S, Kido M, Inoue S, Kitamura H, Kiriya K, Ohashi S, Asada M, Tamaki H, Matsuura M, Kawasaki K, Suzuki K, Uchida K, Fukui H, Nakase H, Watanabe N, Chiba T
    • Journal Title

      Gut 55

      Pages: 607-615

    • Related Report
      2008 Final Research Report
  • [Journal Article] Involvement of cyclooxygenase-2 in gastric mucosal hypertrophy in gastrin transgenic mice2006

    • Author(s)
      Kanda N, Seno H, Kawada M, Sawabu T, Uenoyama T, Nakajima T, Konda Y, Fukui H, Takeuchi T, Chiba T
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol 290

    • Related Report
      2008 Final Research Report
  • [Journal Article] Risk of subsequent development of gastric cancer in patients with previous gastric epithelial neoplasia2006

    • Author(s)
      Aoi T, Marusawa H, Sato T, Chiba T, Maruyama M
    • Journal Title

      Gut 55

      Pages: 588-589

    • Related Report
      2008 Final Research Report
  • [Journal Article] Hypoxia induced by benign intestinal epithelial cells is associated with cyclooxygenase-2 expression in stromal cells through AP-1-dependent pathway2006

    • Author(s)
      Uenoyama Y, Seno H, Fukuda A, Sekikawa A, Nanakin A, Sawabu T, Kawada M, Kanda N, Suzuki K, Yada N, Fukui H, Chiba T
    • Journal Title

      Oncogene 25

      Pages: 3277-3285

    • Related Report
      2008 Final Research Report
  • [Journal Article] Anti-viral protein APOBEC3G is induced by interferon-alpha stimulation in human hepatocytes2006

    • Author(s)
      Tanaka Y, Marusawa H, Seno H, Matsumoto Y, Ueda Y, Kodama Y, Endo Y, Yamauchi J, Matsumoto T, Takaori-Kondo A, Ikai I, Chiba T
    • Journal Title

      Biochem Biophys Res Commun 341

      Pages: 314-319

    • Related Report
      2008 Final Research Report
  • [Journal Article] Expression of APOBEC2 is transcriptionally regulated by NF-κB in human hepatocytes2006

    • Author(s)
      Matsumoto T, Marusawa H, Endo Y, Ueda Y, Matsumoto Y, Chiba T
    • Journal Title

      FEBS Lett 580

      Pages: 731-735

    • Related Report
      2008 Final Research Report
  • [Journal Article] Host factors are important in determining clinical outcomes of Helicobacter pylori infection2006

    • Author(s)
      Chiba T, Seno H, Marusawa H, Wakatsuki Y, Okazaki K
    • Journal Title

      J Gastroenterol 41

      Pages: 1-9

    • NAID

      10017328156

    • Related Report
      2008 Final Research Report
  • [Journal Article] Signal tranducers of transcription 3 activation is involved in nuclear accumulation of β-catenin in colorectal cancer2006

    • Author(s)
      Kawada M, Seno H, Uenoyama Y, Sawabu T, Kanda N, Fukui H, Shimahara Y, Chiba T
    • Journal Title

      Cancer Res 66

      Pages: 2913-2917

    • Related Report
      2008 Final Research Report
  • [Journal Article] Rapid development of diffuse large B-cell lymphoma after successful eradication of Helicobacter pylori for gastric MALT lymphoma2006

    • Author(s)
      Iwano M, Watanabe N, Matsushima Y, Seno H, Oki K, Sakurai T, Inagaki H, Okazaki K, Chiba T
    • Journal Title

      Am J Gastroenterol 101(12)

      Pages: 2878-2883

    • Related Report
      2008 Final Research Report
  • [Journal Article] Loss of function of the candidate tumor suppressor prox1 by RNA mutation in human cancer cells2006

    • Author(s)
      Takahashi M, Yoshimoto T, Shimoda M, Kono T, Koizumi M, Yazumi S, Shimada Y, Doi R, Chiba T, Kubo H
    • Journal Title

      Neoplasia 8

      Pages: 1003-10

    • Related Report
      2008 Final Research Report
  • [Journal Article] Gastric mucosal hyperplasia via up-regulation of gastrin induced by persistent activation of gastric innate immunity in MHC class II-deficient mice.2006

    • Author(s)
      Fukui T, Nishio A, Okazaki K, Chiba T, et al.
    • Journal Title

      Gut 55

      Pages: 607-615

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Risk of subsequent development of gastric cancer in patients with previous gastric epithelial neoplasia.2006

    • Author(s)
      Aoi T, Marusawa H, Nato T, Chiba T, Maruyama M
    • Journal Title

      Gut 55

      Pages: 588-589

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Expression of APOBEC2 is transcriptionally regulated by NF-κB in human heoatocytes.2006

    • Author(s)
      Matsumoto T, Marusawa H, Endo Y, Ueda Y, Matsumoto Y, Chiba T
    • Journal Title

      FEBS Lett 580

      Pages: 731-735

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Host factors are important in determining clinical outcomes of Helicobacter pylori infection.2006

