Comprehensive study on the phenotyping of COPD

• Project/Area Number: 18209029
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Kyoto University
• Principal Investigator: MISHIMA Michiaki Kyoto University, 大学院・医学研究科, 教授 (60190625)
• Co-Investigator(Kenkyū-buntansha): NIIMI Akio 京都大学, 大学院・医学研究科, 准教授 (30252513) ; HIRAI Toyohiro 京都大学, 大学院・医学研究科, 講師 (20359805) ; MURO Shigeo 京都大学, 大学院・医学研究科, 講師 (60344454) ; OGAWA Emiko 京都大学, 大学院・医学研究科, 助教 (00378671) ; OGA Toru 京都大学, 大学院・医学研究科, 講師 (90378670) ; HOSHINO Yuma 京都大学, 産学官連携研究員 (00378746) ; 中野 恭幸 滋賀医科大学, 医学部, 教授 (00362377)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥50,050,000 (Direct Cost: ¥38,500,000、Indirect Cost: ¥11,550,000); Fiscal Year 2008: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000); Fiscal Year 2007: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000); Fiscal Year 2006: ¥30,810,000 (Direct Cost: ¥23,700,000、Indirect Cost: ¥7,110,000)
• Keywords: 画像診断 / 遺伝子多型 / 炎症 / 体重減少 / 胃食道逆流 / 骨そしょう症 / リモデリング / 慢性閉塞性肺疾患 / phenotyping / 動物モデル / 細胞培養 / 肺障害

Research Abstract

マウスの肺気腫生成に対するチオレドキシンの予防効果を明らかにし、肺気腫自然発症のモデルであるklotho mouseの病理画像がフラクタル構造を呈することを明らかにした。さらに、COPDにおいて、GERD(胃食道逆流)の症状を持つ患者は、有意に急性増悪の頻度が高いこと、CT画像における気腫病変の程度は体重(BMI)や骨塩量(BMD)と有意な相関を認めることを明らかにした。

Research Products

• [Journal Article] Features of cough variant asthmaand classic asthma duringmethacholine-inducedbrochoconstriction : a cross-sectional study (2009)
  • Author(s): Matsumoto H, Niimi A, Takemura M, Ueda T,Yamaguchi M, Matsuoka H, Jinnai M, Chin K, Mishima M
  • Journal Title: Cough
• [Journal Article] Specific IgE response to trichophyton and asthma severity (2009)
  • Author(s): Matsuoka H, Niimi A, Matsumoto H, Ueda T,Takemura M, Yamaguchi M, Jinnai M,, Otsuka K,Oguma T, Takeda T, Ito I, Chin K, Amitani R,Mishima M
  • Journal Title: Chest 135(4) Pages: 898-903
• [Journal Article] Eosinophilic airway disorders associated withchronic cough (2009)
  • Author(s): Niimi A, Matsumoto H, Mishima M
  • Journal Title: Pulm Pharmacol Ther 22(2) Pages: 114-20
• [Journal Article] Body mass index in male patients with COPD : correlation with low attenuation areas on CT. (2009)
  • Author(s): Ogawa E, Nakano Y, Ohara T, Muro S, Hirai T,Sato S, Sakai H, Tsukino M, Kinose D, NishiokaM, Niimi A, Chin K, Par 辿 PD, Mishima M.
  • Journal Title: Thorax 64(1) Pages: 20-5
• [Journal Article] Features of cough variant asthma and classic asthma during methacholine-induced brochoconstriction : a cross-sectional study (2009)
  • Author(s): Matsumoto H, Niimi A, Takemura M, Ueda T, Yamaguchi M, Matsuoka H, Jinnai M, Chin K, Mishima M.
  • Journal Title: Cough. 9 ; 5:3
  • NAID: 120004770219
• [Journal Article] Specific IgE response to trichophyton and asthma severity. (2009)
  • Author(s): Matsuoka H, Niimi A, Matsumoto H, Ueda T, Takemura M, Yamaguchi M, Jinnai M, Otsuka K, Oguma T, Takeda T, I to I, Chin K, Amitani R, Mishima M.
