Comprehensive study on the phenotyping of COPD
Project/Area Number |
18209029
|
Research Category |
Grant-in-Aid for Scientific Research (A)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Respiratory organ internal medicine
|
Research Institution | Kyoto University |
Principal Investigator |
MISHIMA Michiaki Kyoto University, 大学院・医学研究科, 教授 (60190625)
|
Co-Investigator(Kenkyū-buntansha) |
NIIMI Akio 京都大学, 大学院・医学研究科, 准教授 (30252513)
HIRAI Toyohiro 京都大学, 大学院・医学研究科, 講師 (20359805)
MURO Shigeo 京都大学, 大学院・医学研究科, 講師 (60344454)
OGAWA Emiko 京都大学, 大学院・医学研究科, 助教 (00378671)
OGA Toru 京都大学, 大学院・医学研究科, 講師 (90378670)
HOSHINO Yuma 京都大学, 産学官連携研究員 (00378746)
中野 恭幸 滋賀医科大学, 医学部, 教授 (00362377)
|
Project Period (FY) |
2006 – 2008
|
Project Status |
Completed (Fiscal Year 2008)
|
Budget Amount *help |
¥50,050,000 (Direct Cost: ¥38,500,000、Indirect Cost: ¥11,550,000)
Fiscal Year 2008: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Fiscal Year 2007: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Fiscal Year 2006: ¥30,810,000 (Direct Cost: ¥23,700,000、Indirect Cost: ¥7,110,000)
|
Keywords | 画像診断 / 遺伝子多型 / 炎症 / 体重減少 / 胃食道逆流 / 骨そしょう症 / リモデリング / 慢性閉塞性肺疾患 / phenotyping / 動物モデル / 細胞培養 / 肺障害 |
Research Abstract |
マウスの肺気腫生成に対するチオレドキシンの予防効果を明らかにし、肺気腫自然発症のモデルであるklotho mouseの病理画像がフラクタル構造を呈することを明らかにした。さらに、COPDにおいて、GERD(胃食道逆流)の症状を持つ患者は、有意に急性増悪の頻度が高いこと、CT画像における気腫病変の程度は体重(BMI)や骨塩量(BMD)と有意な相関を認めることを明らかにした。
|
Report
(4 results)
Research Products
(77 results)
-
-
[Journal Article] Specific IgE response to trichophyton and asthma severity2009
Author(s)
Matsuoka H, Niimi A, Matsumoto H, Ueda T,Takemura M, Yamaguchi M, Jinnai M,, Otsuka K,Oguma T, Takeda T, Ito I, Chin K, Amitani R,Mishima M
-
Journal Title
Chest 135(4)
Pages: 898-903
Related Report
-
-
[Journal Article] Body mass index in male patients with COPD : correlation with low attenuation areas on CT.2009
Author(s)
Ogawa E, Nakano Y, Ohara T, Muro S, Hirai T,Sato S, Sakai H, Tsukino M, Kinose D, NishiokaM, Niimi A, Chin K, Par 辿 PD, Mishima M.
-
Journal Title
Related Report
-
-
[Journal Article] Specific IgE response to trichophyton and asthma severity.2009
Author(s)
Matsuoka H, Niimi A, Matsumoto H, Ueda T, Takemura M, Yamaguchi M, Jinnai M, Otsuka K, Oguma T, Takeda T, I to I, Chin K, Amitani R, Mishima M.
-
Journal Title
Chest. 135 (4)
Pages: 898-903
Related Report
-
-
[Journal Article] Body mass index in male patients with COPD : correlation with low attenuation areas on CT.2009
Author(s)
Ogawa E, Nakano Y, Ohara T, Muro S, Hirai T, Sato S, Sakai H, Tsukino M, Kinose D, Nishioka M, Niimi A, Chin K, Pare PD, Mishima M.
-
Journal Title
Related Report
-
[Journal Article] Relationship between pulmonary emphysema and osteoporosis assessed by CT in patients with COPD2008
Author(s)
Ohara T, Hirai T, Muro S, Haruna A, Terada K,Kinose D, Marumo S, Ogawa E, Hoshino Y,Niimi A, Chin K, Mishima M.