    • Author(s)
      Chiba T, Seno H, Marusawa H, Wakatsuki Y, Okazaki K
    • Journal Title

      J Gastroenterol 41

      Pages: 1-9

    • NAID

      10017328156

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Signal tranducers of transcription 3 activation is involved in nuclear accumulation of β-catenin in colorectal cancer.2006

    • Author(s)
      Kawada M, Seno H, Uenoyama Y, Sawabu T, Kanda N, Fukui H, Shimahara Y, Chiba T
    • Journal Title

      Cancer Res 66

      Pages: 2913-2917

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Rapid development of diffuse large B-cell lymphoma after successful eradication of Helicobacter pylori for gastric MALT lymphoma.2006

    • Author(s)
      Iwano M, Watanabe N, Matsushima Y, Seno H, Oki K, Sakurai T, Inagaki H, Okazaki K, Chiba T.
    • Journal Title

      Am J Gastroenterol 101

      Pages: 2878-2883

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Expression of activation-induced cytidine deaminase in human hepatocytes during hepatocarcinogenesis.2006

    • Author(s)
      Kou T, Marusawa H, Chiba T, et al.
    • Journal Title

      Int J Cancer 120

      Pages: 469-476

    • Related Report
      2006 Annual Research Report
  • [Presentation] H. Pylori infection induces gene mutations in gastric epithelial cells via induction of AID2009

    • Author(s)
      千葉勉、松本裕子、丸澤宏之
    • Organizer
      第82回日本細菌学会総会・シンポジウム
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-13
    • Related Report
      2008 Final Research Report
  • [Presentation] Helicobacter pylori感染によるAID発現を介したヒトゲノム異常生成の分子機構2009

    • Author(s)
      丸澤宏之、松本裕子、千葉勉
    • Organizer
      第94回日本消化器病学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2009-05-10
    • Related Report
      2008 Final Research Report
  • [Presentation] Role of AID in H. pylori-induced carcinogenesis2009

    • Author(s)
      T. Chiba
    • Organizer
      MD Anderson Cancer Center&Kyoto Univ. Grad. School of Medicine International Symposium 2009
    • Place of Presentation
      京都
    • Year and Date
      2009-03-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] H. Pylori infection induces gene mutations in gastric epithelial cells via induction of AID2009

    • Author(s)
      千葉勉, 松本裕子, 丸澤宏之
    • Organizer
      第82回 日本細菌学会総会・シンポジウム
    • Place of Presentation
      名古屋
    • Year and Date
      2009-03-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] 遺伝子編集酵素AIDを用いた新しい肝発癌マウスモデルの作成2008

    • Author(s)
      高井淳、丸澤宏之、日合弘、千葉勉、木下和生
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-28
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Mechanism of H.pylori-induced Gene Mutation in Gastric Carcinogenesis2008

    • Author(s)
      T Chibatric
    • Organizer
      AACR Symposium Chemical and Biological Aspects of Inflammation and Cancer
    • Place of Presentation
      Oahu Hawaii(USA)
    • Year and Date
      2008-10-15
    • Related Report
      2008 Final Research Report
  • [Presentation] Mechanism of H. pylori-induced Gene Mutation in Gastric Carcinogenesis2008

    • Author(s)
      Tsutomu Chiba
    • Organizer
      AACR Symposium Chemical and Biological Aspects of Inflammation and Cancer
    • Place of Presentation
      Oahu Hawaii, USA
    • Year and Date
      2008-10-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] Helicobacter pylori infection induces gene mutations in gastric epithelial cells via induction of activation-induced cytidine deaminase(AID)2008

    • Author(s)
      Y Matsumoto, H Marusawa, Y Endo, T Chiba
    • Organizer
      8th International Workshop on Pathogenesis and Host Response in Helicobacter Infections
    • Place of Presentation
      Helsinki(Denmark)
    • Year and Date
      2008-07-04
    • Related Report
      2008 Final Research Report
  • [Presentation] Helicobacter pylori infection induces gene mutations in gastric epithelial cells via induction of activation-induced cytidine deaminase(AID)2008

    • Author(s)
      Yuko Matsumoto, Hiroyuki Marusawa, Yoko Endo, Tsutomu Chiba
    • Organizer
      8th International Workshop on Pathogenesis and Host Response in Helicobacter Infections (session)
    • Place of Presentation
      Helsinki, Denmark
    • Year and Date
      2008-07-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] Helicobacter pylori感染によるAID発現を介した遺伝子変異生成からの胃発癌機構2008

    • Author(s)
      千葉勉
    • Organizer
      第12回腸内細菌学会・シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2008-06-12
    • Related Report
      2008 Final Research Report
  • [Presentation] Helicobacter pylori感染によるAID発現を介しか遺伝子変異生成からの胃発癌機構2008

    • Author(s)
      千葉勉
    • Organizer
      第12回腸内細菌学会・シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2008-06-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] Helicobacter pylori 感染によるAID発現を介したヒトゲノム異常生成の分子機構2008