  • Journal Title: Chest. 135 (4) Pages: 898-903
• [Journal Article] Eosinophilic airway disorders associated with chronic cough. (2009)
  • Author(s): Niimi A, Matsumoto H, Mishima M.
  • Journal Title: Pulm Pliarmacol Ther. 22(2) Pages: 114-20
• [Journal Article] Body mass index in male patients with COPD : correlation with low attenuation areas on CT. (2009)
  • Author(s): Ogawa E, Nakano Y, Ohara T, Muro S, Hirai T, Sato S, Sakai H, Tsukino M, Kinose D, Nishioka M, Niimi A, Chin K, Pare PD, Mishima M.
  • Journal Title: Thorax 64(1) Pages: 20-5
• [Journal Article] Relationship between pulmonary emphysema and osteoporosis assessed by CT in patients with COPD (2008)
  • Author(s): Ohara T, Hirai T, Muro S, Haruna A, Terada K,Kinose D, Marumo S, Ogawa E, Hoshino Y,Niimi A, Chin K, Mishima M.
  • Journal Title: Chest 134(6) Pages: 1244-9
• [Journal Article] Gastroesophagealreflux-associated chronic cough in an adolescentand the diagnostic implications : a case report (2008)
  • Author(s): Jinnai M, Niimi A, Takemura M, Matsumoto H,Konda Y, Mishima M.
  • Journal Title: Cough 15 Pages: 5-5
• [Journal Article] Impact ofgastro-oesophageal reflux disease symptoms onCOPD exacerbation (2008)
  • Author(s): Terada K, Muro S, Sato S, Ohara T, Haruna A,Marumo S, Kinose D, Ogawa E, Hoshino Y,Niimi A, Terada T, Mishima M
  • Journal Title: Thorax 63(11) Pages: 951-5
• [Journal Article] Redox-basedtherapeutics for lung diseases (2008)
  • Author(s): Hoshino Y, Mishima M
  • Journal Title: Antioxid Redox Signal 10(4) Pages: 701-4
• [Journal Article] Sputum levels of transforming growth factor-beta1 in asthma : relation to clinical and computed tomography findings (2008)
  • Author(s): Yamaguchi M, Niimi A, Matsumoto H, UedaT, Takemura M, Matsuoka H, Jinnai M, OtsukaK, Oguma T, Takeda T, Ito I, Chin K, MishimaM
  • Journal Title: J Investig Allergol Clin Immunol 18(3) Pages: 202-6
• [Journal Article] Longitudinal study of airway dimensions in chronic obstructive pulmonary disease using computed tomography (2008)
  • Author(s): Ohara T, Hirai T, Sato S, Terada K, Kinose D, Haruna A, Marumo S, Nishioka M, Ogawa E,Nakano Y, Hoshino Y, Ito Y, Matsumoto H,Niimi A, Mio T, Chin K, Muro S, Mishima M.
  • Journal Title: Respirology 13(3) Pages: 372-8
• [Journal Article] Thioredoxin-1 ameliorates cigarette smoke-induced lung inflammation and emphysema in mice (2008)
  • Author(s): Sato A, Hoshino Y, Hara T, Muro S, Nakamura H, Mishima M, Yodoi J
  • Journal Title: J Pharmacol Exp Ther 325(2) Pages: 380-8
• [Journal Article] TGFB1 promoter polymorphism C-509T andpathophysiology of asthma (2008)
  • Author(s): Ueda T, Niimi A, Matsumoto H, Takemura M, Yamaguchi M, Matsuoka H, Jinnai M, Chin K, Minakuchi M, Cheng L, Shirakawa T, Mishima M.
  • Journal Title: J Allergy ClinImmunol 121(3) Pages: 659-64
• [Journal Article] Relationship between pulmonary empliysema and osteoporosis assessed by CT in patients with COPD. (2008)
  • Author(s): Ohara T, Hirai T, Muro S, Haruna A, Terada K, Kinose D, Marumo S, Ogawa E, Hoshino Y, Niimi A, Chin K, Mishima M.