-
Journal Title
Chest 134(6)
Pages: 1244-9
Related Report
-
-
[Journal Article] Impact ofgastro-oesophageal reflux disease symptoms onCOPD exacerbation2008
Author(s)
Terada K, Muro S, Sato S, Ohara T, Haruna A,Marumo S, Kinose D, Ogawa E, Hoshino Y,Niimi A, Terada T, Mishima M
-
Journal Title
Thorax 63(11)
Pages: 951-5
Related Report
-
-
[Journal Article] Sputum levels of transforming growth factor-beta1 in asthma : relation to clinical and computed tomography findings2008
Author(s)
Yamaguchi M, Niimi A, Matsumoto H, UedaT, Takemura M, Matsuoka H, Jinnai M, OtsukaK, Oguma T, Takeda T, Ito I, Chin K, MishimaM
-
Journal Title
J Investig Allergol Clin Immunol 18(3)
Pages: 202-6
Related Report
-
[Journal Article] Longitudinal study of airway dimensions in chronic obstructive pulmonary disease using computed tomography2008
Author(s)
Ohara T, Hirai T, Sato S, Terada K, Kinose D, Haruna A, Marumo S, Nishioka M, Ogawa E,Nakano Y, Hoshino Y, Ito Y, Matsumoto H,Niimi A, Mio T, Chin K, Muro S, Mishima M.
-
Journal Title
Respirology 13(3)
Pages: 372-8
Related Report
-
-
[Journal Article] TGFB1 promoter polymorphism C-509T andpathophysiology of asthma2008
Author(s)
Ueda T, Niimi A, Matsumoto H, Takemura M, Yamaguchi M, Matsuoka H, Jinnai M, Chin K, Minakuchi M, Cheng L, Shirakawa T, Mishima M.
-
Journal Title
J Allergy ClinImmunol 121(3)
Pages: 659-64
Related Report
-
[Journal Article] Relationship between pulmonary empliysema and osteoporosis assessed by CT in patients with COPD.2008
Author(s)
Ohara T, Hirai T, Muro S, Haruna A, Terada K, Kinose D, Marumo S, Ogawa E, Hoshino Y, Niimi A, Chin K, Mishima M.
-
Journal Title
Chest 134(6)
Pages: 1244-9
Related Report
-
-
[Journal Article] Sputum levels of transforming growth factor-betal in asthma : relation to clinical and computed tomography findings.2008
Author(s)
Yamaguchi M, Niimi A, Matsumoto H, Ueda T, Takemura M, Matsuoka H, Jinnai M, Otsuka K, Oguma T, Takeda T, Ito I, Chin K, Mishima M.
-
Journal Title
J Investig Allergol Clin Immunol. 18(3)
Pages: 202-6
Related Report
-
[Journal Article] Impact of gastro-oesophageal reflux disease symptoms on COPD exacerbation.2008
Author(s)
Terada K, Muro S, Sato S, Ohara T, Haruna A, Marumo S, Kinose D, Ogawa E, Hoshino Y, Niimi A, Terada T, Mishima M.
-
Journal Title
Thorax 63(11)
Pages: 951-5
Related Report
-
[Journal Article] Longitudinal study of airway dimensions in chronic obstructive pulmonary disease using computed tomography.2008
Author(s)
Ohara T, Hirai T, Sato S, Terada K, Kinose D, Haruna A, Marumo S, Nishioka M, Ogawa E, Nakano Y, Hoshino Y, Ito Y, Matsumoto H, Niimi A, Mio T, Chin K, Muro S, Mishima M.
-
Journal Title
Respirology 13(3)
Pages: 372-8
Related Report
-
-
[Journal Article] Plasma thioredoxin, a novel oxidative stress marker, in patients with obstructive sleep apnea before and after nasal continuous positive airway pressure.2008
Author(s)
Takahashi K, Chin K, Nakamura H, Morita S, Sumi K, Oga T, Matsumoto H, Niimi A, Fukuhara S, Yodoi J, Mishima M.
-
Journal Title
Antioxid Redox Signal. 10(4)
Pages: 715-26
Related Report
-
-
[Journal Article] TGFB1 promoter polymorphism C-509T and pathophysiology of asthma.2008
Author(s)
Ueda T, Niimi A, Matsumoto H, Takemura M, Yamaguchi M, Matsuoka H, Jinnai M, Chin K, Minakuchi M, Cheng L, Shirakawa T, Mishima M.
-
Journal Title
J Allergy Clin Immunol. 121(3)
Pages: 659-64
Related Report
-
[Journal Article] Longitudinal study of airway dimensions in chronic obstructive pulmonary disease using computed tomography.2008
Author(s)
Ohara T, Hirai T, Sato S, Terada K, Kinose D, Haruna A, Marumo S, Nishioka M, Ogawa E, Nakano Y, Hoshino Y, Ito Y, Matsumoto H, Niimi A, Mio T, Chin K, Muro S, Mishima M.