    • Author(s)
      丸澤宏之, 松本裕子, 千葉勉
    • Organizer
      第94回日本消化器病学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2008-05-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] A novel mechanism for mutagenesis in inflammation-associated carcinogenesis -Roles of activation-induced cytidine deaminase( AID) as a genome mutator-2008

    • Author(s)
      Tsutomu Chiba
    • Organizer
      The 3rd JSI-RCAI Immunology Workshop Regulation of the Mucosal Immune Response -Crosstalk between Basic and Clinical Researches-
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-14
    • Related Report
      2007 Annual Research Report
  • [Presentation] AID serves as a link betweenin flammation and colitis-associated colorectal cancers2008

    • Author(s)
      丸澤宏之
    • Organizer
      8th Colloquium for the Study of Gastrointestinal Defense System (日本消化器免疫学会サテライトシンポジウム)
    • Place of Presentation
      大阪
    • Year and Date
      2008-01-12
    • Related Report
      2007 Annual Research Report
  • [Presentation] The AID-transgenic mouse : a model for inflammation-associated carcinogenesis in digestive organs2007

    • Author(s)
      H Marusawa, Y Endo, T Chiba
    • Organizer
      66th Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-03
    • Related Report
      2008 Final Research Report
  • [Presentation] The AID-transgenic mouse: a model for inflammation-associated carcinogenesis in digestive organs2007

    • Author(s)
      Hiroyuki Marusawa, Yoko Endo, Tsutomu Chiba
    • Organizer
      66th Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] Helicobacter pylori infection p53 gene mutation in gastric epithelial cells via induction of actevation-induced deaminase (AID)2007

    • Author(s)
      T. Chiba, Y. Matsumoto, Y. Endo, H. Marusawa
    • Organizer
      20th International Workshop on Helicobacter and related bacteria in chronic deigestive inflammation・workshop
    • Place of Presentation
      Istanbul, Turkey
    • Year and Date
      2007-09-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] Etopic expression of activation-induced cytidine deaminase in ulcerative colitis-associated colorectal cancers2007

    • Author(s)
      T Kou, H Marusawa, Y Endo, H Nakase, S Fujii, K Kinoshita, T Fujimori, T Honjo, T Chiba
    • Organizer
      Digestive Disease Week andthe 108th Annual Meeting of the American Gastroenterological Association Institute
    • Place of Presentation
      Washington DC(USA)
    • Year and Date
      2007-05-22
    • Related Report
      2008 Final Research Report
  • [Presentation] Etopic expression of activation-induced cytidine deaminase in ulcerative colitis-associated colorectal cancers2007

    • Author(s)
      Tadayuki Kou, Hiroyuki Marusawa, Tsutomu Chiba, et al.
    • Organizer
      Digestive Disease Week and the 108th Annual Meeting of the American Gastroenterological Association Institute
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2007-05-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] High expression of activation induced cytidine deaminase in human bile duct epithelium during cholangiocarcinogenesis2007

    • Author(s)
      J Komori, H Marusawa, T Machimoto, Y Endo, K Kinoshita, T Kou, H Haga, I Ikai, S Uemoto, T Honjo, T Chiba
    • Organizer
      Digestive Disease Week and the 108th Annual Meeting of the American Gastroenterological Association Institute
    • Place of Presentation
      Washington DC(USA)
    • Year and Date
      2007-05-20
    • Related Report
      2008 Final Research Report
  • [Presentation] High expression of activation induced cytidine deaminase in human bile duct epithelium during cholangiocarcinogenesis2007

    • Author(s)
      Junji Komori, Hiroyuki Marusawa, Tsutomu Chiba, et al.
    • Organizer
      Digestive Disease Week and the 108th Annual Meeting of the American Gastroenterological Association Institute・oral sessions
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2007-05-20
    • Related Report
      2007 Annual Research Report
  • [Presentation] Aberrant Expression of Activation-Induced Cytidine Deaminase(AID) and Hepatocarcinogenesis2006

    • Author(s)
      T Kou, H Marusawa, K Kinoshita, I-M Okazaki, Y Ueda, Y Kodama, Y Endo, H Haga, I Ikai, T Chiba
    • Organizer
      Digestive Disease Week and the 107th Annual Meeting of the American Gastroenterological Association Institute
    • Place of Presentation
      Los Angeles(USA)
    • Year and Date
      2006-05-22
    • Related Report
      2008 Final Research Report
  • [Presentation] Anti-Hepatitis B Viral Protein Apobec3g Is Induced By IFN-α Stimulation in Human Hepatocytes2006

    • Author(s)
      Y Tanaka, H Marusawa, Y Matsumoto, Y Ueda, Y Endo, A Takaori-Kondo, I Ikai, T Chiba
    • Organizer
      Digestive Disease Week and the 107th Annual Meeting of the American Gastroenterological Association Institute
    • Place of Presentation
      Los Angeles(USA)
    • Year and Date
      2006-05-22
    • Related Report
      2008 Final Research Report

URL: 

Published: 2006-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi