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Comprehensive study on the phenotyping of COPD

Research Project

Project/Area Number 18209029
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionKyoto University

Principal Investigator

MISHIMA Michiaki  Kyoto University, 大学院・医学研究科, 教授 (60190625)

Co-Investigator(Kenkyū-buntansha) NIIMI Akio  京都大学, 大学院・医学研究科, 准教授 (30252513)
HIRAI Toyohiro  京都大学, 大学院・医学研究科, 講師 (20359805)
MURO Shigeo  京都大学, 大学院・医学研究科, 講師 (60344454)
OGAWA Emiko  京都大学, 大学院・医学研究科, 助教 (00378671)
OGA Toru  京都大学, 大学院・医学研究科, 講師 (90378670)
HOSHINO Yuma  京都大学, 産学官連携研究員 (00378746)
中野 恭幸  滋賀医科大学, 医学部, 教授 (00362377)
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥50,050,000 (Direct Cost: ¥38,500,000、Indirect Cost: ¥11,550,000)
Fiscal Year 2008: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Fiscal Year 2007: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Fiscal Year 2006: ¥30,810,000 (Direct Cost: ¥23,700,000、Indirect Cost: ¥7,110,000)
Keywords画像診断 / 遺伝子多型 / 炎症 / 体重減少 / 胃食道逆流 / 骨そしょう症 / リモデリング / 慢性閉塞性肺疾患 / phenotyping / 動物モデル / 細胞培養 / 肺障害
Research Abstract

マウスの肺気腫生成に対するチオレドキシンの予防効果を明らかにし、肺気腫自然発症のモデルであるklotho mouseの病理画像がフラクタル構造を呈することを明らかにした。さらに、COPDにおいて、GERD(胃食道逆流)の症状を持つ患者は、有意に急性増悪の頻度が高いこと、CT画像における気腫病変の程度は体重(BMI)や骨塩量(BMD)と有意な相関を認めることを明らかにした。

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (77 results)

All 2009 2008 2007 2006 Other

All Journal Article (56 results) (of which Peer Reviewed: 9 results) Presentation (20 results) Remarks (1 results)

  • [Journal Article] Features of cough variant asthmaand classic asthma duringmethacholine-inducedbrochoconstriction : a cross-sectional study2009

    • Author(s)
      Matsumoto H, Niimi A, Takemura M, Ueda T,Yamaguchi M, Matsuoka H, Jinnai M, Chin K, Mishima M
    • Journal Title

      Cough

    • Related Report
      2008 Final Research Report
  • [Journal Article] Specific IgE response to trichophyton and asthma severity2009

    • Author(s)
      Matsuoka H, Niimi A, Matsumoto H, Ueda T,Takemura M, Yamaguchi M, Jinnai M,, Otsuka K,Oguma T, Takeda T, Ito I, Chin K, Amitani R,Mishima M
    • Journal Title

      Chest 135(4)

      Pages: 898-903

    • Related Report
      2008 Final Research Report
  • [Journal Article] Eosinophilic airway disorders associated withchronic cough2009

    • Author(s)
      Niimi A, Matsumoto H, Mishima M
    • Journal Title

      Pulm Pharmacol Ther 22(2)

      Pages: 114-20

    • Related Report
      2008 Final Research Report
  • [Journal Article] Body mass index in male patients with COPD : correlation with low attenuation areas on CT.2009

    • Author(s)
      Ogawa E, Nakano Y, Ohara T, Muro S, Hirai T,Sato S, Sakai H, Tsukino M, Kinose D, NishiokaM, Niimi A, Chin K, Par 辿 PD, Mishima M.
    • Journal Title

      Thorax 64(1)

      Pages: 20-5

    • Related Report
      2008 Final Research Report
  • [Journal Article] Features of cough variant asthma and classic asthma during methacholine-induced brochoconstriction : a cross-sectional study2009

    • Author(s)
      Matsumoto H, Niimi A, Takemura M, Ueda T, Yamaguchi M, Matsuoka H, Jinnai M, Chin K, Mishima M.
    • Journal Title

      Cough. 9 ; 5:3

    • NAID

      120004770219

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Specific IgE response to trichophyton and asthma severity.2009