-
Journal Title
Respirology. 13(3)
Pages: 372-8
Related Report
Peer Reviewed
-
-
[Journal Article] TGFB1 promoter polymorphism C-509T and pathophysiology of asthma.2008
Author(s)
Ueda T, Niimi A, Matsumoto H, Takemura M, Yamaguchi M, Matsuoka H, Jinnai M, Chin K, Minakuchi M, Cheng L, Shirakawa T, Mishima
-
Journal Title
J Allergy Clin Immunol. 121(3)
Pages: 659-64
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Elevation of serum thioredoxin in patients with gefitinib-induced interstitial lung disease.2007
Author(s)
Sakuma K, Nakamura H, Nakamura T, Hoshino Y, Ueda S, Ichikawa M, Tabata C, Fujita S, Masago K, Yodoi J, Mishima M, Mio T.
-
Journal Title
Intern Med. 46(23)
Pages: 1905-9
NAID
Related Report
Peer Reviewed
-
-
-
-
[Journal Article] Role of small airways in asthma : investigation using high-resolution computed tomography2006
Author(s)
Ueda T, Niimi A, Matsumoto H, Takemura M, Hirai T, Yamaguchi M, Matsuoka H, Jinnai M, Muro S, Chin K, Mishima M.
-
Journal Title
J Allergy Clin Immunol 118(5)
Pages: 1019-25
Related Report
-
-
-
[Journal Article] High sensitivity C-reactive protein in asthma2006
Author(s)
Takemura M, Matsumoto H, Niimi A, Ueda T, Matsuoka H, Yamaguchi M, Jinnai M, Muro S,Hirai T, Ito Y, Nakamura T, Mio T, Chin K, Mishima M.
-
Journal Title
Eur Respir J 27(5)
Pages: 908-12
Related Report
-
[Journal Article] Prognosis of cough variant asthma : a retrospective analysis2006
Author(s)
Matsumoto H, Niimi A, Takemura M, Ueda T, Tabuena R, Yamaguchi M, Matsuoka H, Hirai T, Muro S, Ito Y, Mio T, Chin K, Nishiyama H, Mishima M.
-
Journal Title
J Asthma 43(2)
Pages: 131-5
Related Report
-
-
-
[Journal Article] Prognosis of cough variant asthma : a retrospective analysis.2006
Author(s)
Motsumoto, H., A.Niimi, M.Takemura, T.Ueda, R.Tabuena, M.Yamaguchi, H.Matsuoka, T.Hirai, S.Muro, Y.Ito, T.Mio, K.Chin, H.Nishiyama, M.Mishima
-
Journal Title
J Asthma 43 (2)
Pages: 131-135
Related Report
-
[Journal Article] Role of small airways in asthma : Investigation using high-resolution computed tomography.2006
Author(s)
Ueda T, Niimi A, Matsumoto H, Takemura M, Hirai T, Yamaguchi M, Matsuoka H, Jinnai M, Muro S, Chin K, Mishima M
-
Journal Title
J Allergy Clin Immunol 118
Pages: 1019-1025
Related Report
-
-
[Journal Article] Cough-ReflexSensitivity to Inhaled Capsaicin in ChronicObstructive Pulmonary Disease : the Impact onExacerbation Frequency
Author(s)
Kunihiko Terada, M.D., Shigeo Muro, M.D.,Ph. D., Tadashi Ohara, M.D., Ph. D., AkaneHaruna, M.D., Satoshi Marumo, M.D., MegumiKudo, M.D., Emiko Ogawa, M.D., Ph. D.,Yuma Hoshino, M.D., Ph. D., Toyohiro Hirai,M.D., Ph. D., Akio Niimi, M.D., Ph. D.,Michiaki Mishima, M.D., Ph. D.
-
Journal Title
Related Report
-
[Journal Article] Effect of inhaled corticosteroidson small airways in asthma: Investigation usingimpulse oscillometry
Author(s)
Yamaguchi M, Niimi A, Ueda T, TakemuraM, Matsuoka H, Jinnai M, Otsuka K, Oguma T,Takeda T, Ito I, Matsumoto H, Hirai T, Chin K,Mishima M.
-
Journal Title
Pulm Pharmacol Ther (in press)
Related Report
-
[Journal Article] Impact of gastro-oesophageal reflux disease symptoms on chronic obstructive pulmonary disease exacerbation.
Author(s)
Kunihiko Terada, Shigeo Muro, Susumu Sato, Tadashi Ohara, Akane Haruna, Satoshi Marumo, Daisuke Kinose, Emiko Ogawa, Yuma Hoshino, Akio Niimi, Michiaki Mishima.