  • Journal Title: Chest 134(6) Pages: 1244-9
• [Journal Article] Gastroesophageal reflux-associated chronic cough in an adolescent and thediagnostic implications : a case report (2008)
  • Author(s): Jinnai M, Niimi A, Takemura M, Matsumoto H, Konda Y, Mishima M.
  • Journal Title: Cough. 15 ; 4:5
• [Journal Article] Sputum levels of transforming growth factor-betal in asthma : relation to clinical and computed tomography findings. (2008)
  • Author(s): Yamaguchi M, Niimi A, Matsumoto H, Ueda T, Takemura M, Matsuoka H, Jinnai M, Otsuka K, Oguma T, Takeda T, Ito I, Chin K, Mishima M.
  • Journal Title: J Investig Allergol Clin Immunol. 18(3) Pages: 202-6
• [Journal Article] Impact of gastro-oesophageal reflux disease symptoms on COPD exacerbation. (2008)
  • Author(s): Terada K, Muro S, Sato S, Ohara T, Haruna A, Marumo S, Kinose D, Ogawa E, Hoshino Y, Niimi A, Terada T, Mishima M.
  • Journal Title: Thorax 63(11) Pages: 951-5
• [Journal Article] Longitudinal study of airway dimensions in chronic obstructive pulmonary disease using computed tomography. (2008)
  • Author(s): Ohara T, Hirai T, Sato S, Terada K, Kinose D, Haruna A, Marumo S, Nishioka M, Ogawa E, Nakano Y, Hoshino Y, Ito Y, Matsumoto H, Niimi A, Mio T, Chin K, Muro S, Mishima M.
  • Journal Title: Respirology 13(3) Pages: 372-8
• [Journal Article] Thioredoxin-1 ameliorates cigarette smoke-induced lung inflammation and emphysemain mice (2008)
  • Author(s): Sato A, Hoshino Y, Hara T, Muro S, Nakamura H, Mishima M, Yodoi J.
  • Journal Title: J Pharmacol Exp Ther. 325(2) Pages: 380-8
• [Journal Article] Plasma thioredoxin, a novel oxidative stress marker, in patients with obstructive sleep apnea before and after nasal continuous positive airway pressure. (2008)
  • Author(s): Takahashi K, Chin K, Nakamura H, Morita S, Sumi K, Oga T, Matsumoto H, Niimi A, Fukuhara S, Yodoi J, Mishima M.
  • Journal Title: Antioxid Redox Signal. 10(4) Pages: 715-26
• [Journal Article] Redox-based therapeutics for lung diseases. (2008)
  • Author(s): Hoshino Y, Mishima M.
  • Journal Title: Antioxid Redox Signal. 10(4) Pages: 701-4
• [Journal Article] TGFB1 promoter polymorphism C-509T and pathophysiology of asthma. (2008)
  • Author(s): Ueda T, Niimi A, Matsumoto H, Takemura M, Yamaguchi M, Matsuoka H, Jinnai M, Chin K, Minakuchi M, Cheng L, Shirakawa T, Mishima M.
  • Journal Title: J Allergy Clin Immunol. 121(3) Pages: 659-64
• [Journal Article] Longitudinal study of airway dimensions in chronic obstructive pulmonary disease using computed tomography. (2008)
  • Author(s): Ohara T, Hirai T, Sato S, Terada K, Kinose D, Haruna A, Marumo S, Nishioka M, Ogawa E, Nakano Y, Hoshino Y, Ito Y, Matsumoto H, Niimi A, Mio T, Chin K, Muro S, Mishima M.
  • Journal Title: Respirology. 13(3) Pages: 372-8
  • Peer Reviewed
• [Journal Article] Thioredoxin-1 ameliorates cigarette smoke-induced lung inflammation and emphysema in mice (2008)
  • Author(s): Sato A, Hoshino Y, Hara T, Muro S, Nakamura H, Mishima M, Yodoi J.