    • Author(s)
      Matsuoka H, Niimi A, Matsumoto H, Ueda T, Takemura M, Yamaguchi M, Jinnai M, Otsuka K, Oguma T, Takeda T, I to I, Chin K, Amitani R, Mishima M.
    • Journal Title

      Chest. 135 (4)

      Pages: 898-903

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Eosinophilic airway disorders associated with chronic cough.2009

    • Author(s)
      Niimi A, Matsumoto H, Mishima M.
    • Journal Title

      Pulm Pliarmacol Ther. 22(2)

      Pages: 114-20

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Body mass index in male patients with COPD : correlation with low attenuation areas on CT.2009

    • Author(s)
      Ogawa E, Nakano Y, Ohara T, Muro S, Hirai T, Sato S, Sakai H, Tsukino M, Kinose D, Nishioka M, Niimi A, Chin K, Pare PD, Mishima M.
    • Journal Title

      Thorax 64(1)

      Pages: 20-5

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Relationship between pulmonary emphysema and osteoporosis assessed by CT in patients with COPD2008

    • Author(s)
      Ohara T, Hirai T, Muro S, Haruna A, Terada K,Kinose D, Marumo S, Ogawa E, Hoshino Y,Niimi A, Chin K, Mishima M.
    • Journal Title

      Chest 134(6)

      Pages: 1244-9

    • Related Report
      2008 Final Research Report
  • [Journal Article] Gastroesophagealreflux-associated chronic cough in an adolescentand the diagnostic implications : a case report2008

    • Author(s)
      Jinnai M, Niimi A, Takemura M, Matsumoto H,Konda Y, Mishima M.
    • Journal Title

      Cough 15

      Pages: 5-5

    • Related Report
      2008 Final Research Report
  • [Journal Article] Impact ofgastro-oesophageal reflux disease symptoms onCOPD exacerbation2008

    • Author(s)
      Terada K, Muro S, Sato S, Ohara T, Haruna A,Marumo S, Kinose D, Ogawa E, Hoshino Y,Niimi A, Terada T, Mishima M
    • Journal Title

      Thorax 63(11)

      Pages: 951-5

    • Related Report
      2008 Final Research Report
  • [Journal Article] Redox-basedtherapeutics for lung diseases2008

    • Author(s)
      Hoshino Y, Mishima M
    • Journal Title

      Antioxid Redox Signal 10(4)

      Pages: 701-4

    • Related Report
      2008 Final Research Report
  • [Journal Article] Sputum levels of transforming growth factor-beta1 in asthma : relation to clinical and computed tomography findings2008

    • Author(s)
      Yamaguchi M, Niimi A, Matsumoto H, UedaT, Takemura M, Matsuoka H, Jinnai M, OtsukaK, Oguma T, Takeda T, Ito I, Chin K, MishimaM
    • Journal Title

      J Investig Allergol Clin Immunol 18(3)

      Pages: 202-6

    • Related Report
      2008 Final Research Report
  • [Journal Article] Longitudinal study of airway dimensions in chronic obstructive pulmonary disease using computed tomography2008

    • Author(s)
      Ohara T, Hirai T, Sato S, Terada K, Kinose D, Haruna A, Marumo S, Nishioka M, Ogawa E,Nakano Y, Hoshino Y, Ito Y, Matsumoto H,Niimi A, Mio T, Chin K, Muro S, Mishima M.
    • Journal Title

      Respirology 13(3)

      Pages: 372-8

    • Related Report
      2008 Final Research Report
  • [Journal Article] Thioredoxin-1 ameliorates cigarette smoke-induced lung inflammation and emphysema in mice2008

    • Author(s)
      Sato A, Hoshino Y, Hara T, Muro S, Nakamura H, Mishima M, Yodoi J
    • Journal Title

      J Pharmacol Exp Ther 325(2)

      Pages: 380-8

    • Related Report
      2008 Final Research Report
  • [Journal Article] TGFB1 promoter polymorphism C-509T andpathophysiology of asthma2008

    • Author(s)
      Ueda T, Niimi A, Matsumoto H, Takemura M, Yamaguchi M, Matsuoka H, Jinnai M, Chin K, Minakuchi M, Cheng L, Shirakawa T, Mishima M.
    • Journal Title

      J Allergy ClinImmunol 121(3)

      Pages: 659-64

    • Related Report
      2008 Final Research Report
  • [Journal Article] Relationship between pulmonary empliysema and osteoporosis assessed by CT in patients with COPD.2008

    • Author(s)
      Ohara T, Hirai T, Muro S, Haruna A, Terada K, Kinose D, Marumo S, Ogawa E, Hoshino Y, Niimi A, Chin K, Mishima M.
    • Journal Title

      Chest 134(6)

      Pages: 1244-9

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Gastroesophageal reflux-associated chronic cough in an adolescent and thediagnostic implications : a case report2008

    • Author(s)
      Jinnai M, Niimi A, Takemura M, Matsumoto H, Konda Y, Mishima M.
    • Journal Title

      Cough. 15 ; 4:5

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Sputum levels of transforming growth factor-betal in asthma : relation to clinical and computed tomography findings.2008

    • Author(s)
      Yamaguchi M, Niimi A, Matsumoto H, Ueda T, Takemura M, Matsuoka H, Jinnai M, Otsuka K, Oguma T, Takeda T, Ito I, Chin K, Mishima M.
    • Journal Title

      J Investig Allergol Clin Immunol. 18(3)

      Pages: 202-6

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Impact of gastro-oesophageal reflux disease symptoms on COPD exacerbation.2008

    • Author(s)
      Terada K, Muro S, Sato S, Ohara T, Haruna A, Marumo S, Kinose D, Ogawa E, Hoshino Y, Niimi A, Terada T, Mishima M.
    • Journal Title

      Thorax 63(11)

      Pages: 951-5

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Longitudinal study of airway dimensions in chronic obstructive pulmonary disease using computed tomography.2008

    • Author(s)
      Ohara T, Hirai T, Sato S, Terada K, Kinose D, Haruna A, Marumo S, Nishioka M, Ogawa E, Nakano Y, Hoshino Y, Ito Y, Matsumoto H, Niimi A, Mio T, Chin K, Muro S, Mishima M.
    • Journal Title

      Respirology 13(3)

      Pages: 372-8

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Thioredoxin-1 ameliorates cigarette smoke-induced lung inflammation and emphysemain mice2008

    • Author(s)
      Sato A, Hoshino Y, Hara T, Muro S, Nakamura H, Mishima M, Yodoi J.
    • Journal Title

      J Pharmacol Exp Ther. 325(2)

      Pages: 380-8

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Plasma thioredoxin, a novel oxidative stress marker, in patients with obstructive sleep apnea before and after nasal continuous positive airway pressure.2008

    • Author(s)
      Takahashi K, Chin K, Nakamura H, Morita S, Sumi K, Oga T, Matsumoto H, Niimi A, Fukuhara S, Yodoi J, Mishima M.
    • Journal Title

      Antioxid Redox Signal. 10(4)

      Pages: 715-26

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Redox-based therapeutics for lung diseases.2008

    • Author(s)
      Hoshino Y, Mishima M.
    • Journal Title

      Antioxid Redox Signal. 10(4)

      Pages: 701-4

    • Related Report
      2008 Annual Research Report 2007 Annual Research Report
  • [Journal Article] TGFB1 promoter polymorphism C-509T and pathophysiology of asthma.2008

    • Author(s)
      Ueda T, Niimi A, Matsumoto H, Takemura M, Yamaguchi M, Matsuoka H, Jinnai M, Chin K, Minakuchi M, Cheng L, Shirakawa T, Mishima M.
    • Journal Title

      J Allergy Clin Immunol. 121(3)

      Pages: 659-64

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Longitudinal study of airway dimensions in chronic obstructive pulmonary disease using computed tomography.2008

    • Author(s)
      Ohara T, Hirai T, Sato S, Terada K, Kinose D, Haruna A, Marumo S, Nishioka M, Ogawa E, Nakano Y, Hoshino Y, Ito Y, Matsumoto H, Niimi A, Mio T, Chin K, Muro S, Mishima M.
    • Journal Title

      Respirology. 13(3)

      Pages: 372-8

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thioredoxin-1 ameliorates cigarette smoke-induced lung inflammation and emphysema in mice2008

    • Author(s)
      Sato A, Hoshino Y, Hara T, Muro S, Nakamura H, Mishima M, Yodoi J.
    • Journal Title

      J Pharmacol Exp Ther. 325(2)

      Pages: 380-8

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TGFB1 promoter polymorphism C-509T and pathophysiology of asthma.2008

    • Author(s)
      Ueda T, Niimi A, Matsumoto H, Takemura M, Yamaguchi M, Matsuoka H, Jinnai M, Chin K, Minakuchi M, Cheng L, Shirakawa T, Mishima
    • Journal Title

      J Allergy Clin Immunol. 121(3)

      Pages: 659-64

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Atopic features of cough variantasthma and classic asthma with wheezing2007

    • Author(s)
      Takemura M, Niimi A, Matsumoto H, Ueda T, Yamaguchi M, Matsuoka H, Jinnai M, Chin K, Mishima M.
    • Journal Title

      ClinExp Allergy 37(12)

      Pages: 1833-9

    • Related Report
      2008 Final Research Report
  • [Journal Article] Corticosteroid-induced myopathy mimickingtherapy-resistant asthma2007

    • Author(s)
      Yamaguchi M, Niimi A, Minakuchi M,Matsumoto H, Shimizu K, Chin K, Mishima M.
    • Journal Title

      Ann Allergy AsthmaImmunol 99(4)

      Pages: 371-4

    • Related Report
      2008 Final Research Report
  • [Journal Article] Analysis of longitudinalchanges in the psychological status of patientswith asthma2007

    • Author(s)
      Oga T, Nishimura K, Tsukino M, Sato S,Hajiro T, Mishima M
    • Journal Title

      Respir Med 101(10)

      Pages: 2133-8

    • Related Report
      2008 Final Research Report
  • [Journal Article] Neurotropin demonstrates cytoprotective effects in lung cells through the induction of thioredoxin-12007

    • Author(s)
      Hoshino Y, Nakamura T, Sato A, Mishima M,Yodoi J, Nakamura H
    • Journal Title

      Am J Respir Cell MolBiol 37(4)

      Pages: 438-46

    • Related Report
      2008 Final Research Report
  • [Journal Article] Airway wallthickening in patients with cough variant asthmaand nonasthmatic chronic cough2007

    • Author(s)
      Matsumoto H, Niimi A, Tabuena RP,Takemura M, Ueda T, Yamaguchi M, MatsuokaH, Jinnai M, Chin K, Mishima M.
    • Journal Title

      Chest 131(4)

      Pages: 1042-9

    • Related Report
      2008 Final Research Report
  • [Journal Article] Morphological mechanism of the development ofpulmonary emphysema in klotho mice2007

    • Author(s)
      Sato A, Hirai T, Imura A, Kita N, Iwano A,Muro S, Nabeshima Y, Suki B,Mishima M.
    • Journal Title

      Proc NatlAcad Sci USA 104(7)

      Pages: 2361-5

    • Related Report
      2008 Final Research Report
  • [Journal Article] Prevalence and clinical manifestations of gastro-oesophageal reflux-associated chronic cough in the Japanese population2007

    • Author(s)
      Matsumoto H, Niimi A, Takemura M, Ueda T,Yamaguchi M, Matsuoka H, Jinnai M, Chin K,Mishima M.
    • Journal Title

      Cough

      Pages: 3-1

    • NAID

      120004770220

    • Related Report
      2008 Final Research Report
  • [Journal Article] Longitudinal deteriorations in patient reported outcomes inpatients with COPD2007

    • Author(s)
      Oga T, Nishimura K, Tsukino M, Sato S,Hajiro T, Mishima M.
    • Journal Title

      Respir Med 101(1)

      Pages: 146-53

    • Related Report
      2008 Final Research Report
  • [Journal Article] Neurotropin demonstrates cytoprotective effects in lung cells through the induction of thioredoxin-1.2007

    • Author(s)
      Hoshino Y, Nakamura T, Sato A, Mishima M, Yodoi J, Nakamura H.
    • Journal Title

      Am J Respir Cell Mol Biol. 37(4)

      Pages: 438-46

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Atopic features of cough variant asthma and classic asthma with wheezing2007

    • Author(s)
      Takemura M, Niimi A, Matsumoto H, Ueda T, Yamaguchi M, Matsuoka H, Jinnai M, Chin K, Mishima M.
    • Journal Title

      Clin Exp Allergy. 37(12)

      Pages: 1833-9

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Elevation of serum thioredoxin in patients with gefitinib-induced interstitial lung disease.2007

    • Author(s)
      Sakuma K, Nakamura H, Nakamura T, Hoshino Y, Ueda S, Ichikawa M, Tabata C, Fujita S, Masago K, Yodoi J, Mishima M, Mio T.
    • Journal Title

      Intern Med. 46(23)

      Pages: 1905-9

    • NAID

      130000078603

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Corticosteroid-induced myopathy mimicking therapy-resistant asthma.2007

    • Author(s)
      Yamaguchi M, Niimi A, Minakuchi M, Matsumoto H, Shimizu K, Chin K, Mishima M.
    • Journal Title

      Ann Allergy Asthma Immunol. 99(4)

      Pages: 371-4

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of longitudinal changes in the psychological status of patients with asthma.2007

    • Author(s)
      Oga T, Nishimura K, Tsukino M, Sato S, Hajiro T, Mishima M.
    • Journal Title

      Respir Med. 101(10)

      Pages: 2133-8

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Morphological mechanism of the development of pulmonary emphysema in klotho mice.2007

    • Author(s)
      Sato A, Hirai T, Imura A, Kita N, Iwano A, Muro S, Nabeshima Y, Suki B, Mishima M
    • Journal Title

      Proc Natl Acad Sci U S A. Feb 13;104 (7)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Role of small airways in asthma : investigation using high-resolution computed tomography2006

    • Author(s)
      Ueda T, Niimi A, Matsumoto H, Takemura M, Hirai T, Yamaguchi M, Matsuoka H, Jinnai M, Muro S, Chin K, Mishima M.
    • Journal Title

      J Allergy Clin Immunol 118(5)

      Pages: 1019-25

    • Related Report
      2008 Final Research Report
  • [Journal Article] Thioredoxin-1 suppresses systemic inflammatory responses against cigarette smoking2006

    • Author(s)
      Sato A, Hara T, Nakamura H, Kato N, Hoshino Y, Kondo N, Mishima M, Yodoi J.
    • Journal Title

      Antioxid Redox Signal 8(9-10)

      Pages: 1891-6

    • Related Report
      2008 Final Research Report
  • [Journal Article] Comparison of airway dimensions in different anatomic locations on chest CT in patients with COPD2006

    • Author(s)
      Ohara T, Hirai T, Sato S, Sato A, Nishioka M, Muro S, Mishima M
    • Journal Title

      Respirology 11(5)

      Pages: 579-85

    • Related Report
      2008 Final Research Report
  • [Journal Article] High sensitivity C-reactive protein in asthma2006

    • Author(s)
      Takemura M, Matsumoto H, Niimi A, Ueda T, Matsuoka H, Yamaguchi M, Jinnai M, Muro S,Hirai T, Ito Y, Nakamura T, Mio T, Chin K, Mishima M.
    • Journal Title

      Eur Respir J 27(5)

      Pages: 908-12

    • Related Report
      2008 Final Research Report
  • [Journal Article] Prognosis of cough variant asthma : a retrospective analysis2006

    • Author(s)
      Matsumoto H, Niimi A, Takemura M, Ueda T, Tabuena R, Yamaguchi M, Matsuoka H, Hirai T, Muro S, Ito Y, Mio T, Chin K, Nishiyama H, Mishima M.
    • Journal Title

      J Asthma 43(2)

      Pages: 131-5

    • Related Report
      2008 Final Research Report
  • [Journal Article] Dyspnoea with activities of dailyliving versus peak dyspnoea during exercise in male patients with COPD2006

    • Author(s)
      Oga T, Nishimura K, Tsukino M, Hajiro T, Mishima M.
    • Journal Title

      Respir Med 100(6)

      Pages: 965-71

    • Related Report
      2008 Final Research Report
  • [Journal Article] Thioredoxin-l suppresses systemic inflammatory responses against cigarette smoking.2006

    • Author(s)
      Sato A, Hara T, Nakamura H, Kato N, Hoshino Y, Kondo N, Mishima M
    • Journal Title

      Antioxid Redox Signal 8 (9-10)

      Pages: 1891-1896

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Prognosis of cough variant asthma : a retrospective analysis.2006

    • Author(s)
      Motsumoto, H., A.Niimi, M.Takemura, T.Ueda, R.Tabuena, M.Yamaguchi, H.Matsuoka, T.Hirai, S.Muro, Y.Ito, T.Mio, K.Chin, H.Nishiyama, M.Mishima
    • Journal Title

      J Asthma 43 (2)

      Pages: 131-135

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Role of small airways in asthma : Investigation using high-resolution computed tomography.2006

    • Author(s)
      Ueda T, Niimi A, Matsumoto H, Takemura M, Hirai T, Yamaguchi M, Matsuoka H, Jinnai M, Muro S, Chin K, Mishima M
    • Journal Title

      J Allergy Clin Immunol 118

      Pages: 1019-1025

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Comparison of airway dimensions in different anatomic locations on chest CT in patients with COPD.2006

    • Author(s)
      Ohara T, Hirai T, Sato S, Sato A, Nishioka M, Muro S, Mishima M
    • Journal Title

      Respirology Sep;11 (5)

      Pages: 579-585

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Cough-ReflexSensitivity to Inhaled Capsaicin in ChronicObstructive Pulmonary Disease : the Impact onExacerbation Frequency

    • Author(s)
      Kunihiko Terada, M.D., Shigeo Muro, M.D.,Ph. D., Tadashi Ohara, M.D., Ph. D., AkaneHaruna, M.D., Satoshi Marumo, M.D., MegumiKudo, M.D., Emiko Ogawa, M.D., Ph. D.,Yuma Hoshino, M.D., Ph. D., Toyohiro Hirai,M.D., Ph. D., Akio Niimi, M.D., Ph. D.,Michiaki Mishima, M.D., Ph. D.
    • Journal Title

      Respirology (in press)

    • Related Report
      2008 Final Research Report
  • [Journal Article] Effect of inhaled corticosteroidson small airways in asthma: Investigation usingimpulse oscillometry

    • Author(s)
      Yamaguchi M, Niimi A, Ueda T, TakemuraM, Matsuoka H, Jinnai M, Otsuka K, Oguma T,Takeda T, Ito I, Matsumoto H, Hirai T, Chin K,Mishima M.
    • Journal Title

      Pulm Pharmacol Ther (in press)

    • Related Report
      2008 Final Research Report
  • [Journal Article] Impact of gastro-oesophageal reflux disease symptoms on chronic obstructive pulmonary disease exacerbation.

    • Author(s)
      Kunihiko Terada, Shigeo Muro, Susumu Sato, Tadashi Ohara, Akane Haruna, Satoshi Marumo, Daisuke Kinose, Emiko Ogawa, Yuma Hoshino, Akio Niimi, Michiaki Mishima.
    • Journal Title

      Thorax (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] M. Airway wall thickening in patients with cough variant asthma and nonasthmatic chronic cough.

    • Author(s)
      Matsumoto H, Niimi A, Tabuena RP, Takemura M, Ueda T, Yamaguchi M, Matsuoka H, Jinnai M, Chin K, Mishima
    • Journal Title

      Chest (in press)

    • Related Report
      2006 Annual Research Report
  • [Presentation] Regulation of Connective Tissue Growth Factor Gene Expression by Lipopolysaccharide in Bronchial Epithelial Cells2009

    • Author(s)
      M. Nishioka, E. Ogawa, T. Hirai, S. Muro, M. Mishima
    • Organizer
      2006 International Conference of American Thoracic Society
    • Place of Presentation
      San Diego Convention Center, San Diego, California, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] Sputum leukocytosis on stable condition predicts chronic obstructive pulmonary disease exacerbations2008

    • Author(s)
      Kunihiko Terada, Shigeo Muro, TadashiOhara, Akane Haruna, Satoshi Marumo, Daisuke Kinose, Emiko Ogawa, Yutaka Ito, Satoshi Ichiyama, Michiaki Mishima
    • Organizer
      2008 International Conferenceof American Thoracic Society
    • Place of Presentation
      Metro Toronto Convention Centre, Toronto, Canada
    • Related Report
      2008 Final Research Report
  • [Presentation] Relation between smallairways and patient reported outcomes in chronic obstructive pulmonary disease2008