-
Journal Title
Related Report
Peer Reviewed
-
-
-
[Presentation] Sputum leukocytosis on stable condition predicts chronic obstructive pulmonary disease exacerbations2008
Author(s)
Kunihiko Terada, Shigeo Muro, TadashiOhara, Akane Haruna, Satoshi Marumo, Daisuke Kinose, Emiko Ogawa, Yutaka Ito, Satoshi Ichiyama, Michiaki Mishima
Organizer
2008 International Conferenceof American Thoracic Society
Place of Presentation
Metro Toronto Convention Centre, Toronto, Canada
Related Report
-
[Presentation] Relation between smallairways and patient reported outcomes in chronic obstructive pulmonary disease2008
Author(s)
Akane Haruna, Toru Oga, Shigeo Muro, Tadashi Ohara, Kunihiko Terada, Daisuke Kinose, Satoshi Marumo, Yuma Hoshino, Toyohiro Hirai, Emiko Ogawa, Kazuo Chin, Michiaki Mishima
Organizer
2008 International Conference of American ThoracicSociety
Place of Presentation
Metro Toronto Convention Centre, Toronto, Canada
Related Report
-
[Presentation] Chest Subcutaneous Fat Mass Measured by Chest Computed Tomography Correlated with Low Attenuation Areas in COPD2008
Author(s)
E. Ogawa., T. Ohara, Kinose, Nishioka. Sakai, MD, S. Muro, T. Hirai, Y. Nakano, M. Mishima
Organizer
2008 International Conference of American Thoracic Society
Place of Presentation
MetroToronto Convention Centre, Toronto, Canada
Related Report
-
[Presentation] Impaired swallowing reflex predisposes to COPD exacerbations2008
Author(s)
Kunihiko Terada, Shigeo Muro, TadashiOhara, Megumi Kudo, Emiko Ogawa, YumaHoshino, Toyohiro Hirai, Akio Niimi, MichiakiMishima
Organizer
18th Annual Conference of European Respiratory Society
Place of Presentation
Messe Sud, Berlin, Germany
Related Report
-
[Presentation] TNF-alpha Modulates Expressions of MMPs and Migratory Function of Human Airway Smooth Muscle Cells2008
Author(s)
Ito I, Hamid Q, Niimi A, Matsumoto H,Yamaguchi M, Matsuoka H, Jinnai M, OtsukaK, Takeda T, Nakaji H, Mishima M
Organizer
2008 International Conference of American Thoracic Society
Place of Presentation
Metro Toronto Convention Centre, Toronto, Canada
Related Report
-
[Presentation] Relationship between Small Airways Function, and Health Status, Dyspneaand Disease Control in Asthma2008
Author(s)
Takeda T, Oga T, Niimi A, Matsumoto H, Ito I, Yamaguchi M, Matsuoka H, Jinnai M, Otsuka K, Oguma T, Nakaji H, Chin K, Mishima M
Organizer
2008 International Conference of American Thoracic Society
Place of Presentation
Metro Toronto Convention Centre, Toronto, Canada
Related Report
-
[Presentation] Arterial Hypoxia Correlated with the Inflammatory Profile in Induced Sputum from COPD Patients2007
Author(s)
Sato, S. Muro, S. Sato, M. Nishioka, Y. Hoshino, E. Ogawa, T. Hirai, H. Nakamura, J. Yodoi, M. Mishima
Organizer
2007 International Conference of American Thoracic Society
Place of Presentation
Moscone Convention Center, San Francisco, California, USA
Related Report
-
-
-
-
-
[Presentation] Impacts of gastro-oesophageal reflux symptoms on exacerbations of COPD2007
Author(s)
K. Terada, S. Muro, A. Niimi, E. Ogawa, Y. Hoshino, S. Sato, T. Ohara, D. Kinose, A. Haruna, S. Marumo, M. Mishima
Organizer
17th Annual Conference of European Respiratory Society
Place of Presentation
Stockholm International Fair and Congress Center, Stockholm, Sweden
Related Report
-
-
[Presentation] Dynamic Property of Central Airway Walls as Assessed by Computed Tomography (CT) : Correlation with Asthma Pathophysiology.2007
Author(s)
Yamaguchi M, Niimi A, Matsumoto H,Ueda T, Takemura M, Matsuoka H, Jinnai M,Mishima M
Organizer
2007 International Conference of American Thoracic Society
Place of Presentation
Moscone Convention Center, San Francisco, California, USA
Related Report
-
-
[Presentation] Annual Changes in Computed Tomography Measurements and Pulmonary Function in Patients with Chronic Obstructive Pulmonary Disease2006
Author(s)
T. Ohara, T. Hirai, S. Sato, E. Ogawa, A. Sato,M. Nishioka, K. Terada, Kinose, S. Muro, M. Mishima
Organizer
2006 International Conference of American Thoracic Society
Place of Presentation
San Diego Convention Center, San Diego, California, USA
Related Report
-
-
-
-