  • Journal Title: J Pharmacol Exp Ther. 325(2) Pages: 380-8
  • Peer Reviewed
• [Journal Article] TGFB1 promoter polymorphism C-509T and pathophysiology of asthma. (2008)
  • Author(s): Ueda T, Niimi A, Matsumoto H, Takemura M, Yamaguchi M, Matsuoka H, Jinnai M, Chin K, Minakuchi M, Cheng L, Shirakawa T, Mishima
  • Journal Title: J Allergy Clin Immunol. 121(3) Pages: 659-64
  • Peer Reviewed
• [Journal Article] Atopic features of cough variantasthma and classic asthma with wheezing (2007)
  • Author(s): Takemura M, Niimi A, Matsumoto H, Ueda T, Yamaguchi M, Matsuoka H, Jinnai M, Chin K, Mishima M.
  • Journal Title: ClinExp Allergy 37(12) Pages: 1833-9
• [Journal Article] Corticosteroid-induced myopathy mimickingtherapy-resistant asthma (2007)
  • Author(s): Yamaguchi M, Niimi A, Minakuchi M,Matsumoto H, Shimizu K, Chin K, Mishima M.
  • Journal Title: Ann Allergy AsthmaImmunol 99(4) Pages: 371-4
• [Journal Article] Analysis of longitudinalchanges in the psychological status of patientswith asthma (2007)
  • Author(s): Oga T, Nishimura K, Tsukino M, Sato S,Hajiro T, Mishima M
  • Journal Title: Respir Med 101(10) Pages: 2133-8
• [Journal Article] Neurotropin demonstrates cytoprotective effects in lung cells through the induction of thioredoxin-1 (2007)
  • Author(s): Hoshino Y, Nakamura T, Sato A, Mishima M,Yodoi J, Nakamura H
  • Journal Title: Am J Respir Cell MolBiol 37(4) Pages: 438-46
• [Journal Article] Airway wallthickening in patients with cough variant asthmaand nonasthmatic chronic cough (2007)
  • Author(s): Matsumoto H, Niimi A, Tabuena RP,Takemura M, Ueda T, Yamaguchi M, MatsuokaH, Jinnai M, Chin K, Mishima M.
  • Journal Title: Chest 131(4) Pages: 1042-9
• [Journal Article] Morphological mechanism of the development ofpulmonary emphysema in klotho mice (2007)
  • Author(s): Sato A, Hirai T, Imura A, Kita N, Iwano A,Muro S, Nabeshima Y, Suki B,Mishima M.
  • Journal Title: Proc NatlAcad Sci USA 104(7) Pages: 2361-5
• [Journal Article] Prevalence and clinical manifestations of gastro-oesophageal reflux-associated chronic cough in the Japanese population (2007)
  • Author(s): Matsumoto H, Niimi A, Takemura M, Ueda T,Yamaguchi M, Matsuoka H, Jinnai M, Chin K,Mishima M.
  • Journal Title: Cough Pages: 3-1
  • NAID: 120004770220
• [Journal Article] Longitudinal deteriorations in patient reported outcomes inpatients with COPD (2007)
  • Author(s): Oga T, Nishimura K, Tsukino M, Sato S,Hajiro T, Mishima M.
  • Journal Title: Respir Med 101(1) Pages: 146-53
• [Journal Article] Neurotropin demonstrates cytoprotective effects in lung cells through the induction of thioredoxin-1. (2007)
  • Author(s): Hoshino Y, Nakamura T, Sato A, Mishima M, Yodoi J, Nakamura H.
  • Journal Title: Am J Respir Cell Mol Biol. 37(4) Pages: 438-46
  • Peer Reviewed
• [Journal Article] Atopic features of cough variant asthma and classic asthma with wheezing (2007)
  • Author(s): Takemura M, Niimi A, Matsumoto H, Ueda T, Yamaguchi M, Matsuoka H, Jinnai M, Chin K, Mishima M.