    • Author(s)
      Akane Haruna, Toru Oga, Shigeo Muro, Tadashi Ohara, Kunihiko Terada, Daisuke Kinose, Satoshi Marumo, Yuma Hoshino, Toyohiro Hirai, Emiko Ogawa, Kazuo Chin, Michiaki Mishima
    • Organizer
      2008 International Conference of American ThoracicSociety
    • Place of Presentation
      Metro Toronto Convention Centre, Toronto, Canada
    • Related Report
      2008 Final Research Report
  • [Presentation] Chest Subcutaneous Fat Mass Measured by Chest Computed Tomography Correlated with Low Attenuation Areas in COPD2008

    • Author(s)
      E. Ogawa., T. Ohara, Kinose, Nishioka. Sakai, MD, S. Muro, T. Hirai, Y. Nakano, M. Mishima
    • Organizer
      2008 International Conference of American Thoracic Society
    • Place of Presentation
      MetroToronto Convention Centre, Toronto, Canada
    • Related Report
      2008 Final Research Report
  • [Presentation] Impaired swallowing reflex predisposes to COPD exacerbations2008

    • Author(s)
      Kunihiko Terada, Shigeo Muro, TadashiOhara, Megumi Kudo, Emiko Ogawa, YumaHoshino, Toyohiro Hirai, Akio Niimi, MichiakiMishima
    • Organizer
      18th Annual Conference of European Respiratory Society
    • Place of Presentation
      Messe Sud, Berlin, Germany
    • Related Report
      2008 Final Research Report
  • [Presentation] TNF-alpha Modulates Expressions of MMPs and Migratory Function of Human Airway Smooth Muscle Cells2008

    • Author(s)
      Ito I, Hamid Q, Niimi A, Matsumoto H,Yamaguchi M, Matsuoka H, Jinnai M, OtsukaK, Takeda T, Nakaji H, Mishima M
    • Organizer
      2008 International Conference of American Thoracic Society
    • Place of Presentation
      Metro Toronto Convention Centre, Toronto, Canada
    • Related Report
      2008 Final Research Report
  • [Presentation] Relationship between Small Airways Function, and Health Status, Dyspneaand Disease Control in Asthma2008

    • Author(s)
      Takeda T, Oga T, Niimi A, Matsumoto H, Ito I, Yamaguchi M, Matsuoka H, Jinnai M, Otsuka K, Oguma T, Nakaji H, Chin K, Mishima M
    • Organizer
      2008 International Conference of American Thoracic Society
    • Place of Presentation
      Metro Toronto Convention Centre, Toronto, Canada
    • Related Report
      2008 Final Research Report
  • [Presentation] Arterial Hypoxia Correlated with the Inflammatory Profile in Induced Sputum from COPD Patients2007

    • Author(s)
      Sato, S. Muro, S. Sato, M. Nishioka, Y. Hoshino, E. Ogawa, T. Hirai, H. Nakamura, J. Yodoi, M. Mishima
    • Organizer
      2007 International Conference of American Thoracic Society
    • Place of Presentation
      Moscone Convention Center, San Francisco, California, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] Corticosteroid Suppressed LPS Induced NOD2 Gene Expression in Airway Epithelial Cells/D2007

    • Author(s)
      Kinose, E. Ogawa, M. Nishioka, Y. Hoshino, T. Hirai, S. Muro, M. Mishima
    • Organizer
      2007 International Conference of American Thoracic Society
    • Place of Presentation
      Moscone Convention Center, San Francisco, California, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] Thioredoxin Suppressed Cigarette Smoke Induced Emphysema in Mice2007

    • Author(s)
      Sato, Y. Hoshino, M. Takenaka, S. Muro, H. Nakamura, J. Yodoi, M. Mishima
    • Organizer
      2007 International Conference of American Thoracic Society
    • Place of Presentation
      Moscone Convention Center, San Francisco, California, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] Respiratory Resistance In COPD Patients Using Impulse Oscillometry2007

    • Author(s)
      S. SATO, T. HIRAI, S. MURO AND M. MISHIMA
    • Organizer
      Biomedical Engineering Symposium
    • Place of Presentation
      Losangels, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] Morphological Mechanism Of The Development Of ulmonary Emphysema In Klotho Mice2007

    • Author(s)
      T. HIRAI, A. SATO, S. MURO, A. IMURA, Y. NABESHIMA AND M. MISHIMA
    • Organizer
      Biomedical Engineering Symposium
    • Place of Presentation
      Losangels, USA.
    • Related Report
      2008 Final Research Report
  • [Presentation] Impacts of gastro-oesophageal reflux symptoms on exacerbations of COPD2007

    • Author(s)
      K. Terada, S. Muro, A. Niimi, E. Ogawa, Y. Hoshino, S. Sato, T. Ohara, D. Kinose, A. Haruna, S. Marumo, M. Mishima
    • Organizer
      17th Annual Conference of European Respiratory Society
    • Place of Presentation
      Stockholm International Fair and Congress Center, Stockholm, Sweden
    • Related Report
      2008 Final Research Report
  • [Presentation] Geographic Difference in Chronic Cough Etiology : Comparison of Japan with the UK2007

    • Author(s)
      Niimi A, Ueda T, Matsumoto H, Chung KF, Mishima M
    • Organizer
      2007 International Conference of American Thoracic Society
    • Place of Presentation
      Moscone Convention Center, San Francisco, California, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] Dynamic Property of Central Airway Walls as Assessed by Computed Tomography (CT) : Correlation with Asthma Pathophysiology.2007

    • Author(s)
      Yamaguchi M, Niimi A, Matsumoto H,Ueda T, Takemura M, Matsuoka H, Jinnai M,Mishima M
    • Organizer
      2007 International Conference of American Thoracic Society
    • Place of Presentation
      Moscone Convention Center, San Francisco, California, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] Thioredoxin Prevents Cigarette Smoke Induced Oxidative Stress and Apoptosis2006

    • Author(s)
      A. Sato, Y. Hoshino, H. Nakamura, M.Narita, S. Muro, M. Mishima, J. Yodoi
    • Organizer
      2006 International Conference of American Thoracic Society
    • Place of Presentation
      San Diego Convention Center, San Diego, California, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] Annual Changes in Computed Tomography Measurements and Pulmonary Function in Patients with Chronic Obstructive Pulmonary Disease2006

    • Author(s)
      T. Ohara, T. Hirai, S. Sato, E. Ogawa, A. Sato,M. Nishioka, K. Terada, Kinose, S. Muro, M. Mishima
    • Organizer
      2006 International Conference of American Thoracic Society
    • Place of Presentation
      San Diego Convention Center, San Diego, California, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] Body Mass Index in Patients with Chronic Obstructive Pulmonary Disease ; Correlation with Low Attenuation Areas on Computed Tomography2006

    • Author(s)
      E. Ogawa, Y. Nakano, S. Muro, H. Sakai, T.Hirai, M. Mishima
    • Organizer
      2006 International Conference of American Thoracic Society
    • Place of Presentation
      San Diego Convention Center, San Diego, California, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] Comparison of airway dimensions in different anatomic locations on chest CT in patients with COPD2006

    • Author(s)
      Tadashi OHARA, Toyohiro HIRAI, Susumu SATO, Atsuyasu SATO, Michiyoshi NISHIOKA, Shigeo MURO, Michiaki MISHIMA
    • Organizer
      11th Congress of the Asian Pacific Society of Respirology
    • Place of Presentation
      Kyoto International Conference Hall, Kyoto, Japan
    • Related Report
      2008 Final Research Report
  • [Presentation] Longitudinal deteriorations in patient centered versus physiological measurements in patients with COPD2006

    • Author(s)
      T. Oga, K. Nishimura, M. Tsukino, S. Sato, T.Hajiro, M. Mishima
    • Organizer
      16th Annual Congress of European Respiratory Society
    • Place of Presentation
      International Congress Centre Munich, Munich, German
    • Related Report
      2008 Final Research Report
  • [Remarks] Harasawa Memorial Award(Asia Pacific Society of Respiratory Medicine)2008.11

    • Related Report
      2008 Final Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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