  • Journal Title: Clin Exp Allergy. 37(12) Pages: 1833-9
  • Peer Reviewed
• [Journal Article] Elevation of serum thioredoxin in patients with gefitinib-induced interstitial lung disease. (2007)
  • Author(s): Sakuma K, Nakamura H, Nakamura T, Hoshino Y, Ueda S, Ichikawa M, Tabata C, Fujita S, Masago K, Yodoi J, Mishima M, Mio T.
  • Journal Title: Intern Med. 46(23) Pages: 1905-9
  • NAID: 130000078603
  • Peer Reviewed
• [Journal Article] Corticosteroid-induced myopathy mimicking therapy-resistant asthma. (2007)
  • Author(s): Yamaguchi M, Niimi A, Minakuchi M, Matsumoto H, Shimizu K, Chin K, Mishima M.
  • Journal Title: Ann Allergy Asthma Immunol. 99(4) Pages: 371-4
  • Peer Reviewed
• [Journal Article] Analysis of longitudinal changes in the psychological status of patients with asthma. (2007)
  • Author(s): Oga T, Nishimura K, Tsukino M, Sato S, Hajiro T, Mishima M.
  • Journal Title: Respir Med. 101(10) Pages: 2133-8
  • Peer Reviewed
• [Journal Article] Morphological mechanism of the development of pulmonary emphysema in klotho mice. (2007)
  • Author(s): Sato A, Hirai T, Imura A, Kita N, Iwano A, Muro S, Nabeshima Y, Suki B, Mishima M
  • Journal Title: Proc Natl Acad Sci U S A. Feb 13;104 (7)
• [Journal Article] Role of small airways in asthma : investigation using high-resolution computed tomography (2006)
  • Author(s): Ueda T, Niimi A, Matsumoto H, Takemura M, Hirai T, Yamaguchi M, Matsuoka H, Jinnai M, Muro S, Chin K, Mishima M.
  • Journal Title: J Allergy Clin Immunol 118(5) Pages: 1019-25
• [Journal Article] Thioredoxin-1 suppresses systemic inflammatory responses against cigarette smoking (2006)
  • Author(s): Sato A, Hara T, Nakamura H, Kato N, Hoshino Y, Kondo N, Mishima M, Yodoi J.
  • Journal Title: Antioxid Redox Signal 8(9-10) Pages: 1891-6
• [Journal Article] Comparison of airway dimensions in different anatomic locations on chest CT in patients with COPD (2006)
  • Author(s): Ohara T, Hirai T, Sato S, Sato A, Nishioka M, Muro S, Mishima M
  • Journal Title: Respirology 11(5) Pages: 579-85
• [Journal Article] High sensitivity C-reactive protein in asthma (2006)
  • Author(s): Takemura M, Matsumoto H, Niimi A, Ueda T, Matsuoka H, Yamaguchi M, Jinnai M, Muro S,Hirai T, Ito Y, Nakamura T, Mio T, Chin K, Mishima M.
  • Journal Title: Eur Respir J 27(5) Pages: 908-12
• [Journal Article] Prognosis of cough variant asthma : a retrospective analysis (2006)
  • Author(s): Matsumoto H, Niimi A, Takemura M, Ueda T, Tabuena R, Yamaguchi M, Matsuoka H, Hirai T, Muro S, Ito Y, Mio T, Chin K, Nishiyama H, Mishima M.
  • Journal Title: J Asthma 43(2) Pages: 131-5
• [Journal Article] Dyspnoea with activities of dailyliving versus peak dyspnoea during exercise in male patients with COPD (2006)
  • Author(s): Oga T, Nishimura K, Tsukino M, Hajiro T, Mishima M.
  • Journal Title: Respir Med 100(6) Pages: 965-71
• [Journal Article] Thioredoxin-l suppresses systemic inflammatory responses against cigarette smoking. (2006)
  • Author(s): Sato A, Hara T, Nakamura H, Kato N, Hoshino Y, Kondo N, Mishima M
  • Journal Title: Antioxid Redox Signal 8 (9-10) Pages: 1891-1896
• [Journal Article] Prognosis of cough variant asthma : a retrospective analysis. (2006)
  • Author(s): Motsumoto, H., A.Niimi, M.Takemura, T.Ueda, R.Tabuena, M.Yamaguchi, H.Matsuoka, T.Hirai, S.Muro, Y.Ito, T.Mio, K.Chin, H.Nishiyama, M.Mishima
  • Journal Title: J Asthma 43 (2) Pages: 131-135
• [Journal Article] Role of small airways in asthma : Investigation using high-resolution computed tomography. (2006)
  • Author(s): Ueda T, Niimi A, Matsumoto H, Takemura M, Hirai T, Yamaguchi M, Matsuoka H, Jinnai M, Muro S, Chin K, Mishima M
  • Journal Title: J Allergy Clin Immunol 118 Pages: 1019-1025
• [Journal Article] Comparison of airway dimensions in different anatomic locations on chest CT in patients with COPD. (2006)
  • Author(s): Ohara T, Hirai T, Sato S, Sato A, Nishioka M, Muro S, Mishima M
  • Journal Title: Respirology Sep;11 (5) Pages: 579-585
• [Journal Article] Cough-ReflexSensitivity to Inhaled Capsaicin in ChronicObstructive Pulmonary Disease : the Impact onExacerbation Frequency
  • Author(s): Kunihiko Terada, M.D., Shigeo Muro, M.D.,Ph. D., Tadashi Ohara, M.D., Ph. D., AkaneHaruna, M.D., Satoshi Marumo, M.D., MegumiKudo, M.D., Emiko Ogawa, M.D., Ph. D.,Yuma Hoshino, M.D., Ph. D., Toyohiro Hirai,M.D., Ph. D., Akio Niimi, M.D., Ph. D.,Michiaki Mishima, M.D., Ph. D.
  • Journal Title: Respirology (in press)
• [Journal Article] Effect of inhaled corticosteroidson small airways in asthma: Investigation usingimpulse oscillometry
  • Author(s): Yamaguchi M, Niimi A, Ueda T, TakemuraM, Matsuoka H, Jinnai M, Otsuka K, Oguma T,Takeda T, Ito I, Matsumoto H, Hirai T, Chin K,Mishima M.
  • Journal Title: Pulm Pharmacol Ther (in press)
• [Journal Article] Impact of gastro-oesophageal reflux disease symptoms on chronic obstructive pulmonary disease exacerbation.
  • Author(s): Kunihiko Terada, Shigeo Muro, Susumu Sato, Tadashi Ohara, Akane Haruna, Satoshi Marumo, Daisuke Kinose, Emiko Ogawa, Yuma Hoshino, Akio Niimi, Michiaki Mishima.
  • Journal Title: Thorax (in press)
  • Peer Reviewed
• [Journal Article] M. Airway wall thickening in patients with cough variant asthma and nonasthmatic chronic cough.
  • Author(s): Matsumoto H, Niimi A, Tabuena RP, Takemura M, Ueda T, Yamaguchi M, Matsuoka H, Jinnai M, Chin K, Mishima
  • Journal Title: Chest (in press)
• [Presentation] Regulation of Connective Tissue Growth Factor Gene Expression by Lipopolysaccharide in Bronchial Epithelial Cells (2009)
  • Author(s): M. Nishioka, E. Ogawa, T. Hirai, S. Muro, M. Mishima
  • Organizer: 2006 International Conference of American Thoracic Society
  • Place of Presentation: San Diego Convention Center, San Diego, California, USA
• [Presentation] Sputum leukocytosis on stable condition predicts chronic obstructive pulmonary disease exacerbations (2008)
  • Author(s): Kunihiko Terada, Shigeo Muro, TadashiOhara, Akane Haruna, Satoshi Marumo, Daisuke Kinose, Emiko Ogawa, Yutaka Ito, Satoshi Ichiyama, Michiaki Mishima
  • Organizer: 2008 International Conferenceof American Thoracic Society
  • Place of Presentation: Metro Toronto Convention Centre, Toronto, Canada
• [Presentation] Relation between smallairways and patient reported outcomes in chronic obstructive pulmonary disease (2008)
  • Author(s): Akane Haruna, Toru Oga, Shigeo Muro, Tadashi Ohara, Kunihiko Terada, Daisuke Kinose, Satoshi Marumo, Yuma Hoshino, Toyohiro Hirai, Emiko Ogawa, Kazuo Chin, Michiaki Mishima
  • Organizer: 2008 International Conference of American ThoracicSociety
  • Place of Presentation: Metro Toronto Convention Centre, Toronto, Canada
• [Presentation] Chest Subcutaneous Fat Mass Measured by Chest Computed Tomography Correlated with Low Attenuation Areas in COPD (2008)
  • Author(s): E. Ogawa., T. Ohara, Kinose, Nishioka. Sakai, MD, S. Muro, T. Hirai, Y. Nakano, M. Mishima
  • Organizer: 2008 International Conference of American Thoracic Society
  • Place of Presentation: MetroToronto Convention Centre, Toronto, Canada
• [Presentation] Impaired swallowing reflex predisposes to COPD exacerbations (2008)
  • Author(s): Kunihiko Terada, Shigeo Muro, TadashiOhara, Megumi Kudo, Emiko Ogawa, YumaHoshino, Toyohiro Hirai, Akio Niimi, MichiakiMishima
  • Organizer: 18th Annual Conference of European Respiratory Society
  • Place of Presentation: Messe Sud, Berlin, Germany
• [Presentation] TNF-alpha Modulates Expressions of MMPs and Migratory Function of Human Airway Smooth Muscle Cells (2008)
  • Author(s): Ito I, Hamid Q, Niimi A, Matsumoto H,Yamaguchi M, Matsuoka H, Jinnai M, OtsukaK, Takeda T, Nakaji H, Mishima M
  • Organizer: 2008 International Conference of American Thoracic Society
  • Place of Presentation: Metro Toronto Convention Centre, Toronto, Canada
• [Presentation] Relationship between Small Airways Function, and Health Status, Dyspneaand Disease Control in Asthma (2008)
  • Author(s): Takeda T, Oga T, Niimi A, Matsumoto H, Ito I, Yamaguchi M, Matsuoka H, Jinnai M, Otsuka K, Oguma T, Nakaji H, Chin K, Mishima M
  • Organizer: 2008 International Conference of American Thoracic Society
  • Place of Presentation: Metro Toronto Convention Centre, Toronto, Canada
• [Presentation] Arterial Hypoxia Correlated with the Inflammatory Profile in Induced Sputum from COPD Patients (2007)
  • Author(s): Sato, S. Muro, S. Sato, M. Nishioka, Y. Hoshino, E. Ogawa, T. Hirai, H. Nakamura, J. Yodoi, M. Mishima
  • Organizer: 2007 International Conference of American Thoracic Society
  • Place of Presentation: Moscone Convention Center, San Francisco, California, USA
• [Presentation] Corticosteroid Suppressed LPS Induced NOD2 Gene Expression in Airway Epithelial Cells/D (2007)
  • Author(s): Kinose, E. Ogawa, M. Nishioka, Y. Hoshino, T. Hirai, S. Muro, M. Mishima
  • Organizer: 2007 International Conference of American Thoracic Society
  • Place of Presentation: Moscone Convention Center, San Francisco, California, USA
• [Presentation] Thioredoxin Suppressed Cigarette Smoke Induced Emphysema in Mice (2007)
  • Author(s): Sato, Y. Hoshino, M. Takenaka, S. Muro, H. Nakamura, J. Yodoi, M. Mishima
  • Organizer: 2007 International Conference of American Thoracic Society
  • Place of Presentation: Moscone Convention Center, San Francisco, California, USA
• [Presentation] Respiratory Resistance In COPD Patients Using Impulse Oscillometry (2007)
  • Author(s): S. SATO, T. HIRAI, S. MURO AND M. MISHIMA
  • Organizer: Biomedical Engineering Symposium
  • Place of Presentation: Losangels, USA
• [Presentation] Morphological Mechanism Of The Development Of ulmonary Emphysema In Klotho Mice (2007)
  • Author(s): T. HIRAI, A. SATO, S. MURO, A. IMURA, Y. NABESHIMA AND M. MISHIMA
  • Organizer: Biomedical Engineering Symposium
  • Place of Presentation: Losangels, USA.
• [Presentation] Impacts of gastro-oesophageal reflux symptoms on exacerbations of COPD (2007)
  • Author(s): K. Terada, S. Muro, A. Niimi, E. Ogawa, Y. Hoshino, S. Sato, T. Ohara, D. Kinose, A. Haruna, S. Marumo, M. Mishima
  • Organizer: 17th Annual Conference of European Respiratory Society
  • Place of Presentation: Stockholm International Fair and Congress Center, Stockholm, Sweden
• [Presentation] Geographic Difference in Chronic Cough Etiology : Comparison of Japan with the UK (2007)
  • Author(s): Niimi A, Ueda T, Matsumoto H, Chung KF, Mishima M
  • Organizer: 2007 International Conference of American Thoracic Society
  • Place of Presentation: Moscone Convention Center, San Francisco, California, USA
• [Presentation] Dynamic Property of Central Airway Walls as Assessed by Computed Tomography (CT) : Correlation with Asthma Pathophysiology. (2007)
  • Author(s): Yamaguchi M, Niimi A, Matsumoto H,Ueda T, Takemura M, Matsuoka H, Jinnai M,Mishima M
  • Organizer: 2007 International Conference of American Thoracic Society
  • Place of Presentation: Moscone Convention Center, San Francisco, California, USA
• [Presentation] Thioredoxin Prevents Cigarette Smoke Induced Oxidative Stress and Apoptosis (2006)
  • Author(s): A. Sato, Y. Hoshino, H. Nakamura, M.Narita, S. Muro, M. Mishima, J. Yodoi
  • Organizer: 2006 International Conference of American Thoracic Society
  • Place of Presentation: San Diego Convention Center, San Diego, California, USA
• [Presentation] Annual Changes in Computed Tomography Measurements and Pulmonary Function in Patients with Chronic Obstructive Pulmonary Disease (2006)
  • Author(s): T. Ohara, T. Hirai, S. Sato, E. Ogawa, A. Sato,M. Nishioka, K. Terada, Kinose, S. Muro, M. Mishima
  • Organizer: 2006 International Conference of American Thoracic Society
  • Place of Presentation: San Diego Convention Center, San Diego, California, USA
• [Presentation] Body Mass Index in Patients with Chronic Obstructive Pulmonary Disease ; Correlation with Low Attenuation Areas on Computed Tomography (2006)
  • Author(s): E. Ogawa, Y. Nakano, S. Muro, H. Sakai, T.Hirai, M. Mishima
  • Organizer: 2006 International Conference of American Thoracic Society
  • Place of Presentation: San Diego Convention Center, San Diego, California, USA
• [Presentation] Comparison of airway dimensions in different anatomic locations on chest CT in patients with COPD (2006)
  • Author(s): Tadashi OHARA, Toyohiro HIRAI, Susumu SATO, Atsuyasu SATO, Michiyoshi NISHIOKA, Shigeo MURO, Michiaki MISHIMA
  • Organizer: 11th Congress of the Asian Pacific Society of Respirology
  • Place of Presentation: Kyoto International Conference Hall, Kyoto, Japan
• [Presentation] Longitudinal deteriorations in patient centered versus physiological measurements in patients with COPD (2006)
  • Author(s): T. Oga, K. Nishimura, M. Tsukino, S. Sato, T.Hajiro, M. Mishima
  • Organizer: 16th Annual Congress of European Respiratory Society
  • Place of Presentation: International Congress Centre Munich, Munich, German
• [Remarks] Harasawa Memorial Award(Asia Pacific Society of Respiratory Medicine)2008.11